GRIA2 Gene
protein-coding GIFtS: 70
GCID: GC04P158141
|
|
glutamate receptor, ionotropic, AMPA 2
(Previous symbol: GLUR2)
| |
Aliases
for GRIA2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Glutamate Receptor, Ionotropic, AMPA 21 2 | | GluR-23 | | GLUR21 2 3 5 | | GluR-B3 | | GluA21 2 3 | | Glutamate Receptor 22 | | GLURB1 2 | | GluR-23 | | GluR-K22 3 | | GluR-B3 | | AMPA-Selective Glutamate Receptor 22 3 | | Glutamate Receptor Ionotropic, AMPA 23 | | HBGR22 | | |
Export aliases for GRIA2 gene to outside databasesPrevious GC identifers: GC04P159021 GC04P158572 GC04P158719 GC04P158499 GC04P158361 GC04P153892 |
Summaries
for GRIA2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GRIA2:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activatedin a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors thatare sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cationchannels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) issubject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render thechannel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function,and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology.Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flopisoforms that vary in their signal transduction properties), has been noted for this gene. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: GRIA2_HUMAN, P42262Function: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays animportant role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at manysynapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformationchange, leading to the opening of the cation channel, and thereby converts the chemical signal to an electricalimpulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presenceof bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by adelayed accumulation of current flux upon continued application of glutamate
 summary
for GRIA2: AMPA receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and
kainate receptors. AMPA receptors mediate fast excitatory synaptic transmission in the CNS and play a key
role in hippocampal synaptic long-term potentiation (LTP) and depression (LTD). AMPA receptors consist of
GluR1-4 subunits which assemble as homomers or heteromers to form functional AMPA receptors. The subunit
composition determines the physiological properties of AMPA receptors: those containing the GluR2 subunit
show low permeability to Ca2+ whereas those lacking this subunit show high Ca2+ permeability.
Gene Wiki entry for GRIA2
|
Genomic Views
for GRIA2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GRIA2 gene promoter:
p53 Chx10 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU6F1 (c2) POU3F2
Other transcription factors
Search SABiosciences Chromatin IP Primers for GRIA2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRIA2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q32.1 Ensembl cytogenetic band: 4q32.1 HGNC cytogenetic band: 4q32.1GRIA2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P158141: view genomic region
(about GC identifiers)
Start:
|
158,125,334 bp from pter |
End:
|
158,287,227 bp from pter |
Size:
|
161,894 bases |
Orientation:
|
plus strand |
|
Proteins
for GRIA2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GRIA2_HUMAN, P42262 (See
protein sequence)Recommended Name: Glutamate receptor 2 precursor Size: 883 amino acids; 98821 Da
Subunit: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by thedimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4. Interacts with ATAD1 inan ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts binding to ATAD1 and to GRIP1 and leads to AMPARcomplex disassembly (By similarity). Interacts with PICK1 (via PDZ domain). Interacts with PRKCABP and GRIP2 (Bysimilarity). Interacts with GRIA1 and SYNDIG1 (By similarity). Interacts with LRFN1 (By similarity). Found in acomplex with GRIA1, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts withCACNG5 (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membraneprotein (By similarity). Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression (By similarity)
Rna editing: Modified_positions=607; Note=Partially edited. Fully edited in the brain. Heteromerically expressed editedGLUR2 (R) receptor complexes are impermeable to calcium, whereas the unedited (Q) forms are highly permeable todivalent ions
Miscellaneous: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to theirselective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate
6/7 PDB 3D structures from  and Proteopedia  for GRIA2 (see all 7):2WJW (3D)
