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GRIA2 Gene

protein-coding GIFtS: 69

GC04P158361

glutamate receptor, ionotropic, AMPA 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GLUR2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
GLUR2 ^², ³, ⁵
GLURB ^¹, ²
GluR-2 ^³
GluR-B ^³
GluR-K2 ^², ³
HBGR2 ^²
OTTHUMP00000165324 ^²
gluR-B ^²

Descriptions
AMPA-selective glutamate receptor 2 ^³
Glutamate receptor ionotropic, AMPA 2 ^³
glutamate receptor 2 ^²
glutamate receptor, ionotropic, AMPA 2 ^²

External Ids
HGNC: 4572¹
Entrez Gene: 2891²
UniProtKB: P42262³
Ensembl: ENSG00000120251⁷

Search outside databases for aliases for GRIA2 gene

Previous GC identifers: GC04P159021 GC04P158572 GC04P158719 GC04P158499

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GRIA2:

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian

brain and are activated in a variety of normal neurophysiologic processes. This gene product

belongs to a family of glutamate receptors that are sensitive to

alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated

cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit

encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second

transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and

animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2

RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology.

Alternative splicing, resulting in transcript variants encoding different isoforms, (including the

flip and flop isoforms that vary in their signal transduction properties), has been noted for this

gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: GRIA2_HUMAN, P42262

Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many

synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate

induces a conformation change, leading to the opening of the cation channel, and thereby converts

the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a

transient inactive state, characterized by the presence of bound agonist

Gene Wiki entry for GRIA2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GRIA2 gene

Entrez Gene cytogenetic band: 4q32-q33 Ensembl cytogenetic band: 4q32.1 HGNC cytogenetic band: 4q32-q33

GRIA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P158361: (about GC identifiers)

Start:	158,361,186 bp from pter
End:	158,506,677 bp from pter
Size:	145,492 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: GRIA2_HUMAN, P42262 (See protein sequence)

Recommended Name: Glutamate receptor 2 precursor

Size: 883 amino acids; 98821 Da

Subunit: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may

be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with

GRIP1 and CSPG4. Interacts with PRKCABP, GRIP1 and GRIP2 (By similarity)

Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse,

postsynaptic cell membrane; Multi-pass membrane protein

Rna editing: Modified_positions=607; Note=Partially edited. Fully edited in the brain.

Heteromerically expressed edited GLUR2 (R) receptor complexes are impermeable to calcium, whereas

the unedited (Q) forms are highly permeable to divalent ions

Miscellaneous: The postsynaptic actions of Glu are mediated by a variety of receptors that are

named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate >

kainate

Secondary accessions: Q96FP6

Alternative splicing: 3 isoforms: P42262-1 P42262-2 P42262-3

Post-translational modifications:

Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi

retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not

affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_000817.2 NP_001077088.1 NP_001077089.1

ENSEMBL proteins:

ENSP00000318144 ENSP00000377403 ENSP00000296526 ENSP00000264426

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant GRIA2 Protein
	Sigma-Aldrich AQUA Peptides for GRIA2
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Ionotropic Glutamate receptor 2, Ionotropic glutamate receptor 2 + 3)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/15 Gene Ontology (GO) cellular component terms (links to tree view) (see all 15 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	IEA	--
GO:0005886	plasma membrane	TAS	8003671
GO:0014069	postsynaptic density	IEA	--
GO:0016021	integral to membrane	IEA	--
GO:0030054	cell junction	IEA	--

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Antibodies for GRIA2:

	Invitrogen Antibodies for GRIA2
	Millipore Mono- and Polyclonal Antibodies for the study of GRIA2
	Sigma-Aldrich Antibodies for GRIA2
	R&D Systems Antibodies for GRIA2 (GluR2)
	Cell Signaling Technology (CST) Antibodies for GRIA2 (GluR2, AMPA Receptor)
	Antibodies from Abcam (Ionotropic Glutamate receptor 2, Ionotropic glutamate receptor 2 + 3), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibody for GRIA2

Assays for GRIA2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P42262

ProtoNet protein and cluster: P42262

3 Blocks protein families:

IPB001320 Ionotropic glutamate receptor

IPB001508 NMDA receptor signature

IPB001828 Extracellular ligand-binding receptor

UniProtKB/Swiss-Prot: GRIA2_HUMAN, P42262

Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GRIA2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GRIA2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001083619

Applied Biosystems Silencer® siRNAs for GRIA2

Sigma-Aldrich siRNA and siRNA Panels for GRIA2

Sigma-Aldrich shRNA for GRIA2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000826
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000826
untagged cDNA clones in CMV expression vector (see all 3): NM_000826

