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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GRAP Gene

protein-coding   GIFtS: 59
GCID: GC17M018923

GRB2-Related Adaptor Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
GRB2-Related Adaptor Protein1 2
GRB2-Related Adapter Protein2
Growth Factor Receptor-Bound Protein 2-Related Adaptor Protein2

External Ids:    HGNC: 45621   Entrez Gene: 107502   Ensembl: ENSG000001540167   OMIM: 6043305   UniProtKB: Q135883   

Export aliases for GRAP gene to outside databases

Previous GC identifers: GC17M019170 GC17M020585 GC17M018867 GC17M019124 GC17M018864 GC17M018491


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GRAP Gene:
This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which
contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for
stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL
oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless
homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic
tyrosine kinases to the Ras signaling pathway. (provided by RefSeq, Jul 2012)

GeneCards Summary for GRAP Gene: 
GRAP (GRB2-related adaptor protein) is a protein-coding gene. Diseases associated with GRAP include urethral stricture, and phimosis, and among its related super-pathways are PIP3 activates AKT signaling and Signaling by GPCR. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is GRAPL.

UniProtKB/Swiss-Prot: GRAP_HUMAN, Q13588
Function: Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway

Gene Wiki entry for GRAP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GRAP gene promoter:
         MEF-2A   AREB6   SRY   HTF   Sox9   aMEF-2   ITF-2   Tal-1beta   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRAP promoter sequence
   Search SABiosciences Chromatin IP Primers for GRAP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

GRAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRAP gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M018923:  view genomic region     (about GC identifiers)

Start:
18,923,986 bp from pter      End:
18,950,950 bp from pter
Size:
26,965 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GRAP_HUMAN, Q13588 (See protein sequence)
Recommended Name: GRB2-related adapter protein  
Size: 217 amino acids; 25337 Da
Subunit: Associates through its SH2 domain with ligand-activated receptors for stem cell factor (KIT) and
erythropoietin (EPOR). Also forms a stable complex with the Bcr-Abl oncoprotein. GRAP is associated with the Ras
guanine nucleotide exchange factor SOS1, primarily through its N-terminal SH3 domain. Interacts with
phosphorylated LAT upon TCR activation. Interacts with SHB

Explore the universe of human proteins at neXtProt for GRAP: NX_Q13588

Explore proteomics data for GRAP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13588

  • GRAP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GRAP Protein Expression
    REFSEQ proteins: NP_006604.1  
    ENSEMBL proteins: 
     ENSP00000284154   ENSP00000459833   ENSP00000378997   ENSP00000464328  
    Reactome Protein details: Q13588
    Human Recombinant Protein Products for GRAP: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for GRAP
    OriGene MassSpec for GRAP 
    OriGene Custom Protein Services for GRAP
    GenScript Custom Purified and Recombinant Proteins Services for GRAP
    Novus Biologicals GRAP Protein
    Novus Biologicals GRAP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS8647802
    GO:0005829cytosol TAS--

    GRAP for ontologies           About GeneDecksing



    GRAP Antibody Products: 
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    ThermoFisher Antibody for GRAP
    LSBio Antibodies in human, mouse, rat for GRAP 

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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SH2D: SH2 domain containing

    4 InterPro protein domains:
     IPR000108 p67phox
     IPR001452 SH3_domain
     IPR011511 SH3_2
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q13588

    ProtoNet protein and cluster: Q13588

    2 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature


    UniProtKB/Swiss-Prot: GRAP_HUMAN, Q13588
    Similarity: Belongs to the GRB2/sem-5/DRK family
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 2 SH3 domains


    GRAP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRAP_HUMAN, Q13588
    Function: Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity TAS8647802
    GO:0005515protein binding ----
         
    GRAP for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Grap):
     cellular  hematopoietic system  immune system 

    GRAP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Graptm1Gsf for GRAP

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GRAP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GRAP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRAP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GRAP 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GRAP
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate GRAP:
    hsa-miR-1182 hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidGRAP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GRAP
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of GRAP

    Clone
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    GenScript: all cDNA clones in your preferred vector: GRAP (NM_004810)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRAP
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                         Customized lentivirus expression plasmids for stable overexpression of GRAP 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRAP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GRAP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1PIP3 activates AKT signaling
    Signaling by SCF-KIT0.72
    2Signaling by GPCR
    Signal Transduction0.55
    3Signaling events mediated by Stem cell factor receptor (c-Kit)
    Kit Receptor Signaling Pathway0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for GRAP
        Kit Receptor Signaling Pathway

