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GRB10 Gene

protein-coding   GIFtS: 64
GCID: GC07M050657

Growth Factor Receptor-Bound Protein 10

  See GRB10-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Growth Factor Receptor-Bound Protein 101 2     IRBP2
Insulin Receptor-Binding Protein Grb-IR2 3     MEG12
GRB10 Adapter Protein2 3     GRB10 Adaptor Protein2
RSS2 5     Maternally Expressed Gene 12
GRB-IR2     GRBIR3
Grb-102     KIAA02073

External Ids:    HGNC: 45641   Entrez Gene: 28872   Ensembl: ENSG000001060707   OMIM: 6015235   UniProtKB: Q133223   

Export aliases for GRB10 gene to outside databases

Previous GC identifers: GC07M050121 GC07M050365 GC07M050399 GC07M050431 GC07M050625


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GRB10 Gene:
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of
receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein
that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms
of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is
imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in
the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants
encoding different isoforms have been identified. (provided by RefSeq, Oct 2010)

GeneCards Summary for GRB10 Gene:
GRB10 (growth factor receptor-bound protein 10) is a protein-coding gene. Diseases associated with GRB10 include albright's hereditary osteodystrophy, and silver-russell syndrome. GO annotations related to this gene include phospholipid binding and insulin receptor binding. An important paralog of this gene is APBB1IP.

UniProtKB/Swiss-Prot: GRB10_HUMAN, Q13322
Function: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific
signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the
insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2
mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1
phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and
prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R
ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May
play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation.
Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the
binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated
degradation of KDR/VEGFR-2

Gene Wiki entry for GRB10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GRB10 gene promoter:
         Bach1   Elk-1   Meis-1b   c-Ets-1   PPAR-alpha   POU2F1   POU2F1a   c-Myb   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 9): GRB10 promoter sequence
   Search Chromatin IP Primers for GRB10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRB10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p12.2   Ensembl cytogenetic band:  7p12.1   HGNC cytogenetic band: 7p12.2

GRB10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRB10 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M050657:  view genomic region     (about GC identifiers)

Start:
50,657,760 bp from pter      End:
50,861,159 bp from pter
Size:
203,400 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 50,663,826-50,867,195     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GRB10_HUMAN, Q13322 (See protein sequence)
Recommended Name: Growth factor receptor-bound protein 10  
Size: 594 amino acids; 67231 Da
Subunit: Interacts with ligand-activated tyrosine kinase receptors, including FGFR1, INSR, IGF1R, MET and PDGFRB
in a phosphotyrosine-dependent manner through the SH2 domain (By similarity). Poorly binds to the EGFR (By
similarity). Directly interacts with MAP3K14/NIK and is recruited to the EGFR-ERBB2 complex. Interacts with
GIGYF1/PERQ1 and GIGYF2/TNRC15 (By similarity). When unphosphorylated, interacts with AKT1 and when
phosphorylated with YWHAE/14-3-3 epsilon. Interacts with NEDD4. Interacts with LRP6, thus interfering with the
binding of AXIN1 to LRP6 (By similarity). Binds to activated NRAS
Miscellaneous: The GRB10 locus is imprinted. During embryonic development, the expression in the brain and spinal
cord is from the paternal allele, while in placental villous trophoblasts and skeletal muscle, it is from the
maternal one. Expression is biallelic in most other tissues. Paternal expression in the brain is maintained
throughout adulthood. Imprinting often is isoform-specific
Miscellaneous: GRB10 is unlikely to be responsible for Silver-Russell syndrome (SRS)
Sequence caution: Sequence=BAA13198.2; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for GRB10:
1NRV (3D)        3HK0 (3D)    
Secondary accessions: A4D258 A7VJ95 A8K0E6 D3DVM9 O00427 O00701 O75222 Q92606 Q92907 Q92948
Alternative splicing: 4 isoforms:  Q13322-1   Q13322-2   Q13322-3   Q13322-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GRB10: NX_Q13322

Explore proteomics data for GRB10 at MOPED

Post-translational modifications: 

  • Phosphorylated on serine residues upon EGF, FGF and PDGF stimulation (By similarity). Phosphorylated at Tyr-67 by
    TEC1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GRB10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001001549.1  NP_001001550.1  NP_001001555.1  NP_005302.3  

