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Aliases for GRIA4 Gene

Aliases for GRIA4 Gene

  • Glutamate Receptor, Ionotropic, AMPA 4 2 3
  • GLUR4 3 4 6
  • Glutamate Receptor, Ionotrophic, AMPA 4 2 3
  • AMPA-Selective Glutamate Receptor 4 3 4
  • GluR-4 3 4
  • GluR-D 3 4
  • GluA4 3 4
  • Glutamate Receptor Ionotropic, AMPA 4 4
  • Glutamate Receptor 4 3
  • GLUR4C 3
  • GLURD 3

External Ids for GRIA4 Gene

Previous HGNC Symbols for GRIA4 Gene

  • GLUR4

Previous GeneCards Identifiers for GRIA4 Gene

  • GC11P107674
  • GC11P106838
  • GC11P105018
  • GC11P104986
  • GC11P101412

Summaries for GRIA4 Gene

Entrez Gene Summary for GRIA4 Gene

  • Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRIA4 Gene

GRIA4 (Glutamate Receptor, Ionotropic, AMPA 4) is a Protein Coding gene. Diseases associated with GRIA4 include schizophrenia. Among its related pathways are CREB Pathway and CREB Pathway. GO annotations related to this gene include extracellular-glutamate-gated ion channel activity and ionotropic glutamate receptor activity. An important paralog of this gene is GRID2.

UniProtKB/Swiss-Prot for GRIA4 Gene

  • Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Tocris Summary for GRIA4 Gene

  • AMPA receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and kainate receptors. AMPA receptors mediate fast excitatory synaptic transmission in the CNS and play a key role in hippocampal synaptic long-term potentiation (LTP) and depression (LTD). AMPA receptors consist of GluR1-4 subunits which assemble as homomers or heteromers to form functional AMPA receptors. The subunit composition determines the physiological properties of AMPA receptors: those containing the GluR2 subunit show low permeability to Ca2+ whereas those lacking this subunit show high Ca2+ permeability.

Gene Wiki entry for GRIA4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIA4 Gene

Genomics for GRIA4 Gene

Regulatory Elements for GRIA4 Gene

Genomic Location for GRIA4 Gene

Start:
105,609,994 bp from pter
End:
105,982,092 bp from pter
Size:
372,099 bases
Orientation:
Plus strand

Genomic View for GRIA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRIA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIA4 Gene

Proteins for GRIA4 Gene

  • Protein details for GRIA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48058-GRIA4_HUMAN
    Recommended name:
    Glutamate receptor 4
    Protein Accession:
    P48058
    Secondary Accessions:
    • Q86XE8

    Protein attributes for GRIA4 Gene

    Size:
    902 amino acids
    Molecular mass:
    100871 Da
    Quaternary structure:
    • Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with EPB41L1 via its C-terminus (By similarity). Found in a complex with GRIA1, GRIA2, GRIA3, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5 and PRKCG (By similarity).
    Miscellaneous:
    • The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate

    Alternative splice isoforms for GRIA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRIA4 Gene

Proteomics data for GRIA4 Gene at MOPED

Post-translational modifications for GRIA4 Gene

  • Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
  • Phosphorylated at Ser-862 by PRKCG; phosphorylation increases plasma membrane-associated GRI4 expression.
  • Glycosylation at Asn56, Asn258, Asn371, Asn407, and Asn414
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GRIA4 (GluR4)

No data available for DME Specific Peptides for GRIA4 Gene

Domains for GRIA4 Gene

Gene Families for GRIA4 Gene

HGNC:
  • GR :Glutamate receptors
  • GRI :Ligand-gated ion channels / Glutamate receptors, ionotropic
IUPHAR :

Suggested Antigen Peptide Sequences for GRIA4 Gene

Graphical View of Domain Structure for InterPro Entry

P48058

UniProtKB/Swiss-Prot:

GRIA4_HUMAN :
  • P48058
Domain:
  • The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA4 subfamily.
genes like me logo Genes that share domains with GRIA4: view

Function for GRIA4 Gene

Molecular function for GRIA4 Gene

GENATLAS Biochemistry: glutamate receptor,subunit 4,ionotropic,AMPA (amino-3-hydroxy 5 methyl-isoxazole-propionic) class,with flip and flop isoforms,mediating the fast component of excitatory post synaptic currents in the central nervous system,interacting with and signaling through the protein-kinase LYN
UniProtKB/Swiss-Prot Function: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Gene Ontology (GO) - Molecular Function for GRIA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004970 ionotropic glutamate receptor activity ISS --
GO:0004971 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity IDA 21172611
GO:0005234 extracellular-glutamate-gated ion channel activity IBA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with GRIA4: view
genes like me logo Genes that share phenotypes with GRIA4: view

