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Aliases for GRID2IP Gene

Aliases for GRID2IP Gene

  • Grid2 Interacting Protein 2 3
  • Glutamate Receptor, Ionotropic, Delta 2 (Grid2) Interacting Protein 1 2 3
  • Glutamate Receptor, Ionotropic, Delta 2 (Grid2) Interacting Protein 2 5
  • Glutamate Receptor, Ionotropic, Delta 2-Interacting Protein 1 3 4

External Ids for GRID2IP Gene

Previous GeneCards Identifiers for GRID2IP Gene

  • GC07M006311
  • GC07U901586
  • GC07M006507

Summaries for GRID2IP Gene

Entrez Gene Summary for GRID2IP Gene

  • Glutamate receptor delta-2 (GRID2; MIM 602368) is predominantly expressed at parallel fiber-Purkinje cell postsynapses and plays crucial roles in synaptogenesis and synaptic plasticity. GRID2IP1 interacts with GRID2 and may control GRID2 signaling in Purkinje cells (Matsuda et al., 2006 [PubMed 16835239]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GRID2IP Gene

GRID2IP (Grid2 Interacting Protein) is a Protein Coding gene. An important paralog of this gene is FMNL2.

UniProtKB/Swiss-Prot for GRID2IP Gene

  • Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRID2IP Gene

Genomics for GRID2IP Gene

Regulatory Elements for GRID2IP Gene

Enhancers for GRID2IP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GRID2IP on UCSC Golden Path with GeneCards custom track

Genomic Location for GRID2IP Gene

6,496,778 bp from pter
6,551,436 bp from pter
54,659 bases
Minus strand

Genomic View for GRID2IP Gene

Genes around GRID2IP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRID2IP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRID2IP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRID2IP Gene

Proteins for GRID2IP Gene

  • Protein details for GRID2IP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for GRID2IP Gene

    1211 amino acids
    Molecular mass:
    132276 Da
    Quaternary structure:
    • Interacts with C-terminus of the glutamate receptor GRID2 via PDZ domain.
    • Sequence=EAL23724.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for GRID2IP Gene

Proteomics data for GRID2IP Gene at MOPED

Post-translational modifications for GRID2IP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GRID2IP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRID2IP Gene

Domains & Families for GRID2IP Gene

Gene Families for GRID2IP Gene

Protein Domains for GRID2IP Gene


Suggested Antigen Peptide Sequences for GRID2IP Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 FH2 (formin homology 2) domain.
  • Contains 1 FH2 (formin homology 2) domain.
  • Contains 2 PDZ (DHR) domains.
genes like me logo Genes that share domains with GRID2IP: view

Function for GRID2IP Gene

Molecular function for GRID2IP Gene

UniProtKB/Swiss-Prot Function:
Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.

Phenotypes for GRID2IP Gene

genes like me logo Genes that share phenotypes with GRID2IP: view

Animal Models for GRID2IP Gene

MGI Knock Outs for GRID2IP:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRID2IP Gene

Localization for GRID2IP Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRID2IP Gene

Cell junction, synapse, postsynaptic cell membrane.

Subcellular locations from

Jensen Localization Image for GRID2IP Gene COMPARTMENTS Subcellular localization image for GRID2IP gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for GRID2IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030054 cell junction IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with GRID2IP: view

Pathways & Interactions for GRID2IP Gene

SuperPathways for GRID2IP Gene

No Data Available

Gene Ontology (GO) - Biological Process for GRID2IP Gene


No data available for Pathways by source and SIGNOR curated interactions for GRID2IP Gene

Drugs & Compounds for GRID2IP Gene

No Compound Related Data Available

Transcripts for GRID2IP Gene

mRNA/cDNA for GRID2IP Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRID2IP Gene

Glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRID2IP Gene

No ASD Table

Relevant External Links for GRID2IP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRID2IP Gene

mRNA expression in normal human tissues for GRID2IP Gene

mRNA differential expression in normal tissues according to GTEx for GRID2IP Gene

This gene is overexpressed in Brain - Cerebellum (x7.4).

