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Aliases for GRIA2 Gene

Aliases for GRIA2 Gene

  • Glutamate Ionotropic Receptor AMPA Type Subunit 2 2 3 5
  • Glutamate Receptor, Ionotropic, AMPA 2 2 3
  • AMPA-Selective Glutamate Receptor 2 3 4
  • GluR-K2 3 4
  • GluR-2 3 4
  • GluR-B 3 4
  • GLUR2 3 4
  • GluA2 3 4
  • Glutamate Receptor Ionotropic, AMPA 2 4
  • Glutamate Receptor B Flip Isoform 3
  • Glutamate Receptor 2 3
  • GLURB 3
  • HBGR2 3

External Ids for GRIA2 Gene

Previous HGNC Symbols for GRIA2 Gene

  • GLUR2

Previous GeneCards Identifiers for GRIA2 Gene

  • GC04P159021
  • GC04P158572
  • GC04P158719
  • GC04P158499
  • GC04P158361
  • GC04P158141
  • GC04P153892

Summaries for GRIA2 Gene

Entrez Gene Summary for GRIA2 Gene

  • Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRIA2 Gene

GRIA2 (Glutamate Ionotropic Receptor AMPA Type Subunit 2) is a Protein Coding gene. Diseases associated with GRIA2 include Status Epilepticus and Lateral Sclerosis. Among its related pathways are CREB Pathway and Neuroscience. GO annotations related to this gene include ionotropic glutamate receptor activity and AMPA glutamate receptor activity. An important paralog of this gene is GRIA4.

UniProtKB/Swiss-Prot for GRIA2 Gene

  • Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Tocris Summary for GRIA2 Gene

  • AMPA receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and kainate receptors. AMPA receptors mediate fast excitatory synaptic transmission and play a role in hippocampal synaptic long-term potentiation and depression.

Gene Wiki entry for GRIA2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIA2 Gene

Genomics for GRIA2 Gene

Regulatory Elements for GRIA2 Gene

Enhancers for GRIA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G157244 0.4 FANTOM5 13.8 +40.5 40499 0.2 RBFOX2 GRIA2 LOC391707 RNU6-582P LINC02433
GH04G157265 0.4 FANTOM5 10.5 +61.5 61459 0.3 USF2 GRIA2 LOC391707 RNU6-582P GLRB PDGFC LINC02433
GH04G156992 0.4 dbSUPER 9.3 -211.1 -211079 1.3 MNT ENSG00000250622 PDGFC RNU6-582P GRIA2 LOC391707 RPPH1-3P GC04P157065
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GRIA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GRIA2 Gene

Chromosome:
4
Start:
157,204,182 bp from pter
End:
157,366,075 bp from pter
Size:
161,894 bases
Orientation:
Plus strand

Genomic View for GRIA2 Gene

Genes around GRIA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIA2 Gene

Proteins for GRIA2 Gene

  • Protein details for GRIA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42262-GRIA2_HUMAN
    Recommended name:
    Glutamate receptor 2
    Protein Accession:
    P42262
    Secondary Accessions:
    • A8MT92
    • I6L997
    • Q96FP6

    Protein attributes for GRIA2 Gene

    Size:
    883 amino acids
    Molecular mass:
    98821 Da
    Quaternary structure:
    • Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4. Interacts with ATAD1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts binding to ATAD1 and to GRIP1 and leads to AMPAR complex disassembly (By similarity). Interacts with PICK1 (via PDZ domain). Interacts with PRKCABP and GRIP2 (By similarity). Interacts with GRIA1 and SYNDIG1 (By similarity). Interacts with LRFN1. Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes (By similarity). Found in a complex with GRIA1, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5 (By similarity). Interacts with OLFM2 (By similarity).
    Miscellaneous:
    • The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.

