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Aliases for GRAP2 Gene

Aliases for GRAP2 Gene

  • GRB2-Related Adaptor Protein 2 2 3 5
  • Hematopoietic Cell-Associated Adapter Protein GrpL 3 4
  • Growth Factor Receptor-Binding Protein 3 4
  • SH3-SH2-SH3 Adapter Mona 3 4
  • Grf40 Adapter Protein 3 4
  • Adapter Protein GRID 3 4
  • GRB-2-Like Protein 3 4
  • Grf-40 3 4
  • GRB2L 3 4
  • GRBLG 3 4
  • GrbX 3 4
  • GADS 3 4
  • GRID 3 4
  • P38 3 4
  • Growth Factor Receptor-Bound Protein 2-Related Adaptor Protein 2 3
  • Hematopoietic Cell-Associated Adaptor Protein GRPL 3
  • GRB2-Related Protein With Insert Domain 3
  • GRB2-Related Adapter Protein 2 3
  • SH3-SH2-SH3 Adaptor Molecule 3
  • Protein GADS 4
  • GRAP-2 3
  • Grf40 3
  • GRPL 3
  • Mona 3

External Ids for GRAP2 Gene

Previous GeneCards Identifiers for GRAP2 Gene

  • GC22P036911
  • GC22P038540
  • GC22P038621
  • GC22P040297
  • GC22P023272

Summaries for GRAP2 Gene

Entrez Gene Summary for GRAP2 Gene

  • This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

GeneCards Summary for GRAP2 Gene

GRAP2 (GRB2-Related Adaptor Protein 2) is a Protein Coding gene. Among its related pathways are RET signaling and Immune System. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is GRB2.

UniProtKB/Swiss-Prot for GRAP2 Gene

  • Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.

Gene Wiki entry for GRAP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRAP2 Gene

Genomics for GRAP2 Gene

Regulatory Elements for GRAP2 Gene

Enhancers for GRAP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F039946 1.7 FANTOM5 Ensembl ENCODE 13.2 +56.1 56071 7.8 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000225528 GRAP2 ENTHD1 FAM83F TNRC6B
GH22F039958 1.6 FANTOM5 Ensembl ENCODE 13 +66.8 66838 4.5 HDGF ATF1 ZNF121 FOS JUNB NCOA1 REST TBX21 MBD2 SMARCA4 FAM83F GRAP2 ENTHD1 CACNA1I MIEF1 TNRC6B ENSG00000225528 GC22P039976
GH22F039956 1.4 FANTOM5 Ensembl ENCODE 13.8 +63.4 63393 0.8 HDGF ESRRA MXI1 TBL1XR1 EBF1 RELA EED ETV6 RCOR1 NR2F6 GRAP2 ENTHD1 FAM83F TNRC6B MIEF1 ENSG00000225528
GH22F039930 1.3 Ensembl ENCODE 12.1 +44.2 44225 15.7 PKNOX1 ARNT FEZF1 ZNF766 FOS ZNF263 JUNB REST TBX21 MEF2D ENSG00000225528 GRAP2 ENTHD1 FAM83F CACNA1I TAB1 TNRC6B
GH22F040007 1.1 Ensembl ENCODE 10.9 +115.3 115254 4.1 TBP PKNOX1 ZNF121 ZNF366 ELK1 RCOR1 EGR2 ZNF263 CEBPB SMARCA4 CACNA1I ENTHD1 GRAP2 TNRC6B FAM83F MIEF1 GC22M040842
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GRAP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GRAP2 Gene

Chromosome:
22
Start:
39,893,808 bp from pter
End:
39,973,721 bp from pter
Size:
79,914 bases
Orientation:
Plus strand

Genomic View for GRAP2 Gene

Genes around GRAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRAP2 Gene

Proteins for GRAP2 Gene

  • Protein details for GRAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75791-GRAP2_HUMAN
    Recommended name:
    GRB2-related adapter protein 2
    Protein Accession:
    O75791
    Secondary Accessions:
    • B7Z8I3
    • O43726
    • Q9NRB7

    Protein attributes for GRAP2 Gene

    Size:
    330 amino acids
    Molecular mass:
    37909 Da
    Quaternary structure:
    • Interacts with phosphorylated LIME1 upon TCR activation (By similarity). Interacts with phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB. Interacts with PTPN23.

    Alternative splice isoforms for GRAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRAP2 Gene

Post-translational modifications for GRAP2 Gene

  • Ubiquitination at Lys 141
  • Modification sites at PhosphoSitePlus

Other Protein References for GRAP2 Gene

Antibody Products

  • Abcam antibodies for GRAP2
  • Cloud-Clone Corp. Antibodies for GRAP2

No data available for DME Specific Peptides for GRAP2 Gene

Domains & Families for GRAP2 Gene

Gene Families for GRAP2 Gene

Protein Domains for GRAP2 Gene

Graphical View of Domain Structure for InterPro Entry

O75791

UniProtKB/Swiss-Prot:

GRAP2_HUMAN :
  • Contains 1 SH2 domain.
  • Belongs to the GRB2/sem-5/DRK family.
Domain:
  • Contains 1 SH2 domain.
  • Contains 2 SH3 domains.
Family:
  • Belongs to the GRB2/sem-5/DRK family.
genes like me logo Genes that share domains with GRAP2: view

Function for GRAP2 Gene

Molecular function for GRAP2 Gene

GENATLAS Biochemistry:
Grb2-related adaptor protein 2,expressed in thymus and spleen interacting with cKIT,EPOR,coupling tyrosine kinase to the RAS pathway
UniProtKB/Swiss-Prot Function:
Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.

