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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GRB10 Gene

protein-coding GIFtS: 63
GCID: GC07M050625

growth factor receptor-bound protein 10

Explore 18 diseases affiliated with
GRB10 via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Growth Factor Receptor-Bound Protein 10¹ ²		IRBP²
Insulin Receptor-Binding Protein Grb-IR² ³		MEG1²
GRB10 Adapter Protein² ³		GRB10 Adaptor Protein²
RSS² ⁵		Maternally Expressed Gene 1²
GRB-IR²		GRBIR³
Grb-10²		KIAA0207³

External Ids:	HGNC: 4564¹	Entrez Gene: 2887²	Ensembl: ENSG00000106070⁷	OMIM: 601523⁵	UniProtKB: Q13322³

Export aliases for GRB10 gene to outside databases

Previous GC identifers: GC07M050121 GC07M050365 GC07M050399 GC07M050431

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GRB10:

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of

receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that

interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the

encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a

highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from

the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different

isoforms have been identified. (provided by RefSeq, Oct 2010)

UniProtKB/Swiss-Prot: GRB10_HUMAN, Q13322

Function: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling

pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and

insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with

the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to

insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2

tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and

degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated

ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with

LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2

signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2

Gene Wiki entry for GRB10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_033968.6 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GRB10 gene promoter:
Bach1 Elk-1 Meis-1b c-Ets-1 PPAR-alpha POU2F1 POU2F1a c-Myb Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 9): GRB10 promoter sequence

Search SABiosciences Chromatin IP Primers for GRB10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRB10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p12.2 Ensembl cytogenetic band: 7p12.1 HGNC cytogenetic band: 7p12.2

GRB10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRB10 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M050625: view genomic region (about GC identifiers)

Start:	50,657,760 bp from pter	End:	50,861,159 bp from pter
Size:	203,400 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 50,663,826-50,867,195

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GRB10_HUMAN, Q13322 (See protein sequence)

Recommended Name: Growth factor receptor-bound protein 10

Size: 594 amino acids; 67231 Da

Subunit: Interacts with ligand-activated tyrosine kinase receptors, including FGFR1, INSR, IGF1R, MET and PDGFRB in a

phosphotyrosine-dependent manner through the SH2 domain (By similarity). Poorly binds to the EGFR (By similarity).

Directly interacts with MAP3K14/NIK and is recruited to the EGFR-ERBB2 complex. Interacts with GIGYF1/PERQ1 and

GIGYF2/TNRC15 (By similarity). When unphosphorylated, interacts with AKT1 and when phosphorylated with YWHAE/14-3-3

epsilon. Interacts with NEDD4. Interacts with LRP6, thus interfering with the binding of AXIN1 to LRP6 (By

similarity). Binds to activated NRAS

Subcellular location: Cytoplasm (By similarity). Note=When complexed with NEDD4 and IGF1R, follows IGF1R

internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the

sorting of the receptor to the lysosomal compartment (By similarity)

Miscellaneous: The GRB10 locus is imprinted. During embryonic development, the expression in the brain and spinal cord

is from the paternal allele, while in placental villous trophoblasts and skeletal muscle, it is from the maternal one.

Expression is biallelic in most other tissues. Paternal expression in the brain is maintained throughout adulthood.

Imprinting often is isoform-specific

Miscellaneous: GRB10 is unlikely to be responsible for Silver-Russell syndrome (SRS)

Sequence caution: Sequence=BAA13198.2; Type=Erroneous initiation;

2 PDB 3D structures from and Proteopedia for GRB10:

1NRV (3D)

3HK0 (3D)

Secondary accessions: A4D258 A7VJ95 A8K0E6 D3DVM9 O00427 O00701 O75222 Q92606 Q92907 Q92948

Alternative splicing: 4 isoforms: Q13322-1 Q13322-2 Q13322-3 Q13322-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GRB10: NX_Q13322

Post-translational modifications:

Phosphorylated on serine residues upon EGF, FGF and PDGF stimulation (By similarity). Phosphorylated at Tyr-67 by TEC¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13322

GRB10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001001549.1 NP_001001550.1 NP_001001555.1 NP_005302.3

ENSEMBL proteins:

ENSP00000385189 ENSP00000385544 ENSP00000385366 ENSP00000349818 ENSP00000385046

ENSP00000385770 ENSP00000385748 ENSP00000410920 ENSP00000413023 ENSP00000381793

ENSP00000406716 ENSP00000338543 ENSP00000381790

Reactome Protein details: Q13322
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): GRB10 OriGene Protein Over-expression Lysate (see all 3): GRB10 OriGene Custom Protein Services for GRB10
	GenScript Custom Purified and Recombinant Proteins Services for GRB10
	Novus Biologicals GRB10 Proteins Novus Biologicals GRB10 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	9006901
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	TAS	9006901

GRB10 for ontologies About GeneDecksing

GRB10 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of GRB10
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for GRB10
	Browse OriGene Antibodies OriGene Custom Antibody Services for GRB10
	GenScript Custom Superior Antibodies Services for GRB10
	Novus Biologicals GRB10 Antibodies
	Search for Antibodies for GRB10 at Abcam
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for GRB10

Assay Products for GRB10:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for GRB10
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GRB10 for domains About GeneDecksing

5 InterPro domains/families:

IPR001849 Pleckstrin_homology

IPR011993 PH_like_dom

IPR000159 Ras-assoc

IPR015042 BPS-dom

IPR000980 SH2

Graphical View of Domain Structure for InterPro Entry Q13322

ProtoNet protein and cluster: Q13322

3 Blocks protein families:

IPB000159 RA domain

IPB000980 SH2 domain signature

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: GRB10_HUMAN, Q13322

Domain: The PH domain binds relatively non-specifically to several phosphoinositides, including PI(5)P, PI(4,5)P2,

PI(3,4)P2 and PI(3,4,5)P3, with modest affinities

Similarity: Belongs to the GRB7/10/14 family

Similarity: Contains 1 PH domain

Similarity: Contains 1 Ras-associating domain

Similarity: Contains 1 SH2 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary: