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GRB10 Gene

protein-coding GIFtS: 68

GC07M050625

growth factor receptor-bound protein 10
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
GRB-IR ^²
GRBIR ^³
Grb-10 ^²
IRBP ^²
KIAA0207 ^², ³
MEG1 ^²
RSS ^², ⁵

Descriptions
GRB10 adapter protein ^³
GRB10 adaptor protein ^²
Insulin receptor-binding protein Grb-IR ^², ³
growth factor receptor-bound protein 10 ^²
maternally expressed gene 1 ^²

External Ids
HGNC: 4564¹
Entrez Gene: 2887²
UniProtKB: Q13322³
Ensembl: ENSG00000106070⁷

Search outside databases for aliases for GRB10 gene

Previous GC identifers: GC07M050121 GC07M050365 GC07M050399 GC07M050431

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GRB10:

The product of this gene belongs to a small family of adapter proteins that are known to interact

with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth

factor receptor-binding protein that interacts with insulin receptors and insulin-like

growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine

kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and

tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have

been identified. [provided by RefSeq]

UniProtKB/Swiss-Prot: GRB10_HUMAN, Q13322

Function: Plays a functional role in insulin and IGF-I signaling. May serve to positively link the

insulin and IGF-I receptors to an uncharacterized mitogenic signaling pathway. Interacts with the

cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. The

interaction is mediated by the SH2 domain. Also binds activated platelet-derived growth factor

receptor and epidermal growth factor receptor

Gene Wiki entry for GRB10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GRB10 gene

Entrez Gene cytogenetic band: 7p12-p11.2 Ensembl cytogenetic band: 7p12.2 HGNC cytogenetic band: 7p12.2

GRB10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M050625: (about GC identifiers)

Start:	50,625,259 bp from pter
End:	50,828,652 bp from pter
Size:	203,394 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 50,663,831-50,867,194

RefSeq DNA sequence:

NC_000007.12 NT_033968.5 NT_079592.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GRB10_HUMAN, Q13322 (See protein sequence)

Recommended Name: Growth factor receptor-bound protein 10

Size: 594 amino acids; 67231 Da

Subunit: Interacts with GIGYF1/PERQ1 and GIGYF2/TNRC15 (By similarity)

PDB structures from and Proteopedia :

1NRV (3D)

Secondary accessions: A7VJ95 O00427 O00701 O75222 Q92606 Q92907 Q92948

Alternative splicing: 3 isoforms: Q13322-1 Q13322-2 Q13322-3 (Additional isoforms seem to exist)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001001549.1 NP_001001550.1 NP_001001555.1 NP_005302.3

ENSEMBL proteins:

ENSP00000385046 ENSP00000385748 ENSP00000381771 ENSP00000385366 ENSP00000385189 ENSP00000338543

ENSP00000381790 ENSP00000385544 ENSP00000385770 ENSP00000381793 ENSP00000349818

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GRB10, GRB 10)
	Human Recombinant Proteins from Abnova (GRB10)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	9006901
GO:0005886	plasma membrane	TAS	9006901

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Antibodies for GRB10:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for GRB10
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for GRB10
	Antibodies from Abcam (GRB10, GRB 10), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GRB10)
	Novus Biologicals Antibodies for GRB10

Assays for GRB10:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q13322

ProtoNet protein and cluster: Q13322

3 Blocks protein families:

IPB000159 RA domain

IPB000980 SH2 domain signature

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: GRB10_HUMAN, Q13322

Similarity: Belongs to the GRB7/10/14 family

Similarity: Contains 1 PH domain

Similarity: Contains 1 Ras-associating domain

Similarity: Contains 1 SH2 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GRB10)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GRB10)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001001549

Applied Biosystems Silencer® siRNAs for GRB10

Sigma-Aldrich siRNA for GRB10

Sigma-Aldrich shRNA for GRB10

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GRB10
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001001549
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001001549
untagged cDNA clones in CMV expression vector (see all 7): AJ271366

