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Aliases for GREB1L Gene

Aliases for GREB1L Gene

  • Growth Regulation By Estrogen In Breast Cancer-Like 2 3 5
  • KIAA1772 2 3 4
  • C18orf6 3 4

External Ids for GREB1L Gene

Previous HGNC Symbols for GREB1L Gene

  • KIAA1772

Previous GeneCards Identifiers for GREB1L Gene

  • GC18P017077
  • GC18P018823
  • GC18P015669

Summaries for GREB1L Gene

GeneCards Summary for GREB1L Gene

GREB1L (Growth Regulation By Estrogen In Breast Cancer-Like) is a Protein Coding gene. An important paralog of this gene is GREB1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GREB1L Gene

Genomics for GREB1L Gene

Regulatory Elements for GREB1L Gene

Enhancers for GREB1L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GREB1L on UCSC Golden Path with GeneCards custom track

Promoters for GREB1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GREB1L on UCSC Golden Path with GeneCards custom track

Genomic Location for GREB1L Gene

Chromosome:
18
Start:
21,242,242 bp from pter
End:
21,525,423 bp from pter
Size:
283,182 bases
Orientation:
Plus strand

Genomic View for GREB1L Gene

Genes around GREB1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GREB1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GREB1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GREB1L Gene

Proteins for GREB1L Gene

  • Protein details for GREB1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C091-GRB1L_HUMAN
    Recommended name:
    GREB1-like protein
    Protein Accession:
    Q9C091
    Secondary Accessions:
    • A4QN17
    • Q9H8F1

    Protein attributes for GREB1L Gene

    Size:
    1923 amino acids
    Molecular mass:
    214354 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI25018.1; Type=Frameshift; Positions=591; Evidence={ECO:0000305}; Sequence=BAB14666.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAB14666.1; Type=Frameshift; Positions=675; Evidence={ECO:0000305}; Sequence=BAB21863.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB21863.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Spurious priming from an intronic poly-A tract.; Evidence={ECO:0000305};

    Alternative splice isoforms for GREB1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GREB1L Gene

Proteomics data for GREB1L Gene at MOPED

Post-translational modifications for GREB1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GREB1L Gene

No data available for DME Specific Peptides for GREB1L Gene

Domains & Families for GREB1L Gene

Protein Domains for GREB1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GREB1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C091

UniProtKB/Swiss-Prot:

GRB1L_HUMAN :
  • Belongs to the GREB1 family.
Family:
  • Belongs to the GREB1 family.
genes like me logo Genes that share domains with GREB1L: view

No data available for Gene Families for GREB1L Gene

Function for GREB1L Gene

genes like me logo Genes that share phenotypes with GREB1L: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GREB1L Gene

Localization for GREB1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for GREB1L Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GREB1L Gene COMPARTMENTS Subcellular localization image for GREB1L gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for GREB1L Gene

Pathways & Interactions for GREB1L Gene

SuperPathways for GREB1L Gene

No Data Available

Interacting Proteins for GREB1L Gene

Gene Ontology (GO) - Biological Process for GREB1L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GREB1L Gene

Drugs & Compounds for GREB1L Gene

No Compound Related Data Available

Transcripts for GREB1L Gene

Unigene Clusters for GREB1L Gene

Growth regulation by estrogen in breast cancer-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GREB1L Gene

No ASD Table

Relevant External Links for GREB1L Gene

GeneLoc Exon Structure for
GREB1L
ECgene alternative splicing isoforms for
GREB1L

Expression for GREB1L Gene

mRNA expression in normal human tissues for GREB1L Gene

mRNA differential expression in normal tissues according to GTEx for GREB1L Gene

This gene is overexpressed in Muscle - Skeletal (x4.2).

Protein differential expression in normal tissues from HIPED for GREB1L Gene

This gene is overexpressed in Colon (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for GREB1L Gene



SOURCE GeneReport for Unigene cluster for GREB1L Gene Hs.149020

genes like me logo Genes that share expression patterns with GREB1L: view

Protein tissue co-expression partners for GREB1L Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GREB1L Gene

Orthologs for GREB1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for GREB1L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GREB1L 35
  • 88.83 (n)
  • 92.66 (a)
GREB1L 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GREB1L 35
  • 91.97 (n)
  • 94.9 (a)
GREB1L 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Greb1l 35
  • 87.67 (n)
  • 90.84 (a)
Greb1l 16
Greb1l 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GREB1L 35
  • 99.51 (n)
  • 99.58 (a)
GREB1L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Greb1l 35
  • 88.04 (n)
  • 91.76 (a)
oppossum
(Monodelphis domestica)
Mammalia GREB1L 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GREB1L 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves GREB1L 35
  • 79.38 (n)
  • 85.65 (a)
GREB1L 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GREB1L 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia greb1l 35
  • 70.96 (n)
  • 75.37 (a)
zebrafish
(Danio rerio)
Actinopterygii greb1l 35
  • 64.74 (n)
  • 65.52 (a)
greb1l 36
  • 61 (a)
ManyToMany
Species with no ortholog for GREB1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GREB1L Gene

ENSEMBL:
Gene Tree for GREB1L (if available)
TreeFam:
Gene Tree for GREB1L (if available)

Paralogs for GREB1L Gene

Paralogs for GREB1L Gene

(1) SIMAP similar genes for GREB1L Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GREB1L: view

Variants for GREB1L Gene

Sequence variations from dbSNP and Humsavar for GREB1L Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs7231015 -- 21,521,961(+) attgc(A/G)ctact intron-variant
rs1701563 -- 21,482,870(-) TATTT(C/T)TGGGG intron-variant
rs1701565 -- 21,522,005(-) ttttt(G/T)ggaga intron-variant
rs7232597 -- 21,248,408(+) aTCTG(A/G)AAGCC intron-variant
rs7232872 -- 21,524,942(+) CAGTA(C/T)AATTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GREB1L Gene

Variant ID Type Subtype PubMed ID
nsv833595 CNV Loss 17160897
nsv909448 CNV Gain 21882294
esv2716846 CNV Deletion 23290073
esv2716847 CNV Deletion 23290073
nsv909449 CNV Gain 21882294
nsv509686 CNV Insertion 20534489
nsv2220 CNV Loss 18451855
esv7076 CNV Gain 19470904
nsv132210 CNV Loss 16902084

Variation tolerance for GREB1L Gene

Gene Damage Index Score: 3.77; 58.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GREB1L Gene

HapMap Linkage Disequilibrium report
GREB1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GREB1L Gene

Disorders for GREB1L Gene

Relevant External Links for GREB1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GREB1L

No disorders were found for GREB1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GREB1L Gene

Publications for GREB1L Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for GREB1L Gene

Sources for GREB1L Gene

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