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GRIK1 Gene

protein-coding   GIFtS: 70
GCID: GC21M030909

Glutamate Receptor, Ionotropic, Kainate 1


(Previous symbol: GLUR5)
  See GRIK1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Glutamate Receptor, Ionotropic, Kainate 11 2     EEA32
GLUR51 2 3 5     GLR52
Excitatory Amino Acid Receptor 32 3     gluR-52
Glutamate Receptor 52 3     Glutamate Receptor Ionotropic, Kainate 12
EAA32 3     GluR-53
GluK12 3     GluR53
Human Glutamate Receptor (GLUR5)11     

External Ids:    HGNC: 45791   Entrez Gene: 28972   Ensembl: ENSG000001711897   OMIM: 1382455   UniProtKB: P390863   

Export aliases for GRIK1 gene to outside databases

Previous GC identifers: GC21M027486 GC21M029829 GC21M029831 GC21M016317


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GRIK1 Gene:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are
activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of
glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The
subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane
domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript
variants encoding different isoforms, has been noted for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for GRIK1 Gene:
GRIK1 (glutamate receptor, ionotropic, kainate 1) is a protein-coding gene. Diseases associated with GRIK1 include monosomy 21, and depersonalization disorder. GO annotations related to this gene include extracellular-glutamate-gated ion channel activity and kainate selective glutamate receptor activity. An important paralog of this gene is GRIA3.

UniProtKB/Swiss-Prot: GRIK1_HUMAN, P39086
Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in
the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change,
leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse.
The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of
bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus

summary for GRIK1 Gene:
Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and
AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. The receptors
contribute to excitatory postsynaptic currents in many regions of the CNS and play a role in short- and
long-term synaptic plasticity. Kainate receptors consist of GluR5-7 and KA1-2 subunits. Each subunit has an
extracellular N-terminus, a cytoplasmic C-terminus, three membrane-spanning segments and a p-loop that dips
into the membrane from the cytoplasmic face to form the pore.

Gene Wiki entry for GRIK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GRIK1 gene promoter:
         AML1a   FOXD3   POU2F1   POU2F1a   POU2F1b   FOXO1a   POU2F1c   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRIK1 promoter sequence

   Search Chromatin IP Primers for GRIK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRIK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q21.3   HGNC cytogenetic band: 21q22
Nature(405: 311-319) cytogenetic band:   21q22.11
GRIK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRIK1 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M030909:   GeneLoc Nature:405,311-319
Start:
30,909,254 bp from pter       16,502,382 bp from centromere
End:
31,312,351 bp from pter 16,888,900 bp from centromere
Size:
403,098 bases 386,519 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: L19058
genomic clones: R32A2 to P209L12


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GRIK1_HUMAN, P39086 (See protein sequence)
Recommended Name: Glutamate receptor ionotropic, kainate 1 precursor  
Size: 918 amino acids; 103981 Da
Subunit: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by
the dimerization of dimers (Probable). The unedited version (Q) assembles into a functional kainate-gated
homomeric channel, whereas the edited version (R) is unable to produce channel activity when expressed alone.
Both edited and unedited versions can form functional channels with GRIK4 and GRIK5. Interacts with KLHL17 (By
similarity)
Rna editing: Modified_positions=636; Note=Partially edited
Miscellaneous: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to
their selective agonists. This receptor binds domoate > kainate > L-glutamate = quisqualate > CNQX = DNQX > AMPA
> dihydrokainate > NMDA
Selected PDB 3D structures from and Proteopedia for GRIK1 (see all 10):
2ZNS (3D)        2ZNT (3D)        2ZNU (3D)        3FUZ (3D)        3FV1 (3D)        3FV2 (3D)    
Secondary accessions: Q13001 Q86SU9
Alternative splicing: 2 isoforms:  P39086-1   P39086-2   

Explore the universe of human proteins at neXtProt for GRIK1: NX_P39086

Explore proteomics data for GRIK1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn68, Asn74, Asn276, Asn379, Asn428, Asn439, Asn446, Asn561
  • Modification sites at PhosphoSitePlus

  • See GRIK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000821.1  NP_783300.1  

    ENSEMBL proteins: 
     ENSP00000327687   ENSP00000373777   ENSP00000382797   ENSP00000382798   ENSP00000373776  
     ENSP00000382791   ENSP00000382793   ENSP00000446326   ENSP00000311646  
    Reactome Protein details: P39086

    GRIK1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for GRIK1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GRI: Ligand-gated ion channels / Glutamate receptors, ionotropic
    GR: Glutamate receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GluK1
    Ionotropic glutamate receptors

    5 InterPro protein domains:
     IPR028082 Peripla_BP_I
     IPR019594 Glu_rcpt_Glu/Gly-bd
     IPR001320 Iontro_glu_rcpt
     IPR001828 ANF_lig-bd_rcpt
     IPR001508 NMDA_rcpt

    Graphical View of Domain Structure for InterPro Entry P39086

    ProtoNet protein and cluster: P39086

    3 Blocks protein domains:
    IPB001320 Ionotropic glutamate receptor
    IPB001508 NMDA receptor signature
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GRIK1_HUMAN, P39086
    Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily


    Find genes that share domains with GRIK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRIK1_HUMAN, P39086
    Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in
    the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change,
    leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse.
    The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of
    bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus

         Genatlas biochemistry entry for GRIK1:
    glutamate receptor K1,ionotropic,kainate (2-carboxy-4-(1-methylethenyl)-3-pyrrolidinacetic) class

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004970ionotropic glutamate receptor activity ----
    GO:0005215transporter activity ----
    GO:0005234extracellular-glutamate-gated ion channel activity IBA--
    GO:0005515protein binding ----
    GO:0015277kainate selective glutamate receptor activity IDA9335499
         
    Find genes that share ontologies with GRIK1           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Grik1):
     behavior/neurological  growth/size/body  integument  nervous system  normal 

    Find genes that share phenotypes with GRIK1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Grik1tm1Sfh for GRIK1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRIK1
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    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate GRIK1:
    hsa-miR-10b hsa-miR-10a
    SwitchGear 3'UTR luciferase reporter plasmidGRIK1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GRIK1_HUMAN, P39086: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell
    membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton3
    extracellular3
    nucleus3
    cytosol2
    endoplasmic reticulum2
    mitochondrion2

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8260617
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0030054cell junction IEA--

    Find genes that share ontologies with GRIK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GRIK1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1ADP signalling through P2Y purinoceptor 12
    Activation of Kainate Receptors upon glutamate binding0.68
    Activation of Na-permeable Kainate Receptors0.00
    Activation of Ca-permeable Kainate Receptor0.35
    Ionotropic activity of Kainate Receptors0.00
    2Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    3CREB Pathway
    CREB Pathway0.68
    Intracellular Calcium Signaling0.50
    4Circadian entrainment
    Glutamatergic synapse0.39
    5Peptide ligand-binding receptors
    Neuroactive ligand-receptor interaction0.36


    Find genes that share SuperPaths with GRIK1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GRIK1
        CREB Pathway
    Intracellular Calcium Signaling

    2 Reactome Pathways for GRIK1
        Activation of Na-permeable Kainate Receptors
    Activation of Ca-permeable Kainate Receptor


    2 Kegg Pathways  (Kegg details for GRIK1):
        Neuroactive ligand-receptor interaction
    Glutamatergic synapse

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRIK1: 
              Neurotransmitter Receptors in human mouse rat
              GABA & Glutamate in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GRIK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GRIK1 (P390863 ENSP000003827914) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SDCBPO005603, ENSP000002601304I2D: score=3 STRING: ENSP00000260130
    HOMER1Q86YM73, ENSP000003343824I2D: score=2 STRING: ENSP00000334382
    PICK1Q9NRD53, ENSP000003494654I2D: score=3 STRING: ENSP00000349465
    FLNAP213333, ENSP000003588664I2D: score=1 STRING: ENSP00000358866
    GRIP1Q9Y3R03, ENSP000003810984I2D: score=1 STRING: ENSP00000381098
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS8260617
    GO:0007215glutamate receptor signaling pathway TAS8260617
    GO:0007268synaptic transmission TAS--
    GO:0007399nervous system development TAS8260617
    GO:0007417central nervous system development TAS10580501

