Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GRIK1 Gene

protein-coding   GIFtS: 69
GCID: GC21M030909

Glutamate Receptor, Ionotropic, Kainate 1


(Previous symbol: GLUR5)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
Glutamate Receptor, Ionotropic, Kainate 11 2     EEA32
GLUR51 2 3 5     GLR52
Excitatory Amino Acid Receptor 32 3     gluR-52
Glutamate Receptor 52 3     Glutamate Receptor Ionotropic, Kainate 12
EAA32 3     GluR-53
GluK12 3     GluR53
Human Glutamate Receptor (GLUR5)11     

External Ids:    HGNC: 45791   Entrez Gene: 28972   Ensembl: ENSG000001711897   OMIM: 1382455   UniProtKB: P390863   

Export aliases for GRIK1 gene to outside databases

Previous GC identifers: GC21M027486 GC21M029829 GC21M029831 GC21M016317


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GRIK1 Gene:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are
activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of
glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The
subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane
domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript
variants encoding different isoforms, has been noted for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for GRIK1 Gene: 
GRIK1 (glutamate receptor, ionotropic, kainate 1) is a protein-coding gene. Diseases associated with GRIK1 include monosomy 21, and juvenile absence epilepsy, and among its related super-pathways are Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell and Activation of Kainate Receptors upon glutamate binding. GO annotations related to this gene include extracellular-glutamate-gated ion channel activity and kainate selective glutamate receptor activity. An important paralog of this gene is GRIA3.

UniProtKB/Swiss-Prot: GRIK1_HUMAN, P39086
Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in
the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change,
leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse.
The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of
bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus

summary for GRIK1 Gene:
Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and
AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. The receptors
contribute to excitatory postsynaptic currents in many regions of the CNS and play a role in short- and
long-term synaptic plasticity. Kainate receptors consist of GluR5-7 and KA1-2 subunits. Each subunit has an
extracellular N-terminus, a cytoplasmic C-terminus, three membrane-spanning segments and a p-loop that dips
into the membrane from the cytoplasmic face to form the pore.

Gene Wiki entry for GRIK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NT_011512.11  NC_018932.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GRIK1 gene promoter:
         AML1a   FOXD3   POU2F1   POU2F1a   POU2F1b   FOXO1a   POU2F1c   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRIK1 promoter sequence

   Search SABiosciences Chromatin IP Primers for GRIK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRIK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q21.3   HGNC cytogenetic band: 21q22
Nature(405: 311-319) cytogenetic band:   21q22.11
GRIK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRIK1 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M030909:   GeneLoc Nature:405,311-319
Start:
30,909,254 bp from pter       16,502,382 bp from centromere
End:
31,312,351 bp from pter 16,888,900 bp from centromere
Size:
403,098 bases 386,519 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: L19058
genomic clones: R32A2 to P209L12


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GRIK1_HUMAN, P39086 (See protein sequence)
Recommended Name: Glutamate receptor ionotropic, kainate 1 precursor  
Size: 918 amino acids; 103981 Da
Subunit: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by
the dimerization of dimers (Probable). The unedited version (Q) assembles into a functional kainate-gated
homomeric channel, whereas the edited version (R) is unable to produce channel activity when expressed alone.
Both edited and unedited versions can form functional channels with GRIK4 and GRIK5. Interacts with KLHL17 (By
similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell
membrane; Multi-pass membrane protein
Rna editing: Modified_positions=636; Note=Partially edited
Miscellaneous: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to
their selective agonists. This receptor binds domoate > kainate > L-glutamate = quisqualate > CNQX = DNQX > AMPA
> dihydrokainate > NMDA
6/10 PDB 3D structures from and Proteopedia for GRIK1 (see all 10):
2ZNS (3D)        2ZNT (3D)        2ZNU (3D)        3FUZ (3D)        3FV1 (3D)        3FV2 (3D)    
Secondary accessions: Q13001 Q86SU9
Alternative splicing: 2 isoforms:  P39086-1   P39086-2   

