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Aliases for GRIK3 Gene

Aliases for GRIK3 Gene

  • Glutamate Ionotropic Receptor Kainate Type Subunit 3 2 3 5
  • Excitatory Amino Acid Receptor 5 3 4
  • Glutamate Receptor 7 3 4
  • GluR-7 3 4
  • GLUR7 3 4
  • GluK3 3 4
  • EAA5 3 4
  • DJ1090M5.1 (Glutamate Receptor, Ionotropic, Kainate 3 (GLUR7)) 3
  • Glutamate Receptor, Ionotropic, Kainate 3 2
  • Glutamate Receptor Ionotropic, Kainate 3 3
  • GluR7a 3
  • GLR7 3

External Ids for GRIK3 Gene

Previous GeneCards Identifiers for GRIK3 Gene

  • GC01M037087
  • GC01M036321
  • GC01M036693
  • GC01M036694
  • GC01M036935
  • GC01M037261
  • GC01M035378

Summaries for GRIK3 Gene

Entrez Gene Summary for GRIK3 Gene

  • Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRIK3 Gene

GRIK3 (Glutamate Ionotropic Receptor Kainate Type Subunit 3) is a Protein Coding gene. Diseases associated with GRIK3 include Schizophrenia and Alcohol Dependence. Among its related pathways are Presynaptic function of Kainate receptors and Transmission across Chemical Synapses. GO annotations related to this gene include ionotropic glutamate receptor activity and glutamate receptor activity. An important paralog of this gene is GRIK2.

UniProtKB/Swiss-Prot for GRIK3 Gene

  • Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.

Tocris Summary for GRIK3 Gene

  • Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. They contribute to excitatory postsynaptic currents in many regions of the CNS.

Gene Wiki entry for GRIK3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIK3 Gene

Genomics for GRIK3 Gene

Regulatory Elements for GRIK3 Gene

Enhancers for GRIK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F037071 0.6 ENCODE 11.3 -37.7 -37655 1.1 ZNF362 RFX1 BHLHE40 RAD21 YY1 ZFP69B ZNF316 ZNF692 ATF3 GRIK3 GC01P037040 MIR4255
GH01F037036 0.2 ENCODE 5.1 -1.7 -1677 0.2 CTCF ZBTB11 ZBTB40 ZBTB7A ETS1 GABPA SCRT2 IKZF1 FOXP2 EZH2 GRIK3 GC01P037040
GH01F036703 1 FANTOM5 ENCODE 2.8 +330.6 330642 0.2 CBX3 TBL1XR1 ZNF2 RAD21 ZNF143 ZNF391 CREM KLF13 ZNF263 ZNF654 ENSG00000234481 GRIK3 OSCP1 LOC105378648
GH01F037318 0.3 FANTOM5 1.6 -284.2 -284216 0.3 ZFHX2 EGR2 EPHA10 GRIK3 GC01P037318 ENSG00000223944
GH01F037037 1.1 ENCODE 0.8 -3.3 -3327 0.6 ZNF362 MAZ ZIC2 ZNF121 GATA3 ZNF366 PATZ1 GLIS1 PRDM10 FOXP2 GC01P037040 GRIK3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GRIK3 on UCSC Golden Path with GeneCards custom track

Genomic Location for GRIK3 Gene

Chromosome:
1
Start:
36,795,527 bp from pter
End:
37,034,548 bp from pter
Size:
239,022 bases
Orientation:
Minus strand

Genomic View for GRIK3 Gene

Genes around GRIK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIK3 Gene

Proteins for GRIK3 Gene

  • Protein details for GRIK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13003-GRIK3_HUMAN
    Recommended name:
    Glutamate receptor ionotropic, kainate 3
    Protein Accession:
    Q13003
    Secondary Accessions:
    • A9Z1Z8
    • B1AMS6
    • Q13004
    • Q16136

    Protein attributes for GRIK3 Gene

    Size:
    919 amino acids
    Molecular mass:
    104037 Da
    Quaternary structure:
    • Homotetramer, and heterotetramer with either GRIK4 or GRIK5. Interacts with PRKCABP (By similarity). Interacts with NETO2 (By similarity).

    Alternative splice isoforms for GRIK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRIK3 Gene

Post-translational modifications for GRIK3 Gene

  • Glycosylation at Asn 70, Asn 76, Asn 278, Asn 381, Asn 415, Asn 426, Asn 433, and Asn 548
  • Modification sites at PhosphoSitePlus

Other Protein References for GRIK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRIK3 Gene

Domains & Families for GRIK3 Gene

Gene Families for GRIK3 Gene

Graphical View of Domain Structure for InterPro Entry

Q13003

UniProtKB/Swiss-Prot:

GRIK3_HUMAN :
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK3 subfamily.
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK3 subfamily.
genes like me logo Genes that share domains with GRIK3: view

Function for GRIK3 Gene

Molecular function for GRIK3 Gene

GENATLAS Biochemistry:
glutamate receptor 7,ionotropic,kainate (2-carboxy-4-(1-methenylethenyl)-3-pyrrolidinacetic) class
UniProtKB/Swiss-Prot Function:
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.

