Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GRIA4 Gene

protein-coding   GIFtS: 65
GCID: GC11P105514

Glutamate Receptor, Ionotropic, AMPA 4

(Previous names: glutamate receptor, ionotrophic, AMPA 4)
(Previous symbol: GLUR4)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Glutamate Receptor, Ionotropic, AMPA 41 2     gluR-42
GLUR41 2 3 5     gluR-D2
Glutamate Receptor, Ionotrophic, AMPA 41 2     Glutamate Receptor 42
GluA42 3     GluR-43
AMPA-Selective Glutamate Receptor 42 3     GluR-D3
GLUR4C2     GluR43
GLURD2     Glutamate Receptor Ionotropic, AMPA 43

External Ids:    HGNC: 45741   Entrez Gene: 28932   Ensembl: ENSG000001525787   OMIM: 1382465   UniProtKB: P480583   

Export aliases for GRIA4 gene to outside databases

Previous GC identifers: GC11P107674 GC11P106838 GC11P105018 GC11P104986 GC11P101412


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GRIA4 Gene:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are
activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes
composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate
receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene
belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate
receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in
transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some
haplotypes of this gene show a positive association with schizophrenia. (provided by RefSeq, Jul 2008)

GeneCards Summary for GRIA4 Gene:
GRIA4 (glutamate receptor, ionotropic, AMPA 4) is a protein-coding gene. Diseases associated with GRIA4 include drug addiction, and nicotine addiction. GO annotations related to this gene include ionotropic glutamate receptor activity and extracellular-glutamate-gated ion channel activity. An important paralog of this gene is GRIA3.

UniProtKB/Swiss-Prot: GRIA4_HUMAN, P48058
Function: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and
plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter
at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a
conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an
electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized
by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is
characterized by a delayed accumulation of current flux upon continued application of glutamate

summary for GRIA4 Gene:
AMPA receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and
kainate receptors. AMPA receptors mediate fast excitatory synaptic transmission in the CNS and play a key
role in hippocampal synaptic long-term potentiation (LTP) and depression (LTD). AMPA receptors consist of
GluR1-4 subunits which assemble as homomers or heteromers to form functional AMPA receptors. The subunit
composition determines the physiological properties of AMPA receptors: those containing the GluR2 subunit
show low permeability to Ca2+ whereas those lacking this subunit show high Ca2+ permeability.

Gene Wiki entry for GRIA4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000011.10  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GRIA4 gene promoter:
         FOXI1   AREB6   FOXO4   NF-E2   NF-E2 p45   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRIA4 promoter sequence
   Search Chromatin IP Primers for GRIA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRIA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22

GRIA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRIA4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P105514:  view genomic region     (about GC identifiers)

Start:
105,480,721 bp from pter      End:
105,852,819 bp from pter
Size:
372,099 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GRIA4_HUMAN, P48058 (See protein sequence)
Recommended Name: Glutamate receptor 4 precursor  
Size: 902 amino acids; 100871 Da
Subunit: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by
the dimerization of dimers. Interacts with EPB41L1 via its C-terminus (By similarity). Found in a complex with
GRIA1, GRIA2, GRIA3, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5 and
PRKCG (By similarity)
Miscellaneous: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to
their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate
Secondary accessions: Q86XE8
Alternative splicing: 2 isoforms:  P48058-1   P48058-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GRIA4: NX_P48058

Explore proteomics data for GRIA4 at MOPED

Post-translational modifications: 

  • Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and
    decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression
    but regulates stimulation-dependent endocytosis (By similarity)1
  • Phosphorylated at Ser-862 by PRKCG; phosphorylation increases plasma membrane-associated GRI4 expression (By
    similarity)1
  • Glycosylation2 at Asn56, Asn258, Asn371, Asn407, Asn414
  • Modification sites at PhosphoSitePlus

  • See GRIA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_000820.3  NP_001070711.2  NP_001070712.1  NP_001106283.1  

    ENSEMBL proteins: 
     ENSP00000436449   ENSP00000376833   ENSP00000436143   ENSP00000432371   ENSP00000433621  
     ENSP00000415551   ENSP00000432443   ENSP00000432180   ENSP00000435775   ENSP00000433873  
     ENSP00000282499   ENSP00000376835  
    Reactome Protein details: P48058

    GRIA4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GRIA4
    GenScript Custom Purified and Recombinant Proteins Services for GRIA4
    Novus Biologicals GRIA4 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GRIA4

    GRIA4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GRIA4
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for GRIA4  (GluR4)
    OriGene Antibodies for GRIA4
    OriGene Custom Antibody Services for GRIA4
    Novus Biologicals GRIA4 Antibodies
    Abcam antibodies for GRIA4
    Cloud-Clone Corp. Antibodies for GRIA4
    ThermoFisher Antibodies for GRIA4
    LSBio Antibodies in human, mouse, rat for GRIA4

    GRIA4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GRIA4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GRIA4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GRIA4
    Cloud-Clone Corp. CLIAs for GRIA4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    GRI: Ligand-gated ion channels / Glutamate receptors, ionotropic
    GR: Glutamate receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GluA4
    Ionotropic glutamate receptors

    5 InterPro protein domains:
     IPR028082 Peripla_BP_I
     IPR019594 Glu_rcpt_Glu/Gly-bd
     IPR001320 Iontro_glu_rcpt
     IPR001828 ANF_lig-bd_rcpt
     IPR001508 NMDA_rcpt

    Graphical View of Domain Structure for InterPro Entry P48058

    ProtoNet protein and cluster: P48058

    3 Blocks protein domains:
    IPB001320 Ionotropic glutamate receptor
    IPB001508 NMDA receptor signature
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GRIA4_HUMAN, P48058
    Domain: The M4 transmembrane segment mediates tetramerization and is required for cell surface expression (By
    similarity)
    Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA4 subfamily


    GRIA4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRIA4_HUMAN, P48058
    Function: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and
    plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter
    at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a
    conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an
    electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized
    by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is
    characterized by a delayed accumulation of current flux upon continued application of glutamate

         Genatlas biochemistry entry for GRIA4:
    glutamate receptor,subunit 4,ionotropic,AMPA (amino-3-hydroxy 5 methyl-isoxazole-propionic) class,with flip and
    flop isoforms,mediating the fast component of excitatory post synaptic currents in the central nervous
    system,interacting with and signaling through the protein-kinase LYN

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004970ionotropic glutamate receptor activity ISS--
    GO:0004971alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity IDA--
    GO:0005215transporter activity ----
    GO:0005234extracellular-glutamate-gated ion channel activity IBA--
    GO:0005515protein binding ----
         
    GRIA4 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Gria4):
     behavior/neurological  growth/size/body  homeostasis/metabolism  integument  nervous system 
     no phenotypic analysis 

    GRIA4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GRIA4: Gria4tm1Rlh Gria4tm1Ksak Gria4tm1Dgen Gria4tm1.1Mony Gria4tm1Yfkk Gria4tm2.1Rlh

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRIA4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GRIA4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRIA4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GRIA4

    miRNA
    Products:
        
    miRTarBase miRNAs that target GRIA4:
    hsa-mir-484 (MIRT042105)

    Block miRNA regulation of human, mouse, rat GRIA4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GRIA4 (see all 92):
    hsa-miR-4272 hsa-miR-128 hsa-miR-1258 hsa-miR-3074-3p hsa-miR-578 hsa-miR-4275 hsa-miR-1244 hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmidGRIA4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GRIA4
    Predesigned siRNA for gene silencing in human, mouse, rat GRIA4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GRIA4

    Clone
    Products:
         
    OriGene clones in human, mouse for GRIA4 (see all 24)
    OriGene ORF clones in mouse, rat for GRIA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): GRIA4 (NM_000829)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRIA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRIA4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GRIA4
    Browse ESI BIO Cell Lines and PureStem Progenitors for GRIA4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIA4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GRIA4_HUMAN, P48058: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell
    membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Interaction with CNIH2, CNIH3 and PRKCG
    promotes cell surface expression (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0030054cell junction IEA--
    GO:0030425dendrite IBA--

    GRIA4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GRIA4 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Trafficking of AMPA receptors
    Trafficking of AMPA receptors1.00
    Trafficking of GluR2-containing AMPA receptors0.00
    Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity1.00
    Activation of AMPA receptors0.00
    2Circadian entrainment
    Retrograde endocannabinoid signaling0.51
    Glutamatergic synapse0.39
    Circadian entrainment0.40
    Dopaminergic synapse0.37
    3Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    4Post NMDA receptor activation events
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.90
    Unblocking of NMDA receptor, glutamate binding and activation0.00
    5CREB Pathway
    CREB Pathway0.68
    Intracellular Calcium Signaling0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GRIA4
        Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Pathogenesis of ALS
    CREB Pathway
    Intracellular Calcium Signaling
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    1 Cell Signaling Technology (CST) Pathway for GRIA4
        Neuroscience

    1 GeneGo (Thomson Reuters) Pathway for GRIA4
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    1 BioSystems Pathway for GRIA4
        Hypothetical Network for Drug Addiction

    4 Reactome Pathways for GRIA4
        Unblocking of NMDA receptor, glutamate binding and activation
    Trafficking of AMPA receptors
    Trafficking of GluR2-containing AMPA receptors
    Activation of AMPA receptors


    Selected Kegg Pathways  (Kegg details for GRIA4) (see all 7):
        Neuroactive ligand-receptor interaction
    Circadian entrainment
    Retrograde endocannabinoid signaling
    Glutamatergic synapse
    Dopaminergic synapse


    GRIA4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRIA4: 
              GABA & Glutamate in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GRIA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GRIA4 (P480582, 3 ENSP000002824994) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKACAP176122, 3, ENSP000003095914MINT-13729 MINT-49874 I2D: score=2 STRING: ENSP00000309591
    CAMK2AQ9UQM72, 3, ENSP000003814124MINT-17826 I2D: score=1 STRING: ENSP00000381412
    SDCBPO005603, ENSP000002601304I2D: score=3 STRING: ENSP00000260130
    GRIA2P422623, ENSP000002644264I2D: score=2 STRING: ENSP00000264426
    PRKCGP051293, ENSP000002634314I2D: score=2 STRING: ENSP00000263431
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS8589990
    GO:0007215glutamate receptor signaling pathway TAS8589990
    GO:0007268synaptic transmission TAS--
    GO:0034220ion transmembrane transport IBA--
    GO:0035235ionotropic glutamate receptor signaling pathway ISS--

    GRIA4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GRIA4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CNQX disodium saltPotent AMPA/kainate antagonist. More water soluble form of CNQX (Cat. No. 0190)[115066-14-3]
    Naspm trihydrochlorideCa2+-permeable AMPA receptor antagonist[122306-11-0]
    NBQXPotent AMPA antagonist. More selective than CNQX (Cat. No. 0190)[118876-58-7]
    DNQX disodium saltSelective non-NMDA antagonist. Water-soluble salt of DNQX (Cat. No. 0189)[2379-57-9]
    NBQX disodium saltPotent AMPA antagonist. More water soluble form of NBQX (Cat. No. 0373)[118876-58-7]

    1 DrugBank Compound for GRIA4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--7679210 12008069 17139284 11406192 17016423

    Selected IUPHAR Ligands for GRIA4 (GluA4) (see all 21)    About this table
    LigandTypeActionAffinityPubmed IDs
    S18986
    Allosteric regulatorPositive--
    LY392098
    Allosteric regulatorPositive--
    CX546
    Allosteric regulatorPositive--
    CX516
    Allosteric regulatorPositive--
    argiotoxin
    Channel blockerNone--
    joro toxin
    Channel blockerNone--
    piracetam
    Allosteric regulatorPositive--
    [3H]CNQX
    NoneNone--
    ATPO
    AntagonistAntagonist--
    GYKI53655
    AntagonistAntagonist--