    Three dimensional structures from OCA and Proteopedia for GRIA2 Gene

    Alternative splice isoforms for GRIA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRIA2 Gene

Post-translational modifications for GRIA2 Gene

  • Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
  • Glycosylation at posLast=256256, posLast=370370, posLast=406406, and posLast=413413
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GRIA2 (GluR2)
  • Santa Cruz Biotechnology (SCBT) Antibodies for GRIA2

No data available for DME Specific Peptides for GRIA2 Gene

Domains & Families for GRIA2 Gene

Gene Families for GRIA2 Gene

Suggested Antigen Peptide Sequences for GRIA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P42262

UniProtKB/Swiss-Prot:

GRIA2_HUMAN :
  • The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily.
Domain:
  • The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily.
genes like me logo Genes that share domains with GRIA2: view

Function for GRIA2 Gene

Molecular function for GRIA2 Gene

GENATLAS Biochemistry:
glutamate receptor,subunit 2,ionotropic,AMPA (amino-3-hydroxy 5 methyl-isoxazole-propionic) class,with flip and flop isoforms,mediating the fast component of excitatory post synaptic currents in the central nervous system,interacting with and signaling through the protein-kinase LYN
UniProtKB/Swiss-Prot Function:
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Gene Ontology (GO) - Molecular Function for GRIA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004970 ionotropic glutamate receptor activity IDA,IEA 20614889
GO:0004971 AMPA glutamate receptor activity TAS,ISS --
GO:0005216 ion channel activity IEA --
GO:0005231 excitatory extracellular ligand-gated ion channel activity TAS --
GO:0005234 extracellular-glutamate-gated ion channel activity IEA --
genes like me logo Genes that share ontologies with GRIA2: view
genes like me logo Genes that share phenotypes with GRIA2: view

Animal Models for GRIA2 Gene

MGI Knock Outs for GRIA2:

Animal Model Products

  • Taconic Biosciences Mouse Models for GRIA2

CRISPR Products

miRNA for GRIA2 Gene

miRTarBase miRNAs that target GRIA2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRIA2 Gene

Localization for GRIA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIA2 Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRIA2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 3
extracellular 1
cytoskeleton 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GRIA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane ISS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GRIA2: view

Pathways & Interactions for GRIA2 Gene

genes like me logo Genes that share pathways with GRIA2: view

Gene Ontology (GO) - Biological Process for GRIA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0007165 signal transduction TAS 8003671
GO:0007268 chemical synaptic transmission TAS 8003671
GO:0034220 ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with GRIA2: view

No data available for SIGNOR curated interactions for GRIA2 Gene

Drugs & Compounds for GRIA2 Gene

(132) Drugs for GRIA2 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclothiazide Approved Pharma Positive, Allosteric regulator, inhibitor 0
Butabarbital Approved, Illicit Pharma antagonist, Target 0
Butalbital Approved, Illicit Pharma antagonist, Target 0
Butethal Approved, Illicit Pharma antagonist, Target 0
Methylphenobarbital Approved Pharma antagonist, Target 0

(6) Additional Compounds for GRIA2 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
dnqx
2379-57-9
3'-Hydroxyhexobarbital
427-29-2

(5) Tocris Compounds for GRIA2 Gene

Compound Action Cas Number
CNQX disodium salt Potent AMPA/kainate antagonist. More water soluble form of CNQX (Cat. No. 0190) 479347-85-8
DNQX Selective non-NMDA antagonist 2379-57-9
DNQX disodium salt Selective non-NMDA antagonist. Water-soluble salt of DNQX (Cat. No. 0189) 1312992-24-7
NBQX Potent AMPA antagonist. More selective than CNQX (Cat. No. 0190) 118876-58-7
NBQX disodium salt Potent AMPA antagonist. More water soluble form of NBQX (Cat. No. 0373) 479347-86-9

