Show Advanced Search
""
""

Advanced Search (alpha)

""
 
Search By
Section
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS
Search by expression pattern


GRIK2 Gene

protein-coding   GIFtS: 63

GC06P101892
glutamate receptor, ionotropic, kainate 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GLUR6)
"" "" "" "" "" "" "" "" "" "" "" "" "" "" "" ""Services    
 "" "" "" "" "" "" "" "" "" "" "" "" ""

Aliases &
Descriptions
for GRIK2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

  User Feedback
Aliases & Descriptions
glutamate receptor, ionotropic, kainate 21 2     MGC744272
GLUR62 3 5     glutamate receptor, ionotropic kainate 22
Excitatory amino acid receptor 42 3     gluR-62
Glutamate receptor 62 3     GLUK62
EAA42 3     GLR62
MRT62 5     GluR-63
bA487F5.12     GluR63

External Ids:    HGNC: 45801   Entrez Gene: 28982   Ensembl: ENSG000001644187   UniProtKB: Q130023   

Search outside databases for aliases for GRIK2 gene

Previous GC identifers: GC06P101715 GC06P101863 GC06P101953

Summaries
for GRIK2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  User Feedback		 Entrez Gene summary for GRIK2:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated
in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate
receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by
this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is
thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants
encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with
autosomal recessive mental retardation. (provided by RefSeq)

UniProtKB/Swiss-Prot: GRIK2_HUMAN, Q13002
Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the
central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading
to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor
then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May
be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface
expression of NETO2 (By similarity)

"" summary for GRIK2:
Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and
AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. The receptors
contribute to excitatory postsynaptic currents in many regions of the CNS and play a role in short- and
long-term synaptic plasticity. Kainate receptors consist of GluR5-7 and KA1-2 subunits. Each subunit has an
extracellular N-terminus, a cytoplasmic C-terminus, three membrane-spanning segments and a p-loop that dips
into the membrane from the cytoplasmic face to form the pore.

Gene Wiki entry for GRIK2

Genomic Views
for GRIK2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
About This Section

  User Feedback		 Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the GRIK2 gene upstream (promoter) region "":
AP-1   TBP   GR-alpha   p53   HSF2   c-Jun   c-Fos   GR-beta   NRSF form 2   TFIID   

Epigenetics:
"" SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for GRIK2:  ""
MePH09315-1A   

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q16.3-q21   Ensembl cytogenetic band:  6q16.3   HGNC cytogenetic band: 6q16.3-q21

GRIK2 Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P101892:  view genomic region     (about GC identifiers)

Start:
 101,846,664 bp from pter
End:
 102,517,958 bp from pter
Size:
 671,295 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  

Proteins
for GRIK2 gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

  User Feedback		 UniProtKB/Swiss-Prot: GRIK2_HUMAN, Q13002 (See protein sequence)
Recommended Name: Glutamate receptor, ionotropic kainate 2 precursor  
Size: 908 amino acids; 102583 Da
Subunit: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the
dimerization of dimers (Probable). Assembles into a kainate-gated homomeric channel that does not bind AMPA. GRIK2
associated to GRIK5 forms functional channels that can be gated by AMPA (By similarity). Interacts with DLG4.
Interacts with NETO2 (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane;
Multi-pass membrane protein
Rna editing: Modified_positions=567, 571, 621; Note=Partially edited. The presence of Gln at position 621 (non-edited)
determines channels with low calcium permeability, whereas Arg (edited) determines a higher calcium permeability
especially if the preceding sites are fully edited. This receptor is nearly completely edited in all gray matter
structures (90% of the receptors), whereas much less edited in the white matter (10% of the receptors)
Miscellaneous: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their
selective agonists. This receptor binds domoate > kainate > quisqualate > 6-cyano-7-nitroquinoxaline-2,3-dione >
L-glutamate = 6,7-dinitroquinoxaline-2,3-dione > dihydrokainate
Secondary accessions: A6NMY9 B5MCV0 Q8WWS1 Q96KS6 Q96KS7 Q96KS8
Alternative splicing: 5 isoforms:  Q13002-1   Q13002-2   Q13002-3   Q13002-4   Q13002-5   

Post-translational modifications:

  • Sumoylation mediates kainate receptor-mediated endocytosis and regulates synaptic transmission. Sumoylation is enhanced
    • by PIAS3 and desumoylated by SENP1 (By similarity)1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (3 alternative transcripts): 
    NP_001159719.1  NP_068775.1  NP_786944.1  


    ENSEMBL proteins: 
    ENSP00000397026 ENSP00000405596 ENSP00000358134 ENSP00000391988 ENSP00000407140 ENSP00000351128 
    ENSP00000358133 ENSP00000358130 ENSP00000313276 ENSP00000384374 ENSP00000358129 


    Human Recombinant Proteins 
    ""Millipore Purified and/or Recombinant GRIK2 Protein
    ""Browse Human Recombinant Proteins at Sigma-Aldrich
    "" Browse R&D Systems for human recombinant proteins
    ""Enzo Life Sciences proteins for GRIK2
    ""HuPro® and/or Recombinant Proteins from Abnova for GRIK2 ""
    ""Browse Origene full length recombinant human proteins expressed in human HEK293 cells
    ""Novus Biologicals Protein for GRIK2  ""
    ""Browse Sino Biological Recombinant Proteins  ""

    5/14 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 14 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624 membrane fraction IEA--
    GO:0005886 plasma membrane IEA--
    GO:0005887 integral to plasma membrane TAS7536611
    GO:0016020 membrane ----
    GO:0030054 cell junction IEA--
    About this table

    "" GRIK2 for ontologies           About GeneDecksing



    Antibodies for GRIK2: 
    ""Millipore Mono- and Polyclonal Antibodies for the study of GRIK2
    ""Sigma-Aldrich Antibodies for GRIK2
    "" Browse R&D Systems for Antibodies
    ""Monoclonal and Polyclonal Antibodies from Abnova (GRIK2)
    ""Browse Origene Antibodies ""
    ""Novus Biologicals Antibodies for GRIK2
    ""Browse antibodies at Epitomics

    Assays for GRIK2: 
    ""Browse Kits and Assays available from Millipore
    ""Browse ELISAs at Sigma-Aldrich
    "" Browse R&D Systems for biochemical assays
    ""Enzo Life Sciences assays for GRIK2

    Protein Domains/
    Families
    for GRIK2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

      User Feedback
    "" GRIK2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR019594 Glu_rcpt_Glu/Gly-bd
     IPR015683 Glutamate_receptor-rel
     IPR001320 Iontro_glu_rcpt
     IPR001828 ANF_lig_bd_rcpt
     IPR001508 NMDA_rcpt

    Graphical View of Domain Structure for InterPro Entry Q13002

    ProtoNet protein and cluster: Q13002

    3 Blocks protein families:
    IPB001320 Ionotropic glutamate receptor
    IPB001508 NMDA receptor signature
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GRIK2_HUMAN, Q13002
    Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10) family

    Gene Function
    for GRIK2 gene

    (According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (GRIK2)
    "" Origene 29mer shRNA kits in GFP-retroviral vector (see all 3): GRIK2
    Origene shRNA RFP (see all 3): GRIK2
    Origene basic RS shRNA (see all 3): GRIK2

    ""Applied Biosystems Silencer® siRNAs for GRIK2
    ""Sigma-Aldrich siRNA Panels and siRNA for GRIK2
    Sigma-Aldrich shRNA for GRIK2
    Explore Sigma-Aldrich super-pooled esiRNAs
    Clones:""Millipore Clones for the Expression of GRIK2
    ""Browse iPSC Reprogramming Factors at Sigma-Aldrich
    "" Origene GFP tagged cDNA clones in CMV expression vector (see all 3): GRIK2
    Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): GRIK2
    Origene untagged cDNA clones in CMV expression vector (see all 4): GRIK2
    ""Browse Sino Biological Human cDNA Clones  ""

