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GRIA3 Gene

protein-coding GIFtS: 71

GC0XP122145

glutamate receptor, ionotrophic, AMPA 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GLUR3)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
GLUR-C ^²
GLUR-K3 ^²
GLUR3 ^², ³, ⁵
GLURC ^¹, ², ³
GluR-3 ^³
GluR-C ^³
GluR-K3 ^³
MRX94 ^², ⁵
OTTHUMP00000024261 ^²
OTTHUMP00000024262 ^²
dJ1171F9.1 ^²

Descriptions
AMPA-selective glutamate receptor 3 ^³
Glutamate receptor ionotropic, AMPA 3 ^³
glutamate receptor C ^²
glutamate receptor subunit 3 ^²
glutamate receptor, ionotrophic, AMPA 3 ^²

External Ids
HGNC: 4573¹
Entrez Gene: 2892²
UniProtKB: P42263³
Ensembl: ENSG00000125675⁷

Search outside databases for aliases for GRIA3 gene

Previous GC identifers: GC0XP117035 GC0XP119211 GC0XP120270 GC0XP121015 GC0XP122044

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for GRIA3:

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian

brain and are activated in a variety of normal neurophysiologic processes. These receptors are

heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion

channels. The classification of glutamate receptors is based on their activation by different

pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA

(alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is

subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in

different isoforms, which may vary in their signal transduction properties. [provided by RefSeq]

UniProtKB/Swiss-Prot: GRIA3_HUMAN, P42263

Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many

synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate

induces a conformation change, leading to the opening of the cation channel, and thereby converts

the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a

transient inactive state, characterized by the presence of bound agonist

Gene Wiki entry for GRIA3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GRIA3 gene

Entrez Gene cytogenetic band: Xq25-q26 Ensembl cytogenetic band: Xq25 HGNC cytogenetic band: Xq25

GRIA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP122145: (about GC identifiers)

Start:	122,145,687 bp from pter
End:	122,452,447 bp from pter
Size:	306,761 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_011786.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GRIA3_HUMAN, P42263 (See protein sequence)

Recommended Name: Glutamate receptor 3 precursor

Size: 894 amino acids; 101157 Da

Subunit: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may

be formed by the dimerization of dimers. Interacts with PRKCABP, GRIP1 and GRIP2 (By similarity)

Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse,

postsynaptic cell membrane; Multi-pass membrane protein

Miscellaneous: The postsynaptic actions of Glu are mediated by a variety of receptors that are

named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate >

kainate

Caution: It is uncertain whether Met-1 or Met-7 is the initiator

Secondary accessions: Q4VXD5 Q4VXD6 Q9HDA0 Q9HDA1 Q9HDA2

Alternative splicing: 2 isoforms: P42263-1 P42263-2

Post-translational modifications:

Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-621 palmitoylation leads to Golgi

retention and decreased cell surface expression. In contrast, Cys-847 palmitoylation does not

affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_000819.3 NP_015564.4

ENSEMBL proteins:

ENSP00000264357 ENSP00000335428 ENSP00000360313 ENSP00000360297 ENSP00000360311 ENSP00000360302

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Ionotropic glutamate receptor 2 + 3, Glutamate receptor 3)
	Human Recombinant Proteins from Abnova (GRIA3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	1709304
GO:0016021	integral to membrane	IEA	--
GO:0030054	cell junction	IEA	--
GO:0045202	synapse	IEA	--
GO:0045211	postsynaptic membrane	IEA	--

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Antibodies for GRIA3:

	Invitrogen Antibodies for GRIA3
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for GRIA3 (GluR3)
	Cell Signaling Technology (CST) Antibodies for GRIA3 (GluR3)
	Antibodies from Abcam (Ionotropic glutamate receptor 2 + 3, Glutamate receptor 3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GRIA3)
	Novus Biologicals Antibodies for GRIA3

Assays for GRIA3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P42263

ProtoNet protein and cluster: P42263

3 Blocks protein families:

IPB001320 Ionotropic glutamate receptor

IPB001508 NMDA receptor signature

IPB001828 Extracellular ligand-binding receptor

UniProtKB/Swiss-Prot: GRIA3_HUMAN, P42263

Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GRIA3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_000828

Applied Biosystems Silencer® siRNAs for GRIA3

Sigma-Aldrich siRNA and siRNA Panels for GRIA3

Sigma-Aldrich shRNA for GRIA3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000828
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000828
untagged cDNA clones in CMV expression vector (see all 5): BC032004

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_007325

UniProtKB/Swiss-Prot: GRIA3_HUMAN, P42263

Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many

synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate

induces a conformation change, leading to the opening of the cation channel, and thereby converts

the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a

transient inactive state, characterized by the presence of bound agonist

Genatlas biochemistry entry for GRIA3:

glutamate receptor,subunit 3,ionotropic,AMPA (amino-3-hydroxy 5 methyl-isoxazole-propionic)

class,with flip and flop isoforms,mediating the fast component of excitatory post synaptic

currents in the central nervous system,interacting with and signaling through the protein-kinase

