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Aliases for GRID1 Gene

Aliases for GRID1 Gene

  • Glutamate Receptor, Ionotropic, Delta 1 2 3
  • GluR Delta-1 Subunit 3 4
  • KIAA1220 4 6
  • GluD1 3 4
  • Glutamate Receptor Ionotropic, Delta-1 3
  • Glutamate Receptor Delta-1 Subunit 3

External Ids for GRID1 Gene

Summaries for GRID1 Gene

Entrez Gene Summary for GRID1 Gene

  • This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[provided by RefSeq, Jan 2009]

GeneCards Summary for GRID1 Gene

GRID1 (Glutamate Receptor, Ionotropic, Delta 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include extracellular-glutamate-gated ion channel activity and ionotropic glutamate receptor activity. An important paralog of this gene is GRID2.

UniProtKB/Swiss-Prot for GRID1 Gene

  • Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists

Gene Wiki entry for GRID1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRID1 Gene

Genomics for GRID1 Gene

Genomic Location for GRID1 Gene

Start:
85,599,555 bp from pter
End:
86,366,493 bp from pter
Size:
766,939 bases
Orientation:
Minus strand

Genomic View for GRID1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRID1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRID1 Gene

Regulatory Elements for GRID1 Gene

Proteins for GRID1 Gene

  • Protein details for GRID1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULK0-GRID1_HUMAN
    Recommended name:
    Glutamate receptor ionotropic, delta-1
    Protein Accession:
    Q9ULK0
    Secondary Accessions:
    • B3KXD5
    • B7Z7L0
    • Q8IXT3

    Protein attributes for GRID1 Gene

    Size:
    1009 amino acids
    Molecular mass:
    112131 Da
    Quaternary structure:
    • Interacts with CBLN1, and more weakly with CBLN2.

    Alternative splice isoforms for GRID1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRID1 Gene

Proteomics data for GRID1 Gene at MOPED

Post-translational modifications for GRID1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn200, Asn422, and Asn498

Other Protein References for GRID1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRID1 Gene

Domains for GRID1 Gene

Gene Families for GRID1 Gene

HGNC:
  • GRI :Ligand-gated ion channels / Glutamate receptors, ionotropic
  • GR :Glutamate receptors
IUPHAR :

UniProtKB/Swiss-Prot:

GRID1_HUMAN
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID1 subfamily.:
    • Q9ULK0
genes like me logo Genes that share domains with GRID1: view

Function for GRID1 Gene

Molecular function for GRID1 Gene

UniProtKB/Swiss-Prot Function: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists

Gene Ontology (GO) - Molecular Function for GRID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004970 ionotropic glutamate receptor activity IBA --
GO:0005234 extracellular-glutamate-gated ion channel activity IBA --
genes like me logo Genes that share ontologies with GRID1: view
genes like me logo Genes that share phenotypes with GRID1: view

Animal Models for GRID1 Gene

MGI Knock Outs for GRID1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GRID1 Gene

Localization for GRID1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRID1 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRID1 Gene COMPARTMENTS Subcellular localization image for GRID1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GRID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008328 ionotropic glutamate receptor complex IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0030054 cell junction IEA --
GO:0030425 dendrite IBA --
genes like me logo Genes that share ontologies with GRID1: view

Pathways for GRID1 Gene

genes like me logo Genes that share pathways with GRID1: view

Pathways by source for GRID1 Gene

1 KEGG pathway for GRID1 Gene

Gene Ontology (GO) - Biological Process for GRID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034220 ion transmembrane transport IBA --
GO:0035176 social behavior ISS --
GO:0035235 ionotropic glutamate receptor signaling pathway IBA --
GO:0035249 synaptic transmission, glutamatergic IBA --
genes like me logo Genes that share ontologies with GRID1: view

Compounds for GRID1 Gene

(1) Drugbank Compounds for GRID1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target
genes like me logo Genes that share compounds with GRID1: view

Transcripts for GRID1 Gene

Unigene Clusters for GRID1 Gene

Glutamate receptor, ionotropic, delta 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRID1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP2: - -
SP3:

Relevant External Links for GRID1 Gene

GeneLoc Exon Structure for
GRID1
ECgene alternative splicing isoforms for
GRID1

Expression for GRID1 Gene

mRNA expression in normal human tissues for GRID1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GRID1 Gene

