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Aliases for GRB10 Gene

Aliases for GRB10 Gene

  • Growth Factor Receptor Bound Protein 10 2 3 5
  • Growth Factor Receptor-Bound Protein 10 2 3
  • Insulin Receptor-Binding Protein Grb-IR 3 4
  • GRB10 Adapter Protein 3 4
  • Maternally Expressed Gene 1 3
  • GRB10 Adaptor Protein 3
  • KIAA0207 4
  • GRB-IR 3
  • Grb-10 3
  • GRBIR 4
  • IRBP 3
  • MEG1 3
  • RSS 3

External Ids for GRB10 Gene

Previous GeneCards Identifiers for GRB10 Gene

  • GC07M050121
  • GC07M050365
  • GC07M050399
  • GC07M050431
  • GC07M050625
  • GC07M050657

Summaries for GRB10 Gene

Entrez Gene Summary for GRB10 Gene

  • The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]

GeneCards Summary for GRB10 Gene

GRB10 (Growth Factor Receptor Bound Protein 10) is a Protein Coding gene. Diseases associated with GRB10 include Silver-Russell Syndrome and Albright's Hereditary Osteodystrophy. Among its related pathways are RET signaling and Insulin Pathway. GO annotations related to this gene include SH3/SH2 adaptor activity and insulin receptor binding. An important paralog of this gene is GRB14.

UniProtKB/Swiss-Prot for GRB10 Gene

  • Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.

Gene Wiki entry for GRB10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRB10 Gene

Genomics for GRB10 Gene

Regulatory Elements for GRB10 Gene

Enhancers for GRB10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G050820 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.7 -28.6 -28574 2.8 PKNOX1 ATF1 FOXA2 MLX ARID4B SIN3A FEZF1 FOS DEK ZNF263 GRB10 ENSG00000228204 ENSG00000236046
GH07G050632 1.3 Ensembl ENCODE dbSUPER 15.9 +160.5 160528 1.3 SOX13 HDGF CTCF FOXA2 CBX3 TEAD4 CEBPG RAD21 TEAD3 CTBP1 GRB10 GC07M050654 DDC
GH07G050656 1.2 Ensembl ENCODE dbSUPER 16.1 +136.2 136182 2.5 CTCF MAX RAD21 YY1 NR2F2 JUND ATF3 ZSCAN5C HNF4A FOXP2 GRB10 GC07M050654 DDC
GH07G050837 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.7 -45.2 -45183 2.7 SOX5 SOX13 FOXA2 NR2F1 FOXA3 JUN BHLHE40 HLF CEBPB CEBPG GRB10 ENSG00000228204 ENSG00000236046
GH07G050661 1 Ensembl ENCODE dbSUPER 17.9 +131.3 131311 1.5 SREBF1 FOS EBF1 SPI1 GRB10 FIGNL1 PIR42465 GC07M050654
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GRB10 on UCSC Golden Path with GeneCards custom track

Promoters for GRB10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000212457 562 2201 ARNT SIN3A FEZF1 TCF12 ZNF263 ZNF592 MAFF ZNF610 SMARCA4 MYNN

Genomic Location for GRB10 Gene

Chromosome:
7
Start:
50,590,063 bp from pter
End:
50,793,462 bp from pter
Size:
203,400 bases
Orientation:
Minus strand

Genomic View for GRB10 Gene

Genes around GRB10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRB10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRB10 Gene

Proteins for GRB10 Gene

  • Protein details for GRB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13322-GRB10_HUMAN
    Recommended name:
    Growth factor receptor-bound protein 10
    Protein Accession:
    Q13322
    Secondary Accessions:
    • A4D258
    • A7VJ95
    • A8K0E6
    • D3DVM9
    • O00427
    • O00701
    • O75222
    • Q92606
    • Q92907
    • Q92948

    Protein attributes for GRB10 Gene

    Size:
    594 amino acids
    Molecular mass:
    67231 Da
    Quaternary structure:
    • Interacts with ligand-activated tyrosine kinase receptors, including FGFR1, INSR, IGF1R, MET and PDGFRB in a phosphotyrosine-dependent manner through the SH2 domain (By similarity). Poorly binds to the EGFR (By similarity). Directly interacts with MAP3K14/NIK and is recruited to the EGFR-ERBB2 complex. Interacts with GIGYF1/PERQ1 and GIGYF2/TNRC15 (By similarity). When unphosphorylated, interacts with AKT1 and when phosphorylated with YWHAE/14-3-3 epsilon. Interacts with NEDD4. Interacts with LRP6, thus interfering with the binding of AXIN1 to LRP6 (By similarity). Binds to activated NRAS.
    Miscellaneous:
    • GRB10 is unlikely to be responsible for Silver-Russell syndrome (SRS).
    • The GRB10 locus is imprinted. During embryonic development, the expression in the brain and spinal cord is from the paternal allele, while in placental villous trophoblasts and skeletal muscle, it is from the maternal one. Expression is biallelic in most other tissues. Paternal expression in the brain is maintained throughout adulthood. Imprinting often is isoform-specific.
    SequenceCaution:
    • Sequence=BAA13198.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GRB10 Gene

    Alternative splice isoforms for GRB10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRB10 Gene

Post-translational modifications for GRB10 Gene

  • Phosphorylated on serine residues upon EGF, FGF and PDGF stimulation (By similarity). Phosphorylated at Tyr-67 by TEC.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GRB10 (GRB10)
  • Cloud-Clone Corp. Antibodies for GRB10

No data available for DME Specific Peptides for GRB10 Gene

Domains & Families for GRB10 Gene

Suggested Antigen Peptide Sequences for GRB10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13322

UniProtKB/Swiss-Prot:

GRB10_HUMAN :
  • The PH domain binds relatively non-specifically to several phosphoinositides, including PI(5)P, PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3, with modest affinities.
  • Belongs to the GRB7/10/14 family.
Domain:
  • The PH domain binds relatively non-specifically to several phosphoinositides, including PI(5)P, PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3, with modest affinities.
Family:
  • Belongs to the GRB7/10/14 family.
genes like me logo Genes that share domains with GRB10: view

Function for GRB10 Gene

Molecular function for GRB10 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylation by mTORC1 stabilizes and activates GRB10 constituting a feedback pathway by which mTORC1 inhibits INSR-dependent signaling.
UniProtKB/Swiss-Prot Function:
Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.

Gene Ontology (GO) - Molecular Function for GRB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity IEA --
GO:0005158 insulin receptor binding ISS 15664450
GO:0005515 protein binding IPI 8798570
genes like me logo Genes that share ontologies with GRB10: view
genes like me logo Genes that share phenotypes with GRB10: view

Animal Models for GRB10 Gene

MGI Knock Outs for GRB10:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRB10 Gene

Localization for GRB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRB10 Gene

Cytoplasm. Note=When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRB10 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 3
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for GRB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9006901
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS 9006901
genes like me logo Genes that share ontologies with GRB10: view

Pathways & Interactions for GRB10 Gene

genes like me logo Genes that share pathways with GRB10: view

Pathways by source for GRB10 Gene

1 KEGG pathway for GRB10 Gene
1 GeneGo (Thomson Reuters) pathway for GRB10 Gene

SIGNOR curated interactions for GRB10 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for GRB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007411 axon guidance TAS --
GO:0030178 negative regulation of Wnt signaling pathway IDA 17376403
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IDA 15060076
GO:0042326 negative regulation of phosphorylation IEA --
genes like me logo Genes that share ontologies with GRB10: view

Drugs & Compounds for GRB10 Gene

(1) Drugs for GRB10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for GRB10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GRB10: view

Transcripts for GRB10 Gene

Unigene Clusters for GRB10 Gene

Growth factor receptor-bound protein 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRB10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^
SP1: - - - - - - - - - - - -
SP2: - - - - -
SP3:
SP4: - - -
SP5: - - - - - - - - - - - - - - - - - -
SP6:
SP7: - - - - - - - - - - - - - - - -
SP8:
SP9: - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - -
SP12: - - -
SP13:
SP14: -
SP15: - - - - - - - - - -
SP16: - - - -
SP17:
SP18:

ExUns: 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b · 24c ^ 25a · 25b
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5:
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for GRB10 Gene

GeneLoc Exon Structure for
GRB10
ECgene alternative splicing isoforms for
GRB10

Expression for GRB10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRB10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GRB10 Gene

This gene is overexpressed in Pancreas (45.8), Gallbladder (12.1), and Retina (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GRB10 Gene



Protein tissue co-expression partners for GRB10 Gene

NURSA nuclear receptor signaling pathways regulating expression of GRB10 Gene:

GRB10

SOURCE GeneReport for Unigene cluster for GRB10 Gene:

Hs.164060

mRNA Expression by UniProt/SwissProt for GRB10 Gene:

Q13322-GRB10_HUMAN
Tissue specificity: Widely expressed in fetal and adult tissues, including fetal and postnatal liver, lung, kidney, skeletal muscle, heart, spleen, skin and brain.

