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Aliases for GPX7 Gene

Aliases for GPX7 Gene

  • Glutathione Peroxidase 7 2 3 5
  • EC 1.11.1.9 4 63
  • GSHPx-7 3 4
  • CL683 3 4
  • GPx-7 3 4
  • GPX6 3 4
  • Non-Selenocysteine Containing Phospholipid Hydroperoxide Glutathione Peroxidase 3
  • Glutathione Peroxidase 6 3
  • EC 1.11.1 63
  • NPGPx 3

External Ids for GPX7 Gene

Previous GeneCards Identifiers for GPX7 Gene

  • GC00U990130
  • GC01U900343
  • GC01P052438
  • GC01P052780
  • GC01P052840
  • GC01P053068
  • GC01P051188

Summaries for GPX7 Gene

GeneCards Summary for GPX7 Gene

GPX7 (Glutathione Peroxidase 7) is a Protein Coding gene. Diseases associated with GPX7 include Childhood Kidney Cell Carcinoma. Among its related pathways are Glutathione metabolism and Cellular Senescence. GO annotations related to this gene include oxidoreductase activity and peroxidase activity. An important paralog of this gene is GPX5.

UniProtKB/Swiss-Prot for GPX7 Gene

  • It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.

Gene Wiki entry for GPX7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPX7 Gene

Genomics for GPX7 Gene

Regulatory Elements for GPX7 Gene

Enhancers for GPX7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPX7 on UCSC Golden Path with GeneCards custom track

Promoters for GPX7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPX7 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPX7 Gene

Chromosome:
1
Start:
52,602,371 bp from pter
End:
52,609,051 bp from pter
Size:
6,681 bases
Orientation:
Plus strand

Genomic View for GPX7 Gene

Genes around GPX7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPX7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPX7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPX7 Gene

Proteins for GPX7 Gene

  • Protein details for GPX7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SL4-GPX7_HUMAN
    Recommended name:
    Glutathione peroxidase 7
    Protein Accession:
    Q96SL4
    Secondary Accessions:
    • O95337
    • Q5T501

    Protein attributes for GPX7 Gene

    Size:
    187 amino acids
    Molecular mass:
    20996 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC72961.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GPX7 Gene

neXtProt entry for GPX7 Gene

Proteomics data for GPX7 Gene at MOPED

Selected DME Specific Peptides for GPX7 Gene

Post-translational modifications for GPX7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPX7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GPX7 Gene

Protein Domains for GPX7 Gene

Suggested Antigen Peptide Sequences for GPX7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96SL4

UniProtKB/Swiss-Prot:

GPX7_HUMAN :
  • Belongs to the glutathione peroxidase family.
Family:
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX7: view

No data available for Gene Families for GPX7 Gene

Function for GPX7 Gene

Molecular function for GPX7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
UniProtKB/Swiss-Prot Function:
It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.

Enzyme Numbers (IUBMB) for GPX7 Gene

Gene Ontology (GO) - Molecular Function for GPX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004096 catalase activity IDA 22157330
genes like me logo Genes that share ontologies with GPX7: view
genes like me logo Genes that share phenotypes with GPX7: view

Animal Models for GPX7 Gene

MGI Knock Outs for GPX7:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPX7

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPX7 Gene

Localization for GPX7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPX7 Gene COMPARTMENTS Subcellular localization image for GPX7 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
nucleus 3
chloroplast 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for GPX7 Gene

Pathways & Interactions for GPX7 Gene

genes like me logo Genes that share pathways with GPX7: view

Pathways by source for GPX7 Gene

1 GeneGo (Thomson Reuters) pathway for GPX7 Gene

Gene Ontology (GO) - Biological Process for GPX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IEA --
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with GPX7: view

No data available for SIGNOR curated interactions for GPX7 Gene

Drugs & Compounds for GPX7 Gene

(3) Drugs for GPX7 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target, cofactor 0
Hydrogen peroxide Pharma 47
Selenium Pharma 168

(7) Additional Compounds for GPX7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15(S)-HETE
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoic acid
54845-95-3
15(S)-HPETE
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • 15-Hydroperoxyeicosatetraenoate
  • 15-Hydroperoxyeicosatetraenoic acid
  • 15-Hydroperoxyicosatetraenoate
70981-96-3
5(S)-Hydroperoxyeicosatetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
71774-08-8
5-HETE
  • 5(S)-HETE
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5(S)-Hydroxyeicosatetraenoate
  • 5(S)-Hydroxyeicosatetraenoic acid
70608-72-9
5-Hpete
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-HPETE
74581-83-2
genes like me logo Genes that share compounds with GPX7: view

Transcripts for GPX7 Gene

mRNA/cDNA for GPX7 Gene

Unigene Clusters for GPX7 Gene

Glutathione peroxidase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPX7 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2: -
SP3:

Relevant External Links for GPX7 Gene

GeneLoc Exon Structure for
GPX7
ECgene alternative splicing isoforms for
GPX7

Expression for GPX7 Gene

mRNA expression in normal human tissues for GPX7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GPX7 Gene