    ENSEMBL proteins: 
     ENSP00000385189   ENSP00000385544   ENSP00000385366   ENSP00000349818   ENSP00000385046  
     ENSP00000385770   ENSP00000385748   ENSP00000410920   ENSP00000413023   ENSP00000381793  
     ENSP00000406716   ENSP00000338543   ENSP00000381790  
    Reactome Protein details: Q13322

    GRB10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for GRB10
    OriGene Protein Over-expression Lysate for GRB10
    OriGene MassSpec for GRB10
    OriGene Custom Protein Services for GRB10
    GenScript Custom Purified and Recombinant Proteins Services for GRB10
    Novus Biologicals GRB10 Proteins
    Novus Biologicals GRB10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GRB10 

    GRB10 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GRB10
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for GRB10 
    OriGene Antibodies for GRB10
    OriGene Custom Antibody Services for GRB10
    Novus Biologicals GRB10 Antibodies
    Abcam antibodies for GRB10
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for GRB10
    LSBio Antibodies in human, mouse, rat for GRB10

    GRB10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GRB10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GRB10
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for GRB10 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    SH2D: SH2 domain containing

    5 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR000159 Ras-assoc
     IPR015042 BPS-dom
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q13322

    ProtoNet protein and cluster: Q13322

    3 Blocks protein domains:
    IPB000159 RA domain
    IPB000980 SH2 domain signature
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: GRB10_HUMAN, Q13322
    Domain: The PH domain binds relatively non-specifically to several phosphoinositides, including PI(5)P, PI(4,5)P2,
    PI(3,4)P2 and PI(3,4,5)P3, with modest affinities
    Similarity: Belongs to the GRB7/10/14 family
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Ras-associating domain
    Similarity: Contains 1 SH2 domain


    Find genes that share domains with GRB10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRB10_HUMAN, Q13322
    Function: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific
    signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the
    insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2
    mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1
    phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and
    prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R
    ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May
    play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation.
    Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the
    binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated
    degradation of KDR/VEGFR-2
    Enzyme regulation: Phosphorylation by mTORC1 stabilizes and activates GRB10 constituting a feedback pathway by
    which mTORC1 inhibits INSR-dependent signaling

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity IEA--
    GO:0005158insulin receptor binding ISS--
    GO:0005515protein binding IPI15060076
         
    Find genes that share ontologies with GRB10           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Grb10):
     cellular  embryogenesis  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     liver/biliary system  mortality/aging  muscle  respiratory system 

    Find genes that share phenotypes with GRB10           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GRB10: Grb10tm1.1Fuis Grb10tm1Fuis

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRB10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GRB10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRB10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GRB10

    miRNA
    Products:
        
    miRTarBase miRNAs that target GRB10:
    hsa-mir-335-5p (MIRT019136), hsa-mir-222-3p (MIRT046714), hsa-mir-130b-3p (MIRT020299), hsa-mir-877-5p (MIRT037307)

    Block miRNA regulation of human, mouse, rat GRB10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GRB10 (see all 96):
    hsa-miR-548j hsa-miR-3938 hsa-miR-15a hsa-miR-1245 hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidGRB10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GRB10
    Predesigned siRNA for gene silencing in human, mouse, rat GRB10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GRB10

    Clone
    Products:
         
    OriGene clones in human, mouse for GRB10 (see all 27)
    OriGene ORF clones in mouse, rat for GRB10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): GRB10 (NM_005311)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRB10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRB10
    Addgene plasmids for GRB10 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GRB10
    Browse ESI BIO Cell Lines and PureStem Progenitors for GRB10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRB10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GRB10_HUMAN, Q13322: Cytoplasm (By similarity). Note=When complexed with NEDD4 and IGF1R, follows IGF1R
    internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the
    sorting of the receptor to the lysosomal compartment (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane4
    nucleus2
    cytoskeleton1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS9006901
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS9006901

    Find genes that share ontologies with GRB10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GRB10 About   (see all 17)  
    See pathways by source

