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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GRIA4 Gene

protein-coding   GIFtS: 64
GCID: GC11P105514

Glutamate Receptor, Ionotropic, AMPA 4

(Previous names: glutamate receptor, ionotrophic, AMPA 4)
(Previous symbol: GLUR4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Glutamate Receptor, Ionotropic, AMPA 41 2     gluR-42
GLUR41 2 3 5     gluR-D2
Glutamate Receptor, Ionotrophic, AMPA 41 2     Glutamate Receptor 42
GluA42 3     GluR-43
AMPA-Selective Glutamate Receptor 42 3     GluR-D3
GLUR4C2     GluR43
GLURD2     Glutamate Receptor Ionotropic, AMPA 43

External Ids:    HGNC: 45741   Entrez Gene: 28932   Ensembl: ENSG000001525787   OMIM: 1382465   UniProtKB: P480583   

Export aliases for GRIA4 gene to outside databases

Previous GC identifers: GC11P107674 GC11P106838 GC11P105018 GC11P104986 GC11P101412


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GRIA4 Gene:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are
activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes
composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate
receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene
belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate
receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in
transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some
haplotypes of this gene show a positive association with schizophrenia. (provided by RefSeq, Jul 2008)

GeneCards Summary for GRIA4 Gene: 
GRIA4 (glutamate receptor, ionotropic, AMPA 4) is a protein-coding gene. Diseases associated with GRIA4 include schizophrenia, and major depressive disorder, and among its related super-pathways are Retrograde endocannabinoid signaling and Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell. GO annotations related to this gene include ionotropic glutamate receptor activity and extracellular-glutamate-gated ion channel activity. An important paralog of this gene is GRIA3.

UniProtKB/Swiss-Prot: GRIA4_HUMAN, P48058
Function: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and
plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter
at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a
conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an
electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized
by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is
characterized by a delayed accumulation of current flux upon continued application of glutamate

summary for GRIA4 Gene:
AMPA receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and
kainate receptors. AMPA receptors mediate fast excitatory synaptic transmission in the CNS and play a key
role in hippocampal synaptic long-term potentiation (LTP) and depression (LTD). AMPA receptors consist of
GluR1-4 subunits which assemble as homomers or heteromers to form functional AMPA receptors. The subunit
composition determines the physiological properties of AMPA receptors: those containing the GluR2 subunit
show low permeability to Ca2+ whereas those lacking this subunit show high Ca2+ permeability.

Gene Wiki entry for GRIA4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GRIA4 gene promoter:
         FOXI1   AREB6   FOXO4   NF-E2   NF-E2 p45   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRIA4 promoter sequence
   Search SABiosciences Chromatin IP Primers for GRIA4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRIA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22

GRIA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRIA4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P105514:  view genomic region     (about GC identifiers)

Start:
105,480,721 bp from pter      End:
105,852,819 bp from pter
Size:
372,099 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GRIA4_HUMAN, P48058 (See protein sequence)
Recommended Name: Glutamate receptor 4 precursor  
Size: 902 amino acids; 100871 Da
Subunit: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by
the dimerization of dimers. Interacts with EPB41L1 via its C-terminus (By similarity). Found in a complex with
GRIA1, GRIA2, GRIA3, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5 and
PRKCG (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell
membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Interaction with CNIH2, CNIH3 and PRKCG
promotes cell surface expression (By similarity)
Miscellaneous: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to
their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate
Secondary accessions: Q86XE8
Alternative splicing: 2 isoforms:  P48058-1   P48058-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GRIA4: NX_P48058

Explore proteomics data for GRIA4 at MOPED 

Post-translational modifications:

  • UniProtKB: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and
    decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression
    but regulates stimulation-dependent endocytosis (By similarity)
  • UniProtKB: Phosphorylated at Ser-862 by PRKCG; phosphorylation increases plasma membrane-associated GRI4 expression (By
    similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P48058

  • GRIA4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GRIA4 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_000820.3  NP_001070711.2  NP_001070712.1  NP_001106283.1  

