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Aliases for GRAP2 Gene

Aliases for GRAP2 Gene

  • GRB2-Related Adaptor Protein 2 2 3
  • GRID 3 4 6
  • Hematopoietic Cell-Associated Adapter Protein GrpL 3 4
  • Growth Factor Receptor-Binding Protein 3 4
  • SH3-SH2-SH3 Adapter Mona 3 4
  • Grf40 Adapter Protein 3 4
  • Adapter Protein GRID 3 4
  • GRB-2-Like Protein 3 4
  • Grf-40 3 4
  • GRB2L 3 4
  • GRBLG 3 4
  • GrbX 3 4
  • GADS 3 4
  • P38 3 4
  • Growth Factor Receptor-Bound Protein 2-Related Adaptor Protein 2 3
  • Hematopoietic Cell-Associated Adaptor Protein GRPL 3
  • GRB2-Related Protein With Insert Domain 3
  • GRB2-Related Adapter Protein 2 3
  • SH3-SH2-SH3 Adaptor Molecule 3
  • Protein GADS 4
  • GRAP-2 3
  • Grf40 3
  • GRPL 3
  • Mona 3

External Ids for GRAP2 Gene

Summaries for GRAP2 Gene

Entrez Gene Summary for GRAP2 Gene

  • This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

GeneCards Summary for GRAP2 Gene

GRAP2 (GRB2-Related Adaptor Protein 2) is a Protein Coding gene. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is GRAPL.

UniProtKB/Swiss-Prot for GRAP2 Gene

  • Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc

Gene Wiki entry for GRAP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRAP2 Gene

Genomics for GRAP2 Gene

Genomic Location for GRAP2 Gene

Start:
39,901,082 bp from pter
End:
39,973,721 bp from pter
Size:
72,640 bases
Orientation:
Plus strand

Genomic View for GRAP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRAP2 Gene

Regulatory Elements for GRAP2 Gene

Proteins for GRAP2 Gene

  • Protein details for GRAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75791-GRAP2_HUMAN
    Recommended name:
    GRB2-related adapter protein 2
    Protein Accession:
    O75791
    Secondary Accessions:
    • B7Z8I3
    • O43726
    • Q9NRB7

    Protein attributes for GRAP2 Gene

    Size:
    330 amino acids
    Molecular mass:
    37909 Da
    Quaternary structure:
    • Interacts with phosphorylated LIME1 upon TCR activation (By similarity). Interacts with phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB. Interacts with PTPN23.

    Alternative splice isoforms for GRAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRAP2 Gene

Proteomics data for GRAP2 Gene at MOPED

Post-translational modifications for GRAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys141

Other Protein References for GRAP2 Gene

No data available for DME Specific Peptides for GRAP2 Gene

Domains for GRAP2 Gene

Gene Families for GRAP2 Gene

HGNC:
  • SH2D :SH2 domain containing

Protein Domains for GRAP2 Gene

UniProtKB/Swiss-Prot:

GRAP2_HUMAN
Domain:
  • Contains 1 SH2 domain.:
    • O75791
  • Contains 2 SH3 domains.:
    • O75791
Family:
  • Belongs to the GRB2/sem-5/DRK family.:
    • O75791
genes like me logo Genes that share domains with GRAP2: view

Function for GRAP2 Gene

Molecular function for GRAP2 Gene

GENATLAS Biochemistry: Grb2-related adaptor protein 2,expressed in thymus and spleen interacting with cKIT,EPOR,coupling tyrosine kinase to the RAS pathway
UniProtKB/Swiss-Prot Function: Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc

Gene Ontology (GO) - Molecular Function for GRAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 9878555
GO:0005515 protein binding IPI 12359715
genes like me logo Genes that share ontologies with GRAP2: view

Phenotypes for GRAP2 Gene

genes like me logo Genes that share phenotypes with GRAP2: view

Animal Models for GRAP2 Gene

MGI Knock Outs for GRAP2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GRAP2 Gene

Localization for GRAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRAP2 Gene

Nucleus. Cytoplasm. Endosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRAP2 Gene COMPARTMENTS Subcellular localization image for GRAP2 gene
Compartment Confidence
endosome 5
nucleus 5
cytosol 4
cytoskeleton 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GRAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21179510
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005768 endosome IDA 21179510
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with GRAP2: view

Pathways for GRAP2 Gene

genes like me logo Genes that share pathways with GRAP2: view

Gene Ontology (GO) - Biological Process for GRAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007265 Ras protein signal transduction TAS 9878555
GO:0007267 cell-cell signaling TAS 9878555
GO:0009967 positive regulation of signal transduction TAS 9878555
GO:0031295 T cell costimulation TAS --
GO:0038095 Fc-epsilon receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with GRAP2: view

Compounds for GRAP2 Gene

(4) Novoseek inferred chemical compound relationships for GRAP2 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 61 19
phosphotyrosine 52.3 1
lipid 0 1
calcium 0 1
genes like me logo Genes that share compounds with GRAP2: view

Transcripts for GRAP2 Gene

Unigene Clusters for GRAP2 Gene

GRB2-related adaptor protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRAP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1:
SP2: -

Relevant External Links for GRAP2 Gene

GeneLoc Exon Structure for
GRAP2
ECgene alternative splicing isoforms for
GRAP2

Expression for GRAP2 Gene

mRNA expression in normal human tissues for GRAP2 Gene

mRNA differential expression in normal tissues according to GTEx for GRAP2 Gene

This gene is overexpressed in Whole Blood (20.5) and Spleen (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GRAP2 Gene

SOURCE GeneReport for Unigene cluster for GRAP2 Gene Hs.517499

genes like me logo Genes that share expressions with GRAP2: view

Orthologs for GRAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRAP2 36
  • 99.39 (n)
  • 99.7 (a)
GRAP2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GRAP2 36
  • 86.81 (n)
  • 88.29 (a)
GRAP2 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRAP2 36
  • 90.05 (n)
  • 93.97 (a)
GRAP2 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grap2 36
  • 83.02 (n)
  • 86.02 (a)
Grap2 16
Grap2 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRAP2 37
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRAP2 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grap2 36
  • 83.28 (n)
  • 85.14 (a)
chicken
(Gallus gallus)
Aves GRAP2 36
  • 68.82 (n)
  • 67.35 (a)
GRAP2 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRAP2 37
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grap2 36
  • 55.52 (n)
  • 50.5 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 36
grap2a 37
  • 52 (a)
OneToMany
grap2b 36
  • 60.59 (n)
  • 54.24 (a)
grap2b 37
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta drk 37
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sem-5 37
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8309 37
  • 44 (a)
OneToMany
Species with no ortholog for GRAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRAP2 Gene

ENSEMBL:
Gene Tree for GRAP2 (if available)
TreeFam:
Gene Tree for GRAP2 (if available)

Paralogs for GRAP2 Gene

Paralogs for GRAP2 Gene

genes like me logo Genes that share paralogs with GRAP2: view

Variants for GRAP2 Gene

Sequence variations from dbSNP and Humsavar for GRAP2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs12759 - 39,971,046(+) TGGGC(C/T)TCTTC reference, missense
rs80400 -- 39,955,454(+) CCTTC(C/T)CACCA intron-variant
rs80403 -- 39,918,048(+) GATTT(A/T)TCCTT intron-variant
rs107140 -- 39,938,923(+) CGGAC(A/G)AGCTG intron-variant
rs137958 -- 39,899,572(+) ATGTT(-/GTT)ATTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GRAP2 Gene

Variant ID Type Subtype PubMed ID
nsv510808 CNV Loss 20534489
nsv834201 CNV Gain 17160897

Relevant External Links for GRAP2 Gene

HapMap Linkage Disequilibrium report
GRAP2

Disorders for GRAP2 Gene

(2) University of Copenhagen DISEASES for GRAP2 Gene

(2) Novoseek inferred disease relationships for GRAP2 Gene

Disease -log(P) Hits PubMed IDs
necrosis 0 1
tumors 0 2

Relevant External Links for GRAP2

Genetic Association Database (GAD)
GRAP2
Human Genome Epidemiology (HuGE) Navigator
GRAP2
genes like me logo Genes that share disorders with GRAP2: view

No data available for UniProtKB/Swiss-Prot for GRAP2 Gene

Publications for GRAP2 Gene

  1. Molecular cloning and expression of human grap-2, a novel leukocyte- specific SH2- and SH3-containing adaptor-like protein that binds to gab-1. (PMID: 9878555) Qiu M. … Liu M. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23
  2. Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling. (PMID: 10811803) Zhang W. … Samelson L.E. (J. Biol. Chem. 2000) 3 4 23
  3. Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT. (PMID: 10224278) Asada H. … Sugamura K. (J. Exp. Med. 1999) 2 3 4
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  5. Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. (PMID: 12522270) Salomon A.R. … Peters E.C. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4

Products for GRAP2 Gene

Sources for GRAP2 Gene

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