Aliases for GRID1 Gene
Aliases for GRID1 Gene
External Ids for GRID1 Gene
- HGNC: 4575
- Entrez Gene: 2894
- Ensembl: ENSG00000182771
- OMIM: 610659
- UniProtKB: Q9ULK0
Previous GeneCards Identifiers for GRID1 Gene
- GC10M086316
- GC10M086581
- GC10M087490
- GC10M087023
- GC10M087349
- GC10M081205
Summaries for GRID1 Gene
-
This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[provided by RefSeq, Jan 2009]
GeneCards Summary for GRID1 Gene
GRID1 (Glutamate Ionotropic Receptor Delta Type Subunit 1) is a Protein Coding gene. Diseases associated with GRID1 include Bipolar I Disorder and Rett Syndrome. Among its related pathways are Peptide ligand-binding receptors and MECP2 and Associated Rett Syndrome. Gene Ontology (GO) annotations related to this gene include ionotropic glutamate receptor activity and extracellularly glutamate-gated ion channel activity. An important paralog of this gene is GRID2.
UniProtKB/Swiss-Prot for GRID1 Gene
-
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.
Additional gene information for GRID1 Gene
- Monarch Initiative
- Search for GRID1 at DataMed
- Search for GRID1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRID1 Gene
Genomics for GRID1 Gene
GeneHancer (GH) Regulatory Elements for GRID1 Gene
Promoters and enhancers for GRID1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH10I086366 | Promoter/Enhancer | 1.6 | EPDnew Ensembl dbSUPER | 550.8 | -0.2 | -208 | 0.6 | MXI1 USF1 ZNF777 ZBTB6 L3MBTL2 USF2 ZNF398 POLR2A PATZ1 ZNF341 | GRID1 GC10M086380 | |
| GH10I086399 | Enhancer | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 17.1 | -34.9 | -34910 | 3.9 | HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF213 ZNF207 | ENSG00000227896 ENSG00000272631 GRID1 WAPL LDB3 OPN4 GC10M086380 GC10P086443 | |
| GH10I086345 | Enhancer | 0.9 | ENCODE dbSUPER | 14.5 | +19.8 | 19840 | 2.2 | MXI1 MAX BRCA1 POLR2A ZNF143 RCOR1 CHD2 EZH2 TCF7L2 MAZ | GRID1 MIR346 | |
| GH10I086364 | Enhancer | 0.7 | ENCODE dbSUPER | 15.6 | +3.2 | 3164 | 0.1 | CTCF SUZ12 CTBP2 REST RAD21 EZH2 | GRID1 MIR346 | |
| GH10I086344 | Enhancer | 0.5 | dbSUPER | 21 | +21.5 | 21493 | 0.9 | CTCF RFX1 MAX ZIC2 E2F6 | GRID1 MIR346 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around GRID1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for GRID1 Gene
Genomic Locations for GRID1 Gene
- chr10:85,599,555-86,366,493
- (GRCh38/hg38)
- Size:
- 766,939 bases
- Orientation:
- Minus strand
- chr10:87,359,312-88,126,250
- (GRCh37/hg19)
Genomic View for GRID1 Gene
Genes around GRID1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q23.2 by Ensembl
- 10q23.1-q23.2 by Entrez Gene
- 10q23.1-q23.2 by HGNC
GRID1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GRID1 Gene
Proteins for GRID1 Gene
-
Protein details for GRID1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9ULK0-GRID1_HUMAN
- Recommended name:
- Glutamate receptor ionotropic, delta-1
- Protein Accession:
- Q9ULK0
- B3KXD5
- B7Z7L0
- Q8IXT3
Protein attributes for GRID1 Gene
- Size:
- 1009 amino acids
- Molecular mass:
- 112131 Da
- Quaternary structure:
-
- Dimer. Interacts (via extracellular N-terminal domain) with CBLN1 (via C1q domain), and more weakly with CBLN2.
Protein Expression for GRID1 Gene
Post-translational modifications for GRID1 Gene
- Glycosylation at posLast=200200, posLast=422422, and posLast=498498
Other Protein References for GRID1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for GRID1
- Novus Biologicals Antibodies for GRID1
-
Abcam antibodies for GRID1
- Invitrogen Antibodies for GRID1
- GeneTex GRID1 antibody for GRID1
-
Santa Cruz Biotechnology (SCBT) Antibodies for GRID1
Protein Products
-
OriGene Purified Proteins for GRID1
- Search Origene for MassSpec and Protein Over-expression Lysates for GRID1
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- Novus Biologicals proteins for GRID1
- antibodies-online: Search results for 9 available GRID1 Proteins ranked by validation data
- Compare Top GRID1 Proteins
-
Quality Products:
- Search GeneTex for Proteins for GRID1
-
Abcam proteins for GRID1
Assay Products
No data available for DME Specific Peptides for GRID1 Gene
Domains & Families for GRID1 Gene
Gene Families for GRID1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for GRID1 Gene
Suggested Antigen Peptide Sequences for GRID1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9ULK0UniProtKB/Swiss-Prot:
GRID1_HUMAN :- Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID1 subfamily.
- Family:
-
- Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID1 subfamily.
Function for GRID1 Gene
Molecular function for GRID1 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.
Phenotypes From GWAS Catalog for GRID1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004970 | ionotropic glutamate receptor activity | IEA | -- |
| GO:0005216 | ion channel activity | IEA | -- |
| GO:0005234 | extracellularly glutamate-gated ion channel activity | IEA | -- |
Phenotypes for GRID1 Gene
- MGI mutant phenotypes for GRID1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GRID1:
Animal Models for GRID1 Gene
- MGI Knock Outs for GRID1:
-
- Grid1 tm1Jnz
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for GRID1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for GRID1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GRID1 gene
- Search ViGene Biosciences for GRID1
CRISPR Products
-
OriGene CRISPR knockouts for GRID1
- genomics-online: gRNA clones - Search results for 92 available GRID1 gene related products
- Overview of 92 available GRID1 gene related products
- Applied Biological Materials CRISPR for GRID1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRID1
- GenScript: Design CRISPR guide RNA sequences for GRID1
miRNA for GRID1 Gene
- miRTarBase miRNAs that target GRID1
-
- hsa-mir-5011-5p (MIRT517498)
- hsa-mir-190a-3p (MIRT517499)
- hsa-mir-410-3p (MIRT517500)
- hsa-mir-1277-5p (MIRT517501)
- hsa-mir-6848-3p (MIRT623747)
- hsa-mir-6843-3p (MIRT623748)
- hsa-mir-6873-3p (MIRT623749)
- hsa-mir-377-3p (MIRT623750)
- hsa-mir-6895-3p (MIRT623751)
- hsa-mir-138-5p (MIRT623752)
- hsa-mir-6131 (MIRT623753)
- hsa-mir-133a-5p (MIRT623754)
- hsa-mir-3663-5p (MIRT623755)
- hsa-mir-6817-3p (MIRT623756)
- hsa-mir-7110-3p (MIRT623757)
- hsa-mir-342-3p (MIRT623758)
- hsa-mir-6722-5p (MIRT623759)
- hsa-mir-6768-5p (MIRT623760)
- hsa-mir-8485 (MIRT623761)
- hsa-mir-4709-3p (MIRT628176)
- hsa-mir-4699-5p (MIRT628177)
- hsa-mir-1238-3p (MIRT657595)
- hsa-mir-670-3p (MIRT657596)
- hsa-mir-6867-3p (MIRT657597)
- hsa-mir-6749-3p (MIRT657598)
- hsa-mir-6792-3p (MIRT657599)
- hsa-mir-4691-5p (MIRT657600)
- hsa-mir-642a-5p (MIRT657601)
- hsa-mir-6826-3p (MIRT657602)
- hsa-mir-3124-3p (MIRT657603)
- hsa-mir-4287 (MIRT657604)
- hsa-mir-4685-3p (MIRT657605)
- hsa-mir-7113-3p (MIRT657606)
- hsa-mir-4469 (MIRT657607)
- hsa-mir-6769b-3p (MIRT657608)
- hsa-mir-4723-3p (MIRT657609)
- hsa-mir-3183 (MIRT657610)
- hsa-mir-660-3p (MIRT657611)
- hsa-mir-5193 (MIRT657612)
- hsa-mir-2276-5p (MIRT657613)
- hsa-mir-6892-3p (MIRT657614)
- hsa-mir-5196-3p (MIRT657615)
- hsa-mir-4283 (MIRT710754)
- hsa-mir-4448 (MIRT710755)
- hsa-mir-423-5p (MIRT710756)
- hsa-mir-3184-5p (MIRT710757)
- hsa-mir-4530 (MIRT710758)
- hsa-mir-922 (MIRT710759)
- hsa-mir-1298-3p (MIRT710760)
- hsa-mir-3126-3p (MIRT710761)
- hsa-mir-6813-5p (MIRT710762)
- hsa-mir-6856-5p (MIRT710763)
- hsa-mir-6085 (MIRT710764)
- hsa-mir-6758-5p (MIRT710765)
miRNA Products
- Search ViGene Biosciences for GRID1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for GRID1
- Browse OriGene Inhibitory RNA Products For GRID1
- genomics-online: shRNA clones - Search results for 92 available GRID1 gene related products
- Overview of 92 available GRID1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GRID1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for GRID1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GRID1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for GRID1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for GRID1
Cell Line Products
-
Horizon Cell Lines for GRID1
-