    UniProtKB/Swiss-Prot: GRIK2_HUMAN, Q13002
    Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the
    central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading
    to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor
    then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May
    be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface
    expression of NETO2 (By similarity)

    Genatlas biochemistry entry for GRIK2:
    glutamate receptor 6,ionotropic,kainate (2-carboxy-4-(1-methylethenyl)-3-pyrrolidinacetic) class

    5/11 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 11 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872 receptor activity IEA--
    GO:0004970 ionotropic glutamate receptor activity ----
    GO:0005215 transporter activity ----
    GO:0005216 ion channel activity IEA--
    GO:0005234 extracellular-glutamate-gated ion channel activity IEA--
    About this table

    "" GRIK2 for ontologies           About GeneDecksing

    Animal Models: 3 MGI mutant phenotypes (inferred from 2 alleles"") (MGI details for Grik2):

    behavior/neurologicalgrowth/sizenervous system

    "" GRIK2 for phenotypes           About GeneDecksing

    Pathways & Interactions
    for GRIK2 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
    About This Section

      User Feedback
    "" GRIK2 for pathways           About GeneDecksing

    1 "" Millipore Pathway for GRIK2
      ""  Glutamic acid signaling

    3 "" Sigma-Aldrich "Your Favorite Gene" Pathways for  GRIK2  (Your Favorite Gene powered by Ingenuity)
      ""  Amyotrophic Lateral Sclerosis Signaling
    CREB Signaling in Neurons
    Glutamate Receptor Signaling

    2 "" GeneAssist Pathways for GRIK2
      ""  Intracellular Calcium Signaling
    CREB Pathway

    1 "" Kegg Pathway  (Kegg details for GRIK2):
      ""  hsa04080 Neuroactive ligand-receptor interaction

    "" SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRIK2

    5/7 Interacting proteins for GRIK2 (ENSP000003581333) via UniProtKB, MINT, and/or STRING (see all 7 ) ""
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG4ENSP000002938133STRING: ENSP00000293813
    GRIA1ENSP000002859003STRING: ENSP00000285900
    DLG3ENSP000001949003STRING: ENSP00000194900
    DLG1ENSP000003457313STRING: ENSP00000345731
    GRIK5ENSP000003012183STRING: ENSP00000301218
    About this table

    5/21 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 21 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001662 behavioral fear response IEA--
    GO:0006810 transport NAS7536611
    GO:0006811 ion transport IEA--
    GO:0006874 cellular calcium ion homeostasis IEA--
    GO:0006886 intracellular protein transport IEA--
    About this table

    "" GRIK2 for ontologies           About GeneDecksing


    Drugs & Compounds
    for GRIK2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

      User Feedback
    "" GRIK2 for compounds           About GeneDecksing

    "" Enzo Life Sciences drugs & compounds for GRIK2
    ""Sigma-Aldrich Small Molecules for GRIK2:
    Small Molecule - Antagonist Small Molecule - Agonist Small Molecule - Mixed Agonist/Antagonist

    "" Compounds for GRIK2 available from Tocris Bioscience
    CompoundAction CAS number
    Domoic acidPotent, selective kainate agonist[14277-97-5]
    Kainic acidPotent excitant and neurotoxin[487-79-6]
    CNQX disodium saltPotent AMPA/kainate antagonist. More water soluble form of Cat. No. 0190[115066-14-3]
    About this table


