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GRB2 Gene

protein-coding GIFtS: 71

GC17M070825

growth factor receptor-bound protein 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ASH ^², ³
EGFRBP-GRB2 ^²
Grb3-3 ^²
HT027 ^²
MST084 ^²
MSTP084 ^²
OTTHUMP00000166096 ^²
OTTHUMP00000166097 ^²
OTTHUMP00000166098 ^²

Descriptions
Adapter protein GRB2 ^³
Protein Ash ^³
SH2/SH3 adapter GRB2 ^³
abundant SRC homology ^²
epidermal growth factor receptor-binding protein GRB2 ^²
growth factor receptor-bound protein 2 ^²
growth factor receptor-bound protein 3 ^²

External Ids
HGNC: 4566¹
Entrez Gene: 2885²
UniProtKB: P62993³
Ensembl: ENSG00000177885⁷

Search outside databases for aliases for GRB2 gene

Previous GC identifers: GC17M073313 GC17M076374 GC17M073779 GC17M073911

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GRB2:

The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2

domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions

of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is

similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two

alternatively spliced transcript variants encoding different isoforms have been found for this

gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: GRB2_HUMAN, P62993

Function: Isoform GRB3-3 does not bind to phosphorylated epidermal growth factor receptor (EGFR)

but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform GRB3-3 acts as a

dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active

programmed cell death

Gene Wiki entry for GRB2 (Grb2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GRB2 gene

Entrez Gene cytogenetic band: 17q24-q25 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q24-q25

GRB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M070825: (about GC identifiers)

Start:	70,825,752 bp from pter
End:	70,913,385 bp from pter
Size:	87,634 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010641.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: GRB2_HUMAN, P62993 (See protein sequence)

Recommended Name: Growth factor receptor-bound protein 2

Size: 217 amino acids; 25206 Da

Subunit: Associates with activated Tyr-phosphorylated EGF receptors and PDGF receptors via its SH2

domain. Also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, IRS4,

SHC and LNK; probably via the concerted action of both its SH2 and SH3 domains. It also seems to

interact with RAS in the signaling pathway leading to DNA synthesis. Binds to and translocates the

guanine nucleotide exchange factors SOS. Interacts with phosphorylated TOM1L1 and MET. Interacts

with the phosphorylated C-terminus of SH2B2. Interacts with phosphorylated SIT1, LAX1, LAT, LAT2

and LIME1 upon TCR and/or BCR activation. Interacts with NISCH, PTPNS1, REPS2 and the syntrophin

SNTA1. Interacts with REPS1 and PIK3C2B via its SH3 domains (By similarity). Interacts with HCV

NS5A via its SH3 domains. Interacts with CBL and CBLB. Interacts with JUB and CLNK (By

similarity). Interacts with SHB, INPP5D/SHIP1, SKAP1 and SKAP2. Forms a complex with MUC1 and

SOS1, through interaction of the SH3 domains with SOS1 and the SH2 domain with phosphorylated

MUC1. Interacts with PRNP (By similarity). Interacts with RALGPS1 and with HCST. Interacts (via

SH3 domain) with HEV ORF3 protein. Interacts with GAPT

Subcellular location: Golgi apparatus (By similarity)

PDB structures from and Proteopedia :

1AZE (3D)

1BM2 (3D)

1BMB (3D)

1CJ1 (3D)

1FHS (3D)

1FYR (3D)

1GCQ (3D)

1GFC (3D)

1GFD (3D)

1GHU (3D)

1GRI (3D)

1IO6 (3D)

1JYQ (3D)

1JYR (3D)

1JYU (3D)

1QG1 (3D)

1TZE (3D)

1X0N (3D)

1ZFP (3D)

2AOA (3D)

2AOB (3D)

2H46 (3D)

2H5K (3D)

2HUW (3D)

3C7I (3D)

Secondary accessions: P29354 Q14450 Q63057 Q63059

Alternative splicing: 2 isoforms: P62993-1, P29354-1 P62993-2, P29354-2 (Additional isoforms seem to exist)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_002077.1 NP_987102.1

