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GRAP Gene

protein-coding   GIFtS: 59
GCID: GC17M018923

GRB2-Related Adaptor Protein

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
GRB2-Related Adaptor Protein1 2
GRB2-Related Adapter Protein2
Growth Factor Receptor-Bound Protein 2-Related Adaptor Protein2

External Ids:    HGNC: 45621   Entrez Gene: 107502   Ensembl: ENSG000001540167   OMIM: 6043305   UniProtKB: Q135883   

Export aliases for GRAP gene to outside databases

Previous GC identifers: GC17M019170 GC17M020585 GC17M018867 GC17M019124 GC17M018864 GC17M018491


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GRAP Gene:
This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which
contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for
stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL
oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless
homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic
tyrosine kinases to the Ras signaling pathway. (provided by RefSeq, Jul 2012)

GeneCards Summary for GRAP Gene:
GRAP (GRB2-related adaptor protein) is a protein-coding gene. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is GRAPL.

UniProtKB/Swiss-Prot: GRAP_HUMAN, Q13588
Function: Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway

Gene Wiki entry for GRAP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GRAP gene promoter:
         MEF-2A   AREB6   SRY   HTF   Sox9   aMEF-2   ITF-2   Tal-1beta   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRAP promoter sequence
   Search Chromatin IP Primers for GRAP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

GRAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRAP gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M018923:  view genomic region     (about GC identifiers)

Start:
18,923,986 bp from pter      End:
18,950,950 bp from pter
Size:
26,965 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GRAP_HUMAN, Q13588 (See protein sequence)
Recommended Name: GRB2-related adapter protein  
Size: 217 amino acids; 25337 Da
Subunit: Associates through its SH2 domain with ligand-activated receptors for stem cell factor (KIT) and
erythropoietin (EPOR). Also forms a stable complex with the Bcr-Abl oncoprotein. GRAP is associated with the Ras
guanine nucleotide exchange factor SOS1, primarily through its N-terminal SH3 domain. Interacts with
phosphorylated LAT upon TCR activation. Interacts with SHB

Explore the universe of human proteins at neXtProt for GRAP: NX_Q13588

Explore proteomics data for GRAP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys38
  • Modification sites at PhosphoSitePlus

  • See GRAP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006604.1  
    ENSEMBL proteins: 
     ENSP00000284154   ENSP00000459833   ENSP00000378997   ENSP00000464328  
    Reactome Protein details: Q13588

    GRAP Human Recombinant Protein Products:

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    Novus Biologicals GRAP Protein
    Novus Biologicals GRAP Lysates
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    Browse Proteins at Cloud-Clone Corp.

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    3 InterPro protein domains:
     IPR001452 SH3_domain
     IPR011511 SH3_2
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q13588

    ProtoNet protein and cluster: Q13588

    2 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature


    UniProtKB/Swiss-Prot: GRAP_HUMAN, Q13588
    Similarity: Belongs to the GRB2/sem-5/DRK family
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 2 SH3 domains


    Find genes that share domains with GRAP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRAP_HUMAN, Q13588
    Function: Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity TAS8647802
    GO:0005515protein binding ----
         
    Find genes that share ontologies with GRAP           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Grap):
     hematopoietic system  immune system 

    Find genes that share phenotypes with GRAP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Graptm1Gsf for GRAP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRAP
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRAP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GRAP

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate GRAP:
    hsa-miR-1182 hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidGRAP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GRAP

    Gene Editing
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS8647802
    GO:0005829cytosol TAS--

    Find genes that share ontologies with GRAP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GRAP About    
    See pathways by source

    SuperPathContained pathways About
    1PI-3K cascade
    Signaling by SCF-KIT0.72
    2Signaling by GPCR
    Signal Transduction0.58
    3Kit Receptor Signaling Pathway
    Kit Receptor Signaling Pathway0.37


    Find genes that share SuperPaths with GRAP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for GRAP
        Kit Receptor Signaling Pathway

    1 Reactome Pathway for GRAP
        Signaling by SCF-KIT


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GRAP
    Interactions:

        GeneGlobe Interaction Network for GRAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GRAP (Q135882, 3 ENSP000002841544) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SHC1P293532, 3, ENSP000004013034MINT-8032732 I2D: score=3 STRING: ENSP00000401303
    BCRP112742, 3, ENSP000003035074MINT-8026518 I2D: score=1 STRING: ENSP00000303507
    ARHGAP32A7KAX93, ENSP000003105614STRING: ENSP00000310561 I2D: score=2 
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    LCKP062393, ENSP000003378254I2D: score=2 STRING: ENSP00000337825
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007265Ras protein signal transduction TAS8647802
    GO:0007267cell-cell signaling TAS8647802
    GO:0009967positive regulation of signal transduction TAS8647802

    Find genes that share ontologies with GRAP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GRAP

    3 HMDB Compounds for GRAP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 Novoseek inferred chemical compound relationship for GRAP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 33.4 2 8647802 (1), 18339533 (1)



    Find genes that share compounds with GRAP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GRAP gene: 
    NM_006613.3  

    Unigene Cluster for GRAP:

    GRB2-related adaptor protein
    Hs.567416  [show with all ESTs]
    Unigene Representative Sequence: NM_006613
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284154(uc002guy.3) ENST00000573099 ENST00000395635 ENST00000583020
    ENST00000571380
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate GRAP:
    hsa-miR-1182 hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidGRAP 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GRAP
      QuantiTect SYBR Green Assays in human, mouse, rat GRAP
      QuantiFast Probe-based Assays in human, mouse, rat GRAP

    Additional mRNA sequence: 

    BC035856.1 BC063035.1 BT019981.1 CR541941.1 CR541966.1 U52518.1 

    12 DOTS entries:

    DT.400143  DT.423061  DT.100853419  DT.91857369  DT.100642363  DT.100831755  DT.92026222  DT.97784953 
    DT.97842428  DT.120954067  DT.120971530  DT.65284396 

    Selected AceView cDNA sequences (see all 88):

    AA312640 NM_006613 BC063035 AL040554 CR624975 BX457124 BQ062137 CR595033 
    BM457683 BX401444 CR600595 BQ059233 AI247233 BC035856 BQ057670 BX281266 
    BI821072 BM985084 CR541966 BQ064205 CR541941 BX342636 BF509642 AA766481 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GRAP    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:                                                                        
    SP2:                                      -                                 
    SP3:                                      -     -                           
    SP4:                                -     -     -                           


    ECgene alternative splicing isoforms for GRAP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GRAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGGCTCTT
    GRAP Expression
    About this image

    GRAP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GRAP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567416
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GRAP gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grap1 , 5 GRB2-related adaptor protein1, 5 87.4(n)1
    92.17(a)1
      11 (37.96 cM)5
    715201  NM_027817.31  NP_082093.11 
     616532655 
    chicken
    (Gallus gallus)
    Aves GRAP1 GRB2-related adaptor protein 77.31(n)
    78.87(a)
      416523  NM_001277553.1  NP_001264482.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    67(a)
    1 → many
    GL343618.1(349579-368900)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1001275981 uncharacterized LOC100127598 70.09(n)
    67.76(a)
      100127598  NM_001112957.1  NP_001106428.1 
    zebrafish
    (Danio rerio)
    Actinopterygii grapa1 GRB2-related adaptor protein a 63.38(n)
    61.03(a)
      553596  NM_001020573.1  NP_001018409.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta drk3 RAS protein signal transduction SH3/SH2
    adaptor more
    54(a)   2 50A13   --
    worm
    (Caenorhabditis elegans)
    Secernentea sem-53 C. elegans sem-5 51(a)   X(7995288-7996908)   --


