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Aliases for GRAMD3 Gene

Aliases for GRAMD3 Gene

  • GRAM Domain Containing 3 2 3 5
  • HCV NS3-Transactivated Protein 2 3 4
  • NS3TP2 3 4
  • Hepatitis C Virus Nonstructural Protein 3-Transactivating Protein 2 3
  • HCV NS3 Transactivated Protein 2 2
  • GRAM Domain-Containing Protein 3 3

External Ids for GRAMD3 Gene

Previous GeneCards Identifiers for GRAMD3 Gene

  • GC05P125788
  • GC05P120886
  • GC05P125695

Summaries for GRAMD3 Gene

GeneCards Summary for GRAMD3 Gene

GRAMD3 (GRAM Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is GRAMD2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRAMD3 Gene

Genomics for GRAMD3 Gene

Regulatory Elements for GRAMD3 Gene

Enhancers for GRAMD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around GRAMD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for GRAMD3 Gene

Chromosome:
5
Start:
126,360,096 bp from pter
End:
126,496,494 bp from pter
Size:
136,399 bases
Orientation:
Plus strand

Genomic View for GRAMD3 Gene

Genes around GRAMD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRAMD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRAMD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRAMD3 Gene

Proteins for GRAMD3 Gene

  • Protein details for GRAMD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HH9-GRAM3_HUMAN
    Recommended name:
    GRAM domain-containing protein 3
    Protein Accession:
    Q96HH9
    Secondary Accessions:
    • B7Z1F2
    • B7Z3R1
    • B7Z6D8
    • B7Z8T2
    • D3DSZ3
    • Q9H753

    Protein attributes for GRAMD3 Gene

    Size:
    432 amino acids
    Molecular mass:
    47869 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GRAMD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRAMD3 Gene

Post-translational modifications for GRAMD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GRAMD3 Gene

Domains & Families for GRAMD3 Gene

Gene Families for GRAMD3 Gene

Protein Domains for GRAMD3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96HH9

UniProtKB/Swiss-Prot:

GRAM3_HUMAN :
  • Contains 1 GRAM domain.
Domain:
  • Contains 1 GRAM domain.
genes like me logo Genes that share domains with GRAMD3: view

Function for GRAMD3 Gene

Gene Ontology (GO) - Molecular Function for GRAMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GRAMD3: view
genes like me logo Genes that share phenotypes with GRAMD3: view

Animal Model Products

CRISPR Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GRAMD3 Gene

Localization for GRAMD3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRAMD3 Gene COMPARTMENTS Subcellular localization image for GRAMD3 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
golgi apparatus 2
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GRAMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005881 cytoplasmic microtubule IDA 23264731
genes like me logo Genes that share ontologies with GRAMD3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GRAMD3 Gene

Pathways & Interactions for GRAMD3 Gene

SuperPathways for GRAMD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GRAMD3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GRAMD3 Gene

Drugs & Compounds for GRAMD3 Gene

No Compound Related Data Available

Transcripts for GRAMD3 Gene

Unigene Clusters for GRAMD3 Gene

GRAM domain containing 3:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRAMD3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18
SP1: - - - -
SP2: - -
SP3: - -
SP4: - -
SP5: -
SP6:
SP7: -

Relevant External Links for GRAMD3 Gene

GeneLoc Exon Structure for
GRAMD3
ECgene alternative splicing isoforms for
GRAMD3

Expression for GRAMD3 Gene

mRNA expression in normal human tissues for GRAMD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GRAMD3 Gene

This gene is overexpressed in Placenta (45.0) and Frontal cortex (18.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GRAMD3 Gene



Protein tissue co-expression partners for GRAMD3 Gene

NURSA nuclear receptor signaling pathways regulating expression of GRAMD3 Gene:

GRAMD3

SOURCE GeneReport for Unigene cluster for GRAMD3 Gene:

Hs.363558
genes like me logo Genes that share expression patterns with GRAMD3: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GRAMD3 Gene

Orthologs for GRAMD3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GRAMD3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GRAMD3 34
  • 89.12 (n)
  • 88.43 (a)
GRAMD3 35
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRAMD3 34
  • 89.02 (n)
  • 89.33 (a)
GRAMD3 35
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gramd3 34
  • 85.73 (n)
  • 86.57 (a)
Gramd3 16
Gramd3 35
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GRAMD3 34
  • 99.77 (n)
  • 99.77 (a)
GRAMD3 35
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gramd3 34
  • 84.98 (n)
  • 87.13 (a)
oppossum
(Monodelphis domestica)
Mammalia GRAMD3 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRAMD3 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRAMD3 34
  • 64.47 (n)
  • 60.61 (a)
GRAMD3 35
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 61 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gramd3 34
  • 57.48 (n)
  • 51.63 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100335008 34
  • 54.88 (n)
  • 47.53 (a)
GRAMD3 35
  • 35 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6854 34
worm
(Caenorhabditis elegans)
Secernentea ZC328.3 35
  • 12 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 7 (a)
ManyToMany
YSP2 35
  • 6 (a)
ManyToMany
Species where no ortholog for GRAMD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRAMD3 Gene

ENSEMBL:
Gene Tree for GRAMD3 (if available)
TreeFam:
Gene Tree for GRAMD3 (if available)

Paralogs for GRAMD3 Gene

Paralogs for GRAMD3 Gene

(3) SIMAP similar genes for GRAMD3 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with GRAMD3: view

Variants for GRAMD3 Gene

Sequence variations from dbSNP and Humsavar for GRAMD3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1422269 -- 126,405,250(-) TTTGT(C/T)TGGAG intron-variant
rs1422270 -- 126,402,581(-) GTGGA(C/T)CTGTC intron-variant
rs1422273 -- 126,374,621(-) TCTTA(A/T)GACTT intron-variant
rs1592871 -- 126,401,116(-) aaaaa(A/G)taaag intron-variant
rs4288110 -- 126,428,810(+) ttagc(A/G)aaacg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRAMD3 Gene

Variant ID Type Subtype PubMed ID
esv3310122 CNV mobile element insertion 20981092
esv3342460 CNV insertion 20981092
esv3390638 CNV insertion 20981092
esv3606677 CNV gain 21293372
esv3606678 CNV gain 21293372
esv3606679 CNV gain 21293372
esv3606680 CNV gain 21293372
nsv1016666 CNV loss 25217958
nsv4987 CNV insertion 18451855
nsv4989 CNV deletion 18451855
nsv830477 CNV gain 17160897

Variation tolerance for GRAMD3 Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.70; 46.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRAMD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRAMD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRAMD3 Gene

Disorders for GRAMD3 Gene

Relevant External Links for GRAMD3

Genetic Association Database (GAD)
GRAMD3
Human Genome Epidemiology (HuGE) Navigator
GRAMD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRAMD3

No disorders were found for GRAMD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRAMD3 Gene

Publications for GRAMD3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65

Products for GRAMD3 Gene

Sources for GRAMD3 Gene

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