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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GRIA4 Gene

protein-coding   GIFtS: 65
GCID: GC11P105514

glutamate receptor, ionotropic, AMPA 4

(Previous names: glutamate receptor, ionotrophic, AMPA 4 )
(Previous symbol: GLUR4)
 Explore 11 diseases affiliated with
GRIA4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GRIA4    

Aliases
for GRIA4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Glutamate Receptor, Ionotropic, AMPA 41 2     GluR-43
GLUR41 2 3 5     GluR-D3
GluA41 2 3     Glutamate Receptor 42
GLURD1 2     GluR-43
Glutamate Receptor, Ionotrophic, AMPA 41 2     GluR-D3
AMPA-Selective Glutamate Receptor 42 3     GluR43
GLUR4C2     Glutamate Receptor Ionotropic, AMPA 43

External Ids:    HGNC: 45741   Entrez Gene: 28932   Ensembl: ENSG000001525787   OMIM: 1382465   UniProtKB: P480583   

Export aliases for GRIA4 gene to outside databases

Previous GC identifers: GC11P107674 GC11P106838 GC11P105018 GC11P104986 GC11P101412


Summaries
for GRIA4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GRIA4:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated
in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of
multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on
their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA
(alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing
(AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms,
which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with
schizophrenia. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GRIA4_HUMAN, P48058
Function: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an
important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many
synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation
change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical
impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence
of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a
delayed accumulation of current flux upon continued application of glutamate

summary for GRIA4:
AMPA receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and
kainate receptors. AMPA receptors mediate fast excitatory synaptic transmission in the CNS and play a key
role in hippocampal synaptic long-term potentiation (LTP) and depression (LTD). AMPA receptors consist of
GluR1-4 subunits which assemble as homomers or heteromers to form functional AMPA receptors. The subunit
composition determines the physiological properties of AMPA receptors: those containing the GluR2 subunit
show low permeability to Ca2+ whereas those lacking this subunit show high Ca2+ permeability.

Gene Wiki entry for GRIA4


Genomic Views
for GRIA4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GRIA4 gene promoter:
         FOXI1   AREB6   FOXO4   NF-E2   NF-E2 p45   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GRIA4 promoter sequence
   Search SABiosciences Chromatin IP Primers for GRIA4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRIA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22

GRIA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRIA4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P105514:  view genomic region     (about GC identifiers)

Start:
 105,480,721 bp from pter      End:
 105,852,819 bp from pter
Size:
 372,099 bases      Orientation:
 plus strand

Proteins
for GRIA4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GRIA4_HUMAN, P48058 (See protein sequence)
Recommended Name: Glutamate receptor 4 precursor  
Size: 902 amino acids; 100871 Da
Subunit: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the
dimerization of dimers. Interacts with EPB41L1 via its C-terminus (By similarity). Found in a complex with GRIA1,
GRIA2, GRIA3, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5 and PRKCG (By
similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane;
Multi-pass membrane protein. Cell projection, dendrite. Note=Interaction with CNIH2, CNIH3 and PRKCG promotes cell
surface expression (By similarity)
Miscellaneous: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their
selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate
Secondary accessions: Q86XE8
Alternative splicing: 2 isoforms:  P48058-1   P48058-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GRIA4: NX_P48058

Post-translational modifications:

  • Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and
    • decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but
    regulates stimulation-dependent endocytosis (By similarity)1
  • Phosphorylated at Ser-862 by PRKCG; phosphorylation increases plasma membrane-associated GRI4 expression (By
    • similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P48058

    • GRIA4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_000820.3  NP_001070711.2  NP_001070712.1  NP_001106283.1  

    ENSEMBL proteins: 
     ENSP00000436449   ENSP00000376833   ENSP00000436143   ENSP00000432371   ENSP00000433621  
     ENSP00000415551   ENSP00000432443   ENSP00000432180   ENSP00000435775   ENSP00000433873  
     ENSP00000282499   ENSP00000376835  
    Reactome Protein details: P48058
    Human Recombinant Protein Products: 
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    Uscn Proteins for GRIA4

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0014069postsynaptic density ----
    GO:0016021integral to membrane ----
    GO:0030054cell junction IEA--
    GO:0030425dendrite IEA--


    GRIA4 for ontologies           About GeneDecksing



    GRIA4 Antibody Products: 
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    Uscn ELISAs and CLIAs for GRIA4

    Protein Domains /
    Families
    for GRIA4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GRIA4 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR019594 Glu_rcpt_Glu/Gly-bd
     IPR001320 Iontro_glu_rcpt
     IPR001828 ANF_lig-bd_rcpt
     IPR001508 NMDA_rcpt

    Graphical View of Domain Structure for InterPro Entry P48058

    ProtoNet protein and cluster: P48058

    3 Blocks protein families:
    IPB001320 Ionotropic glutamate receptor
    IPB001508 NMDA receptor signature
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GRIA4_HUMAN, P48058
    Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA4 subfamily


    Function
    for GRIA4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GRIA4_HUMAN, P48058
    Function: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an
    important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many
    synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation
    change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical
    impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence
    of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a
    delayed accumulation of current flux upon continued application of glutamate

         Genatlas biochemistry entry for GRIA4:
    glutamate receptor,subunit 4,ionotropic,AMPA (amino-3-hydroxy 5 methyl-isoxazole-propionic) class,with flip and flop
    isoforms,mediating the fast component of excitatory post synaptic currents in the central nervous system,interacting
    with and signaling through the protein-kinase LYN

    miRNA
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    hsa-miR-4272 hsa-miR-128 hsa-miR-1258 hsa-miR-3074-3p hsa-miR-578 hsa-miR-4275 hsa-miR-1244 hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmid: GRIA4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GRIA4 (see all 7)
    OriGene shRNA RFP: GRIA4
    OriGene siRNA: GRIA4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRIA4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for GRIA4

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRIA4 (see all 9)
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004970ionotropic glutamate receptor activity ISS--
    GO:0004971alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity IDA--
    GO:0005234extracellular-glutamate-gated ion channel activity IEA--
    GO:0005515protein binding ----
    GO:0015277kainate selective glutamate receptor activity ISS--


    GRIA4 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for GRIA4: Gria4tm1Rlh Gria4tm1Ksak Gria4tm1Dgen Gria4tm1.1Mony Gria4tm1Yfkk Gria4tm2.1Rlh
         6 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Gria4):
     behavior/neurological  growth/size  homeostasis/metabolism  integument  nervous system 
     no phenotypic analysis 

    GRIA4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GRIA4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
    		Trafficking of AMPA receptors1.00
    		Trafficking of GluR2-containing AMPA receptors0.53
    		Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity1.00
    2Transmission across Chemical Synapses
    		Transmission across Chemical Synapses1.00
    		Neuronal System0.67
    		Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    3Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    		Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling1.00
    		Neurophysiological process_Glutamate regulation of Dopamine D1A receptor signaling0.98
    4CREB Pathway
    		CREB Pathway1.00
    		Intracellular Calcium Signaling0.50
    5Neuroscience
    		Neuroscience1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for GRIA4
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Glutamic acid signaling
    Calcium channels

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GRIA4
        Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Pathogenesis of ALS
    CREB Pathway
    Intracellular Calcium Signaling
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    1 Cell Signaling Technology (CST) Pathway for GRIA4
        Neuroscience

    1 GeneGo (Thomson Reuters) Pathway for GRIA4
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    1 BioSystems Pathway for GRIA4 
        Hypothetical Network for Drug Addiction

    5/9        Reactome Pathways for GRIA4 (see all 9)
        Unblocking of NMDA receptor, glutamate binding and activation
    Transmission across Chemical Synapses
    Activation of AMPA receptors
    Neuronal System
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell


    2         Kegg Pathways  (Kegg details for GRIA4):
        Neuroactive ligand-receptor interaction
    Glutamatergic synapse


