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Aliases for GRASP Gene

Aliases for GRASP Gene

  • General Receptor For Phosphoinositides 1 Associated Scaffold Protein 2 3 5
  • GRP1 (General Receptor For Phosphoinositides 1)-Associated Scaffold Protein 2 3
  • General Receptor For Phosphoinositides 1-Associated Scaffold Protein 3
  • GRP1-Associated Scaffold Protein 4
  • TAMALIN 3

External Ids for GRASP Gene

Previous GeneCards Identifiers for GRASP Gene

  • GC12U990153
  • GC12P052431
  • GC12P052117
  • GC12P050687
  • GC12P049435
  • GC12P052400

Summaries for GRASP Gene

Entrez Gene Summary for GRASP Gene

  • This gene encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins. The encoded protein contains conserved domains, including a leucine zipper sequence, PDZ domain and a C-terminal PDZ-binding motif. Alternately spliced transcript variants have been observed for this gene.[provided by RefSeq, Dec 2012]

GeneCards Summary for GRASP Gene

GRASP (General Receptor For Phosphoinositides 1 Associated Scaffold Protein) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and ADP-ribosylation factor binding. An important paralog of this gene is CYTIP.

UniProtKB/Swiss-Prot for GRASP Gene

  • Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses.

Additional gene information for GRASP Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRASP Gene

Genomics for GRASP Gene

Regulatory Elements for GRASP Gene

Enhancers for GRASP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H051969 2 FANTOM5 Ensembl ENCODE dbSUPER 14.3 -34.3 -34345 5.2 PKNOX1 FOXA2 ARNT ZNF2 YY1 ZNF766 ZNF143 FOS JUNB REST NR4A1 HNRNPA3P10 GRASP ATG101 ACVR1B ACVRL1 ANKRD33 SMAGP GC12P051989
GH12H051975 1.4 Ensembl ENCODE dbSUPER 12.4 -29.9 -29888 2.5 HDAC1 ELF3 ATF1 ARID4B THRB RAD21 RARA GATA2 ATF7 CREM ACVR1B GRASP NR4A1 ACVRL1 ANKRD33 ENSG00000260473 GC12P051989
GH12H052078 1.5 Ensembl ENCODE dbSUPER 11.4 +74.4 74414 5 HDGF PKNOX1 ARID4B GLIS2 ZNF143 RUNX3 DEK SP5 REST ZNF592 NR4A1 GRASP OR7E47P ENSG00000257989 EIF4B KRT6C ENSG00000257663
GH12H051980 1 ENCODE dbSUPER 12.4 -26.4 -26426 0.2 HDGF CTCF RB1 ARID4B MAX RAD21 RFX5 CC2D1A ZFHX2 CTBP1 GRASP NR4A1 ACVRL1 ANKRD33 ACVR1B GC12P051989
GH12H051855 1.2 FANTOM5 Ensembl ENCODE 10.3 -150.8 -150838 1.3 SOX13 TBP CEBPB REST TEAD3 POLR2A HNF4A KDM1A PRDM10 ZNF600 ANKRD33 SLC4A8 NR4A1 GRASP GALNT6 FIGNL2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GRASP on UCSC Golden Path with GeneCards custom track

Promoters for GRASP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000051975 463 1601 POLR2A CEBPB SIN3A SPI1 NR2F2 EZH2

Genomic Locations for GRASP Gene

Genomic Locations for GRASP Gene
chr12:52,006,937-52,015,889
(GRCh38/hg38)
Size:
8,953 bases
Orientation:
Plus strand
chr12:52,400,724-52,409,673
(GRCh37/hg19)

Genomic View for GRASP Gene

Genes around GRASP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRASP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRASP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRASP Gene

Proteins for GRASP Gene

  • Protein details for GRASP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6J2-GRASP_HUMAN
    Recommended name:
    General receptor for phosphoinositides 1-associated scaffold protein
    Protein Accession:
    Q7Z6J2
    Secondary Accessions:
    • Q6PIF8
    • Q7Z741

    Protein attributes for GRASP Gene

    Size:
    395 amino acids
    Molecular mass:
    42623 Da
    Quaternary structure:
    • Heteromer. Composed of GRASP, PSCD2 and at least one GRM1. Also interacts with PSCD3, GRM2, GRM3 and GRM5 (By similarity).

    Three dimensional structures from OCA and Proteopedia for GRASP Gene

    Alternative splice isoforms for GRASP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRASP Gene

Post-translational modifications for GRASP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GRASP Gene

No data available for DME Specific Peptides for GRASP Gene

Domains & Families for GRASP Gene

Gene Families for GRASP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GRASP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GRASP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GRASP: view

No data available for UniProtKB/Swiss-Prot for GRASP Gene

Function for GRASP Gene

Molecular function for GRASP Gene

UniProtKB/Swiss-Prot Function:
Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses.

