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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GRB7 Gene

protein-coding   GIFtS: 65
GCID: GC17P037894

Growth Factor Receptor-Bound Protein 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Growth Factor Receptor-Bound Protein 71 2
Epidermal Growth Factor Receptor GRB-72 3
B472 3
GRB7 Adapter Protein2 3

External Ids:    HGNC: 45671   Entrez Gene: 28862   Ensembl: ENSG000001417387   OMIM: 6015225   UniProtKB: Q144513   

Export aliases for GRB7 gene to outside databases

Previous GC identifers: GC17M037569 GC17P039891 GC17P037804 GC17P038269 GC17P035147 GC17P033688


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GRB7 Gene:
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of
receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein
that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the
integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript
variants encoding two different isoforms have been found for this gene. (provided by RefSeq, Jun 2011)

GeneCards Summary for GRB7 Gene: 
GRB7 (growth factor receptor-bound protein 7) is a protein-coding gene. Diseases associated with GRB7 include silver-russell syndrome, and eosinophilia, and among its related super-pathways are Development Angiopoietin - Tie2 signaling and Cell adhesion Ephrins signaling. GO annotations related to this gene include protein kinase binding and RNA binding. An important paralog of this gene is APBB1IP.

UniProtKB/Swiss-Prot: GRB7_HUMAN, Q14451
Function: Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates
down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or
MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the
regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress
granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not
phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after
cellular stress (By similarity)

Gene Wiki entry for GRB7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GRB7 gene promoter:
         E2F-4   E2F-3a   E2F-1   E2F   ZIC2/Zic2   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GRB7 promoter sequence
   Search SABiosciences Chromatin IP Primers for GRB7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRB7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

GRB7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRB7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P037894:  view genomic region     (about GC identifiers)

Start:
37,894,162 bp from pter      End:
37,903,544 bp from pter
Size:
9,383 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GRB7_HUMAN, Q14451 (See protein sequence)
Recommended Name: Growth factor receptor-bound protein 7  
Size: 532 amino acids; 59681 Da
Subunit: Homodimer. Interacts (via SH2 domain) with EGFR, ERBB2, ERBB3 (when phosphorylated), ERBB4 (when
phosphorylated), EPHB1, INSR, FGFR1, PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated).
Interacts with SHC1. Interacts with RND1. Interacts (when tyrosine phosphorylated) with FHL2 and HAX1 (By
similarity). Interacts (via SH2 domain) with RET and PTK2/FAK1. Interacts (when not phosphorylated) with ELAVL1.
In stressed cells, but not in normal cells, part of a complex that contains at least GRB7, PTK2/FAK1, STAU1,
ELAVL1 and TIA1. Interacts (via SH2 domain) with KIT (phosphorylated). Interacts (via SH2 domain) with TEK/TIE2
(tyrosine phosphorylated) (By similarity)
Subcellular location: Cytoplasm. Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein;
Cytoplasmic side. Cytoplasmic granule (By similarity). Cell projection. Note=Predominantly cytoplasmic. Detected
in stress granules, where mRNA is stored under stress conditions (By similarity)
5 PDB 3D structures from and Proteopedia for GRB7:
1MW4 (3D)        1WGR (3D)        2L4K (3D)        2QMS (3D)        3PQZ (3D)    
Secondary accessions: B2RAV1 B3KNL0 B3KWP9 B7WP75 J3KQM4 Q53YD3 Q92568 Q96DF9 Q9Y220
Alternative splicing: 4 isoforms:  Q14451-1   Q14451-2   Q14451-3   Q14451-4   (Ref.5 (BAG54211) sequence is in conflict in position: 20:C->R)

Explore the universe of human proteins at neXtProt for GRB7: NX_Q14451

Explore proteomics data for GRB7 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on serine and threonine residues in response to heregulin. Phosphorylated on tyrosine residues by
    TEK/TIE2. Phosphorylated on tyrosine residues in response to NTN1 signaling. Phosphorylation promotes stress
    granule disassembly during recovery after cellular stress (By similarity). Phosphorylated on tyrosine residues by
    PTK2/FAK1, and possibly also other kinases. Phosphorylation is enhanced by activation of receptor kinases.
    Tyrosine phosphorylation is essential for activation of down-stream protein kinases
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14451

  • GRB7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GRB7 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001025173.1  NP_001229371.1  NP_001229372.1  NP_005301.2  

    ENSEMBL proteins: 
     ENSP00000463416   ENSP00000310771   ENSP00000463126   ENSP00000377761   ENSP00000403459  
     ENSP00000377759   ENSP00000377754   ENSP00000311752  
    Reactome Protein details: Q14451
    Human Recombinant Protein Products for GRB7: 
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    Novus Biologicals GRB7 Proteins
    Novus Biologicals GRB7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0005925focal adhesion IDA10893408
    GO:0010494cytoplasmic stress granule ISS--
    GO:0042995cell projection IEA--

    GRB7 for ontologies           About GeneDecksing



    GRB7 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing
    SH2D: SH2 domain containing

    5 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR000159 Ras-assoc
     IPR015042 BPS-dom
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q14451

    ProtoNet protein and cluster: Q14451

    3 Blocks protein domains:
    IPB000159 RA domain
    IPB000980 SH2 domain signature
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: GRB7_HUMAN, Q14451
    Domain: The PH domain mediates interaction with membranes containing phosphoinositides
    Similarity: Belongs to the GRB7/10/14 family
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Ras-associating domain
    Similarity: Contains 1 SH2 domain


    GRB7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRB7_HUMAN, Q14451
    Function: Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates
    down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or
    MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the
    regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress
    granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not
    phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after
    cellular stress (By similarity)

         Genatlas biochemistry entry for GRB7:
    growth factor receptor bound protein 7,homolog to a newly identified C elegans gene,coamplified with ERBB2 in
    primary gastric cancer,with two isoforms GRB7 and GRB7V,overexpressed in invasive esophageal carcinomas

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005070SH3/SH2 adaptor activity TAS9710451
    GO:0005515protein binding IPI10664463
    GO:0005543phospholipid binding ----
    GO:0019901protein kinase binding IDA12021278
         
    GRB7 for ontologies           About GeneDecksing


    Phenotypes:
         8 GenomeRNAi human phenotypes for GRB7:
     Decreased Salmonella enterica   Decreased focal adhesion (FA)   Decreased viability of wild-ty  Downregulation of NF-kappaB pa 
     Downregulation of NF-kappaB pa  Increased Salmonella enterica   Increased Salmonella enterica   Increased cell number in G1, a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GRB7 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRB7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GRB7 

    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate GRB7 (see all 14):
    hsa-miR-3163 hsa-miR-193a-3p hsa-miR-520d-5p hsa-miR-324-3p hsa-miR-3922-3p hsa-miR-2116* hsa-miR-629* hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidGRB7 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRB7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GRB7 About   (see all 20)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development PDGF signaling via STATs and NF-kB
    Development Angiopoietin - Tie2 signaling0.38
    Angiopoietin receptor Tie2-mediated signaling0.32
    Angiopoietin-TIE2 Signaling0.36
    2Cell adhesion Ephrins signaling
    Cell adhesion Ephrins signaling0.30
    EPHB forward signaling0.30
    3Signaling by FGFR
    Signaling by ERBB20.90
    Signaling by PDGF0.85
    Downstream signal transduction0.90
    4Neurophysiological process Receptor-mediated axon growth repulsion
    Neurophysiological process Receptor-mediated axon growth repulsion0.94
    5PIP3 activates AKT signaling
    Signaling by SCF-KIT0.72

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for GRB7
        Development Angiopoietin - Tie2 signaling
    Neurophysiological process Receptor-mediated axon growth repulsion
    Development ERBB-family signaling
    Cell adhesion Ephrins signaling

