Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GRB10 Gene

Aliases for GRB10 Gene

  • Growth Factor Receptor-Bound Protein 10 2 3
  • Insulin Receptor-Binding Protein Grb-IR 3 4
  • GRB10 Adapter Protein 3 4
  • RSS 3 6
  • Maternally Expressed Gene 1 3
  • GRB10 Adaptor Protein 3
  • KIAA0207 4
  • GRB-IR 3
  • Grb-10 3
  • GRBIR 4
  • IRBP 3
  • MEG1 3

External Ids for GRB10 Gene

Summaries for GRB10 Gene

Entrez Gene Summary for GRB10 Gene

  • The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]

GeneCards Summary for GRB10 Gene

GRB10 (Growth Factor Receptor-Bound Protein 10) is a Protein Coding gene. Diseases associated with GRB10 include albright's hereditary osteodystrophy and silver-russell syndrome. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include phospholipid binding and insulin receptor binding. An important paralog of this gene is GRB14.

UniProtKB/Swiss-Prot for GRB10 Gene

  • Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.

Gene Wiki entry for GRB10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRB10 Gene

Genomics for GRB10 Gene

Genomic Location for GRB10 Gene

Start:
50,590,063 bp from pter
End:
50,793,462 bp from pter
Size:
203,400 bases
Orientation:
Minus strand

Genomic View for GRB10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRB10 Gene

Regulatory Elements for GRB10 Gene

Proteins for GRB10 Gene

  • Protein details for GRB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13322-GRB10_HUMAN
    Recommended name:
    Growth factor receptor-bound protein 10
    Protein Accession:
    Q13322
    Secondary Accessions:
    • A4D258
    • A7VJ95
    • A8K0E6
    • D3DVM9
    • O00427
    • O00701
    • O75222
    • Q92606
    • Q92907
    • Q92948

    Protein attributes for GRB10 Gene

    Size:
    594 amino acids
    Molecular mass:
    67231 Da
    Quaternary structure:
    • Interacts with ligand-activated tyrosine kinase receptors, including FGFR1, INSR, IGF1R, MET and PDGFRB in a phosphotyrosine-dependent manner through the SH2 domain (By similarity). Poorly binds to the EGFR (By similarity). Directly interacts with MAP3K14/NIK and is recruited to the EGFR-ERBB2 complex. Interacts with GIGYF1/PERQ1 and GIGYF2/TNRC15 (By similarity). When unphosphorylated, interacts with AKT1 and when phosphorylated with YWHAE/14-3-3 epsilon. Interacts with NEDD4. Interacts with LRP6, thus interfering with the binding of AXIN1 to LRP6 (By similarity). Binds to activated NRAS.
    Miscellaneous:
    • GRB10 is unlikely to be responsible for Silver-Russell syndrome (SRS)
    • The GRB10 locus is imprinted. During embryonic development, the expression in the brain and spinal cord is from the paternal allele, while in placental villous trophoblasts and skeletal muscle, it is from the maternal one. Expression is biallelic in most other tissues. Paternal expression in the brain is maintained throughout adulthood. Imprinting often is isoform-specific
    SequenceCaution:
    • Sequence=BAA13198.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GRB10 Gene

    Alternative splice isoforms for GRB10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRB10 Gene

Proteomics data for GRB10 Gene at MOPED

Post-translational modifications for GRB10 Gene

  • Phosphorylated on serine residues upon EGF, FGF and PDGF stimulation (By similarity). Phosphorylated at Tyr-67 by TEC.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GRB10 Gene

Domains for GRB10 Gene

Gene Families for GRB10 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
  • SH2D :SH2 domain containing

Suggested Antigen Peptide Sequences for GRB10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13322

UniProtKB/Swiss-Prot:

GRB10_HUMAN
Domain:
  • The PH domain binds relatively non-specifically to several phosphoinositides, including PI(5)P, PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3, with modest affinities:
    • Q13322
  • Contains 1 PH domain.:
    • Q13322
  • Contains 1 Ras-associating domain.:
    • Q13322
  • Contains 1 SH2 domain.:
    • Q13322
Family:
  • Belongs to the GRB7/10/14 family.:
    • Q13322
genes like me logo Genes that share domains with GRB10: view

Function for GRB10 Gene

Molecular function for GRB10 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Phosphorylation by mTORC1 stabilizes and activates GRB10 constituting a feedback pathway by which mTORC1 inhibits INSR-dependent signaling.
UniProtKB/Swiss-Prot Function: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.

Gene Ontology (GO) - Molecular Function for GRB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity IEA --
GO:0005158 insulin receptor binding ISS --
GO:0005515 protein binding IPI 15060076
genes like me logo Genes that share ontologies with GRB10: view
genes like me logo Genes that share phenotypes with GRB10: view

Animal Models for GRB10 Gene

MGI Knock Outs for GRB10:

miRNA for GRB10 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GRB10 Gene

Localization for GRB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRB10 Gene

Cytoplasm. Note=When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRB10 Gene COMPARTMENTS Subcellular localization image for GRB10 gene
Compartment Confidence
cytosol 4
plasma membrane 4
nucleus 2
cytoskeleton 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GRB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9006901
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS 9006901
genes like me logo Genes that share ontologies with GRB10: view

Pathways for GRB10 Gene

genes like me logo Genes that share pathways with GRB10: view

Gene Ontology (GO) - Biological Process for GRB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0008286 insulin receptor signaling pathway TAS --
GO:0030178 negative regulation of Wnt signaling pathway IDA 17376403
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IDA 15060076
GO:0032868 response to insulin ISS --
genes like me logo Genes that share ontologies with GRB10: view

