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Aliases for GRB7 Gene

Aliases for GRB7 Gene

  • Growth Factor Receptor Bound Protein 7 2 3 5
  • Epidermal Growth Factor Receptor GRB-7 3 4
  • GRB7 Adapter Protein 3 4
  • B47 3 4
  • Growth Factor Receptor-Bound Protein 7 2

External Ids for GRB7 Gene

Previous GeneCards Identifiers for GRB7 Gene

  • GC17M037569
  • GC17P039891
  • GC17P037804
  • GC17P038269
  • GC17P035147
  • GC17P037894
  • GC17P033688

Summaries for GRB7 Gene

Entrez Gene Summary for GRB7 Gene

  • The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for GRB7 Gene

GRB7 (Growth Factor Receptor Bound Protein 7) is a Protein Coding gene. Diseases associated with GRB7 include Silver-Russell Syndrome and Breast Cancer. Among its related pathways are EPH-Ephrin signaling and Akt Signaling Pathway. GO annotations related to this gene include identical protein binding and protein kinase binding. An important paralog of this gene is GRB14.

UniProtKB/Swiss-Prot for GRB7 Gene

  • Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).

Gene Wiki entry for GRB7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRB7 Gene

Genomics for GRB7 Gene

Regulatory Elements for GRB7 Gene

Enhancers for GRB7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GRB7 on UCSC Golden Path with GeneCards custom track

Promoters for GRB7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GRB7 on UCSC Golden Path with GeneCards custom track

Genomic Location for GRB7 Gene

Chromosome:
17
Start:
39,737,909 bp from pter
End:
39,747,291 bp from pter
Size:
9,383 bases
Orientation:
Plus strand

Genomic View for GRB7 Gene

Genes around GRB7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRB7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRB7 Gene

Proteins for GRB7 Gene

  • Protein details for GRB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14451-GRB7_HUMAN
    Recommended name:
    Growth factor receptor-bound protein 7
    Protein Accession:
    Q14451
    Secondary Accessions:
    • B2RAV1
    • B3KNL0
    • B3KWP9
    • B7WP75
    • J3KQM4
    • Q53YD3
    • Q92568
    • Q96DF9
    • Q9Y220

    Protein attributes for GRB7 Gene

    Size:
    532 amino acids
    Molecular mass:
    59681 Da
    Quaternary structure:
    • Homodimer. Interacts (via SH2 domain) with EGFR, ERBB2, ERBB3 (when phosphorylated), ERBB4 (when phosphorylated), EPHB1, INSR, FGFR1, PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Interacts with SHC1. Interacts with RND1. Interacts (when tyrosine phosphorylated) with FHL2 and HAX1 (By similarity). Interacts (via SH2 domain) with RET and PTK2/FAK1. Interacts (when not phosphorylated) with ELAVL1. In stressed cells, but not in normal cells, part of a complex that contains at least GRB7, PTK2/FAK1, STAU1, ELAVL1 and TIA1. Interacts (via SH2 domain) with KIT (phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity).

    Three dimensional structures from OCA and Proteopedia for GRB7 Gene

    Alternative splice isoforms for GRB7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRB7 Gene

Proteomics data for GRB7 Gene at MOPED

Post-translational modifications for GRB7 Gene

  • Phosphorylated on serine and threonine residues in response to heregulin. Phosphorylated on tyrosine residues by TEK/TIE2. Phosphorylated on tyrosine residues in response to NTN1 signaling. Phosphorylation promotes stress granule disassembly during recovery after cellular stress (By similarity). Phosphorylated on tyrosine residues by PTK2/FAK1, and possibly also other kinases. Phosphorylation is enhanced by activation of receptor kinases. Tyrosine phosphorylation is essential for activation of down-stream protein kinases.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for GRB7 Gene

Domains & Families for GRB7 Gene

Protein Domains for GRB7 Gene

Suggested Antigen Peptide Sequences for GRB7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14451

UniProtKB/Swiss-Prot:

GRB7_HUMAN :
  • The PH domain mediates interaction with membranes containing phosphoinositides.
  • Belongs to the GRB7/10/14 family.
Domain:
  • The PH domain mediates interaction with membranes containing phosphoinositides.
  • Contains 1 PH domain.
  • Contains 1 Ras-associating domain.
  • Contains 1 SH2 domain.
Family:
  • Belongs to the GRB7/10/14 family.
genes like me logo Genes that share domains with GRB7: view

Function for GRB7 Gene

Molecular function for GRB7 Gene

GENATLAS Biochemistry:
growth factor receptor bound protein 7,homolog to a newly identified C elegans gene,coamplified with ERBB2 in primary gastric cancer,with two isoforms GRB7 and GRB7V,overexpressed in invasive esophageal carcinomas
UniProtKB/Swiss-Prot Function:
Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).

Gene Ontology (GO) - Molecular Function for GRB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035091 phosphatidylinositol binding IDA 12021278
genes like me logo Genes that share ontologies with GRB7: view
genes like me logo Genes that share phenotypes with GRB7: view

Animal Models for GRB7 Gene

MGI Knock Outs for GRB7:
  • Grb7 tm1b(EUCOMM)Wtsi

Animal Model Products

miRNA for GRB7 Gene

miRTarBase miRNAs that target GRB7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRB7 Gene

Localization for GRB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRB7 Gene

Cytoplasm. Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic granule. Cell projection. Note=Predominantly cytoplasmic. Detected in stress granules, where mRNA is stored under stress conditions. {ECO:0000250 UniProtKB:Q03160}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRB7 Gene COMPARTMENTS Subcellular localization image for GRB7 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GRB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with GRB7: view

Pathways & Interactions for GRB7 Gene

genes like me logo Genes that share pathways with GRB7: view

SIGNOR curated interactions for GRB7 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for GRB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017148 negative regulation of translation ISS --
GO:0030335 positive regulation of cell migration IDA 10893408
GO:0038128 ERBB2 signaling pathway TAS --
genes like me logo Genes that share ontologies with GRB7: view

Drugs & Compounds for GRB7 Gene

(2) Drugs for GRB7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for GRB7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GRB7: view

Transcripts for GRB7 Gene

Unigene Clusters for GRB7 Gene

Growth factor receptor-bound protein 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRB7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP4: - - - - - - - -
SP5: - -
SP6: - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - -
SP9: - -

ExUns: 16 ^ 17a · 17b · 17c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for GRB7 Gene

GeneLoc Exon Structure for
GRB7
ECgene alternative splicing isoforms for
GRB7

Expression for GRB7 Gene

mRNA expression in normal human tissues for GRB7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRB7 Gene

This gene is overexpressed in Esophagus - Mucosa (x7.0), Skin - Not Sun Exposed (Suprapubic) (x4.9), Skin - Sun Exposed (Lower leg) (x4.7), Kidney - Cortex (x4.6), and Pancreas (x4.1).

Protein differential expression in normal tissues from HIPED for GRB7 Gene

This gene is overexpressed in Lung (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GRB7 Gene



SOURCE GeneReport for Unigene cluster for GRB7 Gene Hs.86859

genes like me logo Genes that share expression patterns with GRB7: view

Protein tissue co-expression partners for GRB7 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GRB7 Gene

Orthologs for GRB7 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRB7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GRB7 35
  • 86.97 (n)
  • 88.72 (a)
GRB7 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRB7 35
  • 88.81 (n)
  • 93.77 (a)
GRB7 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grb7 35
  • 86.19 (n)
  • 90.96 (a)
Grb7 16
Grb7 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GRB7 35
  • 99.52 (n)
  • 99.82 (a)
GRB7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grb7 35
  • 85.94 (n)
  • 91.15 (a)
oppossum
(Monodelphis domestica)
Mammalia GRB7 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRB7 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRB7 35
  • 74.32 (n)
  • 73.17 (a)
GRB7 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRB7 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grb7 35
  • 67.76 (n)
  • 71.37 (a)
zebrafish
(Danio rerio)
Actinopterygii GRB7 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pico 36
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mig-10 36
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10684 36
  • 35 (a)
OneToMany
Species with no ortholog for GRB7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRB7 Gene

ENSEMBL:
Gene Tree for GRB7 (if available)
TreeFam:
Gene Tree for GRB7 (if available)

Paralogs for GRB7 Gene

Paralogs for GRB7 Gene

(2) SIMAP similar genes for GRB7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GRB7: view

Variants for GRB7 Gene

Sequence variations from dbSNP and Humsavar for GRB7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1131717 -- 39,744,906(+) AATGG(A/C)CACAA reference, synonymous-codon
rs1131721 -- 39,746,765(+) GAGGG(C/T)CGCCT reference, synonymous-codon, utr-variant-3-prime
rs2271307 -- 39,744,491(-) CCCCC(A/C/G)ACAAG intron-variant
rs2941518 -- 39,736,117(+) AGCCC(C/T)AGAGA upstream-variant-2KB
rs2941519 -- 39,747,478(-) ATGCC(C/T)GGCTC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for GRB7 Gene

Variant ID Type Subtype PubMed ID
nsv908207 CNV Loss 21882294
nsv2048 CNV Insertion 18451855
nsv908219 CNV Loss 21882294

Variation tolerance for GRB7 Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.59; 56.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GRB7 Gene

Disorders for GRB7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GRB7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
silver-russell syndrome
  • silver russell dwarfism
breast cancer
  • breast cancer, invasive ductal
esophageal cancer
  • esophageal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search GRB7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GRB7

Genetic Association Database (GAD)
GRB7
Human Genome Epidemiology (HuGE) Navigator
GRB7
Tumor Gene Database (TGDB):
GRB7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRB7
genes like me logo Genes that share disorders with GRB7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRB7 Gene

Publications for GRB7 Gene

  1. Association of Grb7 with phosphoinositides and its role in the regulation of cell migration. (PMID: 12021278) Shen T.L. … Guan J.L. (J. Biol. Chem. 2002) 3 4 23 67
  2. Growth factor receptor-bound protein-7 (Grb7) as a prognostic marker and therapeutic target in breast cancer. (PMID: 19717535) Nadler Y. … Kluger Y. (Ann. Oncol. 2010) 3 23
  3. The intertwining of structure and function: proposed helix-swapping of the SH2 domain of Grb7, a regulatory protein implicated in cancer progression and inflammation. (PMID: 20370637) Pias S. … Lyons B.A. (Crit. Rev. Immunol. 2010) 3 23
  4. Differential functions of growth factor receptor-bound protein 7 (GRB7) and its variant GRB7v in ovarian carcinogenesis. (PMID: 20388850) Wang Y. … Ngan H.Y. (Clin. Cancer Res. 2010) 3 23
  5. Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis. (PMID: 19473962) Chu P.Y. … Shen T.L. (J. Biol. Chem. 2009) 3 23

Products for GRB7 Gene

Sources for GRB7 Gene

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