Gene Ontology (GO) - Molecular Function for GRIK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity IDA 9144652
GO:0001664 G-protein coupled receptor binding TAS --
GO:0004872 receptor activity IEA --
GO:0004970 ionotropic glutamate receptor activity ISS,IDA --
GO:0005216 ion channel activity IEA --
genes like me logo Genes that share ontologies with GRIK3: view
genes like me logo Genes that share phenotypes with GRIK3: view

Animal Models for GRIK3 Gene

MGI Knock Outs for GRIK3:

Animal Model Products

miRNA for GRIK3 Gene

miRTarBase miRNAs that target GRIK3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRIK3 Gene

Localization for GRIK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIK3 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRIK3 Gene COMPARTMENTS Subcellular localization image for GRIK3 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for GRIK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 7719709
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with GRIK3: view

Pathways & Interactions for GRIK3 Gene

genes like me logo Genes that share pathways with GRIK3: view

Gene Ontology (GO) - Biological Process for GRIK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway IEA --
GO:0007215 glutamate receptor signaling pathway IDA 7719709
GO:0007216 G-protein coupled glutamate receptor signaling pathway IDA 9144652
genes like me logo Genes that share ontologies with GRIK3: view

No data available for SIGNOR curated interactions for GRIK3 Gene

Drugs & Compounds for GRIK3 Gene

(26) Drugs for GRIK3 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Topiramate Approved Pharma GluR5 receptor antagonist,anticonvulsant, GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV 247
Domoic acid Experimental Pharma Full agonist, Agonist Potent, selective kainate agonist 0
kainate Pharma Full agonist, Agonist 0
L-Glutamic Acid Nutra Full agonist, Agonist, Target 0
ACET Pharma Antagonist Potent antagonist of GluR5-containing kainate receptors 0

(1) Additional Compounds for GRIK3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for GRIK3 Gene

Compound Action Cas Number
ACET Potent antagonist of GluR5-containing kainate receptors 936095-50-0
CNQX Potent AMPA/kainate antagonist 115066-14-3
Domoic acid Potent, selective kainate agonist 14277-97-5
Kainic acid Potent excitant and neurotoxin 487-79-6
Topiramate GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV 97240-79-4

(12) ApexBio Compounds for GRIK3 Gene

Compound Action Cas Number
(S)-(-)-5-Iodowillardiine 140187-25-3
ACET 936095-50-0
ATPA 140158-50-5
Domoic acid 14277-97-5
Kainic acid kainate receptor agonist, selective 487-79-6
NS 3763 70553-45-6
PDZ1 Domain inhibitor peptide 1315378-73-4
SYM 2081 31137-74-3
UBP 296 745055-86-1
UBP 301 569371-10-4
UBP 302 745055-91-8
UBP 310 902464-46-4
genes like me logo Genes that share compounds with GRIK3: view

Transcripts for GRIK3 Gene

mRNA/cDNA for GRIK3 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRIK3 Gene

Glutamate receptor, ionotropic, kainate 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIK3 Gene

No ASD Table

Relevant External Links for GRIK3 Gene

GeneLoc Exon Structure for
GRIK3
ECgene alternative splicing isoforms for
GRIK3

Expression for GRIK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GRIK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIK3 Gene

This gene is overexpressed in Nerve - Tibial (x6.0) and Brain - Cortex (x4.5).

Protein differential expression in normal tissues from HIPED for GRIK3 Gene

This gene is overexpressed in Plasma (34.7), Heart (15.8), and Fetal Brain (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRIK3 Gene



Protein tissue co-expression partners for GRIK3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GRIK3 Gene:

GRIK3

SOURCE GeneReport for Unigene cluster for GRIK3 Gene:

Hs.128848
genes like me logo Genes that share expression patterns with GRIK3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GRIK3 Gene

