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Aliases for GPX7 Gene

Aliases for GPX7 Gene

  • Glutathione Peroxidase 7 2 3 5
  • EC 1.11.1.9 4 58
  • GSHPx-7 3 4
  • CL683 3 4
  • GPx-7 3 4
  • GPX6 3 4
  • Non-Selenocysteine Containing Phospholipid Hydroperoxide Glutathione Peroxidase 3
  • Glutathione Peroxidase 6 3
  • EC 1.11.1 58
  • NPGPx 3

External Ids for GPX7 Gene

Previous GeneCards Identifiers for GPX7 Gene

  • GC00U990130
  • GC01U900343
  • GC01P052438
  • GC01P052780
  • GC01P052840
  • GC01P053068
  • GC01P051188

Summaries for GPX7 Gene

GeneCards Summary for GPX7 Gene

GPX7 (Glutathione Peroxidase 7) is a Protein Coding gene. Diseases associated with GPX7 include Childhood Kidney Cell Carcinoma. Among its related pathways are Insulin secretion and Cellular Senescence (REACTOME). GO annotations related to this gene include oxidoreductase activity and peroxidase activity. An important paralog of this gene is GPX8.

UniProtKB/Swiss-Prot for GPX7 Gene

  • It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.

Gene Wiki entry for GPX7 Gene

Additional gene information for GPX7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPX7 Gene

Genomics for GPX7 Gene

Regulatory Elements for GPX7 Gene

Enhancers for GPX7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H052601 0.8 ENCODE 70.3 +0.9 929 4 SOX13 PKNOX1 BACH1 ZNF644 ZNF316 POLR2A SCRT2 ATF7 PRDM10 NR2F6 GPX7 CC2D1B FAM159A ZCCHC11 GC01P052619
GH01H052631 1.9 FANTOM5 Ensembl ENCODE dbSUPER 26.9 +33.0 32982 8 HDGF PKNOX1 SIN3A YBX1 ZNF766 ZNF207 ATF7 RUNX3 CAVIN1 JUNB ZCCHC11 GPX7 MAGOH PRPF38A ENSG00000230953 ENSG00000272100 CC2D1B ECHDC2 FAM159A GC01P052637
GH01H052532 1 Ensembl ENCODE 23.2 -69.7 -69731 1 SMARCE1 L3MBTL2 GTF2E2 ZMYM3 PTTG1 ZBTB40 ZKSCAN1 ZNF592 GATA2 ADNP GPX7 ZCCHC11 CC2D1B PRPF38A GC01P052532 GC01P052542
GH01H052550 1.4 FANTOM5 ENCODE 11.7 -49.5 -49473 5 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 CBX5 ZNF143 ZNF207 ENSG00000228838 ZCCHC11 PRPF38A CC2D1B LOC100652967 TXNDC12-AS1 ENSG00000226938 SLC25A6P3 GAPDHP51 MAGOH
GH01H052422 1 Ensembl ENCODE 15.9 -178.1 -178114 2 LEF1 ARNT ETV1 ZNF175 MAX CEBPG FOSL1 GATA3 ZNF316 POLR2A ZCCHC11 CC2D1B GPX7 PRPF38A GC01M052527
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPX7 on UCSC Golden Path with GeneCards custom track

Promoters for GPX7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000006409 229 801 ZNF687 POLR2A NR2F1 BACH1 EZH2

Genomic Location for GPX7 Gene

Chromosome:
1
Start:
52,602,371 bp from pter
End:
52,609,051 bp from pter
Size:
6,681 bases
Orientation:
Plus strand

Genomic View for GPX7 Gene

Genes around GPX7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPX7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPX7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPX7 Gene

Proteins for GPX7 Gene

  • Protein details for GPX7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SL4-GPX7_HUMAN
    Recommended name:
    Glutathione peroxidase 7
    Protein Accession:
    Q96SL4
    Secondary Accessions:
    • O95337
    • Q5T501

    Protein attributes for GPX7 Gene

    Size:
    187 amino acids
    Molecular mass:
    20996 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC72961.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GPX7 Gene

neXtProt entry for GPX7 Gene

Selected DME Specific Peptides for GPX7 Gene

Q96SL4:
  • LAFPCNQF
  • FPCNQFGQQEP
  • VSLEKYRG
  • FPCNQFG

Post-translational modifications for GPX7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPX7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GPX7 Gene

Gene Families for GPX7 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for GPX7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96SL4

UniProtKB/Swiss-Prot:

GPX7_HUMAN :
  • Belongs to the glutathione peroxidase family.
Family:
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX7: view

Function for GPX7 Gene

Molecular function for GPX7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
UniProtKB/Swiss-Prot Function:
It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.

Enzyme Numbers (IUBMB) for GPX7 Gene

Gene Ontology (GO) - Molecular Function for GPX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004096 catalase activity IDA 22157330
GO:0004601 peroxidase activity EXP 21215271
GO:0004602 glutathione peroxidase activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with GPX7: view
genes like me logo Genes that share phenotypes with GPX7: view

Animal Models for GPX7 Gene

MGI Knock Outs for GPX7:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPX7

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPX7
  • Applied Biological Materials Clones for GPX7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPX7 Gene

Localization for GPX7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPX7 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
nucleus 3
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GPX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005783 endoplasmic reticulum IDA 21215271
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with GPX7: view

Pathways & Interactions for GPX7 Gene

genes like me logo Genes that share pathways with GPX7: view

Pathways by source for GPX7 Gene

1 GeneGo (Thomson Reuters) pathway for GPX7 Gene

Gene Ontology (GO) - Biological Process for GPX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IEA --
GO:0034599 cellular response to oxidative stress TAS --
GO:0055114 oxidation-reduction process IEA --
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with GPX7: view