ENSEMBL proteins:

ENSP00000317360 ENSP00000339007 ENSP00000376345 ENSP00000376347 ENSP00000376346

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant GRB2 Protein
	Sigma-Aldrich Proteins for GRB2
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GRB2)
	Human Recombinant Proteins from Abnova (GRB2)

OriGene Purified Recombinant Human Protein: GRB2

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005794	Golgi apparatus	IEA	--
GO:0005829	cytosol	TAS	14722116

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Antibodies for GRB2:

	Invitrogen Antibodies for GRB2
	Millipore Mono- and Polyclonal Antibodies for the study of GRB2
	Sigma-Aldrich Antibody Arrays and Antibodies for GRB2
	R&D Systems Antibodies for GRB2
	Cell Signaling Technology (CST) Antibodies for GRB2
	Antibodies from Abcam (GRB2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GRB2)
	Novus Biologicals Antibodies for GRB2

Assays for GRB2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P62993

ProtoNet protein and cluster: P62993

UniProtKB/Swiss-Prot: GRB2_HUMAN, P62993

Domain: The SH3 domains mediate interaction with RALGPS1 and SHB

Similarity: Belongs to the GRB2/sem-5/DRK family

Similarity: Contains 1 SH2 domain

Similarity: Contains 2 SH3 domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GRB2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GRB2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002086

Applied Biosystems Silencer® siRNAs for GRB2

Sigma-Aldrich siRNA for GRB2

Sigma-Aldrich shRNA Panels and shRNA for GRB2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GRB2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002086
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002086
untagged cDNA clones in CMV expression vector (see all 2): NM_002086

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002086

UniProtKB/Swiss-Prot: GRB2_HUMAN, P62993

Function: Adapter protein that provides a critical link between cell surface growth factor

receptors and the Ras signaling pathway

Function: Isoform GRB3-3 does not bind to phosphorylated epidermal growth factor receptor (EGFR)

but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform GRB3-3 acts as a

dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active

programmed cell death

Genatlas biochemistry entry for GRB2:

growth factor receptor bound protein 2,major CBL associated protein,homolog to Caenorhabditis

elegans Sem5 gene and Drosophila Drk,STAR playing a key role in insulin signal transduction

through connecting with IRS1 and IGFR5,and in mitogenic RAS signalic through interaction with SHC1

13 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Grb2):

	craniofacial	digestive/alimentary	embryogenesis	growth/size
hearing/vestibular/ear	homeostasis/metabolism	immune system	lethality-prenatal/perinatal	nervous system
normal	skeleton	tumorigenesis

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005070	SH3/SH2 adaptor activity	TAS	8253073
GO:0005154	epidermal growth factor receptor binding	IPI	12577067
GO:0043560	insulin receptor substrate binding	IPI	8388384

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/69 Sigma-Aldrich "Your Favorite Gene" Pathways for GRB2 (Your Favorite Gene powered by Ingenuity) (see all 69 )

VEGF Signaling
ERK/MAPK Signaling
FGF Signaling
Role of NFAT in Regulation of the Immune Response
14-3-3-mediated Signaling

GeneDecks GRB2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for GRB2

5/529 Interacting proteins for GRB2 (P62993^{1, 2} ENSP00000339007³) via UniProtKB, MINT, and/or STRING (see all 529 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CBL	P22681², ENSP00000264033³	MINT-65972 MINT-7040249 MINT-60974 MINT-65979 MINT-6539462 MINT-6169721 MINT-60977 MINT-65973 STRING (score=.999)
SHC1	P29353², ENSP00000357432³	MINT-60983 MINT-6169992 MINT-1782399 MINT-49658 MINT-60982 MINT-61537 STRING (score=.999)
ERBB4	Q15303², ENSP00000342235³	MINT-61531 MINT-61528 MINT-61534 MINT-61527 MINT-61530 MINT-61532 STRING (score=.984)
MAP2	P11137², ENSP00000353508³	MINT-50654 MINT-50655 MINT-50657 MINT-50658 MINT-50656 STRING (score=.992)
PTPN1	P18031², ENSP00000360683³	MINT-6762852 MINT-6794792 MINT-6762842 MINT-6794785 STRING (score=.999)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007173	epidermal growth factor receptor signaling pathway	TAS	1322798
GO:0007265	Ras protein signal transduction	TAS	8253073
GO:0007267	cell-cell signaling	TAS	8253073
GO:0008286	insulin receptor signaling pathway	IPI	8388384
GO:0044419	interspecies interaction between organisms	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for GRB2