    ENSEMBL Gene Tree for GRAP (if available)
    TreeFam Gene Tree for GRAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GRAP gene
    GRAPL2  NCK12  NCK22  GRAP22  GRB22  
    Selected SIMAP similar genes for GRAP using alignment to 4 protein entries:     GRAP_HUMAN (see all proteins) (see all similar genes):
    GRAPL    ITSN2    GRB2    GRAP2    ARHGEF7    ABL1
    SH3GL1    YES1    SH3GL2    FYN    HCK    CSK
    ABL2    BCR-ABL1 e19a2    NCKIPSD    BCR-ABL1    FGR    LCK

    Find genes that share paralogs with GRAP           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for GRAP
    PGOHUM00000245192 PGOHUM00000262498


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GRAP (see all 110)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1116361631,2
    C--18924644(+) CTGCCC/TGCCCC 1 -- ut311Minor allele frequency- T:0.50CSA 2
    rs1811710651,2
    --18924904(+) GGCCAC/GGGTTC 1 -- ut310--------
    rs1853354361,2
    --18924939(+) AAACCC/TGGGAG 1 -- ut310--------
    rs1881149631,2
    --18924986(+) AGGAGG/TTGGGC 1 -- ut310--------
    rs1471818921,2
    C--18924999(+) GGCCTC/TCACAG 1 -- ut310--------
    rs1137038561,2
    C,F--18925104(+) ACCTGA/GGCCAT 1 -- ut312Minor allele frequency- G:0.40CSA 5
    rs10574001,2
    C--18925125(-) GGCCGC/GTCTGC 1 -- ut31 ese32Minor allele frequency- G:0.00NA 4
    rs10573991,2
    C--18925148(-) AACGTG/AGGCTC 1 -- ut311Minor allele frequency- A:0.00NA 2
    rs1405078731,2
    --18925165(+) AAGGCC/TGTCCA 1 -- ut310--------
    rs1808460471,2
    --18925180(+) GCCCCA/GTGTGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for GRAP (18923986 - 18950950 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GRAP (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv907789CNV Loss21882294
    nsv907825CNV Loss21882294
    nsv907795CNV Loss21882294
    nsv833391CNV Loss17160897
    dgv3082n71CNV Loss21882294
    dgv3083n71CNV Loss21882294
    dgv3086n71CNV Gain21882294
    nsv907786CNV Gain21882294
    dgv3080n71CNV Gain21882294
    dgv3085n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604330    OMIM disorders: --


    Find genes that share disorders with GRAP           About GenesLikeMe

    Genetic Association Database (GAD): GRAP
    Human Genome Epidemiology (HuGE) Navigator: GRAP (4 documents)

    Export disorders for GRAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GRAP gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with GRAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway. (PubMed id 8647802)1, 2, 3, 9 Feng G.-S.... Ni J. (J. Biol. Chem. 1996)
    2. The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling. (PubMed id 8995379)1, 3, 9 TrA1b T....Shoelson S.E. (J. Biol. Chem. 1997)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Polymorphisms of four bone mineral density candidate genes in Chinese populations and comparison with other populations of different ethnicity. (PubMed id 12491092)1, 4 Lei S.F....Deng H.W. (J. Bone Miner. Metab. 2003)
    5. Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins. (PubMed id 9484780)1, 2 Welsh M.... Shoelson S.E. (Oncogene 1998)
    6. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. (PubMed id 9489702)1, 2 Zhang W.... Samelson L.E. (Cell 1998)
    7. Quantitative mass spectrometry of diabetic kidney tubules identifies GRAP as a novel regulator of TGF-beta signaling. (PubMed id 19836472)1, 9 Cummins T.D....Powell D.W. (Biochim. Biophys. Acta 2010)
    8. CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription. (PubMed id 18295596)1, 9 Schneider H. and Rudd C.E. (Biochem. Biophys. Res. Commun. 2008)
    9. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
    10. Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with SjAPgren's syndrome. (PubMed id 15174222)1 Shiraiwa H....Sawada S. (J. Int. Med. Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10750 HGNC: 4562 AceView: GRAP Ensembl:ENSG00000154016 euGenes: HUgn10750
    ECgene: GRAP H-InvDB: GRAP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GRAP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GRAP gene:
    Search GeneIP for patents involving GRAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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