This gene is overexpressed in Fetal testis (14.8), Fetal gut (7.3), Fetal heart (6.5), and Fetal Liver (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPX7 Gene



SOURCE GeneReport for Unigene cluster for GPX7 Gene Hs.43728

mRNA Expression by UniProt/SwissProt for GPX7 Gene

Q96SL4-GPX7_HUMAN
Tissue specificity: Expressed in esophageal epithelial cells; expression is up-regulated after exposure to acidic bile acids.
genes like me logo Genes that share expression patterns with GPX7: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for GPX7 Gene

Orthologs for GPX7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GPX7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPX7 35
  • 91.82 (n)
  • 96.41 (a)
GPX7 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPX7 35
  • 85.39 (n)
  • 89.04 (a)
GPX7 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpx7 35
  • 88.49 (n)
  • 90.48 (a)
Gpx7 16
Gpx7 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPX7 35
  • 99.11 (n)
  • 100 (a)
GPX7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpx7 35
  • 88.89 (n)
  • 91.67 (a)
oppossum
(Monodelphis domestica)
Mammalia GPX7 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPX7 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPX7 35
  • 70.83 (n)
  • 79.76 (a)
GPX7 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPX7 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpx7 35
  • 70.44 (n)
  • 77.38 (a)
zebrafish
(Danio rerio)
Actinopterygii gpx7 35
  • 69.06 (n)
  • 71.86 (a)
gpx7 36
  • 63 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gpx-4 36
  • 25 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL039C 35
  • 54.87 (n)
  • 43.85 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F06732g 35
  • 47.71 (n)
  • 39.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HYR1 35
  • 49.46 (n)
  • 38.71 (a)
GPX1 36
  • 33 (a)
ManyToMany
GPX2 36
  • 36 (a)
ManyToMany
HYR1 36
  • 35 (a)
ManyToMany
GPX2 38
bread mold
(Neurospora crassa)
Ascomycetes NCU09534 35
  • 53.97 (n)
  • 44.22 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gpx1 35
  • 45.7 (n)
  • 37.75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for GPX7:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPX7 Gene

ENSEMBL:
Gene Tree for GPX7 (if available)
TreeFam:
Gene Tree for GPX7 (if available)

Paralogs for GPX7 Gene

Paralogs for GPX7 Gene

(4) SIMAP similar genes for GPX7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPX7: view

Variants for GPX7 Gene

Sequence variations from dbSNP and Humsavar for GPX7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs946154 -- 52,607,655(+) AGCAA(C/G)AGTGC intron-variant
rs946155 -- 52,607,725(+) ATGTT(G/T)ATTTT intron-variant
rs1047619 -- 52,608,740(+) CTGTA(A/G)ACTGG utr-variant-3-prime
rs1047635 -- 52,608,860(+) ATAAA(A/C)CAAAA utr-variant-3-prime
rs1416093 -- 52,601,362(+) ACCAG(C/T)CTGTG upstream-variant-2KB

Variation tolerance for GPX7 Gene

Residual Variation Intolerance Score: 73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.09% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for GPX7 Gene

Disorders for GPX7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPX7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
childhood kidney cell carcinoma
  • pediatric renal cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search GPX7 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

GPX7_HUMAN
  • Barrett esophagus (BE) [MIM:614266]: A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. {ECO:0000269 PubMed:22157330}. Note=The disease is caused by mutations affecting the gene represented in this entry. The pathologic mechanisms leading to Barrett esophagus involve GPX7 dysfunction that results in higher levels of hydrogen peroxide and ROS-induced oxidative stress and DNA damage in esophageal cells.

Relevant External Links for GPX7

Genetic Association Database (GAD)
GPX7
Human Genome Epidemiology (HuGE) Navigator
GPX7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPX7
genes like me logo Genes that share disorders with GPX7: view

No data available for Genatlas for GPX7 Gene

Publications for GPX7 Gene

  1. Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells. (PMID: 22157330) Peng D. … El-Rifai W. (Gut 2012) 3 4 67
  2. Apoptosis induced by oxidized lipids is associated with up-regulation of p66Shc in intestinal Caco-2 cells: protective effects of phenolic compounds. (PMID: 17588737) Giovannini C. … Masella R. (J. Nutr. Biochem. 2008) 25 26
  3. Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells. (PMID: 15294905) Utomo A. … Lee W.H. (J. Biol. Chem. 2004) 2 3
  4. Candidate pathway-based genetic association study of platinum and platinum-taxane related toxicity in a cohort of primary lung cancer patients. (PMID: 25586538) Johnson C. … Yang P. (J. Neurol. Sci. 2015) 3
  5. Glutathione peroxidase 7 has potential tumour suppressor functions that are silenced by location-specific methylation in oesophageal adenocarcinoma. (PMID: 23580780) Peng D. … El-Rifai W. (Gut 2014) 3

Products for GPX7 Gene

Sources for GPX7 Gene

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