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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GRIA1 Gene

protein-coding   GIFtS: 69
GCID: GC05P152850

glutamate receptor, ionotropic, AMPA 1


(Previous symbol: GLUR1)
 Explore 30 diseases affiliated with
GRIA1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GRIA1    

Aliases
for GRIA1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Glutamate Receptor, Ionotropic, AMPA 11 2     GluR-13
GLUR11 2 3 5     GluR-A3
GluA11 2 3     GluR-K13
GLURA1 2     Glutamate Receptor 12
GLUH12 3     GluR-13
AMPA-Selective Glutamate Receptor 12 3     GluR-A3
HBGR12     GluR-K13
AMPA 12     Glutamate Receptor Ionotropic, AMPA 13

External Ids:    HGNC: 45711   Entrez Gene: 28902   Ensembl: ENSG000001555117   OMIM: 1382485   UniProtKB: P422613   

Export aliases for GRIA1 gene to outside databases

Previous GC identifers: GC05P152945 GC05P153467 GC05P152898 GC05P148010


Summaries
for GRIA1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GRIA1:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated
in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple
subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The
classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene
belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GRIA1_HUMAN, P42261
Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the
central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading
to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor
then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In
the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of
current flux upon continued application of glutamate

summary for GRIA1:
AMPA receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and
kainate receptors. AMPA receptors mediate fast excitatory synaptic transmission in the CNS and play a key
role in hippocampal synaptic long-term potentiation (LTP) and depression (LTD). AMPA receptors consist of
GluR1-4 subunits which assemble as homomers or heteromers to form functional AMPA receptors. The subunit
composition determines the physiological properties of AMPA receptors: those containing the GluR2 subunit
show low permeability to Ca2+ whereas those lacking this subunit show high Ca2+ permeability.

Gene Wiki entry for GRIA1


Genomic Views
for GRIA1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_029289.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GRIA1 gene promoter:
         AML1a   FOXF2   NF-kappaB   MZF-1   FOXO4   FOXJ2 (long isoform)   NF-kappaB2   aMEF-2   FOXJ2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GRIA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GRIA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRIA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q33.2   HGNC cytogenetic band: 5q33

GRIA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRIA1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P152850:  view genomic region     (about GC identifiers)

Start:
 152,869,175 bp from pter      End:
 153,193,429 bp from pter
Size:
 324,255 bases      Orientation:
 plus strand

Proteins
for GRIA1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GRIA1_HUMAN, P42261 (See protein sequence)
Recommended Name: Glutamate receptor 1 precursor  
Size: 906 amino acids; 101506 Da
Subunit: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the
dimerization of dimers. Interacts with DLG1 via its C-terminus. Interacts with SYNDIG1 and GRIA2 (By similarity).
Interacts with LRFN1 (By similarity). Interacts with HIP1 and RASGRF2 (By similarity). Found in a complex with GRIA2,
GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity). Interacts with CACNG5
(By similarity). Interacts with CNIH2 and CACNG2
Subcellular location: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane
protein (By similarity). Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell
junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell projection, dendrite (By
similarity). Cell projection, dendritic spine (By similarity). Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes
cell surface expression (By similarity)
Miscellaneous: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their
selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate
Secondary accessions: B7Z2S0 B7Z3F6 D3DQI4 Q2NKM6
Alternative splicing: 4 isoforms:  P42261-1   P42261-2   P42261-3   P42261-4   

Explore the universe of human proteins at neXtProt for GRIA1: NX_P42261

Post-translational modifications:

  • Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and
    • decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but
    regulates stimulation-dependent endocytosis (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P42261

    • GRIA1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (7 alternative transcripts): 
    NP_000818.2  NP_001107655.1  NP_001244948.1  NP_001244949.1  NP_001244950.1  NP_001244951.1  NP_001244952.1  

    ENSEMBL proteins: 
     ENSP00000285900   ENSP00000427920   ENSP00000339343   ENSP00000427864   ENSP00000428994  
     ENSP00000444321   ENSP00000441507   ENSP00000415569   ENSP00000442108  
    Reactome Protein details: P42261
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: GRIA1
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    Novus Biologicals GRIA1 Protein
    Novus Biologicals GRIA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for GRIA1

    Gene Ontology (GO): 5/18 cellular component terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005886plasma membrane TAS--
    GO:0008328ionotropic glutamate receptor complex ----
    GO:0009986cell surface ISS--


