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Aliases for GRAP Gene

Aliases for GRAP Gene

  • GRB2-Related Adaptor Protein 2 3

External Ids for GRAP Gene

Previous GeneCards Identifiers for GRAP Gene

  • GC17M019170
  • GC17M020585
  • GC17M018867
  • GC17M019124
  • GC17M018864
  • GC17M018923
  • GC17M018491

Summaries for GRAP Gene

Entrez Gene Summary for GRAP Gene

  • This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012]

GeneCards Summary for GRAP Gene

GRAP (GRB2-Related Adaptor Protein) is a Protein Coding gene. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is GRAPL.

UniProtKB/Swiss-Prot for GRAP Gene

  • Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway

Gene Wiki entry for GRAP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRAP Gene

Genomics for GRAP Gene

Regulatory Elements for GRAP Gene

Genomic Location for GRAP Gene

Start:
19,020,656 bp from pter
End:
19,047,637 bp from pter
Size:
26,982 bases
Orientation:
Minus strand

Genomic View for GRAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRAP Gene

Proteins for GRAP Gene

  • Protein details for GRAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13588-GRAP_HUMAN
    Recommended name:
    GRB2-related adapter protein
    Protein Accession:
    Q13588
    Secondary Accessions:

    Protein attributes for GRAP Gene

    Size:
    217 amino acids
    Molecular mass:
    25337 Da
    Quaternary structure:
    • Associates through its SH2 domain with ligand-activated receptors for stem cell factor (KIT) and erythropoietin (EPOR). Also forms a stable complex with the Bcr-Abl oncoprotein. GRAP is associated with the Ras guanine nucleotide exchange factor SOS1, primarily through its N-terminal SH3 domain. Interacts with phosphorylated LAT upon TCR activation. Interacts with SHB.

neXtProt entry for GRAP Gene

Proteomics data for GRAP Gene at MOPED

Post-translational modifications for GRAP Gene

  • Ubiquitination at Lys38
  • Modification sites at PhosphoSitePlus

Other Protein References for GRAP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GRAP Gene

Domains for GRAP Gene

Gene Families for GRAP Gene

HGNC:
  • SH2D :SH2 domain containing

Protein Domains for GRAP Gene

Suggested Antigen Peptide Sequences for GRAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13588

UniProtKB/Swiss-Prot:

GRAP_HUMAN :
  • Q13588
Domain:
  • Contains 1 SH2 domain.
  • Contains 2 SH3 domains.
Family:
  • Belongs to the GRB2/sem-5/DRK family.
genes like me logo Genes that share domains with GRAP: view

Function for GRAP Gene

Molecular function for GRAP Gene

UniProtKB/Swiss-Prot Function:
Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway

Gene Ontology (GO) - Molecular Function for GRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 8647802
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GRAP: view

Phenotypes for GRAP Gene

genes like me logo Genes that share phenotypes with GRAP: view

Animal Models for GRAP Gene

MGI Knock Outs for GRAP:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRAP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GRAP Gene

Localization for GRAP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRAP Gene COMPARTMENTS Subcellular localization image for GRAP gene
Compartment Confidence
cytosol 4
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 8647802
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with GRAP: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GRAP Gene

Pathways for GRAP Gene

genes like me logo Genes that share pathways with GRAP: view

Pathways by source for GRAP Gene

1 BioSystems pathway for GRAP Gene
2 Reactome pathways for GRAP Gene

Gene Ontology (GO) - Biological Process for GRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007265 Ras protein signal transduction TAS 8647802
GO:0007267 cell-cell signaling TAS 8647802
GO:0009967 positive regulation of signal transduction TAS 8647802
genes like me logo Genes that share ontologies with GRAP: view

Compounds for GRAP Gene

(3) HMDB Compounds for GRAP Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1

(1) Novoseek inferred chemical compound relationships for GRAP Gene

Compound -log(P) Hits PubMed IDs
tyrosine 33.4 2
genes like me logo Genes that share compounds with GRAP: view

Transcripts for GRAP Gene

Unigene Clusters for GRAP Gene

GRB2-related adaptor protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRAP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRAP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1:
SP2: -
SP3: - -
SP4: - - -

Relevant External Links for GRAP Gene

GeneLoc Exon Structure for
GRAP
ECgene alternative splicing isoforms for
GRAP

Expression for GRAP Gene

mRNA expression in normal human tissues for GRAP Gene

mRNA differential expression in normal tissues according to GTEx for GRAP Gene

This gene is overexpressed in Spleen (7.7) and Whole Blood (5.0).