Explore the universe of human proteins at neXtProt for GRIK1: NX_P39086

Explore proteomics data for GRIK1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P39086

  • GRIK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GRIK1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000821.1  NP_783300.1  

    ENSEMBL proteins: 
     ENSP00000327687   ENSP00000373777   ENSP00000382797   ENSP00000382798   ENSP00000373776  
     ENSP00000382791   ENSP00000382793   ENSP00000446326   ENSP00000311646  
    Reactome Protein details: P39086
    Human Recombinant Protein Products for GRIK1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GRIK1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for GRIK1
    GenScript Custom Purified and Recombinant Proteins Services for GRIK1
    Novus Biologicals GRIK1 Proteins
    Novus Biologicals GRIK1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GRIK1 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8260617
    GO:0016020membrane ----
    GO:0016021integral to membrane ----
    GO:0030054cell junction IEA--

    GRIK1 for ontologies           About GeneDecksing



    GRIK1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of GRIK1
    Browse R&D Systems for Antibodies
    OriGene Antibodies for GRIK1
    OriGene Custom Antibody Services for GRIK1
    GenScript Custom Superior Antibodies Services for GRIK1
    Novus Biologicals GRIK1 Antibodies
    Abcam antibodies for GRIK1
    Cloud-Clone Corp. Antibodies for GRIK1 
    ThermoFisher Antibodies for GRIK1
    LSBio Antibodies in human, mouse, rat for GRIK1 

    Assay Products for GRIK1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GRIK1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GRIK1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GRIK1 
    Cloud-Clone Corp. CLIAs for GRIK1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GRI: Ligand-gated ion channels / Glutamate receptors, ionotropic
    GR: Glutamate receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GluK1 
    Ionotropic glutamate receptors

    4 InterPro protein domains:
     IPR019594 Glu_rcpt_Glu/Gly-bd
     IPR001320 Iontro_glu_rcpt
     IPR001828 ANF_lig-bd_rcpt
     IPR001508 NMDA_rcpt

    Graphical View of Domain Structure for InterPro Entry P39086

    ProtoNet protein and cluster: P39086

    3 Blocks protein domains:
    IPB001320 Ionotropic glutamate receptor
    IPB001508 NMDA receptor signature
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GRIK1_HUMAN, P39086
    Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily


    GRIK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRIK1_HUMAN, P39086
    Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in
    the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change,
    leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse.
    The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of
    bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus

         Genatlas biochemistry entry for GRIK1:
    glutamate receptor K1,ionotropic,kainate (2-carboxy-4-(1-methylethenyl)-3-pyrrolidinacetic) class

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004970ionotropic glutamate receptor activity ----
    GO:0005215transporter activity ----
    GO:0005234extracellular-glutamate-gated ion channel activity IEA--
    GO:0005515protein binding ----
    GO:0015277kainate selective glutamate receptor activity IDA9335499
         
    GRIK1 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Grik1):
     behavior/neurological  growth/size  integument  nervous system  normal 

    GRIK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Grik1tm1Sfh for GRIK1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GRIK1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GRIK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRIK1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GRIK1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GRIK1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate GRIK1:
    hsa-miR-10b hsa-miR-10a
    SwitchGear 3'UTR luciferase reporter plasmidGRIK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GRIK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRIK1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GRIK1
    Sirion Biotech Customized adenovirus for overexpression of GRIK1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GRIK1 (see all 10)
    OriGene ORF clones in mouse, rat for GRIK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GRIK1 (NM_000830)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRIK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRIK1
    Sirion Biotech Customized lentivirus for stable overexpression of GRIK1 
                         Customized lentivirus expression plasmids for stable overexpression of GRIK1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GRIK1
    Search LifeMap BioReagents cell lines for GRIK1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIK1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GRIK1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.67
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    2Prostacyclin signalling through prostacyclin receptor
    Activation of Kainate Receptors upon glutamate binding0.70
    Activation of Ca-permeable Kainate Receptor0.33
    Ionotropic activity of Kainate Receptors0.33
    3CREB Pathway
    CREB Pathway0.68
    Intracellular Calcium Signaling0.50
    4Circadian entrainment
    Glutamatergic synapse0.39
    5Class A/1 (Rhodopsin-like receptors)
    Neuroactive ligand-receptor interaction0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for GRIK1
        Glutamic acid signaling

