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GRIA1 Gene

protein-coding   GIFtS: 72
GCID: GC05P152850

Glutamate Receptor, Ionotropic, AMPA 1


(Previous symbol: GLUR1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutamate Receptor, Ionotropic, AMPA 11 2     gluR-12
GLUR11 2 3 5     gluR-A2
GLUH12 3     gluR-K12
GluA12 3     Glutamate Receptor 12
AMPA-Selective Glutamate Receptor 12 3     GluR-13
GLURA2     GluR-A3
HBGR12     GluR-K13
AMPA 12     Glutamate Receptor Ionotropic, AMPA 13

External Ids:    HGNC: 45711   Entrez Gene: 28902   Ensembl: ENSG000001555117   OMIM: 1382485   UniProtKB: P422613   

Export aliases for GRIA1 gene to outside databases

Previous GC identifers: GC05P152945 GC05P153467 GC05P152898 GC05P148010


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GRIA1 Gene:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are
activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes
with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion
channel. The classification of glutamate receptors is based on their activation by different pharmacologic
agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)
receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for GRIA1 Gene:
GRIA1 (glutamate receptor, ionotropic, AMPA 1) is a protein-coding gene. Diseases associated with GRIA1 include limbic encephalitis, and drug addiction. GO annotations related to this gene include PDZ domain binding and glutamate receptor activity. An important paralog of this gene is GRIA3.

UniProtKB/Swiss-Prot: GRIA1_HUMAN, P42261
Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in
the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change,
leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse.
The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of
bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a
delayed accumulation of current flux upon continued application of glutamate

summary for GRIA1 Gene:
AMPA receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and
kainate receptors. AMPA receptors mediate fast excitatory synaptic transmission in the CNS and play a key
role in hippocampal synaptic long-term potentiation (LTP) and depression (LTD). AMPA receptors consist of
GluR1-4 subunits which assemble as homomers or heteromers to form functional AMPA receptors. The subunit
composition determines the physiological properties of AMPA receptors: those containing the GluR2 subunit
show low permeability to Ca2+ whereas those lacking this subunit show high Ca2+ permeability.

Gene Wiki entry for GRIA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_029289.12  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GRIA1 gene promoter:
         AML1a   FOXF2   NF-kappaB   MZF-1   FOXO4   FOXJ2 (long isoform)   NF-kappaB2   aMEF-2   FOXJ2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRIA1 promoter sequence
   Search Chromatin IP Primers for GRIA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRIA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q33.2   HGNC cytogenetic band: 5q33

GRIA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRIA1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P152850:  view genomic region     (about GC identifiers)

Start:
152,869,175 bp from pter      End:
153,193,429 bp from pter
Size:
324,255 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GRIA1_HUMAN, P42261 (See protein sequence)
Recommended Name: Glutamate receptor 1 precursor  
Size: 906 amino acids; 101506 Da
Subunit: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by
the dimerization of dimers. Interacts with DLG1 via its C-terminus. Found in a complex with GRIA2, GRIA3, GRIA4,
CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with HIP1, RASGRF2, SYNDIG1 and LRFN1.
Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when
endocytosed and prevent degradation in lysosomes. Interacts (via PDZ-binding motif) with SHANK3 (via PDZ domain)
Miscellaneous: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to
their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate
Secondary accessions: B7Z2S0 B7Z2W8 B7Z3F6 B7Z9G9 D3DQI4 E7ESV8 Q2NKM6
Alternative splicing: 6 isoforms:  P42261-1   P42261-2   P42261-3   P42261-4   P42261-5   P42261-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GRIA1: NX_P42261

Explore proteomics data for GRIA1 at MOPED

Post-translational modifications: 

  • Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and
    decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression
    but regulates stimulation-dependent endocytosis (By similarity)1
  • Glycosylation2 at Asn63, Asn249, Asn257, Asn363, Asn401, Asn406
  • Modification sites at PhosphoSitePlus

  • See GRIA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_000818.2  NP_001107655.1  NP_001244948.1  NP_001244949.1  NP_001244950.1  NP_001244951.1  NP_001244952.1  

    ENSEMBL proteins: 
     ENSP00000285900   ENSP00000427920   ENSP00000339343   ENSP00000427864   ENSP00000415569  
     ENSP00000428994  
    Reactome Protein details: P42261

    GRIA1 Human Recombinant Protein Products:

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    OriGene Purified Protein for GRIA1
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    Novus Biologicals GRIA1 Protein
    Novus Biologicals GRIA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GRIA1