Orthologs for GRIK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRIK3 34 35
  • 99.06 (n)
dog
(Canis familiaris)
Mammalia GRIK3 35
  • 99 (a)
OneToOne
LOC608269 34
  • 93.54 (n)
oppossum
(Monodelphis domestica)
Mammalia GRIK3 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRIK3 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GRIK3 34 35
  • 93.22 (n)
rat
(Rattus norvegicus)
Mammalia Grik3 34
  • 90.46 (n)
mouse
(Mus musculus)
Mammalia Grik3 34 16 35
  • 90.17 (n)
chicken
(Gallus gallus)
Aves GRIK3 34 35
  • 83.13 (n)
lizard
(Anolis carolinensis)
Reptilia GRIK3 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498426 34
  • 75.66 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100334689 34
  • 75.37 (n)
GRIK3 35
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11155 36
  • 53 (a)
CG3822 36 35
  • 46 (a)
CG9935 36
  • 42 (a)
CG5621 36 35
  • 40 (a)
clumsy 36 35
  • 40 (a)
Kai-RIA 36
  • 37 (a)
KaiRIA 35
  • 33 (a)
ManyToMany
CG15627 36
  • 32 (a)
Glu-RIIA 36
  • 31 (a)
GluRIIE 35
  • 31 (a)
ManyToMany
CG4226 36
  • 30 (a)
Glu-RIIB 36
  • 29 (a)
GluRIIA 35
  • 29 (a)
ManyToMany
GluRIIC 35
  • 28 (a)
ManyToMany
GluRIIB 35
  • 27 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea glr-4 36
  • 35 (a)
Species where no ortholog for GRIK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRIK3 Gene

ENSEMBL:
Gene Tree for GRIK3 (if available)
TreeFam:
Gene Tree for GRIK3 (if available)

Paralogs for GRIK3 Gene

Paralogs for GRIK3 Gene

genes like me logo Genes that share paralogs with GRIK3: view

Variants for GRIK3 Gene

Sequence variations from dbSNP and Humsavar for GRIK3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs755366301 A colorectal cancer sample 36,872,276(+) AGGGG(C/T)GCGAG reference, missense
VAR_035696 A breast cancer sample
rs138941744 Uncertain significance 36,850,369(+) GGCCT(C/T)GGCCT reference, missense
rs10157587 -- 37,008,393(+) acagt(G/T)cctTC intron-variant
rs1027597 -- 36,927,817(-) ACACT(C/T)TCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRIK3 Gene

Variant ID Type Subtype PubMed ID
dgv19e201 CNV deletion 23290073
dgv231n54 CNV loss 21841781
dgv232n54 CNV gain 21841781
esv1102722 CNV insertion 17803354
esv23328 CNV loss 19812545
esv2459868 CNV deletion 19546169
esv2538711 CNV insertion 19546169
esv2553528 CNV loss 19546169
esv2747007 CNV deletion 23290073
esv2747030 CNV deletion 23290073
esv2747052 CNV deletion 23290073
esv2747074 CNV deletion 23290073
esv2747096 CNV deletion 23290073
esv2747107 CNV deletion 23290073
esv2747118 CNV deletion 23290073
esv2747129 CNV deletion 23290073
esv2747142 CNV deletion 23290073
esv2906 CNV loss 18987735
esv3151 CNV loss 18987735
esv3560793 CNV deletion 23714750
esv7566 CNV loss 19470904
nsv1003721 CNV gain 25217958
nsv1124223 CNV deletion 24896259
nsv1137749 CNV deletion 24896259
nsv1150669 CNV deletion 26484159
nsv466 CNV deletion 18451855
nsv473098 CNV novel sequence insertion 20440878
nsv522473 CNV loss 19592680
nsv546001 CNV loss 21841781
nsv546002 CNV loss 21841781
nsv546011 CNV loss 21841781
nsv546012 CNV loss 21841781
nsv546013 CNV loss 21841781
nsv821045 CNV duplication 20802225
nsv834713 CNV gain 17160897
nsv950621 CNV deletion 24416366

Variation tolerance for GRIK3 Gene

Residual Variation Intolerance Score: 2.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRIK3 Gene

Human Gene Mutation Database (HGMD)
GRIK3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRIK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIK3 Gene

Disorders for GRIK3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GRIK3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
alcohol dependence
  • alcohol dependence, protection against
- elite association - COSMIC cancer census association via MalaCards
Search GRIK3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GRIK3

Genetic Association Database (GAD)
GRIK3
Human Genome Epidemiology (HuGE) Navigator
GRIK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRIK3
genes like me logo Genes that share disorders with GRIK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRIK3 Gene

Publications for GRIK3 Gene

  1. Chromosomal localization of gene for human glutamate receptor subunit-7. (PMID: 8128318) Puranam R.S. … McNamara J.O. (Somat. Cell Mol. Genet. 1993) 2 3 4 22 64
  2. An association of GRIK3 Ser310Ala functional polymorphism with personality traits. (PMID: 19221446) Minelli A. … Gennarelli M. (Neuropsychobiology 2009) 3 22 46 64
  3. Association between the ionotropic glutamate receptor kainate3 (GRIK3) Ser310Ala polymorphism and schizophrenia in the Indian population. (PMID: 19921975) Ahmad Y. … Sinha S. (World J. Biol. Psychiatry 2009) 3 22 46 64
  4. Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder. (PMID: 16958029) Schiffer H.H. … Heinemann S.F. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 22 46 64
  5. Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholics. (PMID: 16314883) Preuss U.W. … Soyka M. (Pharmacogenomics J. 2006) 3 22 46 64

Products for GRIK3 Gene

Sources for GRIK3 Gene

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