Animal Models for GRIA4 Gene

MGI Knock Outs for GRIA4:

Animal Model Products

CRISPR Products

miRNA for GRIA4 Gene

miRTarBase miRNAs that target GRIA4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRIA4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GRIA4 Gene

Localization for GRIA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIA4 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Interaction with CNIH2, CNIH3 and PRKCG promotes cell surface expression. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRIA4 Gene COMPARTMENTS Subcellular localization image for GRIA4 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for GRIA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0030054 cell junction IEA --
GO:0030425 dendrite IBA --
genes like me logo Genes that share ontologies with GRIA4: view

Pathways for GRIA4 Gene

genes like me logo Genes that share pathways with GRIA4: view

PCR Array Products

Gene Ontology (GO) - Biological Process for GRIA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8589990
GO:0007215 glutamate receptor signaling pathway TAS 8589990
GO:0007268 synaptic transmission TAS --
GO:0034220 ion transmembrane transport IEA --
GO:0035235 ionotropic glutamate receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with GRIA4: view

Compounds for GRIA4 Gene

(5) Tocris Compounds for GRIA4 Gene

Compound Action Cas Number
CNQX disodium salt Potent AMPA/kainate antagonist. More water soluble form of CNQX (Cat. No. 0190) [479347-85-8]
DNQX Selective non-NMDA antagonist [2379-57-9]
DNQX disodium salt Selective non-NMDA antagonist. Water-soluble salt of DNQX (Cat. No. 0189) [1312992-24-7]
NBQX Potent AMPA antagonist. More selective than CNQX (Cat. No. 0190) [118876-58-7]
NBQX disodium salt Potent AMPA antagonist. More water soluble form of NBQX (Cat. No. 0373) [479347-86-9]

(1) Drugbank Compounds for GRIA4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target

(21) IUPHAR Ligand for GRIA4 Gene

Ligand Type Action Affinity Pubmed IDs
S18986 Allosteric regulator Positive
LY392098 Allosteric regulator Positive
CX546 Allosteric regulator Positive
CX516 Allosteric regulator Positive
argiotoxin Channel blocker None
joro toxin Channel blocker None
piracetam Allosteric regulator Positive
[3H]CNQX None None
ATPO Antagonist Antagonist
GYKI53655 Antagonist Antagonist
NBQX Antagonist Antagonist
GYKI53784 Antagonist Antagonist
AMPA Agonist Full agonist
[3H]AMPA None None
aniracetam Allosteric regulator Positive
LY293558 Antagonist Antagonist
(S)-5-fluorowillardiine Agonist Full agonist
cyclothiazide Allosteric regulator Positive
LY404187 Allosteric regulator Positive
IDRA-21 Allosteric regulator Positive
LY503430 Allosteric regulator Positive

(7) Novoseek inferred chemical compound relationships for GRIA4 Gene

Compound -log(P) Hits PubMed IDs
glutamate 75.8 18
kainate 73.4 6
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid 69.3 2
nmda 64.5 7
gaba 24.7 2
genes like me logo Genes that share compounds with GRIA4: view

Transcripts for GRIA4 Gene

Unigene Clusters for GRIA4 Gene

Glutamate receptor, ionotropic, AMPA 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRIA4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for GRIA4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIA4 Gene

No ASD Table

Relevant External Links for GRIA4 Gene

GeneLoc Exon Structure for
GRIA4
ECgene alternative splicing isoforms for
GRIA4

Expression for GRIA4 Gene

mRNA expression in normal human tissues for GRIA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIA4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (9.0), Brain - Cerebellum (7.4), Brain - Frontal Cortex (BA9) (5.2), and Brain - Anterior cingulate cortex (BA24) (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GRIA4 Gene

SOURCE GeneReport for Unigene cluster for GRIA4 Gene Hs.503743

genes like me logo Genes that share expressions with GRIA4: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GRIA4 Gene

