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Aliases for GRAP2 Gene

Aliases for GRAP2 Gene

  • GRB2-Related Adaptor Protein 2 2 3 5
  • Hematopoietic Cell-Associated Adapter Protein GrpL 3 4
  • Growth Factor Receptor-Binding Protein 3 4
  • SH3-SH2-SH3 Adapter Mona 3 4
  • Grf40 Adapter Protein 3 4
  • Adapter Protein GRID 3 4
  • GRB-2-Like Protein 3 4
  • Grf-40 3 4
  • GRB2L 3 4
  • GRBLG 3 4
  • GrbX 3 4
  • GADS 3 4
  • GRID 3 4
  • P38 3 4
  • Growth Factor Receptor-Bound Protein 2-Related Adaptor Protein 2 3
  • Hematopoietic Cell-Associated Adaptor Protein GRPL 3
  • GRB2-Related Protein With Insert Domain 3
  • SH3-SH2-SH3 Adaptor Molecule 3
  • Protein GADS 4
  • GRAP-2 3
  • Grf40 3
  • GRPL 3
  • Mona 3

External Ids for GRAP2 Gene

Previous GeneCards Identifiers for GRAP2 Gene

  • GC22P036911
  • GC22P038540
  • GC22P038621
  • GC22P040297
  • GC22P023272

Summaries for GRAP2 Gene

Entrez Gene Summary for GRAP2 Gene

  • This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

GeneCards Summary for GRAP2 Gene

GRAP2 (GRB2-Related Adaptor Protein 2) is a Protein Coding gene. Diseases associated with GRAP2 include Potter's Syndrome and Ovarian Carcinosarcoma. Among its related pathways are CTLA4 Signaling and Kit Receptor Signaling Pathway. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is GRAPL.

UniProtKB/Swiss-Prot for GRAP2 Gene

  • Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.

Gene Wiki entry for GRAP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRAP2 Gene

Genomics for GRAP2 Gene

Regulatory Elements for GRAP2 Gene

Enhancers for GRAP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GRAP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GRAP2 Gene

39,893,808 bp from pter
39,973,721 bp from pter
79,914 bases
Plus strand

Genomic View for GRAP2 Gene

Genes around GRAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRAP2 Gene

Proteins for GRAP2 Gene

  • Protein details for GRAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GRB2-related adapter protein 2
    Protein Accession:
    Secondary Accessions:
    • B7Z8I3
    • O43726
    • Q9NRB7

    Protein attributes for GRAP2 Gene

    330 amino acids
    Molecular mass:
    37909 Da
    Quaternary structure:
    • Interacts with phosphorylated LIME1 upon TCR activation (By similarity). Interacts with phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB. Interacts with PTPN23.

    Alternative splice isoforms for GRAP2 Gene


neXtProt entry for GRAP2 Gene

Proteomics data for GRAP2 Gene at MOPED

Post-translational modifications for GRAP2 Gene

  • Ubiquitination at Lys 141
  • Modification sites at PhosphoSitePlus

Other Protein References for GRAP2 Gene

Antibody Products

  • Abcam antibodies for GRAP2
  • Cloud-Clone Corp. Antibodies for GRAP2

No data available for DME Specific Peptides for GRAP2 Gene

Domains & Families for GRAP2 Gene

Gene Families for GRAP2 Gene

Protein Domains for GRAP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SH2 domain.
  • Belongs to the GRB2/sem-5/DRK family.
  • Contains 1 SH2 domain.
  • Contains 2 SH3 domains.
  • Belongs to the GRB2/sem-5/DRK family.
genes like me logo Genes that share domains with GRAP2: view

Function for GRAP2 Gene

Molecular function for GRAP2 Gene

GENATLAS Biochemistry:
Grb2-related adaptor protein 2,expressed in thymus and spleen interacting with cKIT,EPOR,coupling tyrosine kinase to the RAS pathway
UniProtKB/Swiss-Prot Function:
Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.
genes like me logo Genes that share phenotypes with GRAP2: view

Animal Models for GRAP2 Gene

MGI Knock Outs for GRAP2:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRAP2 Gene

Localization for GRAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRAP2 Gene

Nucleus. Cytoplasm. Endosome.