    GRIA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GRIA1
    R&D Systems Antibodies for GRIA1 (GluR1)
    Cell Signaling Technology (CST) Antibodies for GRIA1  (GluR1)
    OriGene Antibodies for GRIA1
    OriGene Custom Antibody Services for GRIA1
    Novus Biologicals GRIA1 Antibodies
    Abcam antibodies for GRIA1
    Cloud-Clone Corp. Antibodies for GRIA1
    ThermoFisher Antibodies for GRIA1
    LSBio Antibodies in human, mouse, rat for GRIA1

    GRIA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GRIA1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GRIA1
    Cloud-Clone Corp. CLIAs for GRIA1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GRI: Ligand-gated ion channels / Glutamate receptors, ionotropic
    GR: Glutamate receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GluA1
    Ionotropic glutamate receptors

    5 InterPro protein domains:
     IPR028082 Peripla_BP_I
     IPR019594 Glu_rcpt_Glu/Gly-bd
     IPR001320 Iontro_glu_rcpt
     IPR001828 ANF_lig-bd_rcpt
     IPR001508 NMDA_rcpt

    Graphical View of Domain Structure for InterPro Entry P42261

    ProtoNet protein and cluster: P42261

    3 Blocks protein domains:
    IPB001320 Ionotropic glutamate receptor
    IPB001508 NMDA receptor signature
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GRIA1_HUMAN, P42261
    Domain: The M4 transmembrane segment mediates tetramerization and is required for cell surface expression
    Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily


    GRIA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRIA1_HUMAN, P42261
    Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in
    the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change,
    leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse.
    The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of
    bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a
    delayed accumulation of current flux upon continued application of glutamate

         Genatlas biochemistry entry for GRIA1:
    glutamate receptor,subunit 1,ionotropic,AMPA (amino-3-hydroxy 5 methyl-isoxazole-propionic) class,with flip and
    flop isoforms,mediating the fast component of excitatory post synaptic currents in the central nervous
    system,interacting with and signaling through the protein-kinase LYN

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004970ionotropic glutamate receptor activity ----
    GO:0004971alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity IDA--
    GO:0005215transporter activity ----
    GO:0005234extracellular-glutamate-gated ion channel activity IBA--
    GO:0005515protein binding IPI--
         
    GRIA1 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Gria1):
     behavior/neurological  growth/size/body  homeostasis/metabolism  integument  nervous system 
     no phenotypic analysis  normal 

    GRIA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GRIA1: Gria1tm2Rlh Gria1tm3Rlh Gria1tm1Ksak Gria1tm1Rsp

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRIA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GRIA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRIA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GRIA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target GRIA1:
    hsa-mir-335-5p (MIRT018501), hsa-mir-192-5p (MIRT004156)

    Block miRNA regulation of human, mouse, rat GRIA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GRIA1 (see all 67):
    hsa-miR-576-3p hsa-miR-579 hsa-miR-300 hsa-miR-128 hsa-miR-3653 hsa-miR-578 hsa-miR-138-2* hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidGRIA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GRIA1
    Predesigned siRNA for gene silencing in human, mouse, rat GRIA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GRIA1

    Clone
    Products:
         
    OriGene clones in human, mouse for GRIA1 (see all 11)
    OriGene ORF clones in mouse, rat for GRIA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GRIA1 (NM_000827)
    Sino Biological Human cDNA Clone for GRIA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRIA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRIA1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GRIA1_HUMAN, P42261: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass
    membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane
    protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell
    projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Note=Interaction with
    CACNG2, CNIH2 and CNIH3 promotes cell surface expression (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    cytoskeleton4
    extracellular2
    nucleus2
    endosome1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005886plasma membrane TAS--
    GO:0008021synaptic vesicle IEA--
    GO:0008328ionotropic glutamate receptor complex ----

    GRIA1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GRIA1 About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1Amyotrophic lateral sclerosis (ALS)
    Amyotrophic lateral sclerosis (ALS)0.63
    Pathogenesis of ALS0.31
    Amyotrophic lateral sclerosis (ALS)0.63
    2Post NMDA receptor activation events
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.90
    Unblocking of NMDA receptor, glutamate binding and activation0.00
    Long-term potentiation0.35
    3Trafficking of AMPA receptors
    Trafficking of AMPA receptors1.00
    Trafficking of GluR2-containing AMPA receptors0.00
    Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity1.00
    Activation of AMPA receptors0.00
    4Circadian entrainment
    Retrograde endocannabinoid signaling0.51
    Glutamatergic synapse0.39
    Circadian entrainment0.40
    Dopaminergic synapse0.37
    5Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GRIA1
        Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Pathogenesis of ALS
    CREB Pathway
    Intracellular Calcium Signaling
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    1 Cell Signaling Technology (CST) Pathway for GRIA1
        Neuroscience

    1 GeneGo (Thomson Reuters) Pathway for GRIA1
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    4 BioSystems Pathways for GRIA1
        Hypothetical Network for Drug Addiction
    BDNF signaling pathway
    Amyotrophic lateral sclerosis (ALS)
    EPHB forward signaling


    4 Reactome Pathways for GRIA1
        Unblocking of NMDA receptor, glutamate binding and activation
    Trafficking of AMPA receptors
    Trafficking of GluR2-containing AMPA receptors
    Activation of AMPA receptors


    Selected Kegg Pathways  (Kegg details for GRIA1) (see all 10):
        Neuroactive ligand-receptor interaction
    Circadian entrainment
    Long-term potentiation
    Retrograde endocannabinoid signaling
    Glutamatergic synapse


    GRIA1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRIA1: 
              Neurotransmitter Receptors in human mouse rat
              GABA & Glutamate in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GRIA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GRIA1 (P422612, 3 ENSP000002859004) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CXCR2P250252, 3, ENSP000003196354MINT-49811 I2D: score=2 STRING: ENSP00000319635
    PRKACAP176122, 3, ENSP000003095914MINT-18147 I2D: score=2 STRING: ENSP00000309591
    GRIA2P422623, ENSP000002644264I2D: score=8 STRING: ENSP00000264426
    SDCBPO005603, ENSP000002601304I2D: score=4 STRING: ENSP00000260130
    GRIA4P480583, ENSP000002824994I2D: score=3 STRING: ENSP00000282499
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0007165signal transduction TAS1311100
    GO:0007268synaptic transmission TAS--
    GO:0007616long-term memory IEA--
    GO:0031623receptor internalization IEA--

    GRIA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for GRIA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CNQX disodium saltPotent AMPA/kainate antagonist. More water soluble form of CNQX (Cat. No. 0190)[115066-14-3]
    Naspm trihydrochlorideCa2+-permeable AMPA receptor antagonist[122306-11-0]
    NBQXPotent AMPA antagonist. More selective than CNQX (Cat. No. 0190)[118876-58-7]
    DNQX disodium saltSelective non-NMDA antagonist. Water-soluble salt of DNQX (Cat. No. 0189)[2379-57-9]
    NBQX disodium saltPotent AMPA antagonist. More water soluble form of NBQX (Cat. No. 0373)[118876-58-7]

    7 DrugBank Compounds for GRIA1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--1279377 7679210 7838123 17139284 17016423
    DesfluraneDesflurano [INN-Spanish] (see all 2)57041-67-5targetantagonist17139284 17016423 8786535
    MethoxyfluraneMethoflurane (see all 11)76-38-0targetantagonist17139284 7702639 17016423
    Isoflurane-- 26675-46-7targetantagonist8786535 17207582
    SevofluraneSevofluran (see all 3)28523-86-6targetantagonist17139284 17016423
    EnfluraneAnesthetic 347 (see all 7)13838-16-9targetantagonist8786535
    PerampanelE-2007 (see all 2)380917-97-5targetantagonist21635236

    Selected IUPHAR Ligands for GRIA1 (GluA1) (see all 21)    About this table
    LigandTypeActionAffinityPubmed IDs
    S18986
    Allosteric regulatorPositive--
    LY392098
    Allosteric regulatorPositive--
    CX546
    Allosteric regulatorPositive--
    CX516
    Allosteric regulatorPositive--
    argiotoxin
    Channel blockerNone--
    joro toxin
    Channel blockerNone--
    piracetam
    Allosteric regulatorPositive--
    [3H]CNQX
    NoneNone--
    ATPO
    AntagonistAntagonist--
    GYKI53655
    AntagonistAntagonist--

    Selected Novoseek inferred chemical compound relationships for GRIA1 gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid 87.4 12 10101246 (1), 19338055 (1), 19261706 (1), 16246117 (1) (see all 10)
    glutamate 85.1 112 9832144 (3), 9120436 (2), 12763242 (2), 8873866 (2) (see all 90)
    kainate 81 39 8786535 (3), 8133291 (2), 9120436 (2), 9729352 (2) (see all 24)
    nmda 76.2 38 18045915 (3), 15519688 (3), 9674563 (2), 9618545 (2) (see all 23)
    cyclothiazide 63.2 3 15009673 (1), 7511109 (1)
    calcium 40.3 22 9106453 (3), 9191113 (2), 11943807 (2), 1372254 (1) (see all 13)
    k252a 34.4 5 17337442 (1), 15519688 (1)
    guanylate 25.1 1 11567040 (1)
    gaba 21.1 3 9618545 (1), 10235640 (1)
    picrotoxin 13.6 2 9618545 (1), 14659507 (1)