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001083619

UniProtKB/Swiss-Prot: GRIA2_HUMAN, P42262

Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many

synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate

induces a conformation change, leading to the opening of the cation channel, and thereby converts

the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a

transient inactive state, characterized by the presence of bound agonist

Genatlas biochemistry entry for GRIA2:

glutamate receptor,subunit 2,ionotropic,AMPA (amino-3-hydroxy 5 methyl-isoxazole-propionic)

class,with flip and flop isoforms,mediating the fast component of excitatory post synaptic

currents in the central nervous system,interacting with and signaling through the protein-kinase

LYN

11 MGI mutant phenotypes (inferred from 12 alleles) (MGI details for Gria2):

behavior/neurological	cellular	growth/size	hearing/vestibular/ear	lethality-postnatal
life span-post-weaning/aging	nervous system	no phenotypic analysis	normal	reproductive system
touch/vibrissae

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004971	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	TAS	8003671
GO:0005216	ion channel activity	IEA	--
GO:0005234	extracellular-glutamate-gated ion channel activity	IEA	--
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for GRIA2 (Your Favorite Gene powered by Ingenuity) (see all 7 )

Synaptic Long Term Potentiation
Glutamate Receptor Signaling
Synaptic Long Term Depression
Amyotrophic Lateral Sclerosis Signaling
Calcium Signaling

GeneDecks GRIA2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for GRIA2

5/33 Interacting proteins for GRIA2 (ENSP00000264426³ P42262²) via UniProtKB, MINT, and/or STRING (see all 33 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NSF	P46459²	STRING (score=.915) MINT-2791974 MINT-2791723
PICK1	ENSP00000349465³	STRING (score=.995)
GRIA3	ENSP00000360302³	STRING (score=.973)
GRIP1	ENSP00000352780³	STRING (score=.965)
CAMK2G	ENSP00000319060³	STRING (score=.944)

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5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001919	regulation of receptor recycling	IEA	--
GO:0006811	ion transport	IEA	--
GO:0007165	signal transduction	TAS	8003671
GO:0010226	response to lithium ion	IEA	--
GO:0031623	receptor internalization	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for GRIA2

Sigma-Aldrich Small Molecules for GRIA2:

Mixed Agonist/Antagonist Antagonist Blocker Allosteric Modulator Agonist

Compounds for GRIA2 available from Tocris Bioscience

Compound	Action	CAS number
(S)-AMPA	Selective AMPA agonist. Active isomer of (RS)-AMPA (Cat. No. 0169)	[83643-88-3]
CP 465022 hydrochloride	Selective, non-competitive AMPA antagonist	[199655-36-2]
A 769662	Potent AMPK activator	[844499-71-4]
GYKI 52466 hydrochloride	Selective non-competitive AMPA antagonist	[102771-26-6]
NBQX disodium salt	More water soluble form of NBQX (Cat. No. 0373)	[118876-58-7]

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7 Novoseek chemical compound relationships for GRIA2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium	45.49	68	9246466 (6), 9849678 (4), 9236229 (4), 8616634 (3) (see all 29)
inosine	32.99	2	7878468 (1), 9149227 (1)
hydrogen	0.00	2	11388900 (1)
oligonucleotide	0.00	1	7609609 (1)
zinc	0.00	8	15525775 (3), 8015375 (1)
tyrosine	0.00	11	14976558 (4), 17534972 (2), 15240807 (2), 11425507 (1)
arachidonic acid	0.00	2	10101246 (1), 18713832 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GRIA2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GRIA2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001083619

Sigma-Aldrich siRNA and siRNA Panels for GRIA2

Sigma-Aldrich shRNA for GRIA2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000826 NM_001083619 NM_001083620

REFSEQ mRNAs for GRIA2 gene (3 alternative transcripts):

NM_000826.3 NM_001083619.1 NM_001083620.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000826 NM_001083619 NM_001083620

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000826
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000826
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_000826

Additional cDNA sequence:

AB209567.1 AK294458.1 AK308775.1 AK309067.1 BC010574.1 BC028736.1 FJ460422.1 FJ460423.1

FJ460424.1 FJ460425.1 FJ460426.1 FJ460427.1 FJ460428.1 FJ460429.1 FJ460430.1 FJ460431.1

FJ460432.1 L20814.1 X64829.1 X64830.1

10 DOTS entries:

DT.412775 DT.75100690 DT.75100845 DT.40118112 DT.95130075 DT.40296098 DT.40118111 DT.121266665

DT.121266666 DT.91843633

24/79 AceView cDNA sequences (see all 79 ):

