Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GRIK3 Gene

protein-coding   GIFtS: 66
GCID: GC01M037261

Glutamate Receptor, Ionotropic, Kainate 3

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Glutamate Receptor, Ionotropic, Kainate 31 2     GluR7a2
GLUR72 3 5     DJ1090M5.1 (Glutamate Receptor, Ionotropic, Kainate 3 (GLUR7))2
Excitatory Amino Acid Receptor 52 3     gluR-72
Glutamate Receptor 72 3     Glutamate Receptor Ionotropic, Kainate 32
EAA52 3     GluR-73
GluK32 3     GluR73
GLR72     

External Ids:    HGNC: 45811   Entrez Gene: 28992   Ensembl: ENSG000001638737   OMIM: 1382435   UniProtKB: Q130033   

Export aliases for GRIK3 gene to outside databases

Previous GC identifers: GC01M037087 GC01M036321 GC01M036693 GC01M036694 GC01M036935 GC01M035378


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GRIK3 Gene:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are
activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of
glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not
certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and
GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its
association with the pathogenesis of delirium tremens in alcoholics. (provided by RefSeq, Jul 2008)

GeneCards Summary for GRIK3 Gene:
GRIK3 (glutamate receptor, ionotropic, kainate 3) is a protein-coding gene. Diseases associated with GRIK3 include schizophrenia, and obsessive-compulsive disorder. GO annotations related to this gene include extracellular-glutamate-gated ion channel activity and kainate selective glutamate receptor activity. An important paralog of this gene is GRIA3.

UniProtKB/Swiss-Prot: GRIK3_HUMAN, Q13003
Function: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and
plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter
at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of
receptors that are named according to their selective agonists. This receptor binds domoate > kainate >>
L-glutamate = quisqualate >> AMPA = NMDA

summary for GRIK3 Gene:
Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and
AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. The receptors
contribute to excitatory postsynaptic currents in many regions of the CNS and play a role in short- and
long-term synaptic plasticity. Kainate receptors consist of GluR5-7 and KA1-2 subunits. Each subunit has an
extracellular N-terminus, a cytoplasmic C-terminus, three membrane-spanning segments and a p-loop that dips
into the membrane from the cytoplasmic face to form the pore.

Gene Wiki entry for GRIK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the GRIK3 gene promoter:
         AhR   Pax-5   NRSF form 1   Nkx2-5   NRSF form 2   FOXL1   Arnt   GATA-2   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRIK3 promoter sequence
   Search Chromatin IP Primers for GRIK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRIK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

GRIK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRIK3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M037261:  view genomic region     (about GC identifiers)

Start:
37,261,128 bp from pter      End:
37,499,844 bp from pter
Size:
238,717 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GRIK3_HUMAN, Q13003 (See protein sequence)
Recommended Name: Glutamate receptor ionotropic, kainate 3 precursor  
Size: 919 amino acids; 104037 Da
Subunit: Homotetramer, and heterotetramer with either GRIK4 or GRIK5. Interacts with PRKCABP (By similarity).
Interacts with NETO2 (By similarity)
Rna editing: Modified_positions=352; Note=Partially edited
Secondary accessions: B1AMS6 Q13004 Q16136

Explore the universe of human proteins at neXtProt for GRIK3: NX_Q13003

Explore proteomics data for GRIK3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn70, Asn76, Asn278, Asn381, Asn415, Asn426, Asn433, Asn548
  • Modification sites at PhosphoSitePlus

  • See GRIK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000822.2  
    ENSEMBL proteins: 
     ENSP00000362183   ENSP00000362185  
    Reactome Protein details: Q13003

    GRIK3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GRIK3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GRIK3
    GenScript Custom Purified and Recombinant Proteins Services for GRIK3
    Novus Biologicals GRIK3 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GRIK3

    GRIK3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for GRIK3
    OriGene Custom Antibody Services for GRIK3
    Novus Biologicals GRIK3 Antibodies
    Abcam antibodies for GRIK3
    Cloud-Clone Corp. Antibodies for GRIK3
    ThermoFisher Antibodies for GRIK3
    LSBio Antibodies in human, mouse, rat for GRIK3