    SuperPathContained pathways About
    1Kit Receptor Signaling Pathway
    Signaling events mediated by Stem cell factor receptor (c-Kit)0.37
    Kit Receptor Signaling Pathway0.37
    2Insulin receptor signalling cascade
    Insulin receptor signalling cascade0.94
    Signal attenuation0.00
    Signaling by Insulin receptor0.80
    3PI-3K cascade
    Signaling by SCF-KIT0.72
    4GPCR Pathway
    Breast Cancer Regulation by Stathmin10.58
    5Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with GRB10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GRB10
        Breast Cancer Regulation by Stathmin1
    Caspase Cascade
    Insulin Receptor Pathway

    2 Cell Signaling Technology (CST) Pathways for GRB10
        Tyrosine Kinases / Adaptors
    PI3K / Akt Signaling

    1 GeneGo (Thomson Reuters) Pathway for GRB10
        Cell adhesion Ephrins signaling

    Selected BioSystems Pathways for GRB10 (see all 9)
        EGFR1 Signaling Pathway
    Insulin Signaling
    Kit Receptor Signaling Pathway
    Signaling events mediated by VEGFR1 and VEGFR2
    IGF1 pathway

    2 Reactome Pathways for GRB10
        Signal attenuation
    Signaling by SCF-KIT


        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRB10: 
              Insulin Signaling Pathway in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GRB10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GRB10 (Q133221, 2, 3 ENSP000003817934) via UniProtKB, MINT, STRING, and/or I2D (see all 208)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EPHB1P547621, 3, ENSP000003810974EBI-80275,EBI-80252 I2D: score=4 STRING: ENSP00000381097
    PDGFRBP096192, 3, ENSP000002617994MINT-8027003 I2D: score=3 STRING: ENSP00000261799
    ABI1Q8IZP02, 3, ENSP000003653124MINT-7908267 I2D: score=1 STRING: ENSP00000365312
    DDX39BQ138383I2D: score=1 
    ENSG00000215425Q138383I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0008286insulin receptor signaling pathway TAS--
    GO:0030178negative regulation of Wnt signaling pathway IDA17376403
    GO:0030949positive regulation of vascular endothelial growth factor receptor signaling pathway IDA15060076
    GO:0032868response to insulin ISS--

    Find genes that share ontologies with GRB10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GRB10

    2 Novoseek inferred chemical compound relationships for GRB10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 58.7 38 10871840 (7), 8798570 (2), 11494124 (2), 10454568 (2) (see all 18)
    vegf 7.98 12 11494124 (4), 15060076 (2), 15870923 (1)



    Find genes that share compounds with GRB10           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GRB10 gene (4 alternative transcripts): 
    NM_001001549.2  NM_001001550.2  NM_001001555.2  NM_005311.4  

    Unigene Cluster for GRB10:

    Growth factor receptor-bound protein 10
    Hs.164060  [show with all ESTs]
    Unigene Representative Sequence: D86962
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000402578 ENST00000403097(uc003tpl.2) ENST00000406641 ENST00000357271
    ENST00000407526 ENST00000401949 ENST00000402497 ENST00000461886 ENST00000473696
    ENST00000482397 ENST00000428711 ENST00000439044 ENST00000465602 ENST00000483819
    ENST00000470992 ENST00000483157 ENST00000492265 ENST00000467386
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GRB10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GRB10 (see all 96):
    hsa-miR-548j hsa-miR-3938 hsa-miR-15a hsa-miR-1245 hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidGRB10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GRB10
    Predesigned siRNA for gene silencing in human, mouse, rat GRB10
    Clone
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    OriGene clones in human, mouse for GRB10 (see all 27)
    OriGene ORF clones in mouse, rat for GRB10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): GRB10 (NM_005311)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRB10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRB10
    Addgene plasmids for GRB10 
    Primer
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    OriGene qPCR primer pairs and template standards for GRB10
    OriGene qSTAR qPCR primer pairs in human, mouse for GRB10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GRB10
      QuantiTect SYBR Green Assays in human, mouse, rat GRB10
      QuantiFast Probe-based Assays in human, mouse, rat GRB10

    Additional mRNA sequence: 

    AB000731.1 AF000017.1 AF000018.1 AF001534.1 AJ271366.1 AK289511.1 BC024285.1 BX649028.1 
    D86962.1 U34355.1 U66065.1 U69276.1 

