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GRAPL Gene

protein-coding   GIFtS: 37
GCID: GC17P019030

GRB2-Related Adaptor Protein-Like

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
GRB2-Related Adaptor Protein-Like1 2
GRB2-Related Adapter Protein LOC4005812
GRB2-Related Adapter Protein-Like2

External Ids:    HGNC: 372401   Entrez Gene: 4005812   Ensembl: ENSG000001891527   UniProtKB: Q8TC173   

Export aliases for GRAPL gene to outside databases

Previous GC identifer: GC17P018972


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GRAPL Gene:
GRAPL (GRB2-related adaptor protein-like) is a protein-coding gene. An important paralog of this gene is GRAP.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for GRAPL
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for GRAPL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRAPL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

GRAPL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRAPL gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P019030:  view genomic region     (about GC identifiers)

Start:
19,030,782 bp from pter      End:
19,062,489 bp from pter
Size:
31,708 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GRAPL_HUMAN, Q8TC17 (See protein sequence)
Recommended Name: GRB2-related adapter protein-like  
Size: 118 amino acids; 13442 Da
Secondary accessions: B2RXI8
Alternative splicing: 2 isoforms:  Q8TC17-1   Q8TC17-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GRAPL: NX_Q8TC17

Explore proteomics data for GRAPL at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys38

  • See GRAPL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001123250.1  
    ENSEMBL proteins: 
     ENSP00000437409   ENSP00000466091   ENSP00000465788   ENSP00000459618   ENSP00000464934  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    2 InterPro protein domains:
     IPR001452 SH3_domain
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q8TC17

    ProtoNet protein and cluster: Q8TC17

    UniProtKB/Swiss-Prot: GRAPL_HUMAN, Q8TC17
    Similarity: Belongs to the GRB2/sem-5/DRK family
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with GRAPL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with GRAPL           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    extracellular1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GRAPL
    Interactions:

        Search GeneGlobe Interaction Network for GRAPL

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GRAPL



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GRAPL gene: 
    NM_001129778.1  

    Unigene Cluster for GRAPL:

    GRB2-related adaptor protein-like
    Hs.661470  [show with all ESTs]
    Unigene Representative Sequence: BC060883
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344415(uc010cqk.1) ENST00000577213 ENST00000437957 ENST00000574324
    ENST00000583540
    miRNA
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    hsa-miR-345 hsa-miR-1207-3p
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK000842.1 BC060883.1 

    2 DOTS entries:

    DT.108652  DT.120923553 

    3 AceView cDNA sequences:

    BG541579 BC026233 BX405191 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for GRAPL    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for GRAPL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GRAPL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGATGACC
    GRAPL Expression
    About this image

    GRAPL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GRAPL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.661470
        Custom PCR Arrays for GRAPL
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GRAPL gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia GRAPL6
    GRB2-related adaptor protein-like
    39(a)
    1 ↔ 1
    5(41014076-41040385)
    chicken
    (Gallus gallus)
    Aves GRAP6
    Gallus gallus GRB2-related adaptor protein (GRAP),...
    40(a)
    1 → many
    14(5158279-5162171)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    38(a)
    1 → many
    GL343618.1(349579-368900)
    zebrafish
    (Danio rerio)
    Actinopterygii grapb6
    grapa6
    GRB2-related adaptor protein a
    33(a)
    32(a)
    many ↔ many
    many ↔ many
    1(7192320-7219398) ENSDARG00000022668
    3(39625712-39642803) ENSDARG00000005414
    fruit fly
    (Drosophila melanogaster)
    Insecta drk6
    downstream of receptor kinase
    31(a)
    1 → many
    2R(9382727-9390342)
    worm
    (Caenorhabditis elegans)
    Secernentea sem-56
    Protein SEM-5 (sem-5) mRNA, complete cds
    27(a)
    1 → many
    X(7959827-7961725) WBGene00004774


    ENSEMBL Gene Tree for GRAPL (if available)
    TreeFam Gene Tree for GRAPL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GRAPL gene
    GRAP2  NCK12  NCK22  GRAP22  GRB22  
    Selected SIMAP similar genes for GRAPL using alignment to 5 protein entries:     GRAPL_HUMAN (see all proteins) (see all similar genes):
    GRAP    GRB2    ITSN1    SH3RF3    GRAP2    ARHGEF7
    CRK    SH3RF1    ITSN2    ABL1    YES1    SH3GL1
    BCR/ABL fusion    BTK    HCK    FYN    LCK    SH3GL2

    Find genes that share paralogs with GRAPL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    10 SNPs for GRAPL    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2017831141,2
    --19042674(+) AGACA-/TGGGTC 1 -- int10--------
    rs2003817081,2
    --19042675(+) GACAG-/TGGTCA 1 -- int10--------
    rs1855864021,2
    C--19045947(+) GAGCCA/CTTGAC 1 -- int10--------
    rs3687717401,2
    C--19050505(+) AGTGGC/TATCCT 1 -- int10--------
    rs3745278271,2
    ----19049849(+) TACTCA/GGAAGG 1 -- int10--------
    rs3756539041,2
    ----19050330(+) GTAGG-/GTTGTGT 1 -- int10--------
    rs2021839001,2
    ----19050364(+) TGTGT-/GCG   
       CGCGC
    GCGCG
    1 -- int10--------
    rs2015785071,2
    ----19050363(+) GTGTGC/TGCGCG 1 -- int10--------
    rs2000375971,2
    ----19050909(+) GGGGGC/GCACAG 1 -- int10--------
    rs3777520251,2
    ----19034362(+) AGAGTA/GTGCCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for GRAPL (19030782 - 19062489 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GRAPL (see all 34):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3090n71CNV Loss21882294
    nsv907844CNV Loss21882294
    nsv907825CNV Loss21882294
    nsv2001CNV Loss18451855
    dgv3082n71CNV Loss21882294
    dgv3083n71CNV Loss21882294
    dgv3088n71CNV Loss21882294
    dgv3098n71CNV Loss21882294
    nsv833391CNV Loss17160897
    dgv3094n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GRAPL gene integrated from 10 sources:
    (articles sorted by number of sources associating them with GRAPL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Identification of differential protein expression associated with development of unstable human carotid plaques. (PubMed id 16507914)9 Slevin M....Gaffney J. (Am. J. Pathol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 400581 HGNC: 37240 AceView: LOC400581 Ensembl:ENSG00000189152 euGenes: HUgn400581
    ECgene: GRAPL H-InvDB: GRAPL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GRAPL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GRAPL gene:
    Search GeneIP for patents involving GRAPL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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