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GRIK1
        CREB Pathway
    Intracellular Calcium Signaling

    5/7        Reactome Pathways for GRIK1 (see all 7)
        Activation of Na-permeable Kainate Receptors
    Activation of Kainate Receptors upon glutamate binding
    Transmission across Chemical Synapses
    Activation of Ca-permeable Kainate Receptor
    Neuronal System


    2         Kegg Pathways  (Kegg details for GRIK1):
        Neuroactive ligand-receptor interaction
    Glutamatergic synapse


    GRIK1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRIK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for GRIK1 (P390863 ENSP000003827914) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SDCBPO005603, ENSP000002601304I2D: score=3 STRING: ENSP00000260130
    HOMER1Q86YM73, ENSP000003343824I2D: score=2 STRING: ENSP00000334382
    PICK1Q9NRD53, ENSP000003494654I2D: score=3 STRING: ENSP00000349465
    FLNAP213333, ENSP000003588664I2D: score=1 STRING: ENSP00000358866
    GRIP1Q9Y3R03, ENSP000003810984I2D: score=1 STRING: ENSP00000381098
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS8260617
    GO:0007215glutamate receptor signaling pathway TAS8260617
    GO:0007268synaptic transmission TAS--
    GO:0007399nervous system development TAS8260617
    GO:0007417central nervous system development TAS10580501

    GRIK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GRIK1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GRIK1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Domoic acid Potent, selective kainate agonist [14277-97-5]
    Kainic acidPotent excitant and neurotoxin[487-79-6]
    CNQXPotent AMPA/kainate antagonist[115066-14-3]
    UBP 302 Selective, potent kainate antagonist; active enantiomer of UBP 296 (Cat. No. 2078) [745055-91-8]
    ACETPotent antagonist of GluR5-containing kainate receptors[936095-50-0]

    1 HMDB Compound for GRIK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    TopiramateEpitomax (see all 5)97240-79-4--

    2 DrugBank Compounds for GRIK1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--9254673 13129570 17139284 10513575 17016423
    TopiramateTipiramate [French] (see all 3)97240-79-4targetantagonist19417176 11752352 15111016 12904467 12724156

    10/21 IUPHAR Ligands for GRIK1 (GluK1) (see all 21)    About this table 
    LigandTypeActionAffinityPubmed IDs
    [3H]UBP310
    NoneNone7.720837679
    LY466195
    AntagonistAntagonist7.7--
    domoic acid
    AgonistFull agonist7.7--
    ACET
    AntagonistAntagonist7.7--
    (S)-4-AHCP
    AgonistFull agonist7.7--
    [3H](2S,4R)-4-methylglutamate
    NoneNone7.7--
    MSVIII-19
    AntagonistAntagonist7.7--
    kainate
    AgonistFull agonist7.7--
    ATPA
    AgonistFull agonist7.7--
    LY339434
    AgonistFull agonist7.7--

    10/11 Novoseek inferred chemical compound relationships for GRIK1 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ly339434 93 4 10799698 (3)
    kainate 86.6 30 15857425 (3), 18606572 (2), 9076748 (1), 12533604 (1) (see all 20)
    atpa 81.6 4 12409614 (1), 18678878 (1)
    ly293558 78.2 2 8609884 (2)
    glutamate 76.5 44 19941835 (2), 1977421 (2), 10627597 (2), 7523595 (1) (see all 26)
    cyclothiazide 68.5 1 7506043 (1)
    nmda 56.3 12 8915893 (1), 8609884 (1), 14969737 (1), 18678878 (1) (see all 6)
    nbqx 49.5 2 8609884 (1)
    gaba 30.9 3 19406109 (1), 18678878 (1)
    calcium 5.29 2 12533604 (1), 19588945 (1)

