GRHPR Gene
protein-coding GIFtS: 66
GCID: GC09P037412
|
|
glyoxylate reductase/hydroxypyruvate reductase
(Previous symbol: GLXR)
| |
Aliases
for GRHPR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Glyoxylate Reductase/Hydroxypyruvate Reductase1 2 | | Glycerate-2-Dehydrogenase1 | | GLXR1 2 3 5 | | EC 1.1.1.793 | | PH21 2 | | EC 1.1.1.813 | | GLYD2 | | |
Export aliases for GRHPR gene to outside databasesPrevious GC identifers: GC09P037734 GC09P037592 |
Summaries
for GRHPR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GRHPR:
This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenaseenzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluriais caused by mutations in this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: GRHPR_HUMAN, Q9UBQ7Function: Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymaticactivities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate
Gene Wiki entry for GRHPR
|
Genomic Views
for GRHPR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GRHPR gene promoter:
GR AML1a GR-beta Arnt Meis-1b COMP1 GR-alpha Meis-1a Pax-4a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for GRHPR
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRHPR |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q12 Ensembl cytogenetic band: 9p13.2 HGNC cytogenetic band: 9q12GRHPR Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P037412: view genomic region
(about GC identifiers)
Start:
|
37,422,663 bp from pter |
End:
|
37,436,987 bp from pter |
Size:
|
14,325 bases |
Orientation:
|
plus strand |
|
Proteins
for GRHPR gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GRHPR_HUMAN, Q9UBQ7 (See
protein sequence)Recommended Name: Glyoxylate reductase/hydroxypyruvate reductase Size: 328 amino acids; 35668 Da
Subunit: Homodimer
Sequence caution: Sequence=AAD54066.1; Type=Frameshift; Positions=109, 137; Sequence=AAG39286.1; Type=Frameshift;Positions=237;
4 PDB 3D structures from  and Proteopedia  for GRHPR:2GCG (3D)
2H1S (3D)
2Q50 (3D)
2WWR (3D)
Secondary accessions: Q5T945 Q9H3E9 Q9UKX1Explore the universe of human proteins at neXtProt for GRHPR: NX_Q9UBQ7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UBQ7
GRHPR Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036335.1
ENSEMBL proteins: ENSP00000367055 ENSP00000313432 ENSP00000432021 Reactome Protein details: Q9UBQ7
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
GRHPR for ontologies About GeneDecksing
GRHPR Antibody Products:
Assay Products for GRHPR: |
Protein
Domains /
Families
for GRHPR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GRHPR for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UBQ7ProtoNet protein and cluster: Q9UBQ7 1 Blocks protein family: IPB006139 D-isomer specific 2-hydroxyacid dehydrogenase
UniProtKB/Swiss-Prot: GRHPR_HUMAN, Q9UBQ7Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family |
Function
for GRHPR gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GRHPR_HUMAN, Q9UBQ7Function: Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymaticactivities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvateCatalytic activity: Glycolate + NADP(+) = glyoxylate + NADPHCatalytic activity: D-glycerate + NAD(P)(+) = hydroxypyruvate + NAD(P)H Genatlas biochemistry entry for GRHPR:glyoxylate reductase/hydroxypyruvate NADPH dependent,expressed in liver,kidney and blood
Enzyme Numbers (IUBMB): EC 1.1.1.811 EC 1.1.1.791
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRHPR (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRHPR
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: GRHPR (NM_012203) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GRHPR | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRHPR |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRHPR |
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table
GRHPR for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for GRHPR:
Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Grhpr):
GRHPR for phenotypes About GeneDecksing
|
Pathways & Interactions
for GRHPR gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Metabolism | | | 2 | Metabolism of amino acids and derivatives | | | 3 | Glyoxylate and dicarboxylate metabolism | | | 4 | Pyruvate metabolism | | | 5 | glycine biosynthesis III | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for GRHPR
3 
Kegg Pathways (Kegg details for GRHPR):
GRHPR for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GRHPR
STRING Interaction
Network Preview (showing 5 interactants - click image to see 22)
5/43 Interacting proteins for GRHPR (Q9UBQ73 ENSP000003134324) via UniProtKB, MINT, STRING, and/or I2D (see all 43)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
GRHPR for ontologies About GeneDecksing
|
Drugs & Compounds
for GRHPR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
GRHPR for compounds About GeneDecksing
