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GRIA3 Gene

protein-coding   GIFtS: 72
GCID: GC0XP122318

Glutamate Receptor, Ionotropic, AMPA 3

(Previous names: glutamate receptor, ionotrophic, AMPA 3)
(Previous symbol: GLUR3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutamate Receptor, Ionotropic, AMPA 31 2     dJ1171F9.12
GLUR31 2 3 5     gluR-32
Glutamate Receptor, Ionotrophic, AMPA 31 2     Glutamate Receptor 32
GLURC2 3     Glutamate Receptor C2
GluA32 3     Glutamate Receptor Subunit 32
AMPA-Selective Glutamate Receptor 32 3     GluR-33
MRX942 5     GluR-C3
GLUR-C2     GluR-K33
GLUR-K32     Glutamate Receptor Ionotropic, AMPA 33

External Ids:    HGNC: 45731   Entrez Gene: 28922   Ensembl: ENSG000001256757   OMIM: 3059155   UniProtKB: P422633   

Export aliases for GRIA3 gene to outside databases

Previous GC identifers: GC0XP117035 GC0XP119211 GC0XP120270 GC0XP121015 GC0XP122044 GC0XP122145 GC0XP111704


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GRIA3 Gene:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are
activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes
composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate
receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene
belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate
receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in
different isoforms, which may vary in their signal transduction properties. (provided by RefSeq, Jul 2008)

GeneCards Summary for GRIA3 Gene:
GRIA3 (glutamate receptor, ionotropic, AMPA 3) is a protein-coding gene. Diseases associated with GRIA3 include rasmussen encephalitis, and x-linked intellectual disability due to gria3 anomalies. GO annotations related to this gene include extracellular-glutamate-gated ion channel activity and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity. An important paralog of this gene is GRIK5.

UniProtKB/Swiss-Prot: GRIA3_HUMAN, P42263
Function: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and
plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter
at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a
conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an
electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized
by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is
characterized by a delayed accumulation of current flux upon continued application of glutamate

summary for GRIA3 Gene:
AMPA receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and
kainate receptors. AMPA receptors mediate fast excitatory synaptic transmission in the CNS and play a key
role in hippocampal synaptic long-term potentiation (LTP) and depression (LTD). AMPA receptors consist of
GluR1-4 subunits which assemble as homomers or heteromers to form functional AMPA receptors. The subunit
composition determines the physiological properties of AMPA receptors: those containing the GluR2 subunit
show low permeability to Ca2+ whereas those lacking this subunit show high Ca2+ permeability.

Gene Wiki entry for GRIA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011786.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the GRIA3 gene promoter:
         Spz1   p53   CUTL1   Nkx2-5   GATA-1   C/EBPalpha   FOXL1   MZF-1   Hlf   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRIA3 promoter sequence
   Search Chromatin IP Primers for GRIA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRIA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq25   Ensembl cytogenetic band:  Xq25   HGNC cytogenetic band: Xq25

GRIA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRIA3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP122318:  view genomic region     (about GC identifiers)

Start:
122,318,006 bp from pter      End:
122,624,766 bp from pter
Size:
306,761 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GRIA3_HUMAN, P42263 (See protein sequence)
Recommended Name: Glutamate receptor 3 precursor  
Size: 894 amino acids; 101157 Da
Subunit: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by
the dimerization of dimers. Interacts with PRKCABP, GRIP1 and GRIP2 (By similarity). Found in a complex with
GRIA1, GRIA2, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5 (By
similarity)
Miscellaneous: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to
their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate
Caution: It is uncertain whether Met-1 or Met-7 is the initiator
Secondary accessions: D3DTF1 Q4VXD5 Q4VXD6 Q9HDA0 Q9HDA1 Q9HDA2 Q9P0H1
Alternative splicing: 2 isoforms:  P42263-1   P42263-2   

Explore the universe of human proteins at neXtProt for GRIA3: NX_P42263

Explore proteomics data for GRIA3 at MOPED

Post-translational modifications: 

  • Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-621 palmitoylation leads to Golgi retention and
    decreased cell surface expression. In contrast, Cys-847 palmitoylation does not affect cell surface expression
    but regulates stimulation-dependent endocytosis (By similarity)1
  • Glycosylation2 at Asn63, Asn266, Asn380, Asn415, Asn422
  • Modification sites at PhosphoSitePlus

  • See GRIA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000819.3  NP_001243672.1  NP_015564.4  

    ENSEMBL proteins: 
     ENSP00000360313   ENSP00000360311   ENSP00000360297   ENSP00000360302   ENSP00000264357  
     ENSP00000446146   ENSP00000446440  
    Reactome Protein details: P42263