    Search CenterWatch for drugs/clinical trials and news about GRIK1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GRIK1 gene (2 alternative transcripts): 
    NM_000830.3  NM_175611.2  

    Unigene Cluster for GRIK1:

    Glutamate receptor, ionotropic, kainate 1
    Hs.664641  [show with all ESTs]
    Unigene Representative Sequence: NM_175611
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327783 ENST00000389125 ENST00000399913 ENST00000399914(uc002ynn.3 uc011acs.2 uc011act.2 uc010glq.1)
    ENST00000389124 ENST00000399907(uc002yno.1) ENST00000399909 ENST00000472429(uc002ynr.3)
    ENST00000535441 ENST00000309434

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GRIK1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate GRIK1:
    hsa-miR-10b hsa-miR-10a
    SwitchGear 3'UTR luciferase reporter plasmidGRIK1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GRIK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRIK1
    Clone
    Products:
         
    OriGene clones in human, mouse for GRIK1 (see all 10)
    OriGene ORF clones in mouse, rat for GRIK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GRIK1 (NM_000830)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRIK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRIK1
    Sirion Biotech Customized lentivirus for stable overexpression of GRIK1 
                         Customized lentivirus expression plasmids for stable overexpression of GRIK1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GRIK1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GRIK1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRIK1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRIK1

    Additional mRNA sequence: 

    AJ249208.1 AK294353.1 AK296404.1 BC028238.1 L19058.1 U16125.1 

    3 DOTS entries:

    DT.87046312  DT.111611  DT.203260 

    20 AceView cDNA sequences:

    L19058 U16125 AA401282 BC028238 NM_175611 NM_000830 BX953961 Z43823 
    F03081 AI497899 AK095150 AA834605 AI659715 AJ249208 BF910983 R40795 
    BI913119 R19110 R44776 BG221225 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GRIK1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                                                          -                                                               
    SP2:                                                                          -     -                                               -         
    SP3:                                                                                                                                          
    SP4:                          -                                                                                                               


    ECgene alternative splicing isoforms for GRIK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GRIK1 expression in normal human tissues (normalized intensities)      GRIK1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGAACTGG
    GRIK1 Expression
    About this image


    GRIK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Thalamus
             midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Kidney (Urinary System)
             Ureteric Bud

    See GRIK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GRIK1

    SOURCE GeneReport for Unigene cluster: Hs.664641

    UniProtKB/Swiss-Prot: GRIK1_HUMAN, P39086
    Tissue specificity: Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus

        SABiosciences Expression via Pathway-Focused PCR Arrays including GRIK1: 
              Neurotransmitter Receptors in human mouse rat
              GABA & Glutamate in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for GRIK1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GRIK1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRIK1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRIK1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GRIK1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grik11 , 5 glutamate receptor, ionotropic, kainate 11, 5 90.98(n)1
    97.79(a)1
      16 (50.23 cM)5
    148051  NM_010348.31  NP_034478.11 
     878961965 
    chicken
    (Gallus gallus)
    Aves GRIK11 glutamate receptor, ionotropic, kainate 1 85.1(n)
    95.18(a)
      418489  XM_416697.3  XP_416697.3 
    lizard
    (Anolis carolinensis)
    Reptilia GRIK16
    glutamate receptor, ionotropic, kainate 1
    87(a)
    1 ↔ 1
    3(146163160-146416553)
    zebrafish
    (Danio rerio)
    Actinopterygii wufv36b032 wufv36b03 79.69(n)   334570  BM071990.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG111553
    CG38221
    kainate selective glutamate receptor3
    CG38221
    56(a)
    (best of 10)3
    56.52(n)1
    51.38(a)1
      424731  NM_142668.21  NP_650925.11 


