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Aliases for GRAP Gene

Aliases for GRAP Gene

  • GRB2-Related Adaptor Protein 2 3 5

External Ids for GRAP Gene

Previous GeneCards Identifiers for GRAP Gene

  • GC17M019170
  • GC17M020585
  • GC17M018867
  • GC17M019124
  • GC17M018864
  • GC17M018923
  • GC17M018491
  • GC17M019021

Summaries for GRAP Gene

Entrez Gene Summary for GRAP Gene

  • This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012]

GeneCards Summary for GRAP Gene

GRAP (GRB2-Related Adaptor Protein) is a Protein Coding gene. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Kit Receptor Signaling Pathway. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is GRAPL.

UniProtKB/Swiss-Prot for GRAP Gene

  • Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.

Gene Wiki entry for GRAP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRAP Gene

Genomics for GRAP Gene

Regulatory Elements for GRAP Gene

Enhancers for GRAP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GRAP on UCSC Golden Path with GeneCards custom track

Promoters for GRAP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GRAP on UCSC Golden Path with GeneCards custom track

Genomic Location for GRAP Gene

19,020,673 bp from pter
19,047,637 bp from pter
26,965 bases
Minus strand

Genomic View for GRAP Gene

Genes around GRAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRAP Gene

Proteins for GRAP Gene

  • Protein details for GRAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GRB2-related adapter protein
    Protein Accession:

    Protein attributes for GRAP Gene

    217 amino acids
    Molecular mass:
    25337 Da
    Quaternary structure:
    • Associates through its SH2 domain with ligand-activated receptors for stem cell factor (KIT) and erythropoietin (EPOR). Also forms a stable complex with the Bcr-Abl oncoprotein. GRAP is associated with the Ras guanine nucleotide exchange factor SOS1, primarily through its N-terminal SH3 domain. Interacts with phosphorylated LAT upon TCR activation. Interacts with SHB.

neXtProt entry for GRAP Gene

Proteomics data for GRAP Gene at MOPED

Post-translational modifications for GRAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GRAP Gene

No data available for DME Specific Peptides for GRAP Gene

Domains & Families for GRAP Gene

Gene Families for GRAP Gene

Protein Domains for GRAP Gene

Suggested Antigen Peptide Sequences for GRAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SH2 domain.
  • Belongs to the GRB2/sem-5/DRK family.
  • Contains 1 SH2 domain.
  • Contains 2 SH3 domains.
  • Belongs to the GRB2/sem-5/DRK family.
genes like me logo Genes that share domains with GRAP: view

Function for GRAP Gene

Molecular function for GRAP Gene

UniProtKB/Swiss-Prot Function:
Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.
genes like me logo Genes that share phenotypes with GRAP: view

Animal Models for GRAP Gene

MGI Knock Outs for GRAP:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRAP Gene

Localization for GRAP Gene

Subcellular locations from

Jensen Localization Image for GRAP Gene COMPARTMENTS Subcellular localization image for GRAP gene
Compartment Confidence
cytosol 5
nucleus 2
cytoskeleton 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GRAP Gene

Pathways & Interactions for GRAP Gene

genes like me logo Genes that share pathways with GRAP: view

Pathways by source for GRAP Gene

1 BioSystems pathway for GRAP Gene
2 Reactome pathways for GRAP Gene

SIGNOR curated interactions for GRAP Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GRAP Gene


Drugs & Compounds for GRAP Gene

(4) Drugs for GRAP Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GRAP: view

Transcripts for GRAP Gene

Unigene Clusters for GRAP Gene

GRB2-related adaptor protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRAP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP2: -
SP3: - -
SP4: - - -

Relevant External Links for GRAP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRAP Gene

mRNA expression in normal human tissues for GRAP Gene

mRNA differential expression in normal tissues according to GTEx for GRAP Gene

This gene is overexpressed in Spleen (x7.7) and Whole Blood (x5.0).

Protein differential expression in normal tissues from HIPED for GRAP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.5), Tlymphocyte (20.6), and Monocytes (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GRAP Gene

SOURCE GeneReport for Unigene cluster for GRAP Gene Hs.567416

genes like me logo Genes that share expression patterns with GRAP: view

Protein tissue co-expression partners for GRAP Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GRAP Gene

Orthologs for GRAP Gene

This gene was present in the common ancestor of animals.

