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GRID2 Gene

protein-coding   GIFtS: 64
GCID: GC04P093225

Glutamate Receptor, Ionotropic, Delta 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutamate Receptor, Ionotropic, Delta 21 2     Glutamate Receptor Delta-2 Subunit2
GluR Delta-2 Subunit2 3     Glutamate Receptor Ionotropic, Delta-22
GluD22 3     GLURD23
GluR-delta-22     

External Ids:    HGNC: 45761   Entrez Gene: 28952   Ensembl: ENSG000001522087   OMIM: 6023685   UniProtKB: O434243   

Export aliases for GRID2 gene to outside databases

Previous GC identifers: GC04P093383 GC04P093527 GC04P093684 GC04P093582 GC04P088967


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GRID2 Gene:
The protein encoded by this gene is a relatively new member of the family of ionotropic glutamate receptors which
are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a
predicted 1,007 amino acid protein that shares 97% identity with the mouse homolog which is expressed selectively
in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named
'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of
cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth
from massive loss of mid- and hindbrain neurons during late embryogenesis. This strongly suggests a role for this
gene in neuronal apoptotic death. Two transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Nov 2013)

GeneCards Summary for GRID2 Gene:
GRID2 (glutamate receptor, ionotropic, delta 2) is a protein-coding gene. Diseases associated with GRID2 include autosomal recessive congenital cerebellar ataxia due to grid2 deficiency, and ataxia. GO annotations related to this gene include extracellular-glutamate-gated ion channel activity and PDZ domain binding. An important paralog of this gene is GRIA3.

UniProtKB/Swiss-Prot: GRID2_HUMAN, O43424
Function: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the
central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named
according to their selective agonists

Gene Wiki entry for GRID2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GRID2 gene promoter:
         TBP   USF1   Nkx2-5   C/EBPalpha   S8   POU2F1   USF-1   POU2F1a   Pax-4a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRID2 promoter sequence
   Search Chromatin IP Primers for GRID2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRID2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q22

GRID2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRID2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P093225:  view genomic region     (about GC identifiers)

Start:
93,225,550 bp from pter      End:
94,695,707 bp from pter
Size:
1,470,158 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GRID2_HUMAN, O43424 (See protein sequence)
Recommended Name: Glutamate receptor ionotropic, delta-2 precursor  
Size: 1007 amino acids; 113356 Da
Subunit: Interacts with AIP1, AP4M1, BECN1, GOPC, GRID2IP, SHANK1 and SHANK2 (By similarity). Interacts with CBLN1
and CBLN2, but not with CBLN4. CBLN1-binding is calcium-independent (By similarity)
Sequence caution: Sequence=BAD92555.1; Type=Erroneous initiation;
Secondary accessions: Q4KKU9 Q4KKV0 Q59FZ1

Explore the universe of human proteins at neXtProt for GRID2: NX_O43424

Explore proteomics data for GRID2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn293, Asn426
  • Modification sites at PhosphoSitePlus

  • See GRID2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273767.1  NP_001501.2  

    ENSEMBL proteins: 
     ENSP00000282020   ENSP00000421257   ENSP00000422845   ENSP00000423331   ENSP00000425794  

    GRID2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GRI: Ligand-gated ion channels / Glutamate receptors, ionotropic
    GR: Glutamate receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GluD2
    Ionotropic glutamate receptors

    Selected InterPro protein domains (see all 6):
     IPR028082 Peripla_BP_I
     IPR019594 Glu_rcpt_Glu/Gly-bd
     IPR001638 SBP_bac_3
     IPR001320 Iontro_glu_rcpt
     IPR001828 ANF_lig-bd_rcpt

    Graphical View of Domain Structure for InterPro Entry O43424

    ProtoNet protein and cluster: O43424

    3 Blocks protein domains:
    IPB001320 Ionotropic glutamate receptor
    IPB001508 NMDA receptor signature
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GRID2_HUMAN, O43424
    Domain: The PDZ-binding motif mediates interaction with GOPC (By similarity)
    Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID2 subfamily


    GRID2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRID2_HUMAN, O43424
    Function: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the
    central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named
    according to their selective agonists

         Genatlas biochemistry entry for GRID2:
    glutamate receptor,ionotropic,delta 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004970ionotropic glutamate receptor activity IBA--
    GO:0005215transporter activity ----
    GO:0005234extracellular-glutamate-gated ion channel activity IBA--
    GO:0005515protein binding ----
    GO:0008066glutamate receptor activity TAS9465309
         
    GRID2 for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 27 alleles(MGI details for Grid2):
     behavior/neurological  cellular  growth/size/body  hearing/vestibular/ear  homeostasis/metabolism 
     mortality/aging  muscle  nervous system  no phenotypic analysis  reproductive system 
     vision/eye 

