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RAPGEF1 Gene

protein-coding GIFtS: 65

GC09M133441

Rap guanine nucleotide exchange factor (GEF) 1
(Previous name: guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GRF2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
C3G ^¹, ², ⁵
DKFZp781P1719 ^²
GRF2 ^², ³, ⁵
OTTHUMP00000064558 ^²

Descriptions
C3G protein ^³
CRK SH3-binding GNRP ^³
Guanine nucleotide-releasing factor 2 ^², ³
Rap guanine nucleotide exchange factor (GEF) 1 ^²
Rap guanine nucleotide exchange factor 1 ^¹
guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene) ^¹, ²

External Ids
HGNC: 4568¹
Entrez Gene: 2889²
UniProtKB: Q13905³
Ensembl: ENSG00000107263⁷

Search outside databases for aliases for RAPGEF1 gene

Previous GC identifers: GC09M129729 GC09M131481

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for RAPGEF1:

This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by

binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This

signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and

cell transformation. Several alternatively spliced transcript variants of this gene have been

described, but the full-length nature of some variants has not been determined. [provided by

RefSeq]

UniProtKB/Swiss-Prot: RPGF1_HUMAN, Q13905

Function: Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH.

Transduces signals from CRK to activate RAS

Gene Wiki entry for RAPGEF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RAPGEF1 gene

Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.13 HGNC cytogenetic band: 9q34.3

RAPGEF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M133441: (about GC identifiers)

Start:	133,441,978 bp from pter
End:	133,605,282 bp from pter
Size:	163,305 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_035014.4

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RPGF1_HUMAN, Q13905 (See protein sequence)

Recommended Name: Rap guanine nucleotide exchange factor 1

Size: 1077 amino acids; 120548 Da

Subunit: Interacts with CRK via its SH3-binding sites

Secondary accessions: Q5JUE4

Alternative splicing: 2 isoforms: Q13905-1 Q13905-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_005303.2 NP_941372.1

ENSEMBL proteins:

ENSP00000361269 ENSP00000361263 ENSP00000266110 ENSP00000338266 ENSP00000350315 ENSP00000361264

ENSP00000361265 ENSP00000381451

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GRF2)
	Human Recombinant Proteins from Abnova (RAPGEF1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005768	endosome	EXP	7806500
GO:0005829	cytosol	EXP	16284401

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Antibodies for RAPGEF1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for RAPGEF1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (GRF2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RAPGEF1)
	Novus Biologicals Antibodies for RAPGEF1

Assays for RAPGEF1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13905

ProtoNet protein and cluster: Q13905

1 Blocks protein family: IPB001895 Guanine-nucleotide dissociation stimulator CDC25

UniProtKB/Swiss-Prot: RPGF1_HUMAN, Q13905

Similarity: Contains 1 N-terminal Ras-GEF domain

Similarity: Contains 1 Ras-GEF domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RAPGEF1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RAPGEF1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005312

Applied Biosystems Silencer® siRNAs for RAPGEF1

Sigma-Aldrich siRNA for RAPGEF1

Sigma-Aldrich shRNA for RAPGEF1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for RAPGEF1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005312
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005312
untagged cDNA clones in CMV expression vector (see all 3): BD140654

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_198679

UniProtKB/Swiss-Prot: RPGF1_HUMAN, Q13905

Function: Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH.

Transduces signals from CRK to activate RAS

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Rapgef1):

	cellular	embryogenesis	homeostasis/metabolism	lethality-prenatal/perinatal
muscle	nervous system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005085	guanyl-nucleotide exchange factor activity	IEA	--
GO:0005515	protein binding	IPI	9748234
GO:0017124	SH3 domain binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/8 Sigma-Aldrich "Your Favorite Gene" Pathways for RAPGEF1 (Your Favorite Gene powered by Ingenuity) (see all 8 )

ERK/MAPK Signaling
Renal Cell Carcinoma Signaling
Insulin Receptor Signaling
Ephrin Receptor Signaling
Integrin Signaling

