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Aliases for GRIA4 Gene

Aliases for GRIA4 Gene

  • Glutamate Ionotropic Receptor AMPA Type Subunit 4 2 3 5
  • Glutamate Receptor, Ionotrophic, AMPA 4 2 3
  • AMPA-Selective Glutamate Receptor 4 3 4
  • GluR-4 3 4
  • GluR-D 3 4
  • GLUR4 3 4
  • GluA4 3 4
  • Glutamate Receptor, Ionotropic, AMPA 4 3
  • Glutamate Receptor Ionotropic, AMPA 4 4
  • Glutamate Receptor 4 3
  • GLUR4C 3
  • GLURD 3

External Ids for GRIA4 Gene

Previous HGNC Symbols for GRIA4 Gene

  • GLUR4

Previous GeneCards Identifiers for GRIA4 Gene

  • GC11P107674
  • GC11P106838
  • GC11P105018
  • GC11P104986
  • GC11P101412

Summaries for GRIA4 Gene

Entrez Gene Summary for GRIA4 Gene

  • Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRIA4 Gene

GRIA4 (Glutamate Ionotropic Receptor AMPA Type Subunit 4) is a Protein Coding gene. Diseases associated with GRIA4 include Schizophrenia. Among its related pathways are Peptide ligand-binding receptors and Activation of NMDA receptor upon glutamate binding and postsynaptic events. GO annotations related to this gene include ionotropic glutamate receptor activity and AMPA glutamate receptor activity. An important paralog of this gene is GRIA3.

UniProtKB/Swiss-Prot for GRIA4 Gene

  • Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Tocris Summary for GRIA4 Gene

  • AMPA receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and kainate receptors. AMPA receptors mediate fast excitatory synaptic transmission and play a role in hippocampal synaptic long-term potentiation and depression.

Gene Wiki entry for GRIA4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIA4 Gene

Genomics for GRIA4 Gene

Regulatory Elements for GRIA4 Gene

Enhancers for GRIA4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around GRIA4 on UCSC Golden Path with GeneCards custom track

Promoters for GRIA4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for GRIA4 Gene

Chromosome:
11
Start:
105,609,994 bp from pter
End:
105,982,092 bp from pter
Size:
372,099 bases
Orientation:
Plus strand

Genomic View for GRIA4 Gene

Genes around GRIA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIA4 Gene

Proteins for GRIA4 Gene

  • Protein details for GRIA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48058-GRIA4_HUMAN
    Recommended name:
    Glutamate receptor 4
    Protein Accession:
    P48058
    Secondary Accessions:
    • Q86XE8

    Protein attributes for GRIA4 Gene

    Size:
    902 amino acids
    Molecular mass:
    100871 Da
    Quaternary structure:
    • Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with EPB41L1 via its C-terminus (By similarity). Found in a complex with GRIA1, GRIA2, GRIA3, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5 and PRKCG (By similarity).
    Miscellaneous:
    • The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.

    Alternative splice isoforms for GRIA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRIA4 Gene

Post-translational modifications for GRIA4 Gene

  • Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
  • Phosphorylated at Ser-862 by PRKCG; phosphorylation increases plasma membrane-associated GRI4 expression.
  • Glycosylation at Asn 56, Asn 258, Asn 371, Asn 407, and Asn 414
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GRIA4 Gene

Domains & Families for GRIA4 Gene

Gene Families for GRIA4 Gene

Suggested Antigen Peptide Sequences for GRIA4 Gene

Graphical View of Domain Structure for InterPro Entry

P48058

UniProtKB/Swiss-Prot:

GRIA4_HUMAN :
  • The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA4 subfamily.
Domain:
  • The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA4 subfamily.
genes like me logo Genes that share domains with GRIA4: view

Function for GRIA4 Gene

Molecular function for GRIA4 Gene

GENATLAS Biochemistry:
glutamate receptor,subunit 4,ionotropic,AMPA (amino-3-hydroxy 5 methyl-isoxazole-propionic) class,with flip and flop isoforms,mediating the fast component of excitatory post synaptic currents in the central nervous system,interacting with and signaling through the protein-kinase LYN
UniProtKB/Swiss-Prot Function:
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Gene Ontology (GO) - Molecular Function for GRIA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004970 ionotropic glutamate receptor activity ISS --
GO:0004971 AMPA glutamate receptor activity IDA 21172611
GO:0005231 excitatory extracellular ligand-gated ion channel activity TAS --
GO:0005234 extracellular-glutamate-gated ion channel activity IEA --
genes like me logo Genes that share ontologies with GRIA4: view
genes like me logo Genes that share phenotypes with GRIA4: view

Animal Models for GRIA4 Gene

MGI Knock Outs for GRIA4:

Animal Model Products

  • Taconic Biosciences Mouse Models for GRIA4

CRISPR Products

miRNA for GRIA4 Gene

miRTarBase miRNAs that target GRIA4

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRIA4 Gene

Localization for GRIA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIA4 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Interaction with CNIH2, CNIH3 and PRKCG promotes cell surface expression. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRIA4 Gene COMPARTMENTS Subcellular localization image for GRIA4 gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GRIA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0030054 cell junction IEA --
GO:0030425 dendrite IEA --
GO:0030666 endocytic vesicle membrane TAS --
GO:0032281 AMPA glutamate receptor complex ISS --
genes like me logo Genes that share ontologies with GRIA4: view

Pathways & Interactions for GRIA4 Gene

genes like me logo Genes that share pathways with GRIA4: view

SIGNOR curated interactions for GRIA4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GRIA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8589990
GO:0007215 glutamate receptor signaling pathway TAS 8589990
GO:0007268 chemical synaptic transmission TAS --
GO:0034220 ion transmembrane transport IEA --
GO:0035235 ionotropic glutamate receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GRIA4: view

Drugs & Compounds for GRIA4 Gene

(45) Drugs for GRIA4 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclothiazide Approved Pharma Positive, Allosteric regulator, inhibitor 0
Piracetam Approved Pharma Positive, Allosteric regulator 168
Ethanol Approved Pharma Target 1971
Perampanel Approved Pharma AMPA-type glutamate receptor antagonist 0
Aniracetam Experimental Pharma Positive, Allosteric regulator Nootropic drug for senile dementia 0

(3) Additional Compounds for GRIA4 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
dnqx
2379-57-9

(5) Tocris Compounds for GRIA4 Gene

Compound Action Cas Number
CNQX disodium salt Potent AMPA/kainate antagonist. More water soluble form of CNQX (Cat. No. 0190) 479347-85-8
DNQX Selective non-NMDA antagonist 2379-57-9
DNQX disodium salt Selective non-NMDA antagonist. Water-soluble salt of DNQX (Cat. No. 0189) 1312992-24-7
NBQX Potent AMPA antagonist. More selective than CNQX (Cat. No. 0190) 118876-58-7
NBQX disodium salt Potent AMPA antagonist. More water soluble form of NBQX (Cat. No. 0373) 479347-86-9

(8) ApexBio Compounds for GRIA4 Gene

Compound Action Cas Number
ADX-47273 851881-60-2
IEM 1754 dihydrobroMide 162831-31-4
Ifenprodil Tartrate NMDA receptor antagonist 23210-58-4
Latrepirdine Brain cell death inhibitor 97657-92-6
NMDA (N-Methyl-D-aspartic acid) NMDA receptor agonist 6384-92-5
VU 0361737 MGlu4 receptor allosteric modulator 1161205-04-4
VU 0364439 Positive allosteric mGluR-4 modulator 1246086-78-1
VU 0364770 61350-00-3
genes like me logo Genes that share compounds with GRIA4: view

Transcripts for GRIA4 Gene

Unigene Clusters for GRIA4 Gene

Glutamate receptor, ionotropic, AMPA 4:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIA4 Gene

No ASD Table

Relevant External Links for GRIA4 Gene

GeneLoc Exon Structure for
GRIA4
ECgene alternative splicing isoforms for
GRIA4

Expression for GRIA4 Gene

mRNA expression in normal human tissues for GRIA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIA4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x9.0), Brain - Cerebellum (x7.4), Brain - Frontal Cortex (BA9) (x5.2), and Brain - Anterior cingulate cortex (BA24) (x4.9).

Protein differential expression in normal tissues from HIPED for GRIA4 Gene

This gene is overexpressed in Vitreous humor (44.6), Cerebrospinal fluid (8.1), and Brain (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRIA4 Gene



Protein tissue co-expression partners for GRIA4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GRIA4 Gene:

GRIA4

SOURCE GeneReport for Unigene cluster for GRIA4 Gene:

Hs.503743
genes like me logo Genes that share expression patterns with GRIA4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GRIA4 Gene

Orthologs for GRIA4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GRIA4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia GRIA4 34
  • 94.16 (n)
  • 99.45 (a)
GRIA4 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gria4 34
  • 90.91 (n)
  • 98.56 (a)
Gria4 16
Gria4 35
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GRIA4 34
  • 97.06 (n)
  • 97.01 (a)
GRIA4 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gria4 34
  • 91.65 (n)
  • 98.45 (a)
cow
(Bos Taurus)
Mammalia GRIA4 35
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRIA4 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRIA4 35
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRIA4 34
  • 89.17 (n)
  • 96.45 (a)
GRIA4 35
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRIA4 35
  • 91 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.13666 34
gria4a 35
  • 89 (a)
OneToMany
gria4b 35
  • 89 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11155 36
  • 51 (a)
CG15627 36
  • 27 (a)
CG4226 36
  • 28 (a)
CG5621 36
  • 34 (a)
CG9935 36
  • 40 (a)
Glu-RI 36
  • 41 (a)
Glu-RIB 36
  • 36 (a)
Glu-RIIA 36
  • 32 (a)
Kai-RIA 36
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea glr-1 36
  • 49 (a)
glr-4 36
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons GLR3.4 34
  • 40.86 (n)
  • 26.23 (a)
rice
(Oryza sativa)
Liliopsida Os06g0680500 34
  • 38.36 (n)
  • 22.54 (a)
Species where no ortholog for GRIA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GRIA4 Gene

ENSEMBL:
Gene Tree for GRIA4 (if available)
TreeFam:
Gene Tree for GRIA4 (if available)

Paralogs for GRIA4 Gene

Paralogs for GRIA4 Gene

genes like me logo Genes that share paralogs with GRIA4: view

Variants for GRIA4 Gene

Sequence variations from dbSNP and Humsavar for GRIA4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs994575 -- 105,694,740(+) GTTTT(C/G)TCATA intron-variant
rs1002191 -- 105,821,326(-) ATACC(C/G)CCTCC intron-variant
rs1037089 -- 105,679,276(-) GTGGA(C/T)TCTGA intron-variant
rs1037090 -- 105,679,008(-) AATAC(A/G)TCTAC intron-variant
rs1144410 -- 105,909,399(-) AATGC(G/T)TGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRIA4 Gene

Variant ID Type Subtype PubMed ID
dgv23n6 CNV deletion 16902084
esv2000018 CNV deletion 18987734
esv2520318 CNV deletion 19546169
esv2599683 CNV deletion 19546169
esv2658816 CNV deletion 23128226
esv2669612 CNV deletion 23128226
esv2672300 CNV deletion 23128226
esv2745021 CNV deletion 23290073
esv2745022 CNV deletion 23290073
esv2745023 CNV deletion 23290073
esv3304515 CNV mobile element insertion 20981092
esv3417415 CNV insertion 20981092
esv3548298 CNV deletion 23714750
esv3548302 CNV deletion 23714750
esv3579896 CNV loss 25503493
esv3627616 CNV loss 21293372
esv3627617 CNV loss 21293372
esv3627619 CNV loss 21293372
esv3627620 CNV loss 21293372
esv3892096 CNV gain 25118596
esv4809 CNV loss 18987735
esv6086 CNV loss 19470904
esv9295 CNV loss 19470904
nsv1052674 CNV loss 25217958
nsv1053687 CNV loss 25217958
nsv1075434 CNV duplication 25765185
nsv1075839 CNV duplication 25765185
nsv1134173 CNV deletion 24896259
nsv1144590 CNV deletion 24896259
nsv39184 CNV deletion 16902084
nsv472 CNV insertion 18451855
nsv832256 CNV gain 17160897
nsv832257 CNV loss 17160897

Variation tolerance for GRIA4 Gene

Residual Variation Intolerance Score: 3.06% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRIA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRIA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIA4 Gene

Disorders for GRIA4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GRIA4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search GRIA4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GRIA4

Genetic Association Database (GAD)
GRIA4
Human Genome Epidemiology (HuGE) Navigator
GRIA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRIA4
genes like me logo Genes that share disorders with GRIA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRIA4 Gene

Publications for GRIA4 Gene

  1. No genetic association between polymorphisms in the AMPA receptor subunit GluR4 gene (GRIA4) and schizophrenia in the Chinese population. (PMID: 15450689) Guo S. … He L. (Neurosci. Lett. 2004) 3 22 46 65
  2. Positive association of the AMPA receptor subunit GluR4 gene (GRIA4) haplotype with schizophrenia: linkage disequilibrium mapping using SNPs evenly distributed across the gene region. (PMID: 12497607) Makino C. … Fukumaki Y. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003) 3 22 46 65
  3. Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. (PMID: 21172611) Kato A.S. … Bredt D.S. (Neuron 2010) 3 4 65
  4. Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study. (PMID: 18521090) Lavedan C. … Polymeropoulos M.H. (Mol. Psychiatry 2009) 3 46 65
  5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 46 65

Products for GRIA4 Gene

Sources for GRIA4 Gene

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