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Aliases for GRIA1 Gene

Aliases for GRIA1 Gene

  • Glutamate Receptor, Ionotropic, AMPA 1 2 3
  • GLUR1 3 4 6
  • AMPA-Selective Glutamate Receptor 1 3 4
  • GluR-K1 3 4
  • GluR-1 3 4
  • GluR-A 3 4
  • GLUH1 3 4
  • GluA1 3 4
  • Glutamate Receptor Ionotropic, AMPA 1 4
  • Glutamate Receptor 1 3
  • AMPA 1 3
  • GLURA 3
  • HBGR1 3

External Ids for GRIA1 Gene

Previous HGNC Symbols for GRIA1 Gene

  • GLUR1

Previous GeneCards Identifiers for GRIA1 Gene

  • GC05P152945
  • GC05P152898
  • GC05P152850
  • GC05P148010

Summaries for GRIA1 Gene

Entrez Gene Summary for GRIA1 Gene

  • Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRIA1 Gene

GRIA1 (Glutamate Receptor, Ionotropic, AMPA 1) is a Protein Coding gene. Diseases associated with GRIA1 include limbic encephalitis. Among its related pathways are CREB Pathway and CREB Pathway. GO annotations related to this gene include PDZ domain binding and glutamate receptor activity. An important paralog of this gene is GRID2.

UniProtKB/Swiss-Prot for GRIA1 Gene

  • Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Tocris Summary for GRIA1 Gene

  • AMPA receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and kainate receptors. AMPA receptors mediate fast excitatory synaptic transmission in the CNS and play a key role in hippocampal synaptic long-term potentiation (LTP) and depression (LTD). AMPA receptors consist of GluR1-4 subunits which assemble as homomers or heteromers to form functional AMPA receptors. The subunit composition determines the physiological properties of AMPA receptors: those containing the GluR2 subunit show low permeability to Ca2+ whereas those lacking this subunit show high Ca2+ permeability.

Gene Wiki entry for GRIA1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIA1 Gene

Genomics for GRIA1 Gene

Regulatory Elements for GRIA1 Gene

Genomic Location for GRIA1 Gene

Start:
153,489,615 bp from pter
End:
153,813,869 bp from pter
Size:
324,255 bases
Orientation:
Plus strand

Genomic View for GRIA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRIA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIA1 Gene

Proteins for GRIA1 Gene

  • Protein details for GRIA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42261-GRIA1_HUMAN
    Recommended name:
    Glutamate receptor 1
    Protein Accession:
    P42261
    Secondary Accessions:
    • B7Z2S0
    • B7Z2W8
    • B7Z3F6
    • B7Z9G9
    • D3DQI4
    • E7ESV8
    • Q2NKM6

    Protein attributes for GRIA1 Gene

    Size:
    906 amino acids
    Molecular mass:
    101506 Da
    Quaternary structure:
    • Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with DLG1 via its C-terminus. Found in a complex with GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with HIP1, RASGRF2, SYNDIG1 and LRFN1. Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes. Interacts (via PDZ-binding motif) with SHANK3 (via PDZ domain).
    Miscellaneous:
    • The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate

    Alternative splice isoforms for GRIA1 Gene

neXtProt entry for GRIA1 Gene

Proteomics data for GRIA1 Gene at MOPED

Post-translational modifications for GRIA1 Gene

  • Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
  • Glycosylation at Asn63, Asn249, Asn257, Asn363, Asn401, and Asn406
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GRIA1 (GluR1)

No data available for DME Specific Peptides for GRIA1 Gene

Domains for GRIA1 Gene

Gene Families for GRIA1 Gene

HGNC:
  • GR :Glutamate receptors
  • GRI :Ligand-gated ion channels / Glutamate receptors, ionotropic
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P42261

UniProtKB/Swiss-Prot:

GRIA1_HUMAN :
  • P42261
Domain:
  • The M4 transmembrane segment mediates tetramerization and is required for cell surface expression
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily.
genes like me logo Genes that share domains with GRIA1: view

Function for GRIA1 Gene

Molecular function for GRIA1 Gene

GENATLAS Biochemistry: glutamate receptor,subunit 1,ionotropic,AMPA (amino-3-hydroxy 5 methyl-isoxazole-propionic) class,with flip and flop isoforms,mediating the fast component of excitatory post synaptic currents in the central nervous system,interacting with and signaling through the protein-kinase LYN
UniProtKB/Swiss-Prot Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Gene Ontology (GO) - Molecular Function for GRIA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004970 ionotropic glutamate receptor activity --
GO:0004971 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity IDA 20805473
GO:0005234 extracellular-glutamate-gated ion channel activity IBA --
GO:0005515 protein binding IPI 20805473
GO:0008066 glutamate receptor activity TAS 1320959
genes like me logo Genes that share ontologies with GRIA1: view
genes like me logo Genes that share phenotypes with GRIA1: view