    10/59 ""Novoseek chemical compound relationships for GRIK2 gene (see all 59 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    kainic acid 100.00 122 17486098 (4), 16624817 (4), 15976221 (4), 15509753 (4) (see all 86)
    glutamate 82.93 84 8964793 (4), 16354929 (3), 8889151 (2), 8260617 (2) (see all 68)
    ns102 11.36 3 16256962 (2), 19328223 (1)
    nmda 8.16 16 7952290 (2), 16126302 (2), 9808460 (1), 9729352 (1) (see all 14)
    6,7,8,9-tetrahydro-5-nitro-1h-benz[g]indole-2,3-dione 3-oxime 7.46 2 19328223 (1), 16256962 (1)
    ly339434 6.91 2 9849663 (2)
    gyki52466 6.04 2 16256962 (2)
    2s,4r-4-methylglutamate 5.65 2 9849663 (1), 15721240 (1)
    arginine 4.82 9 7681676 (3), 10051761 (3), 9202292 (1), 7696618 (1) (see all 5)
    glutamine 4.81 9 7681676 (3), 10051761 (2), 9202292 (1), 7696618 (1) (see all 6)
    About this table


    Transcripts
    for GRIK2 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
    Expression Assays from Applied Biosystems)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (GRIK2)
    ""Applied Biosystems Silencer® siRNAs:  NM_001166247  NM_021956  NM_175768  
    "" Origene 29mer shRNA kits in GFP-retroviral vector (see all 3): GRIK2
    Origene shRNA RFP (see all 3): GRIK2
    Origene basic RS shRNA (see all 3): GRIK2

    ""Sigma-Aldrich siRNA Panels and siRNA for GRIK2
    Sigma-Aldrich shRNA for GRIK2
    Explore Sigma-Aldrich super-pooled esiRNAs

    microRNA:""10/21 SABiosciences microRNAs that regulate GRIK2 (see all 21 ): ""
    hsa-miR-217 hsa-miR-448 hsa-miR-181c hsa-miR-376b hsa-let-7d hsa-let-7c hsa-miR-218 hsa-let-7g hsa-let-7a hsa-miR-181b
    Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
    NM_001166247  NM_021956  NM_175768  


    Clones:"" Origene GFP tagged cDNA clones in CMV expression vector (see all 3): GRIK2
    Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): GRIK2
    Origene untagged cDNA clones in CMV expression vector (see all 4): GRIK2
    Primers:"" Origene genome-wide validated SYBR primer pairs: GRIK2
    ""SABiosciences RT2 qPCR Primer Assay for GRIK2: PPH01863A ""

    REFSEQ mRNAs for GRIK2 gene (3 alternative transcripts): 

    NM_001166247.1  NM_021956.4  NM_175768.3  

    Additional cDNA sequence: 

    AJ252246.1 AJ301608.1 AJ301609.1 AJ301610.1 AK023497.1 AK289542.1 AK291965.1 AK303721.1 
    BC037954.1 BC063814.1 S75105.1 U16126.1 

    7 DOTS entries:

    DT.405648  DT.405649  DT.100778474  DT.100019840  DT.101968610  DT.100778473  DT.40264116 

    24/58 AceView cDNA sequences (see all 58 ):

    BQ717946 S75105 AJ301608 F03774 BX393577 BC063814 BX375160 AI401567 
    BX364426 AJ301610 BM987616 AI568655 BQ717881 NM_175768 NM_021956 AJ252246 
    U16126 BX345292 BX488122 AI087397 AW949408 AK023497 BU690115 CA397112 

    "" highest scoring ESTs for GRIK2:

    U16126 AJ252246 AJ301610 AW949408 BM722353 BU150676 H15472 AA322199 AA334499 AI401567 

    Unigene Cluster for GRIK2:

    Glutamate receptor, ionotropic, kainate 2
    Hs.98262  [show with all ESTs]
    Unigene Representative Sequence: NM_001166247


    GeneLoc Exon Structure

    13 Ensembl transcripts including schematic representations:
    ENST00000421544  ENST00000413795  ENST00000369138  ENST00000455610  ENST00000436862  ENST00000487161  
    ENST00000487395  ENST00000358361  ENST00000369137  ENST00000369134  ENST00000318991  ENST00000403289  
    ENST00000369133  

