Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GRIFIN Gene

Aliases for GRIFIN Gene

  • Galectin-Related Inter-Fiber Protein 2 3 4 5
  • Putative Grifin 3
  • Grifin 3

External Ids for GRIFIN Gene

Previous GeneCards Identifiers for GRIFIN Gene

  • GC00U990794
  • GC07M002482

Summaries for GRIFIN Gene

GeneCards Summary for GRIFIN Gene

GRIFIN (Galectin-Related Inter-Fiber Protein) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is LGALS4.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIFIN Gene

Genomics for GRIFIN Gene

Regulatory Elements for GRIFIN Gene

Enhancers for GRIFIN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G002476 1.2 Ensembl ENCODE 0.7 -0.9 -901 3.5 CBX3 RB1 ARID4B SIN3A ZNF48 RAD21 GLIS2 EGR1 ZNF143 FOS LFNG GRIFIN
GH07G002507 1.9 FANTOM5 Ensembl ENCODE dbSUPER 0.3 -33.8 -33824 6.0 FOXA2 ARID4B ZNF766 GLIS2 GATA2 FOS SP5 REST PPARG SMARCA4 LFNG BRAT1 GRIFIN
GH07G002471 1.1 Ensembl ENCODE 0.4 +5.4 5372 0.8 ELF3 FOXA2 PTBP1 ARID4B ZBTB7B RARA ETS1 GATA4 GATA2 FOS GRIFIN GC07P002406
GH07G002487 1.1 Ensembl ENCODE 0.4 -11.4 -11376 1.5 FOXA2 KLF17 ARID4B SIN3A GLI4 BMI1 GLIS2 EGR1 FOS EGR2 LFNG TTYH3 AMZ1 BRAT1 GRIFIN
GH07G002489 0.9 ENCODE 0.4 -13.2 -13246 1.3 HDAC1 SIN3A KLF17 TCF12 GLIS2 EGR1 ETV6 FOS RELB KDM4B LFNG TTYH3 AMZ1 GRIFIN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GRIFIN on UCSC Golden Path with GeneCards custom track

Genomic Location for GRIFIN Gene

Chromosome:
7
Start:
2,474,636 bp from pter
End:
2,476,894 bp from pter
Size:
2,259 bases
Orientation:
Minus strand

Genomic View for GRIFIN Gene

Genes around GRIFIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIFIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIFIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIFIN Gene

Proteins for GRIFIN Gene

  • Protein details for GRIFIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D1Z8-GRIFN_HUMAN
    Recommended name:
    Grifin
    Protein Accession:
    A4D1Z8
    Secondary Accessions:
    • A0A087WXP5

    Protein attributes for GRIFIN Gene

    Size:
    144 amino acids
    Molecular mass:
    15999 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=EAL23956.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for GRIFIN Gene

Post-translational modifications for GRIFIN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GRIFIN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRIFIN Gene

Domains & Families for GRIFIN Gene

Protein Domains for GRIFIN Gene

Suggested Antigen Peptide Sequences for GRIFIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A4D1Z8

UniProtKB/Swiss-Prot:

GRIFN_HUMAN :
  • The galectin domain is atypical and does not bind beta-galactoside sugars.
Domain:
  • The galectin domain is atypical and does not bind beta-galactoside sugars.
genes like me logo Genes that share domains with GRIFIN: view

No data available for Gene Families for GRIFIN Gene

Function for GRIFIN Gene

Gene Ontology (GO) - Molecular Function for GRIFIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with GRIFIN: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GRIFIN Gene

Localization for GRIFIN Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for GRIFIN Gene

Pathways & Interactions for GRIFIN Gene

SuperPathways for GRIFIN Gene

No Data Available

Interacting Proteins for GRIFIN Gene

Gene Ontology (GO) - Biological Process for GRIFIN Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GRIFIN Gene

Drugs & Compounds for GRIFIN Gene

No Compound Related Data Available

Transcripts for GRIFIN Gene

mRNA/cDNA for GRIFIN Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIFIN Gene

No ASD Table

Relevant External Links for GRIFIN Gene

GeneLoc Exon Structure for
GRIFIN
ECgene alternative splicing isoforms for
GRIFIN

Expression for GRIFIN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRIFIN Gene

mRNA differential expression in normal tissues according to GTEx for GRIFIN Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.6) and Skin - Not Sun Exposed (Suprapubic) (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of GRIFIN Gene:

GRIFIN

mRNA Expression by UniProt/SwissProt for GRIFIN Gene:

A4D1Z8-GRIFN_HUMAN
Tissue specificity: Not detected in lens.
genes like me logo Genes that share expression patterns with GRIFIN: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRIFIN Gene

Orthologs for GRIFIN Gene

Evolution for GRIFIN Gene

ENSEMBL:
Gene Tree for GRIFIN (if available)
TreeFam:
Gene Tree for GRIFIN (if available)

No data available for Orthologs for GRIFIN Gene

Paralogs for GRIFIN Gene

genes like me logo Genes that share paralogs with GRIFIN: view

Variants for GRIFIN Gene

Sequence variations from dbSNP and Humsavar for GRIFIN Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000350866 -- 2,476,695(+) CTGCT(A/C)CCCCA intron-variant, upstream-variant-2KB
rs1001101597 -- 2,473,418(+) TCTCC(A/G)TGTTG downstream-variant-500B
rs1001310919 -- 2,477,691(+) GTCGT(A/G)ACTGT upstream-variant-2KB
rs1001635760 -- 2,475,397(+) GCCGT(C/T)TCCAG intron-variant
rs1001909414 -- 2,476,079(+) CCCAT(A/C/T)TGTCC intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GRIFIN Gene

Variant ID Type Subtype PubMed ID
nsv1032737 CNV gain 25217958
nsv471216 CNV loss 18288195
nsv950792 CNV deletion 24416366

Relevant External Links for GRIFIN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRIFIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GRIFIN Gene

Disorders for GRIFIN Gene

Relevant External Links for GRIFIN

Genetic Association Database (GAD)
GRIFIN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRIFIN

No disorders were found for GRIFIN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRIFIN Gene

Publications for GRIFIN Gene

  1. A comparative gene expression profile of the whole eye from human, mouse, and guinea pig. (PMID: 18087242) Zhou X. … Qu J. (Mol. Vis. 2007) 2 3 4 64
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
  4. GRIFIN, a novel lens-specific protein related to the galectin family. (PMID: 9786891) Ogden A.T. … Lang R.A. (J. Biol. Chem. 1998) 2 3 64
  5. Interactions between small heat shock protein alpha-crystallin and galectin-related interfiber protein (GRIFIN) in the ocular lens. (PMID: 19296714) Barton K.A. … Petrash J.M. (Biochemistry 2009) 3 64

Products for GRIFIN Gene

Sources for GRIFIN Gene

Content
Loading form....