SOURCE GeneReport for Unigene cluster for GRID1 Gene Hs.530653

genes like me logo Genes that share expressions with GRID1: view

Orthologs for GRID1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRID1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRID1 37
  • 100 (a)
OneToOne
LOC100612556 36
  • 99.35 (n)
  • 99.48 (a)
cow
(Bos Taurus)
Mammalia GRID1 36
  • 92.24 (n)
  • 99.19 (a)
GRID1 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRID1 36
  • 92.5 (n)
  • 98.88 (a)
GRID1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grid1 36
  • 91.15 (n)
  • 98.41 (a)
Grid1 16
Grid1 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRID1 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRID1 37
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRID1 36
  • 79.45 (n)
  • 89.69 (a)
GRID1 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRID1 37
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grid1 36
  • 73.45 (n)
  • 85.02 (a)
zebrafish
(Danio rerio)
Actinopterygii grid1a 37
  • 74 (a)
OneToMany
grid1b 36
  • 73.83 (n)
  • 79.8 (a)
grid1b 37
  • 70 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Glu-RI 37
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea glr-2 37
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 46 (a)
OneToMany
Species with no ortholog for GRID1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRID1 Gene

ENSEMBL:
Gene Tree for GRID1 (if available)
TreeFam:
Gene Tree for GRID1 (if available)

Paralogs for GRID1 Gene

Paralogs for GRID1 Gene

Selected SIMAP similar genes for GRID1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GRID1: view

Variants for GRID1 Gene

Sequence variations from dbSNP and Humsavar for GRID1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs25434 -- 85,913,014(+) ATAGC(C/T)GGATC intron-variant
rs25435 -- 85,913,036(+) CCTAC(G/T)TGTAA intron-variant
rs186473 -- 85,841,255(-) ccatt(C/T)attaa intron-variant
rs724862 -- 86,340,785(-) GCTCT(C/G)CTCCC intron-variant
rs733758 -- 85,652,368(+) ACTTG(C/T)AACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRID1 Gene

Variant ID Type Subtype PubMed ID
esv2676888 CNV Deletion 23128226
esv999303 CNV Loss 20482838
esv274544 CNV Insertion 20981092
nsv522357 CNV Loss 19592680
nsv519532 CNV Loss 19592680
nsv831935 CNV Gain 17160897
esv2666181 CNV Deletion 23128226
esv2739162 CNV Deletion 23290073
esv2739173 CNV Deletion 23290073
esv2671815 CNV Deletion 23128226
esv24557 CNV Loss 19812545
nsv442200 CNV CNV 18776908
nsv831936 CNV Loss 17160897
esv2657402 CNV Deletion 23128226
esv2592801 CNV Insertion 19546169
esv1111287 CNV Insertion 17803354
nsv525816 CNV Loss 19592680
nsv7477 CNV Insertion 18451855
esv2670315 CNV Deletion 23128226
esv29595 CNV Loss 19812545
nsv515541 CNV Loss 19592680
esv2666548 CNV Deletion 23128226
esv270835 CNV Insertion 20981092
esv272870 CNV Insertion 20981092
nsv831938 CNV Gain 17160897
nsv520914 CNV Loss 19592680
nsv525817 CNV Loss 19592680
esv28516 CNV Loss 19812545

Relevant External Links for GRID1 Gene

HapMap Linkage Disequilibrium report
GRID1
Human Gene Mutation Database (HGMD)
GRID1

Disorders for GRID1 Gene

(1) University of Copenhagen DISEASES for GRID1 Gene

Relevant External Links for GRID1

Genetic Association Database (GAD)
GRID1
Human Genome Epidemiology (HuGE) Navigator
GRID1
genes like me logo Genes that share disorders with GRID1: view

No data available for UniProtKB/Swiss-Prot for GRID1 Gene

Publications for GRID1 Gene

  1. Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoter. (PMID: 19346103) Treutlein J. … Rietschel M. (Schizophr. Res. 2009) 3 23 49
  2. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  3. Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. (PMID: 19584346) Vasan R.S. … Blankenberg S. (JAMA 2009) 3 49
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for GRID1 Gene

Sources for GRID1 Gene

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