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Aliases for GPX5 Gene

Aliases for GPX5 Gene

  • Glutathione Peroxidase 5 2 3 4 5
  • Epididymis-Specific Glutathione Peroxidase-Like Protein 3 4
  • Epididymal Androgen-Related Protein 2 3
  • EC 1.11.1.9 4 63
  • GSHPx-5 3 4
  • GPx-5 3 4
  • EGLP 3 4
  • Epididymis Secretory Sperm Binding Protein Li 75p 3
  • HEL-S-75p 3
  • EC 1.11.1 63

External Ids for GPX5 Gene

Previous GeneCards Identifiers for GPX5 Gene

  • GC06P028551
  • GC06P028602
  • GC06P028603
  • GC06P028604
  • GC06P028300

Summaries for GPX5 Gene

Entrez Gene Summary for GPX5 Gene

  • This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike mRNAs for other characterized glutathione peroxidases, this mRNA does not contain a selenocysteine (UGA) codon. Thus, the encoded protein is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for GPX5 Gene

GPX5 (Glutathione Peroxidase 5) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Insulin secretion. GO annotations related to this gene include glutathione peroxidase activity. An important paralog of this gene is GPX4.

UniProtKB/Swiss-Prot for GPX5 Gene

  • Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.

Gene Wiki entry for GPX5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPX5 Gene

Genomics for GPX5 Gene

Regulatory Elements for GPX5 Gene

Genomic Location for GPX5 Gene

Chromosome:
6
Start:
28,525,925 bp from pter
End:
28,534,952 bp from pter
Size:
9,028 bases
Orientation:
Plus strand

Genomic View for GPX5 Gene

Genes around GPX5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPX5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPX5 Gene

Proteins for GPX5 Gene

  • Protein details for GPX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75715-GPX5_HUMAN
    Recommended name:
    Epididymal secretory glutathione peroxidase
    Protein Accession:
    O75715
    Secondary Accessions:
    • A1A4Y0

    Protein attributes for GPX5 Gene

    Size:
    221 amino acids
    Molecular mass:
    25202 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GPX5 Gene

    Alternative splice isoforms for GPX5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPX5 Gene

Proteomics data for GPX5 Gene at MOPED

Post-translational modifications for GPX5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPX5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GPX5 Gene

Protein Domains for GPX5 Gene

Suggested Antigen Peptide Sequences for GPX5 Gene

Graphical View of Domain Structure for InterPro Entry

O75715

UniProtKB/Swiss-Prot:

GPX5_HUMAN :
  • Belongs to the glutathione peroxidase family.
Family:
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX5: view

No data available for Gene Families for GPX5 Gene

Function for GPX5 Gene

Molecular function for GPX5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
UniProtKB/Swiss-Prot Function:
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.

Enzyme Numbers (IUBMB) for GPX5 Gene

genes like me logo Genes that share phenotypes with GPX5: view

Animal Models for GPX5 Gene

MGI Knock Outs for GPX5:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPX5 Gene

Localization for GPX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPX5 Gene COMPARTMENTS Subcellular localization image for GPX5 gene
Compartment Confidence
extracellular 5
chloroplast 2
cytosol 2
mitochondrion 2
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GPX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with GPX5: view

Pathways & Interactions for GPX5 Gene

genes like me logo Genes that share pathways with GPX5: view

Pathways by source for GPX5 Gene

1 GeneGo (Thomson Reuters) pathway for GPX5 Gene

Interacting Proteins for GPX5 Gene

Gene Ontology (GO) - Biological Process for GPX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process NAS 9639555
GO:0006979 response to oxidative stress IEA --
GO:0034599 cellular response to oxidative stress IEA --
GO:0098869 cellular oxidant detoxification IEA,TAS --
genes like me logo Genes that share ontologies with GPX5: view

No data available for SIGNOR curated interactions for GPX5 Gene

Drugs & Compounds for GPX5 Gene

(6) Drugs for GPX5 Gene - From: HMDB, DrugBank, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target, cofactor 0
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 1885
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum 2540
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1881
Hydrogen peroxide Pharma 46

(9) Additional Compounds for GPX5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15(S)-HETE
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoic acid
54845-95-3
15(S)-HPETE
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • 15-Hydroperoxyeicosatetraenoate
  • 15-Hydroperoxyeicosatetraenoic acid
  • 15-Hydroperoxyicosatetraenoate
70981-96-3
5(S)-Hydroperoxyeicosatetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
71774-08-8
5-HETE
  • 5(S)-HETE
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5(S)-Hydroxyeicosatetraenoate
  • 5(S)-Hydroxyeicosatetraenoic acid
70608-72-9
5-Hpete
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-HPETE
74581-83-2
genes like me logo Genes that share compounds with GPX5: view