Animal Models for GRIA1 Gene

MGI Knock Outs for GRIA1:

Animal Model Products

CRISPR Products

miRNA for GRIA1 Gene

miRTarBase miRNAs that target GRIA1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRIA1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GRIA1 Gene

Localization for GRIA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIA1 Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell projection, dendritic spine. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRIA1 Gene COMPARTMENTS Subcellular localization image for GRIA1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
cytoskeleton 4
extracellular 2
nucleus 2
endosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GRIA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0008021 synaptic vesicle IEA --
GO:0008328 ionotropic glutamate receptor complex --
genes like me logo Genes that share ontologies with GRIA1: view

Pathways for GRIA1 Gene

genes like me logo Genes that share pathways with GRIA1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GRIA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 1311100
GO:0007268 synaptic transmission TAS --
GO:0007616 long-term memory IEA --
GO:0031623 receptor internalization IEA --
GO:0034220 ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with GRIA1: view

Compounds for GRIA1 Gene

(5) Tocris Compounds for GRIA1 Gene

Compound Action Cas Number
CNQX disodium salt Potent AMPA/kainate antagonist. More water soluble form of CNQX (Cat. No. 0190) [479347-85-8]
DNQX Selective non-NMDA antagonist [2379-57-9]
DNQX disodium salt Selective non-NMDA antagonist. Water-soluble salt of DNQX (Cat. No. 0189) [1312992-24-7]
NBQX Potent AMPA antagonist. More selective than CNQX (Cat. No. 0190) [118876-58-7]
NBQX disodium salt Potent AMPA antagonist. More water soluble form of NBQX (Cat. No. 0373) [479347-86-9]

(7) Drugbank Compounds for GRIA1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Desflurane
  • Desflurano [INN-Spanish]
57041-67-5 target antagonist
Enflurane
  • Anesthetic 347
13838-16-9 target antagonist
Isoflurane
26675-46-7 target antagonist
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target
Methoxyflurane
  • Methoflurane
76-38-0 target antagonist

(21) IUPHAR Ligand for GRIA1 Gene

Ligand Type Action Affinity Pubmed IDs
S18986 Allosteric regulator Positive
LY392098 Allosteric regulator Positive
CX546 Allosteric regulator Positive
CX516 Allosteric regulator Positive
argiotoxin Channel blocker None
joro toxin Channel blocker None
piracetam Allosteric regulator Positive
[3H]CNQX None None
ATPO Antagonist Antagonist
GYKI53655 Antagonist Antagonist
NBQX Antagonist Antagonist
GYKI53784 Antagonist Antagonist
AMPA Agonist Full agonist
[3H]AMPA None None
aniracetam Allosteric regulator Positive
LY293558 Antagonist Antagonist
(S)-5-fluorowillardiine Agonist Full agonist
cyclothiazide Allosteric regulator Positive
LY404187 Allosteric regulator Positive
IDRA-21 Allosteric regulator Positive
LY503430 Allosteric regulator Positive

(27) Novoseek inferred chemical compound relationships for GRIA1 Gene

Compound -log(P) Hits PubMed IDs
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid 87.4 10
glutamate 85.1 97
kainate 81 31
nmda 76.2 30
cyclothiazide 63.2 2
genes like me logo Genes that share compounds with GRIA1: view

Transcripts for GRIA1 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRIA1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for GRIA1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIA1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1: -
SP2: - -
SP3: - -

Relevant External Links for GRIA1 Gene

GeneLoc Exon Structure for
GRIA1
ECgene alternative splicing isoforms for
GRIA1

Expression for GRIA1 Gene

mRNA expression in normal human tissues for GRIA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIA1 Gene

This gene is overexpressed in Brain - Hippocampus (7.0), Brain - Cerebellum (5.6), Brain - Anterior cingulate cortex (BA24) (5.1), and Brain - Amygdala (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GRIA1 Gene

SOURCE GeneReport for Unigene cluster for GRIA1 Gene Hs.519693

mRNA Expression by UniProt/SwissProt for GRIA1 Gene

P42261-GRIA1_HUMAN
Tissue specificity: Widely expressed in brain
genes like me logo Genes that share expressions with GRIA1: view

