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Aliases for GRAMD1C Gene

Aliases for GRAMD1C Gene

  • GRAM Domain Containing 1C 2 3 5

External Ids for GRAMD1C Gene

Previous GeneCards Identifiers for GRAMD1C Gene

  • GC03P115041
  • GC03P113547
  • GC03P110932

Summaries for GRAMD1C Gene

GeneCards Summary for GRAMD1C Gene

GRAMD1C (GRAM Domain Containing 1C) is a Protein Coding gene. An important paralog of this gene is GRAMD1B.

Additional gene information for GRAMD1C Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRAMD1C Gene

Genomics for GRAMD1C Gene

Regulatory Elements for GRAMD1C Gene

Enhancers for GRAMD1C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H113829 1.2 Ensembl ENCODE 36.4 +3.2 3226 3 HDGF PKNOX1 FOXA2 ARID4B ATF7 FOS RUNX3 JUNB KAT8 NFIL3 GRAMD1C QTRT2 CCDC191 GC03M113852
GH03H113838 0.9 ENCODE 31.3 +10.8 10790 1 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF143 ZNF207 RUNX3 MXD4 REST GRAMD1C QTRT2 CCDC191 GC03M113852
GH03H113782 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -44.3 -44342 2 PKNOX1 JUN CEBPG BATF POLR2A FOS NFE2 ATF7 RUNX3 CREM ATP6V1A GRAMD1C USF3 NAA50 ENSG00000242659
GH03H113769 0.9 Ensembl dbSUPER 11.7 -58.4 -58382 0 JUN ZFP64 ZC3H11A ZNF781 ZNF518A ZNF697 JUND ATF3 FOS FOSL2 GRAMD1C ENSG00000259976 ATP6V1A ENSG00000242659
GH03H113788 0.9 ENCODE dbSUPER 11.6 -39.4 -39374 0 EBF1 ATF2 RELA IKZF1 EED ATF7 RUNX3 IKZF2 SPI1 GRAMD1C ENSG00000242659
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GRAMD1C on UCSC Golden Path with GeneCards custom track

Genomic Location for GRAMD1C Gene

Chromosome:
3
Start:
113,828,182 bp from pter
End:
113,947,174 bp from pter
Size:
118,993 bases
Orientation:
Plus strand

Genomic View for GRAMD1C Gene

Genes around GRAMD1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRAMD1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRAMD1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRAMD1C Gene

Proteins for GRAMD1C Gene

  • Protein details for GRAMD1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYS0-GRM1C_HUMAN
    Recommended name:
    GRAM domain-containing protein 1C
    Protein Accession:
    Q8IYS0
    Secondary Accessions:
    • A8K9Y1
    • A8KA99
    • Q6AW94
    • Q6UWN1
    • Q8N6S0
    • Q9UF46

    Protein attributes for GRAMD1C Gene

    Size:
    662 amino acids
    Molecular mass:
    76035 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH28972.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GRAMD1C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRAMD1C Gene

Post-translational modifications for GRAMD1C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GRAMD1C Gene

Domains & Families for GRAMD1C Gene

Gene Families for GRAMD1C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GRAMD1C Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GRAMD1C: view

No data available for UniProtKB/Swiss-Prot for GRAMD1C Gene

Function for GRAMD1C Gene

Phenotypes From GWAS Catalog for GRAMD1C Gene

Gene Ontology (GO) - Molecular Function for GRAMD1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GRAMD1C: view
genes like me logo Genes that share phenotypes with GRAMD1C: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GRAMD1C

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GRAMD1C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GRAMD1C Gene

Localization for GRAMD1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRAMD1C Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRAMD1C gene
Compartment Confidence
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GRAMD1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GRAMD1C: view

Pathways & Interactions for GRAMD1C Gene

SuperPathways for GRAMD1C Gene

No Data Available

Gene Ontology (GO) - Biological Process for GRAMD1C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GRAMD1C Gene

Drugs & Compounds for GRAMD1C Gene

No Compound Related Data Available

Transcripts for GRAMD1C Gene

Unigene Clusters for GRAMD1C Gene

GRAM domain containing 1C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GRAMD1C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GRAMD1C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^
SP1: - - - - - -
SP2: - - - -
SP3: -
SP4:
SP5: - -
SP6: - - -
SP7:

ExUns: 19 ^ 20a · 20b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for GRAMD1C Gene

GeneLoc Exon Structure for
GRAMD1C
ECgene alternative splicing isoforms for
GRAMD1C

Expression for GRAMD1C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRAMD1C Gene

Protein differential expression in normal tissues from HIPED for GRAMD1C Gene

This gene is overexpressed in Testis (26.1), Fetal heart (18.5), and Liver (17.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRAMD1C Gene



Protein tissue co-expression partners for GRAMD1C Gene

NURSA nuclear receptor signaling pathways regulating expression of GRAMD1C Gene:

GRAMD1C

SOURCE GeneReport for Unigene cluster for GRAMD1C Gene:

Hs.24583

Evidence on tissue expression from TISSUES for GRAMD1C Gene

  • Liver(4.3)
genes like me logo Genes that share expression patterns with GRAMD1C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRAMD1C Gene

Orthologs for GRAMD1C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GRAMD1C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRAMD1C 33 34
  • 99.35 (n)
dog
(Canis familiaris)
Mammalia GRAMD1C 34
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gramd1c 33
  • 83.43 (n)
cow
(Bos Taurus)
Mammalia GRAMD1C 34
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gramd1c 34
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRAMD1C 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRAMD1C 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRAMD1C 33 34
  • 70.52 (n)
lizard
(Anolis carolinensis)
Reptilia GRAMD1C 34
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13605 33
zebrafish
(Danio rerio)
Actinopterygii si:ch73-93k15.2 33
  • 55.25 (n)
GRAMD1C 34
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30284 34
  • 20 (a)
ManyToMany
CG34394 34
  • 15 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ZC328.3 34
  • 24 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 10 (a)
ManyToMany
YSP2 34
  • 9 (a)
ManyToMany
Species where no ortholog for GRAMD1C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GRAMD1C Gene

ENSEMBL:
Gene Tree for GRAMD1C (if available)
TreeFam:
Gene Tree for GRAMD1C (if available)

Paralogs for GRAMD1C Gene

Paralogs for GRAMD1C Gene

(2) SIMAP similar genes for GRAMD1C Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with GRAMD1C: view

Variants for GRAMD1C Gene

Sequence variations from dbSNP and Humsavar for GRAMD1C Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000034899 -- 113,882,098(+) GTCTT(A/G)TTGCA intron-variant
rs1000039589 -- 113,905,290(+) GCACA(A/G)CAATA intron-variant
rs1000040390 -- 113,843,379(+) GCCCA(C/T)ATGCT intron-variant
rs1000061758 -- 113,826,940(+) CAAAA(A/T)CTTTT upstream-variant-2KB
rs1000107412 -- 113,837,327(+) TCTGA(A/G)ACAGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GRAMD1C Gene

Variant ID Type Subtype PubMed ID
dgv4841n100 CNV loss 25217958
dgv617n27 CNV loss 19166990
dgv8506n54 CNV loss 21841781
dgv8507n54 CNV loss 21841781
dgv8508n54 CNV loss 21841781
esv2674471 CNV deletion 23128226
esv3568963 CNV loss 25503493
esv3597444 CNV loss 21293372
esv3597445 CNV loss 21293372
esv3893765 CNV loss 25118596
nsv1013506 CNV gain 25217958
nsv1013746 CNV gain 25217958
nsv1114418 CNV deletion 24896259
nsv1117020 CNV deletion 24896259
nsv1127987 CNV deletion 24896259
nsv460822 CNV loss 19166990
nsv473469 CNV novel sequence insertion 20440878
nsv516703 CNV loss 19592680
nsv591306 CNV loss 21841781
nsv829678 CNV loss 17160897
nsv965200 CNV duplication 23825009

Variation tolerance for GRAMD1C Gene

Residual Variation Intolerance Score: 66.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRAMD1C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRAMD1C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRAMD1C Gene

Disorders for GRAMD1C Gene

Relevant External Links for GRAMD1C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRAMD1C

No disorders were found for GRAMD1C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRAMD1C Gene

Publications for GRAMD1C Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N … Vidal M (Cell 2015) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for GRAMD1C Gene

Sources for GRAMD1C Gene

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