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Aliases for GRAMD4 Gene

Aliases for GRAMD4 Gene

  • GRAM Domain Containing 4 2 3 5
  • Death-Inducing-Protein 2 3
  • Death-Inducing Protein 3 4
  • DIP 3 4
  • DA59H18.1 3
  • DJ439F8.1 3
  • KIAA0767 4

External Ids for GRAMD4 Gene

Previous GeneCards Identifiers for GRAMD4 Gene

  • GC22P045394
  • GC22P046971
  • GC22P029967

Summaries for GRAMD4 Gene

Entrez Gene Summary for GRAMD4 Gene

  • GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis (Stanelle et al., 2005 [PubMed 15565177]).[supplied by OMIM, Jan 2011]

GeneCards Summary for GRAMD4 Gene

GRAMD4 (GRAM Domain Containing 4) is a Protein Coding gene. Diseases associated with GRAMD4 include Lung Squamous Cell Carcinoma.

UniProtKB/Swiss-Prot for GRAMD4 Gene

  • Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRAMD4 Gene

Genomics for GRAMD4 Gene

Regulatory Elements for GRAMD4 Gene

Enhancers for GRAMD4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GRAMD4 on UCSC Golden Path with GeneCards custom track

Promoters for GRAMD4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GRAMD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for GRAMD4 Gene

46,576,012 bp from pter
46,682,758 bp from pter
106,747 bases
Plus strand

Genomic View for GRAMD4 Gene

Genes around GRAMD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRAMD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRAMD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRAMD4 Gene

Proteins for GRAMD4 Gene

  • Protein details for GRAMD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GRAM domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • A9IN51
    • A9IN57
    • Q68EN0
    • Q9UGE6
    • Q9Y4B9

    Protein attributes for GRAMD4 Gene

    578 amino acids
    Molecular mass:
    66408 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA34487.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GRAMD4 Gene


neXtProt entry for GRAMD4 Gene

Proteomics data for GRAMD4 Gene at MOPED

Post-translational modifications for GRAMD4 Gene

  • Ubiquitination at Lys 168
  • Modification sites at PhosphoSitePlus

Other Protein References for GRAMD4 Gene

No data available for DME Specific Peptides for GRAMD4 Gene

Domains & Families for GRAMD4 Gene

Gene Families for GRAMD4 Gene

Protein Domains for GRAMD4 Gene


Suggested Antigen Peptide Sequences for GRAMD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GRAM domain.
  • Contains 1 GRAM domain.
genes like me logo Genes that share domains with GRAMD4: view

Function for GRAMD4 Gene

Molecular function for GRAMD4 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53.
UniProtKB/Swiss-Prot Induction:
Up-regulated in the mitochondria by E2F1 after addition of 4-hydroxytamoxifen (at protein level).

Phenotypes for GRAMD4 Gene

GenomeRNAi human phenotypes for GRAMD4:
genes like me logo Genes that share phenotypes with GRAMD4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GRAMD4 Gene

Localization for GRAMD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRAMD4 Gene

Mitochondrion membrane; Multi-pass membrane protein. Note=Colocalizes with COX4I1. {ECO:0000269 PubMed:15565177}.

Subcellular locations from

Jensen Localization Image for GRAMD4 Gene COMPARTMENTS Subcellular localization image for GRAMD4 gene
Compartment Confidence
mitochondrion 4
plasma membrane 3
cytosol 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for GRAMD4 Gene

Pathways & Interactions for GRAMD4 Gene

SuperPathways for GRAMD4 Gene

No Data Available

Interacting Proteins for GRAMD4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000354313 for GRAMD4 Gene via STRING

Gene Ontology (GO) - Biological Process for GRAMD4 Gene


No data available for Pathways by source and SIGNOR curated interactions for GRAMD4 Gene

Drugs & Compounds for GRAMD4 Gene

No Compound Related Data Available

Transcripts for GRAMD4 Gene

Unigene Clusters for GRAMD4 Gene

GRAM domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRAMD4 Gene

No ASD Table

Relevant External Links for GRAMD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRAMD4 Gene

mRNA expression in normal human tissues for GRAMD4 Gene

mRNA differential expression in normal tissues according to GTEx for GRAMD4 Gene

This gene is overexpressed in Liver (x10.3).