    GRIA1 for ontologies           About GeneDecksing



    GRIA1 Antibody Products: 
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    Uscn ELISAs and CLIAs for GRIA1

    Protein Domains /
    Families
    for GRIA1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GRIA1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR019594 Glu_rcpt_Glu/Gly-bd
     IPR001320 Iontro_glu_rcpt
     IPR001828 ANF_lig-bd_rcpt
     IPR001508 NMDA_rcpt

    Graphical View of Domain Structure for InterPro Entry P42261

    ProtoNet protein and cluster: P42261

    3 Blocks protein families:
    IPB001320 Ionotropic glutamate receptor
    IPB001508 NMDA receptor signature
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GRIA1_HUMAN, P42261
    Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily


    Function
    for GRIA1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GRIA1_HUMAN, P42261
    Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the
    central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading
    to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor
    then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In
    the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of
    current flux upon continued application of glutamate

         Genatlas biochemistry entry for GRIA1:
    glutamate receptor,subunit 1,ionotropic,AMPA (amino-3-hydroxy 5 methyl-isoxazole-propionic) class,with flip and flop
    isoforms,mediating the fast component of excitatory post synaptic currents in the central nervous system,interacting
    with and signaling through the protein-kinase LYN

    miRNA
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    hsa-mir-192 (MIRT004156)

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    8/67 QIAGEN miScript miRNA Assays for microRNAs that regulate GRIA1 (see all 67):
    hsa-miR-576-3p hsa-miR-579 hsa-miR-300 hsa-miR-128 hsa-miR-3653 hsa-miR-578 hsa-miR-138-2* hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmid: GRIA1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GRIA1 (see all 7)
    OriGene shRNA RFP: GRIA1
    OriGene siRNA: GRIA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRIA1

    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004970ionotropic glutamate receptor activity ----
    GO:0004971alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity IDA--
    GO:0005234extracellular-glutamate-gated ion channel activity IEA--
    GO:0005515protein binding IPI--
    GO:0008066glutamate receptor activity TAS1320959


    GRIA1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for GRIA1: Gria1tm2Rlh Gria1tm3Rlh Gria1tm1Ksak Gria1tm1Rsp
         7 MGI mutant phenotypes (inferred from 10 alleles) (MGI details for Gria1):
     behavior/neurological  growth/size  homeostasis/metabolism  integument  nervous system 
     no phenotypic analysis  normal 

    GRIA1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GRIA1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
    		Trafficking of AMPA receptors1.00
    		Trafficking of GluR2-containing AMPA receptors0.53
    		Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity1.00
    2Transmission across Chemical Synapses
    		Transmission across Chemical Synapses1.00
    		Neuronal System0.67
    		Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    3Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    		Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling1.00
    		Neurophysiological process_Glutamate regulation of Dopamine D1A receptor signaling0.98
    4Pathogenesis of ALS
    		Pathogenesis of ALS1.00
    		Amyotrophic lateral sclerosis (ALS)0.30
    5CREB Pathway
    		CREB Pathway1.00
    		Intracellular Calcium Signaling0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for GRIA1
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Glutamic acid signaling
    Calcium channels

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GRIA1
        Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Pathogenesis of ALS
    CREB Pathway
    Intracellular Calcium Signaling
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    1 Cell Signaling Technology (CST) Pathway for GRIA1
        Neuroscience

    1 GeneGo (Thomson Reuters) Pathway for GRIA1
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    2 BioSystems Pathways for GRIA1 
        Hypothetical Network for Drug Addiction
    EPHB forward signaling

    5/9        Reactome Pathways for GRIA1 (see all 9)
        Unblocking of NMDA receptor, glutamate binding and activation
    Transmission across Chemical Synapses
    Activation of AMPA receptors
    Neuronal System
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell


    5         Kegg Pathways  (Kegg details for GRIA1):
        Neuroactive ligand-receptor interaction
    Long-term potentiation
    Glutamatergic synapse
    Long-term depression
    Amyotrophic lateral sclerosis (ALS)