    2        Reactome Pathways for GRAP
        Signal Transduction
    Signaling by SCF-KIT



    GRAP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/21 Interacting proteins for GRAP (Q135882, 3 ENSP000002841544) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SHC1P293532, 3, ENSP000004013034MINT-8032732 I2D: score=3 STRING: ENSP00000401303
    BCRP112742, 3, ENSP000003035074MINT-8026518 I2D: score=1 STRING: ENSP00000303507
    ARHGAP32A7KAX93, ENSP000003105614STRING: ENSP00000310561 I2D: score=2 
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    LCKP062393, ENSP000003378254I2D: score=2 STRING: ENSP00000337825
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007265Ras protein signal transduction TAS8647802
    GO:0007267cell-cell signaling TAS8647802

    GRAP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GRAP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GRAP

    3 HMDB Compounds for GRAP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 Novoseek inferred chemical compound relationship for GRAP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 33.4 2 8647802 (1), 18339533 (1)

    Search CenterWatch for drugs/clinical trials and news about GRAP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GRAP gene: 
    NM_006613.3  

    Unigene Cluster for GRAP:

    GRB2-related adaptor protein
    Hs.567416  [show with all ESTs]
    Unigene Representative Sequence: NM_006613
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284154(uc002guy.3) ENST00000573099 ENST00000395635 ENST00000583020
    ENST00000571380
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GRAP
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate GRAP:
    hsa-miR-1182 hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidGRAP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRAP
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    GenScript: all cDNA clones in your preferred vector: GRAP (NM_004810)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRAP
    Sirion Biotech Customized lentivirus for stable overexpression of GRAP 
                         Customized lentivirus expression plasmids for stable overexpression of GRAP 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GRAP
    OriGene qSTAR qPCR primer pairs in human, mouse for GRAP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GRAP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRAP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRAP

    Additional mRNA sequence: 

    BC035856.1 BC063035.1 BT019981.1 CR541941.1 CR541966.1 U52518.1 

    12 DOTS entries:

    DT.400143  DT.423061  DT.100853419  DT.91857369  DT.100642363  DT.100831755  DT.92026222  DT.97784953 
    DT.97842428  DT.120954067  DT.120971530  DT.65284396 

    24/88 AceView cDNA sequences (see all 88):

    CR615744 BI821072 BX342636 BX401444 BQ059233 CR624975 CR541941 CR541966 
    BM457683 BC035856 NM_006613 BM985084 CR595033 BX457124 BQ064205 AA312640 
    AA766481 AI247233 AL040554 BQ062137 BF509642 BC063035 BX281266 CR600595 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GRAP    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:                                                                        
    SP2:                                      -                                 
    SP3:                                      -     -                           
    SP4:                                -     -     -                           


    ECgene alternative splicing isoforms for GRAP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GRAP expression in normal human tissues (normalized intensities)      GRAP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGGCTCTT
    GRAP Expression
    About this image


    GRAP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 21 entries
             PureStem endothelial progenitor 30-SM2-1
             Human Ovarian Microvascular Endothelial Cells (HOMEC)   
     
     Lymph (Hematopoietic System)    fully expand to see all 3 entries
             Human Lymphatic Endothelial Cells (HLEC)   
             LYMPH NODE   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             PureStem endothelial Progenitor 30-SM2-3
             reticulocytes   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Human Umbilical Vein Endothelial Cells (HUVEC) (BioTime)   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem progenitor RP1-MV2-16

    See GRAP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GRAP

    SOURCE GeneReport for Unigene cluster: Hs.567416
        SABiosciences Custom PCR Arrays for GRAP
    Primer
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRAP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRAP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRAP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GRAP gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grap1 , 5 GRB2-related adaptor protein1, 5 87.4(n)1
    92.17(a)1
      11 (37.96 cM)5
    715201  NM_027817.31  NP_082093.11 
     616532655 
    chicken
    (Gallus gallus)
    Aves GRAP1 GRB2-related adaptor protein 77.46(n)
    78.87(a)
      416523  XM_414827.3  XP_414827.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    67(a)
    1 → many
    GL343618.1(349579-368900)
    zebrafish
    (Danio rerio)
    Actinopterygii grapa1 GRB2-related adaptor protein a 63.22(n)
    61.03(a)
      553596  NM_001020573.1  NP_001018409.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sem-53 C. elegans sem-5 51(a)   X(7995288-7996908)   --