Phenotypes From GWAS Catalog for GRASP Gene

Gene Ontology (GO) - Molecular Function for GRASP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030165 PDZ domain binding IEA --
GO:0030306 ADP-ribosylation factor binding IEA --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with GRASP: view
genes like me logo Genes that share phenotypes with GRASP: view

Animal Models for GRASP Gene

MGI Knock Outs for GRASP:

Animal Model Products

Clone Products

  • Addgene plasmids for GRASP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRASP Gene

Localization for GRASP Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRASP Gene

Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane. Note=Localized at postsynaptic membranes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRASP gene
Compartment Confidence
plasma membrane 4
nucleus 2
cytosol 2
golgi apparatus 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GRASP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
GO:0045202 synapse IEA --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with GRASP: view

Pathways & Interactions for GRASP Gene

SuperPathways for GRASP Gene

No Data Available

Gene Ontology (GO) - Biological Process for GRASP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0008104 protein localization IEA --
genes like me logo Genes that share ontologies with GRASP: view

No data available for Pathways by source and SIGNOR curated interactions for GRASP Gene

Drugs & Compounds for GRASP Gene

No Compound Related Data Available

Transcripts for GRASP Gene

Unigene Clusters for GRASP Gene

GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein:
Representative Sequences:

Clone Products

  • Addgene plasmids for GRASP

Alternative Splicing Database (ASD) splice patterns (SP) for GRASP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: -
SP3:

Relevant External Links for GRASP Gene

GeneLoc Exon Structure for
GRASP
ECgene alternative splicing isoforms for
GRASP

Expression for GRASP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRASP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GRASP Gene

This gene is overexpressed in Cerebrospinal fluid (58.3) and Platelet (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRASP Gene



Protein tissue co-expression partners for GRASP Gene

NURSA nuclear receptor signaling pathways regulating expression of GRASP Gene:

GRASP

SOURCE GeneReport for Unigene cluster for GRASP Gene:

Hs.407202

Evidence on tissue expression from TISSUES for GRASP Gene

  • Skin(4.1)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with GRASP: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRASP Gene

Orthologs for GRASP Gene

This gene was present in the common ancestor of animals.

Orthologs for GRASP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRASP 34 33
  • 99.54 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GRASP 33 34
  • 88.03 (n)
rat
(Rattus norvegicus)
Mammalia Grasp 33
  • 86.38 (n)
mouse
(Mus musculus)
Mammalia Grasp 33 16 34
  • 86.05 (n)
oppossum
(Monodelphis domestica)
Mammalia GRASP 34
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRASP 34
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRASP 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grasp 33
  • 59.48 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC52824 33
zebrafish
(Danio rerio)
Actinopterygii grasp 33 34
  • 56.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6619 34
  • 7 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gras-1 34
  • 20 (a)
OneToMany
Species where no ortholog for GRASP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRASP Gene

ENSEMBL:
Gene Tree for GRASP (if available)
TreeFam:
Gene Tree for GRASP (if available)

Paralogs for GRASP Gene

Paralogs for GRASP Gene

(1) SIMAP similar genes for GRASP Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GRASP: view

Variants for GRASP Gene

Sequence variations from dbSNP and Humsavar for GRASP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs200789033 Likely benign 52,015,095(+) TATGC(A/G/T)GCCCC reference, missense
rs1000183216 -- 52,009,771(+) CCACA(C/G)TTTCC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000525479 -- 52,008,168(+) GGAAC(C/T)GTCCC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000527770 -- 52,015,510(+) ACACC(C/T)TCCCA utr-variant-3-prime
rs1000719644 -- 52,008,556(+) CAGCT(-/G)GTCAC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GRASP Gene

Variant ID Type Subtype PubMed ID
nsv558898 CNV loss 21841781
nsv469378 CNV loss 19166990
dgv2629n54 CNV loss 21841781

Variation tolerance for GRASP Gene

Residual Variation Intolerance Score: 45.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRASP Gene

Human Gene Mutation Database (HGMD)
GRASP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRASP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRASP Gene

Disorders for GRASP Gene

Relevant External Links for GRASP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRASP

No disorders were found for GRASP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRASP Gene

Publications for GRASP Gene

  1. GRASP and IPCEF promote ARF-to-Rac signaling and cell migration by coordinating the association of ARNO/cytohesin 2 with Dock180. (PMID: 20016009) White DT … Santy LC (Molecular biology of the cell 2010) 3 22 60
  2. Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation. (PMID: 17396155) Sugi T … Jingami H (The EMBO journal 2007) 3 22 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors. (PMID: 10828067) Nevrivy DJ … Leid M (The Journal of biological chemistry 2000) 2 3 60
  5. Metabotropic glutamate receptor 5, and its trafficking molecules Norbin and Tamalin, are increased in the CA1 hippocampal region of subjects with schizophrenia. (PMID: 26048293) Matosin N … Newell KA (Schizophrenia research 2015) 3 60

Products for GRASP Gene

  • Addgene plasmids for GRASP

Sources for GRASP Gene

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