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005311

UniProtKB/Swiss-Prot: GRB10_HUMAN, Q13322

Function: Plays a functional role in insulin and IGF-I signaling. May serve to positively link the

insulin and IGF-I receptors to an uncharacterized mitogenic signaling pathway. Interacts with the

cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. The

interaction is mediated by the SH2 domain. Also binds activated platelet-derived growth factor

receptor and epidermal growth factor receptor

9 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Grb10):

cellular	digestive/alimentary	embryogenesis	endocrine/exocrine gland	growth/size
homeostasis/metabolism	liver/biliary system	muscle	respiratory system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005070	SH3/SH2 adaptor activity	TAS	9006901
GO:0005515	protein binding	IPI	8798570 17474147

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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for GRB10 (Your Favorite Gene powered by Ingenuity)

IGF-1 Signaling
Insulin Receptor Signaling

GeneDecks GRB10 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for GRB10

5/104 Interacting proteins for GRB10 (Q13322^{1, 2} ENSP00000338543³) via UniProtKB, MINT, and/or STRING (see all 104 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IGF1R	P08069², ENSP00000268035³	MINT-15643 MINT-15644 STRING (score=.999)
INSR	P06213², ENSP00000303830³	MINT-16515 MINT-16516 STRING (score=.999)
EGFR	P00533², ENSP00000275493³	MINT-16801 MINT-16802 STRING (score=.997)
EPHB1	P54762¹, ENSP00000354191³	EBI-80275, EBI-80252 STRING (score=.783)
GRB2	P62993¹	EBI-80275, EBI-401755

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0007267	cell-cell signaling	TAS	9006901
GO:0008286	insulin receptor signaling pathway	TAS	9006901

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for GRB10

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GRB10
1 Novoseek chemical compound relationship for GRB10 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	58.75	38	10871840 (7), 8798570 (2), 11494124 (2), 10454568 (2) (see all 18)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GRB10)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GRB10)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001001549

Sigma-Aldrich siRNA for GRB10

Sigma-Aldrich shRNA for GRB10

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001001549 NM_001001550 NM_001001555 NM_005311

REFSEQ mRNAs for GRB10 gene (4 alternative transcripts):

NM_001001549.2 NM_001001550.2 NM_001001555.2 NM_005311.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001001549 NM_001001550 NM_001001555 NM_005311

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001001549
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001001549
                                 untagged cDNA clones in CMV expression vector (see all 7): AJ271366

Additional cDNA sequence:

AB000731.1 AF000017.1 AF000018.1 AF001534.1 AJ271366.1 AK289511.1 BC024285.1 BX649028.1

CR624299.1 D86962.1 U34355.1 U66065.1 U69276.1

20 DOTS entries:

DT.75179240 DT.100815693 DT.100668951 DT.95171045 DT.101957696 DT.100037150 DT.65285696 DT.40128112

DT.95171047 DT.97815311 DT.121047070 DT.95171048 DT.102833078 DT.121047054 DT.121047055 DT.40280950

DT.92005045 DT.97783544 DT.92044451 DT.95140647

24/208 AceView cDNA sequences (see all 208 ):

AF000017 NM_005311 CB114858 BU741563 BQ216421 F28925 CR624299 CD620215

BU195435 CB119808 BQ446842 BM674022 NM_001001549 U34355 BM851823 AW292896

AK021643 AW964788 NM_001001555 AF001534 CB115317 BM715566 BG743264 AU124788

highest scoring ESTs for GRB10:

BM453067 BM470377 BQ233156 BQ932101 BQ953144 BU598359 D86962 AA129406 AA133831 AA136336

Unigene Cluster for GRB10:

Growth factor receptor-bound protein 10

Hs.164060 [show with all ESTs]

Unigene Representative Sequence: D86962

GeneLoc Exon Structure

5/18 Alternative Splicing Database (ASD) splice patterns (SP) for GRB10 (see all 18 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	·	6d	^	7	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14	^
SP1:											-		-		-		-		-				-		-		-		-								-		-		-
SP2:																																	-		-		-		-		-
SP3:
SP4:																																					-		-		-
SP5:							-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-

ExUns:	15	^	16	^	17	^	18	^	19	^	20a	·	20b	^	21a	·	21b	^	22	^	23	^	24a	·	24b	·	24c	^	25a	·	25b
SP1:											-						-						-
SP2:											-						-						-
SP3:											-						-						-
SP4:					-						-						-						-
SP5:

About this scheme

ECgene alternative splicing isoforms for GRB10

11 Ensembl transcripts including schematic representations:

ENST00000407526 ENST00000402497 ENST00000398791 ENST00000406641 ENST00000402578 ENST00000335866

ENST00000398810 ENST00000403097 ENST00000401949 ENST00000398812 ENST00000357271

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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GRB10 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GRB10

¹ / ² / ³

10 probe-sets matching GRB10 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37615_at²^{, 3}	U95-A	1	1.00	1.00	0.62	1.24	D86962	0.80	1.00	0.91	1
90682_at²^{, 3}	U95-D	1	0.38	1.00	0.65	0.77	AA905088	0.60	1.00	0.82	1
209410_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF000017	0.60	1.00	0.82	1
215248_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AU145003	0.60	1.00	0.82	1
209409_at²^{, 3}	U133-A	1	1.00	1.00	--	--	D86962	0.80	1.00	0.91	1
210999_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U66065	0.60	1.00	0.82	1
209410_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215248_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209409_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210999_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks GRB10 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: TGCTTTGCTT

SOURCE GeneReport for Unigene cluster: Hs.164060
Expression variation in blood from EXPOLDB for GRB10
UniProtKB/Swiss-Prot: GRB10_HUMAN, Q13322
Tissue specificity: Highly expressed in skeletal muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GRB10 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	GRB10¹	--	growth factor receptor-bound protein 10	97.31(n) 96.3(a)	463410 XM_001154628.1 XP_001154628.1
cow (Bos taurus)	Grb10¹	--	growth factor receptor-bound protein 10	88.77(n) 93.33(a)	407210 XM_602256.3 XP_602256.3
rat (Rattus norvegicus)	Grb10¹	--	growth factor receptor bound protein 10	79.41(n) 82.87(a)	498416 XM_573664.2 XP_573664.2
mouse (Mus musculus)	Grb10^{1, 5}	11 (8.00 cM)⁵	growth factor receptor bound protein 10^{1, 5}	81.36(n)¹ 86.49(a)¹	14783¹ NM_010345.3¹ NP_034475.2¹ AB106541⁵ AF022072⁵ (see all 26)
chicken (Gallus gallus)	GRB10¹	--	growth factor receptor-bound protein 10	79.39(n) 87.31(a)	420948 NM_001039282.1 NP_001034371.1

About this table Species with no ortholog for GRB10

ENSEMBL Gene Tree for GRB10

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for GRB10 gene

GRB7² GRB14²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1233 NCBI SNPs in GRB10 are shown (see all 1233 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 408)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs962508^1,2	A,C,F,H,O	50768824(-)	`TCACTC/GAGTAG`	3	--	int¹ ng3¹		9		MN EU EA WA	1020
	rs6967612^1,2	A,C,F,H	50768611(+)	`AATTCT/CCATCA`	3	--	int¹ ng3¹		2		EU WA	216
	rs2529401^1,2	A,C,F,H	50741036(-)	`CACTGT/GGTGCT`	4	--	ng3¹ int¹		4		EU EA WA	418
	rs7793570^1,2	A,C,F,H	50769411(+)	`GCGGCT/CTCTGC`	3	--	ng3¹ int¹		4		EU EA WA	384
	rs4265140^1,2	C,F,H	50626458(+)	`ACTGAA/CATACA`	4	--	ut3¹ ese³		4		EU EA WA	412
	rs6961447^1,2	A,F,H	50742151(+)	`ATGACG/AAGCTT`	4	--	int¹ ng3¹		4		EU EA WA	420
	rs2529400^1,2	C,F,H	50742115(-)	`TCAGTG/AACAGA`	4	--	int¹ ng3¹		4		EU EA WA	418
	rs2715104^1,2	C,F,H	50740905(+)	`CCATCG/AGCACT`	4	--	int¹ ng3¹		8		EU EA WA	840
	rs2108350^1,2	C,F,H	50767663(-)	`CTAAGG/ACCAAG`	3	--	ng3¹ int¹		4		EU EA WA	420
	rs3807551^1,2	C,F	50627898(-)	`TCCAGC/TGGAAA`	4	--	ut3¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for GRB10 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 601523