    GRID2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GRID2: Grid2tm1Mim Grid2tm2Msmh

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRID2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GRID2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRID2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GRID2

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    Predesigned siRNA for gene silencing in human, mouse, rat GRID2

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    Sino Biological Human cDNA Clone for GRID2
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRID2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GRID2_HUMAN, O43424: Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse,
    postsynaptic cell membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ISS--
    GO:0005887integral component of plasma membrane TAS9465309
    GO:0008328ionotropic glutamate receptor complex ISS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    GRID2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GRID2 About    
    See pathways by source

    SuperPathContained pathways About
    1CREB Pathway
    CREB Pathway0.68
    Intracellular Calcium Signaling0.50
    2Peptide ligand-binding receptors
    Neuroactive ligand-receptor interaction0.36
    3Long-term depression
    Long-term depression
    4Glutamic acid signaling
    Glutamic acid signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GRID2
        CREB Pathway
    Intracellular Calcium Signaling



    2 Kegg Pathways  (Kegg details for GRID2):
        Neuroactive ligand-receptor interaction
    Long-term depression


    GRID2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GRID2
    Interactions:

        GeneGlobe Interaction Network for GRID2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GRID2 (O434242, 3 ENSP000002820204) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRIA2P422623, ENSP000002644264I2D: score=2 STRING: ENSP00000264426
    DLG1Q129593, ENSP000003457314I2D: score=1 STRING: ENSP00000345731
    MAGI2Q86UL83, ENSP000003461514I2D: score=1 STRING: ENSP00000346151
    AP4M1O001893, ENSP000003526034I2D: score=1 STRING: ENSP00000352603
    DLG2Q157003, ENSP000003652724I2D: score=2 STRING: ENSP00000365272
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS9465309
    GO:0007157heterophilic cell-cell adhesion ISS--
    GO:0007215glutamate receptor signaling pathway TAS9465309
    GO:0010975regulation of neuron projection development IEA--
    GO:0021707cerebellar granule cell differentiation ISS--

    GRID2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GRID2

    1 DrugBank Compound for GRID2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--17139284 17016423

    3 Novoseek inferred chemical compound relationships for GRID2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 67.7 28 12573530 (5), 9465309 (2), 15728855 (1), 17027646 (1) (see all 13)
    kainate 42.9 3 10934245 (1), 19176800 (1), 12573530 (1)
    steroid 15.2 1 18263760 (1)



    GRID2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GRID2 gene (2 alternative transcripts): 
    NM_001286838.1  NM_001510.3  

    Unigene Cluster for GRID2:

    Glutamate receptor, ionotropic, delta 2
    Hs.480281  [show with all ESTs]
    Unigene Representative Sequence: AB209318
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282020(uc011cdt.2 uc011cdu.2) ENST00000505687(uc010ikx.3)
    ENST00000510992 ENST00000515744 ENST00000502699(uc011cdv.1) ENST00000512631(uc010ikz.1)
    ENST00000513976

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    Additional mRNA sequence: 

    AB209318.1 AF009014.1 AK302355.1 AK308611.1 AK310262.1 BC099652.3 BC099653.3 BC099654.3 

    2 DOTS entries:

    DT.91653326  DT.121256675 

    2 AceView cDNA sequences:

    NM_001510 AF009014 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for GRID2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:                                                                                                            
    SP2:                    -                                                                                       


    ECgene alternative splicing isoforms for GRID2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GRID2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTCCCAAA
    GRID2 Expression
    About this image


    GRID2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neurons
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Brain (Nervous System)
             Cerebellum
    GRID2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GRID2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.480281
        Custom PCR Arrays for GRID2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRID2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GRID2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grid21 , 5 glutamate receptor, ionotropic, delta 21, 5 90.2(n)1
    97.62(a)1
      6 (29.77 cM)5
    148041  NM_008167.21  NP_032193.11 
     632558765 
    chicken
    (Gallus gallus)
    Aves GRID21 glutamate receptor, ionotropic, delta 2 84.18(n)
    94.24(a)
      422520  XM_420483.4  XP_420483.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    96(a)
    94(a)
    1 ↔ many
    1 ↔ many
    5(48625325-48634732)
    5(48411108-48491109)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia grid21 glutamate receptor, ionotropic, delta 2 79.08(n)
    89.97(a)
      100487676  XM_002937235.2  XP_002937281.2 
    zebrafish
    (Danio rerio)
    Actinopterygii grid21 glutamate receptor, ionotropic, delta 2 72.36(n)
    82.03(a)
      448841  NM_001004123.1  NP_001004123.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG156273 glutamate-gated ion channel 28(a)   25A8   --
    worm
    (Caenorhabditis elegans)
    Secernentea glr-46
    Protein GLR-4, isoform b (glr-4) mRNA, complete cd...
    24(a)
    many ↔ many
    II(7785074-7794319) WBGene00001615