Protein differential expression in normal tissues from HIPED for GRAMD4 Gene

This gene is overexpressed in Fetal Brain (13.5), Heart (12.0), and Liver (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for GRAMD4 Gene

SOURCE GeneReport for Unigene cluster for GRAMD4 Gene Hs.475150

mRNA Expression by UniProt/SwissProt for GRAMD4 Gene

Tissue specificity: Expressed in lung and in primary lung squamous cell carcinoma (LSCC).
genes like me logo Genes that share expression patterns with GRAMD4: view

Protein tissue co-expression partners for GRAMD4 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GRAMD4 Gene

Orthologs for GRAMD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRAMD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia GRAMD4 35
  • 87.78 (n)
  • 92.46 (a)
  • 74 (a)
(Mus musculus)
Mammalia Gramd4 35
  • 85.99 (n)
  • 94.46 (a)
Gramd4 16
Gramd4 36
  • 86 (a)
(Pan troglodytes)
Mammalia GRAMD4 35
  • 91.7 (n)
  • 89.32 (a)
  • 92 (a)
(Rattus norvegicus)
Mammalia Gramd4 35
  • 85.99 (n)
  • 94.81 (a)
(Bos Taurus)
Mammalia GRAMD4 36
  • 90 (a)
(Monodelphis domestica)
Mammalia GRAMD4 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia GRAMD4 36
  • 91 (a)
(Gallus gallus)
Aves GRAMD4 35
  • 77.29 (n)
  • 88.5 (a)
  • 82 (a)
(Anolis carolinensis)
Reptilia GRAMD4 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gramd4 35
  • 72.4 (n)
  • 80.53 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.31955 35
(Danio rerio)
Actinopterygii gramd4 36
  • 76 (a)
GRAMD4 (1 of 2) 36
  • 68 (a)
(Caenorhabditis elegans)
Secernentea Y77E11A.12 36
  • 18 (a)
Species with no ortholog for GRAMD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRAMD4 Gene

Gene Tree for GRAMD4 (if available)
Gene Tree for GRAMD4 (if available)

Paralogs for GRAMD4 Gene

genes like me logo Genes that share paralogs with GRAMD4: view

No data available for Paralogs for GRAMD4 Gene

Variants for GRAMD4 Gene

Sequence variations from dbSNP and Humsavar for GRAMD4 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs36211078 - 46,663,049(+) CCGGA(G/T)CCAGG reference, missense
rs3179 -- 46,679,565(+) CTAGA(C/T)GAATG intron-variant, utr-variant-3-prime
rs79160 -- 46,618,400(-) CTAGG(C/T)GCCGC intron-variant
rs2076707 -- 46,661,294(+) GTACA(C/T)GGTCG intron-variant
rs2076708 -- 46,661,300(+) GGTCG(C/T)GAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRAMD4 Gene

Variant ID Type Subtype PubMed ID
nsv829281 CNV Gain 20364138
nsv829293 CNV Gain 20364138
nsv834227 CNV Loss 17160897
dgv5016n71 CNV Loss 21882294
dgv5017n71 CNV Loss 21882294
dgv5018n71 CNV Loss 21882294
nsv915368 CNV Loss 21882294
dgv5019n71 CNV Loss 21882294
nsv915373 CNV Loss 21882294
esv2724440 CNV Deletion 23290073
esv2724441 CNV Deletion 23290073
dgv788e201 CNV Deletion 23290073
esv2724443 CNV Deletion 23290073
esv2724444 CNV Deletion 23290073
esv25117 CNV Loss 19812545
nsv820467 CNV Deletion 20802225
esv2724446 CNV Deletion 23290073
esv2724447 CNV Deletion 23290073
esv6748 CNV Gain 19470904
esv1441208 CNV Insertion 17803354
esv1407556 CNV Insertion 17803354
esv1433804 CNV Insertion 17803354
esv2724448 CNV Deletion 23290073
esv2724449 CNV Deletion 23290073
dgv5020n71 CNV Loss 21882294
esv2564691 CNV Insertion 19546169
nsv915376 CNV Loss 21882294

Variation tolerance for GRAMD4 Gene

Residual Variation Intolerance Score: 8.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.60% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GRAMD4 Gene

Disorders for GRAMD4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GRAMD4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GRAMD4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GRAMD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRAMD4 Gene

Publications for GRAMD4 Gene

  1. A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53. (PMID: 15565177) Stanelle J. … Puetzer B.M. (Cell Death Differ. 2005) 2 3 4 23 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. [Expression and clinicopathological significance of GRAMD4 in hepatocellular carcinoma]. (PMID: 23388340) Zhang J. … Liu Q. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2013) 3
  4. GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria. (PMID: 21127500) John K. … PA1tzer B.M. (Cell Death Differ. 2011) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for GRAMD4 Gene

Sources for GRAMD4 Gene