GRAMD1C Gene
protein-coding GIFtS: 43
GCID: GC03P113547
|
|
GRAM domain containing 1C
| |
Aliases
for GRAMD1C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| GRAM Domain Containing 1C1 2 | | DKFZp434C03281 | | GRAM Domain-Containing Protein 1C2 |
Export aliases for GRAMD1C gene to outside databasesPrevious GC identifers: GC03P115041 GC03P110932 |
Summaries
for GRAMD1C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for GRAMD1C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GRAMD1C gene promoter:
NF-AT NF-AT4 NF-AT2 FOXO1a NF-AT3 ARP-1 FOXO1 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for GRAMD1C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRAMD1C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q13.31 Ensembl cytogenetic band: 3q13.31 HGNC cytogenetic band: 3q13.31GRAMD1C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P113547: view genomic region
(about GC identifiers)
Start:
|
113,547,029 bp from pter |
End:
|
113,666,021 bp from pter |
Size:
|
118,993 bases |
Orientation:
|
plus strand |
|
Proteins
for GRAMD1C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GRM1C_HUMAN, Q8IYS0 (See
protein sequence)Recommended Name: GRAM domain-containing protein 1C Size: 662 amino acids; 76035 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=AAH28972.1; Type=Erroneous initiation;
Secondary accessions: A8K9Y1 Q6AW94 Q6UWN1 Q8N6S0 Q9UF46Alternative splicing: 2 isoforms: Q8IYS0-1 Q8IYS0-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for GRAMD1C: NX_Q8IYS0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IYS0
GRAMD1C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001165576.1 NP_060047.3
ENSEMBL proteins: ENSP00000350881 ENSP00000417936 ENSP00000418990 ENSP00000418501 ENSP00000419132 ENSP00000418302 ENSP00000408135 ENSP00000419571 ENSP00000399844
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
GRAMD1C for ontologies About GeneDecksing
GRAMD1C Antibody Products:
Assay Products for GRAMD1C: |
Protein
Domains /
Families
for GRAMD1C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GRAMD1C for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IYS0ProtoNet protein and cluster: Q8IYS0 UniProtKB/Swiss-Prot: GRM1C_HUMAN, Q8IYS0Similarity: Contains 1 GRAM domain |
Function
for GRAMD1C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRAMD1C (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRAMD1C (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): GRAMD1C (NM_017577) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GRAMD1C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRAMD1C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRAMD1C |
|
Pathways & Interactions
for GRAMD1C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GRAMD1C
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for GRAMD1C (Q8IYS02, 3 ENSP000003508814) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for GRAMD1C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GRAMD1C
Search CenterWatch for drugs/clinical trials and news about GRAMD1C / GRM1C
|
Transcripts
for GRAMD1C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GRAMD1C gene (2 alternative transcripts): NM_001172105.1 NM_017577.4 Unigene Cluster for GRAMD1C: GRAM domain containing 1C Hs.24583 [show with all ESTs]Unigene Representative Sequence: BC03504016 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000479212 ENST00000358160(uc011bil.2 uc011bim.1 uc003eaq.4 uc003ear.3 uc003eat.3)
ENST00000498183 ENST00000486457 ENST00000472384 ENST00000463760 ENST00000484714
ENST00000467895 ENST00000472026 ENST00000462838 ENST00000440446(uc003eas.3)
ENST00000488680 ENST00000471031 ENST00000466898 ENST00000491038 ENST00000452134
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRAMD1C (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRAMD1C (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): GRAMD1C (NM_017577) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GRAMD1C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRAMD1C |
Additional cDNA sequence: AK093181.1 AK097783.1 AK292846.1 AK292964.1 AK293884.1 AK304142.1 AY358725.1 BC028972.2 BC035040.1 BX537661.1 9 DOTS entries: DT.410899 DT.100652246 DT.40251409 DT.91673345 DT.100649554 DT.120862555 DT.99938578 DT.205300 DT.100691907 24/103 AceView cDNA sequences (see all 103): CB155997 AA885321 BF431474 AA625897 AI377259 AK097783 AI024185 AL133661 BX537661 AW117419 AA921762 AA343661 BE673027 BC035040 AA825698 AI657189 AW473785 AA904678 BX342100 AK093181 BF508926 NM_017577 BF434787 BM698756
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GRAMD1C (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19 | ^ | 20a | · | 20b |
|---|
|
| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for GRAMD1C
|
Expression
for GRAMD1C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GRAMD1C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See GRAMD1C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GRAMD1C
SOURCE GeneReport for Unigene cluster: Hs.24583
SABiosciences Custom PCR Arrays for GRAMD1C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GRAMD1C
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRAMD1C |
Orthologs
for GRAMD1C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for GRAMD1C gene from 8/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
GRAMD1C1 |
GRAM domain containing 1C |
70.96(n)
66.28(a) |
|
418354 XM_416574.3 XP_416574.3 |
lizard
(Anolis carolinensis) |
Reptilia |
GRAMD1C6 |
-- |
66(a) |
1 ↔ 1 |
3(176451890-176456875) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.136052 |
Xenopus laevis transcribed sequence with weak similarity more |
74.07(n) |
|
BU915557.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wu:fe11c031 |
wu:fe11c03 |
55.05(n)
48.81(a) |
|
563054 XM_683292.5 XP_688384.4 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG302846CG343946 |
-- |
17(a)13(a) |
many ↔ manymany ↔ many |
2R(17538325-17539504) 2L(3358640-3373372) |
worm
(Caenorhabditis elegans) |
Secernentea |
ZC328.36 |
Protein ZC328.3, isoform b |
21(a) |
possible ortholog |
I(6409062-6416885) |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
YFL042C1 |
hypothetical protein |
41.11(n)
27.19(a) |
|
850501 NP_116611.1 |
rice
(Oryza sativa) |
Liliopsida |
-- |
expressed protein |
16(a) |
1 → many |
7(18320789-18323700) |
ENSEMBL Gene Tree for GRAMD1C (if available)
TreeFam Gene Tree for GRAMD1C (if available) |
Paralogs
for GRAMD1C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GRAMD1C gene
- GRAMD22 GRAMD32 GRAMD1B2 GRAMD1A2
2 SIMAP similar genes for GRAMD1C using alignment to 9 protein entries: GRM1C_HUMAN (see all proteins):GRAMD1A GRAMD1B
GRAMD1C for paralogs About GeneDecksing
|
Genomic Variants
for GRAMD1C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GRAMD1C (113547029 - 113666021 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for GRAMD1C
4 CNVs: 50906 4351 53252 50905
1 Indel: 40554 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GRAMD1C |
|
Disorders
/ Diseases
for GRAMD1C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for GRAMD1C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GRAMD1C gene integrated from 9 sources:
(articles sorted by number of sources associating them with GRAMD1C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for GRAMD1C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GRAMD1C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GRAMD1C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GRAMD1C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GRAMD1C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GRAMD1C gene:
Search GeneIP for patents involving GRAMD1C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GRAMD1C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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 |
 | | | GRAMD1C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRAMD1C |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRAMD1C |
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