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GRB2
10/29 Novoseek chemical compound relationships for GRB2 gene (see all 29 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	89.74	620	8910422 (5), 8388384 (5), 8491186 (4), 11726515 (4) (see all 99)
phosphotyrosine	84.84	50	10356320 (2), 8391166 (1), 9183666 (1), 11689444 (1) (see all 34)
phosphatidylinositol	80.55	91	7961682 (3), 7791764 (3), 7692230 (2), 9565634 (2) (see all 72)
pp36	79.75	5	9541596 (2), 9529333 (2), 7544353 (1)
phosphoinositide	48.06	13	10330169 (1), 12220227 (1), 15579470 (1), 8894489 (1) (see all 11)
wortmannin	46.72	1	16267404 (1)
phosphatidylinositol-3,4,5-trisphosphate	46.65	2	17923698 (1)
phenylalanine	44.78	9	11002419 (1), 16407827 (1), 7559570 (1), 8959326 (1) (see all 9)
gp 130	42.80	2	9013873 (1), 8934572 (1)
threonine	42.29	4	9346925 (1), 9346957 (1), 9322943 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GRB2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GRB2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002086

Sigma-Aldrich siRNA for GRB2

Sigma-Aldrich shRNA Panels and shRNA for GRB2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002086 NM_203506

REFSEQ mRNAs for GRB2 gene (2 alternative transcripts):

NM_002086.4 NM_203506.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002086 NM_203506

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002086
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002086
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002086

Additional cDNA sequence:

AF171699.1 AF246238.1 AF302079.1 AF498925.1 AK024539.1 AK091010.1 AK315565.1 BC000631.2

BC019082.2 BC033644.1 BC039827.1 BC043007.1 CR450363.1 CR541942.1 L29511.1 M96995.1

X62852.1

24 DOTS entries:

DT.91786336 DT.101985106 DT.95197797 DT.455862 DT.100833847 DT.100827631 DT.97788620 DT.91768193

DT.100827630 DT.121008073 DT.121008099 DT.95197812 DT.100039623 DT.121008094 DT.100827635 DT.100827636

DT.65285546 DT.100827634 DT.121008122 DT.121008141 DT.91710775 DT.95177922 DT.97778180 DT.92454820

24/631 AceView cDNA sequences (see all 631 ):

BQ880390 BQ065151 BU608476 BU619642 AI572432 CA411871 BU838801 BI861103

AU133060 BU195750 BC000631 BG222582 AI097514 BU678646 BF435763 BM968429

AL134982 AI073688 CB160609 CB159959 BM450260 AW073331 BG058655 BM708461

highest scoring ESTs for GRB2:

AA313802 AI439688 AI815684 AL134982 AU142798 AW161184 AW674664 BC000631 BE387478 BE396668

Unigene Cluster for GRB2:

Growth factor receptor-bound protein 2

Hs.444356 [show with all ESTs]

Unigene Representative Sequence: NM_002086

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GRB2 (see all 7 )

ExUns:	1	^	2	^	3a	·	3b	·	3c	·	3d	·	3e	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	·	8c	·	8d
SP1:			-		-		-						-		-
SP2:													-		-
SP3:													-		-								-
SP4:													-		-						-
SP5:			-		-		-						-