    Find genes that share ontologies with GRIK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for GRIK1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Domoic acid Potent, selective kainate agonist [14277-97-5]
    Kainic acidPotent excitant and neurotoxin[487-79-6]
    CNQXPotent AMPA/kainate antagonist[115066-14-3]
    UBP 302 Selective, potent kainate antagonist; active enantiomer of UBP 296 (Cat. No. 2078) [745055-91-8]
    ACETPotent antagonist of GluR5-containing kainate receptors[936095-50-0]

    1 HMDB Compound for GRIK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    TopiramateEpitomax (see all 5)97240-79-4--

    2 DrugBank Compounds for GRIK1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--9254673 13129570 17139284 10513575 17016423
    TopiramateTipiramate [French] (see all 3)97240-79-4targetantagonist19417176 11752352 15111016 12904467 12724156

    Selected IUPHAR Ligands for GRIK1 (GluK1) (see all 21)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]UBP310
    NoneNone7.720837679
    LY466195
    AntagonistAntagonist7.7--
    domoic acid
    AgonistFull agonist7.7--
    ACET
    AntagonistAntagonist7.7--
    (S)-4-AHCP
    AgonistFull agonist7.7--
    [3H](2S,4R)-4-methylglutamate
    NoneNone7.7--
    MSVIII-19
    AntagonistAntagonist7.7--
    kainate
    AgonistFull agonist7.7--
    ATPA
    AgonistFull agonist7.7--
    LY339434
    AgonistFull agonist7.7--

    Selected Novoseek inferred chemical compound relationships for GRIK1 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ly339434 93 4 10799698 (3)
    kainate 86.6 30 15857425 (3), 18606572 (2), 9076748 (1), 12533604 (1) (see all 20)
    atpa 81.6 4 12409614 (1), 18678878 (1)
    ly293558 78.2 2 8609884 (2)
    glutamate 76.5 44 19941835 (2), 1977421 (2), 10627597 (2), 7523595 (1) (see all 26)
    cyclothiazide 68.5 1 7506043 (1)
    nmda 56.3 12 8915893 (1), 8609884 (1), 14969737 (1), 18678878 (1) (see all 6)
    nbqx 49.5 2 8609884 (1)
    gaba 30.9 3 19406109 (1), 18678878 (1)
    calcium 5.29 2 12533604 (1), 19588945 (1)



    Find genes that share compounds with GRIK1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GRIK1 gene (2 alternative transcripts): 
    NM_000830.3  NM_175611.2  

    Unigene Cluster for GRIK1:

    Glutamate receptor, ionotropic, kainate 1
    Hs.664641  [show with all ESTs]
    Unigene Representative Sequence: NM_175611
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327783 ENST00000389125 ENST00000399913 ENST00000399914(uc002ynn.3 uc011acs.2 uc011act.2 uc010glq.1)
    ENST00000389124 ENST00000399907(uc002yno.1) ENST00000399909 ENST00000472429(uc002ynr.3)
    ENST00000535441 ENST00000309434
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    Additional mRNA sequence: 

    AJ249208.1 AK294353.1 AK296404.1 BC028238.1 L19058.1 U16125.1 

    3 DOTS entries:

    DT.87046312  DT.111611  DT.203260 

    20 AceView cDNA sequences:

    U16125 BC028238 L19058 NM_175611 AA401282 NM_000830 AI659715 Z43823 
    AJ249208 AA834605 F03081 BX953961 AK095150 AI497899 BF910983 R40795 
    BI913119 R19110 R44776 BG221225 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GRIK1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                                                          -                                                               
    SP2:                                                                          -     -                                               -         
    SP3:                                                                                                                                          
    SP4:                          -                                                                                                               


    ECgene alternative splicing isoforms for GRIK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GRIK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGAACTGG
    GRIK1 Expression
    About this image


    GRIK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Neurons
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Kidney (Urinary System)
             Ureteric Bud
     
     Eye (Sensory Organs)
             Glycinergic Amacrine Cells Inner Nuclear Layer
    GRIK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GRIK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.664641

    UniProtKB/Swiss-Prot: GRIK1_HUMAN, P39086
    Tissue specificity: Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRIK1: 
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              GABA & Glutamate in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GRIK1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grik11 , 5 glutamate receptor, ionotropic, kainate 11, 5 90.71(n)1
    97.78(a)1
      16 (50.23 cM)5
    148051  NM_146072.41  NP_666184.21 
     878961965 
    chicken
    (Gallus gallus)
    Aves GRIK11 glutamate receptor, ionotropic, kainate 1 82.63(n)
    91.16(a)
      418489  XM_004938378.1  XP_004938435.1 
    lizard
    (Anolis carolinensis)
    Reptilia GRIK16
    glutamate receptor, ionotropic, kainate 1
    88(a)
    1 ↔ 1
    3(146163160-146416553)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia grik11 glutamate receptor, ionotropic, kainate 1 79.68(n)
    92.26(a)
      100493949  XM_004912163.1  XP_004912220.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufv36b032 wufv36b03 79.69(n)   334570  BM071990.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG111551 , 3 kainate selective glutamate receptor3
    CG111551
    56(a)
    (best of 10)3
    54.52(n)1
    49.38(a)1
      438221  NM_143684.31  NP_651941.21 
    worm
    (Caenorhabditis elegans)
    Secernentea glr-43
    glr-51
    Glutamate receptor3
    glr-51
    34(a)3
    48.08(n)1
    37.34(a)1
      1792511  NM_072843.41  NP_505244.11 


    ENSEMBL Gene Tree for GRIK1 (if available)
    TreeFam Gene Tree for GRIK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GRIK1 gene
    GRIA32  GRIK52  GRIA22  GRIA42  GRIK22  GRID12  GRIA12  GRIK32  
    GRIK42  GRID22  
    12 SIMAP similar genes for GRIK1 using alignment to 9 protein entries:     GRIK1_HUMAN (see all proteins):
    GLUR5    GRIK3    GRIK2    GRIK5    GRIK4    GRIA1
    GRIA2    GRIA4    GRIA3    GRID2    GRIN2A    GRID1

    Find genes that share paralogs with GRIK1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GRIK1 (see all 7952)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs713350931,2
    C--16559865(+) TATGGTG/-TGTGT 2 -- int11Minor allele frequency- -:0.50NA 2
    rs58433921,2
    C--21496110(+) ACAGT-/CTCTCTC 2 -- int1 trp31Minor allele frequency- CT:0.00NA 2
    rs3703450061,2
    C--21751612(+) AAACT-/GTTCCTT 2 -- int10--------
    rs81292061,2
    C,A--30908788(+) gccatA/Gtggaa 1 -- ds50010--------
    rs1447165271,2
    --30908813(+) AACCTC/GTTTTT 1 -- ds50010--------
    rs601932201,2
    C--30908942(+) GTGGCG/AAACAC 1 -- ds50012Minor allele frequency- A:0.05WA 120
    rs1485379621,2
    C--30908945(+) GCGAAC/TACCTT 1 -- ds50010--------
    rs1453282991,2
    --30908993(+) TCCAGC/TGCACT 1 -- ds50010--------
    rs169843341,2
    C,F--30909025(+) TTTAAA/GCTATT 1 -- ds50014Minor allele frequency- G:0.05NA WA 260
    rs169843361,2
    C,F,H--30909029(+) AACTAT/CTTATA 1 -- ds50019Minor allele frequency- C:0.07NA NS EA 754