Orthologs for GRAP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GRAP 35
  • 89.25 (n)
  • 91.24 (a)
(Canis familiaris)
Mammalia GRAP 35
  • 90.78 (n)
  • 93.09 (a)
(Mus musculus)
Mammalia Grap 35
  • 87.4 (n)
  • 92.17 (a)
Grap 16
Grap 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Grap 35
  • 86.18 (n)
  • 90.78 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
(Gallus gallus)
Aves GRAP 35
  • 77.31 (n)
  • 78.87 (a)
  • 76 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100127598 35
  • 70.09 (n)
  • 67.76 (a)
(Danio rerio)
Actinopterygii grapa 35
  • 63.38 (n)
  • 61.03 (a)
grapa 36
  • 59 (a)
grapb 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta drk 37
  • 54 (a)
drk 36
  • 55 (a)
(Caenorhabditis elegans)
Secernentea sem-5 37
  • 51 (a)
sem-5 36
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8309 36
  • 48 (a)
Species with no ortholog for GRAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRAP Gene

Gene Tree for GRAP (if available)
Gene Tree for GRAP (if available)

Paralogs for GRAP Gene

Paralogs for GRAP Gene Pseudogenes for GRAP Gene

genes like me logo Genes that share paralogs with GRAP: view

Variants for GRAP Gene

Sequence variations from dbSNP and Humsavar for GRAP Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1035276 -- 19,037,583(+) tcccc(A/C)tgaat intron-variant
rs1634412 -- 19,027,484(-) GTGTG(C/T)GCGCG intron-variant
rs1057399 -- 19,021,835(+) AACGT(A/C/G/T)GGCTC reference, synonymous-codon, utr-variant-3-prime
rs1057400 -- 19,021,812(+) GGCCG(C/G)TCTGC utr-variant-3-prime
rs2472705 -- 19,032,975(-) TGTGT(A/G)CTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRAP Gene

Variant ID Type Subtype PubMed ID
nsv9504 CNV Gain+Loss 18304495
nsv907783 CNV Gain 21882294
dgv3080n71 CNV Gain 21882294
nsv833391 CNV Loss 17160897
esv33572 CNV Gain 17666407
nsv907786 CNV Gain 21882294
nsv428336 CNV Gain+Loss 18775914
dgv933e1 CNV Complex 17122850
dgv3081n71 CNV Gain 21882294
nsv907789 CNV Loss 21882294
dgv3082n71 CNV Loss 21882294
nsv907795 CNV Loss 21882294
nsv7291 OTHER Inversion 18451855
dgv3083n71 CNV Loss 21882294
dgv3084n71 CNV Gain+Loss 21882294
dgv3085n71 CNV Gain 21882294
nsv907805 CNV Gain+Loss 21882294
dgv3086n71 CNV Gain 21882294
esv25927 CNV Gain+Loss 19812545
dgv3087n71 CNV Gain+Loss 21882294
nsv907825 CNV Loss 21882294

Variation tolerance for GRAP Gene

Gene Damage Index Score: 0.44; 9.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GRAP Gene

Disorders for GRAP Gene

Relevant External Links for GRAP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GRAP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRAP Gene

Publications for GRAP Gene

  1. Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway. (PMID: 8647802) Feng G.-S. … Ni J. (J. Biol. Chem. 1996) 2 3 4 23 67
  2. The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling. (PMID: 8995379) TrA1b T. … Shoelson S.E. (J. Biol. Chem. 1997) 2 3 23
  3. Quantitative mass spectrometry of diabetic kidney tubules identifies GRAP as a novel regulator of TGF-beta signaling. (PMID: 19836472) Cummins T.D. … Powell D.W. (Biochim. Biophys. Acta 2010) 3 23
  4. CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription. (PMID: 18295596) Schneider H. … Rudd C.E. (Biochem. Biophys. Res. Commun. 2008) 3 23
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for GRAP Gene

Sources for GRAP Gene