    GRIA3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GRI: Ligand-gated ion channels / Glutamate receptors, ionotropic
    GR: Glutamate receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GluA3
    Ionotropic glutamate receptors

    5 InterPro protein domains:
     IPR028082 Peripla_BP_I
     IPR019594 Glu_rcpt_Glu/Gly-bd
     IPR001320 Iontro_glu_rcpt
     IPR001828 ANF_lig-bd_rcpt
     IPR001508 NMDA_rcpt

    Graphical View of Domain Structure for InterPro Entry P42263

    ProtoNet protein and cluster: P42263

    3 Blocks protein domains:
    IPB001320 Ionotropic glutamate receptor
    IPB001508 NMDA receptor signature
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GRIA3_HUMAN, P42263
    Domain: The M4 transmembrane segment mediates tetramerization and is required for cell surface expression (By
    similarity)
    Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA3 subfamily


    GRIA3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRIA3_HUMAN, P42263
    Function: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and
    plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter
    at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a
    conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an
    electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized
    by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is
    characterized by a delayed accumulation of current flux upon continued application of glutamate

         Genatlas biochemistry entry for GRIA3:
    glutamate receptor,subunit 3,ionotropic,AMPA (amino-3-hydroxy 5 methyl-isoxazole-propionic) class,with flip and
    flop isoforms,mediating the fast component of excitatory post synaptic currents in the central nervous
    system,interacting with and signaling through the protein-kinase LYN

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004970ionotropic glutamate receptor activity ----
    GO:0004971alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity IDA--
    GO:0005215transporter activity ----
    GO:0005234extracellular-glutamate-gated ion channel activity IBA--
    GO:0005515protein binding ----
         
    GRIA3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GRIA3:
     Increased S DNA content 

         7 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Gria3):
     behavior/neurological  growth/size/body  integument  mortality/aging  nervous system 
     no phenotypic analysis  reproductive system 

    GRIA3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GRIA3: Gria3tm2Rlh Gria3tm1Zpj Gria3tm1Ksak Gria3tm1Rlh Gria3tm1.1Rsp

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRIA3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRIA3
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    hsa-miR-4328 hsa-miR-128 hsa-miR-25 hsa-let-7a-2* hsa-miR-488 hsa-miR-759 hsa-miR-124 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidGRIA3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIA3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GRIA3_HUMAN, P42263: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell
    membrane; Multi-pass membrane protein. Note=Interaction with CNIH2 and CNIH3 promotes cell surface expression (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton1
    cytosol1
    extracellular1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0030054cell junction IEA--
    GO:0030425dendrite IBA--

    GRIA3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GRIA3 About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1Trafficking of AMPA receptors
    Trafficking of AMPA receptors1.00
    Trafficking of GluR2-containing AMPA receptors0.00
    Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity1.00
    Activation of AMPA receptors0.00
    2Circadian entrainment
    Retrograde endocannabinoid signaling0.51
    Glutamatergic synapse0.39
    Circadian entrainment0.40
    Dopaminergic synapse0.37
    3Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    4Post NMDA receptor activation events
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.90
    Unblocking of NMDA receptor, glutamate binding and activation0.00
    5CREB Pathway
    CREB Pathway0.68
    Intracellular Calcium Signaling0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GRIA3
        Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Pathogenesis of ALS
    CREB Pathway
    Intracellular Calcium Signaling
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    1 Cell Signaling Technology (CST) Pathway for GRIA3
        Neuroscience

    1 GeneGo (Thomson Reuters) Pathway for GRIA3
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    2 BioSystems Pathways for GRIA3
        Hypothetical Network for Drug Addiction
    BDNF signaling pathway


    4 Reactome Pathways for GRIA3
        Unblocking of NMDA receptor, glutamate binding and activation
    Trafficking of AMPA receptors
    Trafficking of GluR2-containing AMPA receptors
    Activation of AMPA receptors


    Selected Kegg Pathways  (Kegg details for GRIA3) (see all 9):
        Neuroactive ligand-receptor interaction
    Circadian entrainment
    Retrograde endocannabinoid signaling
    Glutamatergic synapse
    Dopaminergic synapse