    HapMap Linkage Disequilibrium report for GRIK1 (30909254 - 31159254 bp, first 250kb of GRIK1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GRIK1 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1010713CNV Deletion20482838
    esv2667733CNV Deletion23128226
    esv2676813CNV Deletion23128226
    esv2671877CNV Deletion23128226
    esv2660792CNV Deletion23128226
    esv1004829CNV Insertion20482838
    esv2540796CNV Insertion19546169
    esv269135CNV Insertion20981092
    esv28655CNV Loss19812545
    nsv913674CNV Loss21882294

    Human Gene Mutation Database (HGMD): GRIK1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GRIK1
    DNA2.0 Custom Variant and Variant Library Synthesis for GRIK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138245    OMIM disorders: --

    4 diseases for GRIK1:    
    About MalaCards
    monosomy 21    depersonalization disorder    amnestic disorder    juvenile absence epilepsy

    15 diseases from the University of Copenhagen DISEASES database for GRIK1:
    Toxic encephalopathy     Schizophrenia     Fragile X syndrome     Parkinson's disease
    Alzheimer's disease     Huntington's disease     Cerebrovascular accident     Amyotrophic lateral sclerosis
    Encephalitis     Intellectual disability     Depersonalization disorder     Amnestic disorder
    Autistic disorder     Tetanus     Brain ischemia

    Find genes that share disorders with GRIK1           About GenesLikeMe

    7 Novoseek inferred disease relationships for GRIK1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    childhood absence epilepsy 63.2 2 11920863 (1), 9259378 (1)
    epilepsy temporal lobe 37.3 4 19941835 (2), 9848088 (1)
    monosomy 35.9 1 7959697 (1)
    schizophrenia 30.1 3 11702055 (2), 14969737 (1)
    epilepsy 14.8 4 18606572 (2), 15857425 (1)
    down syndrome 11.5 1 7959697 (1)
    neurological disorders 4.38 1 11241583 (1)

    Genetic Association Database (GAD): GRIK1
    Human Genome Epidemiology (HuGE) Navigator: GRIK1 (15 documents)

    Export disorders for GRIK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GRIK1 gene, integrated from 10 sources (see all 120):
    (articles sorted by number of sources associating them with GRIK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia. (PubMed id 11702055)1, 2, 4, 9 Shibata H.... Fukumaki Y. (Psychiatr. Genet. 2001)
    2. Allelic association of juvenile absence epilepsy with a GluR5 kainate receptor gene (GRIK1) polymorphism. (PubMed id 9259378)1, 4, 9 Sander T....Janz D. (Am. J. Med. Genet. 1997)
    3. A preliminary pharmacogenetic investigation of adverse events from topiramate in heavy drinkers. (PubMed id 19331489)1, 4, 9 Ray L.A....Monti P.M. (Exp Clin Psychopharmacol 2009)
    4. cDNA cloning and functional properties of human glutamate receptor EAA3 (GluR5) in homomeric and heteromeric configuration. (PubMed id 8589992)1, 2, 9 Korczak B.... Kamboj R.K. (Recept. Channels 1995)
    5. Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6. (PubMed id 8260617)1, 2, 9 Gregor P.... Uhl G.R. (NeuroReport 1993)
    6. A novel locus for body mass index on 5p15.2: a meta-analysis of two genome-wide association studies. (PubMed id 22446040)1, 4 Wang K.S....Callahan K. (Gene 2012)
    7. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    8. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder. (PubMed id 19095219)1, 4 Perlis R.H....Houston J.P. (Biol. Psychiatry 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2897 HGNC: 4579 AceView: GRIK1 Ensembl:ENSG00000171189 euGenes: HUgn2897
    ECgene: GRIK1 Kegg: 2897 H-InvDB: GRIK1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GRIK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GRIK1 gene:
    Search GeneIP for patents involving GRIK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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