    Expression
    for GRIK2 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
    About This Section

      User Feedback

    GRIK2 expression in normal and diseased human tissues

    "" Applied Biosystems TaqMan ® Gene Expression Assays for GRIK2

    1""  / 2""  / 3""

    9 probe-sets matching GRIK2 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    39573_at2, 3 U95-A 1 1.00 1.00 0.80 1.20 U16126 1.00 1.00 1.00 1
    39572_at2, 3 U95-A 1 0.62 1.00 0.97 0.95 AI401567 0.60 1.00 0.82 1
    213845_at2 U133-A 1 0.64 1.00 -- -- -- -- -- -- --
    215655_at2, 3 U133-A 1 0.55 1.00 -- -- AU156204 0.40 1.00 0.76 1
    1560142_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    1563754_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    213845_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
    215655_at2 U133Plus2 1 0.55 1.00 -- -- -- -- -- -- --
    1555375_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    About this table

    "" GRIK2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.98262

    Expression variation in blood from EXPOLDB for GRIK2

    UniProtKB/Swiss-Prot: GRIK2_HUMAN, Q13002
    Tissue specificity: Expression is higher in cerebellum than in cerebral cortex

    Primers:"" Origene genome-wide validated SYBR primer pairs: GRIK2 ""
    ""SABiosciences RT2 qPCR Primer Assay for GRIK2: PPH01863A ""

    Orthologs
    for GRIK2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

      User Feedback
    Orthologs for GRIK2 gene from 5/13 species (see all 13 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 GRIK51   -- glutamate receptor, ionotropic, kainate 5 95.09(n)
    99.88(a)    		 481938  XM_539059.2  XP_539059.2 
    chimpanzee
    (Pan troglodytes)    		 GRIK51   -- glutamate receptor, ionotropic, kainate 5 99.78(n)
    100(a)    		 462899  XM_518653.2  XP_518653.2 
    cow
    (Bos taurus)    		 GRIK21   -- similar to glutamate receptor, ionotropic, kainate more 95.52(n)
    99.56(a)    		 615226  XM_866973.2  XP_872066.2 
    rat
    (Rattus norvegicus)    		 Grik21   -- glutamate receptor, ionotropic, kainate 2 92.07(n)
    98.79(a)    		 54257  NM_019309.1  NP_062182.1 
    mouse
    (Mus musculus)    		 Grik21, 5 10 (27.00 cM)5
    		 glutamate receptor, ionotropic, kainate 2 (beta 2)1, 5 91.78(n)1
    98.36(a)1    		 148061  NM_010349.11  NP_034479.11 
     AC1133055  AK1415395  (see all 19)
    About this table        Species with no ortholog for GRIK2

    ENSEMBL Gene Tree for GRIK2

    Paralogs
    for GRIK2 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      User Feedback
    Paralogs for GRIK2 gene
    GRIN3A2  GRIN2A2  GRIN2B2  GRIN2D2  GRIA32  GRIK52  GRIK12  GRIN3B2  
    GRIA42  GRIN2C2  GRIA22  GRIN12  GRID12  GRIA12  GRIK42  GRIK32  
    GRID22  

    "" GRIK2 for paralogs           About GeneDecksing


    Genomic Variants
    for GRIK2 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
    About This Section