(62) ApexBio Compounds for GRIA2 Gene

Compound Action Cas Number
(R)-AMPA 83654-13-1
(RS)-AMPA 74341-63-2
(RS)-AMPA hydrobromide 171259-81-7
(S)-(-)-5-Fluorowillardiine 140187-23-1
(S)-AMPA 83643-88-3
(S)-CPW 399 AMPA agonist,subtype-selective,weakly desensitizing 389888-02-2
1-BCP 34023-62-6
ADX-47273 851881-60-2
Ampalex Ampakine and nootropic 154235-83-3
Aniracetam Nootropic drug for senile dementia 72432-10-1
CFM-2 178616-26-7
Cl-HIBO 909400-43-7
CMPDA 380607-77-2
CNQX 115066-14-3
CNQX disodium salt 479347-85-8
CP 465022 hydrochloride AMPA receptor antagonist, non-competitive and selective 199655-36-2
CX 546 215923-54-9
Cyclothiazide 2259-96-3
Diazoxide 364-98-7
DNQX disodium salt 1312992-24-7
Evans Blue tetrasodium salt potent inhibitor of AMPA and kainate receptor-mediated currents (GluRl and GIuR6) 314-13-6
GYKI 47261 dihydrochloride AMPA receptor antagonist, non-competitive and selective 1217049-32-5
GYKI 52466 dihydrochloride 102771-26-6
GYKI 53655 hydrochloride 143692-48-2
IDRA 21 22503-72-6
IEM 1460 121034-89-7
IEM 1754 dihydrobroMide 162831-31-4
IEM 1925 dihydrobromide 258282-23-4
Ifenprodil Tartrate NMDA receptor antagonist 23210-58-4
Latrepirdine Brain cell death inhibitor 97657-92-6
L-Quisqualic acid 52809-07-1
LY450108 AMPA receptor potentiator 376594-67-1
LY451395 Allosteric modulator 375345-95-2
Naspm trihydrochloride 1049731-36-3
NBQX 118876-58-7
NBQX disodium salt 479347-86-9
NMDA (N-Methyl-D-aspartic acid) NMDA receptor agonist 6384-92-5
Noopept Nootropic and neuroprotective agent 157115-85-0
NPEC-caged-(S)-AMPA 1257323-84-4
Pep1-AGL
Pep1-TGL
pep2-AVKI 1315378-69-8
pep2-EVKI 1315378-67-6
pep2m 243843-42-7
Pep2m, myristoylated
pep2-SVKE 1315378-76-7
pep2-SVKI 328944-75-8
pep4c 243843-43-8
PEPA 141286-78-4
Perampanel AMPA-type glutamate receptor antagonist 380917-97-5
PF 4778574 1219633-99-4
Philanthotoxin 74 1227301-51-0
S 18986 175340-20-2
SYM 2206 173952-44-8
Talampanel(LY300164) AMPA-receptor antagonist 161832-65-1
Tezampanel AMPA and receptor antagonist 154652-83-2
UBP 282 544697-47-4
VU 0361737 MGlu4 receptor allosteric modulator 1161205-04-4
VU 0364439 Positive allosteric mGluR-4 modulator 1246086-78-1
VU 0364770 61350-00-3
YM 90K hydrochloride 154164-30-4
ZK 200775 161605-73-8
genes like me logo Genes that share compounds with GRIA2: view

Drug Products

Transcripts for GRIA2 Gene

Unigene Clusters for GRIA2 Gene

Glutamate receptor, ionotropic, AMPA 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIA2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20
SP1: - - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5:
SP6: -

Relevant External Links for GRIA2 Gene

GeneLoc Exon Structure for
GRIA2
ECgene alternative splicing isoforms for
GRIA2

Expression for GRIA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRIA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIA2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.5), Brain - Anterior cingulate cortex (BA24) (x6.0), Brain - Cortex (x4.8), and Brain - Nucleus accumbens (basal ganglia) (x4.6).

Protein differential expression in normal tissues from HIPED for GRIA2 Gene

This gene is overexpressed in Brain (22.1), Fetal Brain (17.3), and Frontal cortex (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRIA2 Gene



Protein tissue co-expression partners for GRIA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GRIA2 Gene:

GRIA2

SOURCE GeneReport for Unigene cluster for GRIA2 Gene:

Hs.32763

Evidence on tissue expression from TISSUES for GRIA2 Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with GRIA2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRIA2 Gene