About this scheme

ECgene alternative splicing isoforms for GRB2

5 Ensembl transcripts including schematic representations:

ENST00000316615 ENST00000316804 ENST00000392562 ENST00000392564 ENST00000392563

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GRB2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GRB2

¹ / ² / ³

7 probe-sets matching GRB2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33855_at²^{, 3}	U95-A	1	1.00	1.00	0.66	0.84	M96995	0.80	1.00	0.91	1
46217_at²^{, 3}	U95-B	1	1.00	1.00	0.85	1.35	AI439688	0.80	1.00	0.91	1
1565_s_at²^{, 3}	U95-A	1	1.00	1.00	0.48	0.82	M96995	0.80	1.00	0.91	1
223049_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF246238	0.60	1.00	0.82	1
215075_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	L29511	0.60	1.00	0.82	1
223049_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215075_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks GRB2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAGCCTTGCT

SOURCE GeneReport for Unigene cluster: Hs.444356
Expression variation in blood from EXPOLDB for GRB2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GRB2 gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GRB2¹	--	growth factor receptor-bound protein 2	94.78(n) 100(a)	483312 XM_540431.2 XP_540431.2
chimpanzee (Pan troglodytes)	GRB2¹	--	growth factor receptor-bound protein 2	100(n) 100(a)	737245 XM_001141640.1 XP_001141640.1
cow (Bos taurus)	GRB2¹	--	growth factor receptor-bound protein 2	93.86(n) 100(a)	535298 NM_001034630.1 NP_001029802.1
rat (Rattus norvegicus)	Grb2¹	--	growth factor receptor bound protein 2	92.01(n) 100(a)	81504 NM_030846.2 NP_110473.2
mouse (Mus musculus)	Grb2^{1, 5}	11 (75.00 cM)⁵	growth factor receptor bound protein 2^{1, 5}	92.17(n)¹ 99.54(a)¹	14784¹ NM_008163.3¹ NP_032189.1¹ AA408164⁵ AI323718⁵ (see all 28)

About this table Species with no ortholog for GRB2

ENSEMBL Gene Tree for GRB2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GRB2 gene

GRAP2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/682 NCBI SNPs in GRB2 are shown (see all 682 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 118)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7219^1,2	A,C,F,H	70826963(-)	`TAAAGA/GCAGTC`	2	--	ut3¹ ese³		5		MN EU EA WA	602
	rs17490675^1,2	F,H	70825380(+)	`TTCTTG/CTTTAA`	2	--	ng5¹		8		NA EU EA WA	1956
	rs3211129^1,2	H	70826201(-)	`CCCAAA/CCCCCT`	2	--	ut3¹ ese³		5		MN EU EA WA	580
--	rs9890256^1,2	C	70914709(+)	`CttttG/Tttttt`	2	--	ng3¹		0	--	--	--	--
--	rs11290288^1,2	C	70826873(+)	`TGCTT-/TGTCTC`	2	--	ut3¹		0	--	--	--	--
	rs34536280^1,2	F	70833636(+)	`CCATCG/ATGCCG`	2	H/H	syn¹ int¹		1		NA	70
	rs2053156^1,2	A,C,F,H,O	70890035(+)	`ACTATT/GTTACT`	2	--	int¹		7		EU EA WA NA	554
	rs1076094^1,2	A,C,F,H,O	70856306(+)	`GGAAAC/TTGCTG`	2	--	int¹		22		NA EA EU WA	2007
	rs4789172^1,2	A,C,F,H	70853307(+)	`CAAATC/TGGGAA`	2	--	int¹		13		EA NA EU WA	2456
	rs4788890^1,2	A,C,F,H	70901041(+)	`ACATCG/ACACCA`	2	--	int¹		4		EU EA WA	414

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HapMap Linkage Disequilibrium images for GRB2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 108355

