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Aliases for GRB7 Gene

Aliases for GRB7 Gene

  • Growth Factor Receptor-Bound Protein 7 2 3
  • Epidermal Growth Factor Receptor GRB-7 3 4
  • GRB7 Adapter Protein 3 4
  • B47 3 4

External Ids for GRB7 Gene

Previous GeneCards Identifiers for GRB7 Gene

  • GC17M037569
  • GC17P039891
  • GC17P037804
  • GC17P038269
  • GC17P035147
  • GC17P037894
  • GC17P033688

Summaries for GRB7 Gene

Entrez Gene Summary for GRB7 Gene

  • The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for GRB7 Gene

GRB7 (Growth Factor Receptor-Bound Protein 7) is a Protein Coding gene. Among its related pathways are PI-3K cascade and Signaling by FGFR. GO annotations related to this gene include RNA binding and protein kinase binding. An important paralog of this gene is GRB14.

UniProtKB/Swiss-Prot for GRB7 Gene

  • Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).

Gene Wiki entry for GRB7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRB7 Gene

Genomics for GRB7 Gene

Regulatory Elements for GRB7 Gene

Genomic Location for GRB7 Gene

Start:
39,737,909 bp from pter
End:
39,747,291 bp from pter
Size:
9,383 bases
Orientation:
Plus strand

Genomic View for GRB7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRB7 Gene

Proteins for GRB7 Gene

  • Protein details for GRB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14451-GRB7_HUMAN
    Recommended name:
    Growth factor receptor-bound protein 7
    Protein Accession:
    Q14451
    Secondary Accessions:
    • B2RAV1
    • B3KNL0
    • B3KWP9
    • B7WP75
    • J3KQM4
    • Q53YD3
    • Q92568
    • Q96DF9
    • Q9Y220

    Protein attributes for GRB7 Gene

    Size:
    532 amino acids
    Molecular mass:
    59681 Da
    Quaternary structure:
    • Homodimer. Interacts (via SH2 domain) with EGFR, ERBB2, ERBB3 (when phosphorylated), ERBB4 (when phosphorylated), EPHB1, INSR, FGFR1, PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Interacts with SHC1. Interacts with RND1. Interacts (when tyrosine phosphorylated) with FHL2 and HAX1 (By similarity). Interacts (via SH2 domain) with RET and PTK2/FAK1. Interacts (when not phosphorylated) with ELAVL1. In stressed cells, but not in normal cells, part of a complex that contains at least GRB7, PTK2/FAK1, STAU1, ELAVL1 and TIA1. Interacts (via SH2 domain) with KIT (phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity).

    Three dimensional structures from OCA and Proteopedia for GRB7 Gene

    Alternative splice isoforms for GRB7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRB7 Gene

Proteomics data for GRB7 Gene at MOPED

Post-translational modifications for GRB7 Gene

  • Phosphorylated on serine and threonine residues in response to heregulin. Phosphorylated on tyrosine residues by TEK/TIE2. Phosphorylated on tyrosine residues in response to NTN1 signaling. Phosphorylation promotes stress granule disassembly during recovery after cellular stress (By similarity). Phosphorylated on tyrosine residues by PTK2/FAK1, and possibly also other kinases. Phosphorylation is enhanced by activation of receptor kinases. Tyrosine phosphorylation is essential for activation of down-stream protein kinases.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GRB7 Gene

Antibody Products

No data available for DME Specific Peptides for GRB7 Gene

Domains for GRB7 Gene

Gene Families for GRB7 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
  • SH2D :SH2 domain containing

Suggested Antigen Peptide Sequences for GRB7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14451

UniProtKB/Swiss-Prot:

GRB7_HUMAN :
  • Q14451
Domain:
  • The PH domain mediates interaction with membranes containing phosphoinositides.
  • Contains 1 PH domain.
  • Contains 1 Ras-associating domain.
  • Contains 1 SH2 domain.
Family:
  • Belongs to the GRB7/10/14 family.
genes like me logo Genes that share domains with GRB7: view

Function for GRB7 Gene

Molecular function for GRB7 Gene

GENATLAS Biochemistry:
growth factor receptor bound protein 7,homolog to a newly identified C elegans gene,coamplified with ERBB2 in primary gastric cancer,with two isoforms GRB7 and GRB7V,overexpressed in invasive esophageal carcinomas
UniProtKB/Swiss-Prot Function:
Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).

Gene Ontology (GO) - Molecular Function for GRB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005070 SH3/SH2 adaptor activity TAS 9710451
GO:0005515 protein binding IPI 10377264
GO:0019901 protein kinase binding IDA 12021278
GO:0035091 phosphatidylinositol binding IDA 12021278
genes like me logo Genes that share ontologies with GRB7: view
genes like me logo Genes that share phenotypes with GRB7: view

Animal Model Products

miRNA for GRB7 Gene

miRTarBase miRNAs that target GRB7

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GRB7 Gene

Localization for GRB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRB7 Gene

Cytoplasm. Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic granule. Cell projection. Note=Predominantly cytoplasmic. Detected in stress granules, where mRNA is stored under stress conditions (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRB7 Gene COMPARTMENTS Subcellular localization image for GRB7 gene
Compartment Confidence
cytosol 5
plasma membrane 5
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GRB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0005925 focal adhesion IDA 10893408
GO:0010494 cytoplasmic stress granule ISS --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with GRB7: view