Orthologs for GRIA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRIA2 34 35
  • 99.66 (n)
oppossum
(Monodelphis domestica)
Mammalia GRIA2 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRIA2 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GRIA2 34 35
  • 94.41 (n)
rat
(Rattus norvegicus)
Mammalia Gria2 34
  • 93.92 (n)
mouse
(Mus musculus)
Mammalia Gria2 34 16 35
  • 93.85 (n)
dog
(Canis familiaris)
Mammalia GRIA2 34 35
  • 93.8 (n)
chicken
(Gallus gallus)
Aves GRIA2 34 35
  • 88.41 (n)
lizard
(Anolis carolinensis)
Reptilia GRIA2 35
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gria2 34
  • 84.05 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8583 34
zebrafish
(Danio rerio)
Actinopterygii gria2a 35
  • 84 (a)
OneToMany
gria2b 35
  • 82 (a)
OneToMany
gria2.2 34
fruit fly
(Drosophila melanogaster)
Insecta CG11155 36
  • 51 (a)
Glu-RI 36
  • 41 (a)
CG9935 36
  • 39 (a)
Glu-RIB 36
  • 35 (a)
Kai-RIA 36
  • 35 (a)
CG15627 36
  • 33 (a)
Glu-RIIA 36
  • 30 (a)
CG4226 36
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea glr-1 36
  • 38 (a)
glr-4 36
  • 31 (a)
Species where no ortholog for GRIA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRIA2 Gene

ENSEMBL:
Gene Tree for GRIA2 (if available)
TreeFam:
Gene Tree for GRIA2 (if available)

Paralogs for GRIA2 Gene

Paralogs for GRIA2 Gene

genes like me logo Genes that share paralogs with GRIA2: view

Variants for GRIA2 Gene

Sequence variations from dbSNP and Humsavar for GRIA2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000055297 -- 157,339,399(+) TTCCT(G/T)CTCTG intron-variant
rs1000062138 -- 157,304,508(+) GGTGT(C/T)TTTAA intron-variant
rs1000073527 -- 157,325,931(+) TATAA(A/G)TAGAT intron-variant
rs1000090272 -- 157,349,941(+) GTTAG(A/G)TTACA intron-variant
rs1000090689 -- 157,259,735(+) ACAAA(C/G)TCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRIA2 Gene

Variant ID Type Subtype PubMed ID
dgv1038e214 CNV gain 21293372
esv1631445 CNV insertion 17803354
esv2759291 CNV gain 17122850
esv3602808 CNV loss 21293372
esv3602809 CNV gain 21293372
esv3602810 CNV gain 21293372
nsv1017691 CNV gain 25217958
nsv1018387 CNV gain 25217958
nsv1031579 CNV gain 25217958
nsv1073809 CNV deletion 25765185
nsv1116403 CNV insertion 24896259
nsv293530 CNV insertion 16902084
nsv830123 CNV gain 17160897

Variation tolerance for GRIA2 Gene

Residual Variation Intolerance Score: 10.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRIA2 Gene

Human Gene Mutation Database (HGMD)
GRIA2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRIA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIA2 Gene

Disorders for GRIA2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for GRIA2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
status epilepticus
  • gcse
lateral sclerosis
  • motor neuron disease
fraser syndrome
  • cryptophthalmos syndrome
motor neuron disease
  • motor neuron diseases
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search GRIA2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GRIA2

Genetic Association Database (GAD)
GRIA2
Human Genome Epidemiology (HuGE) Navigator
GRIA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRIA2
genes like me logo Genes that share disorders with GRIA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRIA2 Gene

Publications for GRIA2 Gene

  1. Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors. (PMID: 19651138) Clayton A. … Aricescu A.R. (J. Mol. Biol. 2009) 3 4 22 64
  2. Primary structure and functional expression of the AMPA/kainate receptor subunit 2 from human brain. (PMID: 8003671) Sun W. … Montal M. (NeuroReport 1994) 3 4 22 64
  3. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PMID: 20398908) Saus E. … Estivill X. (J Psychiatr Res 2010) 3 46 64
  4. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro A.P. … Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  5. Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2- yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator. (PMID: 20614889) Ward S.E. … Yusaf S.P. (J. Med. Chem. 2010) 3 4 64

Products for GRIA2 Gene

Sources for GRIA2 Gene

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