    GRIA3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRIA3: 
              Parkinson's Disease in human mouse rat
              Neurotransmitter Receptors in human mouse rat
              GABA & Glutamate in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GRIA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GRIA3 (P422633 ENSP000003603024) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRIA2P422623, ENSP000002644264I2D: score=4 STRING: ENSP00000264426
    SDCBPO005603, ENSP000002601304I2D: score=4 STRING: ENSP00000260130
    NSFP464593, ENSP000003812934I2D: score=2 STRING: ENSP00000381293
    SQSTM1Q135013, ENSP000003744554I2D: score=2 STRING: ENSP00000374455
    PPM1GO153553, ENSP000002647144I2D: score=1 STRING: ENSP00000264714
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS1709304
    GO:0007215glutamate receptor signaling pathway TAS1709304
    GO:0007268synaptic transmission TAS--
    GO:0034220ion transmembrane transport IBA--
    GO:0035235ionotropic glutamate receptor signaling pathway IDA--

    GRIA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for GRIA3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CNQX disodium saltPotent AMPA/kainate antagonist. More water soluble form of CNQX (Cat. No. 0190)[115066-14-3]
    Naspm trihydrochlorideCa2+-permeable AMPA receptor antagonist[122306-11-0]
    NBQXPotent AMPA antagonist. More selective than CNQX (Cat. No. 0190)[118876-58-7]
    DNQX disodium saltSelective non-NMDA antagonist. Water-soluble salt of DNQX (Cat. No. 0189)[2379-57-9]
    NBQX disodium saltPotent AMPA antagonist. More water soluble form of NBQX (Cat. No. 0373)[118876-58-7]

    3 DrugBank Compounds for GRIA3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--7679210 17139284 17016423
    Aniracetam-- 72432-10-1target--10592235
    Lithium-- 7439-93-2targetpotentiator10626836

    Selected IUPHAR Ligands for GRIA3 (GluA3) (see all 21)    About this table
    LigandTypeActionAffinityPubmed IDs
    S18986
    Allosteric regulatorPositive--
    LY392098
    Allosteric regulatorPositive--
    CX546
    Allosteric regulatorPositive--
    CX516
    Allosteric regulatorPositive--
    argiotoxin
    Channel blockerNone--
    joro toxin
    Channel blockerNone--
    piracetam
    Allosteric regulatorPositive--
    [3H]CNQX
    NoneNone--
    ATPO
    AntagonistAntagonist--
    GYKI53655
    AntagonistAntagonist--

    9 Novoseek inferred chemical compound relationships for GRIA3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid 81.1 7 10101246 (1), 17202328 (1), 17256974 (1), 12761821 (1) (see all 6)
    glutamate 77.3 60 16278146 (2), 17202328 (2), 15249609 (2), 1372254 (1) (see all 38)
    kainate 76.9 19 8133291 (2), 1709304 (2), 9729352 (2), 9525931 (1) (see all 11)
    nmda 62.1 7 7682696 (1), 8873866 (1), 1709304 (1), 9729352 (1) (see all 6)
    calcium 25.8 10 9106453 (3), 1372254 (2), 16344514 (1), 1709304 (1) (see all 6)
    pentobarbital 23.8 1 8088363 (1)
    gaba 21.3 2 10602120 (1)
    magnesium 0 1 9106453 (1)
    zinc 0 11 8015375 (6), 9106453 (3)

    3 PharmGKB related drug/compound annotations for GRIA3 gene    About this table
    Drug/compound PharmGKB Annotation
    Selective serotonin reuptake inhibitorsCA  
    antidepressantsCA  
    venlafaxineCA  



    GRIA3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GRIA3 gene (4 alternative transcripts): 
    NM_000828.4  NM_001256743.1  NM_007325.4  NM_181894.1  

    Unigene Cluster for GRIA3:

    Glutamate receptor, ionotropic, AMPA 3
    Hs.377070  [show with all ESTs]
    Unigene Representative Sequence: NM_000828
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371266 ENST00000371264(uc010nqs.2) ENST00000371251 ENST00000371256
    ENST00000479118 ENST00000477389 ENST00000460123 ENST00000264357(uc004etq.4 uc004etr.4 uc004ets.4)
    ENST00000542149 ENST00000541091(uc011muf.1)

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    OriGene ORF clones in mouse, rat for GRIA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GRIA3 (NM_007325)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRIA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRIA3
    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat GRIA3

    Additional mRNA sequence: 

    AK297136.1 BC032004.1 BC117464.1 U10301.1 U10302.1 

    11 DOTS entries:

    DT.456066  DT.442710  DT.65288259  DT.121322982  DT.75138177  DT.121322946  DT.121322980  DT.121322984 
    DT.65288776  DT.97804511  DT.91744130 

    Selected AceView cDNA sequences (see all 86):