Gene Ontology (GO) - Molecular Function for GRAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 9878555
GO:0005515 protein binding IPI 12359715
genes like me logo Genes that share ontologies with GRAP2: view
genes like me logo Genes that share phenotypes with GRAP2: view

Animal Models for GRAP2 Gene

MGI Knock Outs for GRAP2:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRAP2 Gene

Localization for GRAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRAP2 Gene

Nucleus. Cytoplasm. Endosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRAP2 gene
Compartment Confidence
nucleus 5
cytosol 5
endosome 5
plasma membrane 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GRAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 21179510
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 21179510
GO:0005768 endosome IEA,IDA 21179510
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with GRAP2: view

Pathways & Interactions for GRAP2 Gene

genes like me logo Genes that share pathways with GRAP2: view

Gene Ontology (GO) - Biological Process for GRAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007265 Ras protein signal transduction TAS 9878555
GO:0007267 cell-cell signaling TAS 9878555
GO:0009967 positive regulation of signal transduction IEA --
GO:0031295 T cell costimulation TAS --
GO:0038095 Fc-epsilon receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with GRAP2: view

No data available for SIGNOR curated interactions for GRAP2 Gene

Drugs & Compounds for GRAP2 Gene

(2) Drugs for GRAP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for GRAP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GRAP2: view

Transcripts for GRAP2 Gene

Unigene Clusters for GRAP2 Gene

GRB2-related adaptor protein 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRAP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1:
SP2: -

Relevant External Links for GRAP2 Gene

GeneLoc Exon Structure for
GRAP2
ECgene alternative splicing isoforms for
GRAP2

Expression for GRAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GRAP2 Gene

mRNA differential expression in normal tissues according to GTEx for GRAP2 Gene

This gene is overexpressed in Whole Blood (x20.5) and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for GRAP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.5), Tlymphocyte (19.4), and CD8 Tcells (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GRAP2 Gene



Protein tissue co-expression partners for GRAP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GRAP2 Gene:

GRAP2

SOURCE GeneReport for Unigene cluster for GRAP2 Gene:

Hs.517499
genes like me logo Genes that share expression patterns with GRAP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GRAP2 Gene

Orthologs for GRAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRAP2 34 35
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia GRAP2 34 35
  • 90.05 (n)
cow
(Bos Taurus)
Mammalia GRAP2 34 35
  • 86.81 (n)
rat
(Rattus norvegicus)
Mammalia Grap2 34
  • 83.28 (n)
mouse
(Mus musculus)
Mammalia Grap2 34 16 35
  • 83.02 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GRAP2 35
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRAP2 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRAP2 34 35
  • 68.82 (n)
lizard
(Anolis carolinensis)
Reptilia GRAP2 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grap2 34
  • 55.52 (n)
zebrafish
(Danio rerio)
Actinopterygii grap2b 34 35
  • 60.59 (n)
grap2a 35
  • 52 (a)
OneToMany
-- 34
fruit fly
(Drosophila melanogaster)
Insecta drk 35
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sem-5 35
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8309 35
  • 44 (a)
OneToMany
Species where no ortholog for GRAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRAP2 Gene

ENSEMBL:
Gene Tree for GRAP2 (if available)
TreeFam:
Gene Tree for GRAP2 (if available)

Paralogs for GRAP2 Gene

Variants for GRAP2 Gene

Sequence variations from dbSNP and Humsavar for GRAP2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs10483201 -- 39,913,326(+) ACCAG(A/G)TATGA intron-variant
rs10552410 -- 39,966,997(+) ACACT(-/CA)CACAC intron-variant
rs1060824 -- 39,971,301(+) CTTTT(C/T)TGCCC utr-variant-3-prime
rs107140 -- 39,938,923(+) CGGAC(A/G)AGCTG intron-variant
rs111312179 -- 39,937,600(+) CCAGA(A/G)TGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRAP2 Gene

Variant ID Type Subtype PubMed ID
esv3647768 CNV loss 21293372
nsv1131660 CNV deletion 24896259
nsv510808 CNV deletion 20534489
nsv834201 CNV gain 17160897
nsv979678 CNV duplication 23825009

Variation tolerance for GRAP2 Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRAP2 Gene

Disorders for GRAP2 Gene

Relevant External Links for GRAP2

Genetic Association Database (GAD)
GRAP2
Human Genome Epidemiology (HuGE) Navigator
GRAP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRAP2

No disorders were found for GRAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRAP2 Gene

Publications for GRAP2 Gene

  1. Molecular cloning and expression of human grap-2, a novel leukocyte- specific SH2- and SH3-containing adaptor-like protein that binds to gab-1. (PMID: 9878555) Qiu M. … Liu M. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 22 64
  2. Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling. (PMID: 10811803) Zhang W. … Samelson L.E. (J. Biol. Chem. 2000) 3 4 22 64
  3. Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT. (PMID: 10224278) Asada H. … Sugamura K. (J. Exp. Med. 1999) 2 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL. (PMID: 21179510) Tanase C.A. (PLoS ONE 2010) 3 4 64

Products for GRAP2 Gene

Sources for GRAP2 Gene

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