Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GRAP2 Gene

protein-coding   GIFtS: 65
GCID: GC22P040297

GRB2-Related Adaptor Protein 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
GRB2-Related Adaptor Protein 21 2     GRPL2
GRID2 3 5     GrbX2
Adapter Protein GRID2 3     Grf402
Grf40 Adapter Protein2 3     Mona2
Growth Factor Receptor-Binding Protein2 3     GRB2-Related Adapter Protein 22
Hematopoietic Cell-Associated Adapter Protein GrpL2 3     GRB2-Related Protein With Insert Domain2
GADS2 3     grf-402
GRB2L2 3     Growth Factor Receptor-Bound Protein 2-Related Adaptor Protein 22
GRBLG2 3     Hematopoietic Cell-Associated Adaptor Protein GRPL2
P382 3     SH3-SH2-SH3 Adaptor Molecule2
GRB-2-Like Protein2 3     GRBX3
SH3-SH2-SH3 Adapter Mona2 3     Grf-403
GRAP-22     Protein GADS3

External Ids:    HGNC: 45631   Entrez Gene: 94022   Ensembl: ENSG000001003517   OMIM: 6045185   UniProtKB: O757913   

Export aliases for GRAP2 gene to outside databases

Previous GC identifers: GC22P036911 GC22P038540 GC22P038621 GC22P023272


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GRAP2 Gene:
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in
leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor
protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other
proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its
SH3 domains. Transcript variants utilizing alternative polyA sites exist. (provided by RefSeq, Jul 2008)

GeneCards Summary for GRAP2 Gene: 
GRAP2 (GRB2-related adaptor protein 2) is a protein-coding gene. Diseases associated with GRAP2 include potter's syndrome, and retinal telangiectasia, and among its related super-pathways are Costimulation by the CD28 family and T cell receptor signaling pathway. GO annotations related to this gene include SH3/SH2 adaptor activity and protein binding. An important paralog of this gene is GRAP.

UniProtKB/Swiss-Prot: GRAP2_HUMAN, O75791
Function: Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc

Gene Wiki entry for GRAP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GRAP2 gene promoter:
         TBP   AML1a   Brachyury   CUTL1   STAT5A   IRF-2   SRY   NF-AT4   NF-AT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRAP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for GRAP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.2

GRAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRAP2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P040297:  view genomic region     (about GC identifiers)

Start:
40,297,086 bp from pter      End:
40,369,725 bp from pter
Size:
72,640 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GRAP2_HUMAN, O75791 (See protein sequence)
Recommended Name: GRB2-related adapter protein 2  
Size: 330 amino acids; 37909 Da
Subunit: Interacts with phosphorylated LIME1 upon TCR activation (By similarity). Interacts with phosphorylated
LAT and LAX1 upon TCR activation. Interacts with SHB. Interacts with PTPN23
Subcellular location: Nucleus. Cytoplasm. Endosome
Secondary accessions: O43726 Q9NRB7

Explore the universe of human proteins at neXtProt for GRAP2: NX_O75791

Explore proteomics data for GRAP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75791

  • GRAP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GRAP2 Protein Expression
    REFSEQ proteins: NP_004801.1  
    ENSEMBL proteins: 
     ENSP00000339186   ENSP00000396355   ENSP00000385607   ENSP00000444734   ENSP00000446350  
     ENSP00000382040   ENSP00000442195  
    Reactome Protein details: O75791
    Human Recombinant Protein Products for GRAP2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for GRAP2
    OriGene Protein Over-expression Lysate for GRAP2
    OriGene MassSpec for GRAP2 
    OriGene Custom Protein Services for GRAP2
    GenScript Custom Purified and Recombinant Proteins Services for GRAP2
    Novus Biologicals GRAP2 Proteins
    Novus Biologicals GRAP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for GRAP2
    Cloud-Clone Corp. Proteins for GRAP2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005768endosome IDA--
    GO:0005829cytosol TAS--

