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Aliases for GRIK1 Gene

Aliases for GRIK1 Gene

  • Glutamate Receptor, Ionotropic, Kainate 1 2 3
  • GLUR5 3 4 6
  • Excitatory Amino Acid Receptor 3 3 4
  • Glutamate Receptor 5 3 4
  • GluR-5 3 4
  • GluK1 3 4
  • EAA3 3 4
  • Glutamate Receptor Ionotropic, Kainate 1 3
  • EEA3 3
  • GLR5 3

External Ids for GRIK1 Gene

Previous HGNC Symbols for GRIK1 Gene

  • GLUR5

Previous GeneCards Identifiers for GRIK1 Gene

  • GC21M027486
  • GC21M029829
  • GC21M029831
  • GC21M030909
  • GC21M016317

Summaries for GRIK1 Gene

Entrez Gene Summary for GRIK1 Gene

  • Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRIK1 Gene

GRIK1 (Glutamate Receptor, Ionotropic, Kainate 1) is a Protein Coding gene. Diseases associated with GRIK1 include depersonalization disorder and amnestic disorder. Among its related pathways are CREB Pathway and CREB Pathway. GO annotations related to this gene include extracellular-glutamate-gated ion channel activity and kainate selective glutamate receptor activity. An important paralog of this gene is GRID2.

UniProtKB/Swiss-Prot for GRIK1 Gene

  • Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus

Tocris Summary for GRIK1 Gene

  • Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. The receptors contribute to excitatory postsynaptic currents in many regions of the CNS and play a role in short- and long-term synaptic plasticity. Kainate receptors consist of GluR5-7 and KA1-2 subunits. Each subunit has an extracellular N-terminus, a cytoplasmic C-terminus, three membrane-spanning segments and a p-loop that dips into the membrane from the cytoplasmic face to form the pore.

Gene Wiki entry for GRIK1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIK1 Gene

Genomics for GRIK1 Gene

Regulatory Elements for GRIK1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GRIK1 Gene

Start:
29,536,933 bp from pter
End:
29,940,033 bp from pter
Size:
403,101 bases
Orientation:
Minus strand

Genomic View for GRIK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRIK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIK1 Gene

Proteins for GRIK1 Gene

  • Protein details for GRIK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P39086-GRIK1_HUMAN
    Recommended name:
    Glutamate receptor ionotropic, kainate 1
    Protein Accession:
    P39086
    Secondary Accessions:
    • Q13001
    • Q86SU9

    Protein attributes for GRIK1 Gene

    Size:
    918 amino acids
    Molecular mass:
    103981 Da
    Quaternary structure:
    • Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers (Probable). The unedited version (Q) assembles into a functional kainate-gated homomeric channel, whereas the edited version (R) is unable to produce channel activity when expressed alone. Both edited and unedited versions can form functional channels with GRIK4 and GRIK5. Interacts with KLHL17 (By similarity).
    Miscellaneous:
    • The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate > L-glutamate = quisqualate > CNQX = DNQX > AMPA > dihydrokainate > NMDA

    Three dimensional structures from OCA and Proteopedia for GRIK1 Gene

    Alternative splice isoforms for GRIK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRIK1 Gene

Proteomics data for GRIK1 Gene at MOPED

Post-translational modifications for GRIK1 Gene

  • Glycosylation at Asn68, Asn74, Asn276, Asn379, Asn428, Asn439, Asn446, and Asn561
  • Modification sites at PhosphoSitePlus

Other Protein References for GRIK1 Gene

No data available for DME Specific Peptides for GRIK1 Gene

Domains for GRIK1 Gene

Gene Families for GRIK1 Gene

HGNC:
  • GR :Glutamate receptors
  • GRI :Ligand-gated ion channels / Glutamate receptors, ionotropic
IUPHAR :

Suggested Antigen Peptide Sequences for GRIK1 Gene

Graphical View of Domain Structure for InterPro Entry

P39086

UniProtKB/Swiss-Prot:

GRIK1_HUMAN :
  • P39086
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily.
genes like me logo Genes that share domains with GRIK1: view

Function for GRIK1 Gene

Molecular function for GRIK1 Gene

GENATLAS Biochemistry: glutamate receptor K1,ionotropic,kainate (2-carboxy-4-(1-methylethenyl)-3-pyrrolidinacetic) class
UniProtKB/Swiss-Prot Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus

Gene Ontology (GO) - Molecular Function for GRIK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004970 ionotropic glutamate receptor activity --
GO:0005234 extracellular-glutamate-gated ion channel activity IBA --
GO:0005515 protein binding --
GO:0015277 kainate selective glutamate receptor activity IDA 9335499
genes like me logo Genes that share ontologies with GRIK1: view
genes like me logo Genes that share phenotypes with GRIK1: view

Animal Models for GRIK1 Gene

MGI Knock Outs for GRIK1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRIK1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GRIK1 Gene

Localization for GRIK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIK1 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRIK1 Gene COMPARTMENTS Subcellular localization image for GRIK1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
extracellular 3
nucleus 3
cytosol 2
endoplasmic reticulum 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for GRIK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8260617
GO:0014069 postsynaptic density --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with GRIK1: view

Pathways for GRIK1 Gene

genes like me logo Genes that share pathways with GRIK1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GRIK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8260617
GO:0007215 glutamate receptor signaling pathway TAS 8260617
GO:0007268 synaptic transmission TAS --
GO:0007399 nervous system development TAS 8260617
GO:0007417 central nervous system development TAS 10580501
genes like me logo Genes that share ontologies with GRIK1: view

Compounds for GRIK1 Gene

(5) Tocris Compounds for GRIK1 Gene

Compound Action Cas Number
ACET Potent antagonist of GluR5-containing kainate receptors [936095-50-0]
ATPA Selective, potent GluR5 agonist [140158-50-5]
CNQX Potent AMPA/kainate antagonist [115066-14-3]
Kainic acid Potent excitant and neurotoxin [487-79-6]
UBP 310 GLUK5 antagonist [902464-46-4]

(1) HMDB Compounds for GRIK1 Gene

Compound Synonyms Cas Number PubMed IDs
Topiramate
  • Epitomax
97240-79-4

(2) Drugbank Compounds for GRIK1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target
Topiramate
  • Tipiramate [French]
97240-79-4 target antagonist

(21) IUPHAR Ligand for GRIK1 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]UBP310 None None 6.3
SYM2081 Inhibitor Inhibition 5.5
LY466195 Antagonist Antagonist
domoic acid Agonist Full agonist
ACET Antagonist Antagonist
(S)-4-AHCP Agonist Full agonist
[3H](2S,4R)-4-methylglutamate None None
MSVIII-19 Antagonist Antagonist
kainate Agonist Full agonist
ATPA Agonist Full agonist
LY339434 Agonist Full agonist
NS3763 Antagonist Antagonist
LY382884 Antagonist Antagonist
concanavalin A Allosteric regulator Positive
8-deoxy-neodysiherbaine Agonist Full agonist
dysiherbaine Agonist Full agonist
[3H]kainate None None
2,4-epi-neodysiherbaine Antagonist Antagonist
UBP302 Antagonist Antagonist
UBP310 Antagonist Antagonist
(S)-5-iodowillardiine Agonist Agonist

(11) Novoseek inferred chemical compound relationships for GRIK1 Gene

Compound -log(P) Hits PubMed IDs
ly339434 93 3
kainate 86.6 23
atpa 81.6 2
ly293558 78.2 2
glutamate 76.5 29
genes like me logo Genes that share compounds with GRIK1: view

Transcripts for GRIK1 Gene

Unigene Clusters for GRIK1 Gene

Glutamate receptor, ionotropic, kainate 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRIK1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for GRIK1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIK1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: -
SP2: - - -
SP3:
SP4: -

Relevant External Links for GRIK1 Gene

GeneLoc Exon Structure for
GRIK1
ECgene alternative splicing isoforms for
GRIK1

Expression for GRIK1 Gene

mRNA expression in normal human tissues for GRIK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIK1 Gene

This gene is overexpressed in Brain - Hypothalamus (6.9), Brain - Hippocampus (5.4), Brain - Anterior cingulate cortex (BA24) (5.2), Brain - Amygdala (4.8), and Brain - Cortex (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GRIK1 Gene

SOURCE GeneReport for Unigene cluster for GRIK1 Gene Hs.664641

mRNA Expression by UniProt/SwissProt for GRIK1 Gene

P39086-GRIK1_HUMAN
Tissue specificity: Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus
genes like me logo Genes that share expressions with GRIK1: view