In Situ Assay Products

Orthologs for GRIA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRIA1 35
  • 98.38 (n)
  • 99.12 (a)
GRIA1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GRIA1 35
  • 93.41 (n)
  • 99.56 (a)
GRIA1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRIA1 35
  • 94.22 (n)
  • 99.78 (a)
GRIA1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gria1 35
  • 90.03 (n)
  • 98.12 (a)
Gria1 16
Gria1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRIA1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRIA1 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gria1 35
  • 88.78 (n)
  • 97.24 (a)
chicken
(Gallus gallus)
Aves GLUR1/A 36
  • 91 (a)
OneToOne
GRIA1 35
  • 84.04 (n)
  • 94.01 (a)
lizard
(Anolis carolinensis)
Reptilia GRIA1 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gria1 35
  • 77.12 (n)
  • 88.14 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12064 35
zebrafish
(Danio rerio)
Actinopterygii gria1a 35
  • 72.71 (n)
  • 76.15 (a)
gria1a 36
  • 74 (a)
OneToMany
gria1b 36
  • 72 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4226 37
  • 28 (a)
CG15627 37
  • 33 (a)
Glu-RIIA 37
  • 29 (a)
Glu-RIB 37
  • 66 (a)
Glu-RI 37
  • 40 (a)
Glu-RIIB 37
  • 27 (a)
CG9935 37
  • 40 (a)
Kai-RIA 37
  • 34 (a)
CG11155 37
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea glr-1 37
  • 46 (a)
glr-4 37
  • 31 (a)
Species with no ortholog for GRIA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRIA1 Gene

ENSEMBL:
Gene Tree for GRIA1 (if available)
TreeFam:
Gene Tree for GRIA1 (if available)

Paralogs for GRIA1 Gene

Paralogs for GRIA1 Gene

Selected SIMAP similar genes for GRIA1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GRIA1: view

Variants for GRIA1 Gene

Sequence variations from dbSNP and Humsavar for GRIA1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs472792 -- 153,491,624(-) CAGGC(G/T)AGGAA intron-variant, upstream-variant-2KB
rs475583 -- 153,524,764(-) GCCAA(C/G)AAGGT intron-variant
rs478962 -- 153,527,327(-) cgatg(C/T)accta intron-variant
rs479767 -- 153,527,276(-) atttg(A/G)tttgc intron-variant
rs479946 -- 153,527,212(-) tagct(A/C)ttgga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRIA1 Gene

Variant ID Type Subtype PubMed ID
esv2657105 CNV Deletion 23128226
esv2674452 CNV Deletion 23128226
esv271709 CNV Insertion 20981092
nsv507300 CNV Insertion 20534489
esv2730932 CNV Deletion 23290073
esv2730933 CNV Deletion 23290073
esv5069 CNV Deletion 18987735
nsv883054 CNV Loss 21882294
dgv1864e1 CNV Complex 17122850
esv2677751 CNV Deletion 23128226
nsv883055 CNV Loss 21882294

Relevant External Links for GRIA1 Gene

HapMap Linkage Disequilibrium report
GRIA1
Human Gene Mutation Database (HGMD)
GRIA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIA1 Gene

Disorders for GRIA1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for GRIA1 Gene including...

Search for GRIA1 Gene in MalaCards »

(3) University of Copenhagen DISEASES for GRIA1 Gene

(12) Novoseek inferred disease relationships for GRIA1 Gene

Disease -log(P) Hits PubMed IDs
alzheimers disease 27.6 9
schizophrenia 24.4 10
bipolar disorder 21.9 2
epilepsy 21.4 4
drug withdrawal 19 2

Relevant External Links for GRIA1

Genetic Association Database (GAD)
GRIA1
Human Genome Epidemiology (HuGE) Navigator
GRIA1
genes like me logo Genes that share disorders with GRIA1: view

No data available for UniProtKB/Swiss-Prot for GRIA1 Gene

Publications for GRIA1 Gene

  1. Glutamate AMPA receptor subunit 1 gene (GRIA1) and DSM-IV-TR schizophrenia: a pilot case-control association study in an Italian sample. (PMID: 16526023) Magri C. … Barlati S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006) 3 23 48
  2. Molecular cloning and chromosomal localization of one of the human glutamate receptor genes. (PMID: 1652753) Puckett C. … Hood L.E. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4
  3. Polymorphisms in the GRIA1 gene region in psychotic bipolar disorder. (PMID: 18484081) Kerner B. … Freimer N.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 23 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors. (PMID: 1311100) Sun W. … Montal M. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4

Products for GRIA1 Gene

  • Addgene plasmids for GRIA1

Sources for GRIA1 Gene

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