Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GRIK3 Gene

Aliases for GRIK3 Gene

  • Glutamate Receptor, Ionotropic, Kainate 3 2 3
  • GLUR7 3 4 6
  • Excitatory Amino Acid Receptor 5 3 4
  • Glutamate Receptor 7 3 4
  • GluR-7 3 4
  • GluK3 3 4
  • EAA5 3 4
  • DJ1090M5.1 (Glutamate Receptor, Ionotropic, Kainate 3 (GLUR7)) 3
  • Glutamate Receptor Ionotropic, Kainate 3 3
  • GluR7a 3
  • GLR7 3

External Ids for GRIK3 Gene

Previous GeneCards Identifiers for GRIK3 Gene

  • GC01M037087
  • GC01M036321
  • GC01M036693
  • GC01M036694
  • GC01M036935
  • GC01M037261
  • GC01M035378

Summaries for GRIK3 Gene

Entrez Gene Summary for GRIK3 Gene

  • Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRIK3 Gene

GRIK3 (Glutamate Receptor, Ionotropic, Kainate 3) is a Protein Coding gene. Diseases associated with GRIK3 include schizophrenia. Among its related pathways are CREB Pathway and CREB Pathway. GO annotations related to this gene include extracellular-glutamate-gated ion channel activity and kainate selective glutamate receptor activity. An important paralog of this gene is GRID2.

UniProtKB/Swiss-Prot for GRIK3 Gene

  • Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA

Tocris Summary for GRIK3 Gene

  • Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. The receptors contribute to excitatory postsynaptic currents in many regions of the CNS and play a role in short- and long-term synaptic plasticity. Kainate receptors consist of GluR5-7 and KA1-2 subunits. Each subunit has an extracellular N-terminus, a cytoplasmic C-terminus, three membrane-spanning segments and a p-loop that dips into the membrane from the cytoplasmic face to form the pore.

Gene Wiki entry for GRIK3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIK3 Gene

Genomics for GRIK3 Gene

Regulatory Elements for GRIK3 Gene

Genomic Location for GRIK3 Gene

Start:
36,795,527 bp from pter
End:
37,034,243 bp from pter
Size:
238,717 bases
Orientation:
Minus strand

Genomic View for GRIK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRIK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIK3 Gene

Proteins for GRIK3 Gene

  • Protein details for GRIK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13003-GRIK3_HUMAN
    Recommended name:
    Glutamate receptor ionotropic, kainate 3
    Protein Accession:
    Q13003
    Secondary Accessions:
    • A9Z1Z8
    • B1AMS6
    • Q13004
    • Q16136

    Protein attributes for GRIK3 Gene

    Size:
    919 amino acids
    Molecular mass:
    104037 Da
    Quaternary structure:
    • Homotetramer, and heterotetramer with either GRIK4 or GRIK5. Interacts with PRKCABP (By similarity). Interacts with NETO2 (By similarity).

    Alternative splice isoforms for GRIK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRIK3 Gene

Proteomics data for GRIK3 Gene at MOPED

Post-translational modifications for GRIK3 Gene

  • Glycosylation at Asn70, Asn76, Asn278, Asn381, Asn415, Asn426, Asn433, and Asn548
  • Modification sites at PhosphoSitePlus

Other Protein References for GRIK3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GRIK3 Gene

Domains for GRIK3 Gene

Gene Families for GRIK3 Gene

HGNC:
  • GR :Glutamate receptors
  • GRI :Ligand-gated ion channels / Glutamate receptors, ionotropic
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

Q13003

UniProtKB/Swiss-Prot:

GRIK3_HUMAN :
  • Q13003
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK3 subfamily.
genes like me logo Genes that share domains with GRIK3: view

Function for GRIK3 Gene

Molecular function for GRIK3 Gene

GENATLAS Biochemistry: glutamate receptor 7,ionotropic,kainate (2-carboxy-4-(1-methenylethenyl)-3-pyrrolidinacetic) class
UniProtKB/Swiss-Prot Function: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA

Gene Ontology (GO) - Molecular Function for GRIK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity IDA 9144652
GO:0004970 ionotropic glutamate receptor activity ISS --
GO:0005234 extracellular-glutamate-gated ion channel activity IBA --
GO:0005515 protein binding --
GO:0008066 glutamate receptor activity TAS 8128318
genes like me logo Genes that share ontologies with GRIK3: view

