Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GRIA1 Gene

Aliases for GRIA1 Gene

  • Glutamate Ionotropic Receptor AMPA Type Subunit 1 2 3
  • Glutamate Receptor, Ionotropic, AMPA 1 2 3 5
  • AMPA-Selective Glutamate Receptor 1 3 4
  • GluR-K1 3 4
  • GluR-1 3 4
  • GluR-A 3 4
  • GLUR1 3 4
  • GLUH1 3 4
  • GluA1 3 4
  • Glutamate Receptor Ionotropic, AMPA 1 4
  • AMPA 1 3
  • GLURA 3
  • HBGR1 3

External Ids for GRIA1 Gene

Previous HGNC Symbols for GRIA1 Gene

  • GLUR1

Previous GeneCards Identifiers for GRIA1 Gene

  • GC05P152945
  • GC05P152898
  • GC05P152850
  • GC05P148010

Summaries for GRIA1 Gene

Entrez Gene Summary for GRIA1 Gene

  • Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRIA1 Gene

GRIA1 (Glutamate Ionotropic Receptor AMPA Type Subunit 1) is a Protein Coding gene. Diseases associated with GRIA1 include Status Epilepticus and Fragile X Syndrome. Among its related pathways are Trafficking of AMPA receptors and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include PDZ domain binding and extracellular-glutamate-gated ion channel activity. An important paralog of this gene is GRID1.

UniProtKB/Swiss-Prot for GRIA1 Gene

  • Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Tocris Summary for GRIA1 Gene

  • AMPA receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and kainate receptors. AMPA receptors mediate fast excitatory synaptic transmission and play a role in hippocampal synaptic long-term potentiation and depression.

Gene Wiki entry for GRIA1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIA1 Gene

Genomics for GRIA1 Gene

Regulatory Elements for GRIA1 Gene

Enhancers for GRIA1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GRIA1 on UCSC Golden Path with GeneCards custom track

Promoters for GRIA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GRIA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GRIA1 Gene

Chromosome:
5
Start:
153,489,615 bp from pter
End:
153,813,873 bp from pter
Size:
324,259 bases
Orientation:
Plus strand

Genomic View for GRIA1 Gene

Genes around GRIA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIA1 Gene

Proteins for GRIA1 Gene

  • Protein details for GRIA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42261-GRIA1_HUMAN
    Recommended name:
    Glutamate receptor 1
    Protein Accession:
    P42261
    Secondary Accessions:
    • B7Z2S0
    • B7Z2W8
    • B7Z3F6
    • B7Z9G9
    • D3DQI4
    • E7ESV8
    • Q2NKM6

    Protein attributes for GRIA1 Gene

    Size:
    906 amino acids
    Molecular mass:
    101506 Da
    Quaternary structure:
    • Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with DLG1 via its C-terminus. Found in a complex with GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with HIP1, RASGRF2, SYNDIG1 and LRFN1. Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes. Interacts (via PDZ-binding motif) with SHANK3 (via PDZ domain).
    Miscellaneous:
    • The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.

    Alternative splice isoforms for GRIA1 Gene

neXtProt entry for GRIA1 Gene

Proteomics data for GRIA1 Gene at MOPED

Post-translational modifications for GRIA1 Gene

  • Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
  • Glycosylation at Asn 63, Asn 249, Asn 257, Asn 363, Asn 401, and Asn 406
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GRIA1 Gene

Domains & Families for GRIA1 Gene

Gene Families for GRIA1 Gene

Graphical View of Domain Structure for InterPro Entry

P42261

UniProtKB/Swiss-Prot:

GRIA1_HUMAN :
  • The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily.
Domain:
  • The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily.
genes like me logo Genes that share domains with GRIA1: view

Function for GRIA1 Gene

Molecular function for GRIA1 Gene

GENATLAS Biochemistry:
glutamate receptor,subunit 1,ionotropic,AMPA (amino-3-hydroxy 5 methyl-isoxazole-propionic) class,with flip and flop isoforms,mediating the fast component of excitatory post synaptic currents in the central nervous system,interacting with and signaling through the protein-kinase LYN
UniProtKB/Swiss-Prot Function:
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
genes like me logo Genes that share phenotypes with GRIA1: view

Animal Models for GRIA1 Gene

MGI Knock Outs for GRIA1:

Animal Model Products

  • Taconic Biosciences Mouse Models for GRIA1

miRNA for GRIA1 Gene

miRTarBase miRNAs that target GRIA1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRIA1 Gene

Localization for GRIA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIA1 Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell projection, dendritic spine. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRIA1 Gene COMPARTMENTS Subcellular localization image for GRIA1 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
plasma membrane 5
golgi apparatus 4
cytoskeleton 2
extracellular 2
nucleus 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GRIA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0008021 synaptic vesicle IEA --
GO:0012507 ER to Golgi transport vesicle membrane TAS --
GO:0014069 postsynaptic density IEA,ISS --
GO:0030425 dendrite IEA,ISS --
genes like me logo Genes that share ontologies with GRIA1: view

Pathways & Interactions for GRIA1 Gene

genes like me logo Genes that share pathways with GRIA1: view

Gene Ontology (GO) - Biological Process for GRIA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with GRIA1: view

No data available for SIGNOR curated interactions for GRIA1 Gene

Drugs & Compounds for GRIA1 Gene

(63) Drugs for GRIA1 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Desflurane Approved Pharma antagonist, Target 128
Enflurane Approved Pharma Target, antagonist 2
Isoflurane Approved Pharma agonist, Target, antagonist 153
Sevoflurane Approved Pharma antagonist, Target 445
Cyclothiazide Approved Pharma Positive, Allosteric regulator, inhibitor 0

(11) Additional Compounds for GRIA1 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(R)-AMPA
83654-13-1
(RS)-AMPA
74341-63-2
(RS)-AMPA hydrobromide
171259-81-7
(S)-AMPA
83643-88-3
L-Quisqualic acid
52809-07-1

(5) Tocris Compounds for GRIA1 Gene

Compound Action Cas Number
(R)-AMPA Inactive isomer of (RS)-AMPA (Cat. No. 0169) 83654-13-1
(RS)-AMPA Selective AMPA agonist 74341-63-2
(RS)-AMPA hydrobromide Selective AMPA agonist. More water soluble form of (RS)-AMPA (Cat. No. 0169) 171259-81-7
(S)-AMPA Selective AMPA agonist. Active isomer of (RS)-AMPA (Cat. No. 0169) 83643-88-3
L-Quisqualic acid AMPA/group I mGlu agonist 52809-07-1

(8) ApexBio Compounds for GRIA1 Gene

Compound Action Cas Number
ADX-47273 851881-60-2
IEM 1754 dihydrobroMide 162831-31-4
Ifenprodil Tartrate NMDA receptor antagonist 23210-58-4
Latrepirdine Brain cell death inhibitor 97657-92-6
NMDA (N-Methyl-D-aspartic acid) NMDA receptor agonist 6384-92-5
VU 0361737 MGlu4 receptor allosteric modulator 1161205-04-4
VU 0364439 Positive allosteric mGluR-4 modulator 1246086-78-1
VU 0364770 61350-00-3
genes like me logo Genes that share compounds with GRIA1: view

Transcripts for GRIA1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for GRIA1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1: -
SP2: - -
SP3: - -

Relevant External Links for GRIA1 Gene

GeneLoc Exon Structure for
GRIA1
ECgene alternative splicing isoforms for
GRIA1

Expression for GRIA1 Gene

mRNA expression in normal human tissues for GRIA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIA1 Gene

This gene is overexpressed in Brain - Hippocampus (x7.0), Brain - Cerebellum (x5.6), Brain - Anterior cingulate cortex (BA24) (x5.1), and Brain - Amygdala (x4.8).

Protein differential expression in normal tissues from HIPED for GRIA1 Gene

This gene is overexpressed in Frontal cortex (28.3), Brain (27.3), and Fetal Brain (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRIA1 Gene



SOURCE GeneReport for Unigene cluster for GRIA1 Gene Hs.519693

mRNA Expression by UniProt/SwissProt for GRIA1 Gene

P42261-GRIA1_HUMAN
Tissue specificity: Widely expressed in brain.
genes like me logo Genes that share expression patterns with GRIA1: view

Protein tissue co-expression partners for GRIA1 Gene

- Elite partner

Primer Products

Orthologs for GRIA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GRIA1 35
  • 93.41 (n)
  • 99.56 (a)
GRIA1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRIA1 35
  • 94.22 (n)
  • 99.78 (a)
GRIA1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gria1 35
  • 90.03 (n)
  • 98.12 (a)
Gria1 16
Gria1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GRIA1 35
  • 98.38 (n)
  • 99.12 (a)
GRIA1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gria1 35
  • 88.78 (n)
  • 97.24 (a)
oppossum
(Monodelphis domestica)
Mammalia GRIA1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRIA1 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRIA1 35
  • 84.04 (n)
  • 94.01 (a)
GLUR1/A 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRIA1 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gria1 35
  • 77.12 (n)
  • 88.14 (a)
zebrafish
(Danio rerio)
Actinopterygii gria1a 35
  • 72.71 (n)
  • 76.15 (a)
gria1a 36
  • 74 (a)
OneToMany
gria1b 36
  • 72 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12064 35
fruit fly
(Drosophila melanogaster)
Insecta CG11155 37
  • 50 (a)
CG15627 37
  • 33 (a)
CG4226 37
  • 28 (a)
CG9935 37
  • 40 (a)
Glu-RI 37
  • 40 (a)
Glu-RIB 37
  • 66 (a)
Glu-RIIA 37
  • 29 (a)
Glu-RIIB 37
  • 27 (a)
Kai-RIA 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea glr-1 37
  • 46 (a)
glr-4 37
  • 31 (a)
Species with no ortholog for GRIA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRIA1 Gene

ENSEMBL:
Gene Tree for GRIA1 (if available)
TreeFam:
Gene Tree for GRIA1 (if available)

Paralogs for GRIA1 Gene

Paralogs for GRIA1 Gene

(9) SIMAP similar genes for GRIA1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GRIA1: view

Variants for GRIA1 Gene

Sequence variations from dbSNP and Humsavar for GRIA1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs13166146 - 153,705,703(+) GAGCA(A/G)ATGTG nc-transcript-variant, reference, missense
rs13166161 - 153,705,805(+) AAAAA(A/C)CACAG nc-transcript-variant, reference, missense
rs13166438 - 153,705,850(+) CTTTG(G/T)CTTAT nc-transcript-variant, reference, missense
rs13186241 - 153,705,888(+) TACAT(G/T)GGAGT nc-transcript-variant, reference, missense
rs13186534 - 153,706,006(+) GGATA(C/T)TCAAC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GRIA1 Gene

Variant ID Type Subtype PubMed ID
esv2657105 CNV Deletion 23128226
esv2674452 CNV Deletion 23128226
esv271709 CNV Insertion 20981092
nsv507300 CNV Insertion 20534489
esv2730932 CNV Deletion 23290073
esv2730933 CNV Deletion 23290073
esv5069 CNV Deletion 18987735
nsv883054 CNV Loss 21882294
dgv1864e1 CNV Complex 17122850
esv2677751 CNV Deletion 23128226
nsv883055 CNV Loss 21882294

Variation tolerance for GRIA1 Gene

Residual Variation Intolerance Score: 2.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.96; 74.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRIA1 Gene

Human Gene Mutation Database (HGMD)
GRIA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIA1 Gene

Disorders for GRIA1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for GRIA1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
status epilepticus
  • gcse
fragile x syndrome
  • fragile x mental retardation syndrome
cerebritis
limbic encephalitis
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search GRIA1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GRIA1

Genetic Association Database (GAD)
GRIA1
Human Genome Epidemiology (HuGE) Navigator
GRIA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRIA1
genes like me logo Genes that share disorders with GRIA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRIA1 Gene

Publications for GRIA1 Gene

  1. Molecular cloning and chromosomal localization of one of the human glutamate receptor genes. (PMID: 1652753) Puckett C. … Hood L.E. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 67
  2. Anesthetics produce subunit-selective actions on glutamate receptors. (PMID: 8786535) Dildy-Mayfield J.E. … Harris R.A. (J. Pharmacol. Exp. Ther. 1996) 23 25 26
  3. Polymorphisms in the GRIA1 gene region in psychotic bipolar disorder. (PMID: 18484081) Kerner B. … Freimer N.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 23
  4. AMPA receptors promote perivascular glioma invasion via beta1 integrin-dependent adhesion to the extracellular matrix. (PMID: 18957620) Piao Y. … de Groot J. (Neuro-oncology 2009) 3 23
  5. AKAP79 selectively enhances protein kinase C regulation of GluR1 at a Ca2+-calmodulin-dependent protein kinase II/protein kinase C site. (PMID: 18305116) Tavalin S.J. (J. Biol. Chem. 2008) 3 23

Products for GRIA1 Gene

Sources for GRIA1 Gene

Content