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Aliases for GRIK1-AS2 Gene

Subcategory (RNA class) for GRIK1-AS2 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for GRIK1-AS2 Gene

  • GRIK1 Antisense RNA 2 2 3
  • GRIK1 Antisense RNA 2 (Non-Protein Coding) 2 3
  • BACH1 4 5
  • Chromosome 21 Open Reading Frame 41 2
  • BTB Domain And CNC Homolog 1 5
  • Non-Protein Coding RNA 258 2
  • BTB And CNC Homolog 1 4
  • NCRNA00258 3
  • C21orf41 3
  • HA2303 4

External Ids for GRIK1-AS2 Gene

Previous HGNC Symbols for GRIK1-AS2 Gene

  • C21orf41
  • NCRNA00258

Previous GeneCards Identifiers for GRIK1-AS2 Gene

  • GC21P030970

Summaries for GRIK1-AS2 Gene

GeneCards Summary for GRIK1-AS2 Gene

GRIK1-AS2 (GRIK1 Antisense RNA 2) is an RNA Gene, and is affiliated with the non-coding RNA class. Among its related pathways are Integrated Breast Cancer Pathway and Integrated Cancer Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and heme binding. An important paralog of this gene is BACH2.

UniProtKB/Swiss-Prot for GRIK1-AS2 Gene

  • Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIK1-AS2 Gene

Genomics for GRIK1-AS2 Gene

Regulatory Elements for GRIK1-AS2 Gene

Enhancers for GRIK1-AS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21G029639 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +446.1 446139 1.6 ZNF766 ELK1 SMARCA5 CEBPB HDAC8 MEF2D HMBOX1 KDM1A ZNF24 IRF1 BACH1 GRIK1-AS2 ENSG00000273464 LOC105372768
GH21G029647 1.6 FANTOM5 ENCODE dbSUPER 11.3 +453.5 453451 0.3 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 FOS CAVIN1 JUNB BACH1 GRIK1-AS2 USP16 ENSG00000273464 LOC105372768
GH21G029648 1.3 ENCODE dbSUPER 11.3 +455.2 455189 2.4 PKNOX1 ATF1 ARNT TCF12 ZNF766 ELK1 GATA2 CAVIN1 NCOA1 ZNF592 BACH1 GRIK1-AS2 ENSG00000273464 LOC105372768
GH21G029641 1.3 ENCODE dbSUPER 11.3 +448.2 448178 1.3 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 ELK1 GATA2 FOS CAVIN1 BACH1 GRIK1-AS2 ENSG00000273464 LOC105372768
GH21G029634 0.7 dbSUPER 10.5 +441.0 440975 1.1 ZNF639 PKNOX1 L3MBTL2 HINFP E2F5 DDX20 ZNF175 ZNF592 PBX2 ZKSCAN8 BACH1 GRIK1-AS2 USP16 ENSG00000273464 LOC105372768
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GRIK1-AS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GRIK1-AS2 Gene

Chromosome:
21
Start:
29,194,071 bp from pter
End:
29,630,751 bp from pter
Size:
436,681 bases
Orientation:
Plus strand

Genomic View for GRIK1-AS2 Gene

Genes around GRIK1-AS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIK1-AS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIK1-AS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIK1-AS2 Gene

Proteins for GRIK1-AS2 Gene

  • Protein details for GRIK1-AS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14867-BACH1_HUMAN
    Recommended name:
    Transcription regulator protein BACH1
    Protein Accession:
    O14867
    Secondary Accessions:
    • O43285
    • Q6ICU0

    Protein attributes for GRIK1-AS2 Gene

    Size:
    736 amino acids
    Molecular mass:
    81958 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GRIK1-AS2 Gene

neXtProt entry for GRIK1-AS2 Gene

Post-translational modifications for GRIK1-AS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GRIK1-AS2 Gene

Domains & Families for GRIK1-AS2 Gene

Graphical View of Domain Structure for InterPro Entry

O14867

UniProtKB/Swiss-Prot:

BACH1_HUMAN :
  • Belongs to the bZIP family. CNC subfamily.
Family:
  • Belongs to the bZIP family. CNC subfamily.
genes like me logo Genes that share domains with GRIK1-AS2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for GRIK1-AS2 Gene

Function for GRIK1-AS2 Gene

Molecular function for GRIK1-AS2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.