ViGene Biosciences adenoviral particle packaged cDNA for GRID1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GRID1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GRID1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRID1 Gene
Localization for GRID1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GRID1 Gene
- Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0030054 | cell junction | IEA | -- |
| GO:0045202 | synapse | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GRID1 Gene
Pathways & Interactions for GRID1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | MECP2 and Associated Rett Syndrome | ||
Pathways by source for GRID1 Gene
1 BioSystems pathway for GRID1 Gene
1 KEGG pathway for GRID1 Gene
Interacting Proteins for GRID1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006811 | ion transport | IEA | -- |
| GO:0034220 | ion transmembrane transport | IEA | -- |
| GO:0035176 | social behavior | IEA,ISS | -- |
| GO:0035235 | ionotropic glutamate receptor signaling pathway | IEA | -- |
No data available for SIGNOR curated interactions for GRID1 Gene
Drugs & Compounds for GRID1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Glutamic Acid | Approved | Nutra | Full agonist, Agonist, Target | 251 | ||
| Latrepirdine | Investigational | Pharma | Brain cell death inhibitor | 0 | ||
| ADX-47273 | Pharma | 0 | ||||
| IEM 1754 dihydrobroMide | Pharma | 0 | ||||
| Ifenprodil Tartrate | Pharma | NMDA receptor antagonist | 0 |
(8) ApexBio Compounds for GRID1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| ADX-47273 | 851881-60-2 | |
| IEM 1754 dihydrobroMide | 162831-31-4 | |
| Ifenprodil Tartrate | NMDA receptor antagonist | 23210-58-4 |
| Latrepirdine | Brain cell death inhibitor | 97657-92-6 |
| NMDA (N-Methyl-D-aspartic acid) | NMDA receptor agonist | 6384-92-5 |
| VU 0361737 | MGlu4 receptor allosteric modulator | 1161205-04-4 |
| VU 0364439 | Positive allosteric mGluR-4 modulator | 1246086-78-1 |
| VU 0364770 | 61350-00-3 |
Transcripts for GRID1 Gene
mRNA/cDNA for GRID1 Gene
- (2) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (29) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GRID1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GRID1
- genomics-online: gRNA clones - Search results for 92 available GRID1 gene related products
- Overview of 92 available GRID1 gene related products
- Applied Biological Materials CRISPR for GRID1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRID1
- GenScript: Design CRISPR guide RNA sequences for GRID1
miRNA Products
- Search ViGene Biosciences for GRID1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for GRID1
- Browse OriGene Inhibitory RNA Products For GRID1
- genomics-online: shRNA clones - Search results for 92 available GRID1 gene related products
- Overview of 92 available GRID1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GRID1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for GRID1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GRID1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for GRID1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for GRID1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||
| SP3: |
Expression for GRID1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Eye (Sensory Organs)
- nGnG Amacrine Cells Inner Nuclear Layer
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- nGnG Amacrine Cells Inner Nuclear Layer
- GABAergic Amacrine Cells Inner Nuclear Layer
This gene is overexpressed in CD4 Tcells (24.8), Frontal cortex (24.5), Fetal Brain (8.3), and Adipocyte (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GRID1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of GRID1 Gene:
GRID1SOURCE GeneReport for Unigene cluster for GRID1 Gene:
Hs.530653Evidence on tissue expression from TISSUES for GRID1 Gene
- Nervous system(4.4)
- Liver(4.2)
- Lung(3.1)
Primer Products
-
OriGene qPCR primer pairs for GRID1
- genomics-online: primer clones - Search results for 92 available GRID1 gene related products
- Overview of 92 available GRID1 gene related products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRID1 Gene
Orthologs for GRID1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GRID1 34 |
|
OneToOne | |
| LOC100612556 33 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | GRID1 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GRID1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | GRID1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Grid1 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | GRID1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GRID1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | GRID1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | grid1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | grid1a 34 |
|
OneToMany | |
| grid1b 33 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Glu-RI 34 |
|
ManyToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | glr-2 34 |
|
ManyToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for GRID1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for GRID1 Gene
