GRAPL Gene
protein-coding GIFtS: 38
GCID: GC17P019030
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|
GRB2-related adaptor protein-like
| |
Aliases
for GRAPL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| GRB2-Related Adaptor Protein-Like1 2 | | GRB2-Related Adapter Protein LOC4005812 | | GRB2-Related Adapter Protein-Like2 |
Export aliases for GRAPL gene to outside databasesPrevious GC identifer: GC17P018972 |
Summaries
for GRAPL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for GRAPL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for GRAPL
Other transcription factors
Search SABiosciences Chromatin IP Primers for GRAPL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRAPL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p11.2GRAPL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P019030: view genomic region
(about GC identifiers)
Start:
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19,030,782 bp from pter |
End:
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19,062,489 bp from pter |
Size:
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31,708 bases |
Orientation:
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plus strand |
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Proteins
for GRAPL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GRAPL_HUMAN, Q8TC17 (See
protein sequence)Recommended Name: GRB2-related adapter protein-like Size: 118 amino acids; 13442 Da
Secondary accessions: B2RXI8Alternative splicing: 2 isoforms: Q8TC17-1 Q8TC17-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for GRAPL: NX_Q8TC17
GRAPL Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001123250.1
ENSEMBL proteins: ENSP00000437409 ENSP00000466091 ENSP00000465788 ENSP00000459618 ENSP00000464934
Human Recombinant Protein Products for GRAPL:
GRAPL Antibody Products:
Assay Products for GRAPL: |
Protein
Domains /
Families
for GRAPL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GRAPL for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TC17ProtoNet protein and cluster: Q8TC17 UniProtKB/Swiss-Prot: GRAPL_HUMAN, Q8TC17Similarity: Belongs to the GRB2/sem-5/DRK familySimilarity: Contains 1 SH2 domainSimilarity: Contains 1 SH3 domain |
Function
for GRAPL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRAPL
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRAPL
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for GRAPL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRAPL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRAPL |
|
Pathways & Interactions
for GRAPL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GRAPL
|
Drugs & Compounds
for GRAPL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GRAPL
Search CenterWatch for drugs/clinical trials and news about GRAPL
|
Transcripts
for GRAPL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GRAPL gene: NM_001129778.1 Unigene Clusters for GRAPL: GRB2-related adaptor protein-like Hs.661470 [show with all ESTs], Hs.677674 [show with all ESTs]Unigene Representative Sequences: BC060883, BM9252055 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000344415(uc010cqk.1) ENST00000577213 ENST00000437957 ENST00000574324
ENST00000583540
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRAPL
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRAPL
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GRAPL (NM_001129778) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GRAPL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRAPL |
Additional cDNA sequence: BC026233.1 BC157869.1 6 DOTS entries: DT.108652 DT.120923553 DT.100831755 DT.92026222 DT.400143 DT.91821104 3 AceView cDNA sequences: BC026233 BG541579 BX405191
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for GRAPL About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b |
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| SP1: | | | | | | | | | | | |
| SP2: | | | | | - | | | | | |
ECgene alternative splicing isoforms for GRAPL
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Expression
for GRAPL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GRAPL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGGATGACC
About this image
Genevestigator expression for GRAPL
SOURCE GeneReport for Unigene clusters: Hs.661470 Hs.677674
SABiosciences Custom PCR Arrays for GRAPL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GRAPL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat GRAPL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRAPL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRAPL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRAPL |
Orthologs
for GRAPL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for GRAPL gene from 5/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
GRAP6 |
Uncharacterized protein |
38(a) |
1 → many |
14(5184453-5188135) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
36(a) |
1 → many |
GL343618.1(351951-368740) |
zebrafish
(Danio rerio) |
Actinopterygii |
grapb6grapa6 |
GRB2-related adaptor protein a |
31(a)30(a) |
many ↔ manymany ↔ many |
1(7192320-7219398) 3(39625712-39642803) |
fruit fly
(Drosophila melanogaster) |
Insecta |
drk6 |
downstream of receptor kinase |
29(a) |
possible ortholog |
2R(9382727-9390342) |
worm
(Caenorhabditis elegans) |
Secernentea |
sem-56 |
Sex muscle abnormal protein 5 |
25(a) |
possible ortholog |
X(7959779-7961677) |
ENSEMBL Gene Tree for GRAPL (if available)
TreeFam Gene Tree for GRAPL (if available) |
Paralogs
for GRAPL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GRAPL gene
- GRAP2 NCK12 NCK22 GRAP22 GRB22
18/32 SIMAP similar genes for GRAPL using alignment to 5 protein entries: GRAPL_HUMAN (see all proteins)
(see all similar genes):GRAP GRB2 ITSN1 SH3RF3 GRAP2 ARHGEF7
CRK SH3RF1 ITSN2 ABL1 YES1 SH3GL1
BCR/ABL fusion BTK HCK FYN LCK SH3GL2
GRAPL for paralogs About GeneDecksing
|
Genomic Variants
for GRAPL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GRAPL (19030782 - 19062489 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 14 variations for GRAPL
13 CNVs: 77544 30808 4994 4025 72814 35442 72815 35443 7145 88374 72813 77543 32155
1 Inversion: 37187 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GRAPL |
|
Disorders
/ Diseases
for GRAPL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GRAPL for disorders About GeneDecksing
1  disease for GRAPL: About MalaCardsneuronitis
Export disorders for GRAPL gene to outside databases
|
Publications
for GRAPL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GRAPL gene integrated from 9 sources:
(articles sorted by number of sources associating them with GRAPL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Identification of differential protein expression associated with development of unstable human carotid plaques. (PubMed id 16507914)9 Slevin M....Gaffney J. (2006)
|
External Searches for GRAPL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GRAPL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GRAPL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GRAPL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GRAPL | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GRAPL gene:
Search GeneIP for patents involving GRAPL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GRAPL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | Browse OriGene 29mer shRNA kits in GFP-retroviral vector | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GRAPL | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRAPL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRAPL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | | Search Tocris compounds for GRAPL |
| |  |  |  |  | | | | |
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 |
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 | | | GRAPL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRAPL |
|  |  |  |  | | | | Search ThermoFisher Antibodies for GRAPL |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRAPL |
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