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Aliases for GRID2IP Gene

Aliases for GRID2IP Gene

  • Grid2 Interacting Protein 2 3 5
  • Glutamate Receptor, Ionotropic, Delta 2 (Grid2) Interacting Protein 1 2 3
  • Glutamate Receptor, Ionotropic, Delta 2-Interacting Protein 1 3 4
  • Glutamate Receptor, Ionotropic, Delta 2 (Grid2) Interacting Protein 2
  • DELPHILIN 3

External Ids for GRID2IP Gene

Previous GeneCards Identifiers for GRID2IP Gene

  • GC07M006311
  • GC07U901586
  • GC07M006507

Summaries for GRID2IP Gene

Entrez Gene Summary for GRID2IP Gene

  • Glutamate receptor delta-2 (GRID2; MIM 602368) is predominantly expressed at parallel fiber-Purkinje cell postsynapses and plays crucial roles in synaptogenesis and synaptic plasticity. GRID2IP1 interacts with GRID2 and may control GRID2 signaling in Purkinje cells (Matsuda et al., 2006 [PubMed 16835239]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GRID2IP Gene

GRID2IP (Grid2 Interacting Protein) is a Protein Coding gene. An important paralog of this gene is DIAPH1.

UniProtKB/Swiss-Prot for GRID2IP Gene

  • Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRID2IP Gene

Genomics for GRID2IP Gene

Regulatory Elements for GRID2IP Gene

Enhancers for GRID2IP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G006530 1.1 Ensembl ENCODE 13.4 +20.0 20022 1.8 FOXA2 CBX3 PKNOX1 NFIB KLF17 ARID4B SIN3A RARA GLIS2 CBX5 GRID2IP ZDHHC4 ZNF12 LOC101927325
GH07G006525 0.8 Ensembl 13.4 +24.7 24716 1.8 CTCF FOXA2 RB1 RBBP5 ZNF48 RAD21 RARA ZFHX2 EGR1 SMC3 ZDHHC4 GRID2IP ENSG00000232581 C7orf26 LOC101927325
GH07G006502 1.2 Ensembl ENCODE 7.2 +47.4 47423 2.6 PKNOX1 MLX SIN3A ARID4B ZBTB7B TCF12 ZNF121 GLIS2 ZNF143 SP3 KDELR2 GRID2IP LOC101927325 RPL31P34
GH07G006481 1.1 ENCODE 6.8 +67.8 67781 4.4 FOXA2 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS ZHX2 SMARCB1 ZNF316 KDELR2 C7orf26 ANKRD61 USP42 GRID2IP DAGLB GC07M006445
GH07G007166 0.7 dbSUPER 4.5 -616.2 -616191 2.9 RFX1 TAL1 HLF CHD1 ZBTB40 ZBTB7A TCF12 POLR2A ZKSCAN8 FOXJ2 C1GALT1 GRID2IP ENSG00000244167
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GRID2IP on UCSC Golden Path with GeneCards custom track

Genomic Location for GRID2IP Gene

Chromosome:
7
Start:
6,496,778 bp from pter
End:
6,551,436 bp from pter
Size:
54,659 bases
Orientation:
Minus strand

Genomic View for GRID2IP Gene

Genes around GRID2IP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRID2IP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRID2IP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRID2IP Gene

Proteins for GRID2IP Gene

  • Protein details for GRID2IP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D2P6-GRD2I_HUMAN
    Recommended name:
    Delphilin
    Protein Accession:
    A4D2P6

    Protein attributes for GRID2IP Gene

    Size:
    1211 amino acids
    Molecular mass:
    132276 Da
    Quaternary structure:
    • Interacts with C-terminus of the glutamate receptor GRID2 via PDZ domain.
    SequenceCaution:
    • Sequence=EAL23724.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for GRID2IP Gene

Post-translational modifications for GRID2IP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GRID2IP Gene

No data available for DME Specific Peptides for GRID2IP Gene

Domains & Families for GRID2IP Gene

Gene Families for GRID2IP Gene

Protein Domains for GRID2IP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GRID2IP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GRID2IP: view

No data available for UniProtKB/Swiss-Prot for GRID2IP Gene

Function for GRID2IP Gene

Molecular function for GRID2IP Gene

UniProtKB/Swiss-Prot Function:
Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.

Phenotypes for GRID2IP Gene

genes like me logo Genes that share phenotypes with GRID2IP: view

Animal Models for GRID2IP Gene

MGI Knock Outs for GRID2IP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRID2IP Gene

Localization for GRID2IP Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRID2IP Gene

Cell junction, synapse, postsynaptic cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRID2IP gene
Compartment Confidence
plasma membrane 3
nucleus 3
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GRID2IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
GO:0043197 dendritic spine IEA --
GO:0045202 synapse IEA --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with GRID2IP: view

Pathways & Interactions for GRID2IP Gene

SuperPathways for GRID2IP Gene

No Data Available

Gene Ontology (GO) - Biological Process for GRID2IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060292 long term synaptic depression IEA --
genes like me logo Genes that share ontologies with GRID2IP: view

No data available for Pathways by source and SIGNOR curated interactions for GRID2IP Gene

Drugs & Compounds for GRID2IP Gene

No Compound Related Data Available

Transcripts for GRID2IP Gene

mRNA/cDNA for GRID2IP Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRID2IP Gene

Glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRID2IP Gene

No ASD Table

Relevant External Links for GRID2IP Gene

GeneLoc Exon Structure for
GRID2IP
ECgene alternative splicing isoforms for
GRID2IP

Expression for GRID2IP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRID2IP Gene

mRNA differential expression in normal tissues according to GTEx for GRID2IP Gene

This gene is overexpressed in Brain - Cerebellum (x7.4).