Orthologs for GRIA4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GRIA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRIA4 35
  • 97.06 (n)
  • 97.01 (a)
GRIA4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GRIA4 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRIA4 35
  • 94.16 (n)
  • 99.45 (a)
GRIA4 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gria4 35
  • 90.91 (n)
  • 98.56 (a)
Gria4 16
Gria4 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRIA4 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRIA4 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gria4 35
  • 91.65 (n)
  • 98.45 (a)
chicken
(Gallus gallus)
Aves GRIA4 35
  • 89.17 (n)
  • 96.45 (a)
GRIA4 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRIA4 36
  • 91 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.13666 35
gria4a 36
  • 89 (a)
OneToMany
gria4b 36
  • 89 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4226 37
  • 28 (a)
CG15627 37
  • 27 (a)
Glu-RIIA 37
  • 32 (a)
Glu-RIB 37
  • 36 (a)
Glu-RI 37
  • 41 (a)
CG5621 37
  • 34 (a)
CG9935 37
  • 40 (a)
Kai-RIA 37
  • 34 (a)
CG11155 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea glr-1 37
  • 49 (a)
glr-4 37
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons GLR3.4 35
  • 40.86 (n)
  • 26.23 (a)
rice
(Oryza sativa)
Liliopsida Os06g0680500 35
  • 38.36 (n)
  • 22.54 (a)
Species with no ortholog for GRIA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GRIA4 Gene

ENSEMBL:
Gene Tree for GRIA4 (if available)
TreeFam:
Gene Tree for GRIA4 (if available)

Paralogs for GRIA4 Gene

Paralogs for GRIA4 Gene

genes like me logo Genes that share paralogs with GRIA4: view

Variants for GRIA4 Gene

Sequence variations from dbSNP and Humsavar for GRIA4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2372 -- 105,682,215(-) AAAAT(A/G)AAGAT intron-variant
rs3170 -- 105,642,334(-) AGGGA(A/T)TTCAA intron-variant
rs471396 -- 105,966,642(-) ATTTT(A/G)TTTTT intron-variant
rs471598 -- 105,953,504(-) TGCAT(G/T)GTCAG intron-variant
rs471795 -- 105,972,445(+) ATTAA(A/T)TAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRIA4 Gene

Variant ID Type Subtype PubMed ID
nsv472 CNV Insertion 18451855
nsv832256 CNV Gain 17160897
nsv898357 CNV Loss 21882294
nsv832257 CNV Loss 17160897
nsv39184 CNV Loss 16902084
esv2520318 CNV Deletion 19546169
esv2000018 CNV Deletion 18987734
esv2745021 CNV Deletion 23290073
esv9295 CNV Loss 19470904
esv2672300 CNV Deletion 23128226
esv2669612 CNV Deletion 23128226
esv2745022 CNV Deletion 23290073
esv2745023 CNV Deletion 23290073
esv4809 CNV Deletion 18987735
esv2658816 CNV Deletion 23128226
dgv23n6 CNV Loss 16902084
esv6086 CNV Loss 19470904
esv2599683 CNV Deletion 19546169
esv268793 CNV Insertion 20981092

Relevant External Links for GRIA4 Gene

HapMap Linkage Disequilibrium report
GRIA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIA4 Gene

Disorders for GRIA4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for GRIA4 Gene including...

Search for GRIA4 Gene in MalaCards »

(2) Novoseek inferred disease relationships for GRIA4 Gene

Disease -log(P) Hits PubMed IDs
epilepsy 5.88 1
schizophrenia 3.35 7

Relevant External Links for GRIA4

Genetic Association Database (GAD)
GRIA4
Human Genome Epidemiology (HuGE) Navigator
GRIA4
genes like me logo Genes that share disorders with GRIA4: view

No data available for UniProtKB/Swiss-Prot for GRIA4 Gene

Publications for GRIA4 Gene

  1. Positive association of the AMPA receptor subunit GluR4 gene (GRIA4) haplotype with schizophrenia: linkage disequilibrium mapping using SNPs evenly distributed across the gene region. (PMID: 12497607) Makino C. … Fukumaki Y. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003) 3 23 48
  2. No genetic association between polymorphisms in the AMPA receptor subunit GluR4 gene (GRIA4) and schizophrenia in the Chinese population. (PMID: 15450689) Guo S. … He L. (Neurosci. Lett. 2004) 3 23 48
  3. GluR4c, an alternative splicing isoform of GluR4, is abundantly expressed in the adult human brain. (PMID: 15306133) Kawahara Y. … Kwak S. (Brain Res. Mol. Brain Res. 2004) 3 23
  4. Characterization of the functional role of the N-glycans in the AMPA receptor ligand-binding domain. (PMID: 12603841) Pasternack A. … KeinAonen K. (J. Neurochem. 2003) 3 23
  5. Kinetic mechanism of channel opening of the GluRDflip AMPA receptor. (PMID: 15823042) Li G. … Niu L. (Biochemistry 2005) 3 23

Products for GRIA4 Gene

Sources for GRIA4 Gene

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