    7 Novoseek inferred chemical compound relationships for GRIA4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 75.8 22 15255946 (2), 15634782 (1), 9437035 (1), 8873866 (1) (see all 17)
    kainate 73.4 8 10448859 (1), 12008069 (1), 15255946 (1), 18087239 (1) (see all 6)
    alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid 69.3 2 17432955 (1), 9388556 (1)
    nmda 64.5 10 9538905 (2), 7504083 (1), 10448859 (1), 17924980 (1) (see all 6)
    gaba 24.7 2 19492025 (1), 10235640 (1)
    calcium 0.301 2 12008069 (1), 17432955 (1)
    dopamine 0.14 1 15255946 (1)



    GRIA4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GRIA4 gene (4 alternative transcripts): 
    NM_000829.3  NM_001077243.2  NM_001077244.1  NM_001112812.1  

    Unigene Cluster for GRIA4:

    Glutamate receptor, ionotropic, AMPA 4
    Hs.503743  [show with all ESTs]
    Unigene Representative Sequence: NM_001077243
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527177 ENST00000393125(uc001piu.1) ENST00000531986 ENST00000527669(uc001pit.3)
    ENST00000525921 ENST00000525032(uc001piv.3) ENST00000428631(uc009yxk.1)
    ENST00000531011 ENST00000525187 ENST00000530497 ENST00000527687 ENST00000525942(uc010rvm.1)
    ENST00000533094 ENST00000282499(uc001pix.2) ENST00000393127(uc001piw.2 uc009yxl.1)


    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GRIA4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GRIA4 (see all 92):
    hsa-miR-4272 hsa-miR-128 hsa-miR-1258 hsa-miR-3074-3p hsa-miR-578 hsa-miR-4275 hsa-miR-1244 hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmidGRIA4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GRIA4
    Predesigned siRNA for gene silencing in human, mouse, rat GRIA4
    Clone
    Products:
         
    OriGene clones in human, mouse for GRIA4 (see all 24)
    OriGene ORF clones in mouse, rat for GRIA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): GRIA4 (NM_000829)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRIA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRIA4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GRIA4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GRIA4
      QuantiTect SYBR Green Assays in human, mouse, rat GRIA4
      QuantiFast Probe-based Assays in human, mouse, rat GRIA4

    Additional mRNA sequence: 

    AB115416.1 AB209092.1 AK311193.1 BC015199.1 BC035610.1 BC045546.1 BC114549.1 BC142654.1 
    BC146816.1 BC150209.1 FJ947075.1 FJ947076.1 JN547407.1 NR_046356.1 U16129.1 

    10 DOTS entries:

    DT.210648  DT.101969850  DT.40194019  DT.102825266  DT.40111045  DT.106431  DT.92020336  DT.120760481 
    DT.97822773  DT.40130672 

    Selected AceView cDNA sequences (see all 40):

    BC045546 CA398023 BM726613 AL134656 H46078 BM681259 AW295058 BX431201 
    BQ717001 CA398022 BM665840 N52193 AL133882 BI757498 U16129 BF796432 
    CK004407 NM_000829 BC015199 R93820 BM661705 BX433110 BM715126 BM548364 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GRIA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTCCCCC
    GRIA4 Expression
    About this image


    GRIA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Mesonephric cells Mesonephros
             Mesonephros
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephros
     