4 Novoseek disease relationships for GRB10 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
growth retardation	30.50	1	12514746 (1)
melanoma	0.00	2	15724012 (1)
cancer	0.00	1	15870923 (1)
metastasis	0.00	1	15724012 (1)

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Human Gene Mutation Database: GRB10
Genetic Association Database: GRB10
Human Genome Epidemiology Navigator: GRB10 (2 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/103 PubMed articles for GRB10 gene (see all 103 ):

Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling. (PubMed id 8798417)^{1, 3, 4} O'Neill T.J....Gustafson T.A. (1996)
Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue- and isoform-specific fashion. (PubMed id 10861285)^{1, 3, 4} Blagitko N.... Kalscheuer V.M. (2000)
Lack of association of birth size with polymorphisms of two imprinted genes, IGF2R and GRB10. (PubMed id 15506681)^{1, 3, 6} Kukuvitis A....Polychronakos C. (2004)
Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease. (PubMed id 9881709)^{1, 3, 4} Angrist M....Chakravarti A. (1998)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{3, 4} Hillier L.W.... Wilson R.K. (2003)
Grb10/GrbIR as an in vivo substrate of Tec tyrosine kinase. (PubMed id 9753425)^{3, 4} Mano H.... Kajigaya S. (1998)
Human GRB-IR-beta/GRB10: splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains. (PubMed id 9006901)^{3, 4} Frantz J.D.... Shoelson S.E. (1997)
Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma. (PubMed id 9360986)^{3, 4} Dong L.Q....Mandarino J. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2887	HGNC: 4564	AceView: GRB10	Ensembl:ENSG00000106070	euGenes: HUgn2887
ECgene: GRB10	H-InvDB: GRB10

(According to HUGE)
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HUGE: KIAA0207

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for GRB10	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for GRB10
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GRB10:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GRB10-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GRB10		Antibodies for GRB10
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GRB10		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GRB10)
	Antibodies (GRB10)
	Chimera RNAi (GRB10)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for GRB10

	Recombinant Proteins (GRB10, GRB 10)
	Antibodies (GRB10, GRB 10)

Search OriGene for GRB10

Search Tocris compounds for GRB10

	Drugs for GRB10
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GRB10

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
GRB10 Gene at Home site.
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GRB10 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for GRB10

Summaries
for GRB10

Genomic Location
for GRB10

Proteins
for GRB10

Protein Domains/
Families
for GRB10

Gene Function
for GRB10

Pathways & Interactions
for GRB10

Drugs & Compounds
for GRB10

Transcripts
for GRB10

Expression
for GRB10

Orthologs
for GRB10

Paralogs
for GRB10

SNPs/Variants
for GRB10

Disorders & Mutations
for GRB10

Medical News
for GRB10

Publications
for GRB10

Search for GRB10

Genome Databases showing GRB10

Other Databases showing GRB10

Specialized Databases showing GRB10

Licensable Technologies
for GRB10

Services
for GRB10

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GRB10 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor GRB10

Summariesfor GRB10

Genomic Locationfor GRB10

Proteinsfor GRB10

Protein Domains/Familiesfor GRB10

Gene Functionfor GRB10

Pathways & Interactionsfor GRB10

Drugs & Compoundsfor GRB10

Transcriptsfor GRB10

Expression for GRB10

Orthologsfor GRB10

Paralogsfor GRB10

SNPs/Variantsfor GRB10

Disorders & Mutationsfor GRB10

Medical Newsfor GRB10

Publicationsfor GRB10

Search for GRB10

Genome Databases showing GRB10

Other Databases showing GRB10

Specialized Databases showing GRB10

Licensable Technologiesfor GRB10

Servicesfor GRB10

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GRB10

Summaries
for GRB10

Genomic Location
for GRB10

Proteins
for GRB10

Protein Domains/
Families
for GRB10

Gene Function
for GRB10

Pathways & Interactions
for GRB10

Drugs & Compounds
for GRB10

Transcripts
for GRB10

Expression
for GRB10

Orthologs
for GRB10

Paralogs
for GRB10

SNPs/Variants
for GRB10

Disorders & Mutations
for GRB10

Medical News
for GRB10

Publications
for GRB10

Licensable Technologies
for GRB10

Services
for GRB10