    GRIA4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRIA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/40 Interacting proteins for GRIA4 (P480582, 3 ENSP000002824994) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKACAP176122, 3, ENSP000003095914MINT-13729 MINT-49874 I2D: score=2 STRING: ENSP00000309591
    CAMK2AQ9UQM72, 3, ENSP000003814124MINT-17826 I2D: score=1 STRING: ENSP00000381412
    SDCBPO005603, ENSP000002601304I2D: score=3 STRING: ENSP00000260130
    GRIA2P422623, ENSP000002644264I2D: score=2 STRING: ENSP00000264426
    PRKCGP051293, ENSP000002634314I2D: score=2 STRING: ENSP00000263431
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS8589990
    GO:0007215glutamate receptor signaling pathway TAS8589990
    GO:0007268synaptic transmission TAS--
    GO:0035235ionotropic glutamate receptor signaling pathway ISS--
    GO:0050804regulation of synaptic transmission ----


    GRIA4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GRIA4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GRIA4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GRIA4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (S)-AMPASelective AMPA agonist. Active isomer of (RS)-AMPA (Cat. No. 0169)[83643-88-3]
    GYKI 52466 dihydrochlorideSelective non-competitive AMPA antagonist[102771-26-6]
    A 769662Potent AMPK activator[844499-71-4]
    NBQX disodium saltPotent AMPA antagonist. More water soluble form of NBQX (Cat. No. 0373)[118876-58-7]
    GYKI 53655 hydrochlorideNon-competitive AMPA receptor antagonist[143692-48-2]

    1 DrugBank Compound for GRIA4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--7679210 12008069 17139284 11406192 17016423

    7 Novoseek chemical compound relationships for GRIA4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 75.8 22 15255946 (2), 15634782 (1), 9437035 (1), 8873866 (1) (see all 17)
    kainate 73.4 8 10448859 (1), 12008069 (1), 15255946 (1), 18087239 (1) (see all 6)
    alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid 69.3 2 17432955 (1), 9388556 (1)
    nmda 64.5 10 9538905 (2), 7504083 (1), 10448859 (1), 17924980 (1) (see all 6)
    gaba 24.7 2 19492025 (1), 10235640 (1)
    calcium 0.301 2 12008069 (1), 17432955 (1)
    dopamine 0.14 1 15255946 (1)

    Search CenterWatch for drugs/clinical trials and news about GRIA4 

    Transcripts
    for GRIA4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GRIA4 gene (4 alternative transcripts): 
    NM_000829.3  NM_001077243.2  NM_001077244.1  NM_001112812.1  

    Unigene Cluster for GRIA4:

    Glutamate receptor, ionotropic, AMPA 4
    Hs.503743  [show with all ESTs]
    Unigene Representative Sequence: NM_001077243
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527177 ENST00000393125(uc001piu.1) ENST00000531986 ENST00000527669(uc001pit.3)
    ENST00000525921 ENST00000525032(uc001piv.3) ENST00000428631(uc009yxk.1)
    ENST00000531011 ENST00000525187 ENST00000530497 ENST00000527687 ENST00000525942(uc010rvm.1)
    ENST00000533094 ENST00000282499(uc001pix.2) ENST00000393127(uc001piw.2 uc009yxl.1)


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    hsa-miR-4272 hsa-miR-128 hsa-miR-1258 hsa-miR-3074-3p hsa-miR-578 hsa-miR-4275 hsa-miR-1244 hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmid: GRIA4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GRIA4 (see all 7)
    OriGene shRNA RFP: GRIA4
    OriGene siRNA: GRIA4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRIA4
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): GRIA4 (NM_000829)
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    Primer
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    Additional cDNA sequence: 

    AB115416.1 AB209092.1 AK311193.1 BC015199.1 BC035610.1 BC045546.1 BC114549.1 BC142654.1 
    BC146816.1 BC150209.1 FJ947075.1 FJ947076.1 JN547407.1 NR_046356.1 U16129.1 

