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Aliases for GRB14 Gene

Aliases for GRB14 Gene

  • Growth Factor Receptor-Bound Protein 14 2 3
  • GRB14 Adapter Protein 4

External Ids for GRB14 Gene

Previous GeneCards Identifiers for GRB14 Gene

  • GC02M163404
  • GC02M163891
  • GC02M165313
  • GC02M165551
  • GC02M165174
  • GC02M165057
  • GC02M157231
  • GC02M165350

Summaries for GRB14 Gene

Entrez Gene Summary for GRB14 Gene

  • The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for GRB14 Gene

GRB14 (Growth Factor Receptor-Bound Protein 14) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Hemostasis. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is GRB10.

UniProtKB/Swiss-Prot for GRB14 Gene

  • Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

Gene Wiki entry for GRB14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRB14 Gene

Genomics for GRB14 Gene

Regulatory Elements for GRB14 Gene

Genomic Location for GRB14 Gene

Chromosome:
2
Start:
164,492,406 bp from pter
End:
164,621,850 bp from pter
Size:
129,445 bases
Orientation:
Minus strand

Genomic View for GRB14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRB14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRB14 Gene

Proteins for GRB14 Gene

  • Protein details for GRB14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14449-GRB14_HUMAN
    Recommended name:
    Growth factor receptor-bound protein 14
    Protein Accession:
    Q14449
    Secondary Accessions:
    • B7Z7F9
    • Q7Z6I1

    Protein attributes for GRB14 Gene

    Size:
    540 amino acids
    Molecular mass:
    60988 Da
    Quaternary structure:
    • Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor (INSR), through the SH2 domain (By similarity). Interacts with GRB14 (via BPS domain); this interaction protects the tyrosines in the activation loop on INSR from dephosphorylation. Binds to the ankyrin repeat region of TNKS2 via its N-terminus. Interacts with activated NRAS. Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated).

    Three dimensional structures from OCA and Proteopedia for GRB14 Gene

    Alternative splice isoforms for GRB14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRB14 Gene

Proteomics data for GRB14 Gene at MOPED

Post-translational modifications for GRB14 Gene

  • Phosphorylated on serine residues. Phosphorylated on tyrosine residues by TEK/TIE2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GRB14 Gene

Antibody Products

No data available for DME Specific Peptides for GRB14 Gene

Domains & Families for GRB14 Gene

Protein Domains for GRB14 Gene

Suggested Antigen Peptide Sequences for GRB14 Gene

Graphical View of Domain Structure for InterPro Entry

Q14449

UniProtKB/Swiss-Prot:

GRB14_HUMAN :
  • The PH domain binds relatively non-specifically and with low affinity to several phosphoinositides, the best binder being PI(3,4,5)P3.
  • Belongs to the GRB7/10/14 family.
Domain:
  • The PH domain binds relatively non-specifically and with low affinity to several phosphoinositides, the best binder being PI(3,4,5)P3.
  • Contains 1 PH domain.
  • Contains 1 Ras-associating domain.
  • Contains 1 SH2 domain.
Family:
  • Belongs to the GRB7/10/14 family.
genes like me logo Genes that share domains with GRB14: view

Function for GRB14 Gene

Molecular function for GRB14 Gene

GENATLAS Biochemistry:
growth factor receptor bound protein 14,homolog to C elegans mig 10 gene,widely expressed,involved in signal transduction
UniProtKB/Swiss-Prot Function:
Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

Gene Ontology (GO) - Molecular Function for GRB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with GRB14: view
genes like me logo Genes that share phenotypes with GRB14: view

Animal Model Products

miRNA for GRB14 Gene

miRTarBase miRNAs that target GRB14

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRB14

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GRB14 Gene

Localization for GRB14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRB14 Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Upon insulin stimulation, translocates to the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRB14 Gene COMPARTMENTS Subcellular localization image for GRB14 gene
Compartment Confidence
endosome 5
golgi apparatus 5
cytosol 4
plasma membrane 4
nucleus 2

Gene Ontology (GO) - Cellular Components for GRB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IDA 11278563
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA 11278563
GO:0010008 endosome membrane IEA --
genes like me logo Genes that share ontologies with GRB14: view

Pathways & Interactions for GRB14 Gene

genes like me logo Genes that share pathways with GRB14: view

Pathways by source for GRB14 Gene

Gene Ontology (GO) - Biological Process for GRB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007596 blood coagulation TAS --
GO:0009967 positive regulation of signal transduction IEA --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with GRB14: view

No data available for SIGNOR curated interactions for GRB14 Gene

Drugs & Compounds for GRB14 Gene

(1) Drugs for GRB14 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
tyrosine Nutra 547

