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Aliases for GRID1 Gene

Aliases for GRID1 Gene

  • Glutamate Receptor, Ionotropic, Delta 1 2 3
  • GluR Delta-1 Subunit 3 4
  • GluD1 3 4
  • Glutamate Receptor Delta-1 Subunit 3
  • KIAA1220 4

External Ids for GRID1 Gene

Previous GeneCards Identifiers for GRID1 Gene

  • GC10M086316
  • GC10M086581
  • GC10M087490
  • GC10M087023
  • GC10M087349
  • GC10M081205

Summaries for GRID1 Gene

Entrez Gene Summary for GRID1 Gene

  • This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[provided by RefSeq, Jan 2009]

GeneCards Summary for GRID1 Gene

GRID1 (Glutamate Receptor, Ionotropic, Delta 1) is a Protein Coding gene. Diseases associated with GRID1 include bipolar i disorder and schizophrenia. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include ionotropic glutamate receptor activity and extracellular-glutamate-gated ion channel activity. An important paralog of this gene is GRID2.

UniProtKB/Swiss-Prot for GRID1 Gene

  • Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists

Gene Wiki entry for GRID1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRID1 Gene

Genomics for GRID1 Gene

Regulatory Elements for GRID1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GRID1 Gene

Chromosome:
10
Start:
85,599,555 bp from pter
End:
86,366,493 bp from pter
Size:
766,939 bases
Orientation:
Minus strand

Genomic View for GRID1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRID1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRID1 Gene

Proteins for GRID1 Gene

  • Protein details for GRID1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULK0-GRID1_HUMAN
    Recommended name:
    Glutamate receptor ionotropic, delta-1
    Protein Accession:
    Q9ULK0
    Secondary Accessions:
    • B3KXD5
    • B7Z7L0
    • Q8IXT3

    Protein attributes for GRID1 Gene

    Size:
    1009 amino acids
    Molecular mass:
    112131 Da
    Quaternary structure:
    • Interacts with CBLN1, and more weakly with CBLN2.

    Alternative splice isoforms for GRID1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRID1 Gene

Proteomics data for GRID1 Gene at MOPED

Post-translational modifications for GRID1 Gene

  • Glycosylation at Asn 200, Asn 422, and Asn 498
  • Modification sites at PhosphoSitePlus

Other Protein References for GRID1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GRID1 Gene

Domains & Families for GRID1 Gene

Gene Families for GRID1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULK0

UniProtKB/Swiss-Prot:

GRID1_HUMAN :
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID1 subfamily.
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID1 subfamily.
genes like me logo Genes that share domains with GRID1: view

Function for GRID1 Gene

Molecular function for GRID1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists

Gene Ontology (GO) - Molecular Function for GRID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004970 ionotropic glutamate receptor activity IBA --
GO:0005234 extracellular-glutamate-gated ion channel activity IBA --
genes like me logo Genes that share ontologies with GRID1: view
genes like me logo Genes that share phenotypes with GRID1: view

Animal Models for GRID1 Gene

MGI Knock Outs for GRID1:

Animal Model Products

miRNA for GRID1 Gene

miRTarBase miRNAs that target GRID1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRID1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GRID1 Gene

Localization for GRID1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRID1 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRID1 Gene COMPARTMENTS Subcellular localization image for GRID1 gene
Compartment Confidence
extracellular 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for GRID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0008328 ionotropic glutamate receptor complex IBA --
GO:0016020 membrane --
GO:0030054 cell junction IEA --
GO:0030425 dendrite IBA --
genes like me logo Genes that share ontologies with GRID1: view

Pathways & Interactions for GRID1 Gene

genes like me logo Genes that share pathways with GRID1: view

Pathways by source for GRID1 Gene

1 KEGG pathway for GRID1 Gene

Gene Ontology (GO) - Biological Process for GRID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034220 ion transmembrane transport IBA --
GO:0035176 social behavior ISS --
GO:0035235 ionotropic glutamate receptor signaling pathway IBA --
GO:0035249 synaptic transmission, glutamatergic IBA --
genes like me logo Genes that share ontologies with GRID1: view

No data available for SIGNOR curated interactions for GRID1 Gene

Drugs & Compounds for GRID1 Gene

(9) Drugs for GRID1 Gene - From: ApexBio and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Glutamic Acid Nutra Full agonist, Agonist, Target 0
ADX-47273 Pharma 0
IEM 1754 dihydrobroMide Pharma 0
Ifenprodil Tartrate Pharma NMDA receptor antagonist 0
Latrepirdine Pharma Brain cell death inhibitor 0
genes like me logo Genes that share compounds with GRID1: view

Transcripts for GRID1 Gene

Unigene Clusters for GRID1 Gene

Glutamate receptor, ionotropic, delta 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRID1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRID1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP2: - -
SP3:

Relevant External Links for GRID1 Gene

GeneLoc Exon Structure for
GRID1
ECgene alternative splicing isoforms for
GRID1

Expression for GRID1 Gene

mRNA expression in normal human tissues for GRID1 Gene

Protein differential expression in normal tissues from HIPED for GRID1 Gene

This gene is overexpressed in CD4 Tcells (24.8), Frontal cortex (24.5), Fetal Brain (8.3), and Adipocyte (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GRID1 Gene



SOURCE GeneReport for Unigene cluster for GRID1 Gene Hs.530653

genes like me logo Genes that share expression patterns with GRID1: view

Protein tissue co-expression partners for GRID1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GRID1 Gene

Orthologs for GRID1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRID1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GRID1 35
  • 92.24 (n)
  • 99.19 (a)
GRID1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRID1 35
  • 92.5 (n)
  • 98.88 (a)
GRID1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grid1 35
  • 91.15 (n)
  • 98.41 (a)
Grid1 16
Grid1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC100612556 35
  • 99.35 (n)
  • 99.48 (a)
GRID1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRID1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRID1 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRID1 35
  • 79.45 (n)
  • 89.69 (a)
GRID1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRID1 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grid1 35
  • 73.45 (n)
  • 85.02 (a)
zebrafish
(Danio rerio)
Actinopterygii grid1b 35
  • 73.83 (n)
  • 79.8 (a)
grid1a 36
  • 74 (a)
OneToMany
grid1b 36
  • 70 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Glu-RI 36
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea glr-2 36
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for GRID1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRID1 Gene

ENSEMBL:
Gene Tree for GRID1 (if available)
TreeFam:
Gene Tree for GRID1 (if available)

Paralogs for GRID1 Gene

Paralogs for GRID1 Gene

(7) SIMAP similar genes for GRID1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GRID1: view

Variants for GRID1 Gene

Sequence variations from dbSNP and Humsavar for GRID1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs867820 -- 86,288,454(+) TTTTA(G/T)GAAGC intron-variant
rs867821 -- 86,288,502(+) TTCAG(C/T)AACTT intron-variant
rs868042 -- 86,164,198(+) AGCAC(A/T)AAAAT intron-variant
rs871709 -- 86,289,256(-) CTTGG(A/G)GCCCT intron-variant
rs872813 -- 86,223,489(+) CTCTG(C/T)GCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRID1 Gene

Variant ID Type Subtype PubMed ID
esv2676888 CNV Deletion 23128226
esv999303 CNV Loss 20482838
esv274544 CNV Insertion 20981092
nsv522357 CNV Loss 19592680
nsv519532 CNV Loss 19592680
nsv831935 CNV Gain 17160897
esv2666181 CNV Deletion 23128226
esv2739162 CNV Deletion 23290073
esv2739173 CNV Deletion 23290073
esv2671815 CNV Deletion 23128226
esv24557 CNV Loss 19812545
nsv442200 CNV CNV 18776908
nsv831936 CNV Loss 17160897
esv2657402 CNV Deletion 23128226
esv2592801 CNV Insertion 19546169
esv1111287 CNV Insertion 17803354
nsv525816 CNV Loss 19592680
nsv7477 CNV Insertion 18451855
esv2670315 CNV Deletion 23128226
esv29595 CNV Loss 19812545
nsv515541 CNV Loss 19592680
esv2666548 CNV Deletion 23128226
esv270835 CNV Insertion 20981092
esv272870 CNV Insertion 20981092
nsv831938 CNV Gain 17160897
nsv520914 CNV Loss 19592680
nsv525817 CNV Loss 19592680
esv28516 CNV Loss 19812545

Variation tolerance for GRID1 Gene

Residual Variation Intolerance Score: 2.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.27; 70.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRID1 Gene

HapMap Linkage Disequilibrium report
GRID1
Human Gene Mutation Database (HGMD)
GRID1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRID1 Gene

Disorders for GRID1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GRID1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bipolar i disorder
schizophrenia
  • schizophrenia 12
- elite association
Search GRID1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GRID1

Genetic Association Database (GAD)
GRID1
Human Genome Epidemiology (HuGE) Navigator
GRID1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRID1
genes like me logo Genes that share disorders with GRID1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRID1 Gene

Publications for GRID1 Gene

  1. A MicroRNA gene is hosted in an intron of a schizophrenia-susceptibility gene. (PMID: 19264453) Zhu Y. … Li Y. (Schizophr. Res. 2009) 23 67
  2. Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoter. (PMID: 19346103) Treutlein J. … Rietschel M. (Schizophr. Res. 2009) 23 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. GluD1 is a common altered player in neuronal differentiation from both MECP2-mutated and CDKL5-mutated iPS cells. (PMID: 24916645) Livide G. … Meloni I. (Eur. J. Hum. Genet. 2015) 67
  5. Genome-wide association study of survival in patients with pancreatic adenocarcinoma. (PMID: 23180869) Wu C. … Wolpin B.M. (Gut 2014) 67

Products for GRID1 Gene

Sources for GRID1 Gene

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