Aliases for GRAP2 Gene
External Ids for GRAP2 Gene
Previous GeneCards Identifiers for GRAP2 Gene
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
GeneCards Summary for GRAP2 Gene
GRAP2 (GRB2-Related Adaptor Protein 2) is a Protein Coding gene. Diseases associated with GRAP2 include Ovarian Carcinosarcoma and Potter's Syndrome. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is GRB2.
UniProtKB/Swiss-Prot for GRAP2 Gene
Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.