(1) Additional Compounds for GRB14 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphotyrosine
genes like me logo Genes that share compounds with GRB14: view

Transcripts for GRB14 Gene

Unigene Clusters for GRB14 Gene

Growth factor receptor-bound protein 14:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRB14

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRB14 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3: - - - - - -
SP4: - -
SP5: - - - - -
SP6: -
SP7:
SP8: -
SP9: - - - - - -

Relevant External Links for GRB14 Gene

GeneLoc Exon Structure for
GRB14
ECgene alternative splicing isoforms for
GRB14

Expression for GRB14 Gene

mRNA expression in normal human tissues for GRB14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRB14 Gene

This gene is overexpressed in Liver (x12.2), Kidney - Cortex (x4.9), and Adrenal Gland (x4.6).

Protein differential expression in normal tissues from HIPED for GRB14 Gene

This gene is overexpressed in Testis (45.3) and Liver (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GRB14 Gene



SOURCE GeneReport for Unigene cluster for GRB14 Gene Hs.411881

mRNA Expression by UniProt/SwissProt for GRB14 Gene

Q14449-GRB14_HUMAN
Tissue specificity: Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle
genes like me logo Genes that share expression patterns with GRB14: view

Protein tissue co-expression partners for GRB14 Gene

Primer Products

In Situ Assay Products

Orthologs for GRB14 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRB14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GRB14 35
  • 94.81 (n)
  • 97.04 (a)
GRB14 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRB14 35
  • 95.56 (n)
  • 97.5 (a)
GRB14 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grb14 35
  • 85.38 (n)
  • 86.06 (a)
Grb14 16
Grb14 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GRB14 35
  • 99.14 (n)
  • 98.89 (a)
GRB14 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grb14 35
  • 85.01 (n)
  • 85.32 (a)
oppossum
(Monodelphis domestica)
Mammalia GRB14 36
  • 25 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRB14 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRB14 35
  • 79.84 (n)
  • 82.33 (a)
GRB14 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRB14 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grb14 35
  • 69.36 (n)
  • 64.43 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100334415 35
  • 65.81 (n)
  • 67.06 (a)
CABZ01083696.1 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pico 36
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mig-10 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10684 36
  • 35 (a)
OneToMany
Species with no ortholog for GRB14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRB14 Gene

ENSEMBL:
Gene Tree for GRB14 (if available)
TreeFam:
Gene Tree for GRB14 (if available)

Paralogs for GRB14 Gene

Paralogs for GRB14 Gene

(4) SIMAP similar genes for GRB14 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with GRB14: view

Variants for GRB14 Gene

Sequence variations from dbSNP and Humsavar for GRB14 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs11765 -- 164,492,953(-) AAAAC(A/G)TTACC utr-variant-3-prime
rs15270 -- 164,573,640(-) GNTGA(A/G)AAAAA intron-variant
rs474066 -- 164,512,078(-) cgcag(G/T)ccttc intron-variant
rs551160 -- 164,496,779(+) AGATA(C/T)TCTAT intron-variant
rs557632 -- 164,496,035(-) TTGGA(A/T)ATAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRB14 Gene

Variant ID Type Subtype PubMed ID
nsv875365 CNV Loss 21882294

Variation tolerance for GRB14 Gene

Residual Variation Intolerance Score: 57.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.08; 95.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRB14 Gene

HapMap Linkage Disequilibrium report
GRB14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRB14 Gene

Disorders for GRB14 Gene

Relevant External Links for GRB14

Genetic Association Database (GAD)
GRB14
Human Genome Epidemiology (HuGE) Navigator
GRB14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRB14
genes like me logo Genes that share disorders with GRB14: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRB14 Gene

Publications for GRB14 Gene

  1. Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14. (PMID: 19648926) Depetris R.S. … Hubbard S.R. (Nat. Struct. Mol. Biol. 2009) 23 67
  2. Endosomal proteolysis of internalised [ArgA0]-human insulin at neutral pH generates the mature insulin peptide in rat liver in vivo. (PMID: 19834685) Kouach M. … Authier F. (Diabetologia 2009) 23 67
  3. Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor. (PMID: 16582879) Nouaille S. … Issad T. (EMBO Rep. 2006) 23 67
  4. GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle. (PMID: 16849634) Park J.J. … Hoffman E.P. (Physiol. Genomics 2006) 23 67
  5. Interaction between the insulin receptor and Grb14: a dynamic study in living cells using BRET. (PMID: 16934761) Nouaille S. … Issad T. (Biochem. Pharmacol. 2006) 23 67

Products for GRB14 Gene

Sources for GRB14 Gene

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