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Aliases for GRAPL Gene

Aliases for GRAPL Gene

  • GRB2-Related Adaptor Protein-Like 2 3 5

External Ids for GRAPL Gene

Previous GeneCards Identifiers for GRAPL Gene

  • GC17P018972
  • GC17P019030

Summaries for GRAPL Gene

GeneCards Summary for GRAPL Gene

GRAPL (GRB2-Related Adaptor Protein-Like) is a Protein Coding gene. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Signaling by GPCR. An important paralog of this gene is NCK1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRAPL Gene

Genomics for GRAPL Gene

Regulatory Elements for GRAPL Gene

Enhancers for GRAPL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GRAPL on UCSC Golden Path with GeneCards custom track

Promoters for GRAPL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GRAPL on UCSC Golden Path with GeneCards custom track

Genomic Location for GRAPL Gene

19,127,469 bp from pter
19,159,176 bp from pter
31,708 bases
Plus strand

Genomic View for GRAPL Gene

Genes around GRAPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRAPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRAPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRAPL Gene

Proteins for GRAPL Gene

  • Protein details for GRAPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GRB2-related adapter protein-like
    Protein Accession:
    Secondary Accessions:
    • B2RXI8

    Protein attributes for GRAPL Gene

    118 amino acids
    Molecular mass:
    13442 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GRAPL Gene


neXtProt entry for GRAPL Gene

Proteomics data for GRAPL Gene at MOPED

Post-translational modifications for GRAPL Gene

No Post-translational modifications

Other Protein References for GRAPL Gene

No data available for DME Specific Peptides for GRAPL Gene

Domains & Families for GRAPL Gene

Gene Families for GRAPL Gene

Protein Domains for GRAPL Gene


Suggested Antigen Peptide Sequences for GRAPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SH2 domain.
  • Belongs to the GRB2/sem-5/DRK family.
  • Contains 1 SH2 domain.
  • Contains 1 SH3 domain.
  • Belongs to the GRB2/sem-5/DRK family.
genes like me logo Genes that share domains with GRAPL: view

Function for GRAPL Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GRAPL Gene

Localization for GRAPL Gene

Subcellular locations from

Jensen Localization Image for GRAPL Gene COMPARTMENTS Subcellular localization image for GRAPL gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GRAPL Gene

Pathways & Interactions for GRAPL Gene

genes like me logo Genes that share pathways with GRAPL: view

Pathways by source for GRAPL Gene

2 Reactome pathways for GRAPL Gene

Interacting Proteins for GRAPL Gene

Gene Ontology (GO) - Biological Process for GRAPL Gene


No data available for SIGNOR curated interactions for GRAPL Gene

Drugs & Compounds for GRAPL Gene

No Compound Related Data Available

Transcripts for GRAPL Gene

mRNA/cDNA for GRAPL Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRAPL Gene

GRB2-related adaptor protein-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRAPL Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for GRAPL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRAPL Gene

mRNA expression in normal human tissues for GRAPL Gene

Protein differential expression in normal tissues from HIPED for GRAPL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRAPL Gene

SOURCE GeneReport for Unigene cluster for GRAPL Gene Hs.661470

genes like me logo Genes that share expression patterns with GRAPL: view

Protein tissue co-expression partners for GRAPL Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GRAPL Gene

Orthologs for GRAPL Gene

This gene was present in the common ancestor of animals.

Orthologs for GRAPL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GRAP 36
  • 47 (a)
(Canis familiaris)
Mammalia GRAPL 36
  • 39 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 32 (a)
(Gallus gallus)
Aves GRAP 36
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
(Danio rerio)
Actinopterygii grapa 36
  • 32 (a)
grapb 36
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta drk 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea sem-5 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8309 36
  • 27 (a)
Species with no ortholog for GRAPL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GRAPL Gene

Gene Tree for GRAPL (if available)
Gene Tree for GRAPL (if available)

Paralogs for GRAPL Gene

Paralogs for GRAPL Gene

genes like me logo Genes that share paralogs with GRAPL: view

Variants for GRAPL Gene

Sequence variations from dbSNP and Humsavar for GRAPL Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2019968 -- 19,142,341(-) ctgtt(C/T)cctgt intron-variant
rs2386350 -- 19,149,622(-) CACCA(C/T)GCCCA intron-variant
rs2386353 -- 19,152,816(-) ATGTG(A/C)AACCC intron-variant
rs2386354 -- 19,152,794(-) AAGCA(A/G)TTTTG intron-variant
rs2430876 -- 19,126,835(-) GTCGG(G/T)CGCGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GRAPL Gene

Variant ID Type Subtype PubMed ID
nsv9504 CNV Gain+Loss 18304495
nsv833391 CNV Loss 17160897
esv33572 CNV Gain 17666407
nsv907786 CNV Gain 21882294
nsv428336 CNV Gain+Loss 18775914
dgv933e1 CNV Complex 17122850
dgv3082n71 CNV Loss 21882294
nsv7291 OTHER Inversion 18451855
dgv3083n71 CNV Loss 21882294
dgv3084n71 CNV Gain+Loss 21882294
dgv3085n71 CNV Gain 21882294
nsv907805 CNV Gain+Loss 21882294
dgv3086n71 CNV Gain 21882294
esv25927 CNV Gain+Loss 19812545
dgv3087n71 CNV Gain+Loss 21882294
nsv907825 CNV Loss 21882294
dgv3088n71 CNV Loss 21882294
dgv3089n71 CNV Gain 21882294
nsv2001 CNV Loss 18451855
dgv3090n71 CNV Loss 21882294
dgv3091n71 CNV Gain+Loss 21882294
nsv907835 CNV Gain 21882294
nsv907836 CNV Gain+Loss 21882294
dgv3092n71 CNV Gain+Loss 21882294
dgv3093n71 CNV Gain 21882294
dgv3094n71 CNV Loss 21882294
dgv3095n71 CNV Gain 21882294
dgv3096n71 CNV Gain 21882294
nsv907844 CNV Loss 21882294
dgv3097n71 CNV Gain+Loss 21882294
dgv3098n71 CNV Loss 21882294
dgv3099n71 CNV Gain+Loss 21882294
nsv833393 CNV Gain+Loss 17160897
dgv3100n71 CNV Gain 21882294

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for GRAPL Gene

Disorders for GRAPL Gene

Relevant External Links for GRAPL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GRAPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRAPL Gene

Publications for GRAPL Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 67
  2. Identification of differential protein expression associated with development of unstable human carotid plaques. (PMID: 16507914) Slevin M. … Gaffney J. (Am. J. Pathol. 2006) 23
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for GRAPL Gene

Sources for GRAPL Gene