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Aliases for GPX8 Gene

Aliases for GPX8 Gene

  • Glutathione Peroxidase 8 (Putative) 2 3 5
  • EC 4 61
  • GSHPx-8 3 4
  • GPx-8 3 4
  • Probable Glutathione Peroxidase 8 3
  • EC 1.11.1 61
  • EPLA847 3
  • UNQ847 3

External Ids for GPX8 Gene

Previous GeneCards Identifiers for GPX8 Gene

  • GC05P054493
  • GC05P051429
  • GC05P054455

Summaries for GPX8 Gene

GeneCards Summary for GPX8 Gene

GPX8 (Glutathione Peroxidase 8 (Putative)) is a Protein Coding gene. Among its related pathways are Glutathione metabolism and Cellular Senescence. GO annotations related to this gene include oxidoreductase activity and peroxidase activity. An important paralog of this gene is GPX7.

Gene Wiki entry for GPX8 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPX8 Gene

Genomics for GPX8 Gene

Regulatory Elements for GPX8 Gene

Enhancers for GPX8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F055711 1.1 ENCODE 23.7 +552.3 552307 2.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ZNF143 GPX8 DDX4 ENSG00000264281 RPL26P19 IL31RA DHX29 SKIV2L2 SLC38A9 RNA5SP183 GC05P055648
GH05F055463 0.9 FANTOM5 19.4 +304.0 303986 0.3 ZFP64 ZNF493 ZNF155 ZNF121 ZNF23 ZNF138 ZNF354C KLF7 ZNF202 ZNF362 DHX29 SLC38A9 RNF138P1 GPX8 ENSG00000264281 LOC100419851 ENSG00000279883 GC05M055421
GH05F054900 1.3 FANTOM5 Ensembl ENCODE 12 -258.0 -257950 2.7 PKNOX1 BHLHE40 ZBED1 CBFB MAX JUNB TBX21 GABPA RELA SMARCA4 GPX8 LOC100130990 ENSG00000249016 MIR449A MIR449B CDC20B MIR449C GZMK ENSG00000240535 SNX18
GH05F056010 1.4 Ensembl ENCODE 10.5 +852.2 852248 3.0 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 DHX29 RPL26P19 ENSG00000264281 GPX8 ENSG00000271828 IL6ST ENSG00000238326 LOC105378976
GH05F056112 1.2 Ensembl ENCODE 10.6 +952.7 952723 0.9 TBP INSM2 FEZF1 RAD21 BRCA1 ZNF2 ZEB1 RFX5 ZNF121 ZNF366 ENSG00000271828 DHX29 SLC38A9 GPX8 ENSG00000238326 LOC101928419 LOC105378976
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPX8 on UCSC Golden Path with GeneCards custom track

Promoters for GPX8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001869127 483 2000 TBP INSM2 SIN3A FEZF1 ZNF2 RAD21 RFX5 ZNF366 RCOR1 ZNF263

Genomic Location for GPX8 Gene

55,160,118 bp from pter
55,167,301 bp from pter
7,184 bases
Plus strand

Genomic View for GPX8 Gene

Genes around GPX8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPX8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPX8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPX8 Gene

Proteins for GPX8 Gene

  • Protein details for GPX8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable glutathione peroxidase 8
    Protein Accession:

    Protein attributes for GPX8 Gene

    209 amino acids
    Molecular mass:
    23881 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GPX8 Gene

neXtProt entry for GPX8 Gene

Selected DME Specific Peptides for GPX8 Gene


Post-translational modifications for GPX8 Gene

  • Ubiquitination at Lys 128
  • Modification sites at PhosphoSitePlus

Other Protein References for GPX8 Gene

Domains & Families for GPX8 Gene

Suggested Antigen Peptide Sequences for GPX8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glutathione peroxidase family.
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX8: view

No data available for Gene Families for GPX8 Gene

Function for GPX8 Gene

Molecular function for GPX8 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.