    1 R&D Systems Pathway for GRB7
        Akt Signaling Pathway

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GRB7
        Breast Cancer Regulation by Stathmin1
    Caspase Cascade
    Integrin Pathway
    Angiopoietin-TIE2 Signaling

    4 GeneGo (Thomson Reuters) Pathways for GRB7
        Development ERBB-family signaling
    Neurophysiological process Receptor-mediated axon growth repulsion
    Development Angiopoietin - Tie2 signaling
    Cell adhesion Ephrins signaling

    5/7 BioSystems Pathways for GRB7 (see all 7)
        EGFR1 Signaling Pathway
    Kit Receptor Signaling Pathway
    EPHB forward signaling
    PDGFR-beta signaling pathway
    Angiopoietin receptor Tie2-mediated signaling

    5/9        Reactome Pathways for GRB7 (see all 9)
        Hemostasis
    GRB7 events in ERBB2 signaling
    Tie2 Signaling
    Signaling by ERBB2
    Downstream signal transduction



    GRB7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRB7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/166 Interacting proteins for GRB7 (Q144511, 2, 3 ENSP000003107714) via UniProtKB, MINT, STRING, and/or I2D (see all 166)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000243003Q5SQ642, 3, ENSP000004075354MINT-8032089 MINT-8032104 I2D: score=3 STRING: ENSP00000407535
    LY6G6FQ5SQ642, 3, ENSP000003649924MINT-8032089 MINT-8032104 I2D: score=3 STRING: ENSP00000364992
    EPHB1P547621, 2, 3, ENSP000003810974EBI-970191,EBI-80252 MINT-8025824 MINT-8025809 I2D: score=2 STRING: ENSP00000381097
    ENSG00000239741Q5SQ642, 3MINT-8032089 MINT-8032104 I2D: score=3 
    ENSG00000240008Q5SQ642, 3MINT-8032089 MINT-8032104 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007173epidermal growth factor receptor signaling pathway TAS9710451
    GO:0007596blood coagulation TAS--
    GO:0017148negative regulation of translation ISS--
    GO:0030335positive regulation of cell migration IDA10893408

    GRB7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GRB7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GRB7

    4 Novoseek inferred chemical compound relationships for GRB7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 64.4 30 10803466 (4), 7907978 (3), 19473962 (3), 8988034 (2) (see all 19)
    phosphotyrosine 56.1 3 10803466 (1), 9516479 (1), 11451957 (1)
    phosphatidylinositol 25.4 1 11418135 (1)
    calcium 0 2 15806159 (1), 16475676 (1)

    Search CenterWatch for drugs/clinical trials and news about GRB7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GRB7 gene (4 alternative transcripts): 
    NM_001030002.2  NM_001242442.1  NM_001242443.1  NM_005310.3  

    Unigene Cluster for GRB7:

    Growth factor receptor-bound protein 7
    Hs.86859  [show with all ESTs]
    Unigene Representative Sequence: NM_005310
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000577695 ENST00000309156(uc002hsr.3) ENST00000485182 ENST00000583813
    ENST00000584853 ENST00000584819 ENST00000394211(uc002hss.3 uc010cwc.3 uc002hst.3)
    ENST00000578702 ENST00000445327(uc021twu.1) ENST00000394209 ENST00000584053
    ENST00000394204 ENST00000461756 ENST00000473071 ENST00000309185
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    Additional mRNA sequence: 

    AB008789.1 AB008790.1 AK027729.1 AK125544.1 AK222849.1 AK222870.1 AK290115.1 AK294620.1 
    AK314368.1 BC006535.2 BT006686.1 D43772.1 D87513.1 

    17 DOTS entries:

    DT.91709524  DT.443684  DT.101979715  DT.91709508  DT.100782152  DT.91709526  DT.75124027  DT.100782153 
    DT.91710427  DT.100698855  DT.120994235  DT.40131534  DT.91657796  DT.92023413  DT.92038597  DT.95073517 
    DT.95073520 

