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GPX8 Gene(Protein Coding)

Glutathione Peroxidase 8 (Putative)

GCID:
GC05P055160
GIFtS:
52
Genes Participants
UDN Logo

Aliases for GPX8 Gene

Aliases for GPX8 Gene

  • Glutathione Peroxidase 8 (Putative) 2 3 5
  • EC 1.11.1.9 4 63
  • GSHPx-8 3 4
  • GPx-8 3 4
  • EC 1.11.1 63
  • EPLA847 3
  • UNQ847 3

External Ids for GPX8 Gene

Previous GeneCards Identifiers for GPX8 Gene

  • GC05P054493
  • GC05P051429
  • GC05P054455

Summaries for GPX8 Gene

GeneCards Summary for GPX8 Gene

GPX8 (Glutathione Peroxidase 8 (Putative)) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Linoleic acid metabolism. GO annotations related to this gene include oxidoreductase activity and peroxidase activity. An important paralog of this gene is GPX5.

Gene Wiki entry for GPX8 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPX8 Gene

Genomics for GPX8 Gene

Products:

  1. Regulatory Element

Regulatory Elements for GPX8 Gene

Enhancers for GPX8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPX8 on UCSC Golden Path with GeneCards custom track

Promoters for GPX8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPX8 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the GPX8 gene promoter:

Genomic Location for GPX8 Gene

Chromosome:
5
Start:
55,160,118 bp from pter
End:
55,167,301 bp from pter
Size:
7,184 bases
Orientation:
Plus strand

Genomic View for GPX8 Gene

Genes around GPX8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPX8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPX8 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GPX8 Gene

Proteins for GPX8 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GPX8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TED1-GPX8_HUMAN
    Recommended name:
    Probable glutathione peroxidase 8
    Protein Accession:
    Q8TED1

    Protein attributes for GPX8 Gene

    Size:
    209 amino acids
    Molecular mass:
    23881 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GPX8 Gene

neXtProt entry for GPX8 Gene

Proteomics data for GPX8 Gene at MOPED

Protein Expression for GPX8 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for GPX8 Gene

Q8TED1:

Post-translational modifications for GPX8 Gene

  • Ubiquitination at Lys 128
  • Modification sites at PhosphoSitePlus

Other Protein References for GPX8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GPX8 Gene

Protein Domains for GPX8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GPX8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TED1

UniProtKB/Swiss-Prot:

GPX8_HUMAN :
  • Belongs to the glutathione peroxidase family.
Family:
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX8: view

No data available for Gene Families for GPX8 Gene

Function for GPX8 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for GPX8 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.

Enzyme Numbers (IUBMB) for GPX8 Gene

Phenotypes for GPX8 Gene

GenomeRNAi human phenotypes for GPX8:
genes like me logo Genes that share phenotypes with GPX8: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPX8

miRNA for GPX8 Gene

miRTarBase miRNAs that target GPX8

Inhibitory RNA Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPX8 Gene

Localization for GPX8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX8 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPX8 Gene COMPARTMENTS Subcellular localization image for GPX8 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
cytoskeleton 2
cytosol 2
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for GPX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with GPX8: view

Pathways & Interactions for GPX8 Gene

genes like me logo Genes that share pathways with GPX8: view

Pathways by source for GPX8 Gene

1 BioSystems pathway for GPX8 Gene

Interacting Proteins for GPX8 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000423822%0d%0a9606.ENSP00000293761%0d%0a9606.ENSP00000359998%0d%0a9606.ENSP00000248935%0d%0a9606.ENSP00000284562%0d%0a9606.ENSP00000381340%0d%0a
Selected Interacting proteins: ENSP00000423822 for GPX8 Gene via STRING

Gene Ontology (GO) - Biological Process for GPX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IEA --
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with GPX8: view

No data available for SIGNOR curated interactions for GPX8 Gene

Drugs & Compounds for GPX8 Gene

Products:

  1. Drug

(2) Drugs for GPX8 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target 0
Hydrogen peroxide Pharma 47

