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Aliases for GREB1 Gene

Aliases for GREB1 Gene

  • Growth Regulation By Estrogen In Breast Cancer 1 2 3 5
  • Gene Regulated By Estrogen In Breast Cancer 2
  • Gene Regulated In Breast Cancer 1 Protein 4
  • KIAA0575 4

External Ids for GREB1 Gene

Previous GeneCards Identifiers for GREB1 Gene

  • GC02P011537
  • GC02P011725
  • GC02P011695
  • GC02P011624
  • GC02P011591
  • GC02P011674
  • GC02P011524
  • GC02P011536

Summaries for GREB1 Gene

Entrez Gene Summary for GREB1 Gene

  • This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GREB1 Gene

GREB1 (Growth Regulation By Estrogen In Breast Cancer 1) is a Protein Coding gene. Diseases associated with GREB1 include Breast Cancer. An important paralog of this gene is GREB1L.

UniProtKB/Swiss-Prot for GREB1 Gene

  • May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GREB1 Gene

Genomics for GREB1 Gene

Regulatory Elements for GREB1 Gene

Enhancers for GREB1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GREB1 on UCSC Golden Path with GeneCards custom track

Promoters for GREB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GREB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GREB1 Gene

Chromosome:
2
Start:
11,482,341 bp from pter
End:
11,642,788 bp from pter
Size:
160,448 bases
Orientation:
Plus strand

Genomic View for GREB1 Gene

Genes around GREB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GREB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GREB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GREB1 Gene

Proteins for GREB1 Gene

  • Protein details for GREB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4ZG55-GREB1_HUMAN
    Recommended name:
    Protein GREB1
    Protein Accession:
    Q4ZG55
    Secondary Accessions:
    • A6NHD0
    • A6NKN0
    • B5MDA9
    • O60321
    • Q7Z5S2
    • Q9H2Q6
    • Q9H2Q7
    • Q9H2Q8

    Protein attributes for GREB1 Gene

    Size:
    1949 amino acids
    Molecular mass:
    216467 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA25501.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GREB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GREB1 Gene

Proteomics data for GREB1 Gene at MOPED

Post-translational modifications for GREB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GREB1 Gene

Domains & Families for GREB1 Gene

Protein Domains for GREB1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GREB1 Gene

Graphical View of Domain Structure for InterPro Entry

Q4ZG55

UniProtKB/Swiss-Prot:

GREB1_HUMAN :
  • Belongs to the GREB1 family.
Family:
  • Belongs to the GREB1 family.
genes like me logo Genes that share domains with GREB1: view

No data available for Gene Families for GREB1 Gene

Function for GREB1 Gene

Molecular function for GREB1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.
UniProtKB/Swiss-Prot Induction:
Estrogen-responsive; regulated by estrogen receptors. Regulated by androgens. The regulatory region of the gene contains 3 estrogen-responsive elements.
genes like me logo Genes that share phenotypes with GREB1: view

Animal Models for GREB1 Gene

MGI Knock Outs for GREB1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GREB1 Gene

Localization for GREB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GREB1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GREB1 Gene COMPARTMENTS Subcellular localization image for GREB1 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 2
mitochondrion 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with GREB1: view

Pathways & Interactions for GREB1 Gene

SuperPathways for GREB1 Gene

No Data Available

Interacting Proteins for GREB1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000234142%0d%0a9606.ENSP00000206249%0d%0a
Selected Interacting proteins: ENSP00000234142 for GREB1 Gene via STRING

Symbol External ID(s) Details
ESR1

Gene Ontology (GO) - Biological Process for GREB1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GREB1 Gene

Drugs & Compounds for GREB1 Gene

No Compound Related Data Available

Transcripts for GREB1 Gene

Unigene Clusters for GREB1 Gene

Growth regulation by estrogen in breast cancer 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GREB1 Gene

No ASD Table

Relevant External Links for GREB1 Gene

GeneLoc Exon Structure for
GREB1
ECgene alternative splicing isoforms for
GREB1

Expression for GREB1 Gene

mRNA expression in normal human tissues for GREB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GREB1 Gene

This gene is overexpressed in Ovary (x17.0) and Prostate (x5.0).