Pathways for GRB7 Gene

genes like me logo Genes that share pathways with GRB7: view

PCR Array Products

Gene Ontology (GO) - Biological Process for GRB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007173 epidermal growth factor receptor signaling pathway TAS 9710451
GO:0007596 blood coagulation TAS --
GO:0009967 positive regulation of signal transduction TAS 9710451
GO:0017148 negative regulation of translation ISS --
genes like me logo Genes that share ontologies with GRB7: view

Compounds for GRB7 Gene

(4) Novoseek inferred chemical compound relationships for GRB7 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 64.4 28
phosphotyrosine 56.1 3
phosphatidylinositol 25.4 1
calcium 0 2
genes like me logo Genes that share compounds with GRB7: view

Transcripts for GRB7 Gene

Unigene Clusters for GRB7 Gene

Growth factor receptor-bound protein 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRB7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRB7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP4: - - - - - - - -
SP5: - -
SP6: - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - -
SP9: - -

ExUns: 16 ^ 17a · 17b · 17c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for GRB7 Gene

GeneLoc Exon Structure for
GRB7
ECgene alternative splicing isoforms for
GRB7

Expression for GRB7 Gene

mRNA expression in normal human tissues for GRB7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRB7 Gene

This gene is overexpressed in Esophagus - Mucosa (7.0), Skin - Not Sun Exposed (Suprapubic) (4.9), Skin - Sun Exposed (Lower leg) (4.7), Kidney - Cortex (4.6), and Pancreas (4.1).

Protein differential expression in normal tissues for GRB7 Gene

This gene is overexpressed in Lung (68.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GRB7 Gene

SOURCE GeneReport for Unigene cluster for GRB7 Gene Hs.86859

genes like me logo Genes that share expressions with GRB7: view

Expression partners for GRB7 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GRB7 Gene

Orthologs for GRB7 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRB7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GRB7 35
  • 86.97 (n)
  • 88.72 (a)
GRB7 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRB7 35
  • 88.81 (n)
  • 93.77 (a)
GRB7 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grb7 35
  • 86.19 (n)
  • 90.96 (a)
Grb7 16
Grb7 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GRB7 35
  • 99.52 (n)
  • 99.82 (a)
GRB7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grb7 35
  • 85.94 (n)
  • 91.15 (a)
oppossum
(Monodelphis domestica)
Mammalia GRB7 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRB7 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRB7 35
  • 74.32 (n)
  • 73.17 (a)
GRB7 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRB7 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grb7 35
  • 67.76 (n)
  • 71.37 (a)
zebrafish
(Danio rerio)
Actinopterygii GRB7 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pico 36
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mig-10 36
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10684 36
  • 35 (a)
OneToMany
Species with no ortholog for GRB7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRB7 Gene

ENSEMBL:
Gene Tree for GRB7 (if available)
TreeFam:
Gene Tree for GRB7 (if available)

Paralogs for GRB7 Gene

Paralogs for GRB7 Gene

Selected SIMAP similar genes for GRB7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GRB7: view

Variants for GRB7 Gene

Sequence variations from dbSNP and Humsavar for GRB7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1131717 -- 39,744,906(+) AATGG(A/C)CACAA synonymous-codon, reference
rs1131721 -- 39,746,765(+) GAGGG(C/T)CGCCT reference, synonymous-codon, utr-variant-3-prime
rs2271307 -- 39,744,491(-) CCCCC(A/C/G)ACAAG intron-variant
rs2313172 -- 39,738,837(+) TTTAG(A/T)GGATC intron-variant, utr-variant-5-prime, upstream-variant-2KB
rs2941518 -- 39,736,117(+) AGCCC(C/T)AGAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GRB7 Gene

Variant ID Type Subtype PubMed ID
nsv908207 CNV Loss 21882294
nsv2048 CNV Insertion 18451855
nsv908219 CNV Loss 21882294

Relevant External Links for GRB7 Gene

HapMap Linkage Disequilibrium report
GRB7

PCR Panel Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRB7 Gene

Disorders for GRB7 Gene

(2) University of Copenhagen DISEASES for GRB7 Gene

(10) Novoseek inferred disease relationships for GRB7 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 46 15
esophageal carcinoma 38.3 11
gastric cancer 32.4 3
cancer 30.1 8
tumors 14 14

Relevant External Links for GRB7

Genetic Association Database (GAD)
GRB7
Human Genome Epidemiology (HuGE) Navigator
GRB7
Tumor Gene Database (TGDB):
GRB7
genes like me logo Genes that share disorders with GRB7: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot and Genatlas for GRB7 Gene

Publications for GRB7 Gene

  1. Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma. (PMID: 8988034) Tanaka S. … Sugimachi K. (Cancer Res. 1997) 3 4 23
  2. Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer. (PMID: 9125150) Kishi T. … Terada M. (Biochem. Biophys. Res. Commun. 1997) 3 4 23
  3. Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3. (PMID: 9516479) Fiddes R.J. … Daly R.J. (J. Biol. Chem. 1998) 3 4 23
  4. A novel variant of human Grb7 is associated with invasive esophageal carcinoma. (PMID: 9710451) Tanaka S. … Sugimachi K. (J. Clin. Invest. 1998) 3 4 23
  5. Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family. (PMID: 10664463) Vayssiere B. … Camonis J. (FEBS Lett. 2000) 3 4 23

Products for GRB7 Gene

Sources for GRB7 Gene

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