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Aliases for GRIFIN Gene

Aliases for GRIFIN Gene

  • Galectin-Related Inter-Fiber Protein 2 3 4 5
  • Putative Grifin 3
  • Grifin 3

External Ids for GRIFIN Gene

Previous GeneCards Identifiers for GRIFIN Gene

  • GC00U990794
  • GC07M002482

Summaries for GRIFIN Gene

GeneCards Summary for GRIFIN Gene

GRIFIN (Galectin-Related Inter-Fiber Protein) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is LGALS4.

Additional gene information for GRIFIN Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIFIN Gene

Genomics for GRIFIN Gene

Regulatory Elements for GRIFIN Gene

Enhancers for GRIFIN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H002476 1.1 Ensembl ENCODE 0.7 -0.9 -901 3.5 CTCF RB1 SAP130 ARID4B MAX ZIC2 RAD21 ZFHX2 GLIS2 CTBP1 LFNG GRIFIN
GH07H002471 0.9 Ensembl ENCODE 0.4 +5.4 5372 0.8 BCOR SMARCA5 TFAP4 PTBP1 SAP130 ZBTB7B ETS1 HDAC2 KDM1A GRIFIN GC07P002406
GH07H002451 1.2 Ensembl ENCODE 0.3 +24.8 24831 1.8 HDGF RB1 ARID4B SIN3A DMAP1 ZNF2 RAD21 SLC30A9 GLIS2 ZNF143 CHST12 BRAT1 IQCE LOC645357 EIF3B SNX8 TTYH3 AMZ1 LFNG GRIFIN
GH07H002468 0.8 ENCODE 0.4 +7.8 7834 0.2 CTCF RB1 KLF17 ZIC2 ZBTB7B RAD21 CC2D1A GLIS2 MTA3 PATZ1 GRIFIN GC07P002406
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GRIFIN on UCSC Golden Path with GeneCards custom track

Genomic Locations for GRIFIN Gene

Genomic Locations for GRIFIN Gene
2,259 bases
Minus strand

Genomic View for GRIFIN Gene

Genes around GRIFIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIFIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIFIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIFIN Gene

Proteins for GRIFIN Gene

  • Protein details for GRIFIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A0A087WXP5

    Protein attributes for GRIFIN Gene

    144 amino acids
    Molecular mass:
    15999 Da
    Quaternary structure:
    • Homodimer.
    • Sequence=EAL23956.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for GRIFIN Gene

Post-translational modifications for GRIFIN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GRIFIN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRIFIN Gene

Domains & Families for GRIFIN Gene

Gene Families for GRIFIN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GRIFIN Gene

Suggested Antigen Peptide Sequences for GRIFIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The galectin domain is atypical and does not bind beta-galactoside sugars.
  • The galectin domain is atypical and does not bind beta-galactoside sugars.
genes like me logo Genes that share domains with GRIFIN: view

Function for GRIFIN Gene

Phenotypes From GWAS Catalog for GRIFIN Gene

Gene Ontology (GO) - Molecular Function for GRIFIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with GRIFIN: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GRIFIN Gene

Localization for GRIFIN Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GRIFIN Gene

Pathways & Interactions for GRIFIN Gene

SuperPathways for GRIFIN Gene

No Data Available

Interacting Proteins for GRIFIN Gene

Gene Ontology (GO) - Biological Process for GRIFIN Gene


No data available for Pathways by source and SIGNOR curated interactions for GRIFIN Gene

Drugs & Compounds for GRIFIN Gene

No Compound Related Data Available

Transcripts for GRIFIN Gene


(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIFIN Gene

No ASD Table

Relevant External Links for GRIFIN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRIFIN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRIFIN Gene

mRNA differential expression in normal tissues according to GTEx for GRIFIN Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.6) and Skin - Not Sun Exposed (Suprapubic) (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of GRIFIN Gene:


mRNA Expression by UniProt/SwissProt for GRIFIN Gene:

Tissue specificity: Not detected in lens.
genes like me logo Genes that share expression patterns with GRIFIN: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRIFIN Gene

Orthologs for GRIFIN Gene

Evolution for GRIFIN Gene

Gene Tree for GRIFIN (if available)
Gene Tree for GRIFIN (if available)

No data available for Orthologs for GRIFIN Gene

Paralogs for GRIFIN Gene

genes like me logo Genes that share paralogs with GRIFIN: view

Variants for GRIFIN Gene

Sequence variations from dbSNP and Humsavar for GRIFIN Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000350866 -- 2,476,695(+) CTGCT(A/C)CCCCA intron-variant, upstream-variant-2KB
rs1001101597 -- 2,473,418(+) TCTCC(A/G)TGTTG downstream-variant-500B
rs1001310919 -- 2,477,691(+) GTCGT(A/G)ACTGT upstream-variant-2KB
rs1001635760 -- 2,475,397(+) GCCGT(C/T)TCCAG intron-variant
rs1001909414 -- 2,476,079(+) CCCAT(A/C/T)TGTCC intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GRIFIN Gene

Variant ID Type Subtype PubMed ID
nsv950792 CNV deletion 24416366
nsv471216 CNV loss 18288195
nsv1032737 CNV gain 25217958

Relevant External Links for GRIFIN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GRIFIN Gene

Disorders for GRIFIN Gene

Relevant External Links for GRIFIN

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GRIFIN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRIFIN Gene

Publications for GRIFIN Gene

  1. A comparative gene expression profile of the whole eye from human, mouse, and guinea pig. (PMID: 18087242) Zhou X … Qu J (Molecular vision 2007) 2 3 4 60
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 60
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 60
  4. GRIFIN, a novel lens-specific protein related to the galectin family. (PMID: 9786891) Ogden AT … Lang RA (The Journal of biological chemistry 1998) 2 3 60
  5. Interactions between small heat shock protein alpha-crystallin and galectin-related interfiber protein (GRIFIN) in the ocular lens. (PMID: 19296714) Barton KA … Petrash JM (Biochemistry 2009) 3 60

Products for GRIFIN Gene

Sources for GRIFIN Gene

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