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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GRAP Gene

protein-coding GIFtS: 59
GCID: GC17M018923

GRB2-related adaptor protein

Explore 8 diseases affiliated with
GRAP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
GRB2-Related Adaptor Protein¹ ²
GRB2-Related Adapter Protein²
Growth Factor Receptor-Bound Protein 2-Related Adaptor Protein²

External Ids:	HGNC: 4562¹	Entrez Gene: 10750²	Ensembl: ENSG00000154016⁷	OMIM: 604330⁵	UniProtKB: Q13588³

Export aliases for GRAP gene to outside databases

Previous GC identifers: GC17M019170 GC17M020585 GC17M018867 GC17M019124 GC17M018864 GC17M018491

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GRAP:

This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains

an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell

factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This

protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its

N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras

signaling pathway. (provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: GRAP_HUMAN, Q13588

Function: Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway

Gene Wiki entry for GRAP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GRAP gene promoter:
MEF-2A AREB6 SRY HTF Sox9 aMEF-2 ITF-2 Tal-1beta GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GRAP promoter sequence

Search SABiosciences Chromatin IP Primers for GRAP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRAP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p11.2

GRAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRAP gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M018923: view genomic region (about GC identifiers)

Start:	18,923,986 bp from pter	End:	18,950,950 bp from pter
Size:	26,965 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GRAP_HUMAN, Q13588 (See protein sequence)

Recommended Name: GRB2-related adapter protein

Size: 217 amino acids; 25337 Da

Subunit: Associates through its SH2 domain with ligand-activated receptors for stem cell factor (KIT) and

erythropoietin (EPOR). Also forms a stable complex with the Bcr-Abl oncoprotein. GRAP is associated with the Ras

guanine nucleotide exchange factor SOS1, primarily through its N-terminal SH3 domain. Interacts with phosphorylated

LAT upon TCR activation. Interacts with SHB

Explore the universe of human proteins at neXtProt for GRAP: NX_Q13588

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13588

GRAP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006604.1

ENSEMBL proteins:

ENSP00000284154 ENSP00000459833 ENSP00000378997 ENSP00000464328

Reactome Protein details: Q13588
Human Recombinant Protein Products for GRAP:

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	Novus Biologicals GRAP Protein Novus Biologicals GRAP Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	8647802
GO:0005829	cytosol	TAS	--

GRAP for ontologies About GeneDecksing

GRAP Antibody Products:

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	Abcam antibodies for GRAP
	Browse Antibodies at Uscn
	ThermoFisher Antibody for GRAP

Assay Products for GRAP:

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	GenScript Custom Assay Services for GRAP
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GRAP for domains About GeneDecksing

4 InterPro domains/families:

IPR000108 p67phox

IPR001452 SH3_domain

IPR011511 SH3_2

IPR000980 SH2

Graphical View of Domain Structure for InterPro Entry Q13588

ProtoNet protein and cluster: Q13588

2 Blocks protein families:

IPB000980 SH2 domain signature

IPB001452 SH3 domain signature

UniProtKB/Swiss-Prot: GRAP_HUMAN, Q13588

Similarity: Belongs to the GRB2/sem-5/DRK family

Similarity: Contains 1 SH2 domain

Similarity: Contains 2 SH3 domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: GRAP_HUMAN, Q13588

Function: Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005070	SH3/SH2 adaptor activity	TAS	8647802

GRAP for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Grap):

cellular

hematopoietic system

immune system

GRAP for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Grap^tm1Gsf for GRAP

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for GRAP

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GRAP
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate GRAP:
		hsa-miR-1182 hsa-miR-3909
		SwitchGear 3'UTR luciferase reporter plasmid: GRAP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GRAP (see all 7) OriGene shRNA RFP: GRAP OriGene siRNA: GRAP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRAP
		Sirion Biotech Custom design and validation of potent shRNA sequences against GRAP

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for GRAP
			Sirion Biotech Customized adenovirus for overexpression of GRAP Sirion Biotech Customized adenovirus for potent knockdown of GRAP

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRAP (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRAP OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GRAP (NM_004810)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRAP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRAP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GRAP
		Search LifeMap BioReagents cell lines for GRAP
		Sirion Biotech Customized stable knockdown cell line services for GRAP Sirion Biotech Customized inducible knockdown cell line services for GRAP Sirion Biotech Customized stable overexpressing cell line services for GRAP Sirion Biotech Customized inducible overexpressing cell line services for GRAP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRAP

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PIP3 activates AKT signaling

Signaling by SCF-KIT

0.72

Signaling by GPCR

Signal Transduction

0.56

Signaling events mediated by Stem cell factor receptor (c-Kit)

Kit Receptor Signaling Pathway

0.37

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for GRAP

Kit Receptor Signaling Pathway

2 Reactome Pathways for GRAP

	Signal Transduction
	Signaling by SCF-KIT

GRAP for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GRAP

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

5/21 Interacting proteins for GRAP (Q13588^{2, 3} ENSP00000284154⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SHC1	P29353²^,³, ENSP00000401303⁴	MINT-8032732 I2D: score=3 STRING: ENSP00000401303
BCR	P11274²^,³, ENSP00000303507⁴	MINT-8026518 I2D: score=1 STRING: ENSP00000303507
ARHGAP32	A7KAX9³, ENSP00000310561⁴	STRING: ENSP00000310561 I2D: score=2
FYN	P06241³, ENSP00000357656⁴	I2D: score=2 STRING: ENSP00000357656
LCK	P06239³, ENSP00000337825⁴	I2D: score=2 STRING: ENSP00000337825

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007265	Ras protein signal transduction	TAS	8647802
GO:0007267	cell-cell signaling	TAS	8647802

GRAP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GRAP for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GRAP

3 HMDB Compounds for GRAP About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

1 Novoseek chemical compound relationship for GRAP gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	33.4	2	8647802 (1), 18339533 (1)

Search CenterWatch for drugs/clinical trials and news about GRAP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GRAP gene:

NM_006613.3

Unigene Cluster for GRAP:

GRB2-related adaptor protein

Hs.567416 [show with all ESTs]

Unigene Representative Sequence: NM_006613

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000284154(uc002guy.3) ENST00000573099 ENST00000395635 ENST00000583020

ENST00000571380

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GRAP
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate GRAP:
		hsa-miR-1182 hsa-miR-3909
		SwitchGear 3'UTR luciferase reporter plasmid: GRAP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GRAP (see all 7) OriGene shRNA RFP: GRAP OriGene siRNA: GRAP
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		Sirion Biotech Custom design and validation of potent shRNA sequences against GRAP

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRAP (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRAP OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GRAP (NM_004810)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRAP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRAP

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GRAP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat GRAP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRAP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRAP

Additional cDNA sequence:

BC035856.1 BC063035.1 BT019981.1 CR541941.1 CR541966.1 U52518.1

12 DOTS entries:

DT.400143 DT.423061 DT.100853419 DT.91857369 DT.100642363 DT.100831755 DT.92026222 DT.97784953

DT.97842428 DT.120954067 DT.120971530 DT.65284396

24/88 AceView cDNA sequences (see all 88):

BI821072 BX457124 BX401444 NM_006613 AI247233 AL040554 CR541941 BC035856

CR600595 BC063035 BX281266 BQ062137 BM985084 BQ057670 BQ059233 CR615744

AA312640 BM457683 CR595033 BF509642 CR541966 CR624975 AA766481 BQ064205

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for GRAP About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	·	6d
SP1:
SP2:													-
SP3:													-		-
SP4:											-		-		-

ECgene alternative splicing isoforms for GRAP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GRAP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGGGCTCTT

About this image

GRAP expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GRAP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GRAP

SOURCE GeneReport for Unigene cluster: Hs.567416

SABiosciences Custom PCR Arrays for GRAP

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GRAP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat GRAP
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRAP

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRAP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for GRAP gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	GRAP¹	GRB2-related adaptor protein	77.46(n) 78.87(a)		416523 XM_414827.3 XP_414827.2
lizard (Anolis carolinensis)	Reptilia	--	--	67(a)	1 → many	GL343618.1(351951-368740)
zebrafish (Danio rerio)	Actinopterygii	grapa¹	GRB2-related adaptor protein a	63.22(n) 61.03(a)		553596 NM_001020573.1 NP_001018409.1
fruit fly (Drosophila melanogaster)	Insecta	drk³	RAS protein signal transduction SH3/SH2 adaptor more	54(a)		2 50A13 --
worm (Caenorhabditis elegans)	Secernentea	sem-5³	C. elegans sem-5	51(a)		X(7995288-7996908) --

ENSEMBL Gene Tree for GRAP (if available)
TreeFam Gene Tree for GRAP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GRAP gene