    10 DOTS entries:

    DT.210648  DT.101969850  DT.40194019  DT.102825266  DT.40111045  DT.106431  DT.92020336  DT.120760481 
    DT.97822773  DT.40130672 

    24/40 AceView cDNA sequences (see all 40):

    BM681259 CA398022 BX431201 BQ717001 AL134656 BM665840 AW295058 CA398023 
    BM726613 BC045546 H46078 CK004407 AL133882 NM_000829 BM548364 CB153467 
    R93820 BF796432 BM661705 U16129 BI757498 BC015199 BC035610 N52193 

    GeneLoc Exon Structure


    Expression
    for GRIA4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GRIA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTTTCCCCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GRIA4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    Reproductive SystemMesonephrosMesonephric cellsReproductive System
    EyeRetinaEye
    KidneyEpithelial TubuleKidney
    KidneyMetanephrosKidney
    Reproductive SystemMesonephrosReproductive System
    Reproductive SystemVas DeferensReproductive System
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See GRIA4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GRIA4

    SOURCE GeneReport for Unigene cluster: Hs.503743
        SABiosciences Expression via Pathway-Focused PCR Arrays including GRIA4: 
              GABA & Glutamate in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for GRIA4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GRIA4 gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GRIA41 glutamate receptor, ionotrophic, AMPA 4 88.1(n)
    95.34(a)    		   396137  NM_205214.2  NP_990545.1 
    lizard
    (Anolis carolinensis)    		 Reptilia GRIA46
    		 --
    		 94(a)
    		 1 ↔ 1
    		 3(190377067-190707209)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.136662 Danio rerio AMPA receptor subunit GluR4A (glur4a) mRNA, more 77.8(n)    AF525747.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG111553 kainate selective glutamate receptor 51(a)
    (best of 9)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea glr-13 Expression: neurons, RMD neurons, SMD
    neurons, more    		 49(a)
    (best of 2)    		   III(8655978-8660337)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons GLR3.41 glutamate receptor 3.4 40.4(n)
    26.18(a)    		   839268  NM_100398.2  NP_172012.2 
    rice
    (Oryza sativa)    		 Liliopsida Os06g06805001 hypothetical protein 38.24(n)
    22.13(a)    		   4341854  NM_001064907.1  NP_001058372.1 


    ENSEMBL Gene Tree for GRIA4 (if available)
    TreeFam Gene Tree for GRIA4 (if available) 

    Paralogs
    for GRIA4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GRIA4 gene
    GRIA32  GRIN2D2  GRIK12  GRIA22  GRIK22  GRIN12  GRIA12  GRIK42  
    GRIK32  GRIN3A2  GRIN2B2  GRIN2A2  GRIK52  GRIN3B2  GRIN2C2  GRID12  
    GRID22  
    11 SIMAP similar genes for GRIA4 using alignment to 10 protein entries:     GRIA4_HUMAN (see all proteins):
    GluR4c    GRIA2    GRIA1    GRIA3    GRIK2    GRIK1
    GRIK3    GRIK5    GRIK4    GRID2    GRID1

    GRIA4 for paralogs           About GeneDecksing



    Genomic Variants
    for GRIA4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5649 NCBI SNPs in GRIA4 are shown (see all 5649)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1908609621,2
    		C,unknown105517565(+) AAAACC/TCTGGA 5 -- int10--------
    rs1889265651,2
    		--105478832(+) AACTAC/TTTGAC 3 -- us2k10--------
    rs1498582961,2
    		--105478866(+) TATATA/TCGTAT 3 -- us2k10--------
    rs1812983801,2
    		--105478918(+) AAAATA/GTATTT 3 -- us2k10--------
    rs1475281761,2
    		--105479006(+) TAACTA/GCTTGG 3 -- us2k10--------
    rs1401203261,2
    		--105479090(+) CCAGGC/TGTTAT 3 -- us2k10--------
    rs1839833311,2
    		--105479151(+) TGCTAC/TTACAT 3 -- us2k10--------
    rs1884655481,2
    		--105479168(+) AAAACC/TGAAAT 3 -- us2k10--------
    rs1455322811,2
    		--105479203(+) GTTAAC/TAATTG 3 -- us2k10--------
    rs1808217431,2
    		--105479345(+) GAATGC/TTATTA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for GRIA4 (105480721 - 105730721 bp, first 250kb of GRIA4)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for GRIA4
         3 CNVs: 101331 5645 101332
         7 Indels: 11577 42743 61187 39864 61186 44811 11578

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    Disorders / Diseases
    for GRIA4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GRIA4 for disorders           About GeneDecksing

    OMIM gene information: 138246    OMIM disorders: --

    11 diseases for GRIA4:    About MalaCards
    schizophrenia    amyotrophic lateral sclerosis    lateral sclerosis    multiple sclerosis
    huntington's disease    parkinson's disease    ischemia    glioblastoma
    cerebritis    retinitis    neuronitis

    2 Novoseek disease relationships for GRIA4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    epilepsy 5.88 1 9455976 (1)
    schizophrenia 3.35 8 15450689 (4), 12497607 (3)

    Genetic Association Database (GAD): GRIA4
    Human Genome Epidemiology (HuGE) Navigator: GRIA4 (9 documents)

    Export disorders for GRIA4 gene to outside databases

    Publications
    for GRIA4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GRIA4 gene, integrated from 9 sources (see all 103):
    (articles sorted by number of sources associating them with GRIA4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. No genetic association between polymorphisms in the AMPA receptor subunit GluR4 gene (GRIA4) and schizophrenia in the Chinese population. (PubMed id 15450689)1, 4, 9 Guo S....He L. (2004)
    2. Positive association of the AMPA receptor subunit GluR4 gene (GRIA4) haplotype with schizophrenia: linkage disequilibrium mapping using SNPs evenly distributed across the gene region. (PubMed id 12497607)1, 4, 9 Makino C....Fukumaki Y. (2003)
    3. Cloning, expression and pharmacological characterization of a human glutamate receptor: hGluR4. (PubMed id 8589990)1, 2 Fletcher E.J.... Kamboj R.K. (1995)
    4. PKC anchoring to GluR4 AMPA receptor subunit modulates PKC-driven receptor phosphorylation and surface expression. (PubMed id 17233759)1, 9 Gomes A.R....Carvalho A.L. (2007)
    5. GluR4c, an alternative splicing isoform of GluR4, is abundantly expressed in the adult human brain. (PubMed id 15306133)1, 9 Kawahara Y.... Kwak S. (2004)
    6. Characterization of the functional role of the N-glycans in the AMPA receptor ligand-binding domain. (PubMed id 12603841)1, 9 Pasternack A....Keinanen K. (2003)
    7. Expression of AMPA/kainate receptors during development of chick embryo retina cells: in vitro versus in vivo studies. (PubMed id 12008069)7, 9 Cristovao A.J....Carvalho C.M. (2002)
    8. Kinetic mechanism of channel opening of the GluRDflip AMPA receptor. (PubMed id 15823042)1, 9 Li G....Niu L. (2005)
    9. Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on d iagnosis and response to antipsychotic treatment in patients with schizophrenia. (PubMed id 22094384)1 Crisafulli C....Serretti A. (2012)
    10. Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on d iagnosis and response to treatment in patients with major depressive disorder. (PubMed id 22057216)1 Chiesa A....Pae C.U. (2012)

    External Searches for GRIA4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GRIA4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2893 HGNC: 4574 AceView: GRIA4 Ensembl:ENSG00000152578 euGenes: HUgn2893
    ECgene: GRIA4 Kegg: 2893 H-InvDB: GRIA4

    Other Databases showing GRIA4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GRIA4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GRIA4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for GRIA4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GRIA4 gene:
    Search GeneIP for patents involving GRIA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for GRIA4 gene

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