Compounds for GRB10 Gene

(2) Novoseek inferred chemical compound relationships for GRB10 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 58.7 29
vegf 7.98 7
genes like me logo Genes that share compounds with GRB10: view

Transcripts for GRB10 Gene

Unigene Clusters for GRB10 Gene

Growth factor receptor-bound protein 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRB10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^
SP1: - - - - - - - - - - - -
SP2: - - - - -
SP3:
SP4: - - -
SP5: - - - - - - - - - - - - - - - - - -
SP6:
SP7: - - - - - - - - - - - - - - - -
SP8:
SP9: - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - -
SP12: - - -
SP13:
SP14: -
SP15: - - - - - - - - - -
SP16: - - - -
SP17:
SP18:

ExUns: 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b · 24c ^ 25a · 25b
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5:
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for GRB10 Gene

GeneLoc Exon Structure for
GRB10
ECgene alternative splicing isoforms for
GRB10

Expression for GRB10 Gene

mRNA expression in normal human tissues for GRB10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GRB10 Gene

SOURCE GeneReport for Unigene cluster for GRB10 Gene Hs.164060

mRNA Expression by UniProt/SwissProt for GRB10 Gene

Q13322-GRB10_HUMAN
Tissue specificity: Widely expressed in fetal and adult tissues, including fetal and postnatal liver, lung, kidney, skeletal muscle, heart, spleen, skin and brain.
genes like me logo Genes that share expressions with GRB10: view

No data available for mRNA differential expression in normal tissues for GRB10 Gene

Orthologs for GRB10 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRB10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRB10 35
  • 99.94 (n)
  • 99.83 (a)
GRB10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GRB10 35
  • 88.89 (n)
  • 93.18 (a)
GRB10 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRB10 35
  • 84.89 (n)
  • 88.73 (a)
GRB10 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grb10 35
  • 81.36 (n)
  • 86.68 (a)
Grb10 16
Grb10 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRB10 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRB10 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grb10 35
  • 83.26 (n)
  • 90.65 (a)
chicken
(Gallus gallus)
Aves GRB10 35
  • 79.28 (n)
  • 86.97 (a)
GRB10 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRB10 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grb10 35
  • 74.58 (n)
  • 83.15 (a)
Str.10026 35
zebrafish
(Danio rerio)
Actinopterygii grb10a 36
  • 71 (a)
OneToMany
grb10b 35
  • 72.21 (n)
  • 76.23 (a)
grb10b 36
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta pico 36
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mig-10 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10684 36
  • 36 (a)
OneToMany
Species with no ortholog for GRB10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRB10 Gene

ENSEMBL:
Gene Tree for GRB10 (if available)
TreeFam:
Gene Tree for GRB10 (if available)

Paralogs for GRB10 Gene

Paralogs for GRB10 Gene

Selected SIMAP similar genes for GRB10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GRB10: view

Variants for GRB10 Gene

Sequence variations from dbSNP and Humsavar for GRB10 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs720845 -- 50,772,798(+) GACAC(C/T)ACGAA intron-variant
rs730652 -- 50,678,980(-) GTGGG(G/T)CAGCC intron-variant
rs734422 -- 50,755,733(+) AGAGA(C/T)GGGAG intron-variant
rs737292 -- 50,650,957(-) AGCTG(A/C)AAAAG intron-variant
rs740155 -- 50,755,409(+) TGACT(A/G)AGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRB10 Gene

Variant ID Type Subtype PubMed ID
nsv521070 CNV Loss 19592680
esv2734380 CNV Deletion 23290073
nsv5738 CNV Insertion 18451855
esv275051 CNV Loss 21479260
nsv824091 CNV Gain 20364138
nsv824092 CNV Gain 20364138
esv24304 CNV Loss 19812545

Relevant External Links for GRB10 Gene

HapMap Linkage Disequilibrium report
GRB10
Human Gene Mutation Database (HGMD)
GRB10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRB10 Gene

Disorders for GRB10 Gene

(2) University of Copenhagen DISEASES for GRB10 Gene

(4) Novoseek inferred disease relationships for GRB10 Gene

Disease -log(P) Hits PubMed IDs
growth retardation 28.5 1
metastasis 0 1
melanoma 0 1
cancer 0 1

Relevant External Links for GRB10

Genetic Association Database (GAD)
GRB10
Human Genome Epidemiology (HuGE) Navigator
GRB10
genes like me logo Genes that share disorders with GRB10: view

No data available for UniProtKB/Swiss-Prot for GRB10 Gene

Publications for GRB10 Gene

  1. Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling. (PMID: 8798417) O'Neill T.J. … Gustafson T.A. (J. Biol. Chem. 1996) 3 4 23
  2. Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases. (PMID: 9553107) Nantel A. … Thomas D.Y. (J. Biol. Chem. 1998) 3 4 23
  3. Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease. (PMID: 9881709) Angrist M. … Chakravarti A. (Oncogene 1998) 3 4 23
  4. Evidence against GRB10 as the gene responsible for Silver-Russell syndrome. (PMID: 11527390) McCann J.A. … Polychronakos C. (Biochem. Biophys. Res. Commun. 2001) 3 4 23
  5. Imprinting of human GRB10 and its mutations in two patients with Russell-Silver syndrome. (PMID: 10856193) Yoshihashi H. … Kosaki K. (Am. J. Hum. Genet. 2000) 3 4 23

Products for GRB10 Gene

  • Addgene plasmids for GRB10

Sources for GRB10 Gene

Back to Top

Content