    24/125 AceView cDNA sequences (see all 125):

    CR590154 AA742704 CK823562 AI336922 BM983555 BI822688 AI885468 BQ647872 
    CA841250 BC006535 CA840989 BQ777571 AK027729 BX094412 AW291929 BQ777870 
    AA053738 CB989402 AW615410 AK125544 BM918936 BE062115 H53703 BF747278 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for GRB7 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
    SP1:              -     -     -     -     -                                   -                                                                                 
    SP2:                          -     -     -                                   -                                                                                 
    SP3:                                      -                                   -                                                                                 
    SP4:              -     -     -     -     -                 -     -           -                                                                                 
    SP5:                                                                          -                                                                             -   

    ExUns: 16 ^ 17a · 17b · 17c
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for GRB7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GRB7 expression in normal human tissues (normalized intensities)      GRB7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCAGCCCG
    GRB7 Expression
    About this image


    GRB7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 4 entries
             Ureter
             visceral organ   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             visceral organ/lung/right lung   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             201B7
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal

    See GRB7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GRB7

    SOURCE GeneReport for Unigene cluster: Hs.86859
        SABiosciences Expression via Pathway-Focused PCR Arrays including GRB7: 
              Breast Cancer in human mouse rat
              Embryonic Stem Cells in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GRB7 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grb71 , 5 growth factor receptor bound protein 71, 5 86.19(n)1
    90.96(a)1
      11 (61.75 cM)5
    147861  NM_010346.21  NP_034476.11 
     984463945 
    chicken
    (Gallus gallus)
    Aves GRB71 growth factor receptor-bound protein 7 74.07(n)
    72.93(a)
      426597  XM_424234.3  XP_424234.3 
    lizard
    (Anolis carolinensis)
    Reptilia GRB76
    Uncharacterized protein
    62(a)
    1 ↔ 1
    6(68478056-68510051)
    zebrafish
    (Danio rerio)
    Actinopterygii GRB76
    growth factor receptor-bound protein 7
    47(a)
    1 ↔ 1
    24(37911841-37939602)
    fruit fly
    (Drosophila melanogaster)
    Insecta pico6
    pico
    8(a)
    1 → many
    X(19724248-19746092)
    worm
    (Caenorhabditis elegans)
    Secernentea mig-106
    Abnormal cell migration protein 10
    11(a)
    1 → many
    III(8279108-8305832)


    ENSEMBL Gene Tree for GRB7 (if available)
    TreeFam Gene Tree for GRB7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GRB7 gene
    APBB1IP2  RAPH12  GRB102  GRB142  
    2 SIMAP similar genes for GRB7 using alignment to 3 protein entries:     GRB7_HUMAN (see all proteins):
    GRB10    GRB14

    GRB7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/345 SNPs in GRB7 are shown (see all 345)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1512073721,2
    --33697840(+) CACATA/GGTAGG 4 -- ds50010--------
    rs777446611,2
    C--37896894(+) TCAGG-/CCCCAC 4 -- int10--------
    rs351010341,2
    C--37900073(+) AAAAA-/AAAAAA 4 -- int11Minor allele frequency- A:0.00NA 2
    rs3765330111,2
    C--37902694(+) GGGAG-/CCCCAT 4 -- int10--------
    rs113321371,2
    C,F--37903881(+) TCTGGA/-AAAAA 4 -- ds50012Minor allele frequency- -:0.50NA 4
    rs801738091,2
    C--37903881(+) TCTGGA/GAAAAA 4 -- ds50010--------
    rs29415181,2
    C,F,H--38679576(+) AGCCCC/TAGAGA 1 -- us2k120Minor allele frequency- T:0.02NS EA NA WA CSA 1468
    rs1123375811,2
    C,F--38679769(+) GCTGCG/ATCTCC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs664595481,2
    C,F--38679903(+) TCCACT/AGAGAA 2 -- us2k18Minor allele frequency- A:0.30NA WA CSA 131
    rs1464559481,2
    --38679927(+) CCCTAA/TGTGAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for GRB7 (37894162 - 37903544 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for GRB7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2048CNV Insertion18451855
    nsv908219CNV Loss21882294
    nsv908207CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    Oncogenes & Tumor Suppressor Genes 384HC
    WNT Signaling
    SeqTarget long-range PCR primers for resequencing GRB7
    DNA2.0 Custom Variant and Variant Library Synthesis for GRB7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601522    OMIM disorders: --