GeneDecks RAPGEF1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for RAPGEF1

5/57 Interacting proteins for RAPGEF1 (ENSP00000338266³ Q13905^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 57 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABL1	P00519¹	STRING (score=.788) EBI-976876, EBI-375543
FYN	P06241¹	STRING (score=.745) EBI-976876, EBI-515315
NCK1	P16333¹	STRING (score=.765) EBI-976876, EBI-389883
SRC	P12931¹	STRING (score=.873) EBI-976876, EBI-621482
GRB2	P62993²	STRING (score=.995) MINT-14744 MINT-14745

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	TAS	7512734
GO:0051056	regulation of small GTPase mediated signal transduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for RAPGEF1

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RAPGEF1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RAPGEF1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RAPGEF1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005312

Sigma-Aldrich siRNA for RAPGEF1

Sigma-Aldrich shRNA for RAPGEF1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005312 NM_198679

REFSEQ mRNAs for RAPGEF1 gene (2 alternative transcripts):

NM_005312.2 NM_198679.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005312 NM_198679

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005312
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005312
                                 untagged cDNA clones in CMV expression vector (see all 3): BD140654

Additional cDNA sequence:

AJ420417.1 AK302763.1 BC041710.1 CR595928.1 CR749354.1 D21239.1 DQ925677.1 DQ925678.1

DQ925679.1 DQ925680.1 DQ925681.1 DQ925682.1 DQ925683.1 DQ925684.1

22 DOTS entries:

DT.92431967 DT.316981 DT.100779638 DT.40122665 DT.100779639 DT.426595 DT.86851760 DT.92060025

DT.92431968 DT.40315725 DT.407004 DT.75183099 DT.92034621 DT.95347072 DT.100738450 DT.121160998

DT.92431972 DT.97781075 DT.100776031 DT.101954250 DT.92004610 DT.95270527

24/320 AceView cDNA sequences (see all 320 ):

AF467069 BM725619 BQ070501 T12646 BQ054243 BU521008 BC041710 CR595928

AW504921 BE882072 BU430359 W57969 AW500020 BQ894870 BX097548 T11437

BM914033 BG056481 AA300930 BX328263 BQ222795 BQ711000 BE018171 BQ924723

highest scoring ESTs for RAPGEF1:

D21239 AA761259 AI817130 N36445 AA086166 AA128426 AA258933 AA300930 AA318682 AA324476

Unigene Cluster for RAPGEF1:

Rap guanine nucleotide exchange factor (GEF) 1

Hs.127897 [show with all ESTs]

Unigene Representative Sequence: NM_198679

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RAPGEF1 (see all 8 )

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18a	·	18b	^	19	^	20a	·
SP1:			-		-		-				-																								-														-		-
SP2:					-		-				-																								-														-		-
SP3:																																													-				-		-
SP4:											-		-
SP5:

ExUns:	20b	^	21a	·	21b	·	21c	^	22	^	23a	·	23b	^	24	^	25	^	26	^	27	^	28a	·	28b
SP1:			-
SP2:			-
SP3:			-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for RAPGEF1

8 Ensembl transcripts including schematic representations:

ENST00000372195 ENST00000372189 ENST00000266110 ENST00000337036 ENST00000357686 ENST00000372190

ENST00000372191 ENST00000398415

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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RAPGEF1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RAPGEF1