In Situ Assay Products

Orthologs for GRIK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRIK1 35
  • 99.64 (n)
  • 100 (a)
GRIK1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GRIK1 35
  • 92.23 (n)
  • 96.74 (a)
GRIK1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRIK1 35
  • 92.63 (n)
  • 96.56 (a)
GRIK1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grik1 35
  • 90.71 (n)
  • 97.78 (a)
Grik1 16
Grik1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRIK1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRIK1 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grik1 35
  • 90.56 (n)
  • 97.12 (a)
chicken
(Gallus gallus)
Aves GRIK1 35
  • 82.63 (n)
  • 91.16 (a)
GRIK1 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRIK1 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grik1 35
  • 79.68 (n)
  • 92.26 (a)
zebrafish
(Danio rerio)
Actinopterygii GRIK1 (1 of 2) 36
  • 83 (a)
OneToMany
grik1a 36
  • 80 (a)
OneToMany
LOC561540 35
  • 76.56 (n)
  • 89.11 (a)
wufv36b03 35
fruit fly
(Drosophila melanogaster)
Insecta CG11155 35
  • 54.52 (n)
  • 49.38 (a)
CG3822 36
  • 49 (a)
ManyToMany
CG5621 36
  • 32 (a)
ManyToMany
clumsy 36
  • 32 (a)
ManyToMany
GluRIIA 36
  • 31 (a)
ManyToMany
GluRIIB 36
  • 27 (a)
ManyToMany
GluRIIC 36
  • 26 (a)
ManyToMany
GluRIIE 36
  • 34 (a)
ManyToMany
KaiRIA 36
  • 35 (a)
ManyToMany
CG4226 37
  • 28 (a)
clumsy 37
  • 37 (a)
CG3822 37
  • 48 (a)
CG15627 37
  • 32 (a)
Glu-RIIA 37
  • 32 (a)
CG5621 37
  • 37 (a)
Glu-RIIB 37
  • 28 (a)
CG9935 37
  • 43 (a)
Kai-RIA 37
  • 38 (a)
CG11155 37
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea glr-5 35
  • 48.08 (n)
  • 37.34 (a)
glr-4 37
  • 34 (a)
Species with no ortholog for GRIK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRIK1 Gene

ENSEMBL:
Gene Tree for GRIK1 (if available)
TreeFam:
Gene Tree for GRIK1 (if available)

Paralogs for GRIK1 Gene

Paralogs for GRIK1 Gene

genes like me logo Genes that share paralogs with GRIK1: view

Variants for GRIK1 Gene

Sequence variations from dbSNP and Humsavar for GRIK1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs51616 -- 29,898,009(+) AGTAA(C/T)TTGCC intron-variant
rs51617 -- 29,898,224(+) CCAGC(C/T)GCAAA intron-variant
rs55778 -- 29,724,680(-) TTCAT(C/T)ACTGT intron-variant
rs55780 -- 29,724,730(-) ACATA(C/T)GCTCT intron-variant
rs107032 -- 29,892,867(+) CTCCA(A/G/T)AACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRIK1 Gene

Variant ID Type Subtype PubMed ID
nsv834073 CNV Gain 17160897
nsv913674 CNV Loss 21882294
esv1004829 CNV Insertion 20482838
nsv528222 CNV Loss 19592680
esv2676813 CNV Deletion 23128226
esv28655 CNV Loss 19812545
esv1010713 CNV Deletion 20482838
nsv913675 CNV Gain 21882294
esv2671877 CNV Deletion 23128226
nsv834074 CNV Loss 17160897
esv2667733 CNV Deletion 23128226
esv2540796 CNV Insertion 19546169
esv269135 CNV Insertion 20981092
nsv470898 CNV Gain 18288195
nsv459235 CNV Gain 19166990
esv2660792 CNV Deletion 23128226
esv27684 CNV Loss 19812545

Relevant External Links for GRIK1 Gene

HapMap Linkage Disequilibrium report
GRIK1
Human Gene Mutation Database (HGMD)
GRIK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIK1 Gene

Disorders for GRIK1 Gene

(7) Novoseek inferred disease relationships for GRIK1 Gene

Disease -log(P) Hits PubMed IDs
childhood absence epilepsy 63.2 2
epilepsy temporal lobe 37.3 3
monosomy 35.9 1
schizophrenia 30.1 3
epilepsy 14.8 3

Relevant External Links for GRIK1

Genetic Association Database (GAD)
GRIK1
Human Genome Epidemiology (HuGE) Navigator
GRIK1
genes like me logo Genes that share disorders with GRIK1: view

No data available for UniProtKB/Swiss-Prot for GRIK1 Gene

Publications for GRIK1 Gene

  1. Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia. (PMID: 11702055) Shibata H. … Fukumaki Y. (Psychiatr. Genet. 2001) 3 4 23 48
  2. cDNA cloning and functional properties of human glutamate receptor EAA3 (GluR5) in homomeric and heteromeric configuration. (PMID: 8589992) Korczak B. … Kamboj R.K. (Recept. Channels 1995) 3 4 23
  3. Allelic association of juvenile absence epilepsy with a GluR5 kainate receptor gene (GRIK1) polymorphism. (PMID: 9259378) Sander T. … Janz D. (Am. J. Med. Genet. 1997) 3 23 48
  4. Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6. (PMID: 8260617) Gregor P. … Uhl G.R. (NeuroReport 1993) 3 4 23
  5. A preliminary pharmacogenetic investigation of adverse events from topiramate in heavy drinkers. (PMID: 19331489) Ray L.A. … Monti P.M. (Exp Clin Psychopharmacol 2009) 3 23 48

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