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Aliases for GRAMD2B Gene

Aliases for GRAMD2B Gene

  • GRAM Domain Containing 2B 2 3
  • GRAM Domain Containing 3 2 3 5
  • GRAMD3 3 4 5
  • HCV NS3-Transactivated Protein 2 3 4
  • NS3TP2 3 4
  • Hepatitis C Virus Nonstructural Protein 3-Transactivating Protein 2 3
  • HCV NS3 Transactivated Protein 2 2
  • GRAM Domain-Containing Protein 3 3

External Ids for GRAMD2B Gene

Previous HGNC Symbols for GRAMD2B Gene

  • GRAMD3

Summaries for GRAMD2B Gene

GeneCards Summary for GRAMD2B Gene

GRAMD2B (GRAM Domain Containing 2B) is a Protein Coding gene. An important paralog of this gene is GRAMD2A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRAMD2B Gene

Genomics for GRAMD2B Gene

Regulatory Elements for GRAMD2B Gene

Enhancers for GRAMD2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G126518 1.3 Ensembl ENCODE dbSUPER 19.9 +159.4 159429 2.9 HDAC1 PKNOX1 TBL1XR1 NFIB CHAMP1 TCF12 ZNF766 CEBPB NCOA1 ZEB2 GRAMD2B ENSG00000250602 ENSG00000279118 GC05M126556
GH05G126512 1.6 Ensembl ENCODE dbSUPER 12.4 +155.0 154974 5.1 PKNOX1 CREB3L1 ARNT SIN3A FEZF1 ZNF766 FOS REST ZNF592 KAT8 ENSG00000250602 GRAMD2B ALDH7A1 ENSG00000279118 GC05M126556
GH05G126444 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +87.9 87934 8.0 TBP ZNF133 ZSCAN4 WRNIP1 SIN3A BRCA1 RFX5 SCRT2 ETV6 RELB ENSG00000250602 GRAMD2B ALDH7A1 LOC101927514
GH05G126382 1.5 Ensembl ENCODE dbSUPER 11.7 +24.8 24844 4.0 PKNOX1 FOXA2 ATF1 ARNT MLX SIN3A ARID4B FEZF1 BRCA1 ZNF2 GRAMD2B ENSG00000250602 LOC101927514
GH05G126437 1.3 FANTOM5 ENCODE dbSUPER 13.4 +78.4 78365 1.5 PKNOX1 WRNIP1 EED IKZF2 CREM ZNF680 MTA2 CBFB JUNB CEBPB GRAMD2B ENSG00000250602 LOC101927514
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GRAMD2B on UCSC Golden Path with GeneCards custom track

Genomic Location for GRAMD2B Gene

Chromosome:
5
Start:
126,360,096 bp from pter
End:
126,496,494 bp from pter
Size:
136,399 bases
Orientation:
Plus strand

Genomic View for GRAMD2B Gene

Genes around GRAMD2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRAMD2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRAMD2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRAMD2B Gene

Proteins for GRAMD2B Gene

  • Protein details for GRAMD2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HH9-GRAM3_HUMAN
    Recommended name:
    GRAM domain-containing protein 3
    Protein Accession:
    Q96HH9
    Secondary Accessions:
    • B7Z1F2
    • B7Z3R1
    • B7Z6D8
    • B7Z8T2
    • D3DSZ3
    • Q9H753

    Protein attributes for GRAMD2B Gene

    Size:
    432 amino acids
    Molecular mass:
    47869 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GRAMD2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRAMD2B Gene

Post-translational modifications for GRAMD2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GRAMD2B Gene

Domains & Families for GRAMD2B Gene

No data available for UniProtKB/Swiss-Prot for GRAMD2B Gene

Function for GRAMD2B Gene

Gene Ontology (GO) - Molecular Function for GRAMD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with GRAMD2B: view
genes like me logo Genes that share phenotypes with GRAMD2B: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GRAMD2B Gene