Gene Ontology (GO) - Molecular Function for GRIK1-AS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IMP --
GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding IEA --
GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with GRIK1-AS2: view

Phenotypes for GRIK1-AS2 Gene

GenomeRNAi human phenotypes for GRIK1-AS2:
genes like me logo Genes that share phenotypes with GRIK1-AS2: view

Animal Model Products

Transcription Factor Targets for GRIK1-AS2 Gene

Selected GeneGlobe predicted Target genes for GRIK1-AS2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA and HOMER Transcription for GRIK1-AS2 Gene

Localization for GRIK1-AS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIK1-AS2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRIK1-AS2 gene
Compartment Confidence
extracellular 2
cytosol 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GRIK1-AS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IDA --
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with GRIK1-AS2: view

Pathways & Interactions for GRIK1-AS2 Gene

genes like me logo Genes that share pathways with GRIK1-AS2: view

Pathways by source for GRIK1-AS2 Gene

2 BioSystems pathways for GRIK1-AS2 Gene

Gene Ontology (GO) - Biological Process for GRIK1-AS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle IMP --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP --
GO:0006281 DNA repair IMP --
GO:0006302 double-strand break repair IEA --
GO:0006310 DNA recombination IEA --
genes like me logo Genes that share ontologies with GRIK1-AS2: view

No data available for SIGNOR curated interactions for GRIK1-AS2 Gene

Drugs & Compounds for GRIK1-AS2 Gene

No Compound Related Data Available

Transcripts for GRIK1-AS2 Gene

mRNA/cDNA for GRIK1-AS2 Gene

(3) Additional mRNA sequences :
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRIK1-AS2 Gene

GRIK1 antisense RNA 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRIK1-AS2 Gene

No ASD Table

Relevant External Links for GRIK1-AS2 Gene

GeneLoc Exon Structure for
GRIK1-AS2
ECgene alternative splicing isoforms for
GRIK1-AS2

Expression for GRIK1-AS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRIK1-AS2 Gene

Protein differential expression in normal tissues from HIPED for GRIK1-AS2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.7), Monocytes (12.4), and Testis (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRIK1-AS2 Gene



Protein tissue co-expression partners for GRIK1-AS2 Gene

SOURCE GeneReport for Unigene cluster for GRIK1-AS2 Gene:

Hs.659368
genes like me logo Genes that share expression patterns with GRIK1-AS2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRIK1-AS2 Gene

Orthologs for GRIK1-AS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIK1-AS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BACH1 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BACH1 35
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BACH1 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bach1 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BACH1 35
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BACH1 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves BACH1 35
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BACH1 35
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii bach1 35
  • 46 (a)
OneToMany
BACH1 (2 of 2) 35
  • 30 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta cnc 35
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
OneToMany
Species where no ortholog for GRIK1-AS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GRIK1-AS2 Gene

ENSEMBL:
Gene Tree for GRIK1-AS2 (if available)
TreeFam:
Gene Tree for GRIK1-AS2 (if available)

Paralogs for GRIK1-AS2 Gene

Paralogs for GRIK1-AS2 Gene

genes like me logo Genes that share paralogs with GRIK1-AS2: view

Variants for GRIK1-AS2 Gene

Sequence variations from dbSNP and Humsavar for GRIK1-AS2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000119200 -- 29,624,435(+) TAAAG(G/T)CATTG intron-variant
rs1000184149 -- 29,615,340(+) AGAGT(C/T)TTGCT intron-variant
rs1000242067 -- 29,609,349(+) ATAAA(A/G)TCAAT intron-variant
rs1000421437 -- 29,603,779(+) GTTGA(A/G)TGGAA intron-variant
rs1000542265 -- 29,610,515(+) GAAAG(A/C)TTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRIK1-AS2 Gene

Variant ID Type Subtype PubMed ID
esv2676813 CNV deletion 23128226
esv28655 CNV loss 19812545
esv3646802 CNV loss 21293372

Variation tolerance for GRIK1-AS2 Gene

Gene Damage Index Score: 0.40; 8.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRIK1-AS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRIK1-AS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIK1-AS2 Gene

Disorders for GRIK1-AS2 Gene

Relevant External Links for GRIK1-AS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRIK1-AS2

No disorders were found for GRIK1-AS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRIK1-AS2 Gene

Publications for GRIK1-AS2 Gene

  1. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4 64
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  3. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4 64
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for GRIK1-AS2 Gene

Sources for GRIK1-AS2 Gene

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