Subcellular locations from

Jensen Localization Image for GRAP2 Gene COMPARTMENTS Subcellular localization image for GRAP2 gene
Compartment Confidence
cytosol 5
endosome 5
nucleus 5
plasma membrane 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GRAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21179510
GO:0005768 endosome IDA 21179510
genes like me logo Genes that share ontologies with GRAP2: view

Pathways & Interactions for GRAP2 Gene

genes like me logo Genes that share pathways with GRAP2: view

Gene Ontology (GO) - Biological Process for GRAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0038095 Fc-epsilon receptor signaling pathway TAS --
GO:0045087 innate immune response TAS --
GO:0050852 T cell receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with GRAP2: view

No data available for SIGNOR curated interactions for GRAP2 Gene

Drugs & Compounds for GRAP2 Gene

(2) Drugs for GRAP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for GRAP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GRAP2: view

Transcripts for GRAP2 Gene

Unigene Clusters for GRAP2 Gene

GRB2-related adaptor protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRAP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP2: -

Relevant External Links for GRAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRAP2 Gene

mRNA expression in normal human tissues for GRAP2 Gene

mRNA differential expression in normal tissues according to GTEx for GRAP2 Gene

This gene is overexpressed in Whole Blood (x20.5) and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for GRAP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.5), Tlymphocyte (19.4), and CD8 Tcells (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GRAP2 Gene

SOURCE GeneReport for Unigene cluster for GRAP2 Gene Hs.517499

genes like me logo Genes that share expression patterns with GRAP2: view

Protein tissue co-expression partners for GRAP2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GRAP2 Gene

Orthologs for GRAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GRAP2 35
  • 86.81 (n)
  • 88.29 (a)
GRAP2 36
  • 88 (a)
(Canis familiaris)
Mammalia GRAP2 35
  • 90.05 (n)
  • 93.97 (a)
GRAP2 36
  • 93 (a)
(Mus musculus)
Mammalia Grap2 35
  • 83.02 (n)
  • 86.02 (a)
Grap2 16
Grap2 36
  • 88 (a)
(Pan troglodytes)
Mammalia GRAP2 35
  • 99.39 (n)
  • 99.7 (a)
GRAP2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Grap2 35
  • 83.28 (n)
  • 85.14 (a)
(Monodelphis domestica)
Mammalia GRAP2 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia GRAP2 36
  • 75 (a)
(Gallus gallus)
Aves GRAP2 35
  • 68.82 (n)
  • 67.35 (a)
GRAP2 36
  • 60 (a)
(Anolis carolinensis)
Reptilia GRAP2 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia grap2 35
  • 55.52 (n)
  • 50.5 (a)
(Danio rerio)
Actinopterygii -- 35
grap2b 35
  • 60.59 (n)
  • 54.24 (a)
grap2a 36
  • 52 (a)
grap2b 36
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta drk 36
  • 48 (a)
(Caenorhabditis elegans)
Secernentea sem-5 36
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8309 36
  • 44 (a)
Species with no ortholog for GRAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRAP2 Gene

Gene Tree for GRAP2 (if available)
Gene Tree for GRAP2 (if available)

Paralogs for GRAP2 Gene

Paralogs for GRAP2 Gene

genes like me logo Genes that share paralogs with GRAP2: view

Variants for GRAP2 Gene

Sequence variations from dbSNP and Humsavar for GRAP2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs12759 - 39,971,046(+) TGGGC(C/T)TCTTC reference, missense
rs80400 -- 39,955,454(+) CCTTC(C/T)CACCA intron-variant
rs80403 -- 39,918,048(+) GATTT(A/T)TCCTT intron-variant
rs107140 -- 39,938,923(+) CGGAC(A/G)AGCTG intron-variant
rs2267414 -- 39,910,650(+) GATCC(A/G)CCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRAP2 Gene

Variant ID Type Subtype PubMed ID
nsv510808 CNV Loss 20534489
nsv834201 CNV Gain 17160897

Variation tolerance for GRAP2 Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.72% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GRAP2 Gene

Disorders for GRAP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GRAP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
potter's syndrome
  • potter syndrome
ovarian carcinosarcoma
  • ovarian malignant mesodermal mixed tumor
- elite association - COSMIC cancer census association via MalaCards
Search GRAP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GRAP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GRAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRAP2 Gene

Publications for GRAP2 Gene

  1. Molecular cloning and expression of human grap-2, a novel leukocyte- specific SH2- and SH3-containing adaptor-like protein that binds to gab-1. (PMID: 9878555) Qiu M. … Liu M. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23 67
  2. Expression of the Grb2-related RET adapter protein Grap-2 in human medullary thyroid carcinoma. (PMID: 19027225) Ludwig L. … Karges W. (Cancer Lett. 2009) 3 23
  3. CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription. (PMID: 18295596) Schneider H. … Rudd C.E. (Biochem. Biophys. Res. Commun. 2008) 3 23
  4. Grb2 and Gads exhibit different interactions with CD28 and play distinct roles in CD28-mediated costimulation. (PMID: 16818765) Watanabe R. … Abe R. (J. Immunol. 2006) 3 23
  5. Expression of the Grb2-related protein of the lymphoid system in B cell subsets enhances B cell antigen receptor signaling through mitogen-activated protein kinase pathways. (PMID: 12496419) Yankee T.M. … Clark E.A. (J. Immunol. 2003) 3 23

Products for GRAP2 Gene

Sources for GRAP2 Gene