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Aliases for GRAMD1A Gene

Aliases for GRAMD1A Gene

  • GRAM Domain Containing 1A 2 3
  • KIAA1533 2 3 4
  • GRAM Domain-Containing Protein 1A 3

External Ids for GRAMD1A Gene

Previous Symbols for GRAMD1A Gene

  • KIAA1533

Summaries for GRAMD1A Gene

GeneCards Summary for GRAMD1A Gene

GRAMD1A (GRAM Domain Containing 1A) is a Protein Coding gene. An important paralog of this gene is GRAMD3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRAMD1A Gene

Genomics for GRAMD1A Gene

Genomic Location for GRAMD1A Gene

Start:
34,994,784 bp from pter
End:
35,026,471 bp from pter
Size:
31,688 bases
Orientation:
Plus strand

Genomic View for GRAMD1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRAMD1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRAMD1A Gene

Regulatory Elements for GRAMD1A Gene

Proteins for GRAMD1A Gene

  • Protein details for GRAMD1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CP6-GRM1A_HUMAN
    Recommended name:
    GRAM domain-containing protein 1A
    Protein Accession:
    Q96CP6
    Secondary Accessions:
    • A6NKY7
    • Q8NC77
    • Q9P1Z5

    Protein attributes for GRAMD1A Gene

    Size:
    724 amino acids
    Molecular mass:
    80680 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GRAMD1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRAMD1A Gene

Proteomics data for GRAMD1A Gene at MOPED

Post-translational modifications for GRAMD1A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys87, Lys513, and Lys655

Other Protein References for GRAMD1A Gene

No data available for DME Specific Peptides for GRAMD1A Gene

Domains for GRAMD1A Gene

Protein Domains for GRAMD1A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GRAMD1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96CP6

UniProtKB/Swiss-Prot:

GRM1A_HUMAN
Domain:
  • Contains 1 GRAM domain.:
    • Q96CP6
genes like me logo Genes that share domains with GRAMD1A: view

No data available for Gene Families for GRAMD1A Gene

Function for GRAMD1A Gene

Gene Ontology (GO) - Molecular Function for GRAMD1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GRAMD1A: view

miRNA for GRAMD1A Gene

miRTarBase miRNAs that target GRAMD1A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GRAMD1A Gene

Localization for GRAMD1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRAMD1A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRAMD1A Gene COMPARTMENTS Subcellular localization image for GRAMD1A gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GRAMD1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GRAMD1A: view

Pathways for GRAMD1A Gene

SuperPathways for GRAMD1A Gene

No Data Available

Interacting Proteins for GRAMD1A Gene

Gene Ontology (GO) - Biological Process for GRAMD1A Gene

None

No data available for Pathways by source for GRAMD1A Gene

Transcripts for GRAMD1A Gene

Unigene Clusters for GRAMD1A Gene

GRAM domain containing 1A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRAMD1A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^
SP1: - - - - - - -
SP2: - - - -
SP3:
SP4: -
SP5:
SP6: - - - - -
SP7:
SP8: -
SP9:
SP10:

ExUns: 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for GRAMD1A Gene

GeneLoc Exon Structure for
GRAMD1A
ECgene alternative splicing isoforms for
GRAMD1A

Expression for GRAMD1A Gene

mRNA expression in normal human tissues for GRAMD1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRAMD1A Gene

This gene is overexpressed in Whole Blood (9.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GRAMD1A Gene

SOURCE GeneReport for Unigene cluster for GRAMD1A Gene Hs.515351

genes like me logo Genes that share expressions with GRAMD1A: view

No data available for mRNA Expression by UniProt/SwissProt for GRAMD1A Gene

Orthologs for GRAMD1A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GRAMD1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRAMD1A 35
  • 99.49 (n)
  • 99.45 (a)
GRAMD1A 36
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GRAMD1A 35
  • 91.58 (n)
  • 96.35 (a)
GRAMD1A 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRAMD1A 35
  • 91.68 (n)
  • 97.09 (a)
GRAMD1A 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gramd1a 35
  • 87.56 (n)
  • 94.01 (a)
Gramd1a 16
Gramd1a 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRAMD1A 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gramd1a 35
  • 86.91 (n)
  • 93.53 (a)
lizard
(Anolis carolinensis)
Reptilia GRAMD1A 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gramd1a 35
  • 62.11 (n)
  • 57.27 (a)
zebrafish
(Danio rerio)
Actinopterygii gramd1a 35
  • 59.48 (n)
  • 54.99 (a)
gramd1a 36
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30284 36
  • 20 (a)
ManyToMany
CG34394 36
  • 18 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ZC328.3 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 10 (a)
ManyToMany
YSP2 36
  • 10 (a)
ManyToMany
Species with no ortholog for GRAMD1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRAMD1A Gene

ENSEMBL:
Gene Tree for GRAMD1A (if available)
TreeFam:
Gene Tree for GRAMD1A (if available)

Paralogs for GRAMD1A Gene

Paralogs for GRAMD1A Gene

Selected SIMAP similar genes for GRAMD1A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GRAMD1A: view

Variants for GRAMD1A Gene

Sequence variations from dbSNP and Humsavar for GRAMD1A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1051184 -- 35,026,330(+) GGCCT(C/T)TGGCA utr-variant-3-prime
rs1060892 -- 35,014,687(+) AAAAT(A/G)GGGTT intron-variant
rs1063591 -- 35,026,287(+) GGACC(A/C)CGGAA utr-variant-3-prime
rs1870065 -- 35,026,580(-) GTTTC(A/G)GTGAC downstream-variant-500B
rs2290642 -- 35,010,147(+) CTCTC(C/T)GAGAA synonymous-codon, reference, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GRAMD1A Gene

Variant ID Type Subtype PubMed ID
nsv911610 CNV Loss 21882294
dgv3848n71 CNV Loss 21882294
nsv911613 CNV Loss 21882294

Relevant External Links for GRAMD1A Gene

HapMap Linkage Disequilibrium report
GRAMD1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRAMD1A Gene

Disorders for GRAMD1A Gene

No disorders were found for GRAMD1A Gene.

No data available for UniProtKB/Swiss-Prot for GRAMD1A Gene

Publications for GRAMD1A Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for GRAMD1A Gene

Sources for GRAMD1A Gene

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