External Ids for GRAP Gene
Previous GeneCards Identifiers for GRAP Gene
This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012]
GeneCards Summary for GRAP Gene
GRAP (GRB2-Related Adaptor Protein) is a Protein Coding gene. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Kit Receptor Signaling Pathway. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is GRAPL.
UniProtKB/Swiss-Prot for GRAP Gene
Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.