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Aliases for GREB1L Gene

Aliases for GREB1L Gene

  • Growth Regulation By Estrogen In Breast Cancer 1 Like 2 3 5
  • KIAA1772 2 3 4
  • Growth Regulation By Estrogen In Breast Cancer-Like 2 3
  • C18orf6 3 4
  • GREB1-Like Protein 3

External Ids for GREB1L Gene

Previous HGNC Symbols for GREB1L Gene

  • KIAA1772

Previous GeneCards Identifiers for GREB1L Gene

  • GC18P017077
  • GC18P018823
  • GC18P015669

Summaries for GREB1L Gene

GeneCards Summary for GREB1L Gene

GREB1L (Growth Regulation By Estrogen In Breast Cancer 1 Like) is a Protein Coding gene. An important paralog of this gene is GREB1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GREB1L Gene

Genomics for GREB1L Gene

Regulatory Elements for GREB1L Gene

Enhancers for GREB1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F021265 0.4 ENCODE 11.8 +24.6 24601 1.8 SOX13 HLF GLIS1 CEBPG GREB1L LOC101927496 ENSG00000265948
GH18F021264 0.4 ENCODE 11.8 +22.5 22532 0.9 SOX13 PKNOX1 SAP130 ARID4B CEBPG RAD21 TEAD3 YY1 HNF4G MIXL1 GREB1L LOC101927496 ENSG00000265948
GH18F021184 0.2 ENCODE 10.6 -57.6 -57648 0.2 ZNF217 GATA3 JUND CTBP1 CUX1 DPF2 TCF7L2 GREB1L EXOGP1
GH18F022031 0.8 Ensembl ENCODE 4.9 +790.3 790271 2.3 HDAC1 PKNOX1 KLF17 SIN3A FEZF1 ZNF121 ZNF366 RCOR1 FOS EGR2 GREB1L RNU7-17P LINC01900
GH18F021450 0.5 ENCODE 4.7 +210.3 210317 3.1 RFX1 PRDM10 MYC GREB1L LOC101927521 GC18P021594
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GREB1L on UCSC Golden Path with GeneCards custom track

Promoters for GREB1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000522907 258 2200 ZNF76 ZNF48 RAD21 GLIS2 ZNF263 SMARCC1 PPARG ZNF585B ZNF341 GLIS1

Genomic Location for GREB1L Gene

21,242,242 bp from pter
21,525,423 bp from pter
283,182 bases
Plus strand

Genomic View for GREB1L Gene

Genes around GREB1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GREB1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GREB1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GREB1L Gene

Proteins for GREB1L Gene

  • Protein details for GREB1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GREB1-like protein
    Protein Accession:
    Secondary Accessions:
    • A4QN17
    • Q9H8F1

    Protein attributes for GREB1L Gene

    1923 amino acids
    Molecular mass:
    214354 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI25018.1; Type=Frameshift; Positions=591; Evidence={ECO:0000305}; Sequence=BAB14666.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAB14666.1; Type=Frameshift; Positions=675; Evidence={ECO:0000305}; Sequence=BAB21863.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB21863.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Spurious priming from an intronic poly-A tract.; Evidence={ECO:0000305};

    Alternative splice isoforms for GREB1L Gene


neXtProt entry for GREB1L Gene

Post-translational modifications for GREB1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GREB1L Gene

Domains & Families for GREB1L Gene

Protein Domains for GREB1L Gene


Suggested Antigen Peptide Sequences for GREB1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GREB1 family.
  • Belongs to the GREB1 family.
genes like me logo Genes that share domains with GREB1L: view

No data available for Gene Families for GREB1L Gene

Function for GREB1L Gene

genes like me logo Genes that share phenotypes with GREB1L: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GREB1L Gene

Localization for GREB1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for GREB1L Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GREB1L Gene COMPARTMENTS Subcellular localization image for GREB1L gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GREB1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GREB1L: view