Localization for GRAMD2B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRAMD2B gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
golgi apparatus 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GRAMD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005881 cytoplasmic microtubule IDA 23264731
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GRAMD2B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GRAMD2B Gene

Pathways & Interactions for GRAMD2B Gene

SuperPathways for GRAMD2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for GRAMD2B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GRAMD2B Gene

Drugs & Compounds for GRAMD2B Gene

No Compound Related Data Available

Transcripts for GRAMD2B Gene

Unigene Clusters for GRAMD2B Gene

GRAM domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRAMD2B Gene

No ASD Table

Relevant External Links for GRAMD2B Gene

GeneLoc Exon Structure for
GRAMD2B
ECgene alternative splicing isoforms for
GRAMD2B

Expression for GRAMD2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of GRAMD2B Gene:

GRAMD2B

SOURCE GeneReport for Unigene cluster for GRAMD2B Gene:

Hs.363558

Evidence on tissue expression from TISSUES for GRAMD2B Gene

  • Nervous system(4.8)
  • Intestine(4.3)
genes like me logo Genes that share expression patterns with GRAMD2B: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRAMD2B Gene

Orthologs for GRAMD2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GRAMD2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRAMD3 34 35
  • 99.77 (n)
cow
(Bos Taurus)
Mammalia GRAMD3 34 35
  • 89.12 (n)
dog
(Canis familiaris)
Mammalia GRAMD3 34 35
  • 89.02 (n)
mouse
(Mus musculus)
Mammalia Gramd3 34 16 35
  • 85.73 (n)
rat
(Rattus norvegicus)
Mammalia Gramd3 34
  • 84.98 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GRAMD3 35
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRAMD3 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRAMD3 34 35
  • 64.47 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 61 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gramd3 34
  • 57.48 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100335008 34
  • 54.88 (n)
GRAMD3 35
  • 35 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6854 34
worm
(Caenorhabditis elegans)
Secernentea ZC328.3 35
  • 12 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 7 (a)
ManyToMany
YSP2 35
  • 6 (a)
ManyToMany
Species where no ortholog for GRAMD2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRAMD2B Gene

ENSEMBL:
Gene Tree for GRAMD2B (if available)
TreeFam:
Gene Tree for GRAMD2B (if available)

Paralogs for GRAMD2B Gene

Paralogs for GRAMD2B Gene

genes like me logo Genes that share paralogs with GRAMD2B: view

Variants for GRAMD2B Gene

Sequence variations from dbSNP and Humsavar for GRAMD2B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000011831 -- 126,481,977(+) AAAAA(A/G)AAAAA intron-variant
rs1000014996 -- 126,479,495(+) TCCTC(C/G)TTGTC intron-variant
rs1000072676 -- 126,361,131(+) CTGAC(C/T)ATAAT intron-variant
rs1000078594 -- 126,401,509(+) TGATT(C/T)TTTTT intron-variant
rs1000105749 -- 126,401,828(+) TTGAG(C/T)AGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRAMD2B Gene

Variant ID Type Subtype PubMed ID
esv3310122 CNV mobile element insertion 20981092
esv3342460 CNV insertion 20981092
esv3390638 CNV insertion 20981092
esv3606677 CNV gain 21293372
esv3606678 CNV gain 21293372
esv3606679 CNV gain 21293372
esv3606680 CNV gain 21293372
nsv1016666 CNV loss 25217958
nsv4987 CNV insertion 18451855
nsv4989 CNV deletion 18451855
nsv830477 CNV gain 17160897

Variation tolerance for GRAMD2B Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.70; 46.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRAMD2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRAMD2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRAMD2B Gene

Disorders for GRAMD2B Gene

Relevant External Links for GRAMD2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRAMD2B

No disorders were found for GRAMD2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRAMD2B Gene

Publications for GRAMD2B Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N. … Vidal M. (Cell 2015) 3 64

Products for GRAMD2B Gene

Sources for GRAMD2B Gene

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