    ENSEMBL proteins: 
     ENSP00000436449   ENSP00000376833   ENSP00000436143   ENSP00000432371   ENSP00000433621  
     ENSP00000415551   ENSP00000432443   ENSP00000432180   ENSP00000435775   ENSP00000433873  
     ENSP00000282499   ENSP00000376835  
    Reactome Protein details: P48058
    Human Recombinant Protein Products for GRIA4: 
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    Cloud-Clone Corp. Proteins for GRIA4 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane ----
    GO:0030054cell junction IEA--
    GO:0030425dendrite IEA--

    GRIA4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GRI: Ligand-gated ion channels / Glutamate receptors, ionotropic
    GR: Glutamate receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GluA4 
    Ionotropic glutamate receptors

    4 InterPro protein domains:
     IPR019594 Glu_rcpt_Glu/Gly-bd
     IPR001320 Iontro_glu_rcpt
     IPR001828 ANF_lig-bd_rcpt
     IPR001508 NMDA_rcpt

    Graphical View of Domain Structure for InterPro Entry P48058

    ProtoNet protein and cluster: P48058

    3 Blocks protein domains:
    IPB001320 Ionotropic glutamate receptor
    IPB001508 NMDA receptor signature
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GRIA4_HUMAN, P48058
    Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA4 subfamily


    GRIA4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRIA4_HUMAN, P48058
    Function: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and
    plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter
    at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a
    conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an
    electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized
    by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is
    characterized by a delayed accumulation of current flux upon continued application of glutamate

         Genatlas biochemistry entry for GRIA4:
    glutamate receptor,subunit 4,ionotropic,AMPA (amino-3-hydroxy 5 methyl-isoxazole-propionic) class,with flip and
    flop isoforms,mediating the fast component of excitatory post synaptic currents in the central nervous
    system,interacting with and signaling through the protein-kinase LYN

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004970ionotropic glutamate receptor activity ISS--
    GO:0004971alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity IDA--
    GO:0005215transporter activity ----
    GO:0005234extracellular-glutamate-gated ion channel activity IEA--
    GO:0005515protein binding ----
         
    GRIA4 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Gria4):
     behavior/neurological  growth/size  homeostasis/metabolism  integument  nervous system 
     no phenotypic analysis 

    GRIA4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GRIA4: Gria4tm1Rlh Gria4tm1Ksak Gria4tm1Dgen Gria4tm1.1Mony Gria4tm1Yfkk Gria4tm2.1Rlh

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    SwitchGear 3'UTR luciferase reporter plasmidGRIA4 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GRIA4 About   (see all 18)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Circadian entrainment
    Retrograde endocannabinoid signaling0.51
    Glutamatergic synapse0.39
    Circadian entrainment0.40
    Dopaminergic synapse0.37
    2Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.67
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    3Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
    Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity0.53
    Trafficking of GluR2-containing AMPA receptors0.53
    Trafficking of AMPA receptors0.53
    4CREB Pathway
    CREB Pathway0.68
    Intracellular Calcium Signaling0.50
    5Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling0.98

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for GRIA4
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Glutamic acid signaling
    Calcium channels

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GRIA4
        Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Pathogenesis of ALS
    CREB Pathway
    Intracellular Calcium Signaling
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    1 Cell Signaling Technology (CST) Pathway for GRIA4
        Neuroscience

    1 GeneGo (Thomson Reuters) Pathway for GRIA4
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    1 BioSystems Pathway for GRIA4
        Hypothetical Network for Drug Addiction

    5/9        Reactome Pathways for GRIA4 (see all 9)
        Unblocking of NMDA receptor, glutamate binding and activation
    Transmission across Chemical Synapses
    Activation of AMPA receptors
    Neuronal System
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell


    5/7         Kegg Pathways  (Kegg details for GRIA4) (see all 7):
        Neuroactive ligand-receptor interaction
    Circadian entrainment
    Retrograde endocannabinoid signaling
    Glutamatergic synapse
    Dopaminergic synapse


    GRIA4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRIA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/40 Interacting proteins for GRIA4 (P480582, 3 ENSP000002824994) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKACAP176122, 3, ENSP000003095914MINT-13729 MINT-49874 I2D: score=2 STRING: ENSP00000309591
    CAMK2AQ9UQM72, 3, ENSP000003814124MINT-17826 I2D: score=1 STRING: ENSP00000381412
    SDCBPO005603, ENSP000002601304I2D: score=3 STRING: ENSP00000260130
    GRIA2P422623, ENSP000002644264I2D: score=2 STRING: ENSP00000264426
    PRKCGP051293, ENSP000002634314I2D: score=2 STRING: ENSP00000263431
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS8589990
    GO:0007215glutamate receptor signaling pathway TAS8589990
    GO:0007268synaptic transmission TAS--
    GO:0035235ionotropic glutamate receptor signaling pathway ISS--

    GRIA4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GRIA4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GRIA4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CNQX disodium saltPotent AMPA/kainate antagonist. More water soluble form of CNQX (Cat. No. 0190)[115066-14-3]
    Naspm trihydrochlorideCa2+-permeable AMPA receptor antagonist[122306-11-0]
    NBQXPotent AMPA antagonist. More selective than CNQX (Cat. No. 0190)[118876-58-7]
    DNQX disodium saltSelective non-NMDA antagonist. Water-soluble salt of DNQX (Cat. No. 0189)[2379-57-9]
    NBQX disodium saltPotent AMPA antagonist. More water soluble form of NBQX (Cat. No. 0373)[118876-58-7]

    1 DrugBank Compound for GRIA4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--7679210 12008069 17139284 11406192 17016423

    10/21 IUPHAR Ligands for GRIA4 (GluA4) (see all 21)    About this table 
    LigandTypeActionAffinityPubmed IDs
    S18986
    Allosteric regulatorPositive--
    LY392098
    Allosteric regulatorPositive--
    CX546
    Allosteric regulatorPositive--
    CX516
    Allosteric regulatorPositive--
    argiotoxin
    Channel blockerNone--
    joro toxin
    Channel blockerNone--
    piracetam
    Allosteric regulatorPositive--
    [3H]CNQX
    NoneNone--
    ATPO
    AntagonistAntagonist--
    GYKI53655
    AntagonistAntagonist--

    7 Novoseek inferred chemical compound relationships for GRIA4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 75.8 22 15255946 (2), 15634782 (1), 9437035 (1), 8873866 (1) (see all 17)
    kainate 73.4 8 10448859 (1), 12008069 (1), 15255946 (1), 18087239 (1) (see all 6)
    alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid 69.3 2 17432955 (1), 9388556 (1)
    nmda 64.5 10 9538905 (2), 7504083 (1), 10448859 (1), 17924980 (1) (see all 6)
    gaba 24.7 2 19492025 (1), 10235640 (1)
    calcium 0.301 2 12008069 (1), 17432955 (1)
    dopamine 0.14 1 15255946 (1)

    Search CenterWatch for drugs/clinical trials and news about GRIA4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for GRIA4 gene (4 alternative transcripts): 
    NM_000829.3  NM_001077243.2  NM_001077244.1  NM_001112812.1  

    Unigene Cluster for GRIA4:

    Glutamate receptor, ionotropic, AMPA 4
    Hs.503743  [show with all ESTs]
    Unigene Representative Sequence: NM_001077243
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527177 ENST00000393125(uc001piu.1) ENST00000531986 ENST00000527669(uc001pit.3)
    ENST00000525921 ENST00000525032(uc001piv.3) ENST00000428631(uc009yxk.1)
    ENST00000531011 ENST00000525187 ENST00000530497 ENST00000527687 ENST00000525942(uc010rvm.1)
    ENST00000533094 ENST00000282499(uc001pix.2) ENST00000393127(uc001piw.2 uc009yxl.1)


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    Additional mRNA sequence: 

    AB115416.1 AB209092.1 AK311193.1 BC015199.1 BC035610.1 BC045546.1 BC114549.1 BC142654.1 
    BC146816.1 BC150209.1 FJ947075.1 FJ947076.1 JN547407.1 NR_046356.1 U16129.1 

    10 DOTS entries:

    DT.210648  DT.101969850  DT.40194019  DT.102825266  DT.40111045  DT.106431  DT.92020336  DT.120760481 
    DT.97822773  DT.40130672 

    24/40 AceView cDNA sequences (see all 40):

    BM726613 BX431201 BM665840 CA398023 CA398022 AL134656 BM681259 H46078 
    BC045546 AW295058 BQ717001 CK004407 BI757498 BC035610 BX418744 N52193 
    NM_000829 AL133882 BM661705 BC015199 CB153467 R93820 U16129 BM548364 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GRIA4 expression in normal human tissues (normalized intensities)      GRIA4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTCCCCC
    GRIA4 Expression
    About this image


    GRIA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Kidney (Urinary System)    fully expand to see all 7 entries
             Metanephros
             visceral organ/mesonephros of female/mesonephric mesenchyme of female mesonephros   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 6 entries
             visceral organ   
     
     Brain (Nervous System)    fully expand to see all 5 entries
             ganglion/cranial/facial VII   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 3 entries
             autonomic/sympathetic/ganglion   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
             retinal progenitor cell e16.5   

    See GRIA4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GRIA4

    SOURCE GeneReport for Unigene cluster: Hs.503743
        SABiosciences Expression via Pathway-Focused PCR Arrays including GRIA4: 
              GABA & Glutamate in human mouse rat
              Synaptic Plasticity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GRIA4 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gria41 , 5 glutamate receptor, ionotropic, AMPA4 (alpha 4)1, 5 91.98(n)1
    99.67(a)1
      9 (2.46 cM)5
    148021  NM_019691.41  NP_062665.31 
     44178995 
    chicken
    (Gallus gallus)
    Aves GRIA41 glutamate receptor, ionotrophic, AMPA 4 88.1(n)
    95.34(a)
      396137  NM_205214.2  NP_990545.1 
    lizard
    (Anolis carolinensis)
    Reptilia GRIA46
    glutamate receptor, ionotropic, AMPA 4
    91(a)
    1 ↔ 1
    3(190375530-190707840)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.136662 Danio rerio AMPA receptor subunit GluR4A (glur4a) mRNA, more 77.8(n)    AF525747.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG111553 kainate selective glutamate receptor 51(a)
    (best of 9)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea glr-13 Expression: neurons, RMD neurons, SMD
    neurons, more
    49(a)
    (best of 2)
      III(8655978-8660337)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GLR3.41 glutamate receptor 3.4 40.4(n)
    26.18(a)
      839268  NM_100398.2  NP_172012.2 
    rice
    (Oryza sativa)
    Liliopsida Os06g06805001 hypothetical protein 38.24(n)
    22.13(a)
      4341854  NM_001064907.1  NP_001058372.1 


    ENSEMBL Gene Tree for GRIA4 (if available)
    TreeFam Gene Tree for GRIA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GRIA4 gene
    GRIA32  GRIN2D2  GRIK12  GRIA22  GRIN12  GRIK22  GRIA12  GRIK42  
    GRIK32  GRIN3A2  GRIN2B2  GRIN2A2  GRIK52  GRIN3B2  GRIN2C2  GRID12  
    GRID22  
    11 SIMAP similar genes for GRIA4 using alignment to 10 protein entries:     GRIA4_HUMAN (see all proteins):
    GluR4c    GRIA2    GRIA1    GRIA3    GRIK2    GRIK1
    GRIK3    GRIK5    GRIK4    GRID2    GRID1

    GRIA4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6574 SNPs in GRIA4 are shown (see all 6574)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1908609621,2
    Cuntested1105517565(+) AAAACC/TCTGGA 5 -- int10--------
    rs563141661,2
    C--101431261(+) AAATA-/AATAAATA/AA
    TAAATAAATAAATA
    GAGAC
    5 -- int11NA 2
    rs1889265651,2
    --105478832(+) AACTAC/TTTGAC 3 -- us2k10--------
    rs1498582961,2
    --105478866(+) TATATA/TCGTAT 3 -- us2k10--------
    rs1812983801,2
    --105478918(+) AAAATA/GTATTT 3 -- us2k10--------
    rs1475281761,2
    --105479006(+) TAACTA/GCTTGG 3 -- us2k10--------
    rs1401203261,2
    --105479090(+) CCAGGC/TGTTAT 3 -- us2k10--------
    rs1839833311,2
    --105479151(+) TGCTAC/TTACAT 3 -- us2k10--------
    rs1884655481,2
    --105479168(+) AAAACC/TGAAAT 3 -- us2k10--------
    rs1455322811,2
    --105479203(+) GTTAAC/TAATTG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for GRIA4 (105480721 - 105730721 bp, first 250kb of GRIA4)

    Structural Variations
         Database of Genomic Variants (DGV) 10/19 variations for GRIA4 (see all 19):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672300CNV Deletion23128226
    esv2599683CNV Deletion19546169
    esv2669612CNV Deletion23128226
    esv2658816CNV Deletion23128226
    esv2000018CNV Deletion18987734
    esv2745021CNV Deletion23290073
    esv2520318CNV Deletion19546169
    esv2745023CNV Deletion23290073
    esv4809CNV Deletion18987735
    esv2745022CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 138246    OMIM disorders: --

    14 diseases for GRIA4:    About MalaCards
    schizophrenia    major depressive disorder    amyotrophic lateral sclerosis    lateral sclerosis
    huntington's disease    bipolar disorder    ischemia    multiple sclerosis
    parkinson's disease    glioblastoma    cerebritis    retinitis
    neuronitis    endotheliitis


    GRIA4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for GRIA4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    epilepsy 5.88 1 9455976 (1)
    schizophrenia 3.35 8 15450689 (4), 12497607 (3)

    Genetic Association Database (GAD): GRIA4
    Human Genome Epidemiology (HuGE) Navigator: GRIA4 (9 documents)

    Export disorders for GRIA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GRIA4 gene, integrated from 9 sources (see all 104):
    (articles sorted by number of sources associating them with GRIA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. No genetic association between polymorphisms in the AMPA receptor subunit GluR4 gene (GRIA4) and schizophrenia in the Chinese population. (PubMed id 15450689)1, 4, 9 Guo S....He L. (2004)
    2. Positive association of the AMPA receptor subunit GluR4 gene (GRIA4) haplotype with schizophrenia: linkage disequilibrium mapping using SNPs evenly distributed across the gene region. (PubMed id 12497607)1, 4, 9 Makino C....Fukumaki Y. (2003)
    3. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (2009)
    4. Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia. (PubMed id 19125103)1, 4 Arai S....Fukumaki Y. (2009)
    5. Applicability of a genetic signature for enhanced ilo peridone efficacy in the treatment of schizophrenia. (PubMed id 19573479)1, 4 Volpi S....Lavedan C. (2009)
    6. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    7. Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study. (PubMed id 18521090)1, 4 Lavedan C....Polymeropoulos M.H. (2008)
    8. Study on GRIA2, GRIA3 and GRIA4 genes highlights a positive association between schizophrenia and GRIA3 in female patients. (PubMed id 18163426)1, 4 Magri C....Barlati S. (2007)
    9. Cloning, expression and pharmacological characterization of a human glutamate receptor: hGluR4. (PubMed id 8589990)1, 2 Fletcher E.J.... Kamboj R.K. (1995)
    10. PKC anchoring to GluR4 AMPA receptor subunit modulates PKC-driven receptor phosphorylation and surface expression. (PubMed id 17233759)1, 9 Gomes A.R....Carvalho A.L. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2893 HGNC: 4574 AceView: GRIA4 Ensembl:ENSG00000152578 euGenes: HUgn2893
    ECgene: GRIA4 Kegg: 2893 H-InvDB: GRIA4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GRIA4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GRIA4 gene:
    Search GeneIP for patents involving GRIA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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