Phenotypes for GRIK3 Gene

MGI mutant phenotypes for GRIK3:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with GRIK3: view

Animal Models for GRIK3 Gene

MGI Knock Outs for GRIK3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GRIK3 Gene

Localization for GRIK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIK3 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRIK3 Gene COMPARTMENTS Subcellular localization image for GRIK3 gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for GRIK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 7719709
GO:0016020 membrane --
GO:0030054 cell junction IEA --
GO:0030424 axon ISS --
genes like me logo Genes that share ontologies with GRIK3: view

Pathways for GRIK3 Gene

genes like me logo Genes that share pathways with GRIK3: view

Gene Ontology (GO) - Biological Process for GRIK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway IDA 9144652
GO:0007215 glutamate receptor signaling pathway IDA 7719709
GO:0007216 G-protein coupled glutamate receptor signaling pathway IDA 9144652
GO:0007268 synaptic transmission TAS --
GO:0034220 ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with GRIK3: view

Compounds for GRIK3 Gene

(5) Tocris Compounds for GRIK3 Gene

Compound Action Cas Number
ACET Potent antagonist of GluR5-containing kainate receptors [936095-50-0]
ATPA Selective, potent GluR5 agonist [140158-50-5]
CNQX Potent AMPA/kainate antagonist [115066-14-3]
Kainic acid Potent excitant and neurotoxin [487-79-6]
UBP 310 GLUK5 antagonist [902464-46-4]

(1) Drugbank Compounds for GRIK3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target

(6) IUPHAR Ligand for GRIK3 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]UBP310 None None 6.3
SYM2081 Inhibitor Inhibition 5.5
[3H](2S,4R)-4-methylglutamate None None
kainate Agonist Full agonist
dysiherbaine Agonist Full agonist
[3H]kainate None None

(5) Novoseek inferred chemical compound relationships for GRIK3 Gene

Compound -log(P) Hits PubMed IDs
kainate 85.2 22
glutamate 73.6 18
nmda 50.4 4
serine 21.5 3
alanine 17.1 2
genes like me logo Genes that share compounds with GRIK3: view

Transcripts for GRIK3 Gene

mRNA/cDNA for GRIK3 Gene

(17) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRIK3 Gene

Glutamate receptor, ionotropic, kainate 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRIK3 Gene

No ASD Table

Relevant External Links for GRIK3 Gene

GeneLoc Exon Structure for
GRIK3
ECgene alternative splicing isoforms for
GRIK3

Expression for GRIK3 Gene

mRNA expression in normal human tissues for GRIK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIK3 Gene

This gene is overexpressed in Nerve - Tibial (6.0) and Brain - Cortex (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GRIK3 Gene

SOURCE GeneReport for Unigene cluster for GRIK3 Gene Hs.128848

genes like me logo Genes that share expressions with GRIK3: view

No data available for mRNA Expression by UniProt/SwissProt for GRIK3 Gene

Orthologs for GRIK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRIK3 35
  • 99.06 (n)
  • 99.56 (a)
GRIK3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GRIK3 35
  • 93.22 (n)
  • 99.13 (a)
GRIK3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRIK3 36
  • 99 (a)
OneToOne
LOC608269 35
  • 93.54 (n)
  • 99.24 (a)
mouse
(Mus musculus)
Mammalia Grik3 35
  • 90.17 (n)
  • 99.02 (a)
Grik3 16
Grik3 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRIK3 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRIK3 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grik3 35
  • 90.46 (n)
  • 99.02 (a)
chicken
(Gallus gallus)
Aves GRIK3 35
  • 83.13 (n)
  • 92.06 (a)
GRIK3 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRIK3 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498426 35
  • 75.66 (n)
  • 85.53 (a)
zebrafish
(Danio rerio)
Actinopterygii GRIK3 36
  • 70 (a)
OneToOne
LOC100334689 35
  • 75.37 (n)
  • 80.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3822 36
  • 47 (a)
ManyToMany
CG5621 36
  • 34 (a)
ManyToMany
clumsy 36
  • 33 (a)
ManyToMany
GluRIIA 36
  • 29 (a)
ManyToMany
GluRIIB 36
  • 27 (a)
ManyToMany
GluRIIC 36
  • 28 (a)
ManyToMany
GluRIIE 36
  • 31 (a)
ManyToMany
KaiRIA 36
  • 33 (a)
ManyToMany
CG4226 37
  • 30 (a)
clumsy 37
  • 40 (a)
CG3822 37
  • 46 (a)
CG15627 37
  • 32 (a)
Glu-RIIA 37
  • 31 (a)
CG5621 37
  • 40 (a)
Glu-RIIB 37
  • 29 (a)
CG9935 37
  • 42 (a)
Kai-RIA 37
  • 37 (a)
CG11155 37
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea glr-4 37
  • 35 (a)
Species with no ortholog for GRIK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRIK3 Gene

ENSEMBL:
Gene Tree for GRIK3 (if available)
TreeFam:
Gene Tree for GRIK3 (if available)

Paralogs for GRIK3 Gene

Paralogs for GRIK3 Gene

Selected SIMAP similar genes for GRIK3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with GRIK3: view

Variants for GRIK3 Gene

Sequence variations from dbSNP and Humsavar for GRIK3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs13178 -- 36,796,985(-) CCATC(C/T)GAGCC utr-variant-3-prime
rs471187 -- 36,830,827(+) aaaaa(A/G)aaaaa intron-variant
rs471411 -- 36,957,327(-) GCTCA(C/T)GGGGC intron-variant
rs471417 -- 36,956,599(-) AGCCT(G/T)GCAAG intron-variant
rs471654 -- 36,840,921(-) TGGCA(C/G)AAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRIK3 Gene

Variant ID Type Subtype PubMed ID
nsv871688 CNV Loss 21882294
nsv871864 CNV Gain 21882294
nsv834713 CNV Gain 17160897
nsv522473 CNV Loss 19592680
esv2747007 CNV Deletion 23290073
esv2553528 CNV Loss 19546169
esv2538711 CNV Insertion 19546169
dgv29e201 CNV Deletion 23290073
esv2747030 CNV Deletion 23290073
esv1102722 CNV Insertion 17803354
esv2747052 CNV Deletion 23290073
esv3151 CNV Deletion 18987735
esv2747074 CNV Deletion 23290073
esv2459868 CNV Deletion 19546169
esv2747096 CNV Deletion 23290073
esv2747107 CNV Deletion 23290073
esv2906 CNV Deletion 18987735
esv23328 CNV Loss 19812545
nsv821045 CNV Duplication 20802225
esv2747118 CNV Deletion 23290073
esv7566 CNV Loss 19470904
nsv870498 CNV Loss 21882294
esv2747129 CNV Deletion 23290073
nsv466 CNV Loss 18451855
esv2747142 CNV Deletion 23290073

Relevant External Links for GRIK3 Gene

HapMap Linkage Disequilibrium report
GRIK3
Human Gene Mutation Database (HGMD)
GRIK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIK3 Gene

Disorders for GRIK3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for GRIK3 Gene including...

Search for GRIK3 Gene in MalaCards »

(2) University of Copenhagen DISEASES for GRIK3 Gene

(1) Novoseek inferred disease relationships for GRIK3 Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 48.1 10

Relevant External Links for GRIK3

Genetic Association Database (GAD)
GRIK3
Human Genome Epidemiology (HuGE) Navigator
GRIK3
genes like me logo Genes that share disorders with GRIK3: view

No data available for UniProtKB/Swiss-Prot for GRIK3 Gene

Publications for GRIK3 Gene

  1. Chromosomal localization of gene for human glutamate receptor subunit-7. (PMID: 8128318) Puranam R.S. … McNamara J.O. (Somat. Cell Mol. Genet. 1993) 2 3 4 23
  2. Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains. (PMID: 11124978) Schiffer H.H. … Heinemann S.F. (J. Neurosci. 2000) 3 4 23
  3. Molecular characterization of the human EAA5 (GluR7) receptor: a high-affinity kainate receptor with novel potential RNA editing sites. (PMID: 7719709) Nutt S.L. … Kamboj R.K. (Recept. Channels 1994) 3 4 23
  4. Association between the ionotropic glutamate receptor kainate 3 (GRIK3) ser310ala polymorphism and schizophrenia. (PMID: 11986986) Begni S. … Gennarelli M. (Mol. Psychiatry 2002) 3 23 48
  5. No association between the ionotropic glutamate receptor kainate 3 gene ser310ala polymorphism and schizophrenia. (PMID: 15897672) Lai I.C. … Wang Y.C. (Neuropsychobiology 2005) 3 23 48

Products for GRIK3 Gene

Sources for GRIK3 Gene

Back to Top

Content