    ENSEMBL Gene Tree for GRIK1 (if available)
    TreeFam Gene Tree for GRIK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GRIK1 gene
    GRIA32  GRIN2D2  GRIA22  GRIN12  GRIK22  GRIA12  GRIK42  GRIK32  
    GRIN3A2  GRIN2B2  GRIN2A2  GRIK52  GRIN3B2  GRIA42  GRIN2C2  GRID12  
    GRID22  
    12 SIMAP similar genes for GRIK1 using alignment to 9 protein entries:     GRIK1_HUMAN (see all proteins):
    GLUR5    GRIK3    GRIK2    GRIK5    GRIK4    GRIA1
    GRIA2    GRIA4    GRIA3    GRID2    GRIN2A    GRID1

    GRIK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7952 SNPs in GRIK1 are shown (see all 7952)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0127524
    ----see VAR_0127522 R Q mis40--------
    VAR_0003044
    ----see VAR_0003042 Q R mis40--------
    rs713350931,2
    C--16559865(+) TATGGTG/-TGTGT 2 -- int11Minor allele frequency- -:0.50NA 2
    rs58433921,2
    C--21496110(+) ACAGT-/CTCTCTC 2 -- int1 trp31Minor allele frequency- CT:0.00NA 2
    rs3703450061,2
    C--21751612(+) AAACT-/GTTCCTT 2 -- int10--------
    rs81292061,2
    C,A--30908788(+) gccatA/Gtggaa 1 -- ds50010--------
    rs1447165271,2
    --30908813(+) AACCTC/GTTTTT 1 -- ds50010--------
    rs601932201,2
    C--30908942(+) GTGGCG/AAACAC 1 -- ds50012Minor allele frequency- A:0.05WA 120
    rs1485379621,2
    C--30908945(+) GCGAAC/TACCTT 1 -- ds50010--------
    rs1453282991,2
    --30908993(+) TCCAGC/TGCACT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for GRIK1 (30909254 - 31159254 bp, first 250kb of GRIK1)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for GRIK1 (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1010713CNV Deletion20482838
    esv2667733CNV Deletion23128226
    esv2676813CNV Deletion23128226
    esv2671877CNV Deletion23128226
    esv2660792CNV Deletion23128226
    esv1004829CNV Insertion20482838
    esv2540796CNV Insertion19546169
    esv269135CNV Insertion20981092
    esv28655CNV Loss19812545
    nsv913674CNV Loss21882294


    Human Gene Mutation Database (HGMD): GRIK1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GRIK1
    DNA2.0 Custom Variant and Variant Library Synthesis for GRIK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 138245    OMIM disorders: --

    20/39 diseases for GRIK1 (see all 39):    About MalaCards
    monosomy 21    juvenile absence epilepsy    childhood absence epilepsy    paraneoplastic syndromes
    fragile x syndrome    toxic encephalopathy    attention deficit hyperactivity disorder    tetanus
    temporal lobe epilepsy    major depressive disorder    down syndrome    mood disorder
    alcohol dependence    brain disease    brain injury    intellectual disability
    schizophrenia    medulloblastoma    pertussis    amyotrophic lateral sclerosis

    15 diseases from the University of Copenhagen DISEASES database for GRIK1:
    Toxic encephalopathy     Schizophrenia     Fragile X syndrome     Parkinson's disease
    Alzheimer's disease     Huntington's disease     Cerebrovascular accident     Amyotrophic lateral sclerosis
    Encephalitis     Intellectual disability     Depersonalization disorder     Amnestic disorder
    Autistic disorder     Tetanus     Brain ischemia

