Aliases for GPX5 Gene
External Ids for GPX5 Gene
Previous GeneCards Identifiers for GPX5 Gene
This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike mRNAs for other characterized glutathione peroxidases, this mRNA does not contain a selenocysteine (UGA) codon. Thus, the encoded protein is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2008]
GeneCards Summary for GPX5 Gene
GPX5 (Glutathione Peroxidase 5) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Detoxification of Reactive Oxygen Species. GO annotations related to this gene include glutathione peroxidase activity. An important paralog of this gene is GPX3.
UniProtKB/Swiss-Prot for GPX5 Gene
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.