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Aliases for GPX6 Gene

Aliases for GPX6 Gene

  • Glutathione Peroxidase 6 2 3
  • Glutathione Peroxidase 6 (Olfactory) 2 3
  • Glutathione Peroxidase Pseudogene 3 2 3
  • EC 1.11.1.9 4 63
  • GSHPx-6 3 4
  • GPx-6 3 4
  • DJ1186N24.1 3
  • DJ1186N24 3
  • EC 1.11.1 63
  • GPX5p 3
  • GPXP3 3

External Ids for GPX6 Gene

Previous HGNC Symbols for GPX6 Gene

  • GPXP3

Previous GeneCards Identifiers for GPX6 Gene

  • GC00U990129
  • GC06M028541
  • GC06P028601
  • GC06M028579
  • GC06M028471
  • GC06M028277

Summaries for GPX6 Gene

Entrez Gene Summary for GPX6 Gene

  • This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Expression of this gene is restricted to embryos and adult olfactory epithelium. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPX6 Gene

GPX6 (Glutathione Peroxidase 6) is a Protein Coding gene. Diseases associated with GPX6 include steatitis and sulfhemoglobinemia. Among its related pathways are Insulin secretion and Selenium Metabolism and Selenoproteins. GO annotations related to this gene include glutathione peroxidase activity. An important paralog of this gene is GPX4.

Gene Wiki entry for GPX6 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPX6 Gene

Genomics for GPX6 Gene

Regulatory Elements for GPX6 Gene

Genomic Location for GPX6 Gene

Chromosome:
6
Start:
28,503,296 bp from pter
End:
28,528,215 bp from pter
Size:
24,920 bases
Orientation:
Minus strand

Genomic View for GPX6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPX6 Gene

Proteins for GPX6 Gene

  • Protein details for GPX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59796-GPX6_HUMAN
    Recommended name:
    Glutathione peroxidase 6
    Protein Accession:
    P59796
    Secondary Accessions:
    • Q4PJ17

    Protein attributes for GPX6 Gene

    Size:
    221 amino acids
    Molecular mass:
    24971 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPX6 Gene

Proteomics data for GPX6 Gene at MOPED

Post-translational modifications for GPX6 Gene

No Post-translational modifications

Other Protein References for GPX6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GPX6 Gene

Protein Domains for GPX6 Gene

Suggested Antigen Peptide Sequences for GPX6 Gene

Graphical View of Domain Structure for InterPro Entry

P59796

UniProtKB/Swiss-Prot:

GPX6_HUMAN :
  • Belongs to the glutathione peroxidase family.
Family:
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX6: view

No data available for Gene Families for GPX6 Gene

Function for GPX6 Gene

Molecular function for GPX6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O

Enzyme Numbers (IUBMB) for GPX6 Gene

Gene Ontology (GO) - Molecular Function for GPX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004602 glutathione peroxidase activity IEA --
genes like me logo Genes that share ontologies with GPX6: view

Phenotypes for GPX6 Gene

genes like me logo Genes that share phenotypes with GPX6: view

Animal Model Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for GPX6 Gene

Localization for GPX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPX6 Gene COMPARTMENTS Subcellular localization image for GPX6 gene
Compartment Confidence
cytosol 3
extracellular 3
mitochondrion 3
endoplasmic reticulum 2
lysosome 2
nucleus 2
peroxisome 2
plasma membrane 2
vacuole 2
chloroplast 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GPX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with GPX6: view

Pathways & Interactions for GPX6 Gene

genes like me logo Genes that share pathways with GPX6: view

Pathways by source for GPX6 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for GPX6 Gene

Gene Ontology (GO) - Biological Process for GPX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with GPX6: view

No data available for SIGNOR curated interactions for GPX6 Gene

Drugs & Compounds for GPX6 Gene

(3) Drugs for GPX6 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target, cofactor 0
Hydrogen peroxide Pharma 42
Selenium Pharma 161