AI421661 BQ271776 AI422996 AI687064 AI939470 BX951367 CA946928 AI963223

BX645164 BX951591 CB143535 BM510013 CA946925 AI955511 BC028736 AL119939

BM503870 AL703417 NM_000826 AI423358 BX478848 D54324 BE219628 CA942348

highest scoring ESTs for GRIA2:

AI687064 L20814 AA021212 AA916848 AI458995 AI499702 AI560619 AI564606 AI681410 AI687135

Unigene Cluster for GRIA2:

Glutamate receptor, ionotropic, AMPA 2

Hs.32763 [show with all ESTs]

Unigene Representative Sequence: NM_000826

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for GRIA2 (see all 6 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18a	·	18b	^	19	^	20
SP1:					-		-				-		-																								-		-
SP2:											-		-																								-		-
SP3:											-		-																												-		-
SP4:											-		-																								-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for GRIA2

4 Ensembl transcripts including schematic representations:

ENST00000323661 ENST00000393815 ENST00000296526 ENST00000264426

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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GRIA2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GRIA2

¹ / ² / ³

7 probe-sets matching GRIA2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
73227_r_at²^{, 3}	U95-D	1	1.00	1.00	0.91	0.83	AI955511	0.80	1.00	0.91	1
73450_at²^{, 3}	U95-D	1	1.00	1.00	0.98	1.36	AI687064	1.00	1.00	1.00	1
40746_at²^{, 3}	U95-A	1	1.00	1.00	0.94	0.90	L20814	1.00	1.00	1.00	1
205358_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000826	0.60	1.00	0.82	1
236538_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BE219628	0.80	1.00	0.91	1
205358_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
236538_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks GRIA2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTCTTACAAA

SOURCE GeneReport for Unigene cluster: Hs.32763
Expression variation in blood from EXPOLDB for GRIA2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GRIA2 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GRIA2¹	--	glutamate receptor, ionotropic, AMPA 2	96.21(n) 99.35(a)	482667 XM_539784.2 XP_539784.2
chimpanzee (Pan troglodytes)	GRIA2¹	--	glutamate receptor, ionotropic, AMPA 2	98.08(n) 98.47(a)	461570 XM_001141570.1 XP_001141570.1
rat (Rattus norvegicus)	Gria2¹	--	glutamate receptor, ionotropic, AMPA 2	92.6(n) 98.53(a)	29627 NM_017261.1 NP_058957.1
mouse (Mus musculus)	Gria2^{1, 5}	3 (33.60 cM)⁵	glutamate receptor, ionotropic, AMPA2 (alpha 2)^{1, 5}	93.88(n)¹ 99.77(a)¹	14800¹ NM_013540.2¹ NP_038568.2¹ AB111957⁵ AF201345⁵ (see all 44)
chicken (Gallus gallus)	GRIA2¹	--	glutamate receptor, ionotropic, AMPA 2	87.05(n) 94.79(a)	414894 NM_001001775.1 NP_001001775.1

About this table Species with no ortholog for GRIA2

ENSEMBL Gene Tree for GRIA2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GRIA2 gene

GRIA4² GRIA3² GRIA1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/490 NCBI SNPs in GRIA2 are shown (see all 490 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 125)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs6849345^1,2	A,C,F,H	158359579(+)	`TAAATA/GCATTT`	3	--	ng5¹		4		EU EA WA	418
	rs6855973^1,2	A,C,F,H	158506065(+)	`CTAAAA/TATTGT`	3	--	ut3¹		8		EU EA WA	836
	rs4403097^1,2	A,C,F,H	158505047(+)	`ATATCT/CGAATA`	3	--	ut3¹ ese³		8		EU EA WA	776
	rs13113493^1,2	C,F,H	158507126(+)	`GTGTTA/GATGAG`	3	--	ng3¹		11		NA EU EA WA	972
	rs6850272^1,2	F,H	158359746(+)	`AGAGGG/TAAAGG`	3	--	ng5¹ trp³		4		EU EA WA	392
	rs6848829^1,2	F,H	158359209(+)	`AACATC/TAAATT`	2	--	ng5¹		4		EU EA WA	418
--	rs6826285^1,2	A	158359389(+)	`ATAGGG/TAATAA`	3	--	ng5¹ tfbs³		0	--	--	--	--
	rs10003571^1,2	H	158359642(+)	`TAAAAT/GTCTAA`	3	--	ng5¹ tfbs³		3		EU EA	276
	rs6827703^1,2	H	158505660(+)	`ATTTGT/AATTCT`	3	--	ut3¹		4		EU EA WA	372
	rs4302506^1,2	A,C,F,H	158458280(+)	`AAACAC/TGTTAA`	3	H/H	syn¹		4		EU EA WA	418

