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Aliases for GRASP Gene

Aliases for GRASP Gene

  • GRP1 (General Receptor For Phosphoinositides 1)-Associated Scaffold Protein 2 3 5
  • GRP1-Associated Scaffold Protein 3 4
  • TAMALIN 3

External Ids for GRASP Gene

Previous GeneCards Identifiers for GRASP Gene

  • GC12U990153
  • GC12P052431
  • GC12P052117
  • GC12P050687
  • GC12P049435
  • GC12P052400

Summaries for GRASP Gene

Entrez Gene Summary for GRASP Gene

  • This gene encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins. The encoded protein contains conserved domains, including a leucine zipper sequence, PDZ domain and a C-terminal PDZ-binding motif. Alternately spliced transcript variants have been observed for this gene.[provided by RefSeq, Dec 2012]

GeneCards Summary for GRASP Gene

GRASP (GRP1 (General Receptor For Phosphoinositides 1)-Associated Scaffold Protein) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and ADP-ribosylation factor binding. An important paralog of this gene is CYTIP.

UniProtKB/Swiss-Prot for GRASP Gene

  • Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRASP Gene

Genomics for GRASP Gene

Regulatory Elements for GRASP Gene

Enhancers for GRASP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GRASP on UCSC Golden Path with GeneCards custom track

Promoters for GRASP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GRASP on UCSC Golden Path with GeneCards custom track

Genomic Location for GRASP Gene

Chromosome:
12
Start:
52,006,937 bp from pter
End:
52,015,889 bp from pter
Size:
8,953 bases
Orientation:
Plus strand

Genomic View for GRASP Gene

Genes around GRASP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRASP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRASP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRASP Gene

Proteins for GRASP Gene

  • Protein details for GRASP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6J2-GRASP_HUMAN
    Recommended name:
    General receptor for phosphoinositides 1-associated scaffold protein
    Protein Accession:
    Q7Z6J2
    Secondary Accessions:
    • Q6PIF8
    • Q7Z741

    Protein attributes for GRASP Gene

    Size:
    395 amino acids
    Molecular mass:
    42623 Da
    Quaternary structure:
    • Heteromer. Composed of GRASP, PSCD2 and at least one GRM1. Also interacts with PSCD3, GRM2, GRM3 and GRM5 (By similarity).

    Three dimensional structures from OCA and Proteopedia for GRASP Gene

    Alternative splice isoforms for GRASP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRASP Gene

Proteomics data for GRASP Gene at MOPED

Post-translational modifications for GRASP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GRASP Gene

No data available for DME Specific Peptides for GRASP Gene

Domains & Families for GRASP Gene

Gene Families for GRASP Gene

Protein Domains for GRASP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GRASP Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z6J2

UniProtKB/Swiss-Prot:

GRASP_HUMAN :
  • Contains 1 PDZ (DHR) domain.
Domain:
  • Contains 1 PDZ (DHR) domain.
genes like me logo Genes that share domains with GRASP: view

Function for GRASP Gene

Molecular function for GRASP Gene

UniProtKB/Swiss-Prot Function:
Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses.
genes like me logo Genes that share phenotypes with GRASP: view

Animal Models for GRASP Gene

MGI Knock Outs for GRASP:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRASP Gene

Localization for GRASP Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRASP Gene

Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane. Note=Localized at postsynaptic membranes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRASP Gene COMPARTMENTS Subcellular localization image for GRASP gene
Compartment Confidence
plasma membrane 4
cytosol 2
golgi apparatus 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GRASP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with GRASP: view

Pathways & Interactions for GRASP Gene

SuperPathways for GRASP Gene

No Data Available

Gene Ontology (GO) - Biological Process for GRASP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GRASP Gene

Drugs & Compounds for GRASP Gene

No Compound Related Data Available

Transcripts for GRASP Gene

mRNA/cDNA for GRASP Gene

(5) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRASP Gene

GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRASP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: -
SP3:

Relevant External Links for GRASP Gene

GeneLoc Exon Structure for
GRASP
ECgene alternative splicing isoforms for
GRASP

Expression for GRASP Gene

mRNA expression in normal human tissues for GRASP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GRASP Gene

This gene is overexpressed in Cerebrospinal fluid (58.3) and Platelet (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRASP Gene



SOURCE GeneReport for Unigene cluster for GRASP Gene Hs.407202

genes like me logo Genes that share expression patterns with GRASP: view

Protein tissue co-expression partners for GRASP Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GRASP Gene

Orthologs for GRASP Gene

This gene was present in the common ancestor of animals.

Orthologs for GRASP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GRASP 35
  • 88.03 (n)
  • 89.74 (a)
GRASP 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grasp 35
  • 86.05 (n)
  • 89.54 (a)
Grasp 16
Grasp 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GRASP 35
  • 99.54 (n)
  • 99.32 (a)
GRASP 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grasp 35
  • 86.38 (n)
  • 90.36 (a)
dog
(Canis familiaris)
Mammalia GRASP 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRASP 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRASP 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grasp 35
  • 59.48 (n)
  • 59.2 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC52824 35
zebrafish
(Danio rerio)
Actinopterygii grasp 35
  • 56.67 (n)
  • 53.12 (a)
grasp 36
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6619 36
  • 7 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gras-1 36
  • 20 (a)
OneToMany
Species with no ortholog for GRASP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRASP Gene

ENSEMBL:
Gene Tree for GRASP (if available)
TreeFam:
Gene Tree for GRASP (if available)

Paralogs for GRASP Gene

Paralogs for GRASP Gene

(1) SIMAP similar genes for GRASP Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GRASP: view

Variants for GRASP Gene

Sequence variations from dbSNP and Humsavar for GRASP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7137072 -- 52,014,683(+) TCCCG(A/T)CTCTG intron-variant
rs12822182 -- 52,006,830(+) GCCTC(A/G)CGGGG upstream-variant-2KB
rs10876227 -- 52,009,326(+) CTAGC(A/G)AGGGT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs17126240 -- 52,005,880(+) CTGCT(G/T)CTTGG upstream-variant-2KB
rs7316372 -- 52,011,829(+) GCAGC(C/G)TGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRASP Gene

Variant ID Type Subtype PubMed ID
nsv899079 CNV Loss 21882294
dgv1424n71 CNV Loss 21882294
nsv469378 CNV Loss 19166990

Variation tolerance for GRASP Gene

Residual Variation Intolerance Score: 45.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRASP Gene

Human Gene Mutation Database (HGMD)
GRASP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRASP Gene

Disorders for GRASP Gene

Relevant External Links for GRASP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRASP

No disorders were found for GRASP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRASP Gene

Publications for GRASP Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. GRASP and IPCEF promote ARF-to-Rac signaling and cell migration by coordinating the association of ARNO/cytohesin 2 with Dock180. (PMID: 20016009) White D.T. … Santy L.C. (Mol. Biol. Cell 2010) 3 23
  3. Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation. (PMID: 17396155) Sugi T. … Jingami H. (EMBO J. 2007) 3 23
  4. Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors. (PMID: 10828067) Nevrivy D.J. … Leid M. (J. Biol. Chem. 2000) 2 3
  5. Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment. (PMID: 24939585) Fransen E. … Friedman R.A. (Eur. J. Hum. Genet. 2015) 3

Products for GRASP Gene

Sources for GRASP Gene

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