(7) Additional Compounds for GPX6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15(S)-HETE
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoic acid
54845-95-3
15(S)-HPETE
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • 15-Hydroperoxyeicosatetraenoate
  • 15-Hydroperoxyeicosatetraenoic acid
  • 15-Hydroperoxyicosatetraenoate
70981-96-3
5(S)-Hydroperoxyeicosatetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
71774-08-8
5-HETE
  • 5(S)-HETE
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5(S)-Hydroxyeicosatetraenoate
  • 5(S)-Hydroxyeicosatetraenoic acid
70608-72-9
5-Hpete
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-HPETE
74581-83-2
genes like me logo Genes that share compounds with GPX6: view

Transcripts for GPX6 Gene

mRNA/cDNA for GPX6 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPX6 Gene

Glutathione peroxidase 6 (olfactory):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPX6 Gene

No ASD Table

Relevant External Links for GPX6 Gene

GeneLoc Exon Structure for
GPX6
ECgene alternative splicing isoforms for
GPX6

Expression for GPX6 Gene

mRNA expression in normal human tissues for GPX6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPX6 Gene

This gene is overexpressed in Testis (x43.1).

SOURCE GeneReport for Unigene cluster for GPX6 Gene Hs.448570

mRNA Expression by UniProt/SwissProt for GPX6 Gene

P59796-GPX6_HUMAN
Tissue specificity: Expressed in olfactory epithelium and embryos.
genes like me logo Genes that share expression patterns with GPX6: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPX6 Gene

Orthologs for GPX6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPX6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPX6 35
  • 87.33 (n)
  • 83.71 (a)
GPX6 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPX6 35
  • 88.61 (n)
  • 85.15 (a)
GPX6 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpx6 35
  • 81 (n)
  • 71.95 (a)
Gpx6 16
Gpx6 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPX6 35
  • 98.94 (n)
  • 97.29 (a)
GPX6 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpx6 35
  • 79.64 (n)
  • 73.3 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves GPX3 36
  • 58 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii gpx3 36
  • 54 (a)
OneToMany
Species with no ortholog for GPX6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPX6 Gene

ENSEMBL:
Gene Tree for GPX6 (if available)
TreeFam:
Gene Tree for GPX6 (if available)

Paralogs for GPX6 Gene

Paralogs for GPX6 Gene

(4) SIMAP similar genes for GPX6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GPX6: view

Variants for GPX6 Gene

Sequence variations from dbSNP and Humsavar for GPX6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs974334 -- 28,506,441(+) GTGGA(C/G)AATGA intron-variant
rs2071966 -- 28,505,548(+) TCTAC(G/T)TAAAG intron-variant
rs2078422 -- 28,508,720(+) gagaa(C/T)agctt intron-variant
rs2531824 -- 28,502,816(+) cttac(A/C)cccaa downstream-variant-500B
rs2859358 -- 28,505,044(+) AGTTG(A/T)ACCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPX6 Gene

Variant ID Type Subtype PubMed ID
nsv830621 CNV Gain 17160897

Variation tolerance for GPX6 Gene

Residual Variation Intolerance Score: 92.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.94; 67.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPX6 Gene

HapMap Linkage Disequilibrium report
GPX6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPX6 Gene

Disorders for GPX6 Gene

MalaCards: The human disease database

(8) MalaCards diseases for GPX6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
steatitis
sulfhemoglobinemia
  • sulfemoglobinemia
vitreous syneresis
  • vitreous degeneration
swayback
  • swayback of sheep
hemoglobin c disease
  • hb-c disease
- elite association
Search GPX6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPX6

Genetic Association Database (GAD)
GPX6
Human Genome Epidemiology (HuGE) Navigator
GPX6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPX6
genes like me logo Genes that share disorders with GPX6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPX6 Gene

Publications for GPX6 Gene

  1. Apoptosis induced by oxidized lipids is associated with up-regulation of p66Shc in intestinal Caco-2 cells: protective effects of phenolic compounds. (PMID: 17588737) Giovannini C. … Masella R. (J. Nutr. Biochem. 2008) 25 26
  2. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  3. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  4. Glutathione peroxidases and redox-regulated transcription factors. (PMID: 17081103) Brigelius-FlohAc R. (Biol. Chem. 2006) 25 26
  5. Activities of some antioxidative and hexose monophosphate shunt enzymes of skeletal muscle in neuromuscular diseases. (PMID: 3532684) MyllylAo V. … Vihko V. (Acta Neurol. Scand. 1986) 25 26

Products for GPX6 Gene

Sources for GPX6 Gene

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