¹ / ² / ³

11 probe-sets matching RAPGEF1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
78805_at²^{, 3}	U95-E	1	1.00	1.00	0.88	1.11	N36445	0.80	1.00	0.91	1
36240_at²^{, 3}	U95-A	1	1.00	1.00	0.86	0.43	D21239	1.00	0.90	0.95	1
65978_at²^{, 3}	U95-C	2	1.00	0.97	0.85	1.30	AI817130	0.80	1.00	0.91	1
51157_at²^{, 3}	U95-C	1	0.88	1.00	0.91	1.24	AA761259	0.80	1.00	0.91	1
89697_at²^{, 3}	U95-D	1	0.38	1.00	0.74	0.94	AA195265	0.40	1.00	0.76	1
225738_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA761259	0.80	1.00	0.91	1
226389_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AU158380	0.20	1.00	0.72	1
204543_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005312	0.60	1.00	0.82	1
225738_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
226389_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204543_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks RAPGEF1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.127897
Expression variation in blood from EXPOLDB for RAPGEF1
UniProtKB/Swiss-Prot: RPGF1_HUMAN, Q13905
Tissue specificity: Ubiquitously expressed in adult and fetus. Expression is high in adult skeletal
muscle and placenta and in fetal brain and heart. Low levels of expression in adult and fetal
liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RAPGEF1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RAPGEF1¹	--	Rap guanine nucleotide exchange factor (GEF) 1	90.04(n) 93.83(a)	491286 XM_548407.2 XP_548407.2
chimpanzee (Pan troglodytes)	RAPGEF1¹	--	Rap guanine nucleotide exchange factor (GEF) 1	99.45(n) 99.54(a)	464812 XM_001167804.1 XP_001167804.1
cow (Bos taurus)	RAPGEF1¹	--	Rap guanine nucleotide exchange factor (GEF) 1	89(n) 92.96(a)	520454 XM_598698.3 XP_598698.3
mouse (Mus musculus)	Rapgef1^{1, 5}	2 (18.50 cM)⁵	Rap guanine nucleotide exchange factor (GEF) 1^{1, 5}	87.52(n)¹ 92.88(a)¹	107746¹ NM_054050.2¹ NP_473391.1¹ AA014600⁵ AF348669⁵ (see all 20)
chicken (Gallus gallus)	RAPGEF1¹	--	Rap guanine nucleotide exchange factor (GEF) 1	79.21(n) 85.85(a)	417173 XM_415456.2 XP_415456.2

About this table Species with no ortholog for RAPGEF1

ENSEMBL Gene Tree for RAPGEF1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for RAPGEF1 gene

SOS2² SOS1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/921 NCBI SNPs in RAPGEF1 are shown (see all 921 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 328)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs943851^1,2	A,C,F,H	133442502(-)	`CCTCAT/CTGGGA`	2	--	ut3¹ ese³		6	MN EU EA WA	2076
	rs4740181^1,2	A,C,F,H	133603794(+)	`TGCTGG/TCTGGA`	1	--	ng3¹		4	EU EA WA	418
	rs7030401^1,2	A,C,F,H	133441664(+)	`CACCCG/AAGGAA`	2	--	ng5¹		8	EU EA WA NA	778
	rs7034382^1,2	A,C,F,H	133602786(+)	`CAGGTA/CTTTCT`	1	--	ng3¹ trp³		4	EU EA WA	420
	rs11243438^1,2	A,C,F,H	133441704(+)	`GGGCTC/GTTGTG`	2	--	ng5¹		4	EU EA WA	420
	rs3739497^1,2	A,C,F,H	133443797(-)	`TCCATC/TGCTCG`	2	--	ut3¹ ese³		15	EA NA EU WA	2726
	rs17553234^1,2	C,F,H	133575559(+)	`AGAATT/CTATAA`	2	--	ng3¹ int¹		11	NA EU EA WA	980
	rs17462026^1,2	C,F,H	133576991(+)	`AATGGG/AAGCAA`	2	--	int¹ ng3¹		7	NA EU EA WA	558
	rs928014^1,2	A,C,H	133604141(+)	`CTACCT/GGGGTT`	1	--	ng3¹		2	MN EU	304
	rs11792068^1,2	C,F,H	133575606(+)	`ATTTTG/ACTGGA`	2	--	ng3¹ int¹		4	EU EA WA	420

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HapMap Linkage Disequilibrium images for RAPGEF1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600303