(2) Additional Compounds for GPX8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Oxidized glutathione
  • (2S)-2-azaniumyl-4-{[(1R)-2-{[(2R)-2-[(4S)-4-azaniumyl-4-carboxylatobutanamido]-2-[(carboxylatomethyl)carbamoyl]ethyl]disulfanyl}-1-[(carboxylatomethyl)carbamoyl]ethyl]carbamoyl}butanoate
  • Glutathione disulfide
  • GSSG
  • L(-)-Glutathione(oxidized)
  • Oxiglutatione
 27025-41-8
Water
  • Dihydrogen oxide
  • Steam
 7732-18-5
genes like me logo Genes that share compounds with GPX8: view

Transcripts for GPX8 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for GPX8 Gene

(6) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPX8 Gene

Glutathione peroxidase 8 (putative):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPX8 Gene

No ASD Table

Relevant External Links for GPX8 Gene

GeneLoc Exon Structure for
GPX8
ECgene alternative splicing isoforms for
GPX8

Expression for GPX8 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for GPX8 Gene

mRNA expression in normal human tissues for GPX8 Gene
mRNA expression by BioGPS for GPX8 GenemRNA expression by GTEx for GPX8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GPX8 Gene

This gene is overexpressed in Bone (49.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPX8 Gene



SOURCE GeneReport for Unigene cluster for GPX8 Gene Hs.289044

genes like me logo Genes that share expression patterns with GPX8: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GPX8 Gene

Orthologs for GPX8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GPX8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia GPX8 35
  • 91.55 (n)
  • 89 (a)
GPX8 36
  • 89 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia GPX8 35
  • 91.39 (n)
  • 88.52 (a)
-- 36
  • 86 (a)
 OneToMany
GPX8 36
  • 89 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Gpx8 35
  • 82.62 (n)
  • 82.3 (a)
Gpx8 16
Gpx8 36
  • 82 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia GPX8 35
  • 99.2 (n)
  • 99.04 (a)
GPX8 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Gpx8 35
  • 83.73 (n)
  • 83.25 (a)
oppossum
(Monodelphis domestica)
 Mammalia mdo-mir-449c 36
  • 79 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia GPX8 36
  • 75 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves GPX8 35
  • 75.28 (n)
  • 73.68 (a)
GPX8 36
  • 73 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia GPX8 36
  • 69 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii gpx8 35
  • 64.75 (n)
  • 63.64 (a)
gpx8 36
  • 62 (a)
 OneToOne
worm
(Caenorhabditis elegans)
 Secernentea gpx-3 36
  • 22 (a)
 ManyToMany
gpx-5 36
  • 22 (a)
 ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0D03905g 35
  • 44.09 (n)
  • 36.13 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes GPX1 36
  • 33 (a)
 ManyToMany
GPX2 36
  • 39 (a)
 ManyToMany
HYR1 36
  • 36 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 42 (a)
 OneToMany
Species with no ortholog for GPX8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GPX8 Gene

ENSEMBL:
Gene Tree for GPX8 (if available)
TreeFam:
Gene Tree for GPX8 (if available)

Paralogs for GPX8 Gene

Paralogs for GPX8 Gene

(2) SIMAP similar genes for GPX8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GPX8: view

Variants for GPX8 Gene

Sequence variations from dbSNP and Humsavar for GPX8 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_060456 -

Structural Variations from Database of Genomic Variants (DGV) for GPX8 Gene

Variant ID Type Subtype PubMed ID
nsv830302 CNV Gain 17160897

Variation tolerance for GPX8 Gene

Residual Variation Intolerance Score: 56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.94% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPX8 Gene

Disorders for GPX8 Gene

Relevant External Links for GPX8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPX8

No disorders were found for GPX8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPX8 Gene

Publications for GPX8 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Glutathione peroxidase 8 is transcriptionally regulated by HIFI+ and modulates growth factor signaling in HeLa cells. (PMID: 25557012) Bosello-Travain V. … Maiorino M. (Free Radic. Biol. Med. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum. (PMID: 24566470) Ramming T. … Appenzeller-Herzog C. (Free Radic. Biol. Med. 2014) 3
  5. Quantitative proteomics identifies the membrane-associated peroxidase GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease. (PMID: 23929719) Morikawa K. … Moradpour D. (Hepatology 2013) 3

Products for GPX8 Gene

Sources for GPX8 Gene

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