    GRAP2 for ontologies           About GeneDecksing



    GRAP2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of GRAP2
    R&D Systems Antibodies for GRAP2
    OriGene Antibodies for GRAP2
    OriGene Custom Antibody Services for GRAP2
    GenScript Custom Superior Antibodies Services for GRAP2
    Novus Biologicals GRAP2 Antibodies
    Abcam antibodies for GRAP2
    Cloud-Clone Corp. Antibodies for GRAP2 
    ThermoFisher Antibodies for GRAP2
    LSBio Antibodies in human, mouse, rat for GRAP2 

    Assay Products for GRAP2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GRAP2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GRAP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GRAP2 
    Cloud-Clone Corp. CLIAs for GRAP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SH2D: SH2 domain containing

    2 InterPro protein domains:
     IPR001452 SH3_domain
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry O75791

    ProtoNet protein and cluster: O75791

    2 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature


    UniProtKB/Swiss-Prot: GRAP2_HUMAN, O75791
    Similarity: Belongs to the GRB2/sem-5/DRK family
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 2 SH3 domains


    GRAP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRAP2_HUMAN, O75791
    Function: Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc

         Genatlas biochemistry entry for GRAP2:
    Grb2-related adaptor protein 2,expressed in thymus and spleen interacting with cKIT,EPOR,coupling tyrosine kinase
    to the RAS pathway

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity TAS9878555
    GO:0005515protein binding IPI12359715
         
    GRAP2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for GRAP2:
     Increased S DNA content  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Grap2):
     cellular  hematopoietic system  immune system 

    GRAP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GRAP2: Grap2tm1Amch Grap2tm1Eac

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GRAP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GRAP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRAP2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GRAP2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GRAP2
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate GRAP2:
    hsa-miR-4286 hsa-miR-502-5p hsa-miR-192*
    SwitchGear 3'UTR luciferase reporter plasmidGRAP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GRAP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRAP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GRAP2
    Sirion Biotech Customized adenovirus for overexpression of GRAP2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GRAP2 (see all 7)
    OriGene ORF clones in mouse, rat for GRAP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GRAP2 (NM_004810)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRAP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRAP2
    Sirion Biotech Customized lentivirus for stable overexpression of GRAP2 
                         Customized lentivirus expression plasmids for stable overexpression of GRAP2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GRAP2
    Search LifeMap BioReagents cell lines for GRAP2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRAP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GRAP2 About   (see all 19)                                                                                              See pathways by source

    SuperPathContained pathways About
    1CD28 co-stimulation
    CD28 co-stimulation0.66
    CTLA4 Signaling0.31
    Costimulation by the CD28 family0.41
    2B cell receptor signaling pathway
    T cell receptor signaling pathway0.38
    TCR Signaling Pathway0.35
    3Immune System
    Immune System0.56
    Innate Immune System0.50
    Adaptive Immune System0.56
    4PKC-Theta Pathway
    TCR Signaling0.68
    ITK and TCR Signaling0.54
    PKC-Theta Pathway0.68
    5Signaling by FGFR
    DAP12 signaling0.91
    DAP12 interactions0.91

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for GRAP2
        Immune response CD28 signaling

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GRAP2 (see all 9)
        ICos-ICosL Pathway in T-Helper Cell
    Rap1 Pathway
    CD28 Signaling in T-Helper Cell
    CTLA4 Signaling
    ITK and TCR Signaling

    1 GeneGo (Thomson Reuters) Pathway for GRAP2
        Immune response CD28 signaling

    5 BioSystems Pathways for GRAP2
        TCR Signaling Pathway
    TCR signaling in naive CD4+ T cells
    TCR signaling in naive CD8+ T cells
    JNK signaling in the CD4+ TCR pathway
    Signaling events mediated by Stem cell factor receptor (c-Kit)

    5/14        Reactome Pathways for GRAP2 (see all 14)
        FCERI mediated MAPK activation
    Costimulation by the CD28 family
    Adaptive Immune System
    DAP12 interactions
    DAP12 signaling