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HapMap Linkage Disequilibrium images for GRIA2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 138247

10/15 Novoseek disease relationships for GRIA2 gene (see all 15 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
amyotrophic lateral sclerosis	59.59	2	16042312 (1), 10589532 (1)
neurodegeneration	41.41	10	16042312 (2), 10531425 (2), 8182436 (2), 9246466 (1) (see all 5)
motor neuron disease	32.52	2	16523673 (2)
ischemia	30.02	27	11935066 (3), 8898712 (3), 9236229 (3), 12654500 (2) (see all 11)
status epilepticus	29.28	6	9825961 (3), 9246466 (1), 10531425 (1)
neurological disorders	24.83	3	9347614 (1), 10589532 (1)
schizophrenia	18.04	11	7609609 (3), 8616634 (2), 9030702 (2), 9099808 (1)
neurodegenerative diseases	11.77	1	17544687 (1)
brain diseases	8.33	1	7969894 (1)
epilepsy	6.47	3	9347614 (1), 7798948 (1)

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Human Genome Epidemiology Navigator: GRIA2 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/213 PubMed articles for GRIA2 gene (see all 213 ):

Primary structure and functional expression of the AMPA/kainate receptor subunit 2 from human brain. (PubMed id 8003671)^{1, 3, 4} Sun W.... Montal M. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue. (PubMed id 7523595)^{3, 4} Paschen W.... Ross C.A. (1994)
Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors. (PubMed id 1311100)^{2, 3} Sun W.... Montal M. (1992)
Human spinal motoneurons express low relative abundance of GluR2 mRNA: an implication for excitotoxicity in ALS. (PubMed id 12694394)^{1, 3} Kawahara Y....Kanazawa I. (2003)
Inhibition of glutamate receptor 2 translation by a polymorphic repeat sequence in the 5'-untranslated leaders. (PubMed id 15071096)^{1, 3} Myers S.J....Dingledine R. (2004)
Brain-derived neurotrophic factor regulates surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors by enhancing the N-ethylmaleimide-sensitive factor/GluR2 interaction in developing neocortical neurons. (PubMed id 12130635)^{1, 3} Narisawa-Saito M....Nawa H. (2002)
Low editing efficiency of GluR2 mRNA is associated with a low relative abundance of ADAR2 mRNA in white matter of normal human brain. (PubMed id 12859334)^{1, 3} Kawahara Y....Kwak S. (2003)
Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins. (PubMed id 11007883)^{1, 3} Chung H.J....Huganir R.L. (2000)
Phosphorylation of serine-880 in GluR2 by protein kinase C prevents its C terminus from binding with glutamate receptor-interacting protein. (PubMed id 10501226)^{1, 3} Matsuda S....Hirai H. (1999)

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Entrez Gene: 2891	HGNC: 4572	AceView: GRIA2	Ensembl:ENSG00000120251	euGenes: HUgn2891
ECgene: GRIA2	H-InvDB: GRIA2

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GRIA2 Gene

protein-coding GIFtS: 69

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for GRIA2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GRIA2 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor GRIA2

Summariesfor GRIA2

Genomic Locationfor GRIA2

Proteinsfor GRIA2

Protein Domains/Familiesfor GRIA2

Gene Functionfor GRIA2

Pathways & Interactionsfor GRIA2

Drugs & Compoundsfor GRIA2

Transcriptsfor GRIA2

Expression for GRIA2

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Medical Newsfor GRIA2

Publicationsfor GRIA2

Search for GRIA2

Genome Databases showing GRIA2

Other Databases showing GRIA2

Specialized Databases showing GRIA2

Licensable Technologiesfor GRIA2

Servicesfor GRIA2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GRIA2

Summaries
for GRIA2

Genomic Location
for GRIA2

Proteins
for GRIA2

Protein Domains/
Families
for GRIA2

Gene Function
for GRIA2

Pathways & Interactions
for GRIA2

Drugs & Compounds
for GRIA2

Transcripts
for GRIA2

Expression
for GRIA2

Orthologs
for GRIA2

Paralogs
for GRIA2

SNPs/Variants
for GRIA2

Disorders & Mutations
for GRIA2

Medical News
for GRIA2

Publications
for GRIA2

Licensable Technologies
for GRIA2

Services
for GRIA2