Protein differential expression in normal tissues from HIPED for GRID2IP Gene

This gene is overexpressed in Bone marrow stromal cell (37.3) and Serum (28.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRID2IP Gene

SOURCE GeneReport for Unigene cluster for GRID2IP Gene Hs.512174

genes like me logo Genes that share expression patterns with GRID2IP: view

Protein tissue co-expression partners for GRID2IP Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GRID2IP Gene

Orthologs for GRID2IP Gene

This gene was present in the common ancestor of animals.

Orthologs for GRID2IP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GRID2IP 35
  • 89.29 (n)
  • 91.87 (a)
  • 91 (a)
(Canis familiaris)
Mammalia GRID2IP 35
  • 89.49 (n)
  • 92.78 (a)
  • 93 (a)
(Mus musculus)
Mammalia Grid2ip 35
  • 85.98 (n)
  • 91.49 (a)
Grid2ip 16
Grid2ip 36
  • 91 (a)
(Pan troglodytes)
Mammalia GRID2IP 35
  • 99.37 (n)
  • 99.42 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Grid2ip 35
  • 87.16 (n)
  • 93.2 (a)
(Monodelphis domestica)
Mammalia GRID2IP 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
-- 36
  • 81 (a)
-- 36
  • 71 (a)
(Gallus gallus)
Aves GRID2IP 35
  • 71.82 (n)
  • 71.49 (a)
  • 70 (a)
(Anolis carolinensis)
Reptilia GRID2IP 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia grid2ip 35
  • 63.55 (n)
  • 63.16 (a)
(Danio rerio)
Actinopterygii LOC561017 35
  • 61.47 (n)
  • 61.35 (a)
grid2ipa 36
  • 41 (a)
grid2ipb 36
  • 50 (a)
(Caenorhabditis elegans)
Secernentea exc-6 36
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9833 36
  • 31 (a)
Species with no ortholog for GRID2IP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRID2IP Gene

Gene Tree for GRID2IP (if available)
Gene Tree for GRID2IP (if available)

Paralogs for GRID2IP Gene

Paralogs for GRID2IP Gene

(1) SIMAP similar genes for GRID2IP Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GRID2IP: view

Variants for GRID2IP Gene

Sequence variations from dbSNP and Humsavar for GRID2IP Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs11761490 - 6,551,378(+) CTAGC(C/T)GGAAG reference, missense
rs940241 -- 6,528,779(-) GGAGC(A/G)GAGCT intron-variant
rs940242 -- 6,528,678(-) ACCCA(C/T)AGAGG intron-variant
rs940245 -- 6,539,392(-) CCACG(C/T)GCTTT intron-variant
rs952042 -- 6,547,895(+) TGCAA(C/T)AGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRID2IP Gene

Variant ID Type Subtype PubMed ID
nsv436904 CNV Insertion 17901297
nsv7392 OTHER Inversion 18451855
esv1914954 OTHER Inversion 16254605
nsv830895 CNV Loss 17160897
dgv7147n71 CNV Loss 21882294
nsv508444 CNV Loss 20534489
nsv515978 CNV Loss 19592680
dgv7148n71 CNV Loss 21882294

Variation tolerance for GRID2IP Gene

Gene Damage Index Score: 12.78; 94.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GRID2IP Gene

Disorders for GRID2IP Gene

Relevant External Links for GRID2IP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GRID2IP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRID2IP Gene

Publications for GRID2IP Gene

  1. Identification and characterization of human GRID2IP gene and rat Grid2ip gene in silico. (PMID: 14612983) Katoh M. … Katoh M. (Int. J. Mol. Med. 2003) 2 3 4 67
  2. Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts. (PMID: 25248455) Ek W.E. … D'Amato M. (Gut 2015) 3
  3. Characterization of the delta2 glutamate receptor-binding protein delphilin: splicing variants with differential palmitoylation and an additional PDZ domain. (PMID: 16835239) Matsuda K. … Yuzaki M. (J. Biol. Chem. 2006) 3
  4. Binding of glutamate receptor delta2 to its scaffold protein, Delphilin, is regulated by PKA. (PMID: 17027646) Sonoda T. … Kawamoto S. (Biochem. Biophys. Res. Commun. 2006) 3
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3

Products for GRID2IP Gene

Sources for GRID2IP Gene