LYN

9 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Gria3):

behavior/neurological	growth/size	hearing/vestibular/ear	homeostasis/metabolism	lethality-postnatal
nervous system	no phenotypic analysis	reproductive system	touch/vibrissae

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004970	ionotropic glutamate receptor activity	IEA	--
GO:0005216	ion channel activity	IEA	--
GO:0005234	extracellular-glutamate-gated ion channel activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for GRIA3 (Your Favorite Gene powered by Ingenuity) (see all 7 )

Calcium Signaling
Synaptic Long Term Depression
Synaptic Long Term Potentiation
Glutamate Receptor Signaling
Neuropathic Pain Signaling In Dorsal Horn Neurons

GeneDecks GRIA3 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for GRIA3

5/14 Interacting proteins for GRIA3 (ENSP00000360302³) via UniProtKB, MINT, and/or STRING (see all 14 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PICK1	ENSP00000349465³	STRING (score=.982)
GRIA2	ENSP00000264426³	STRING (score=.973)
GRIP1	ENSP00000352780³	STRING (score=.946)
CACNG2	ENSP00000300105³	STRING (score=.882)
DLG4	ENSP00000293813³	STRING (score=.878)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0007215	glutamate signaling pathway	TAS	1709304

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for GRIA3

Sigma-Aldrich Small Molecules for GRIA3:

Antagonist Blocker Allosteric Modulator Agonist

Compounds for GRIA3 available from Tocris Bioscience

Compound	Action	CAS number
(S)-AMPA	Selective AMPA agonist. Active isomer of (RS)-AMPA (Cat. No. 0169)	[83643-88-3]
CP 465022 hydrochloride	Selective, non-competitive AMPA antagonist	[199655-36-2]
A 769662	Potent AMPK activator	[844499-71-4]
GYKI 52466 hydrochloride	Selective non-competitive AMPA antagonist	[102771-26-6]
NBQX disodium salt	More water soluble form of NBQX (Cat. No. 0373)	[118876-58-7]

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3 Novoseek chemical compound relationships for GRIA3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium	26.82	10	9106453 (3), 1372254 (2), 16344514 (1), 1709304 (1) (see all 6)
magnesium	0.00	1	9106453 (1)
zinc	0.00	11	8015375 (6), 9106453 (3)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GRIA3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_000828

Sigma-Aldrich siRNA and siRNA Panels for GRIA3

Sigma-Aldrich shRNA for GRIA3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000828 NM_007325

REFSEQ mRNAs for GRIA3 gene (2 alternative transcripts):

NM_000828.4 NM_007325.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000828 NM_007325

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000828
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000828
                                 untagged cDNA clones in CMV expression vector (see all 5): BC032004

Additional cDNA sequence:

AK297136.1 BC032004.1 BC117464.1 U10301.1 U10302.1

11 DOTS entries:

DT.456066 DT.442710 DT.65288259 DT.121322982 DT.75138177 DT.121322946 DT.97804511 DT.121322980

DT.121322984 DT.65288776 DT.91744130

24/86 AceView cDNA sequences (see all 86 ):

NM_007325 AW166130 BQ416790 BM683403 AW166119 AI680688 AW207024 NM_000828

BE220607 Z40626 AI358903 BE503011 AI160594 AV708569 BX119058 BF110551

BE220304 BX109400 AW875738 BX506894 BG680842 AI589333 BX954052 AI379066

highest scoring ESTs for GRIA3:

U10301 AI680688 BE669805 AI379066 AI589333 AL712243 AL712867 AW373375 AW875738 AW875741

Unigene Cluster for GRIA3:

Glutamate receptor, ionotrophic, AMPA 3

Hs.377070 [show with all ESTs]

Unigene Representative Sequence: NM_000828

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for GRIA3

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19
SP1:									-				-		-						-																						-
SP2:									-				-		-						-																								-
SP3:									-
SP4:													-		-
SP5:									-				-		-

About this scheme

ECgene alternative splicing isoforms for GRIA3

6 Ensembl transcripts including schematic representations:

ENST00000264357 ENST00000335161 ENST00000371266 ENST00000371251 ENST00000371264 ENST00000371256

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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GRIA3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GRIA3

