Aliases for GRAP2 Gene
External Ids for GRAP2 Gene
Previous GeneCards Identifiers for GRAP2 Gene
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
GeneCards Summary for GRAP2 Gene
GRAP2 (GRB2-Related Adaptor Protein 2) is a Protein Coding gene. Diseases associated with GRAP2 include multicentric osteolysis, nodulosis, and arthropathy and potter's syndrome. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is GRAPL.
UniProtKB/Swiss-Prot for GRAP2 Gene
Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc