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Aliases for GRAPL Gene

Aliases for GRAPL Gene

  • GRB2 Related Adaptor Protein Like 2 3 5

External Ids for GRAPL Gene

Previous GeneCards Identifiers for GRAPL Gene

  • GC17P018972
  • GC17P019030

Summaries for GRAPL Gene

GeneCards Summary for GRAPL Gene

GRAPL (GRB2 Related Adaptor Protein Like) is a Protein Coding gene. Among its related pathways are RET signaling and Signaling by GPCR. An important paralog of this gene is GRAP.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRAPL Gene

Genomics for GRAPL Gene

Regulatory Elements for GRAPL Gene

Enhancers for GRAPL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G019502 0.8 FANTOM5 ENCODE 4.4 +375.1 375069 1.0 BCOR ZMYM3 KDM1A GRAPL GC17P019639 RPL17P43
GH17G019126 0.5 dbSUPER 0.7 +1.0 1047 3.9 CTCF ZNF654 PKNOX1 DPF2 GRAPL ENSG00000262319
GH17G019125 0.5 Ensembl dbSUPER 0.7 -1.8 -1769 0.2 GRAPL ENSG00000262202 SNORD3D GC17M019113
GH17G019131 0.5 Ensembl dbSUPER 0.7 +3.9 3889 0.5 GRAPL ENSG00000262319
GH17G019118 0.8 dbSUPER 0.4 -8.0 -8021 2.0 BCOR PTBP1 ATF1 ZMYM3 ZIC2 GATA3 POLR2A ADNP KLF8 ZNF263 ENSG00000262202 GRAPL SNORD3D GC17M019113
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GRAPL on UCSC Golden Path with GeneCards custom track

Promoters for GRAPL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000092173 431 601

Genomic Location for GRAPL Gene

19,127,469 bp from pter
19,159,176 bp from pter
31,708 bases
Plus strand

Genomic View for GRAPL Gene

Genes around GRAPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRAPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRAPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRAPL Gene

Proteins for GRAPL Gene

  • Protein details for GRAPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GRB2-related adapter protein-like
    Protein Accession:
    Secondary Accessions:
    • B2RXI8

    Protein attributes for GRAPL Gene

    118 amino acids
    Molecular mass:
    13442 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GRAPL Gene


neXtProt entry for GRAPL Gene

Post-translational modifications for GRAPL Gene

No Post-translational modifications

No data available for DME Specific Peptides for GRAPL Gene

Domains & Families for GRAPL Gene

Gene Families for GRAPL Gene

Protein Domains for GRAPL Gene


Suggested Antigen Peptide Sequences for GRAPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GRB2/sem-5/DRK family.
  • Belongs to the GRB2/sem-5/DRK family.
genes like me logo Genes that share domains with GRAPL: view

Function for GRAPL Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GRAPL Gene

Localization for GRAPL Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRAPL gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GRAPL Gene

Pathways & Interactions for GRAPL Gene

SuperPathways for GRAPL Gene

SuperPathway Contained pathways
1 Signaling by GPCR
2 RET signaling
genes like me logo Genes that share pathways with GRAPL: view

Pathways by source for GRAPL Gene

2 Reactome pathways for GRAPL Gene

Gene Ontology (GO) - Biological Process for GRAPL Gene


No data available for SIGNOR curated interactions for GRAPL Gene

Drugs & Compounds for GRAPL Gene

No Compound Related Data Available

Transcripts for GRAPL Gene

mRNA/cDNA for GRAPL Gene

(5) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRAPL Gene

GRB2-related adaptor protein-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRAPL Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for GRAPL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRAPL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRAPL Gene

Protein differential expression in normal tissues from HIPED for GRAPL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRAPL Gene

Protein tissue co-expression partners for GRAPL Gene

NURSA nuclear receptor signaling pathways regulating expression of GRAPL Gene:


SOURCE GeneReport for Unigene cluster for GRAPL Gene:

genes like me logo Genes that share expression patterns with GRAPL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRAPL Gene

Orthologs for GRAPL Gene

This gene was present in the common ancestor of animals.

Orthologs for GRAPL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GRAP 35
  • 47 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 45 (a)
(Canis familiaris)
Mammalia GRAPL 35
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 32 (a)
(Gallus gallus)
Aves GRAP 35
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 38 (a)
(Danio rerio)
Actinopterygii grapb 35
  • 33 (a)
grapa 35
  • 32 (a)
fruit fly
(Drosophila melanogaster)
Insecta drk 35
  • 31 (a)
(Caenorhabditis elegans)
Secernentea sem-5 35
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8309 35
  • 27 (a)
Species where no ortholog for GRAPL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GRAPL Gene

Gene Tree for GRAPL (if available)
Gene Tree for GRAPL (if available)

Paralogs for GRAPL Gene

Paralogs for GRAPL Gene

genes like me logo Genes that share paralogs with GRAPL: view

Variants for GRAPL Gene

Sequence variations from dbSNP and Humsavar for GRAPL Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1002170357 -- 19,151,667(+) TACGC(C/T)TCCCA intron-variant, downstream-variant-500B
rs1003178451 -- 19,142,185(+) CAGGG(G/T)TCTCT intron-variant
rs1003289547 -- 19,144,023(+) ACCAG(C/T)GTCCT intron-variant
rs1003969866 -- 19,147,468(+) CAGGC(C/T)AGGAC intron-variant, utr-variant-3-prime
rs1004086008 -- 19,149,160(+) CCGTC(C/T)CTACT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GRAPL Gene

Variant ID Type Subtype PubMed ID
dgv1705e59 CNV duplication 20981092
dgv1706e59 CNV duplication 20981092
dgv3116n100 CNV gain 25217958
dgv5492n54 CNV loss 21841781
dgv5493n54 CNV loss 21841781
dgv5494n54 CNV loss 21841781
dgv5495n54 CNV loss 21841781
dgv5496n54 CNV loss 21841781
dgv895e212 CNV loss 25503493
esv25927 CNV gain+loss 19812545
esv2758678 CNV gain+loss 17122850
esv2763157 CNV loss 21179565
esv3330222 CNV duplication 20981092
esv3352703 CNV duplication 20981092
esv3352743 CNV duplication 20981092
esv33572 CNV gain 17666407
esv3367269 CNV duplication 20981092
esv3375507 CNV duplication 20981092
esv3385860 CNV duplication 20981092
esv3892975 CNV loss 25118596
esv3892976 CNV loss 25118596
esv3892977 CNV loss 25118596
esv3892978 CNV loss 25118596
esv3892979 CNV loss 25118596
nsv1061317 CNV gain 25217958
nsv2001 CNV deletion 18451855
nsv428336 CNV gain+loss 18775914
nsv574555 CNV loss 21841781
nsv574569 CNV loss 21841781
nsv7291 OTHER inversion 18451855
nsv833391 CNV loss 17160897
nsv833393 CNV gain+loss 17160897
nsv9504 CNV gain+loss 18304495
nsv953843 CNV deletion 24416366
nsv960073 CNV duplication 23825009
nsv960434 CNV duplication 23825009
nsv960435 CNV duplication 23825009
nsv978386 CNV duplication 23825009
nsv978479 CNV duplication 23825009

Relevant External Links for GRAPL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GRAPL Gene

Disorders for GRAPL Gene

Relevant External Links for GRAPL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GRAPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRAPL Gene

Publications for GRAPL Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  2. Identification of differential protein expression associated with development of unstable human carotid plaques. (PMID: 16507914) Slevin M. … Gaffney J. (Am. J. Pathol. 2006) 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for GRAPL Gene

Sources for GRAPL Gene

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