    BX119058 NM_007325 AV708569 AW207024 AI160594 AI680688 BE503011 BQ416790 
    BE220304 BM683403 AW166130 BX109400 BE220607 Z40626 NM_000828 AW166119 
    BF110551 AI358903 U10301 BX954052 AI379066 BM727286 Z44847 BG680842 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for GRIA3    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                          -           -     -                 -                                                                 -                     
    SP2:                          -           -     -                 -                                                                       -               
    SP3:                          -                                                                                                                           
    SP4:                                      -     -                                                                                                         
    SP5:                          -           -     -                                                                                                         


    ECgene alternative splicing isoforms for GRIA3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GRIA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTATTGTA
    GRIA3 Expression
    About this image


    GRIA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Visceral White Adipose
             HyStem+BMP4-induced 7SMOO32 cells
     
     Bone (Muscoskeletal System)
             Zeugopod Epiphyseal End
     
     Eye (Sensory Organs)
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Testis (Reproductive System)
             Testicular Interstitial Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
    GRIA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GRIA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.377070
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRIA3: 
              Parkinson's Disease in human mouse rat
              Neurotransmitter Receptors in human mouse rat
              GABA & Glutamate in human mouse rat
              Synaptic Plasticity in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GRIA3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gria31 , 5 glutamate receptor, ionotropic, AMPA3 (alpha 3)1, 5 95.08(n)1
    99.55(a)1
      X (23.19 cM)5
    536231  NM_001281929.11  NP_001268858.11 
     414008545 
    chicken
    (Gallus gallus)
    Aves GRIA31 glutamate receptor, ionotropic, AMPA 3 83.93(n)
    95.05(a)
      396138  NM_205215.2  NP_990546.2 
    lizard
    (Anolis carolinensis)
    Reptilia GRIA36
    glutamate receptor, ionotropic, AMPA 3
    92(a)
    1 ↔ 1
    GL343522.1(373590-498925)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gria31 glutamate receptor, ionotropic, AMPA 3 80.98(n)
    91.66(a)
      100127683  NM_001113023.1  NP_001106494.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gria32 glutamate receptor, ionotrophic, AMPA 3 80.3(n)   368416  AF525746.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Glu-RI3
    Glu-RIB1

    alpha-amino-3-hydroxy-5-methyl-4-isoxazole
    more3
    Glutamate receptor IB1
    42(a)
    (best of 6)3
    53.46(n)1
    50.25(a)1
      65C13
    444841  NM_001274693.11  NP_001261622.11 
    worm
    (Caenorhabditis elegans)
    Secernentea glr-11 , 3 Expression: neurons, RMD neurons, SMD
    neurons, more3
    glr-11
    48(a)
    (best of 2)3
    50.13(n)1
    43.38(a)1
      III(8655978-8660337)3
    1762041  NM_066486.61  NP_498887.21 


    ENSEMBL Gene Tree for GRIA3 (if available)
    TreeFam Gene Tree for GRIA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GRIA3 gene
    GRIK52  GRIK12  GRIA22  GRIA42  GRIK22  GRID12  GRIA12  GRIK42  
    GRIK32  GRID22  
    10 SIMAP similar genes for GRIA3 using alignment to 7 protein entries:     GRIA3_HUMAN (see all proteins):
    GRIA2    GRIA4    GRIA1    GRIK2    GRIK1    GRIK3
    GRIK4    GRIK5    GRID1    GRID2

    GRIA3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GRIA3 (see all 3862)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0434854
    Mental retardation, X-linked 94 (MRX94)4--see VAR_0434852 R S mis40--------
    VAR_0434844
    Mental retardation, X-linked 94 (MRX94)4--see VAR_0434842 R Q mis40--------
    VAR_0434874
    Mental retardation, X-linked 94 (MRX94)4--see VAR_0434872 G R mis40--------
    VAR_0434864
    Mental retardation, X-linked 94 (MRX94)4--see VAR_0434862 M T mis40--------
    rs1901367991,2
    --122269799(+) TTACTC/TAATTT 3 -- us2k10--------
    rs1826737921,2
    --122269881(+) CAAAGC/TTGTTC 3 -- us2k10--------
    rs1858475241,2
    --122269959(+) CATGTC/TCCCGA 3 -- us2k10--------
    rs1906002971,2
    --122270037(+) CTAATA/GCTTCT 3 -- us2k10--------
    rs736368471,2
    C,F--122270095(+) TCCTGC/TCCATG 3 -- us2k12Minor allele frequency- T:0.25WA 4
    rs37615551,2
    C,F,A,H--122270126(-) ATAGAG/AATCTT 3 -- us2k117Minor allele frequency- A:0.47NS EA NA WA CSA 1981

    HapMap Linkage Disequilibrium report for GRIA3 (122318006 - 122568006 bp, first 250kb of GRIA3)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for GRIA3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662475CNV Deletion23128226
    esv2740445CNV Deletion23290073
    nsv508797CNV Insertion20534489
    nsv7067CNV Insertion18451855
    esv22122CNV Loss19812545
    nsv512696CNV Loss21212237
    nsv511653CNV Loss21212237

    Human Gene Mutation Database (HGMD): GRIA3
    Locus Specific Mutation Databases (LSDB): GRIA3

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GRIA3
    DNA2.0 Custom Variant and Variant Library Synthesis for GRIA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 305915   
    OMIM disorders: 300699  
    UniProtKB/Swiss-Prot: GRIA3_HUMAN, P42263
  • Mental retardation, X-linked 94 (MRX94) [MIM:300699]: A disorder characterized by significantly below
    average general intellectual functioning associated with impairments in adaptive behavior and manifested during
    the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental
    retardation, while syndromic mental retardation presents with associated physical, neurological and/or
    psychiatric manifestations. MRX94 patients have moderate mental retardation. Other variable features are
    macrocephaly, seizures, myoclonic jerks, autistic behavior, asthenic body habitus, distal muscle weakness and
    hyporeflexia. Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for GRIA3 (see all 36):    
    About MalaCards
    rasmussen encephalitis    x-linked intellectual disability due to gria3 anomalies    autosomal dominant nonsyndromic deafness    sneddon syndrome
    canavan disease    auditory neuropathy    nonsyndromic deafness    drug addiction
    nicotine addiction    alcohol abuse    status epilepticus    encephalitis
    rett syndrome    antiphospholipid syndrome    mental retardation, x-linked    leukodystrophy
    bipolar disorder    temporal lobe epilepsy    mood disorder    migraine


    GRIA3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for GRIA3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rasmussen encephalitis 85.8 12 15249609 (3), 12761821 (2), 10441169 (1), 19810914 (1) (see all 6)
    epilepsy 42.7 16 16278146 (2), 15249609 (2), 10441169 (1), 19810914 (1) (see all 7)
    bipolar disorder 30.6 3 15264227 (1), 10644433 (1)
    schizophrenia 16.6 1 11058479 (1)
    neurodegeneration 7.47 3 8182436 (2)

    Genetic Association Database (GAD): GRIA3
    Human Genome Epidemiology (HuGE) Navigator: GRIA3 (10 documents)

    Export disorders for GRIA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GRIA3 gene, integrated from 10 sources (see all 132):
    (articles sorted by number of sources associating them with GRIA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human glutamate receptor subunit 3 gene (GRIA3), a candidate for bipolar disorder and nonspecific X-linked mental retardation. (PubMed id 10644433)1, 2, 3, 9 Gecz J.... Mulley J.C. (Genomics 1999)
    2. Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq. (PubMed id 10602120)1, 2, 9 Amir R.... Zoghbi H.Y. (Am. J. Med. Genet. 2000)
    3. A population-based association study of candidate genes for depression and sleep disturbance. (PubMed id 19548263)1, 4 Utge S....Paunio T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    4. Common variants in the regulative regions of GRIA1 and GRIA3 receptor genes are associated with migraine susceptibility. (PubMed id 20579352)1, 4 Formicola D....Esposito T. (BMC Med. Genet. 2010)
    5. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    6. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    7. Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients. (PubMed id 19295509)1, 4 Perlis R.H....McMahon F.J. (Neuropsychopharmacology 2009)
    8. Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation. (PubMed id 19736351)1, 4 Guilmatre A....Campion D. (Arch. Gen. Psychiatry 2009)
    9. Study on GRIA2, GRIA3 and GRIA4 genes highlights a positive association between schizophrenia and GRIA3 in female patients. (PubMed id 18163426)1, 4 Magri C....Barlati S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    10. Mutations in ionotropic AMPA receptor 3 alter channel properties and are associated with moderate cognitive impairment in humans. (PubMed id 17989220)1, 2 Wu Y.... Wang T. (Proc. Natl. Acad. Sci. U.S.A. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2892 HGNC: 4573 AceView: GRIA3 Ensembl:ENSG00000125675 euGenes: HUgn2892
    ECgene: GRIA3 Kegg: 2892 H-InvDB: GRIA3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GRIA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for GRIA3 gene:
    Search GeneIP for patents involving GRIA3

    Licensable Technologies for GRIA3 gene:
    Weizmann Institute:"Anti-glutamate Receptor GluR3B for Diagnosis, Research and Drug Discovery in Epilepsy"
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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