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Aliases for GRAMD3 Gene

Aliases for GRAMD3 Gene

  • GRAM Domain Containing 3 2 3
  • HCV NS3-Transactivated Protein 2 3 4
  • NS3TP2 3 4
  • Hepatitis C Virus Nonstructural Protein 3-Transactivating Protein 2 3
  • HCV NS3 Transactivated Protein 2 2

External Ids for GRAMD3 Gene

Previous GeneCards Identifiers for GRAMD3 Gene

  • GC05P125788
  • GC05P120886
  • GC05P125695

Summaries for GRAMD3 Gene

GeneCards Summary for GRAMD3 Gene

GRAMD3 (GRAM Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is GRAMD1A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRAMD3 Gene

Genomics for GRAMD3 Gene

Regulatory Elements for GRAMD3 Gene

Genomic Location for GRAMD3 Gene

126,360,096 bp from pter
126,496,494 bp from pter
136,399 bases
Plus strand

Genomic View for GRAMD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRAMD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRAMD3 Gene

Proteins for GRAMD3 Gene

  • Protein details for GRAMD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GRAM domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • B7Z1F2
    • B7Z3R1
    • B7Z6D8
    • B7Z8T2
    • D3DSZ3
    • Q9H753

    Protein attributes for GRAMD3 Gene

    432 amino acids
    Molecular mass:
    47869 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GRAMD3 Gene


neXtProt entry for GRAMD3 Gene

Proteomics data for GRAMD3 Gene at MOPED

Post-translational modifications for GRAMD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for GRAMD3 Gene

Domains & Families for GRAMD3 Gene

Gene Families for GRAMD3 Gene

Protein Domains for GRAMD3 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GRAM domain.
  • Contains 1 GRAM domain.
genes like me logo Genes that share domains with GRAMD3: view

Function for GRAMD3 Gene

Gene Ontology (GO) - Molecular Function for GRAMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GRAMD3: view
genes like me logo Genes that share phenotypes with GRAMD3: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRAMD3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GRAMD3 Gene

Localization for GRAMD3 Gene

Subcellular locations from

Jensen Localization Image for GRAMD3 Gene COMPARTMENTS Subcellular localization image for GRAMD3 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for GRAMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005881 cytoplasmic microtubule IDA 23264731
genes like me logo Genes that share ontologies with GRAMD3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GRAMD3 Gene

Pathways & Interactions for GRAMD3 Gene

SuperPathways for GRAMD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GRAMD3 Gene


No data available for Pathways by source and SIGNOR curated interactions for GRAMD3 Gene

Drugs & Compounds for GRAMD3 Gene

No Compound Related Data Available

Transcripts for GRAMD3 Gene

Unigene Clusters for GRAMD3 Gene

GRAM domain containing 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRAMD3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRAMD3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18
SP1: - - - -
SP2: - -
SP3: - -
SP4: - -
SP5: -
SP7: -

Relevant External Links for GRAMD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRAMD3 Gene

mRNA expression in normal human tissues for GRAMD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GRAMD3 Gene

This gene is overexpressed in Placenta (45.0) and Frontal cortex (18.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GRAMD3 Gene

SOURCE GeneReport for Unigene cluster for GRAMD3 Gene Hs.363558

genes like me logo Genes that share expression patterns with GRAMD3: view

Protein tissue co-expression partners for GRAMD3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GRAMD3 Gene

Orthologs for GRAMD3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GRAMD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GRAMD3 35
  • 89.12 (n)
  • 88.43 (a)
  • 83 (a)
(Canis familiaris)
Mammalia GRAMD3 35
  • 89.02 (n)
  • 89.33 (a)
  • 83 (a)
(Mus musculus)
Mammalia Gramd3 35
  • 85.73 (n)
  • 86.57 (a)
Gramd3 16
Gramd3 36
  • 83 (a)
(Pan troglodytes)
Mammalia GRAMD3 35
  • 99.77 (n)
  • 99.77 (a)
  • 85 (a)
(Rattus norvegicus)
Mammalia Gramd3 35
  • 84.98 (n)
  • 87.13 (a)
(Monodelphis domestica)
Mammalia GRAMD3 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia GRAMD3 36
  • 75 (a)
(Gallus gallus)
Aves GRAMD3 35
  • 64.47 (n)
  • 60.61 (a)
  • 59 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 61 (a)
-- 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gramd3 35
  • 57.48 (n)
  • 51.63 (a)
(Danio rerio)
Actinopterygii LOC100335008 35
  • 54.88 (n)
  • 47.53 (a)
  • 35 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6854 35
(Caenorhabditis elegans)
Secernentea ZC328.3 36
  • 12 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 7 (a)
YSP2 36
  • 6 (a)
Species with no ortholog for GRAMD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRAMD3 Gene

Gene Tree for GRAMD3 (if available)
Gene Tree for GRAMD3 (if available)

Paralogs for GRAMD3 Gene

Paralogs for GRAMD3 Gene

(3) SIMAP similar genes for GRAMD3 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with GRAMD3: view

Variants for GRAMD3 Gene

Structural Variations from Database of Genomic Variants (DGV) for GRAMD3 Gene

Variant ID Type Subtype PubMed ID
nsv830477 CNV Gain 17160897
nsv882831 CNV Gain 21882294
dgv6316n71 CNV Loss 21882294
nsv882834 CNV Loss 21882294
esv274394 CNV Insertion 20981092
nsv882835 CNV Gain 21882294
nsv4987 CNV Insertion 18451855
nsv4989 CNV Loss 18451855

Variation tolerance for GRAMD3 Gene

Residual Variation Intolerance Score: 51.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.70; 46.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRAMD3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for GRAMD3 Gene

Disorders for GRAMD3 Gene

Relevant External Links for GRAMD3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GRAMD3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRAMD3 Gene

Publications for GRAMD3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. (PMID: 23264731) Fong K.W. … Chen J. (J. Cell Sci. 2013) 67
  5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 67

Products for GRAMD3 Gene

Sources for GRAMD3 Gene

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