¹ / ² / ³

11 probe-sets matching GRIA3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35049_g_at²^{, 3}	U95-A	1	1.00	1.00	0.96	0.76	U10301	1.00	1.00	1.00	1
90951_at²^{, 3}	U95-E	1	1.00	1.00	0.96	1.86	W22581	0.60	1.00	0.82	1
35048_at²^{, 3}	U95-A	1	1.00	1.00	0.93	1.04	U10301	1.00	1.00	1.00	1
42957_at²^{, 3}	U95-B	1	1.00	1.00	0.94	1.14	AI589333	0.60	1.00	0.82	1
208032_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000828	0.60	1.00	0.82	1
206730_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_007325	0.60	1.00	0.82	1
230144_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW294729	0.40	1.00	0.76	1
1569290_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208032_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206730_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
230144_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks GRIA3 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGGTATTGTA

SOURCE GeneReport for Unigene cluster: Hs.377070
Expression variation in blood from EXPOLDB for GRIA3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GRIA3 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GRIA3¹	--	glutamate receptor, ionotrophic, AMPA 3	94.67(n) 98.66(a)	492110 XM_859653.1 XP_864746.1
cow (Bos taurus)	GRIA3¹	--	glutamate receptor, ionotrophic, AMPA 3	94.89(n) 98.77(a)	534626 XM_614460.3 XP_614460.3
rat (Rattus norvegicus)	Gria3¹	--	glutamate receptor, ionotrophic, AMPA 3	94.59(n) 99.44(a)	29628 NM_032990.1 NP_116785.1
mouse (Mus musculus)	Gria3^{1, 5}	X (13.30 cM)⁵	glutamate receptor, ionotropic, AMPA3 (alpha 3)^{1, 5}	95.01(n)¹ 99.32(a)¹	53623¹ NM_016886.2¹ NP_058582.2¹ AB022342⁵ AB079072⁵ (see all 26)
chicken (Gallus gallus)	GRIA3¹	--	glutamate receptor, ionotrophic, AMPA 3	83.86(n) 94.82(a)	396138 NM_205215.1 NP_990546.1

About this table Species with no ortholog for GRIA3

ENSEMBL Gene Tree for GRIA3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for GRIA3 gene

GRIA2² GRIA4² GRIA1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1058 NCBI SNPs in GRIA3 are shown (see all 1058 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 404)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3761555^1,2	A,C,F,H	122144118(-)	`ATAGAA/GATCTT`	2	--	ng5¹		4		EU EA WA	416
	rs3761554^1,2	A,C,F,H	122144925(-)	`TGCTGA/GGCAGT`	2	--	ng5¹		4		EU EA WA	418
	rs35601010^1,2	C,F,H	122450532(+)	`GTATGT/CGAAAA`	2	--	ut3¹		4		EU EA WA	420
	rs5911540^1,2	A,C	122144782(+)	`ACCCCA/CAGACC`	2	--	ng5¹		0	--	--	--	--
	rs1052542^1,2	H	122427249(+)	`AAGGCC/ATCTTG`	2	I/L	mis¹ int¹ ese³		4		EU EA WA	406
--	rs1052540^1,2	H	122427238(+)	`ACTGAA/GTGAGC`	2	N/S	mis¹ int¹		4		EU EA WA	402
	rs1052538^1,2	H	122379008(+)	`CCATTC/AATGAG`	2	L/F	mis¹		4		EU EA WA	406
	rs502434^1,2	A,C,F,H,O	122364958(-)	`TACTCG/ATTCCA`	2	N/N	syn¹ ese³		11		MN EU EA WA NA	890
--	rs688688^1,2	A,C,F,H,O	122362658(-)	`ATCCCA/GTCTGG`	2	--	int¹		4		EU EA WA	416
	rs545958^1,2	A,C,F,H,O	122405251(-)	`AGGTAG/AGAGTG`	2	--	int¹		7		EU EA WA NA	531

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HapMap Linkage Disequilibrium images for GRIA3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 305915 disorders: 300699

UniProtKB/Swiss-Prot: GRIA3_HUMAN, P42263

Defects in GRIA3 are the cause of mental retardation X-linked type 94 (MRX94)

[MIM:300699]. Mental retardation is characterized by significantly sub-average general

intellectual functioning associated with impairments in adaptative behavior and manifested during

the developmental period. MRX94 patients have moderate mental retardation. Other variable features

are macrocephaly, seizures, myoclonic jerks, autistic behavior, asthenic body habitus, distal

muscle weakness and hyporeflexia

5 Novoseek disease relationships for GRIA3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rasmussen encephalitis	84.85	11	15249609 (3), 12761821 (2), 10441169 (1), 8559386 (1) (see all 5)
epilepsy	41.42	14	16278146 (2), 15249609 (2), 10441169 (1), 10441170 (1) (see all 6)
bipolar disorder	32.67	3	15264227 (1), 10644433 (1)
schizophrenia	18.41	1	11058479 (1)
neurodegeneration	9.89	3	8182436 (2)

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Human Gene Mutation Database: GRIA3
Human Genome Epidemiology Navigator: GRIA3 (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/100 PubMed articles for GRIA3 gene (see all 100 ):

Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq. (PubMed id 10602120)^{1, 3, 4} Amir R.... Zoghbi H.Y. (2000)
Characterization of the human glutamate receptor subunit 3 gene (GRIA3), a candidate for bipolar disorder and nonspecific X-linked mental retardation. (PubMed id 10644433)^{1, 2, 3} Gecz J....Mulley J.C. (1999)
Mutations in ionotropic AMPA receptor 3 alter channel properties and are associated with moderate cognitive impairment in humans. (PubMed id 17989220)^{3, 4} Wu Y.... Wang T. (2007)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{3, 4} Ross M.T.... Bentley D.R. (2005)
Human glutamate receptor hGluR3 flip and flop isoforms: cloning and sequencing of the cDNAs and primary structure of the proteins. (PubMed id 7918660)^{3, 4} Rampersad V.... Kamboj R.K. (1994)
Chromosomal localization of human glutamate receptor genes. (PubMed id 1319477)^{2, 3} McNamara J.O....Heinemann S.F. (1992)
TCR activation eliminates glutamate receptor GluR3 from the cell surface of normal human T cells, via an autocrine/paracrine granzyme B-mediated proteolytic cleavage. (PubMed id 17202328)^{1, 3} Ganor Y....Levite M. (2007)
Ca2+ permeability of KA-AMPA--gated glutamate receptor channels depends on subunit composition. (PubMed id 1709304)^{1, 3} Hollmann M....Heinemann S. (1991)
Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)³ Need A.C....Goldstein D.B. (2009)
Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients. (PubMed id 19295509)³ Perlis R.H....McMahon F.J. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2892	HGNC: 4573	AceView: GRIA3	Ensembl:ENSG00000125675	euGenes: HUgn2892
ECgene: GRIA3	H-InvDB: GRIA3

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for GRIA3
(Available from WIS Yeda, Salk, Tufts)

About This Section

Licensable Technologies for GRIA3 gene:

Weizmann Institute:

"Anti-glutamate Receptor GluR3B for Diagnosis, Research and Drug Discovery in Epilepsy"

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for GRIA3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GRIA3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GRIA3		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GRIA3		Small molecules for GRIA3
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GRIA3)
	Antibodies (GRIA3)
	Chimera RNAi (GRIA3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for GRIA3 (GluR3)

	Recombinant Proteins (Ionotropic glutamate receptor 2 + 3, Glutamate receptor 3)
	Antibodies (Ionotropic glutamate receptor 2 + 3, Glutamate receptor 3)

Search OriGene for GRIA3

Tocris compounds for GRIA3

	Drugs for GRIA3
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GRIA3

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
GRIA3 Gene at Home site.
Version 2.41.1
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GRIA3 Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for GRIA3

Summaries
for GRIA3

Genomic Location
for GRIA3

Proteins
for GRIA3

Protein Domains/
Families
for GRIA3

Gene Function
for GRIA3

Pathways & Interactions
for GRIA3

Drugs & Compounds
for GRIA3

Transcripts
for GRIA3

Expression
for GRIA3

Orthologs
for GRIA3

Paralogs
for GRIA3

SNPs/Variants
for GRIA3

Disorders & Mutations
for GRIA3

Medical News
for GRIA3

Publications
for GRIA3

Search for GRIA3

Genome Databases showing GRIA3

Other Databases showing GRIA3

Specialized Databases showing GRIA3

Licensable Technologies
for GRIA3

Services
for GRIA3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GRIA3 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor GRIA3

Summariesfor GRIA3

Genomic Locationfor GRIA3

Proteinsfor GRIA3

Protein Domains/Familiesfor GRIA3

Gene Functionfor GRIA3

Pathways & Interactionsfor GRIA3

Drugs & Compoundsfor GRIA3

Transcriptsfor GRIA3

Expression for GRIA3

Orthologsfor GRIA3

Paralogsfor GRIA3

SNPs/Variantsfor GRIA3

Disorders & Mutationsfor GRIA3

Medical Newsfor GRIA3

Publicationsfor GRIA3

Search for GRIA3

Genome Databases showing GRIA3

Other Databases showing GRIA3

Specialized Databases showing GRIA3

Licensable Technologiesfor GRIA3

Servicesfor GRIA3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GRIA3

Summaries
for GRIA3

Genomic Location
for GRIA3

Proteins
for GRIA3

Protein Domains/
Families
for GRIA3

Gene Function
for GRIA3

Pathways & Interactions
for GRIA3

Drugs & Compounds
for GRIA3

Transcripts
for GRIA3

Expression
for GRIA3

Orthologs
for GRIA3

Paralogs
for GRIA3

SNPs/Variants
for GRIA3

Disorders & Mutations
for GRIA3

Medical News
for GRIA3

Publications
for GRIA3

Licensable Technologies
for GRIA3

Services
for GRIA3