    GRIA1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GRIA1 gene (7 alternative transcripts): 
    NM_000827.3  NM_001114183.1  NM_001258019.1  NM_001258020.1  NM_001258021.1  NM_001258022.1  NM_001258023.1  

    Unigene Cluster for GRIA1:

    Glutamate receptor, ionotropic, AMPA 1
    Hs.519693  [show with all ESTs]
    Unigene Representative Sequence: NM_001258020
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481559(uc010jia.1) ENST00000520353 ENST00000518862 ENST00000285900(uc003lva.4 uc003luy.4 uc003luz.4 uc011dcv.2 uc011dcw.2)
    ENST00000474198 ENST00000518142 ENST00000340592 ENST00000517469 ENST00000521843
    ENST00000448073 ENST00000518783(uc011dcx.2 uc011dcy.2 uc011dcz.2)
    ENST00000492291 ENST00000520966
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    hsa-miR-576-3p hsa-miR-579 hsa-miR-300 hsa-miR-128 hsa-miR-3653 hsa-miR-578 hsa-miR-138-2* hsa-miR-502-3p
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    Additional mRNA sequence: 

    AB209094.1 AK289565.1 AK294011.1 AK294773.1 AK295039.1 AK295184.1 AK295827.1 AK310189.1 
    AK315934.1 BC111734.1 FJ947077.1 FJ947078.1 M64752.1 M81886.1 NR_047578.1 X58633.1 

    7 DOTS entries:

    DT.91694020  DT.91694012  DT.100745104  DT.120883509  DT.216973  DT.91694015  DT.120883502 

    Selected AceView cDNA sequences (see all 90):

    F09838 AI160145 Z39984 BE551874 AW450563 AI371990 F07524 T31307 
    AL120214 F03756 CB054445 AL707273 CA438561 BE222984 F12208 AW236612 
    AV718331 AL538420 BM546462 BE702011 F09808 AI193913 AL567302 F12617 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GRIA1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c
    SP1:                                                                                                  -                                 
    SP2:                          -                                                                             -                           
    SP3:                          -                                                                       -                                 


    ECgene alternative splicing isoforms for GRIA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GRIA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCGGATAAA
    GRIA1 Expression
    About this image


    GRIA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
    GRIA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GRIA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.519693

    UniProtKB/Swiss-Prot: GRIA1_HUMAN, P42261
    Tissue specificity: Widely expressed in brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRIA1: 
              Neurotransmitter Receptors in human mouse rat
              GABA & Glutamate in human mouse rat
              Synaptic Plasticity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GRIA1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gria11 , 5 glutamate receptor, ionotropic, AMPA1 (alpha 1)1, 5 90.03(n)1
    98.12(a)1
      11 (34.51 cM)5
    147991  NM_001113325.21  NP_001106796.11 
     570113875 
    chicken
    (Gallus gallus)
    Aves GRIA11 glutamate receptor, ionotropic, AMPA 1 84.04(n)
    94.01(a)
      414893  NM_001001774.1  NP_001001774.1 
    lizard
    (Anolis carolinensis)
    Reptilia GRIA16
    glutamate receptor, ionotropic, AMPA 1
    87(a)
    1 ↔ 1
    GL343248.1(1522792-1851002)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gria11 glutamate receptor, ionotropic, AMPA 1 77.12(n)
    88.14(a)
      100127569  XM_002941490.2  XP_002941536.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF525742.12   -- 77.18(n)    AF525742.1 


    ENSEMBL Gene Tree for GRIA1 (if available)
    TreeFam Gene Tree for GRIA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GRIA1 gene
    GRIA32  GRIK52  GRIK12  GRIA22  GRIA42  GRIK22  GRID12  GRIK32  
    GRIK42  GRID22  
    9 SIMAP similar genes for GRIA1 using alignment to 2 protein entries:     GRIA1_HUMAN (see all proteins):
    GRIA2    GRIA4    GRIA3    GRIK2    GRIK1    GRIK3
    GRID2    GRIK5    GRIK4