No data available for SIGNOR curated interactions for GPX7 Gene

Drugs & Compounds for GPX7 Gene

(5) Drugs for GPX7 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target, cofactor 0
Hydrogen peroxide Approved, Vet_approved Pharma 68
Selenium Approved, Vet_approved Pharma 185
Water Approved Pharma 0
Oxidized glutathione Experimental Pharma 0

(5) Additional Compounds for GPX7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15(S)-HETE
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoic acid
54845-95-3
15(S)-HPETE
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • 15-Hydroperoxyeicosatetraenoate
  • 15-Hydroperoxyeicosatetraenoic acid
  • 15-Hydroperoxyicosatetraenoate
70981-96-3
5(S)-Hydroperoxyeicosatetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
71774-08-8
5-HETE
  • 5(S)-HETE
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5(S)-Hydroxyeicosatetraenoate
  • 5(S)-Hydroxyeicosatetraenoic acid
70608-72-9
5-Hpete
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-HPETE
74581-83-2
genes like me logo Genes that share compounds with GPX7: view

Transcripts for GPX7 Gene

mRNA/cDNA for GPX7 Gene

Unigene Clusters for GPX7 Gene

Glutathione peroxidase 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPX7
  • Applied Biological Materials Clones for GPX7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GPX7 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2: -
SP3:

Relevant External Links for GPX7 Gene

GeneLoc Exon Structure for
GPX7
ECgene alternative splicing isoforms for
GPX7

Expression for GPX7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPX7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GPX7 Gene

This gene is overexpressed in Fetal testis (14.8), Fetal gut (7.3), Fetal heart (6.5), and Fetal Liver (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GPX7 Gene



NURSA nuclear receptor signaling pathways regulating expression of GPX7 Gene:

GPX7

SOURCE GeneReport for Unigene cluster for GPX7 Gene:

Hs.43728

mRNA Expression by UniProt/SwissProt for GPX7 Gene:

Q96SL4-GPX7_HUMAN
Tissue specificity: Expressed in esophageal epithelial cells; expression is up-regulated after exposure to acidic bile acids.

Evidence on tissue expression from TISSUES for GPX7 Gene

  • Blood(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with GPX7: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPX7 Gene

Orthologs for GPX7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GPX7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPX7 33 34
  • 99.11 (n)
cow
(Bos Taurus)
Mammalia GPX7 34 33
  • 91.82 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpx7 33
  • 88.89 (n)
mouse
(Mus musculus)
Mammalia Gpx7 16 34 33
  • 88.49 (n)
dog
(Canis familiaris)
Mammalia GPX7 34 33
  • 85.39 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPX7 34
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPX7 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPX7 33 34
  • 70.83 (n)
lizard
(Anolis carolinensis)
Reptilia GPX7 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpx7 33
  • 70.44 (n)
zebrafish
(Danio rerio)
Actinopterygii gpx7 34 33
  • 69.06 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gpx-4 34
  • 25 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL039C 33
  • 54.87 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HYR1 33 34
  • 49.46 (n)
GPX2 34 36
  • 36 (a)
ManyToMany
GPX1 34
  • 33 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F06732g 33
  • 47.71 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09534 33
  • 53.97 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gpx1 33
  • 45.7 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
OneToMany
Species where no ortholog for GPX7 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPX7 Gene

ENSEMBL:
Gene Tree for GPX7 (if available)
TreeFam:
Gene Tree for GPX7 (if available)

Paralogs for GPX7 Gene

Paralogs for GPX7 Gene

(4) SIMAP similar genes for GPX7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPX7: view

Variants for GPX7 Gene

Sequence variations from dbSNP and Humsavar for GPX7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000019423 -- 52,603,197(+) GGCAG(C/G)TCAGG intron-variant
rs1000477403 -- 52,609,050(+) CTCCT(C/T)ATTTT utr-variant-3-prime
rs1000517957 -- 52,609,296(+) TAGGC(C/T)GGGCG downstream-variant-500B
rs1000621703 -- 52,601,897(+) CAGCC(A/G)TCACT upstream-variant-2KB
rs1000993913 -- 52,601,465(+) AGACA(C/T)TGTGA upstream-variant-2KB

Variation tolerance for GPX7 Gene

Residual Variation Intolerance Score: 73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPX7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPX7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPX7 Gene

Disorders for GPX7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPX7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
childhood kidney cell carcinoma
  • pediatric renal cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search GPX7 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

GPX7_HUMAN
  • Barrett esophagus (BE) [MIM:614266]: A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. {ECO:0000269 PubMed:22157330}. Note=The disease is caused by mutations affecting the gene represented in this entry. The pathologic mechanisms leading to Barrett esophagus involve GPX7 dysfunction that results in higher levels of hydrogen peroxide and ROS-induced oxidative stress and DNA damage in esophageal cells.

Relevant External Links for GPX7

Genetic Association Database (GAD)
GPX7
Human Genome Epidemiology (HuGE) Navigator
GPX7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPX7
genes like me logo Genes that share disorders with GPX7: view

No data available for Genatlas for GPX7 Gene

Publications for GPX7 Gene

  1. Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells. (PMID: 22157330) Peng D … El-Rifai W (Gut 2012) 3 4 60
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  3. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 45 60
  4. Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. (PMID: 20200426) Moyer AM … Weinshilboum RM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 45 60
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60

Products for GPX7 Gene

  • Addgene plasmids for GPX7

Sources for GPX7 Gene

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