10/30 Novoseek disease relationships for GRB2 gene (see all 30 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia chronic	39.30	1	15143164 (1)
wiskott-aldrich syndrome	38.59	3	9307968 (2), 15579908 (1)
breast cancer	38.24	33	11175341 (5), 10022814 (5), 8058337 (3), 9390033 (2) (see all 16)
neoplastic transformation	33.51	2	8084588 (1), 8662827 (1)
leukemia	22.72	9	9096689 (1), 15143164 (1), 15050920 (1), 10887132 (1) (see all 8)
leukemogenesis	21.61	2	15143164 (2)
tumors	16.03	30	11606575 (2), 16309242 (2), 15958587 (2), 12850474 (1) (see all 25)
cancer	14.38	18	18620523 (2), 9009162 (1), 18216394 (1), 12878216 (1) (see all 13)
myeloproliferative disorders	7.72	1	10887132 (1)
melanoma	5.52	1	10091608 (1)

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Human Genome Epidemiology Navigator: GRB2 (5 documents)
Tumor Gene Database: GRB2

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1035 PubMed articles for GRB2 gene (see all 1035 ):

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine- phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. (PubMed id 8491186)^{1, 3, 4} Skolnik E.Y....Schlessinger J. (1993)
Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2. (PubMed id 8723348)^{1, 3, 4} Kavanaugh W.M....Williams L.T. (1996)
Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. (PubMed id 11827484)^{1, 3, 4} Nioche P.... Ducruix A. (2002)
Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2. (PubMed id 11533253)^{1, 3, 4} Wheeler M. and Domin J. (2001)
Solution structure and ligand-binding site of the carboxy-terminal SH3 domain of GRB2. (PubMed id 7881903)^{1, 3, 4} Kohda D.... Inagaki F. (1994)
Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2. (PubMed id 8388384)^{1, 3, 4} Tobe K.... Kadowaki T. (1993)
Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin. (PubMed id 10942756)^{1, 3, 4} Asazuma N.... Watson S.P. (2000)
Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. (PubMed id 10022120)^{1, 3, 4} Elly C....Liu Y.-C. (1999)
Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1). (PubMed id 10090780)^{1, 3, 4} Ettmayer P.... Bair K.W. (1999)
The gene structure of the human growth factor bound protein GRB2. (PubMed id 10051406)^{1, 3, 4} Bochmann H.... Jaross W. (1999)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2885	HGNC: 4566	AceView: GRB2	Ensembl:ENSG00000177885	euGenes: HUgn2885
ECgene: GRB2	H-InvDB: GRB2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for GRB2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for GRB2
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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
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Products for GRB2:

TaqMan ® Gene Expression Assays

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GRB2 Gene

protein-coding GIFtS: 71

Aliases &
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for GRB2

Genomic Location
for GRB2

Proteins
for GRB2

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for GRB2

Gene Function
for GRB2

Pathways & Interactions
for GRB2

Drugs & Compounds
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Transcripts
for GRB2

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Search for GRB2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GRB2 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor GRB2

Summariesfor GRB2

Genomic Locationfor GRB2

Proteinsfor GRB2

Protein Domains/Familiesfor GRB2

Gene Functionfor GRB2

Pathways & Interactionsfor GRB2

Drugs & Compoundsfor GRB2

Transcriptsfor GRB2

Expression for GRB2

Orthologsfor GRB2

Paralogsfor GRB2

SNPs/Variantsfor GRB2

Disorders & Mutationsfor GRB2

Medical Newsfor GRB2

Publicationsfor GRB2

Search for GRB2

Genome Databases showing GRB2

Other Databases showing GRB2

Specialized Databases showing GRB2

Licensable Technologiesfor GRB2

Servicesfor GRB2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GRB2

Summaries
for GRB2

Genomic Location
for GRB2

Proteins
for GRB2

Protein Domains/
Families
for GRB2

Gene Function
for GRB2

Pathways & Interactions
for GRB2

Drugs & Compounds
for GRB2

Transcripts
for GRB2

Expression
for GRB2

Orthologs
for GRB2

Paralogs
for GRB2

SNPs/Variants
for GRB2

Disorders & Mutations
for GRB2

Medical News
for GRB2

Publications
for GRB2

Licensable Technologies
for GRB2

Services
for GRB2