     Eye (Sensory Organs)
             Retina
     
     Testis (Reproductive System)
             Vas Deferens
     
     Gonad
             Mesonephric cells Mesonephros
    GRIA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GRIA4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.503743
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRIA4: 
              GABA & Glutamate in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for GRIA4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GRIA4
    QuantiTect SYBR Green Assays in human, mouse, rat GRIA4
    QuantiFast Probe-based Assays in human, mouse, rat GRIA4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GRIA4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gria41 , 5 glutamate receptor, ionotropic, AMPA4 (alpha 4)1, 5 90.91(n)1
    98.56(a)1
      9 (2.46 cM)5
    148021  NM_001113180.11  NP_001106651.11 
     44178995 
    chicken
    (Gallus gallus)
    Aves GRIA41 glutamate receptor, ionotropic, AMPA 4 89.17(n)
    96.45(a)
      396137  NM_001113186.1  NP_001106657.1 
    lizard
    (Anolis carolinensis)
    Reptilia GRIA46
    glutamate receptor, ionotropic, AMPA 4
    91(a)
    1 ↔ 1
    3(190375530-190707840)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.136662 Danio rerio AMPA receptor subunit GluR4A (glur4a) mRNA, more 77.8(n)    AF525747.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GLR3.41 GLR3.4 40.86(n)
    26.23(a)
      839268  NM_100398.2  NP_172012.2 
    rice
    (Oryza sativa)
    Liliopsida Os06g06805001 Os06g0680500 38.36(n)
    22.54(a)
      4341854  NM_001064907.1  NP_001058372.1 


    ENSEMBL Gene Tree for GRIA4 (if available)
    TreeFam Gene Tree for GRIA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GRIA4 gene
    GRIA32  GRIK52  GRIK12  GRIA22  GRIK22  GRID12  GRIA12  GRIK32  
    GRIK42  GRID22  
    11 SIMAP similar genes for GRIA4 using alignment to 10 protein entries:     GRIA4_HUMAN (see all proteins):
    GluR4c    GRIA1    GRIA2    GRIA3    GRIK2    GRIK1
    GRIK3    GRIK5    GRIK4    GRID2    GRID1

    GRIA4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GRIA4 (see all 6574)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1908609621,2
    Cuntested1105517565(+) AAAACC/TCTGGA 5 -- int10--------
    rs563141661,2
    C--101431261(+) AAATA-/AATAAATA/AA
    TAAATAAATAAATA
    GAGAC
    5 -- int11NA 2
    rs1889265651,2
    --105478832(+) AACTAC/TTTGAC 3 -- us2k10--------
    rs1498582961,2
    --105478866(+) TATATA/TCGTAT 3 -- us2k10--------
    rs1812983801,2
    --105478918(+) AAAATA/GTATTT 3 -- us2k10--------
    rs1475281761,2
    --105479006(+) TAACTA/GCTTGG 3 -- us2k10--------
    rs1401203261,2
    --105479090(+) CCAGGC/TGTTAT 3 -- us2k10--------
    rs1839833311,2
    --105479151(+) TGCTAC/TTACAT 3 -- us2k10--------
    rs1884655481,2
    --105479168(+) AAAACC/TGAAAT 3 -- us2k10--------
    rs1455322811,2
    --105479203(+) GTTAAC/TAATTG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for GRIA4 (105480721 - 105730721 bp, first 250kb of GRIA4)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GRIA4 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672300CNV Deletion23128226
    esv2599683CNV Deletion19546169
    esv2669612CNV Deletion23128226
    esv2658816CNV Deletion23128226
    esv2000018CNV Deletion18987734
    esv2745021CNV Deletion23290073
    esv2520318CNV Deletion19546169
    esv2745023CNV Deletion23290073
    esv4809CNV Deletion18987735
    esv2745022CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GRIA4
    DNA2.0 Custom Variant and Variant Library Synthesis for GRIA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 138246    OMIM disorders: --

    18 diseases for GRIA4:    
    About MalaCards
    drug addiction    nicotine addiction    schizophrenia    refractive error
    major depressive disorder    myopia    lateral sclerosis    amyotrophic lateral sclerosis
    bipolar disorder    huntington's disease    ischemia    parkinson's disease
    multiple sclerosis    cerebritis    retinitis    cervicitis
    neuronitis    endotheliitis


    GRIA4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for GRIA4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    epilepsy 5.88 1 9455976 (1)
    schizophrenia 3.35 8 15450689 (4), 12497607 (3)

    Genetic Association Database (GAD): GRIA4
    Human Genome Epidemiology (HuGE) Navigator: GRIA4 (9 documents)

    Export disorders for GRIA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GRIA4 gene, integrated from 10 sources (see all 105):
    (articles sorted by number of sources associating them with GRIA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. No genetic association between polymorphisms in the AMPA receptor subunit GluR4 gene (GRIA4) and schizophrenia in the Chinese population. (PubMed id 15450689)1, 4, 9 Guo S....He L. (Neurosci. Lett. 2004)
    2. Positive association of the AMPA receptor subunit GluR4 gene (GRIA4) haplotype with schizophrenia: linkage disequilibrium mapping using SNPs evenly distributed across the gene region. (PubMed id 12497607)1, 4, 9 Makino C....Fukumaki Y. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003)
    3. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    4. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    5. Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study. (PubMed id 18521090)1, 4 Lavedan C....Polymeropoulos M.H. (Mol. Psychiatry 2009)
    6. Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia. (PubMed id 19125103)1, 4 Arai S....Fukumaki Y. (Psychiatr. Genet. 2009)
    7. Applicability of a genetic signature for enhanced iloperidone efficacy in the treatment of schizophrenia. (PubMed id 19573479)1, 4 Volpi S....Lavedan C. (J Clin Psychiatry 2009)
    8. Study on GRIA2, GRIA3 and GRIA4 genes highlights a positive association between schizophrenia and GRIA3 in female patients. (PubMed id 18163426)1, 4 Magri C....Barlati S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    9. Cloning, expression and pharmacological characterization of a human glutamate receptor: hGluR4. (PubMed id 8589990)1, 2 Fletcher E.J.... Kamboj R.K. (Recept. Channels 1995)
    10. PKC anchoring to GluR4 AMPA receptor subunit modulates PKC-driven receptor phosphorylation and surface expression. (PubMed id 17233759)1, 9 Gomes A.R....Carvalho A.L. (Traffic 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2893 HGNC: 4574 AceView: GRIA4 Ensembl:ENSG00000152578 euGenes: HUgn2893
    ECgene: GRIA4 Kegg: 2893 H-InvDB: GRIA4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GRIA4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GRIA4 gene:
    Search GeneIP for patents involving GRIA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of GRIA4
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GRIA4   OriGene RNAi products in human, mouse, rat for GRIA4  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GRIA4  
     OriGene qSTAR qPCR primer pairs in human, mouse for GRIA4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GRIA4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GRIA4   OriGene Custom Protein Services for GRIA4  

     
     
     Block miRNA regulation of human, mouse, rat GRIA4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GRIA4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRIA4 Predesigned siRNA for gene silencing in human, mouse, rat GRIA4
     QuantiFast Probe-based Assays in human, mouse, rat GRIA4 QuantiTect SYBR Green Assays in human, mouse, rat GRIA4
     PCR Arrays including human, mouse, rat GRIA4 Search Chromatin IP Primers for GRIA4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GRIA4  GeneGlobe Interaction Network for GRIA4
     Regulatory tfbs in GRIA4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for GRIA4 GenScript cDNA clones with any tag delivered in your preferred vector for GRIA4
     GenScript Custom Assay Services for GRIA4 GenScript Custom overexpressing Cell Line Services for GRIA4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for GRIA4  (GluR4)

     Tocris compounds for GRIA4
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GRIA4 antibodies
     GRIA4 proteins
     Antibodies for GRIA4
     See all of Abcam's Antibodies, Kits and Proteins for GRIA4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for GRIA4
     Antibodies for GRIA4
     ELISAs for GRIA4
     CLIAs for GRIA4



     Browse ESI BIO Cell Lines and PureStem Progenitors for GRIA4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIA4
     SwitchGear 3'UTR luciferase reporter plasmids for GRIA4
     SwitchGear Promoter luciferase reporter plasmids for GRIA4
     ThermoFisher Antibodies for GRIA4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRIA4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRIA4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GRIA4
     LSBio Antibodies in human, mouse, rat for GRIA4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GRIA4 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4