Paralogs for GRID1 Gene
(7) SIMAP similar genes for GRID1 Gene using alignment to 3 proteins:
Variants for GRID1 Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs143353694 | uncertain-significance, Malignant tumor of prostate | 85,869,077(-) | G/A | coding_sequence_variant, missense_variant | |
| rs201182031 | benign, Abnormality of neuronal migration | 86,206,442(-) | G/A | coding_sequence_variant, missense_variant | |
| rs863223382 | benign, Abnormality of neuronal migration | 86,206,447(-) | G/A | coding_sequence_variant, missense_variant | |
| rs1000000131 | -- | 86,123,206(-) | C/G | intron_variant | |
| rs1000006196 | -- | 85,800,034(-) | G/A | intron_variant |
Residual Variation Intolerance Score:
2.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.27;
70.27% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GRID1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRID1 Gene
Disorders for GRID1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bipolar i disorder |
|
|
| rett syndrome |
|
|
Search GRID1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GRID1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for GRID1 Gene
Publications for GRID1 Gene
- Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoter. (PMID: 19346103) Treutlein J … Rietschel M (Schizophrenia research 2009) 3 22 44 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. (PMID: 19584346) Vasan RS … Blankenberg S (JAMA 2009) 3 44 58
- A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population. (PMID: 17490860) Guo SZ … He L (Schizophrenia research 2007) 3 44 58
- Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. (PMID: 16380905) Fallin MD … Pulver AE (American journal of human genetics 2005) 3 44 58
Products for GRID1 Gene
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- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for GRID1
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
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- Browse Cell Selection and Detection Kits
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- Custom Antibody ServicesOriGene Antibodies for GRID1
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For GRID1
- GenScript: Next-day shipping of latest version cDNA ORF clones for GRID1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for GRID1
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- GenScript Custom overexpressing Cell Line Services for GRID1
- GenScript: Design CRISPR guide RNA sequences for GRID1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for GRID1
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for GRID1
- Novus Biologicals proteins for GRID1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for GRID1
- Abcam proteins for GRID1
- Find your target
- Browse Primary Antibodies
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- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
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- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for GRID1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for GRID1
- Cyagen custom Knockout/knockin (KOKI) mouse models for GRID1
- VectorBuilder custom plasmid, inducible vectors for GRID1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GRID1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 68 available GRID1 Antibodies ranked by validation data
- Compare Top GRID1 Antibodies
- antibodies-online: Search results for 12 available GRID1 Elisa Kits ranked by validation data
- Compare Top GRID1 Elisa Kits
- antibodies-online: Search results for 9 available GRID1 Proteins ranked by validation data
- Compare Top GRID1 Proteins
- Quality Products:
- GeneTex GRID1 antibody for GRID1
- Search GeneTex for Proteins for GRID1
- ViGene Biosciences adenoviral particle packaged cDNA for GRID1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for GRID1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for GRID1 gene
- Search ViGene Biosciences for GRID1
- Santa Cruz Biotechnology (SCBT) Antibodies for GRID1
- Search Santa Cruz Biotechnology (SCBT) for GRID1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GRID1
- Horizon Cell Lines for GRID1
- genomics-online: cdna clones - Search results for 92 available GRID1 gene related products
- Overview of 92 available GRID1 gene related products
- orf clones - Search results for 92 available GRID1 gene related products
- Overview of 92 available GRID1 gene related products
- genomics-online: gRNA clones - Search results for 92 available GRID1 gene related products
- Overview of 92 available GRID1 gene related products
- genomics-online: primer clones - Search results for 92 available GRID1 gene related products
- Overview of 92 available GRID1 gene related products
- genomics-online: shRNA clones - Search results for 92 available GRID1 gene related products
- Overview of 92 available GRID1 gene related products
Sources for GRID1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew