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GRIA1 Gene

protein-coding GIFtS: 69

GC05P152850

glutamate receptor, ionotropic, AMPA 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GLUR1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
GLUH1 ^², ³
GLUR1 ^², ³, ⁵
GLURA ^¹, ²
GluR-1 ^³
GluR-A ^³
GluR-K1 ^³
HBGR1 ^²
MGC133252 ^²

Descriptions
AMPA 1 ^²
AMPA-selective glutamate receptor 1 ^³
Glutamate receptor ionotropic, AMPA 1 ^³
glutamate receptor, ionotropic, AMPA 1 ^²

External Ids
HGNC: 4571¹
Entrez Gene: 2890²
UniProtKB: P42261³
Ensembl: ENSG00000155511⁷

Search outside databases for aliases for GRIA1 gene

Previous GC identifers: GC05P152945 GC05P153467 GC05P152898

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for GRIA1:

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian

brain and are activated in a variety of normal neurophysiologic processes. These receptors are

heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and

all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is

based on their activation by different pharmacologic agonists. This gene belongs to a family of

alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced

transcript variants encoding different isoforms have been found for this gene. [provided by

RefSeq]

UniProtKB/Swiss-Prot: GRIA1_HUMAN, P42261

Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many

synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate

induces a conformation change, leading to the opening of the cation channel, and thereby converts

the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a

transient inactive state, characterized by the presence of bound agonist

Gene Wiki entry for GRIA1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GRIA1 gene

Entrez Gene cytogenetic band: 5q33|5q31.1 Ensembl cytogenetic band: 5q33.2 HGNC cytogenetic band: 5q33

GRIA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P152850: (about GC identifiers)

Start:	152,850,499 bp from pter
End:	153,171,354 bp from pter
Size:	320,856 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_029289.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GRIA1_HUMAN, P42261 (See protein sequence)

Recommended Name: Glutamate receptor 1 precursor

Size: 906 amino acids; 101506 Da

Subunit: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may

be formed by the dimerization of dimers. Interacts with DLG1 via its C-terminus. Interacts with

CACNG2, HIP1 and RASGRF2 (By similarity)

Subcellular location: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane;

Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane;

Multi-pass membrane protein. Note=Interaction with CACNG2 promotes cell surface expression (By

similarity)

Miscellaneous: The postsynaptic actions of Glu are mediated by a variety of receptors that are

named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate >

kainate

Secondary accessions: Q2NKM6

Alternative splicing: 2 isoforms: P42261-1 P42261-2

Post-translational modifications:

Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi

retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not

affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_000818.2 NP_001107655.1

ENSEMBL proteins:

ENSP00000339343 ENSP00000285900

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant GRIA1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Glutamate Receptor 1 (AMPA subtype))
	Human Recombinant Proteins from Abnova (GRIA1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/9 Gene Ontology (GO) cellular component terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	IEA	--
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005886	plasma membrane	TAS	1311100
GO:0016021	integral to membrane	IEA	--

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Antibodies for GRIA1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of GRIA1
	Sigma-Aldrich Antibodies for GRIA1
	R&D Systems Antibodies for GRIA1 (GluR1)
	Antibodies from Abcam (Glutamate Receptor 1 (AMPA subtype)), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for GRIA1

Assays for GRIA1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P42261

ProtoNet protein and cluster: P42261

3 Blocks protein families:

IPB001320 Ionotropic glutamate receptor

IPB001508 NMDA receptor signature

IPB001828 Extracellular ligand-binding receptor

UniProtKB/Swiss-Prot: GRIA1_HUMAN, P42261

Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GRIA1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GRIA1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000827

Applied Biosystems Silencer® siRNAs for GRIA1

Sigma-Aldrich siRNA and siRNA Panels for GRIA1

Sigma-Aldrich shRNA for GRIA1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000827
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000827
untagged cDNA clones in CMV expression vector (see all 2): NM_000827

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000827

UniProtKB/Swiss-Prot: GRIA1_HUMAN, P42261

Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many

synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate

induces a conformation change, leading to the opening of the cation channel, and thereby converts

the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a

transient inactive state, characterized by the presence of bound agonist

Genatlas biochemistry entry for GRIA1:

glutamate receptor,subunit 1,ionotropic,AMPA (amino-3-hydroxy 5 methyl-isoxazole-propionic)

class,with flip and flop isoforms,mediating the fast component of excitatory post synaptic

currents in the central nervous system,interacting with and signaling through the protein-kinase

LYN

7 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Gria1):

behavior/neurological	growth/size	homeostasis/metabolism	nervous system	no phenotypic analysis
normal	touch/vibrissae