Pathways & Interactions for GREB1L Gene

SuperPathways for GREB1L Gene

No Data Available

Interacting Proteins for GREB1L Gene

Selected Interacting proteins: Q9C091-GRB1L_HUMAN for GREB1L Gene via IID

Gene Ontology (GO) - Biological Process for GREB1L Gene


No data available for Pathways by source and SIGNOR curated interactions for GREB1L Gene

Transcripts for GREB1L Gene

Unigene Clusters for GREB1L Gene

Growth regulation by estrogen in breast cancer-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GREB1L Gene

No ASD Table

Relevant External Links for GREB1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GREB1L Gene

mRNA expression in normal human tissues for GREB1L Gene

mRNA differential expression in normal tissues according to GTEx for GREB1L Gene

This gene is overexpressed in Muscle - Skeletal (x4.2).

Protein differential expression in normal tissues from HIPED for GREB1L Gene

This gene is overexpressed in Colon (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GREB1L Gene

Protein tissue co-expression partners for GREB1L Gene

NURSA nuclear receptor signaling pathways regulating expression of GREB1L Gene:


SOURCE GeneReport for Unigene cluster for GREB1L Gene:

genes like me logo Genes that share expression patterns with GREB1L: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GREB1L Gene

Orthologs for GREB1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for GREB1L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GREB1L 34 35
  • 99.51 (n)
(Canis familiaris)
Mammalia GREB1L 34 35
  • 91.97 (n)
(Bos Taurus)
Mammalia GREB1L 34 35
  • 88.83 (n)
(Rattus norvegicus)
Mammalia Greb1l 34
  • 88.04 (n)
(Monodelphis domestica)
Mammalia GREB1L 35
  • 88 (a)
(Mus musculus)
Mammalia Greb1l 34 16 35
  • 87.67 (n)
(Ornithorhynchus anatinus)
Mammalia GREB1L 35
  • 81 (a)
(Gallus gallus)
Aves GREB1L 34 35
  • 79.38 (n)
(Anolis carolinensis)
Reptilia GREB1L 35
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia greb1l 34
  • 70.96 (n)
(Danio rerio)
Actinopterygii greb1l 34 35
  • 64.74 (n)
Species where no ortholog for GREB1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GREB1L Gene

Gene Tree for GREB1L (if available)
Gene Tree for GREB1L (if available)

Paralogs for GREB1L Gene

Paralogs for GREB1L Gene

(1) SIMAP similar genes for GREB1L Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GREB1L: view

Variants for GREB1L Gene

Sequence variations from dbSNP and Humsavar for GREB1L Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1006260 -- 21,478,058(-) AGAGG(A/G)CAATA intron-variant
rs1006934 -- 21,476,100(+) GGGGT(C/G)GGGGG intron-variant
rs10084015 -- 21,405,692(+) GCTAT(C/T)TGGGA intron-variant
rs10084017 -- 21,408,105(+) tagaa(A/G)agaag intron-variant
rs10084018 -- 21,408,147(+) agata(A/G)atgtt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GREB1L Gene

Variant ID Type Subtype PubMed ID
esv2716846 CNV deletion 23290073
esv2716847 CNV deletion 23290073
esv3555124 CNV deletion 23714750
esv3641936 CNV loss 21293372
esv3641937 CNV loss 21293372
esv3641938 CNV gain 21293372
esv7076 CNV gain 19470904
nsv1058549 CNV gain 25217958
nsv1066370 CNV gain 25217958
nsv1071443 CNV deletion 25765185
nsv1077678 CNV insertion 25765185
nsv132210 CNV deletion 16902084
nsv2220 CNV deletion 18451855
nsv509686 CNV insertion 20534489
nsv833595 CNV loss 17160897

Variation tolerance for GREB1L Gene

Gene Damage Index Score: 3.77; 58.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GREB1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GREB1L Gene

Disorders for GREB1L Gene

Relevant External Links for GREB1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GREB1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GREB1L Gene

Publications for GREB1L Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
  4. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C. … Lander E.S. (Nature 2005) 4 64
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3 64

Products for GREB1L Gene

Sources for GREB1L Gene

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