    GRIA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GRIA1 (see all 6600)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs674917241,2
    C--148110735(-) TTGTA-/ACACAC
    ACACACAC
    ACACA
    8 -- int11Minor allele frequency- ACACACACACACAC:0.00NA 2
    rs669559591,2
    C--148171607(+) ATTAG-/CAGGATTT 8 -- int10--------
    rs1854848501,2
    --152868388(+) TTCCTA/GTGCTG 5 -- us2k10--------
    rs5482941,2
    C,F,O,A,H--152868437(-) TAATAG/ACAGCA 5 -- us2k136Minor allele frequency- A:0.33NS EA NA WA CSA 3085
    rs774054071,2
    F--152868503(+) CCAATC/GTCTTT 5 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1482535051,2
    --152868577(+) TGAGGA/CTACCT 5 -- us2k10--------
    rs1127303141,2
    C,F--152868586(+) CTACAC/TAGGTA 5 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1503796811,2
    --152868648(+) TCAAAA/GTAGTG 5 -- us2k10--------
    rs1380912551,2
    --152868830(+) TGATAC/TACAGT 5 -- us2k10--------
    rs1419626341,2
    --152868956(+) TCCTGA/GATCAT 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for GRIA1 (152869175 - 153119175 bp, first 250kb of GRIA1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GRIA1 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657105CNV Deletion23128226
    esv2730932CNV Deletion23290073
    esv2674452CNV Deletion23128226
    esv2730933CNV Deletion23290073
    esv5069CNV Deletion18987735
    esv2677751CNV Deletion23128226
    esv271709CNV Insertion20981092
    nsv507300CNV Insertion20534489
    nsv883054CNV Loss21882294
    nsv883055CNV Loss21882294

    Human Gene Mutation Database (HGMD): GRIA1
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 138248    OMIM disorders: --

    Selected diseases for GRIA1 (see all 32):    
    About MalaCards
    limbic encephalitis    drug addiction    nicotine addiction    fragile x syndrome
    alcohol abuse    status epilepticus    toxic encephalopathy    brain disease
    bipolar disorder    tetanus    lateral sclerosis    amyotrophic lateral sclerosis
    albinism    temporal lobe epilepsy    mood disorder    major depressive disorder
    encephalitis    conjunctivitis    anorexia nervosa    migraine

    3 diseases from the University of Copenhagen DISEASES database for GRIA1:
    Schizophrenia     Toxic encephalopathy     Parkinson's disease

    GRIA1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for GRIA1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 27.6 10 10588576 (3), 7969894 (2), 7542540 (2), 9466422 (1) (see all 5)
    schizophrenia 24.4 12 17942280 (3), 16526023 (3), 7609609 (2), 9099808 (1) (see all 5)
    bipolar disorder 21.9 2 17942280 (1), 18484081 (1)
    epilepsy 21.4 4 9455976 (2), 8985700 (2)
    drug withdrawal 19 2 9832144 (1), 16616767 (1)
    neurofibrillary tangles 17.6 1 7542540 (1)
    brain diseases 16 2 7969894 (1), 7542540 (1)
    amyotrophic lateral sclerosis 15.4 1 8981413 (1)
    tumors 0.737 1 18957620 (1)
    ischemia 0 6 11935066 (2), 12606709 (2), 10674477 (1)

    Genetic Association Database (GAD): GRIA1
    Human Genome Epidemiology (HuGE) Navigator: GRIA1 (14 documents)

    Export disorders for GRIA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GRIA1 gene, integrated from 10 sources (see all 336):
    (articles sorted by number of sources associating them with GRIA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and chromosomal localization of one of the human glutamate receptor genes. (PubMed id 1652753)1, 2, 3 Puckett C.... Hood L.E. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    2. Glutamate AMPA receptor subunit 1 gene (GRIA1) and DSM-IV-TR schizophrenia: a pilot case-control association study in an Italian sample. (PubMed id 16526023)1, 4, 9 Magri C....Barlati S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006)
    3. Polymorphisms in the GRIA1 gene region in psychotic bipolar disorder. (PubMed id 18484081)1, 4, 9 Kerner B....Freimer N.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    4. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PubMed id 21658281)1, 4 Aouizerat B.E....Tseng Z.H. (BMC Cardiovasc Disord 2011)
    5. Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity. (PubMed id 20592726)1, 4 Chen S.H....Relling M.V. (Clin. Pharmacol. Ther. 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    8. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (J Psychiatr Res 2010)
    9. Common variants in the regulative regions of GRIA1 and GRIA3 receptor genes are associated with migraine susceptibility. (PubMed id 20579352)1, 4 Formicola D....Esposito T. (BMC Med. Genet. 2010)
    10. Genome-wide association study of anthropometric traits in Korcula Island, Croatia. (PubMed id 19260139)1, 4 Polasek O....Rudan I. (Croat. Med. J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 2890 HGNC: 4571 AceView: GRIA1 Ensembl:ENSG00000155511 euGenes: HUgn2890
    ECgene: GRIA1 Kegg: 2890 H-InvDB: GRIA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GRIA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for GRIA1 gene:
    Search GeneIP for patents involving GRIA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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