Protein differential expression in normal tissues from HIPED for GREB1 Gene

This gene is overexpressed in Esophagus (30.5), Retina (29.4), and Ovary (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GREB1 Gene



SOURCE GeneReport for Unigene cluster for GREB1 Gene Hs.467733

mRNA Expression by UniProt/SwissProt for GREB1 Gene

Q4ZG55-GREB1_HUMAN
Tissue specificity: Expressed in proliferating prostatic tissue and prostate cancer.
genes like me logo Genes that share expression patterns with GREB1: view

Primer Products

No data available for Protein tissue co-expression partners for GREB1 Gene

Orthologs for GREB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GREB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GREB1 35
  • 87.59 (n)
  • 91.49 (a)
GREB1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GREB1 35
  • 88.34 (n)
  • 91.93 (a)
GREB1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Greb1 35
  • 84.86 (n)
  • 88.95 (a)
Greb1 16
Greb1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GREB1 35
  • 99.3 (n)
  • 99.26 (a)
GREB1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Greb1 35
  • 84.42 (n)
  • 88.51 (a)
oppossum
(Monodelphis domestica)
Mammalia GREB1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
chicken
(Gallus gallus)
Aves GREB1 35
  • 72.25 (n)
  • 80 (a)
GREB1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GREB1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia greb1 35
  • 68.18 (n)
  • 70.04 (a)
Str.16465 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.13835 35
zebrafish
(Danio rerio)
Actinopterygii Dr.17964 35
greb1 35
  • 65.64 (n)
  • 65.17 (a)
greb1 36
  • 61 (a)
OneToOne
Species with no ortholog for GREB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GREB1 Gene

ENSEMBL:
Gene Tree for GREB1 (if available)
TreeFam:
Gene Tree for GREB1 (if available)

Paralogs for GREB1 Gene

Paralogs for GREB1 Gene

(1) SIMAP similar genes for GREB1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for GREB1 Gene

genes like me logo Genes that share paralogs with GREB1: view

Variants for GREB1 Gene

Sequence variations from dbSNP and Humsavar for GREB1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10929757 - 11,562,535(+) CCCAA(A/C)CCCTT nc-transcript-variant, reference, missense
rs4669751 - 11,566,567(+) GGGGG(C/T)CAAGT nc-transcript-variant, reference, missense
rs6744817 - 11,585,782(+) CCTGC(A/G)TGCCG nc-transcript-variant, reference, missense
rs3762579 - 11,610,939(-) CCAGC(C/T)GGGCC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs11695925 - 11,627,043(+) AGCGT(A/G)CAACA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GREB1 Gene

Variant ID Type Subtype PubMed ID
nsv873663 CNV Loss 21882294
esv2719672 CNV Deletion 23290073
esv2719674 CNV Deletion 23290073
esv2719675 CNV Deletion 23290073
esv2719676 CNV Deletion 23290073
esv1008112 CNV Insertion 20482838
esv1626684 CNV Insertion 17803354
esv1172824 CNV Insertion 17803354
esv1662162 CNV Insertion 17803354
esv1097706 CNV Insertion 17803354

Variation tolerance for GREB1 Gene

Residual Variation Intolerance Score: 83.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.48; 99.11% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GREB1 Gene

Disorders for GREB1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GREB1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search GREB1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GREB1

Genetic Association Database (GAD)
GREB1
Human Genome Epidemiology (HuGE) Navigator
GREB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GREB1
genes like me logo Genes that share disorders with GREB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GREB1 Gene

Publications for GREB1 Gene

  1. PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone- responsive breast cancer. (PMID: 11103799) Ghosh M.G. … Weigel R.J. (Cancer Res. 2000) 2 3 4 23 67
  2. Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R. … Aloy P. (J. Mol. Biol. 2015) 3
  3. Functional evaluation of genetic variants associated with endometriosis near GREB1. (PMID: 25788566) Fung J.N. … Montgomery G.W. (Hum. Reprod. 2015) 3
  4. 17I^-estradiol upregulates GREB1 and accelerates ovarian tumor progression in vivo. (PMID: 24469735) Laviolette L.A. … Vanderhyden B.C. (Int. J. Cancer 2014) 3
  5. Consideration of GREB1 as a potential therapeutic target for hormone-responsive or endocrine-resistant cancers. (PMID: 24998469) Hodgkinson K.M. … Vanderhyden B.C. (Expert Opin. Ther. Targets 2014) 3

Products for GREB1 Gene

Sources for GREB1 Gene

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