Protein differential expression in normal tissues from HIPED for GRID2IP Gene

This gene is overexpressed in Bone marrow stromal cell (37.3) and Serum (28.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRID2IP Gene



Protein tissue co-expression partners for GRID2IP Gene

NURSA nuclear receptor signaling pathways regulating expression of GRID2IP Gene:

GRID2IP

SOURCE GeneReport for Unigene cluster for GRID2IP Gene:

Hs.512174

Evidence on tissue expression from TISSUES for GRID2IP Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with GRID2IP: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRID2IP Gene

Orthologs for GRID2IP Gene

This gene was present in the common ancestor of animals.

Orthologs for GRID2IP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRID2IP 34 35
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia GRID2IP 34 35
  • 89.49 (n)
cow
(Bos Taurus)
Mammalia GRID2IP 34 35
  • 89.29 (n)
rat
(Rattus norvegicus)
Mammalia Grid2ip 34
  • 87.16 (n)
mouse
(Mus musculus)
Mammalia Grid2ip 34 16 35
  • 85.98 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 81 (a)
OneToMany
-- 35
  • 78 (a)
OneToMany
-- 35
  • 71 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia GRID2IP 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRID2IP 34 35
  • 71.82 (n)
lizard
(Anolis carolinensis)
Reptilia GRID2IP 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grid2ip 34
  • 63.55 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC561017 34
  • 61.47 (n)
grid2ipb 35
  • 50 (a)
OneToMany
grid2ipa 35
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea exc-6 35
  • 14 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9833 35
  • 31 (a)
OneToOne
Species where no ortholog for GRID2IP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRID2IP Gene

ENSEMBL:
Gene Tree for GRID2IP (if available)
TreeFam:
Gene Tree for GRID2IP (if available)

Paralogs for GRID2IP Gene

Paralogs for GRID2IP Gene

(1) SIMAP similar genes for GRID2IP Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GRID2IP: view

Variants for GRID2IP Gene

Sequence variations from dbSNP and Humsavar for GRID2IP Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000025927 -- 6,547,644(+) CTGGA(C/G)TTTGG intron-variant
rs1000074170 -- 6,528,981(+) CCCAG(A/G)CCTCA intron-variant
rs1000104534 -- 6,508,180(+) GCCAG(C/T)GCCTG intron-variant, reference, synonymous-codon
rs1000180692 -- 6,550,504(+) AAACA(C/G)AAGTG intron-variant
rs1000229441 -- 6,510,524(+) GCCTT(G/T)GCCTG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for GRID2IP Gene

Variant ID Type Subtype PubMed ID
dgv11172n54 CNV loss 21841781
esv1914954 OTHER inversion 16254605
esv3440661 CNV insertion 20981092
esv3612034 CNV loss 21293372
nsv1020236 CNV gain 25217958
nsv1026878 CNV loss 25217958
nsv1074067 CNV deletion 25765185
nsv1119107 CNV deletion 24896259
nsv436904 CNV insertion 17901297
nsv508444 CNV deletion 20534489
nsv515978 CNV loss 19592680
nsv7392 OTHER inversion 18451855
nsv830895 CNV loss 17160897

Variation tolerance for GRID2IP Gene

Gene Damage Index Score: 12.78; 94.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRID2IP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRID2IP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRID2IP Gene

Disorders for GRID2IP Gene

Relevant External Links for GRID2IP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRID2IP

No disorders were found for GRID2IP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRID2IP Gene

Publications for GRID2IP Gene

  1. Identification and characterization of human GRID2IP gene and rat Grid2ip gene in silico. (PMID: 14612983) Katoh M. … Katoh M. (Int. J. Mol. Med. 2003) 2 3 4 64
  2. Characterization of the delta2 glutamate receptor-binding protein delphilin: splicing variants with differential palmitoylation and an additional PDZ domain. (PMID: 16835239) Matsuda K. … Yuzaki M. (J. Biol. Chem. 2006) 3 4 64
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  4. Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts. (PMID: 25248455) Ek W.E. … D'Amato M. (Gut 2015) 3 64
  5. Binding of glutamate receptor delta2 to its scaffold protein, Delphilin, is regulated by PKA. (PMID: 17027646) Sonoda T. … Kawamoto S. (Biochem. Biophys. Res. Commun. 2006) 3 64

Products for GRID2IP Gene

Sources for GRID2IP Gene

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