Human Genome Epidemiology Navigator: RAPGEF1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/48 PubMed articles for RAPGEF1 gene (see all 48 ):

C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins. (PubMed id 7512734)^{2, 3, 4} Tanaka S....Nagashima K. (1994)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. (PubMed id 8662907)^{3, 4} Matsuda M.... Kurata T. (1996)
Mapping of the human C3G gene coding a guanine nucleotide releasing protein for Ras family to 9q34.3 by fluorescence in situ hybridization. (PubMed id 7959692)^{2, 3} Takai S....Matsuda M. (1994)
Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk. (PubMed id 7806500)^{3, 4} Knudsen B.... Hanafusa H. (1994)
RAPGEF1 gene variants associated with type 2 diabetes in the Korean population. (PubMed id 19297053)^{1, 3} Hong K.W....Oh B. (2009)
Phosphorylated guanine nucleotide exchange factor C3G, induced by pervanadate and Src family kinases localizes to the Golgi and subcortical actin cytoskeleton. (PubMed id 15320955)^{1, 3} Radha V....Swarup G. (2004)
The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1. (PubMed id 18809728)³ Nolz J.C....Billadeau D.D. (2008)
Rap1 activation is required for Fc gamma receptor-dependent phagocytosis. (PubMed id 18832707)³ Chung J....Peters-Golden M. (2008)
Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)³ Lu Y....Boer J.M. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2889	HGNC: 4568	AceView: RAPGEF1	Ensembl:ENSG00000107263	euGenes: HUgn2889
ECgene: RAPGEF1	H-InvDB: RAPGEF1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for RAPGEF1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for RAPGEF1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for RAPGEF1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RAPGEF1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RAPGEF1		Antibodies for RAPGEF1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RAPGEF1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (RAPGEF1)
	Antibodies (RAPGEF1)
	Chimera RNAi (RAPGEF1)
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RAPGEF1 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for RAPGEF1

Summaries
for RAPGEF1

Genomic Location
for RAPGEF1

Proteins
for RAPGEF1

Protein Domains/
Families
for RAPGEF1

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for RAPGEF1

Pathways & Interactions
for RAPGEF1

Drugs & Compounds
for RAPGEF1

Transcripts
for RAPGEF1

Expression
for RAPGEF1

Orthologs
for RAPGEF1

Paralogs
for RAPGEF1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RAPGEF1 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor RAPGEF1

Summariesfor RAPGEF1

Genomic Locationfor RAPGEF1

Proteinsfor RAPGEF1

Protein Domains/Familiesfor RAPGEF1

Gene Functionfor RAPGEF1

Pathways & Interactionsfor RAPGEF1

Drugs & Compoundsfor RAPGEF1

Transcriptsfor RAPGEF1

Expression for RAPGEF1

Orthologsfor RAPGEF1

Paralogsfor RAPGEF1

SNPs/Variantsfor RAPGEF1

Disorders & Mutationsfor RAPGEF1

Medical Newsfor RAPGEF1

Publicationsfor RAPGEF1

Search for RAPGEF1

Genome Databases showing RAPGEF1

Other Databases showing RAPGEF1

Specialized Databases showing RAPGEF1

Licensable Technologiesfor RAPGEF1

Servicesfor RAPGEF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RAPGEF1

Summaries
for RAPGEF1

Genomic Location
for RAPGEF1

Proteins
for RAPGEF1

Protein Domains/
Families
for RAPGEF1

Gene Function
for RAPGEF1

Pathways & Interactions
for RAPGEF1

Drugs & Compounds
for RAPGEF1

Transcripts
for RAPGEF1

Expression
for RAPGEF1

Orthologs
for RAPGEF1

Paralogs
for RAPGEF1

SNPs/Variants
for RAPGEF1

Disorders & Mutations
for RAPGEF1

Medical News
for RAPGEF1

Publications
for RAPGEF1

Licensable Technologies
for RAPGEF1

Services
for RAPGEF1