    GRIA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRIA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/70 Interacting proteins for GRIA1 (P422612, 3 ENSP000002859004) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CXCR2P250252, 3, ENSP000003196354MINT-49811 I2D: score=2 STRING: ENSP00000319635
    PRKACAP176122, 3, ENSP000003095914MINT-18147 I2D: score=2 STRING: ENSP00000309591
    GRIA2P422623, ENSP000002644264I2D: score=8 STRING: ENSP00000264426
    SDCBPO005603, ENSP000002601304I2D: score=4 STRING: ENSP00000260130
    GRIA4P480583, ENSP000002824994I2D: score=3 STRING: ENSP00000282499
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS1311100
    GO:0007268synaptic transmission TAS--
    GO:0007616long-term memory IEA--
    GO:0031623receptor internalization IEA--


    GRIA1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GRIA1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GRIA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GRIA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (S)-AMPASelective AMPA agonist. Active isomer of (RS)-AMPA (Cat. No. 0169)[83643-88-3]
    GYKI 52466 dihydrochlorideSelective non-competitive AMPA antagonist[102771-26-6]
    A 769662Potent AMPK activator[844499-71-4]
    NBQX disodium saltPotent AMPA antagonist. More water soluble form of NBQX (Cat. No. 0373)[118876-58-7]
    GYKI 53655 hydrochlorideNon-competitive AMPA receptor antagonist[143692-48-2]

    7 DrugBank Compounds for GRIA1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--1279377 7679210 7838123 17139284 17016423
    DesfluraneDesflurano [INN-Spanish] (see all 2)57041-67-5targetantagonist17139284 17016423 8786535
    MethoxyfluraneMethoflurane (see all 11)76-38-0targetantagonist17139284 7702639 17016423
    Isoflurane-- 26675-46-7targetantagonist8786535 17207582
    SevofluraneSevofluran (see all 3)28523-86-6targetantagonist17139284 17016423
    EnfluraneAnesthetic 347 (see all 7)13838-16-9targetantagonist8786535
    PhenobarbitalFenobarbital (see all 7)50-06-6targetantagonist20051697

    10/27 Novoseek chemical compound relationships for GRIA1 gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid 87.4 12 10101246 (1), 19338055 (1), 19261706 (1), 16246117 (1) (see all 10)
    glutamate 85.1 112 9832144 (3), 9120436 (2), 12763242 (2), 8873866 (2) (see all 90)
    kainate 81 39 8786535 (3), 8133291 (2), 9120436 (2), 9729352 (2) (see all 24)
    nmda 76.2 38 18045915 (3), 15519688 (3), 9674563 (2), 9618545 (2) (see all 23)
    cyclothiazide 63.2 3 15009673 (1), 7511109 (1)
    calcium 40.3 22 9106453 (3), 9191113 (2), 11943807 (2), 1372254 (1) (see all 13)
    k252a 34.4 5 17337442 (1), 15519688 (1)
    guanylate 25.1 1 11567040 (1)
    gaba 21.1 3 9618545 (1), 10235640 (1)
    picrotoxin 13.6 2 9618545 (1), 14659507 (1)

    Search CenterWatch for drugs/clinical trials and news about GRIA1 

    Transcripts
    for GRIA1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GRIA1 gene (7 alternative transcripts): 
    NM_000827.3  NM_001114183.1  NM_001258019.1  NM_001258020.1  NM_001258021.1  NM_001258022.1  NM_001258023.1  

    Unigene Clusters for GRIA1:

    Glutamate receptor, ionotropic, AMPA 1
    Hs.519693  [show with all ESTs], Hs.737709
    Unigene Representative Sequences: NM_001258020, Z70220
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481559(uc010jia.1) ENST00000520353 ENST00000518862 ENST00000285900(uc003lva.4 uc003luy.4 uc003luz.4 uc011dcv.2 uc011dcw.2)
    ENST00000474198 ENST00000518142 ENST00000340592 ENST00000517469 ENST00000521843
    ENST00000518783(uc011dcx.2 uc011dcy.2 uc011dcz.2) ENST00000492291
    ENST00000520966 ENST00000544403 ENST00000537037 ENST00000448073 ENST00000544794


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    8/67 QIAGEN miScript miRNA Assays for microRNAs that regulate GRIA1 (see all 67):
    hsa-miR-576-3p hsa-miR-579 hsa-miR-300 hsa-miR-128 hsa-miR-3653 hsa-miR-578 hsa-miR-138-2* hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmid: GRIA1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GRIA1 (see all 7)
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRIA1
    Clone
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    Additional cDNA sequence: Z70220.1 

    7 DOTS entries:

    DT.91694020  DT.91694012  DT.100745104  DT.120883509  DT.216973  DT.91694015  DT.120883502 

    24/90 AceView cDNA sequences (see all 90):

    AL120214 AI371990 AI160145 T31307 CA438561 F12208 CB054445 AW450563 
    F07524 AW236612 AL538420 F03756 AL707273 Z39984 BE222984 AV718331 
    F09838 BE551874 CB153668 R53133 BX489273 NM_000827 AL707593 AI866651 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GRIA1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c
    SP1:                                                                                                  -                                 
    SP2:                          -                                                                             -                           
    SP3:                          -                                                                       -                                 


    ECgene alternative splicing isoforms for GRIA1

    Expression
    for GRIA1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GRIA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCGGATAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GRIA1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneMandibular ProcessBone
    BoneMaxillary ProcessBone
    BrainHypothalamusBrain
    BrainMedulla OblongataBrain
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See GRIA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GRIA1

    SOURCE GeneReport for Unigene clusters: Hs.519693 Hs.737709

    UniProtKB/Swiss-Prot: GRIA1_HUMAN, P42261
    Tissue specificity: Widely expressed in brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including GRIA1: 
              Neurotransmitter Receptors in human mouse rat
              GABA & Glutamate in human mouse rat
              Synaptic Plasticity in human mouse rat

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    Orthologs
    for GRIA1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for GRIA1 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Gria11 , 5 glutamate receptor, ionotropic, AMPA1 (alpha 1)1, 5 90.4(n)1
    98.79(a)1    		   11 (34.51 cM)5
    147991  NM_001113325.21  NP_001106796.11 
     570113875 
    chicken
    (Gallus gallus)    		 Aves GRIA11 glutamate receptor, ionotropic, AMPA 1 84.04(n)
    94.01(a)    		   414893  NM_001001774.1  NP_001001774.1 
    lizard
    (Anolis carolinensis)    		 Reptilia GRIA16
    		 --
    		 88(a)
    		 1 ↔ 1
    		 GL343248.1(1696040-1850808)
    zebrafish
    (Danio rerio)    		 Actinopterygii AF525742.12   -- 77.18(n)    AF525742.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Glu-RIB3 alpha-amino-3-hydroxy-5-methyl-4-isoxazole
    propionate more    		 66(a)
    (best of 9)    		   67A4   --
    worm
    (Caenorhabditis elegans)    		 Secernentea glr-13 Expression: neurons, RMD neurons, SMD
    neurons, more    		 46(a)
    (best of 2)    		   III(8655978-8660337)   --


    ENSEMBL Gene Tree for GRIA1 (if available)
    TreeFam Gene Tree for GRIA1 (if available) 

    Paralogs
    for GRIA1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GRIA1 gene
    GRIA32  GRIN2D2  GRIK12  GRIA22  GRIK22  GRIN12  GRIK42  GRIK32  
    GRIN3A2  GRIN2B2  GRIN2A2  GRIK52  GRIN3B2  GRIN2C2  GRIA42  GRID12  
    GRID22  
    10 SIMAP similar genes for GRIA1 using alignment to 6 protein entries:     GRIA1_HUMAN (see all proteins):
    GRIA2    GRIA4    GRIA3    GRIK2    GRIK1    GRIK3
    GRID2    GRIK5    GRIK4    GRID1

    GRIA1 for paralogs           About GeneDecksing



    Genomic Variants
    for GRIA1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5672 NCBI SNPs in GRIA1 are shown (see all 5672)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs356972721,2
    		C--148296254(+) AACGG-/AAAAAA 1 -- int11Minor allele frequency- A:0.00CSA 2
    rs1854848501,2
    		--152868388(+) TTCCTA/GTGCTG 5 -- us2k10--------
    rs5482941,2
    		C,F,O,A,H,--152868437(-) TAATAG/ACAGCA 5 -- us2k136Minor allele frequency- A:0.33NS EA NA WA CSA 3085
    rs774054071,2
    		F,--152868503(+) CCAATC/GTCTTT 5 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1482535051,2
    		--152868577(+) TGAGGA/CTACCT 5 -- us2k10--------
    rs1127303141,2
    		--152868586(+) CTACAC/TAGGTA 5 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1503796811,2
    		--152868648(+) TCAAAA/GTAGTG 5 -- us2k10--------
    rs1380912551,2
    		--152868830(+) TGATAC/TACAGT 5 -- us2k10--------
    rs1419626341,2
    		--152868956(+) TCCTGA/GATCAT 6 -- us2k10--------
    rs1463168301,2
    		--152868979(+) AGGAGC/TCCTGG 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for GRIA1 (152869175 - 153119175 bp, first 250kb of GRIA1)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for GRIA1
         1 CNV: 3581
         1 Indel: 41332