    1         Kegg Pathway  (Kegg details for GRAP2):
        T cell receptor signaling pathway


    GRAP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/88 Interacting proteins for GRAP2 (O757911, 2, 3 ENSP000003391864) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LCP2Q130942, 3, ENSP000000467944MINT-4302429 MINT-7306546 MINT-4302374 MINT-4302356 MINT-4302410 MINT-4302332 MINT-7041321 MINT-4302284 MINT-4302391 I2D: score=10 STRING: ENSP00000046794
    ERBB2P046262, 3, ENSP000002695714MINT-74540 I2D: score=2 STRING: ENSP00000269571
    ASAP1Q9ULH12, 3, ENSP000003502974MINT-7145768 I2D: score=1 STRING: ENSP00000350297
    PTPN23Q9H3S71, 2, 3, ENSP000002655624EBI-740418,EBI-724478 MINT-7220138 MINT-7220391 MINT-7220432 I2D: score=1 STRING: ENSP00000265562
    CD28P107472, 3, ENSP000003248904MINT-8036810 MINT-8036795 I2D: score=4 STRING: ENSP00000324890
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007265Ras protein signal transduction TAS9878555
    GO:0007267cell-cell signaling TAS9878555
    GO:0031295T cell costimulation TAS--
    GO:0038095Fc-epsilon receptor signaling pathway TAS--
    GO:0045087innate immune response TAS--

    GRAP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GRAP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GRAP2

    4 Novoseek inferred chemical compound relationships for GRAP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 61 23 15029250 (2), 12186560 (2), 16493040 (2), 15735648 (2) (see all 13)
    phosphotyrosine 52.3 1 12356870 (1)
    lipid 0 1 12356870 (1)
    calcium 0 1 12356870 (1)

    Search CenterWatch for drugs/clinical trials and news about GRAP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GRAP2 gene: 
    NM_004810.2  

    Unigene Cluster for GRAP2:

    GRB2-related adaptor protein 2
    Hs.517499  [show with all ESTs]
    Unigene Representative Sequence: BC026002
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344138(uc003ayh.2 uc011aom.2 uc011aon.2 uc003ayj.2)
    ENST00000420971 ENST00000478445 ENST00000461082 ENST00000407075 ENST00000481263
    ENST00000460449 ENST00000540310 ENST00000543252 ENST00000399090 ENST00000544756(uc010gya.2 uc011aoo.2 uc011aop.2 uc011aoq.2)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GRAP2
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate GRAP2:
    hsa-miR-4286 hsa-miR-502-5p hsa-miR-192*
    SwitchGear 3'UTR luciferase reporter plasmidGRAP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GRAP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRAP2
    Clone
    Products:
         
    OriGene clones in human, mouse for GRAP2 (see all 7)
    OriGene ORF clones in mouse, rat for GRAP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GRAP2 (NM_004810)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRAP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRAP2
    Sirion Biotech Customized lentivirus for stable overexpression of GRAP2 
                         Customized lentivirus expression plasmids for stable overexpression of GRAP2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GRAP2
    OriGene qSTAR qPCR primer pairs in human, mouse for GRAP2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GRAP2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRAP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRAP2

    Additional mRNA sequence: 

    AF042380.1 AF090456.1 AF102694.1 AF121002.1 AF129476.1 AF236119.1 AF236120.1 AJ011736.1 
    AK303280.1 AK303332.1 AK303470.1 AK303512.1 AK303657.1 AK312830.1 AY069959.1 BC025692.1 
    BC026002.1 CR456498.1 CR536524.1 CR541849.1 Y18051.1 

    8 DOTS entries:

    DT.433702  DT.95171199  DT.120671271  DT.407834  DT.87015062  DT.100670611  DT.120671280  DT.97777471 

    24/75 AceView cDNA sequences (see all 75):

