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Aliases for GRAMD1A Gene

Aliases for GRAMD1A Gene

  • GRAM Domain Containing 1A 2 3
  • KIAA1533 2 3 4
  • GRAM Domain-Containing Protein 1A 3

External Ids for GRAMD1A Gene

Previous HGNC Symbols for GRAMD1A Gene

  • KIAA1533

Previous GeneCards Identifiers for GRAMD1A Gene

  • GC19P040174
  • GC19P035486
  • GC19P031999
  • GC19P035533
  • GC19P035679
  • GC19P035789
  • GC19P035952

Summaries for GRAMD1A Gene

GeneCards Summary for GRAMD1A Gene

GRAMD1A (GRAM Domain Containing 1A) is a Protein Coding gene. An important paralog of this gene is GRAMD3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRAMD1A Gene

Genomics for GRAMD1A Gene

Regulatory Elements for GRAMD1A Gene

Genomic Location for GRAMD1A Gene

34,994,784 bp from pter
35,026,471 bp from pter
31,688 bases
Plus strand

Genomic View for GRAMD1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRAMD1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRAMD1A Gene

Proteins for GRAMD1A Gene

  • Protein details for GRAMD1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GRAM domain-containing protein 1A
    Protein Accession:
    Secondary Accessions:
    • A6NKY7
    • Q8NC77
    • Q9P1Z5

    Protein attributes for GRAMD1A Gene

    724 amino acids
    Molecular mass:
    80680 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GRAMD1A Gene


neXtProt entry for GRAMD1A Gene

Proteomics data for GRAMD1A Gene at MOPED

Post-translational modifications for GRAMD1A Gene

  • Ubiquitination at Lys87, Lys513, and Lys655
  • Modification sites at PhosphoSitePlus

Other Protein References for GRAMD1A Gene

No data available for DME Specific Peptides for GRAMD1A Gene

Domains for GRAMD1A Gene

Protein Domains for GRAMD1A Gene


Suggested Antigen Peptide Sequences for GRAMD1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GRAM domain.
  • Contains 1 GRAM domain.
genes like me logo Genes that share domains with GRAMD1A: view

No data available for Gene Families for GRAMD1A Gene

Function for GRAMD1A Gene

Gene Ontology (GO) - Molecular Function for GRAMD1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GRAMD1A: view

Animal Model Products

CRISPR Products

miRNA for GRAMD1A Gene

miRTarBase miRNAs that target GRAMD1A

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRAMD1A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for GRAMD1A Gene

Localization for GRAMD1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRAMD1A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GRAMD1A Gene COMPARTMENTS Subcellular localization image for GRAMD1A gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GRAMD1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GRAMD1A: view

Pathways for GRAMD1A Gene

SuperPathways for GRAMD1A Gene

No Data Available

Interacting Proteins for GRAMD1A Gene

Gene Ontology (GO) - Biological Process for GRAMD1A Gene


No data available for Pathways by source for GRAMD1A Gene

Transcripts for GRAMD1A Gene

Unigene Clusters for GRAMD1A Gene

GRAM domain containing 1A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRAMD1A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRAMD1A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^
SP1: - - - - - - -
SP2: - - - -
SP4: -
SP6: - - - - -
SP8: -

ExUns: 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23
SP1: -
SP2: -
SP3: -

Relevant External Links for GRAMD1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRAMD1A Gene

mRNA expression in normal human tissues for GRAMD1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRAMD1A Gene

This gene is overexpressed in Whole Blood (9.0).

Protein differential expression in normal tissues for GRAMD1A Gene

This gene is overexpressed in Urine (51.8) and Fetal Brain (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GRAMD1A Gene

SOURCE GeneReport for Unigene cluster for GRAMD1A Gene Hs.515351

genes like me logo Genes that share expressions with GRAMD1A: view

Expression partners for GRAMD1A Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GRAMD1A Gene

Orthologs for GRAMD1A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GRAMD1A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GRAMD1A 35
  • 91.58 (n)
  • 96.35 (a)
  • 85 (a)
(Canis familiaris)
Mammalia GRAMD1A 35
  • 91.68 (n)
  • 97.09 (a)
  • 86 (a)
(Mus musculus)
Mammalia Gramd1a 35
  • 87.56 (n)
  • 94.01 (a)
Gramd1a 16
Gramd1a 36
  • 93 (a)
(Pan troglodytes)
Mammalia GRAMD1A 35
  • 99.49 (n)
  • 99.45 (a)
  • 88 (a)
(Rattus norvegicus)
Mammalia Gramd1a 35
  • 86.91 (n)
  • 93.53 (a)
(Monodelphis domestica)
Mammalia GRAMD1A 36
  • 76 (a)
(Anolis carolinensis)
Reptilia GRAMD1A 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gramd1a 35
  • 62.11 (n)
  • 57.27 (a)
(Danio rerio)
Actinopterygii gramd1a 35
  • 59.48 (n)
  • 54.99 (a)
gramd1a 36
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30284 36
  • 20 (a)
CG34394 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea ZC328.3 36
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 10 (a)
YSP2 36
  • 10 (a)
Species with no ortholog for GRAMD1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRAMD1A Gene

Gene Tree for GRAMD1A (if available)
Gene Tree for GRAMD1A (if available)

Paralogs for GRAMD1A Gene

Paralogs for GRAMD1A Gene

(3) SIMAP similar genes for GRAMD1A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GRAMD1A: view

Variants for GRAMD1A Gene

Sequence variations from dbSNP and Humsavar for GRAMD1A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1051184 -- 35,026,330(+) GGCCT(C/T)TGGCA utr-variant-3-prime
rs1060892 -- 35,014,687(+) AAAAT(A/G)GGGTT intron-variant
rs2290642 -- 35,010,147(+) CTCTC(C/T)GAGAA synonymous-codon, reference, utr-variant-5-prime
rs2290643 -- 35,022,277(-) TCCTT(A/G)GGTGA intron-variant
rs2290644 -- 35,022,238(-) CCCCC(C/G)GGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRAMD1A Gene

Variant ID Type Subtype PubMed ID
nsv911610 CNV Loss 21882294
dgv3848n71 CNV Loss 21882294
nsv911613 CNV Loss 21882294

Relevant External Links for GRAMD1A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRAMD1A Gene

Disorders for GRAMD1A Gene

No disorders were found for GRAMD1A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for GRAMD1A Gene

Publications for GRAMD1A Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for GRAMD1A Gene

Sources for GRAMD1A Gene

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