2WJX (3D)
2XHD (3D)
3R7X (3D)
3RN8 (3D)
3RNN (3D)
Secondary accessions: Q96FP6Alternative splicing: 3 isoforms: P42262-1 P42262-2 P42262-3 Explore the universe of human proteins at neXtProt for GRIA2: NX_P42262
Post-translational modifications:
Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention anddecreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression butregulates stimulation-dependent endocytosis (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P42262
GRIA2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_000817.2 NP_001077088.1 NP_001077089.1
ENSEMBL proteins: ENSP00000423988 ENSP00000426845 ENSP00000377403 ENSP00000425217 ENSP00000296526 ENSP00000264426 ENSP00000426513 ENSP00000318144 ENSP00000422038 ENSP00000426784 ENSP00000423229 ENSP00000389837 Reactome Protein details: P42262
Human Recombinant Protein Products:
Gene Ontology (GO): 5/22 cellular component terms (GO ID links to tree view) (see all 22): About this table
GRIA2 for ontologies About GeneDecksing
GRIA2 Antibody Products:
Assay Products for GRIA2: |
Protein
Domains /
Families
for GRIA2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GRIA2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P42262ProtoNet protein and cluster: P42262 3 Blocks protein families: IPB001320 Ionotropic glutamate receptor IPB001508 NMDA receptor signature IPB001828 Extracellular ligand-binding receptor
UniProtKB/Swiss-Prot: GRIA2_HUMAN, P42262Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily |
Function
for GRIA2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GRIA2_HUMAN, P42262Function: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays animportant role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at manysynapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformationchange, leading to the opening of the cation channel, and thereby converts the chemical signal to an electricalimpulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presenceof bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by adelayed accumulation of current flux upon continued application of glutamate Genatlas biochemistry entry for GRIA2:glutamate receptor,subunit 2,ionotropic,AMPA (amino-3-hydroxy 5 methyl-isoxazole-propionic) class,with flip and flopisoforms,mediating the fast component of excitatory post synaptic currents in the central nervous system,interactingwith and signaling through the protein-kinase LYN
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIA2 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004970 | ionotropic glutamate receptor activity |
IDA | -- | | GO:0004971 | alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity |
ISS | -- | | GO:0005234 | extracellular-glutamate-gated ion channel activity |
IEA | -- | | GO:0008066 | glutamate receptor activity |
TAS | 1311100 | | GO:0015277 | kainate selective glutamate receptor activity |
ISS | -- |
GRIA2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for GRIA2:
Animal Models:
Mouse knock-outs for GRIA2: Gria2tm1Rod Gria2tm2.1Rsp Gria2tm1Ksak Gria2tm2Rsp Gria2tm1Rsp Gria2tm1Sans
Gria2tm1Rlh Gria2tm3.1Rsp
11 MGI mutant phenotypes (inferred from 12 alleles ) (MGI details for Gria2):
GRIA2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for GRIA2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity | | | 2 | Transmission across Chemical Synapses | | | 3 | Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling | | | 4 | Pathogenesis of ALS | | | 5 | CREB Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for GRIA2
5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GRIA2
2 
Cell Signaling Technology (CST) Pathways for GRIA2
1  GeneGo (Thomson Reuters) Pathway for GRIA2
2  BioSystems Pathways for GRIA2
5/9 
Reactome Pathways for GRIA2 (see all 9)
5 
Kegg Pathways (Kegg details for GRIA2):
GRIA2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRIA2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/73 Interacting proteins for GRIA2 (P422622, 3 ENSP000002644264) via UniProtKB, MINT, STRING, and/or I2D (see all 73)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
GRIA2 for ontologies About GeneDecksing
|
Drugs & Compounds
for GRIA2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
GRIA2 for compounds About GeneDecksing
Compounds for GRIA2 available from Tocris Bioscience About this table
1 HMDB Compound for GRIA2 About this table
10/38 DrugBank Compounds for GRIA2 (see all 38) About this table
10/20 Novoseek chemical compound relationships for GRIA2 gene (see all 20) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid |
86.1 |
16 |
8003671 (1), 10101246 (1), 7878468 (1), 12654500 (1) (see all 14) |
| glutamate |
83.3 |
122 |
15100219 (2), 8968949 (2), 10501226 (2), 19729452 (2) (see all 80) |
| kainate |
78.6 |
47 |
16701950 (6), 8003671 (3), 9849678 (3), 11388900 (2) (see all 22) |
| cyclothiazide |
74.3 |
3 |
9166736 (1), 7511109 (1), 19673491 (1) |
| nmda |
71.4 |
33 |
18077702 (3), 19279258 (3), 19644508 (2), 15996549 (2) (see all 16) |
| dnqx |
59 |
1 |
20155979 (1) |
| cnqx |
55.6 |
2 |
11388900 (1) |
| aniracetam |
50.8 |
2 |
11834304 (1) |
| calcium |
45.4 |
74 |
9246466 (6), 9849678 (4), 9236229 (4), 8616634 (3) (see all 32) |
| inosine |
39.3 |
2 |
7878468 (1), 9149227 (1) |
Search CenterWatch for drugs/clinical trials and news about GRIA2
|
Transcripts
for GRIA2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GRIA2 gene (3 alternative transcripts): NM_000826.3 NM_001083619.1 NM_001083620.1 Unigene Cluster for GRIA2: Glutamate receptor, ionotropic, AMPA 2 Hs.32763 [show with all ESTs]Unigene Representative Sequence: NM_00082615 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000504801 ENST00000512774 ENST00000507898 ENST00000393815(uc003ipk.4)
ENST00000509417 ENST00000296526(uc021xtr.1 uc003ipm.4 uc003ipl.4)
ENST00000471736 ENST00000264426(uc011civ.1 uc011ciw.1) ENST00000506284
ENST00000323661(uc010iqh.1 uc011ciu.1) ENST00000505888 ENST00000503437
ENST00000510854(uc011cix.1 uc011ciy.1 uc011ciz.1) ENST00000503980
ENST00000449365(uc011cit.2)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRIA2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): GRIA2 (NM_000826) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GRIA2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRIA2 |
Additional cDNA sequence: AB209567.1 AK294458.1 AK308775.1 AK309067.1 BC010574.1 BC028736.1 FJ460422.1 FJ460423.1 FJ460424.1 FJ460425.1 FJ460426.1 FJ460427.1 FJ460428.1 FJ460429.1 FJ460430.1 FJ460431.1 FJ460432.1 JN547408.1 L20814.1 X64829.1 X64830.1 10 DOTS entries: DT.412775 DT.75100690 DT.75100845 DT.40118112 DT.95130075 DT.40296098 DT.121266665 DT.121266666 DT.40118111 DT.91843633 24/79 AceView cDNA sequences (see all 79): CB143535 BX645164 AI422996 AI687064 CA946925 BM510013 AI939470 CA946928 BX951367 BQ271776 AI421661 AI963223 BX951591 BC010574 AI560619 BX952214 BE219628 BC028736 NM_000826 BM503870 BG913868 D54324 L20814 BE466973
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for GRIA2 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 |
|---|
|
| SP1: | | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for GRIA2
|
Expression
for GRIA2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GRIA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTTACAAA
About this image
See GRIA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GRIA2
SOURCE GeneReport for Unigene cluster: Hs.32763
SABiosciences Expression via Pathway-Focused PCR Arrays including GRIA2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GRIA2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIA2 |
Orthologs
for GRIA2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for GRIA2 gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
GRIA21 |
glutamate receptor, ionotropic, AMPA 2 |
88.41(n)
95.92(a) |
|
414894 NM_001001775.3 NP_001001775.2 |
lizard
(Anolis carolinensis) |
Reptilia |
GRIA26 |
-- |
88(a) |
1 ↔ 1 |
5(128788267-128831868) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.85832 |
Xenopus laevis transcribed sequence with strong similarity more |
86.34(n) |
|
CD324781.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
gria2.22 |
glutamate receptor, ionotropic, AMPA 2.2 |
76.29(n) |
|
170451 AF525744.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG111553 |
kainate selective glutamate receptor |
51(a)
(best of 8) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
glr-13 |
Expression: neurons, RMD neurons, SMD
neurons, more |
38(a)
(best of 2) |
|
III(8655978-8660337) -- |
ENSEMBL Gene Tree for GRIA2 (if available)
TreeFam Gene Tree for GRIA2 (if available) |
Paralogs
for GRIA2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GRIA2 gene
- GRIA32 GRIN2D2 GRIK12 GRIK22 GRIN12 GRIA12 GRIK42 GRIK32
- GRIN3A2 GRIN2B2 GRIN2A2 GRIK52 GRIN3B2 GRIN2C2 GRIA42 GRID12
- GRID22
11 SIMAP similar genes for GRIA2 using alignment to 11 protein entries: GRIA2_HUMAN (see all proteins):GluR4c GRIA1 GRIA3 GRIA4 GRIK2 GRIK3
GRIK1 GRIK4 GRIK5 GRID2 GRID1
GRIA2 for paralogs About GeneDecksing
|
Genomic Variants
for GRIA2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for GRIA2