Protein differential expression in normal tissues for GRAP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.5), Tlymphocyte (20.6), and Monocytes (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GRAP Gene

SOURCE GeneReport for Unigene cluster for GRAP Gene Hs.567416

genes like me logo Genes that share expressions with GRAP: view

Expression partners for GRAP Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GRAP Gene

Orthologs for GRAP Gene

This gene was present in the common ancestor of animals.

Orthologs for GRAP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GRAP 35
  • 89.25 (n)
  • 91.24 (a)
dog
(Canis familiaris)
Mammalia GRAP 35
  • 90.78 (n)
  • 93.09 (a)
mouse
(Mus musculus)
Mammalia Grap 35
  • 87.4 (n)
  • 92.17 (a)
Grap 16
Grap 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grap 35
  • 86.18 (n)
  • 90.78 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
OneToMany
chicken
(Gallus gallus)
Aves GRAP 35
  • 77.31 (n)
  • 78.87 (a)
GRAP 36
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 67 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100127598 35
  • 70.09 (n)
  • 67.76 (a)
zebrafish
(Danio rerio)
Actinopterygii grapa 35
  • 63.38 (n)
  • 61.03 (a)
grapa 36
  • 59 (a)
ManyToMany
grapb 36
  • 59 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta drk 37
  • 54 (a)
drk 36
  • 55 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sem-5 37
  • 51 (a)
sem-5 36
  • 48 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8309 36
  • 48 (a)
OneToMany
Species with no ortholog for GRAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRAP Gene

ENSEMBL:
Gene Tree for GRAP (if available)
TreeFam:
Gene Tree for GRAP (if available)

Paralogs for GRAP Gene

Paralogs for GRAP Gene

Pseudogenes.org Pseudogenes for GRAP Gene

genes like me logo Genes that share paralogs with GRAP: view

Variants for GRAP Gene

Sequence variations from dbSNP and Humsavar for GRAP Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1057399 -- 19,021,835(-) AACGT(A/G)GGCTC utr-variant-3-prime, synonymous-codon, reference
rs1057400 -- 19,021,812(+) GGCCG(C/G)TCTGC utr-variant-3-prime
rs1634412 -- 19,027,484(-) GTGTG(C/T)GCGCG intron-variant
rs2074269 -- 19,031,506(-) CCCCC(G/T)GCCCA intron-variant
rs2074277 -- 19,023,630(-) GGGGT(C/T)GGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRAP Gene

Variant ID Type Subtype PubMed ID
nsv9504 CNV Gain+Loss 18304495
nsv907783 CNV Gain 21882294
dgv3080n71 CNV Gain 21882294
nsv833391 CNV Loss 17160897
esv33572 CNV Gain 17666407
nsv907786 CNV Gain 21882294
nsv428336 CNV Gain+Loss 18775914
dgv933e1 CNV Complex 17122850
dgv3081n71 CNV Gain 21882294
nsv907789 CNV Loss 21882294
dgv3082n71 CNV Loss 21882294
nsv907795 CNV Loss 21882294
nsv7291 OTHER Inversion 18451855
dgv3083n71 CNV Loss 21882294
dgv3084n71 CNV Gain+Loss 21882294
dgv3085n71 CNV Gain 21882294
nsv907805 CNV Gain+Loss 21882294
dgv3086n71 CNV Gain 21882294
esv25927 CNV Gain+Loss 19812545
dgv3087n71 CNV Gain+Loss 21882294
nsv907825 CNV Loss 21882294

Relevant External Links for GRAP Gene

HapMap Linkage Disequilibrium report
GRAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRAP Gene

Disorders for GRAP Gene

Relevant External Links for GRAP

Genetic Association Database (GAD)
GRAP
Human Genome Epidemiology (HuGE) Navigator
GRAP

No disorders were found for GRAP Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for GRAP Gene

Publications for GRAP Gene

  1. Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway. (PMID: 8647802) Feng G.-S. … Ni J. (J. Biol. Chem. 1996) 2 3 4 23
  2. The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling. (PMID: 8995379) TrA1b T. … Shoelson S.E. (J. Biol. Chem. 1997) 2 3 23
  3. Quantitative mass spectrometry of diabetic kidney tubules identifies GRAP as a novel regulator of TGF-beta signaling. (PMID: 19836472) Cummins T.D. … Powell D.W. (Biochim. Biophys. Acta 2010) 3 23
  4. Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins. (PMID: 9484780) Welsh M. … Shoelson S.E. (Oncogene 1998) 3 4
  5. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. (PMID: 9489702) Zhang W. … Samelson L.E. (Cell 1998) 3 4

Products for GRAP Gene

Sources for GRAP Gene

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