    GRIK3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GRIK3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GRIK3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GRIK3
    Cloud-Clone Corp. CLIAs for GRIK3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    GRI: Ligand-gated ion channels / Glutamate receptors, ionotropic
    GR: Glutamate receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GluK3
    Ionotropic glutamate receptors

    5 InterPro protein domains:
     IPR028082 Peripla_BP_I
     IPR019594 Glu_rcpt_Glu/Gly-bd
     IPR001320 Iontro_glu_rcpt
     IPR001828 ANF_lig-bd_rcpt
     IPR001508 NMDA_rcpt

    Graphical View of Domain Structure for InterPro Entry Q13003

    ProtoNet protein and cluster: Q13003

    3 Blocks protein domains:
    IPB001320 Ionotropic glutamate receptor
    IPB001508 NMDA receptor signature
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GRIK3_HUMAN, Q13003
    Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK3 subfamily


    GRIK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRIK3_HUMAN, Q13003
    Function: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and
    plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter
    at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of
    receptors that are named according to their selective agonists. This receptor binds domoate > kainate >>
    L-glutamate = quisqualate >> AMPA = NMDA

         Genatlas biochemistry entry for GRIK3:
    glutamate receptor 7,ionotropic,kainate (2-carboxy-4-(1-methenylethenyl)-3-pyrrolidinacetic) class

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001640adenylate cyclase inhibiting G-protein coupled glutamate receptor activity IDA9144652
    GO:0004970ionotropic glutamate receptor activity ISS--
    GO:0005215transporter activity ----
    GO:0005234extracellular-glutamate-gated ion channel activity IBA--
    GO:0005515protein binding ----
         
    GRIK3 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Grik3):
     nervous system 

    GRIK3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Grik3tm1Cmul for GRIK3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRIK3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GRIK3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRIK3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GRIK3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat GRIK3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GRIK3 (see all 107):
    hsa-miR-576-3p hsa-miR-376b hsa-miR-485-3p hsa-miR-128 hsa-miR-134 hsa-miR-3074-3p hsa-miR-219-5p hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidGRIK3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GRIK3
    Predesigned siRNA for gene silencing in human, mouse, rat GRIK3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GRIK3

    Clone
    Products:
         
    OriGene clones in human, mouse for GRIK3 (see all 9)
    OriGene ORF clones in mouse, rat for GRIK3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GRIK3 (NM_000831)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRIK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRIK3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GRIK3
    Browse ESI BIO Cell Lines and PureStem Progenitors for GRIK3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIK3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GRIK3_HUMAN, Q13003: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell
    membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA7719709
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0030054cell junction IEA--

    GRIK3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GRIK3 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1ADP signalling through P2Y purinoceptor 12
    Presynaptic function of Kainate receptors0.76
    Activation of Ca-permeable Kainate Receptor0.35
    Activation of Kainate Receptors upon glutamate binding0.68
    Ionotropic activity of Kainate Receptors0.00
    2Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    3CREB Pathway
    CREB Pathway0.68
    Intracellular Calcium Signaling0.50
    4Circadian entrainment
    Glutamatergic synapse0.39
    5Peptide ligand-binding receptors
    Neuroactive ligand-receptor interaction0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GRIK3
        CREB Pathway
    Intracellular Calcium Signaling

    2 Reactome Pathways for GRIK3
        Activation of Ca-permeable Kainate Receptor
    Presynaptic function of Kainate receptors


    2 Kegg Pathways  (Kegg details for GRIK3):
        Neuroactive ligand-receptor interaction
    Glutamatergic synapse


    GRIK3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including GRIK3: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GRIK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for GRIK3 (Q130033 ENSP000003621834) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SDCBPO005603, ENSP000002601304I2D: score=1 STRING: ENSP00000260130
    GRIK5Q164783, ENSP000002628954I2D: score=2 STRING: ENSP00000262895
    FLNAP213333, ENSP000003588664I2D: score=1 STRING: ENSP00000358866
    GRIP1Q9Y3R03, ENSP000003810984I2D: score=1 STRING: ENSP00000381098
    PICK1Q9NRD53, ENSP000003494654I2D: score=1 STRING: ENSP00000349465
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0007196adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway IDA9144652
    GO:0007215glutamate receptor signaling pathway IDA7719709
    GO:0007216G-protein coupled glutamate receptor signaling pathway IDA9144652
    GO:0007268synaptic transmission TAS--

    GRIK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GRIK3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Domoic acid Potent, selective kainate agonist [14277-97-5]
    Kainic acidPotent excitant and neurotoxin[487-79-6]
    CNQXPotent AMPA/kainate antagonist[115066-14-3]
    UBP 302 Selective, potent kainate antagonist; active enantiomer of UBP 296 (Cat. No. 2078) [745055-91-8]
    ACETPotent antagonist of GluR5-containing kainate receptors[936095-50-0]

    1 DrugBank Compound for GRIK3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--17139284 17016423 8622118 11058796 1371217

    6 IUPHAR Ligands for GRIK3 (GluK3)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]UBP310
    NoneNone6.320837679
    [3H](2S,4R)-4-methylglutamate
    NoneNone6.3--
    kainate
    AgonistFull agonist6.3--
    dysiherbaine
    AgonistFull agonist6.3--
    SYM2081
    AgonistFull agonist6.3--
    [3H]kainate
    NoneNone6.3--

    5 Novoseek inferred chemical compound relationships for GRIK3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kainate 85.2 28 11160421 (3), 1371217 (2), 16325263 (2), 7719709 (2) (see all 15)
    glutamate 73.6 25 8128318 (3), 9832144 (3), 11160421 (2), 11986986 (2) (see all 12)
    nmda 50.4 4 1371217 (1), 11334999 (1), 18462708 (1), 7518497 (1)
    serine 21.5 6 19221446 (1), 11986986 (1), 18464067 (1)
    alanine 17.1 3 19221446 (1), 11986986 (1)



    GRIK3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GRIK3 gene: 
    NM_000831.3  

    Unigene Cluster for GRIK3:

    Glutamate receptor, ionotropic, kainate 3
    Hs.128848  [show with all ESTs]
    Unigene Representative Sequence: NM_000831
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373091(uc001caz.2) ENST00000373093(uc001cba.1) ENST00000462621
    ENST00000479620

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GRIK3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GRIK3 (see all 107):
    hsa-miR-576-3p hsa-miR-376b hsa-miR-485-3p hsa-miR-128 hsa-miR-134 hsa-miR-3074-3p hsa-miR-219-5p hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidGRIK3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GRIK3
    Predesigned siRNA for gene silencing in human, mouse, rat GRIK3
    Clone
    Products:
         
    OriGene clones in human, mouse for GRIK3 (see all 9)
    OriGene ORF clones in mouse, rat for GRIK3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GRIK3 (NM_000831)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRIK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRIK3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GRIK3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GRIK3
      QuantiTect SYBR Green Assays in human, mouse, rat GRIK3
      QuantiFast Probe-based Assays in human, mouse, rat GRIK3

    Additional mRNA sequence: 

    AJ249210.1 AJ299451.1 U16127.1 

    5 DOTS entries:

    DT.212801  DT.92415721  DT.95363837  DT.121448683  DT.70104348 

    17 AceView cDNA sequences:

    NM_000831 AJ249210 BU838329 AJ299451 AI573286 BQ187470 BM723552 BX283721 
    BI115856 U16127 BM561047 BF509857 AI361853 BI544689 AW898512 BV189736 
    AA058857 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GRIK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GRIK3 Expression
    About this image