 Browse Tocris compounds for GRHPR
10/11 HMDB Compounds for GRHPR (see all 11) About this table
4 Novoseek chemical compound relationships for GRHPR gene About this table
Search CenterWatch for drugs/clinical trials and news about GRHPR
|
Transcripts
for GRHPR gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GRHPR gene: NM_012203.1 Unigene Cluster for GRHPR: Glyoxylate reductase/hydroxypyruvate reductase Hs.155742 [show with all ESTs]Unigene Representative Sequence: AK02438610 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000493368(uc010mlu.3) ENST00000377824(uc010mlv.1) ENST00000318158(uc003zzt.1 uc003zzu.1)
ENST00000460882 ENST00000487399 ENST00000491488 ENST00000497693(uc003zzw.1)
ENST00000480596 ENST00000494290(uc003zzv.1) ENST00000482603
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRHPR (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRHPR
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GRHPR (NM_012203) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GRHPR | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRHPR |
Additional cDNA sequence: AF113215.1 AF113251.1 AF134895.1 AF146018.1 AK024386.1 AK025978.1 AK026287.1 AK026752.1 AK307325.1 AK307902.1 AK315690.1 BC000605.2 BC003131.1 BC088360.1 24/29 DOTS entries (see all 29): DT.100877522 DT.450034 DT.95373014 DT.121203439 DT.91979521 DT.100877527 DT.121203447 DT.121203396 DT.92454537 DT.97760135 DT.92454557 DT.100877532 DT.100711586 DT.100877530 DT.95215306 DT.100044466 DT.100877528 DT.121203383 DT.95373016 DT.100877526 DT.100877539 DT.100877540 DT.121203369 DT.121203381 24/631 AceView cDNA sequences (see all 631): BM712947 BI760532 BQ057359 CR597201 BQ919183 CA453913 T34009 NM_012203 BG055669 CR598870 CA397744 BF794690 CR591687 AI985881 AA256690 BQ063478 BE857144 AV656527 AI678784 BM725539 AF134895 CR599135 AI014882 CR602677
GeneLoc Exon Structure
5/17 Alternative Splicing Database (ASD) splice patterns (SP) for GRHPR (see all 17) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | - | | | | - | | - | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | - | | - | | - | | - | | | | | | - | | - | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | - | | - | | - | | - | | | | | | | | | | | |
| ExUns: | 7c | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 |
|---|
|
| SP1: | - | | - | | | | | | | | - | | | | | | | | | | | | |
| SP2: | - | | - | | | | | | | | - | | | | | | | | | | | | |
| SP3: | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | - | | - | | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for GRHPR
|
Expression
for GRHPR gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GRHPR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCTTGTTGG
About this image
See GRHPR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GRHPR
SOURCE GeneReport for Unigene cluster: Hs.155742
UniProtKB/Swiss-Prot: GRHPR_HUMAN, Q9UBQ7Tissue specificity: Ubiquitous. Most abundantly expressed in the liver
SABiosciences Custom PCR Arrays for GRHPR
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GRHPR
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GRHPR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRHPR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRHPR | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRHPR |
Orthologs
for GRHPR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for GRHPR gene from 8/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
GRHPR1 |
glyoxylate reductase/hydroxypyruvate reductase |
72.33(n)
75.62(a) |
|
426806 XM_424417.3 XP_424417.3 |
lizard
(Anolis carolinensis) |
Reptilia |
GRHPR6 |
-- |
73(a) |
1 ↔ 1 |
GL343201.1(3638486-3656570) |
African clawed frog
(Xenopus laevis) |
Amphibia |
LOC3985082 |
similar to glyoxylate reductase/hydroxypyruvate reductase |
74.5(n) |
|
BC045097.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb80f042 |
Danio rerio mRNA similar to glyoxylate reductase/hydroxypyruvate more |
72.76(n) |
|
BC052108.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG12361 , 3 |
phosphoglycerate dehydrogenase3
CG12361 |
53(a)
(best of 2)3
57.29(n)1
53.44(a)1 |
|
83C13
407081 NM_141322.11 NP_649579.21 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G798701 |
putative D-isomer specific 2-hydroxyacid dehydrogenase |
46.83(n)
40.08(a) |
|
844326 NM_106636.2 NP_178105.1 |
rice
(Oryza sativa) |
Liliopsida |
Os01g02286001 |
hypothetical protein |
50.06(n)
40.86(a) |
|
4327189 NM_001049014.1 NP_001042479.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
ghrB6 |
glyoxylate/hydroxypyruvate reductase B |
36(a) |
1 ↔ 1 |
Chromosome(3715333-3716307) |
ENSEMBL Gene Tree for GRHPR (if available)
TreeFam Gene Tree for GRHPR (if available) |
Paralogs
for GRHPR gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for GRHPR gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GRHPR (37422663 - 37436987 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GRHPR: --