    ENSEMBL Gene Tree for GRID2 (if available)
    TreeFam Gene Tree for GRID2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GRID2 gene
    GRIA32  GRIK52  GRIK12  GRIA22  GRIA42  GRIK22  GRID12  GRIA12  
    GRIK32  GRIK42  
    12 SIMAP similar genes for GRID2 using alignment to 10 protein entries:     GRID2_HUMAN (see all proteins):
    GRID1    GRIN2C    GRIN2A    GRIK2    GRIA1    GRIK4
    GRIK3    GRIN1    GRIK1    GRIA2    GRIA4    GRIA3

    GRID2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GRID2 (see all 28031)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356974
    A colorectal cancer sample4--see VAR_0356972 T N mis40--------
    rs1863397841,2
    Cuntested193375759(+) GAGATA/C/TGGCAG 1 -- int10--------
    rs2020144371,2
    Cuntested194690582(+) AGGCTC/G/TCCGGG 2 S F mis10--------
    rs712175621,2
    C--89137976(+) TTTTTT/GGGGGG 1 -- int12Minor allele frequency- G:0.25NA 4
    rs126429771,2
    C,H--89200747(+) TGCGgG/Tgtgtg 1 -- int10--------
    rs665130741,2
    C--93122799(+) AGCAG-/CT    
       
    /CTCT
    CTCTC
    1 -- int11NA 2
    rs1500790031,2
    --93224058(+) GACCTC/TGACTA 1 -- us2k10--------
    rs1407427211,2
    C--93224477(+) GACAG-/AAAAAA 1 -- us2k10--------
    rs2012991651,2
    --93224728(+) AAAGG-/AAAAAA 1 -- us2k10--------
    rs1414341981,2
    --93224732(+) GGAAAA/GAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GRID2 (93225550 - 93475550 bp, first 250kb of GRID2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GRID2 (see all 86):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2727989CNV Deletion23290073
    esv2677473CNV Deletion23128226
    esv2727982CNV Deletion23290073
    esv2663113CNV Deletion23128226
    esv2666919CNV Deletion23128226
    esv2727983CNV Deletion23290073
    dgv963e199CNV Deletion23128226
    esv2659413CNV Deletion23128226
    esv2592799CNV Deletion19546169
    dgv962e199CNV Deletion23128226

    Human Gene Mutation Database (HGMD): GRID2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GRID2
    DNA2.0 Custom Variant and Variant Library Synthesis for GRID2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602368    OMIM disorders: --

    10 diseases for GRID2:    
    About MalaCards
    autosomal recessive congenital cerebellar ataxia due to grid2 deficiency    ataxia    chronic fatigue syndrome    spinocerebellar ataxia
    cleft palate    neuronitis    cleft lip    breast and colorectal cancer
    obesity    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for GRID2:
    Chronic fatigue syndrome

    GRID2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): GRID2
    Human Genome Epidemiology (HuGE) Navigator: GRID2 (3 documents)

    Export disorders for GRID2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for GRID2 gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with GRID2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human glutamate receptor delta 2 gene (GRID2) maps to chromosome 4q22. (PubMed id 9465309)1, 2, 3, 9 Hu W.... Heintz N. (Genomics 1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors. (PubMed id 12573530)1, 9 Kohda K....Yuzaki M. (Brain Res. Mol. Brain Res. 2003)
    4. Binding of glutamate receptor delta2 to its scaffold protein, Delphilin, is regulated by PKA. (PubMed id 17027646)1, 9 Sonoda T....Kawamoto S. (Biochem. Biophys. Res. Commun. 2006)
    5. Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study. (PubMed id 23512105)1 Beaty T.H....Ruczinski I. (Hum. Genet. 2013)
    6. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    7. Glutamate receptor I'2 is essential for input pathway-dependent regulation of synaptic AMPAR contents in cerebellar Purkinje cells. (PubMed id 21368048)1 Yamasaki M....Watanabe M. (J. Neurosci. 2011)
    8. Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol. (PubMed id 20859245)1 Giegling I....Serretti A. (Pharmacogenet. Genomics 2011)
    9. A whole genome association study of mother-to-child transmission of HIV in Malawi. (PubMed id 20487506)1 Joubert B.R....Meshnick S.R. (Genome Med 2010)
    10. Differential regulation of synaptic plasticity and cerebellar motor learning by the C-terminal PDZ-binding motif of GluRdelta2. (PubMed id 18256267)1 Kakegawa W....Yuzaki M. (J. Neurosci. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 2895 HGNC: 4576 AceView: GRID2.1 Ensembl:ENSG00000152208 euGenes: HUgn2895
    ECgene: GRID2 Kegg: 2895 H-InvDB: GRID2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GRID2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GRID2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GRID2 gene:
    Search GeneIP for patents involving GRID2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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