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0005216	ion channel activity	IEA	--
GO:0005234	extracellular-glutamate-gated ion channel activity	IEA	--
GO:0005515	protein binding	IEA	--
GO:0015277	kainate selective glutamate receptor activity	TAS	1311100

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for GRIA1 (Your Favorite Gene powered by Ingenuity) (see all 7 )

Calcium Signaling
Glutamate Receptor Signaling
CREB Signaling in Neurons
Amyotrophic Lateral Sclerosis Signaling
Neuropathic Pain Signaling In Dorsal Horn Neurons

GeneDecks GRIA1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for GRIA1

5/64 Interacting proteins for GRIA1 (P42261² ENSP00000285900³) via UniProtKB, MINT, and/or STRING (see all 64 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRKACA	P17612², ENSP00000309591³	MINT-18147 STRING (score=.977)
IL8RB	P25025², ENSP00000319635³	MINT-49811 STRING (score=.768)
CAMK2G	ENSP00000319060³	STRING (score=.998)
DLG1	ENSP00000345731³	STRING (score=.997)
CACNG2	ENSP00000300105³	STRING (score=.99)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0007165	signal transduction	TAS	1311100
GO:0007268	synaptic transmission	TAS	1311100

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Enzo Life Sciences drugs & compounds for GRIA1

Sigma-Aldrich Small Molecules for GRIA1:

Mixed Agonist/Antagonist Antagonist Blocker Allosteric Modulator Agonist Ligand

Compounds for GRIA1 available from Tocris Bioscience

Compound	Action	CAS number
(S)-AMPA	Selective AMPA agonist. Active isomer of (RS)-AMPA (Cat. No. 0169)	[83643-88-3]
CP 465022 hydrochloride	Selective, non-competitive AMPA antagonist	[199655-36-2]
A 769662	Potent AMPK activator	[844499-71-4]
GYKI 52466 hydrochloride	Selective non-competitive AMPA antagonist	[102771-26-6]
NBQX disodium salt	More water soluble form of NBQX (Cat. No. 0373)	[118876-58-7]

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10/12 Novoseek chemical compound relationships for GRIA1 gene (see all 12 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium	41.93	22	9106453 (3), 9191113 (2), 11943807 (2), 1372254 (1) (see all 13)
guanylate	26.78	1	11567040 (1)
picrotoxin	15.05	2	9618545 (1), 14659507 (1)
asparagine	2.99	1	9680238 (1)
forskolin	0.43	2	15531103 (1)
oligonucleotide	0.00	2	8003684 (1), 7609609 (1)
nitric oxide	0.00	5	18728399 (2), 18031684 (1), 14659507 (1)
threonine	0.00	2	7681938 (1), 9680238 (1)
magnesium	0.00	1	9106453 (1)
zinc	0.00	5	9106453 (3), 8015375 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GRIA1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GRIA1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000827

Sigma-Aldrich siRNA and siRNA Panels for GRIA1

Sigma-Aldrich shRNA for GRIA1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000827 NM_001114183

REFSEQ mRNAs for GRIA1 gene (2 alternative transcripts):

NM_000827.3 NM_001114183.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000827 NM_001114183

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000827
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000827
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000827

Additional cDNA sequence:

AB209094.1 AK289565.1 AK294011.1 AK294773.1 AK295039.1 AK295184.1 AK295827.1 AK310189.1

AK315934.1 BC111734.1 M64752.1 M81886.1 X58633.1 Z70220.1

7 DOTS entries:

DT.91694020 DT.91694012 DT.100745104 DT.216973 DT.120883509 DT.91694015 DT.120883502

24/90 AceView cDNA sequences (see all 90 ):

AL120214 AI160145 AI371990 AL707273 AW236612 CA438561 T31307 F09838

BE222984 CB054445 F12208 F07524 Z39984 F03756 AL538420 BE551874

AW450563 AV718331 Z45881 N47974 F11057 T33928 AL567302 R87613

highest scoring ESTs for GRIA1:

M64752 M81886 F06917 F07524 F12177 X58633 AL538420 AW894126 AW897598 BF090061

Unigene Cluster for GRIA1:

Glutamate receptor, ionotropic, AMPA 1

Hs.519693 [show with all ESTs]

Unigene Representative Sequence: NM_000827

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for GRIA1

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18a	·	18b	·	18c
SP1:																																	-
SP2:									-																										-
SP3:									-																								-

About this scheme

ECgene alternative splicing isoforms for GRIA1

2 Ensembl transcripts including schematic representations:

ENST00000340592 ENST00000285900

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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GRIA1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GRIA1

¹ / ² / ³

7 probe-sets matching GRIA1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36855_r_at²^{, 3}	U95-A	1	1.00	1.00	0.47	1.34	M81886	1.00	0.90	0.95	1
36854_s_at²^{, 3}	U95-A	2	1.00	0.97	0.94	1.06	M81886	1.00	0.90	0.95	1
36853_at²^{, 3}	U95-A	1	0.94	1.00	0.81	1.08	M64752	1.00	0.90	0.95	1
211520_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M64752	1.00	0.90	0.95	1
209793_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL567302	0.40	1.00	0.76	1
211520_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209793_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks GRIA1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGCGGATAAA

SOURCE GeneReport for Unigene cluster: Hs.519693
Expression variation in blood from EXPOLDB for GRIA1
UniProtKB/Swiss-Prot: GRIA1_HUMAN, P42261
Tissue specificity: Widely expressed in brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for GRIA1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GRIA1¹	--	glutamate receptor, ionotropic, AMPA 1	94.08(n) 99.67(a)	489168 XM_848305.1 XP_853398.1
chimpanzee (Pan troglodytes)	GRIA1¹	--	glutamate receptor, ionotropic, AMPA 1	98.31(n) 99.01(a)	471714 XM_527092.2 XP_527092.2
mouse (Mus musculus)	Gria1^{1, 5}	11 (31.00 cM)⁵	glutamate receptor, ionotropic, AMPA1 (alpha 1)^{1, 5}	90.25(n)¹ 98.68(a)¹	14799¹ NM_008165.2¹ NP_032191.2¹ AI853806⁵ AK013661⁵ (see all 17)
chicken (Gallus gallus)	GRIA1¹	--	glutamate receptor, ionotropic, AMPA 1	82.71(n) 93.02(a)	414893 NM_001001774.1 NP_001001774.1
zebrafish (Danio rerio)	AF525742.1²	--	--	77.18(n)	AF525742.1

About this table Species with no ortholog for GRIA1

ENSEMBL Gene Tree for GRIA1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for GRIA1 gene

GRIA2² GRIA4² GRIA3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1944 NCBI SNPs in GRIA1 are shown (see all 1944 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 773)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs548294^1,2	A,C,F,H,O	152848630(-)	`taATAG/ACAGCA`	1	--	ng5¹		17	NS EU EA WA NA	1158
	rs3792766^1,2	C,F,H	152849817(+)	`TTAGGA/GGAGAG`	1	--	ng5¹ trp³		8	EU EA WA	796
	rs13166438^1,2	C,H	153065603(+)	`CTTTGG/TCTTAT`	2	A/S	mis¹ ese³		4	EU EA WA	420
	rs2926834^1,2	F,H	153173172(-)	`ATCCGC/TTCATG`	2	--	ut3¹		4	EU EA WA	420
	rs11951398^1,2	F,H	153172408(+)	`ATATAC/TGTATG`	2	--	ut3¹		4	EU EA WA	420
	rs13166146^1,2	C,H	153065456(+)	`GAGCAG/AATGTG`	2	N/D	mis¹ ese³		4	EU EA WA	408
--	rs13186047^1,2	H	153065466(+)	`GGCTGT/GGGCTC`	2	G/V	mis¹ ese³		4	EU EA WA	406
	rs13186534^1,2	H	153065759(+)	`GGATAT/CTCAAC`	2	L/F	mis¹		4	EU EA WA	420
--	rs13186241^1,2	H	153065641(+)	`TACATT/GGGAGT`	2	M/I	mis¹		4	EU EA WA	418
	rs13166161^1,2	H	153065558(+)	`AAAAAC/ACACAG`	2	T/P	mis¹ ese³		4	EU EA WA	418

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HapMap Linkage Disequilibrium images for GRIA1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 138248

10/11 Novoseek disease relationships for GRIA1 gene (see all 11 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
schizophrenia	26.88	12	17942280 (3), 16526023 (3), 7609609 (2), 9099808 (1) (see all 5)
alzheimers disease	25.89	10	10588576 (3), 7969894 (2), 7542540 (2), 9466422 (1) (see all 5)
bipolar disorder	24.70	2	17942280 (1), 18484081 (1)
drug withdrawal	21.30	2	9832144 (1), 16616767 (1)
epilepsy	20.60	4	9455976 (2), 8985700 (2)
neurofibrillary tangles	19.65	1	7542540 (1)
brain diseases	18.30	2	7969894 (1), 7542540 (1)
amyotrophic lateral sclerosis	18.10	1	8981413 (1)
inflammation	4.75	1	19116032 (1)
necrosis	0.00	5	10868778 (2), 12460558 (2), 9367294 (1)

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Human Genome Epidemiology Navigator: GRIA1 (7 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/236 PubMed articles for GRIA1 gene (see all 236 ):

Molecular cloning and chromosomal localization of one of the human glutamate receptor genes. (PubMed id 1652753)^{2, 3, 4} Puckett C.... Hood L.E. (1991)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The human glutamate receptor cDNA GluR1: cloning, sequencing, expression and localization to chromosome 5. (PubMed id 1320959)^{3, 4} Potier M.-C.... Carter N.P. (1992)
Chromosomal localization of human glutamate receptor genes. (PubMed id 1319477)^{2, 3} McNamara J.O....Heinemann S.F. (1992)
Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors. (PubMed id 1311100)^{3, 4} Sun W.... Montal M. (1992)
Glutamate AMPA receptor subunit 1 gene (GRIA1) and DSM-IV-TR schizophrenia: a pilot case-control association study in an Italian sample. (PubMed id 16526023)^{1, 3} Magri C....Barlati S. (2006)
Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway. (PubMed id 11567040)^{1, 3} Sans N....Wenthold R.J. (2001)
Identification of the Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate-type glutamate receptor. (PubMed id 9407043)^{1, 3} Barria A....Soderling T. (1997)
Polymorphisms in the GRIA1 gene region in psychotic bipolar disorder. (PubMed id 18484081)^{1, 3} Kerner B....Freimer N.B. (2008)
A novel anterograde trafficking signal present in the N-terminal extracellular domain of ionotropic glutamate receptors. (PubMed id 12368290)^{1, 3} Xia H....Malenka R.C. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2890	HGNC: 4571	AceView: GRIA1	Ensembl:ENSG00000155511	euGenes: HUgn2890
ECgene: GRIA1	H-InvDB: GRIA1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for GRIA1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GRIA1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GRIA1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GRIA1		Antibodies for GRIA1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GRIA1		Small molecules for GRIA1
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GRIA1)
	Search for Antibodies
	Chimera RNAi (GRIA1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Glutamate Receptor 1 (AMPA subtype))
	Antibodies (Glutamate Receptor 1 (AMPA subtype))

Search OriGene for GRIA1

Tocris compounds for GRIA1

	Drugs for GRIA1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GRIA1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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GRIA1 Gene at Home site.
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GRIA1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for GRIA1

Summaries
for GRIA1

Genomic Location
for GRIA1

Proteins
for GRIA1

Protein Domains/
Families
for GRIA1

Gene Function
for GRIA1

Pathways & Interactions
for GRIA1

Drugs & Compounds
for GRIA1

Transcripts
for GRIA1

Expression
for GRIA1

Orthologs
for GRIA1

Paralogs
for GRIA1

SNPs/Variants
for GRIA1

Disorders & Mutations
for GRIA1

Medical News
for GRIA1

Publications
for GRIA1

Search for GRIA1

Genome Databases showing GRIA1

Other Databases showing GRIA1

Specialized Databases showing GRIA1

Licensable Technologies
for GRIA1

Services
for GRIA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GRIA1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor GRIA1

Summariesfor GRIA1

Genomic Locationfor GRIA1

Proteinsfor GRIA1

Protein Domains/Familiesfor GRIA1

Gene Functionfor GRIA1

Pathways & Interactionsfor GRIA1

Drugs & Compoundsfor GRIA1

Transcriptsfor GRIA1

Expression for GRIA1

Orthologsfor GRIA1

Paralogsfor GRIA1

SNPs/Variantsfor GRIA1

Disorders & Mutationsfor GRIA1

Medical Newsfor GRIA1

Publicationsfor GRIA1

Search for GRIA1

Genome Databases showing GRIA1

Other Databases showing GRIA1

Specialized Databases showing GRIA1

Licensable Technologiesfor GRIA1

Servicesfor GRIA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GRIA1

Summaries
for GRIA1

Genomic Location
for GRIA1

Proteins
for GRIA1

Protein Domains/
Families
for GRIA1

Gene Function
for GRIA1

Pathways & Interactions
for GRIA1

Drugs & Compounds
for GRIA1

Transcripts
for GRIA1

Expression
for GRIA1

Orthologs
for GRIA1

Paralogs
for GRIA1

SNPs/Variants
for GRIA1

Disorders & Mutations
for GRIA1

Medical News
for GRIA1

Publications
for GRIA1

Licensable Technologies
for GRIA1

Services
for GRIA1