      User Feedback
    10/4224 NCBI SNPs in GRIK2 are shown (see all 4224 )
    (Click "" for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 1415)
    ABGenomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    ""
    rs22350761,2
    		C,F,A99960457(+) AGGATG/ATCCCT 3 /I /M ref1 syn1 ut31 ese3""10Minor allele frequency- A:0.03NS EA NA 990""
    ""
    rs14159461,2
    		C,F,A99288712(+) CCTGGT/CCAAAA 2 -- ng51""7Minor allele frequency- C:0.23NS EA NA WA 536""
    ""
    rs28525131,2
    		C,F,A99288985(+) CAGATC/GGGTTG 2 -- ng51""2Minor allele frequency- G:0.16NA WA 122""
    ""
    rs28525121,2
    		C,F,A99288923(+) TAAAAG/ACAATG 2 -- ng51""6Minor allele frequency- A:0.21NS EA NA WA 540""
    ""
    rs38110801,2
    		F,H99287283(+) CTAGTT/GTCAAG 2 -- ng51""4Minor allele frequency- G:0.02NS EA 416""
    ""
    rs32136081,2
    		C,F99927557(+) ATGGCG/ATTGGC 4 /I /V mis1 ref1""8Minor allele frequency- A:0.00NS EA 832""
    --
    rs283834841,2
    		C,F99962180(+) TCTTGT/CATGTG 2 -- ng31""1Minor allele frequency- C:0.08NA 72""
    --
    rs119628431,2
    		C,H99288250(+) TATTTC/TTGTAC 2 -- ng51""0--------
    --
    rs28525111,2
    		C,F99288281(+) CTAACG/AAAAGC 2 -- ng51""7Minor allele frequency- A:0.15NS EA NA WA 540""
    --
    rs58786601,2
    		C99287931(+) GGAGG-/AAAAAA 2 -- ng51 trp3""0--------
    About this table

    HapMap Linkage Disequilibrium images for GRIK2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
    Database of Genomic Variants (DGV): 13 variations for GRIK2
         11 CNVs: 23778 32829 93918 64611 81514 64610 36442 7511 1135 1136 62553
         2 Indels: 64612 99641

    Disorders & Mutations
    for GRIK2 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      User Feedback
    "" GRIK2 for disorders           About GeneDecksing

    OMIM: 138244   disorders: 611092  

    UniProtKB/Swiss-Prot: GRIK2_HUMAN, Q13002

  • Defects in GRIK2 are the cause of mental retardation autosomal recessive type 6 (MRT6) [MIM:611092]. It is
    • characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative
    behavior and manifested during the developmental period. In contrast to syndromic or specific mental retardation which
    also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the
    only primary symptom of non-syndromic mental retardation. MRT6 patients display mild to severe mental retardation and
    psychomotor development delay in early childhood. Patients do not have neurologic problems, congenital malformations,
    or facial dysmorphism. Body height, weight, and head circumference are normal

    10/21 ""Novoseek disease relationships for GRIK2 gene (see all 21 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    brain; ischemic 10.02 8 16126302 (4), 19610093 (1), 19328223 (1), 16267825 (1) (see all 5)
    cerebral ischemia 10.01 11 17030433 (3), 16267825 (3), 16330502 (2), 16256962 (2) (see all 5)
    huntington disease 7.66 9 12821179 (3), 10522893 (3), 16959037 (2), 17018562 (1)
    idiopathic generalized epilepsy 4.41 3 7675232 (3)
    ischemia 4.18 14 18676085 (5), 18680160 (3), 8964793 (2), 19328223 (1) (see all 7)
    epilepticus; status 3.45 4 15857425 (4)
    mania 3.35 4 18332879 (3), 19596362 (1)
    transient cerebral ischemia 3.33 4 8964793 (2), 19477222 (1), 15308300 (1)
    hippocampal sclerosis 2.72 2 9848088 (2)
    epilepsy temporal lobe 2.20 3 9848088 (1), 11442354 (1), 10051761 (1)
    About this table

    Human Gene Mutation Database: GRIK2
    Genetic Association Database: GRIK2
    Human Genome Epidemiology Navigator: GRIK2 (15 documents)

    Medical News
    for GRIK2 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      User Feedback    		   --

    Publications
    for GRIK2 gene

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

      User Feedback    		10/129 PubMed articles for GRIK2 gene (see all 129 ):

    Search for GRIK2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

      User Feedback
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GRIK2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