    GRIK1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    7 Novoseek inferred disease relationships for GRIK1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    childhood absence epilepsy 63.2 2 11920863 (1), 9259378 (1)
    epilepsy temporal lobe 37.3 4 19941835 (2), 9848088 (1)
    monosomy 35.9 1 7959697 (1)
    schizophrenia 30.1 3 11702055 (2), 14969737 (1)
    epilepsy 14.8 4 18606572 (2), 15857425 (1)
    down syndrome 11.5 1 7959697 (1)
    neurological disorders 4.38 1 11241583 (1)

    Genetic Association Database (GAD): GRIK1
    Human Genome Epidemiology (HuGE) Navigator: GRIK1 (15 documents)

    Export disorders for GRIK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GRIK1 gene, integrated from 9 sources (see all 119):
    (articles sorted by number of sources associating them with GRIK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia. (PubMed id 11702055)1, 2, 4, 9 Shibata H.... Fukumaki Y. (2001)
    2. Allelic association of juvenile absence epilepsy with a GluR5 kainate receptor gene (GRIK1) polymorphism. (PubMed id 9259378)1, 4, 9 Sander T....Janz D. (1997)
    3. A preliminary pharmacogenetic investigation of adverse events from topiramate in heavy drinkers. (PubMed id 19331489)1, 4, 9 Ray L.A....Monti P.M. (2009)
    4. cDNA cloning and functional properties of human glutamate receptor EAA3 (GluR5) in homomeric and heteromeric configuration. (PubMed id 8589992)1, 2, 9 Korczak B.... Kamboj R.K. (1995)
    5. Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6. (PubMed id 8260617)1, 2, 9 Gregor P.... Uhl G.R. (1993)
    6. A novel locus for body mass index on 5p15.2: a meta-an alysis of two genome-wide association studies. (PubMed id 22446040)1, 4 Wang K.S....Callahan K. (2012)
    7. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    8. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    10. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2897 HGNC: 4579 AceView: GRIK1 Ensembl:ENSG00000171189 euGenes: HUgn2897
    ECgene: GRIK1 Kegg: 2897 H-InvDB: GRIK1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GRIK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GRIK1 gene:
    Search GeneIP for patents involving GRIK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of GRIK1
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GRIK1   OriGene RNAi products in human, mouse, rat for GRIK1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for GRIK1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GRIK1  
     OriGene qSTAR qPCR primer pairs in human, mouse for GRIK1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GRIK1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GRIK1   OriGene Custom Protein Services for GRIK1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GRIK1
     QIAGEN SeqTarget long-range PCR primers for resequencing GRIK1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRIK1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRIK1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRIK1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRIK1
     GenScript Custom Purified and Recombinant Proteins Services for GRIK1 GenScript cDNA clones with any tag delivered in your preferred vector for GRIK1
     GenScript Custom Assay Services for GRIK1 GenScript Custom Superior Antibodies Services for GRIK1
     GenScript Custom overexpressing Cell Line Services for GRIK1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in GRIK1 promoter
     Search Chromatin IP Primers for GRIK1
     RT2 qPCR Primer Assay in human, mouse, rat GRIK1
     GNC Network for GRIK1
     SABiosciences PCR Arrays including human, mouse, rat GRIK1
     Tocris compounds for GRIK1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GRIK1 antibodies
     GRIK1 proteins
     GRIK1 lysates
     Antibodies for GRIK1
     See all of Abcam's Antibodies, Kits and Proteins for GRIK1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for GRIK1
     Antibodies for GRIK1
     ELISAs for GRIK1
     CLIAs for GRIK1
     Search LifeMap BioReagents cell lines for GRIK1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIK1
     SwitchGear 3'UTR luciferase reporter plasmids for GRIK1
     SwitchGear Promoter luciferase reporter plasmids for GRIK1
     ThermoFisher Antibodies for GRIK1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRIK1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GRIK1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GRIK1
    Customized:
     lentivirus for stable overexpression of GRIK1
     lentivirus expression plasmids for stable overexpression of GRIK1
     adenovirus for overexpression of GRIK1
     LSBio Antibodies in human, mouse, rat for GRIK1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GRIK1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4