Transcripts for GPX5 Gene

mRNA/cDNA for GPX5 Gene

(10) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPX5 Gene

Glutathione peroxidase 5 (epididymal androgen-related protein):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPX5 Gene

No ASD Table

Relevant External Links for GPX5 Gene

GeneLoc Exon Structure for
GPX5
ECgene alternative splicing isoforms for
GPX5

Expression for GPX5 Gene

mRNA expression in normal human tissues for GPX5 Gene

mRNA differential expression in normal tissues according to GTEx for GPX5 Gene

This gene is overexpressed in Testis (x50.3).

Protein differential expression in normal tissues from HIPED for GPX5 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPX5 Gene



SOURCE GeneReport for Unigene cluster for GPX5 Gene Hs.248129

mRNA Expression by UniProt/SwissProt for GPX5 Gene

O75715-GPX5_HUMAN
Tissue specificity: Epididymis.
genes like me logo Genes that share expression patterns with GPX5: view

Protein tissue co-expression partners for GPX5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GPX5 Gene

Orthologs for GPX5 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPX5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPX5 35
  • 84.32 (n)
  • 79 (a)
GPX5 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPX5 35
  • 81 (n)
  • 76.92 (a)
GPX5 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpx5 35
  • 81.97 (n)
  • 76.36 (a)
Gpx5 16
Gpx5 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpx5 35
  • 82.42 (n)
  • 75.45 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia GPX5 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPX3 36
  • 60 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii gpx3 36
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C11E4.1 37
  • 37 (a)
C11E4.2 37
  • 39 (a)
Y94H6A.4 35
  • 49.62 (n)
  • 46.59 (a)
Species with no ortholog for GPX5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GPX5 Gene

ENSEMBL:
Gene Tree for GPX5 (if available)
TreeFam:
Gene Tree for GPX5 (if available)

Paralogs for GPX5 Gene

Paralogs for GPX5 Gene

(5) SIMAP similar genes for GPX5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPX5: view

Variants for GPX5 Gene

Sequence variations from dbSNP and Humsavar for GPX5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs769188 - 28,531,789(+) ATGCA(C/G)TCCAG intron-variant, reference, missense
rs58554303 - 28,531,790(+) TGCAC(C/T)CCAGG intron-variant, reference, missense
rs426922 -- 28,534,411(+) GGAAA(C/T)CTAAA utr-variant-3-prime
rs440481 -- 28,531,459(+) AAAGA(A/C)GACTA intron-variant
rs442174 -- 28,524,330(+) AGGGG(A/T)CCAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPX5 Gene

Variant ID Type Subtype PubMed ID
nsv830621 CNV Gain 17160897

Variation tolerance for GPX5 Gene

Residual Variation Intolerance Score: 85.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPX5 Gene

HapMap Linkage Disequilibrium report
GPX5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPX5 Gene

Disorders for GPX5 Gene

Relevant External Links for GPX5

Genetic Association Database (GAD)
GPX5
Human Genome Epidemiology (HuGE) Navigator
GPX5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPX5

No disorders were found for GPX5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPX5 Gene

Publications for GPX5 Gene

  1. The majority of human glutathione peroxidase type 5 (GPX5) transcripts are incorrectly spliced: implications for the role of GPX5 in the male reproductive tract. (PMID: 9639555) Hall L. … Jury J.A. (Biochem. J. 1998) 2 3 4 23 67
  2. Crystal structures of a poplar thioredoxin peroxidase that exhibits the structure of glutathione peroxidases: insights into redox-driven conformational changes. (PMID: 17531267) Koh C.S. … Corbier C. (J. Mol. Biol. 2007) 23 25 26
  3. Extracellular HIV-1 viral protein R affects astrocytic glyceraldehyde 3-phosphate dehydrogenase activity and neuronal survival. (PMID: 23728617) Ferrucci A. … Wigdahl B. (J. Neurovirol. 2013) 3
  4. Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. (PMID: 20200426) Moyer A.M. … Weinshilboum R.M. (Cancer Epidemiol. Biomarkers Prev. 2010) 3
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3

Products for GPX5 Gene

Sources for GPX5 Gene

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