GRAPL² NCK1² NCK2² GRAP2² GRB2²

18/22 SIMAP similar genes for GRAP using alignment to 4 protein entries: GRAP_HUMAN (see all proteins) (see all similar genes):

GRAPL ITSN2 GRB2 GRAP2 ARHGEF7 ABL1

SH3GL1 YES1 SH3GL2 FYN HCK CSK

ABL2 BCR-ABL1 e19a2 NCKIPSD BCR-ABL1 FGR LCK

GRAP for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for GRAP
PGOHUM00000245192 PGOHUM00000262498

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1624825^1,2	C,F,A,H	--	18923818(-)	`GGGGCC/TTCGGG`	6	--	ut3¹ ds500¹ nc-transcript-variant		16		MN NS EA NA	2038
rs141856816^1,2		--	18923861(+)	`CAGCTC/TGGTGC`	6	--	nc-transcript-variantut3¹ ds500¹		0	--	--	--	--
rs192961679^1,2		--	18923862(+)	`AGCTCA/GGTGCC`	6	--	nc-transcript-variantut3¹ ds500¹		0	--	--	--	--
rs185228977^1,2		--	18923870(+)	`GCCCAA/CGAACT`	6	--	ds500¹ ut3¹ nc-transcript-variant		0	--	--	--	--
rs56745876^1,2	F	--	18923892(+)	`CAAAGC/TGGGAG`	6	--	nc-transcript-variantut3¹ ds500¹		1		WA	118
rs188747641^1,2		--	18923998(+)	`CGGACA/GTCCTG`	6	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs11867753^1,2	C,F,H	--	18924120(+)	`CCCCAC/TATGCC`	6	--	ds500¹ ut3¹		7		NS EA WA NA	540
rs1621499^1,2	C,F,A,H	--	18924188(-)	`GGAGCC/TGGTGG`	6	--	ds500¹ ut3¹		15		NS EA NA WA CSA	2278
rs9896426^1,2	C,A	--	18924345(+)	`TGATCA/GTGGCA`	6	--	ut3¹ ds500¹		1		NA	2
rs143618306^1,2		--	18924389(+)	`GGGCCA/GTGCCC`	6	--	ds500¹ ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GRAP (18923986 - 18950950 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for GRAP
9 CNVs: 30808 4025 72814 72817 72816 7145 88374 77543 32155
1 Inversion: 37187

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GRAP

DNA2.0 Custom Variant and Variant Library Synthesis for GRAP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GRAP for disorders           About GeneDecksing

OMIM gene information: 604330    OMIM disorders: --

8 diseases for GRAP:    About MalaCards

urethral stricture phimosis urethritis hypospadias

sjogren's syndrome hepatocellular carcinoma carcinoma neuronitis

Genetic Association Database (GAD): GRAP
Human Genome Epidemiology (HuGE) Navigator: GRAP (4 documents)

Export disorders for GRAP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for GRAP gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with GRAP)

Utopia: connect your pdf to the dynamic
world of online information

Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway. (PubMed id 8647802)^{1, 2, 3, 9} Feng G.-S.... Ni J. (1996)
The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling. (PubMed id 8995379)^{1, 3, 9} Trub T....Shoelson S.E. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Polymorphisms of four bone mineral density candidate genes in Chinese populations and comparison with other populations of different ethnicity. (PubMed id 12491092)^{1, 4} Lei S.F....Deng H.W. (2003)
Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins. (PubMed id 9484780)^{1, 2} Welsh M.... Shoelson S.E. (1998)
LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. (PubMed id 9489702)^{1, 2} Zhang W.... Samelson L.E. (1998)
Quantitative mass spectrometry of diabetic kidney tub ules identifies GRAP as a novel regulator of TGF-beta signaling. (PubMed id 19836472)^{1, 9} Cummins T.D....Powell D.W. (2010)
CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription. (PubMed id 18295596)^{1, 9} Schneider H. and Rudd C.E. (2008)
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)² Zody M.C.... Nusbaum C. (2006)
Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sjogren's syndrome. (PubMed id 15174222)¹ Shiraiwa H....Sawada S. (2004)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10750	HGNC: 4562	AceView: GRAP	Ensembl:ENSG00000154016	euGenes: HUgn10750
ECgene: GRAP	H-InvDB: GRAP

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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PharmGKB entry for GRAP	Pharmacogenomics, SNPs, Pathways

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