    GRIK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Cartilage-like cells
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Ovary (Reproductive System)
             Pre-Granulosa Cells Primordial Follicle
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
    GRIK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GRIK3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.128848
        Pathway & Disease-focused RT2 Profiler PCR Array including GRIK3: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for GRIK3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GRIK3
    QuantiTect SYBR Green Assays in human, mouse, rat GRIK3
    QuantiFast Probe-based Assays in human, mouse, rat GRIK3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for GRIK3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grik31 , 5 glutamate receptor, ionotropic, kainate 31, 5 90.17(n)1
    99.02(a)1
      4 (58.91 cM)5
    148071  NM_001081097.21  NP_001074566.11 
     1254907005 
    chicken
    (Gallus gallus)
    Aves GRIK31 glutamate receptor, ionotropic, kainate 3 83.13(n)
    92.06(a)
      419619  XM_417766.3  XP_417766.2 
    lizard
    (Anolis carolinensis)
    Reptilia GRIK36
    glutamate receptor, ionotropic, kainate 3
    91(a)
    1 ↔ 1
    GL343426.1(56763-138496)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004984261 glutamate receptor ionotropic, kainate 3-like 75.66(n)
    85.53(a)
      100498426  XM_002938617.2  XP_002938663.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003346891 glutamate receptor ionotropic, kainate 3-like 75.37(n)
    80.27(a)
      100334689  XM_002664770.3  XP_002664816.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG111553 kainate selective glutamate receptor 53(a)
    (best of 10)
        --


    ENSEMBL Gene Tree for GRIK3 (if available)
    TreeFam Gene Tree for GRIK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GRIK3 gene
    GRIA32  GRIK52  GRIK12  GRIA42  GRIA22  GRIK22  GRID12  GRIA12  
    GRIK42  GRID22  
    14 SIMAP similar genes for GRIK3 using alignment to 6 protein entries:     GRIK3_HUMAN (see all proteins):
    GLUR5    GRIK2    GRIK1    GRIK5    GRIK4    GRIN1
    GRIA2    GRIA1    GRIN2A    GRIA4    GRIA3    GRID2
    GRIN3A    GRID1

    GRIK3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GRIK3 (see all 5256)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356954
    A colorectal cancer sample4--see VAR_0356952 R H mis40--------
    VAR_0356964
    A breast cancer sample4--see VAR_0356962 D H mis40--------
    rs1421206661,2
    C--37260691(+) TGTCCC/TGCCCT 1 -- ds50010--------
    rs1479219231,2
    C--37260780(+) TCAGGC/GCAGAC 1 -- ds50010--------
    rs1401124741,2
    --37261048(+) CCTGGC/GGGAAG 1 -- ds50010--------
    rs29930761,2
    C,F,A,H--37261085(+) TTCTCG/ATTCTA 1 -- ds500128Minor allele frequency- A:0.35EA NA NS WA CSA 2512
    rs1477556091,2
    --37261164(+) TTAAAA/GCCATA 1 -- ut310--------
    rs1409334341,2
    --37261269(+) AGAATA/GATTGG 1 -- ut310--------
    rs1501812741,2
    --37261611(+) CCTACA/GGAACC 1 -- ut310--------
    rs21746711,2
    H--37261713(+) CCTGAG/AGCTGA 1 -- ut31 ese34Minor allele frequency- A:0.00NS EA 420

    HapMap Linkage Disequilibrium report for GRIK3 (37261128 - 37499844 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GRIK3 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747129CNV Deletion23290073
    dgv29e201CNV Deletion23290073
    esv2747107CNV Deletion23290073
    esv2747052CNV Deletion23290073
    esv2747118CNV Deletion23290073
    esv2459868CNV Deletion19546169
    esv2747007CNV Deletion23290073
    esv2747074CNV Deletion23290073
    esv3151CNV Deletion18987735
    esv2747142CNV Deletion23290073

    Human Gene Mutation Database (HGMD): GRIK3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GRIK3
    DNA2.0 Custom Variant and Variant Library Synthesis for GRIK3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 138243    OMIM disorders: --

    12 diseases for GRIK3:    
    About MalaCards
    schizophrenia    obsessive-compulsive disorder    alcohol dependence    major depressive disorder
    mood disorder    retinoblastoma    parkinson's disease    breast and colorectal cancer
    neuroblastoma    colorectal cancer    neuronitis    malaria

    2 diseases from the University of Copenhagen DISEASES database for GRIK3:
    Alcohol dependence     Schizophrenia

    GRIK3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for GRIK3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 48.1 16 16325263 (3), 11986986 (3), 19921975 (2), 15897672 (1) (see all 5)

    Genetic Association Database (GAD): GRIK3
    Human Genome Epidemiology (HuGE) Navigator: GRIK3 (18 documents)

    Export disorders for GRIK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GRIK3 gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with GRIK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal localization of gene for human glutamate receptor subunit-7. (PubMed id 8128318)1, 2, 3, 9 Puranam R.S.... McNamara J.O. (Somat. Cell Mol. Genet. 1993)
    2. Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia. (PubMed id 16325263)1, 4, 9 Shibata H....Fukumaki Y. (Psychiatry Res 2006)
    3. Molecular characterization of the human EAA5 (GluR7) receptor: a high-affinity kainate receptor with novel potential RNA editing sites. (PubMed id 7719709)1, 2, 9 Nutt S.L.... Kamboj R.K. (Recept. Channels 1994)
    4. Association between the ionotropic glutamate receptor kainate 3 (GRIK3) ser310ala polymorphism and schizophrenia. (PubMed id 11986986)1, 4, 9 Begni S....Gennarelli M. (Mol. Psychiatry 2002)
    5. Association between the ionotropic glutamate receptor kainate3 (GRIK3) Ser310Ala polymorphism and schizophrenia in the Indian population. (PubMed id 19921975)1, 4, 9 Ahmad Y....Sinha S. (World J. Biol. Psychiatry 2009)
    6. Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder. (PubMed id 16958029)1, 4, 9 Schiffer H.H. and Heinemann S.F. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    7. Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder. (PubMed id 15094479)1, 4, 9 Delorme R....Leboyer M. (Neuroreport 2004)
    8. Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains. (PubMed id 11124978)1, 2, 9 Schiffer H.H.... Heinemann S.F. (J. Neurosci. 2000)
    9. An association of GRIK3 Ser310Ala functional polymorphism with personality traits. (PubMed id 19221446)1, 4, 9 Minelli A....Gennarelli M. (Neuropsychobiology 2009)
    10. Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholics. (PubMed id 16314883)1, 4, 9 Preuss U.W....Soyka M. (Pharmacogenomics J. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2899 HGNC: 4581 AceView: GRIK3 Ensembl:ENSG00000163873 euGenes: HUgn2899
    ECgene: GRIK3 Kegg: 2899 H-InvDB: GRIK3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GRIK3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GRIK3 gene:
    Search GeneIP for patents involving GRIK3

    Licensable Technologies for GRIK3 gene:
     Salk Institute: Kainate Receptor Subunit GluR7 Polymorphisms for Diagnosing Predisposition and for Therapy of Mood Disorders
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for GRIK3 (GluR7/GRIK3)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GRIK3   OriGene RNAi products in human, mouse, rat for GRIK3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for GRIK3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GRIK3  
     OriGene qSTAR qPCR primer pairs in human, mouse for GRIK3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GRIK3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GRIK3   OriGene Custom Protein Services for GRIK3  

     
     
     Block miRNA regulation of human, mouse, rat GRIK3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GRIK3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRIK3 Predesigned siRNA for gene silencing in human, mouse, rat GRIK3
     QuantiFast Probe-based Assays in human, mouse, rat GRIK3 QuantiTect SYBR Green Assays in human, mouse, rat GRIK3
     PCR Arrays including human, mouse, rat GRIK3 Search Chromatin IP Primers for GRIK3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GRIK3  GeneGlobe Interaction Network for GRIK3
     Regulatory tfbs in GRIK3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for GRIK3 GenScript cDNA clones with any tag delivered in your preferred vector for GRIK3
     GenScript Custom Assay Services for GRIK3 GenScript Custom overexpressing Cell Line Services for GRIK3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for GRIK3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GRIK3 antibodies
     GRIK3 proteins
     Antibodies for GRIK3
     See all of Abcam's Antibodies, Kits and Proteins for GRIK3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for GRIK3
     Antibodies for GRIK3
     ELISAs for GRIK3
     CLIAs for GRIK3



     Browse ESI BIO Cell Lines and PureStem Progenitors for GRIK3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIK3
     SwitchGear 3'UTR luciferase reporter plasmids for GRIK3
     SwitchGear Promoter luciferase reporter plasmids for GRIK3
     ThermoFisher Antibodies for GRIK3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRIK3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRIK3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GRIK3
     LSBio Antibodies in human, mouse, rat for GRIK3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GRIK3 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4