    ENSEMBL Gene Tree for GRAP (if available)
    TreeFam Gene Tree for GRAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GRAP gene
    GRAPL2  NCK12  NCK22  GRAP22  GRB22  
    18/22 SIMAP similar genes for GRAP using alignment to 4 protein entries:     GRAP_HUMAN (see all proteins) (see all similar genes):
    GRAPL    ITSN2    GRB2    GRAP2    ARHGEF7    ABL1
    SH3GL1    YES1    SH3GL2    FYN    HCK    CSK
    ABL2    BCR-ABL1 e19a2    NCKIPSD    BCR-ABL1    FGR    LCK

    GRAP for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for GRAP
    PGOHUM00000245192 PGOHUM00000262498


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/110 SNPs in GRAP are shown (see all 110)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1116361631,2
    C--18924644(+) CTGCCC/TGCCCC 1 -- ut311Minor allele frequency- T:0.50CSA 2
    rs1811710651,2
    --18924904(+) GGCCAC/GGGTTC 1 -- ut310--------
    rs1853354361,2
    --18924939(+) AAACCC/TGGGAG 1 -- ut310--------
    rs1881149631,2
    --18924986(+) AGGAGG/TTGGGC 1 -- ut310--------
    rs1471818921,2
    C--18924999(+) GGCCTC/TCACAG 1 -- ut310--------
    rs1137038561,2
    C,F--18925104(+) ACCTGA/GGCCAT 1 -- ut312Minor allele frequency- G:0.40CSA 5
    rs10574001,2
    C--18925125(-) GGCCGC/GTCTGC 1 -- ut31 ese32Minor allele frequency- G:0.00NA 4
    rs10573991,2
    C--18925148(-) AACGTG/AGGCTC 1 -- ut311Minor allele frequency- A:0.00NA 2
    rs1405078731,2
    --18925165(+) AAGGCC/TGTCCA 1 -- ut310--------
    rs1808460471,2
    --18925180(+) GCCCCA/GTGTGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for GRAP (18923986 - 18950950 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for GRAP (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv907789CNV Loss21882294
    nsv907825CNV Loss21882294
    nsv907795CNV Loss21882294
    nsv833391CNV Loss17160897
    dgv3082n71CNV Loss21882294
    dgv3083n71CNV Loss21882294
    dgv3086n71CNV Gain21882294
    nsv907786CNV Gain21882294
    dgv3080n71CNV Gain21882294
    dgv3085n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604330    OMIM disorders: --

    6 diseases for GRAP:    About MalaCards
    urethral stricture    phimosis    urethritis    hypospadias
    sjogren's syndrome    hepatocellular carcinoma


    GRAP for disorders           About GeneDecksing

    Genetic Association Database (GAD): GRAP
    Human Genome Epidemiology (HuGE) Navigator: GRAP (4 documents)

    Export disorders for GRAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GRAP gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with GRAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway. (PubMed id 8647802)1, 2, 3, 9 Feng G.-S.... Ni J. (1996)
    2. The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling. (PubMed id 8995379)1, 3, 9 Trub T....Shoelson S.E. (1997)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Polymorphisms of four bone mineral density candidate genes in Chinese populations and comparison with other populations of different ethnicity. (PubMed id 12491092)1, 4 Lei S.F....Deng H.W. (2003)
    5. Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins. (PubMed id 9484780)1, 2 Welsh M.... Shoelson S.E. (1998)
    6. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. (PubMed id 9489702)1, 2 Zhang W.... Samelson L.E. (1998)
    7. Quantitative mass spectrometry of diabetic kidney tub ules identifies GRAP as a novel regulator of TGF-beta signaling. (PubMed id 19836472)1, 9 Cummins T.D....Powell D.W. (2010)
    8. CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription. (PubMed id 18295596)1, 9 Schneider H. and Rudd C.E. (2008)
    9. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
    10. Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sjogren's syndrome. (PubMed id 15174222)1 Shiraiwa H....Sawada S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10750 HGNC: 4562 AceView: GRAP Ensembl:ENSG00000154016 euGenes: HUgn10750
    ECgene: GRAP H-InvDB: GRAP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GRAP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GRAP gene:
    Search GeneIP for patents involving GRAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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