4 CNVs: 3520 2551 92490 80534 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GRIA2 |
|
Disorders
/ Diseases
for GRIA2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GRIA2 for disorders About GeneDecksing
OMIM gene information: 138247
OMIM disorders: --
20/28  diseases for GRIA2 (see all 28): About MalaCardsamyotrophic lateral sclerosis (als) amyotrophic lateral sclerosis lateral sclerosis status epilepticus
temporal lobe epilepsy motor neuron disease intractable epilepsy alcohol abuse
anorexia nervosa tetanus neurodegenerative disease mood disorder
brain disease bipolar disorder neuroendocrine carcinoma embryonal carcinoma
alzheimer's disease ischemia neurodegeneration multiple sclerosis
2 diseases from the University of Copenhagen DISEASES database for GRIA2:Amyotrophic lateral sclerosis Schizophrenia 10/15 Novoseek disease relationships for GRIA2 gene (see all 15) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| amyotrophic lateral sclerosis |
60.1 |
2 |
16042312 (1), 10589532 (1) |
| neurodegeneration |
43.6 |
11 |
16042312 (2), 10531425 (2), 8182436 (2), 20153402 (1) (see all 6) |
| motor neuron disease |
30.2 |
2 |
16523673 (2) |
| ischemia |
27.7 |
27 |
11935066 (3), 8898712 (3), 9236229 (3), 12654500 (2) (see all 11) |
| status epilepticus |
26.8 |
6 |
9825961 (3), 9246466 (1), 10531425 (1) |
| neurological disorders |
26.2 |
3 |
9347614 (1), 10589532 (1) |
| neurodegenerative diseases |
23.5 |
1 |
17544687 (1) |
| schizophrenia |
21.8 |
11 |
7609609 (3), 8616634 (2), 9030702 (2), 9099808 (1) |
| epilepsy |
9.05 |
4 |
20188170 (1), 9347614 (1), 7798948 (1) |
| glioblastoma |
8.27 |
2 |
12172541 (1), 19618852 (1) |
Human Genome Epidemiology (HuGE) Navigator: GRIA2 (8 documents)
Export disorders for GRIA2 gene to outside databases
|
Publications
for GRIA2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GRIA2 gene, integrated from 9 sources (see all 289):
(articles sorted by number of sources associating them with GRIA2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Primary structure and functional expression of the AMPA/kainate receptor subunit 2 from human brain. (PubMed id 8003671)1, 2, 9 Sun W.... Montal M. (1994)
- Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate re ceptors. (PubMed id 19651138)1, 2, 9 Clayton A....Aricescu A.R. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Glutamatergic plasticity by synaptic delivery of GluR-B(long)- containing AMPA receptors. (PubMed id 14687553)1, 2 Kolleker A.... Osten P. (2003)
- RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue. (PubMed id 7523595)1, 2 Paschen W.... Ross C.A. (1994)
- Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors. (PubMed id 1311100)1, 3 Sun W.... Montal M. (1992)
- PICK1 targets activated protein kinase Calpha to AMPA receptor clusters in spines of hippocampal neurons and reduces surface levels of the AMPA-type glutamate receptor subunit 2. (PubMed id 11466413)1, 9 Perez J.L....Ziff E.B. (2001)
- The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligands. (PubMed id 15247289)2, 9 Dev K.K.... Henley J.M. (2004)
- Human spinal motoneurons express low relative abundance of GluR2 mRNA: an implication for excitotoxicity in ALS. (PubMed id 12694394)1, 9 Kawahara Y....Kanazawa I. (2003)
- PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking. (PubMed id 16055064)1, 9 Lu W. and Ziff E.B. (2005)
|
External Searches for GRIA2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GRIA2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GRIA2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GRIA2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GRIA2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GRIA2 gene:
Search GeneIP for patents involving GRIA2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GRIA2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | OriGene Antibodies for GRIA2 | | OriGene shRNA RFP for GRIA2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GRIA2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GRIA2 | | | OriGene Protein Over-expression Lysate for GRIA2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GRIA2 | | OriGene 3'-UTR Clone for GRIA2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRIA2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRIA2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Tocris compounds for GRIA2 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIA2 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRIA2 |
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