    20 DOTS entries:

    DT.75179240  DT.100815693  DT.100668951  DT.95171045  DT.101957696  DT.100037150  DT.40128112  DT.65285696 
    DT.95171047  DT.121047070  DT.95171048  DT.97815311  DT.102833078  DT.92005045  DT.95171034  DT.121047021 
    DT.75185513  DT.92044451  DT.95140647  DT.97783544 

    Selected AceView cDNA sequences (see all 208):

    NM_001001550 BQ216421 BM744655 W24210 CB243699 U34355 BM851823 AI023919 
    AW964788 AF000017 NM_001001549 BU741563 BM674022 CK820530 AW665655 F28925 
    CB119808 CB114858 NM_001001555 AK021643 BE384766 BQ446842 D86962 CA308838 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GRB10 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^
    SP1:                                -     -     -     -     -           -     -     -     -                       -     -     -                                 
    SP2:                                                                                                  -     -     -     -     -                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                              -     -     -                                 
    SP5:                    -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                                 

    ExUns: 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b · 24c ^ 25a · 25b
    SP1:                                -                 -                 -                           
    SP2:                                -                 -                 -                           
    SP3:                                -                 -                 -                           
    SP4:              -                 -                 -                 -                           
    SP5:                                                                                                


    ECgene alternative splicing isoforms for GRB10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    GRB10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTTTGCTT
    GRB10 Expression
    About this image


    GRB10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Heart (Cardiovascular System)
             Cushion Mesenchymal Cells Endocardium
     
     Testis (Reproductive System)
             Testicular Interstitial Cells Testis Interstitium
     
     Limb (Muscoskeletal System)
             Limb Bud
    GRB10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GRB10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.164060

    UniProtKB/Swiss-Prot: GRB10_HUMAN, Q13322
    Tissue specificity: Widely expressed in fetal and adult tissues, including fetal and postnatal liver, lung,
    kidney, skeletal muscle, heart, spleen, skin and brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRB10: 
              Insulin Signaling Pathway in human mouse rat
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRB10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GRB10 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grb101 , 5 growth factor receptor bound protein 101, 5 81.36(n)1
    86.68(a)1
      11 (7.15 cM)5
    147831  NM_010345.41  NP_034475.21 
     119305085 
    chicken
    (Gallus gallus)
    Aves GRB101 growth factor receptor-bound protein 10 79.28(n)
    86.97(a)
      420948  NM_001039282.1  NP_001034371.1 
    lizard
    (Anolis carolinensis)
    Reptilia GRB106
    growth factor receptor-bound protein 10
    84(a)
    1 ↔ 1
    6(54497330-54584373)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ049341.12   -- 80.7(n)    BJ049341.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CD599583.12   -- 76.47(n)    CD599583.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pico6
    pico
    11(a)
    1 → many
    X(19724248-19746092)
    worm
    (Caenorhabditis elegans)
    Secernentea mig-106
    Protein MIG-10, isoform c
    14(a)
    1 → many
    III(8279108-8305832) WBGene00003243


    ENSEMBL Gene Tree for GRB10 (if available)
    TreeFam Gene Tree for GRB10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GRB10 gene
    APBB1IP2  GRB72  RAPH12  GRB142  
    3 SIMAP similar genes for GRB10 using alignment to 5 protein entries:     GRB10_HUMAN (see all proteins):
    GRB14    GRB7    RAPH1

    Find genes that share paralogs with GRB10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GRB10 (see all 4589)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30400261,2
    C--50594013(+) GGGGG-/G/G   
       G
    /GGG
    TTGTA
    4 -- int11NA 2
    rs1436063461,2
    C--50606761(+) TTTATA/GGGGGA 4 -- int10--------
    rs1838481441,2
    --50606835(+) TCTCAC/TGAGGG 4 -- int10--------
    rs794087061,2
    F--50606886(+) ATTCCT/GTGTGA 4 -- int11Minor allele frequency- G:0.01WA 118
    rs1465046661,2
    --50607075(+) TTCAAA/GTGATT 4 -- int10--------
    rs1411057251,2
    --50607114(+) GATTAC/TAGGTG 4 -- int10--------
    rs1881230531,2
    --50607120(+) AGGTGC/TGCACC 4 -- int10--------
    rs2002727421,2
    --50607187(+) GCTGG-/TCTTCG 4 -- int10--------
    rs126725261,2
    C,A,H--50607188(+) GCTGGC/TTTCGA 4 -- int14Minor allele frequency- T:0.46NA EA 244
    rs77891671,2
    C,F,H--50607189(+) CTGGCC/TTCGAA 4 -- int113Minor allele frequency- T:0.01NS NA WA CSA EA 746