Enzyme Numbers (IUBMB) for GPX8 Gene

Gene Ontology (GO) - Molecular Function for GPX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity EXP,IEA 21215271
GO:0004602 glutathione peroxidase activity IEA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with GPX8: view

Phenotypes for GPX8 Gene

GenomeRNAi human phenotypes for GPX8:
genes like me logo Genes that share phenotypes with GPX8: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPX8

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPX8 Gene

Localization for GPX8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX8 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPX8 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
cytoskeleton 2
cytosol 2
mitochondrion 1
peroxisome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GPX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPX8: view

Pathways & Interactions for GPX8 Gene

genes like me logo Genes that share pathways with GPX8: view

Pathways by source for GPX8 Gene

Gene Ontology (GO) - Biological Process for GPX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species TAS --
GO:0006979 response to oxidative stress IEA --
GO:0055114 oxidation-reduction process IEA --
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with GPX8: view

No data available for SIGNOR curated interactions for GPX8 Gene

Drugs & Compounds for GPX8 Gene

(3) Drugs for GPX8 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target 0
Water Approved Pharma 0
Hydrogen peroxide Pharma 55

(1) Additional Compounds for GPX8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Oxidized glutathione
  • (2S)-2-azaniumyl-4-{[(1R)-2-{[(2R)-2-[(4S)-4-azaniumyl-4-carboxylatobutanamido]-2-[(carboxylatomethyl)carbamoyl]ethyl]disulfanyl}-1-[(carboxylatomethyl)carbamoyl]ethyl]carbamoyl}butanoate
  • Glutathione disulfide
  • GSSG
  • L(-)-Glutathione(oxidized)
  • Oxiglutatione
genes like me logo Genes that share compounds with GPX8: view

Transcripts for GPX8 Gene

mRNA/cDNA for GPX8 Gene

(5) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPX8 Gene

Glutathione peroxidase 8 (putative):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPX8 Gene

No ASD Table

Relevant External Links for GPX8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPX8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPX8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GPX8 Gene

This gene is overexpressed in Bone (49.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GPX8 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPX8 Gene:


SOURCE GeneReport for Unigene cluster for GPX8 Gene:

genes like me logo Genes that share expression patterns with GPX8: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GPX8 Gene

Orthologs for GPX8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GPX8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPX8 34 35
  • 99.2 (n)
(Bos Taurus)
Mammalia GPX8 34 35
  • 91.55 (n)
(Canis familiaris)
Mammalia GPX8 34 35
  • 91.39 (n)
-- 35
  • 86 (a)
(Rattus norvegicus)
Mammalia Gpx8 34
  • 83.73 (n)
(Mus musculus)
Mammalia Gpx8 34 16 35
  • 82.62 (n)
(Monodelphis domestica)
Mammalia mdo-mir-449c 35
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia GPX8 35
  • 75 (a)
(Gallus gallus)
Aves GPX8 34 35
  • 75.28 (n)
(Anolis carolinensis)
Reptilia GPX8 35
  • 69 (a)
(Danio rerio)
Actinopterygii gpx8 34 35
  • 64.75 (n)
(Caenorhabditis elegans)
Secernentea gpx-3 35
  • 22 (a)
gpx-5 35
  • 22 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D03905g 34
  • 44.09 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPX2 35
  • 39 (a)
HYR1 35
  • 36 (a)
GPX1 35
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
Species where no ortholog for GPX8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GPX8 Gene

Gene Tree for GPX8 (if available)
Gene Tree for GPX8 (if available)

Paralogs for GPX8 Gene

Paralogs for GPX8 Gene

(2) SIMAP similar genes for GPX8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GPX8: view

Variants for GPX8 Gene

Sequence variations from dbSNP and Humsavar for GPX8 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10054014 -- 55,165,756(+) TCCTA(C/T)CTCTC intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10057543 -- 55,163,786(+) TACAG(A/G)CTGAG intron-variant
rs10059517 -- 55,164,338(+) AGTAG(C/T)GCGTT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1047689 -- 55,164,231(+) ATTGC(A/G)TTTCT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10940459 -- 55,162,708(+) GCCCA(A/C)GCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPX8 Gene

Variant ID Type Subtype PubMed ID
nsv830302 CNV gain 17160897

Variation tolerance for GPX8 Gene

Residual Variation Intolerance Score: 56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPX8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPX8 Gene

Disorders for GPX8 Gene

Relevant External Links for GPX8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPX8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPX8 Gene

Publications for GPX8 Gene

  1. GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum. (PMID: 24566470) Ramming T. … Appenzeller-Herzog C. (Free Radic. Biol. Med. 2014) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Glutathione peroxidase 8 is transcriptionally regulated by HIFI+ and modulates growth factor signaling in HeLa cells. (PMID: 25557012) Bosello-Travain V. … Maiorino M. (Free Radic. Biol. Med. 2015) 3 64

Products for GPX8 Gene

Sources for GPX8 Gene

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