    15 diseases for GRB7:    About MalaCards
    silver-russell syndrome    eosinophilia    germ cell tumors    gastric cancer
    esophagitis    atopic dermatitis    pancreatic cancer    chronic lymphocytic leukemia
    dermatitis    pancreatitis    breast cancer    adenocarcinoma
    hepatocellular carcinoma    leukemia    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for GRB7:
    Breast cancer     Silver-Russell syndrome

    GRB7 for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for GRB7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 46 20 19717535 (4), 7907978 (2), 8940081 (2), 12551896 (1) (see all 10)
    esophageal carcinoma 38.3 12 10797316 (6), 9710451 (3), 8988034 (2)
    gastric cancer 32.4 3 9125150 (1), 14585167 (1), 12739007 (1)
    cancer 30.1 13 11956097 (1), 9794242 (1), 20388850 (1), 17894853 (1) (see all 8)
    tumors 14 22 15386389 (5), 7907978 (1), 20388850 (1), 12941816 (1) (see all 10)
    metastasis 7.38 10 16595785 (3), 15930003 (1), 10797316 (1), 17634422 (1) (see all 6)
    pancreatic cancer 6.76 3 16595785 (3)
    breast carcinoma 3.23 1 8988034 (1)
    adenocarcinoma 0 1 15386389 (1)
    carcinoma 0 8 15386389 (6), 19473962 (1)

    Genetic Association Database (GAD): GRB7
    Human Genome Epidemiology (HuGE) Navigator: GRB7 (2 documents)
    Tumor Gene Database (TGDB): GRB7

    Export disorders for GRB7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GRB7 gene, integrated from 9 sources (see all 112):
    (articles sorted by number of sources associating them with GRB7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of Grb7 with phosphoinositides and its role in the regulation of cell migration. (PubMed id 12021278)1, 2, 9 Shen T.L....Guan J.L. (2002)
    2. Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration. (PubMed id 10893408)1, 2, 9 Han D.C....Guan J.L. (2000)
    3. Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3. (PubMed id 9516479)1, 2, 9 Fiddes R.J....Daly R.J. (1998)
    4. Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma. (PubMed id 8988034)1, 2, 9 Tanaka S....Sugimachi K. (1997)
    5. Tyrosine phosphorylation of growth factor receptor-bo und protein-7 by focal adhesion kinase in the regulation of cell migration, pro liferation, and tumorigenesis. (PubMed id 19473962)1, 2, 9 Chu P.Y....Shen T.L. (2009)
    6. Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2. (PubMed id 10803466)1, 2, 9 Kasus-Jacobi A....Burnol A.F. (2000)
    7. Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family. (PubMed id 10664463)1, 2, 9 Vayssiere B.... Camonis J. (2000)
    8. A novel variant of human Grb7 is associated with invasive esophageal carcinoma. (PubMed id 9710451)1, 2, 9 Tanaka S....Sugimachi K. (1998)
    9. Grb7-SH2 domain dimerisation is affected by a single point mutation. (PubMed id 15841400)1, 2, 9 Porter C.J....Wilce J.A. (2005)
    10. Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer. (PubMed id 9125150)1, 2, 9 Kishi T.... Terada M. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2886 HGNC: 4567 AceView: GRB7 Ensembl:ENSG00000141738 euGenes: HUgn2886
    ECgene: GRB7 H-InvDB: GRB7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GRB7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GRB7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GRB7 gene:
    Search GeneIP for patents involving GRB7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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