    HapMap Linkage Disequilibrium report for GRB10 (50657760 - 50861159 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for GRB10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734380CNV Deletion23290073
    nsv5738CNV Insertion18451855
    esv24304CNV Loss19812545
    nsv521070CNV Loss19592680
    esv275051CNV Loss21479260
    nsv824091CNV Gain20364138
    nsv824092CNV Gain20364138

    Human Gene Mutation Database (HGMD): GRB10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GRB10
    DNA2.0 Custom Variant and Variant Library Synthesis for GRB10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601523    OMIM disorders: --

    2 diseases for GRB10:    
    About MalaCards
    albright's hereditary osteodystrophy    silver-russell syndrome

    2 diseases from the University of Copenhagen DISEASES database for GRB10:
    Silver-Russell syndrome     Beckwith-Wiedemann syndrome

    Find genes that share disorders with GRB10           About GenesLikeMe

    4 Novoseek inferred disease relationships for GRB10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    growth retardation 28.5 1 12514746 (1)
    metastasis 0 1 15724012 (1)
    melanoma 0 2 15724012 (1)
    cancer 0 1 15870923 (1)

    Genetic Association Database (GAD): GRB10
    Human Genome Epidemiology (HuGE) Navigator: GRB10 (3 documents)

    Export disorders for GRB10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GRB10 gene, integrated from 10 sources (see all 134):
    (articles sorted by number of sources associating them with GRB10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway. (PubMed id 17376403)1, 2, 9 Tezuka N.... Yanagawa S. (Biochem. Biophys. Res. Commun. 2007)
    2. Grb10 mediates insulin-stimulated degradation of the insulin receptor: a mechanism of negative regulation. (PubMed id 16434550)1, 2, 9 Ramos F.J.... Liu F. (Am. J. Physiol. 2006)
    3. Imprinting of human GRB10 and its mutations in two patients with Russell-Silver syndrome. (PubMed id 10856193)1, 2, 9 Yoshihashi H.... Kosaki K. (Am. J. Hum. Genet. 2000)
    4. Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation. (PubMed id 15060076)1, 2, 9 Murdaca J.... Giorgetti-Peraldi S. (J. Biol. Chem. 2004)
    5. Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling. (PubMed id 8798417)1, 2, 9 O'Neill T.J....Gustafson T.A. (J. Biol. Chem. 1996)
    6. Phosphorylation of Grb10 by mitogen-activated protein kinase: identification of Ser150 and Ser476 of human Grb10zeta as major phosphorylation sites. (PubMed id 15952796)1, 2, 9 Langlais P.... Liu F. (Biochemistry 2005)
    7. Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue- and isoform-specific fashion. (PubMed id 10861285)1, 2, 9 Blagitko N.... Kalscheuer V.M. (Hum. Mol. Genet. 2000)
    8. Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14. (PubMed id 19648926)1, 2, 9 Depetris R.S.... Hubbard S.R. (Nat. Struct. Mol. Biol. 2009)
    9. Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression. (PubMed id 19487367)1, 2, 9 Monk D....Moore G.E. (Hum. Mol. Genet. 2009)
    10. Lack of association of birth size with polymorphisms of two imprinted genes, IGF2R and GRB10. (PubMed id 15506681)1, 4, 9 Kukuvitis A....Polychronakos C. (amp 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2887 HGNC: 4564 AceView: GRB10 Ensembl:ENSG00000106070 euGenes: HUgn2887
    ECgene: GRB10 H-InvDB: GRB10

    (According to HUGE)
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    HUGE: KIAA0207

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GRB10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GRB10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GRB10 gene:
    Search GeneIP for patents involving GRB10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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