Evidence on tissue expression from TISSUES for GRB10 Gene

  • Nervous system(4.8)
  • Kidney(4.4)
  • Muscle(4.4)
  • Bone marrow(4.2)
  • Pancreas(2.3)
genes like me logo Genes that share expression patterns with GRB10: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRB10 Gene

Orthologs for GRB10 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRB10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRB10 34 35
  • 99.94 (n)
cow
(Bos Taurus)
Mammalia GRB10 34 35
  • 88.89 (n)
oppossum
(Monodelphis domestica)
Mammalia GRB10 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRB10 35
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRB10 34 35
  • 84.89 (n)
rat
(Rattus norvegicus)
Mammalia Grb10 34
  • 83.26 (n)
mouse
(Mus musculus)
Mammalia Grb10 34 16 35
  • 81.36 (n)
chicken
(Gallus gallus)
Aves GRB10 34 35
  • 79.28 (n)
lizard
(Anolis carolinensis)
Reptilia GRB10 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grb10 34
  • 74.58 (n)
Str.10026 34
zebrafish
(Danio rerio)
Actinopterygii grb10b 34 35
  • 72.21 (n)
grb10a 35
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta pico 35
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mig-10 35
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10684 35
  • 36 (a)
OneToMany
Species where no ortholog for GRB10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRB10 Gene

ENSEMBL:
Gene Tree for GRB10 (if available)
TreeFam:
Gene Tree for GRB10 (if available)

Paralogs for GRB10 Gene

Paralogs for GRB10 Gene

(3) SIMAP similar genes for GRB10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GRB10: view

Variants for GRB10 Gene

Sequence variations from dbSNP and Humsavar for GRB10 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000001901 -- 50,665,156(+) ATACA(C/T)CACGG intron-variant, upstream-variant-2KB
rs1000006449 -- 50,679,968(+) TATTC(G/T)CATGT intron-variant
rs1000008978 -- 50,628,035(+) CATAC(A/G)ACAAG intron-variant
rs1000011560 -- 50,775,206(+) ACAGA(-/CATT)CATTC intron-variant
rs1000019624 -- 50,704,242(+) ACACA(C/T)GCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRB10 Gene

Variant ID Type Subtype PubMed ID
dgv6347n100 CNV loss 25217958
esv24304 CNV loss 19812545
esv2734380 CNV deletion 23290073
esv275051 CNV loss 21479260
esv3613129 CNV loss 21293372
nsv1015758 CNV gain 25217958
nsv1016665 CNV gain 25217958
nsv1132054 CNV deletion 24896259
nsv1137576 CNV deletion 24896259
nsv476821 CNV novel sequence insertion 20440878
nsv521070 CNV loss 19592680
nsv5738 CNV insertion 18451855
nsv606906 CNV loss 21841781
nsv824091 CNV gain 20364138
nsv824092 CNV gain 20364138

Variation tolerance for GRB10 Gene

Residual Variation Intolerance Score: 13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRB10 Gene

Human Gene Mutation Database (HGMD)
GRB10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRB10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRB10 Gene

Disorders for GRB10 Gene

MalaCards: The human disease database

(5) MalaCards diseases for GRB10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
silver-russell syndrome
  • srs
albright's hereditary osteodystrophy
  • albright hereditary osteodystrophy
silver spastic paraplegia syndrome
  • neuronopathy, distal hereditary motor, type vb
adult syndrome
  • acro-dermato-ungual-lacrimal-tooth syndrome
diabetes mellitus, transient neonatal, 1
  • diabetes mellitus, transient neonatal
- elite association - COSMIC cancer census association via MalaCards
Search GRB10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GRB10

Genetic Association Database (GAD)
GRB10
Human Genome Epidemiology (HuGE) Navigator
GRB10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRB10
genes like me logo Genes that share disorders with GRB10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRB10 Gene

Publications for GRB10 Gene

  1. Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression. (PMID: 19487367) Monk D. … Moore G.E. (Hum. Mol. Genet. 2009) 3 4 22 64
  2. Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14. (PMID: 19648926) Depetris R.S. … Hubbard S.R. (Nat. Struct. Mol. Biol. 2009) 3 4 22 64
  3. GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway. (PMID: 17376403) Tezuka N. … Yanagawa S. (Biochem. Biophys. Res. Commun. 2007) 3 4 22 64
  4. Grb10 mediates insulin-stimulated degradation of the insulin receptor: a mechanism of negative regulation. (PMID: 16434550) Ramos F.J. … Liu F. (Am. J. Physiol. 2006) 3 4 22 64
  5. Phosphorylation of Grb10 by mitogen-activated protein kinase: identification of Ser150 and Ser476 of human Grb10zeta as major phosphorylation sites. (PMID: 15952796) Langlais P. … Liu F. (Biochemistry 2005) 3 4 22 64

Products for GRB10 Gene

Sources for GRB10 Gene

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