      User Feedback
    Entrez Gene: 2898 HGNC: 4580 AceView: GRIK2 Ensembl:ENSG00000164418 euGenes: HUgn2898
    ECgene: GRIK2 Kegg: 2898 H-InvDB: GRIK2

    Other Databases showing GRIK2 gene

    (According to HUGE)
    About This Section

      User Feedback    		   --

    Specialized Databases showing GRIK2 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      User Feedback    		   --

    Intellectual Property
    for GRIK2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section

      User Feedback    		Patent Information for GRIK2 gene: ""
    Search GeneIP for patents involving GRIK2

    GeneCards and IP: ""
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search


    Services
    for GRIK2 gene

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
    Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
    Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section

      User Feedback    		""
    ""
    Products for GRIK2:
    "" TaqMan ® Gene Expression Assays
    "" TaqMan ® Genotyping Assays
    		 "" Free SNP selection tool

    ""
    "" Millipore Custom Antibody & Bulk Services
    "" Millipore Preclinical / Clinical Development Services
    "" Millipore Immunoassay Services
    "" Millipore Target Screening & Profiling Services

    ""
    "" Predesigned and custom siRNAs for GRIK2"" Antibodies for GRIK2
    "" Explore super-pooled esiRNAs"" Browse proteins at Sigma-Aldrich
    "" Lentivirus-delivered shRNAs for GRIK2"" Small molecules for GRIK2
    "" "Your Favorite Gene" Pathways"" Browse ELISAs at Sigma-Aldrich
    "" Browse iPSC Reprogramming Factors at Sigma-Aldrichfeedback


     ""  ""
    "" Antibodies  "" Primer Pairs  
    "" Cell Culture Products  "" ELISAs  
    "" Flow Cytometry Kits  "" Protease Activity Assays & Reagents  
    "" Cell Selection/Detection Kits & Reagents  "" ELISA/Assay Development Kits & Reagents  
    "" Multiplex/Array Assay Kits & Reagents  "" ELISpot Kits & Development Modules  
    "" Recombinant & Natural Proteins  

    "" Recombinant Proteins (GRIK2)
    "" Antibodies (GRIK2)
    "" Chimera RNAi (GRIK2)
    "" Custom Service for Mouse Mab
    "" Custom Service for Rabbit Pab from Full-length Protein


    """"""""
    "" Search for Antibodies & Assays

    "" Tagged/untagged cDNA clones
    "" Validated SYBR primer pairs
    "" Purified proteins from HEK293T cells
    "" Western blot validated antibodies
    "" shRNA in GFP-retroviral vector
    "" Custom immunoassay development
    "" Tocris compounds for GRIK2
    "" Regulatory tfbs in GRIK2 upstream (promoter) region
    "" Search Chromatin IP Primers for GRIK2
    "" DNA Methylation qPCR Primer Assays for GRIK2
    "" RT2 qPCR Primer Assay for GRIK2
    "" GNC Network for GRIK2
    "" microRNAs that regulate GRIK2
    """"""""
    "" Assays/Drugs/Proteins for GRIK2
    "" Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
    "" Novus Tissue Slides
    "" Antibodies for GRIK2
    "" Proteins for GRIK2
    "" Browse antibodies at Epitomics
    "" Browse Sino Biological Proteins and Antibodies
    "" Browse Sino Biological cDNA Clones
    "" Antibodies/Proteins Production Services
    "" Rabbit Monoclonal Antibody Platform
    "" Bulk Purchasing
      User Feedback        

    GeneCards Homepage - Last full update: 21 May 2010 - Incremental updates: 24 May 2010 , 20 Jun 2010

    View Random Gene

    Category
    acyl-CoA synthetase family member 3
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2010 , Weizmann Institute of Science. All Rights Reserved.
    GRIK2 gene at Home site.
    hostname: server4.xennexinc.com db build: 72 index build: 72d solr: 1.4