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    Disorders / Diseases
    for GRIA1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GRIA1 for disorders           About GeneDecksing

    OMIM gene information: 138248    OMIM disorders: --

    20/30 diseases for GRIA1 (see all 30):    About MalaCards
    amyotrophic lateral sclerosis    amyotrophic lateral sclerosis (als)    temporal lobe epilepsy    lateral sclerosis
    limbic encephalitis    status epilepticus    fragile x syndrome    toxic encephalopathy
    alcohol abuse    anorexia nervosa    bipolar disorder    mood disorder
    brain disease    migraine    encephalitis    alzheimer's disease
    albinism    multiple sclerosis    tetanus    parkinson's disease

    4 diseases from the University of Copenhagen DISEASES database for GRIA1:
    Schizophrenia     Toxic encephalopathy     Parkinson's disease     Alzheimer's disease

    10/12 Novoseek disease relationships for GRIA1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 27.6 10 10588576 (3), 7969894 (2), 7542540 (2), 9466422 (1) (see all 5)
    schizophrenia 24.4 12 17942280 (3), 16526023 (3), 7609609 (2), 9099808 (1) (see all 5)
    bipolar disorder 21.9 2 17942280 (1), 18484081 (1)
    epilepsy 21.4 4 9455976 (2), 8985700 (2)
    drug withdrawal 19 2 9832144 (1), 16616767 (1)
    neurofibrillary tangles 17.6 1 7542540 (1)
    brain diseases 16 2 7969894 (1), 7542540 (1)
    amyotrophic lateral sclerosis 15.4 1 8981413 (1)
    tumors 0.737 1 18957620 (1)
    ischemia 0 6 11935066 (2), 12606709 (2), 10674477 (1)

    Human Genome Epidemiology (HuGE) Navigator: GRIA1 (14 documents)

    Export disorders for GRIA1 gene to outside databases

    Publications
    for GRIA1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GRIA1 gene, integrated from 9 sources (see all 327):
    (articles sorted by number of sources associating them with GRIA1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and chromosomal localization of one of the human glutamate receptor genes. (PubMed id 1652753)1, 2, 3 Puckett C.... Hood L.E. (1991)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors. (PubMed id 1311100)1, 2 Sun W.... Montal M. (1992)
    4. The human glutamate receptor cDNA GluR1: cloning, sequencing, expression and localization to chromosome 5. (PubMed id 1320959)1, 2 Potier M.-C.... Carter N.P. (1992)
    5. Chromosomal localization of human glutamate receptor genes. (PubMed id 1319477)1, 3 McNamara J.O....Heinemann S.F. (1992)
    6. Glutamate AMPA receptor subunit 1 gene (GRIA1) and DSM-IV-TR schizophrenia: a pilot case-control association study in an Italian sample. (PubMed id 16526023)1, 9 Magri C....Barlati S. (2006)
    7. AMPA receptors promote perivascular glioma invasion v ia beta1 integrin-dependent adhesion to the extracellular matrix. (PubMed id 18957620)1, 9 Piao Y....de Groot J. (2009)
    8. Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway. (PubMed id 11567040)1, 9 Sans N....Wenthold R.J. (2001)
    9. Identification of the Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate-type glutamate receptor. (PubMed id 9407043)1, 9 Barria A....Soderling T. (1997)
    10. Polymorphisms in the GRIA1 gene region in psychotic bipolar disorder. (PubMed id 18484081)1, 9 Kerner B....Freimer N.B. (2008)

    External Searches for GRIA1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GRIA1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2890 HGNC: 4571 AceView: GRIA1 Ensembl:ENSG00000155511 euGenes: HUgn2890
    ECgene: GRIA1 Kegg: 2890 H-InvDB: GRIA1

    Other Databases showing GRIA1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GRIA1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GRIA1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for GRIA1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GRIA1 gene:
    Search GeneIP for patents involving GRIA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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