    AA669142 CR604186 H55177 AI248165 AF042380 CR536524 AF236120 CR598431 
    AF090456 N57907 CR607150 BC025692 CR456498 NM_004810 AW188251 BI518664 
    R02185 BX371694 BE646273 AF121002 AJ011736 BI772011 BX387888 AF236119 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for GRAP2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5
    SP1:                                                
    SP2:              -                                 


    ECgene alternative splicing isoforms for GRAP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GRAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTATATATA
    GRAP2 Expression
    About this image


    See GRAP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GRAP2

    SOURCE GeneReport for Unigene cluster: Hs.517499
        SABiosciences Custom PCR Arrays for GRAP2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GRAP2
    OriGene qSTAR qPCR primer pairs in human, mouse for GRAP2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GRAP2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRAP2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRAP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRAP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GRAP2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grap21 , 5 GRB2-related adaptor protein 21, 5 84.16(n)1
    88.2(a)1
      15 (37.88 cM)5
    174441  NM_010815.21  NP_034945.11 
     806234835 
    chicken
    (Gallus gallus)
    Aves GRAP21 GRB2-related adaptor protein 2 69.17(n)
    68.26(a)
      770756  XM_001234081.2  XP_001234082.2 
    lizard
    (Anolis carolinensis)
    Reptilia GRAP26
    GRB2-related adaptor protein 2
    60(a)
    1 ↔ 1
    5(25471269-25539376)
    zebrafish
    (Danio rerio)
    Actinopterygii BC058307.12   -- 82.54(n)   393651  BC058307.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nck-16
    Protein NCK-1, isoform a
    13(a)
    possible ortholog
    X(4148649-4153443)


    ENSEMBL Gene Tree for GRAP2 (if available)
    TreeFam Gene Tree for GRAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GRAP2 gene
    GRAP2  GRAPL2  NCK12  NCK22  GRB22  
    18/38 SIMAP similar genes for GRAP2 using alignment to 8 protein entries:     GRAP2_HUMAN (see all proteins) (see all similar genes):
    ITSN2    ITSN1    GRAP    PSTPIP1    GRAPL    AHI1
    EPS8    VAV1    HCK    KIAA0142    PPP1R13B    SH3D19
    ARHGEF7    SH3GL2    BLK    CRK    SH3GL1    ABL1

    GRAP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1271 SNPs in GRAP2 are shown (see all 1271)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs675645651,2
    C--24234922(+) CACAG-/ACACA 
     CACACAC
    ACACA
    1 -- int10--------
    rs1912786441,2
    --40295167(+) TCAATC/TAGTAC 1 -- us2k10--------
    rs1157324561,2
    F--40295246(+) GGATTA/GTATTC 1 -- us2k11Minor allele frequency- G:0.05WA 118
    rs60017031,2
    C,H--40295286(+) AATTAG/ACTTCC 1 -- us2k15Minor allele frequency- A:0.00NS EA NA 422
    rs1837938731,2
    --40295370(+) CTCCCC/TAACCA 1 -- us2k10--------
    rs738856081,2
    C,F--40295452(+) GCCAGA/CGGATT 1 -- us2k12Minor allele frequency- C:0.07WA 120
    rs354579551,2
    C--40295575(+) CAAGA-/TGTTGTTA 1 -- us2k10--------
    rs1379581,2
    C--40295576(+) ATGTT-/GTTATTTT 1 -- us2k10--------
    rs2004514061,2
    C--40295579(+) ATGTTA/GTTATT 1 -- us2k10--------
    rs1893170951,2
    --40295642(+) ACCAGA/GATTTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GRAP2 (40297086 - 40369725 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GRAP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv510808CNV Loss20534489
    nsv834201CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GRAP2
    DNA2.0 Custom Variant and Variant Library Synthesis for GRAP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604518    OMIM disorders: --

    13 diseases for GRAP2:    About MalaCards
    potter's syndrome    retinal telangiectasia    silver-russell syndrome    fanconi's anemia
    anemia    hepatitis c    hepatitis    hepatitis b
    thyroiditis    hepatocellular carcinoma    pancreatitis    retinitis
    leukemia

    2 diseases from the University of Copenhagen DISEASES database for GRAP2:
    Potter's syndrome     Silver-Russell syndrome

    GRAP2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for GRAP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 0 2 9831174 (1)
    tumors 0 4 19027225 (1), 9831174 (1)

    Genetic Association Database (GAD): GRAP2
    Human Genome Epidemiology (HuGE) Navigator: GRAP2 (4 documents)

    Export disorders for GRAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GRAP2 gene, integrated from 9 sources (see all 88):
    (articles sorted by number of sources associating them with GRAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of human grap-2, a novel leukocyte- specific SH2- and SH3-containing adaptor-like protein that binds to gab-1. (PubMed id 9878555)1, 2, 3, 9 Qiu M....Liu M. (1998)
    2. Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT. (PubMed id 10224278)1, 2, 3 Asada H.... Sugamura K. (1999)
    3. Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. (PubMed id 10811803)1, 2, 9 Zhang W.... Samelson L.E. (2000)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Histidine domain-protein tyrosine phosphatase interac ts with Grb2 and GrpL. (PubMed id 21179510)1, 2 Tanase C.A. (2010)
    6. Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients . (PubMed id 19817957)1, 4 Segat L....Crovella S. (2009)
    7. Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)1, 4 Saito T....Kawata S. (2004)
    8. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    9. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9402 HGNC: 4563 AceView: GRAP2 Ensembl:ENSG00000100351 euGenes: HUgn9402
    ECgene: GRAP2 Kegg: 9402 H-InvDB: GRAP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GRAP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GRAP2 gene:
    Search GeneIP for patents involving GRAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of GRAP2
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for GRAP2 (GRAP2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GRAP2   OriGene RNAi products in human, mouse, rat for GRAP2  
     OriGene qPCR primer pairs and template standards for GRAP2   OriGene Protein Over-expression Lysate for GRAP2  
     OriGene MassSpec something-or-other for GRAP2   OriGene clones in human, mouse for GRAP2  
     OriGene qSTAR qPCR primer pairs in human, mouse for GRAP2   OriGene Purified Protein for GRAP2  
     OriGene ORF clones in mouse, rat for GRAP2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GRAP2   OriGene Custom Protein Services for GRAP2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GRAP2
     QIAGEN SeqTarget long-range PCR primers for resequencing GRAP2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRAP2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRAP2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRAP2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRAP2
     GenScript Custom Purified and Recombinant Proteins Services for GRAP2 GenScript cDNA clones with any tag delivered in your preferred vector for GRAP2
     GenScript Custom Assay Services for GRAP2 GenScript Custom Superior Antibodies Services for GRAP2
     GenScript Custom overexpressing Cell Line Services for GRAP2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in GRAP2 promoter
     Search Chromatin IP Primers for GRAP2
     RT2 qPCR Primer Assay in human, mouse, rat GRAP2
     GNC Network for GRAP2
     SABiosciences PCR Arrays including human, mouse, rat GRAP2
     Search Tocris compounds for GRAP2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GRAP2 antibodies
     GRAP2 proteins
     GRAP2 lysates
     Antibodies for GRAP2
     See all of Abcam's Antibodies, Kits and Proteins for GRAP2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for GRAP2




     Proteins for GRAP2
     Antibodies for GRAP2
     ELISAs for GRAP2
     CLIAs for GRAP2
     Search LifeMap BioReagents cell lines for GRAP2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRAP2
     SwitchGear 3'UTR luciferase reporter plasmids for GRAP2
     SwitchGear Promoter luciferase reporter plasmids for GRAP2
     ThermoFisher Antibodies for GRAP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRAP2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GRAP2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GRAP2
    Customized:
     lentivirus for stable overexpression of GRAP2
     lentivirus expression plasmids for stable overexpression of GRAP2
     adenovirus for overexpression of GRAP2
     LSBio Antibodies in human, mouse, rat for GRAP2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GRAP2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4