Human Gene Mutation Database (HGMD): GRHPR
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GRHPR |
|
Disorders
/ Diseases
for GRHPR gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GRHPR for disorders About GeneDecksing
OMIM gene information: 604296
OMIM disorders: 260000
UniProtKB/Swiss-Prot: GRHPR_HUMAN, Q9UBQ7
Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2) [MIM:260000]; also known as primaryhyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalatenephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by anelevated urinary excretion of oxalate and L-glycerate
8  diseases for GRHPR: About MalaCardsprimary hyperoxaluria nephrocalcinosis peptic ulcer newcastle disease
follicular lymphoma nephrolithiasis convulsions hepatitis
3 diseases from the University of Copenhagen DISEASES database for GRHPR:Primary hyperoxaluria Nephrocalcinosis Nephrolithiasis 6 Novoseek disease relationships for GRHPR gene About this table
Genatlas disease: GRHPR hyperoxaluria primary type II,autosomal recessive,characterized by nephrolithiasis,nephorcalcinosis leading tooxalosis and renal failure
GeneTests: GRHPR
Hyperoxaluria, Primary, Type 2
Genetic Association Database (GAD): GRHPR
Human Genome Epidemiology (HuGE) Navigator: GRHPR (3 documents)
Export disorders for GRHPR gene to outside databases
|
Publications
for GRHPR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GRHPR gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with GRHPR) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II. (PubMed id 10484776)1, 2, 3, 9 Cramer S.D.... Holmes R.P. (1999)
- Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase. (PubMed id 10524214)1, 2, 3, 9 Rumsby G. and Cregeen D.P. (1999)
- Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase. (PubMed id 16756993)1, 2, 9 Booth M.P....Brady R.L. (2006)
- Evaluation of mutation screening as a first line test for the diagnosis of the primary hyperoxalurias. (PubMed id 15327387)1, 4, 9 Rumsby G....Coulter-Mackie M. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cloning and characterization of a putative human D-2-hydroxyacid dehydrogenase in chromosome 9q. (PubMed id 10679197)1, 2 Huang T.... Shih V.E. (2000)
- Late diagnosis of primary hyperoxaluria type 2 in the adult: effect of a novel mutation in GRHPR gene on enzymatic activity and molecular modeling. (PubMed id 19296982)1, 9 Levin-Iaina N....Holtzman E.J. (2009)
- Identification of missense, nonsense, and deletion mutations in the GRHPR gene in patients with primary hyperoxaluria type II (PH2). (PubMed id 11030416)1, 9 Webster K.E....Cramer S.D. (2000)
- A novel mutation in the GRHPR gene in a Japanese patient with primary hyperoxaluria type 2. (PubMed id 17510093)1, 9 Takayama T....Cramer S.D. (2007)
|
External Searches for GRHPR gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GRHPR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GRHPR gene
(According to HUGE)
About This Section
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Specialized Databases showing GRHPR gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for GRHPR | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/GRHPR |
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About This Section
| Patent Information for GRHPR gene:
Search GeneIP for patents involving GRHPR
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for GRHPR gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for GRHPR | | OriGene shRNA RFP for GRHPR | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GRHPR | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GRHPR | | | OriGene Protein Over-expression Lysate for GRHPR | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for GRHPR | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRHPR | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRHPR | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for GRHPR | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GRHPR | | OriGene Custom Protein Services for GRHPR | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GRHPR | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GRHPR | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRHPR | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRHPR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRHPR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRHPR |
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| | | | Search Tocris compounds for GRHPR |
| |  |  |  |  | | | | | | Recombinant Protein for GRHPR |
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 | | | GRHPR Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRHPR |
|  |  |  | | | | ThermoFisher Antibodies for GRHPR |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRHPR |
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