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Aliases for GPX5 Gene

Aliases for GPX5 Gene

  • Glutathione Peroxidase 5 2 3 4 5
  • Epididymis-Specific Glutathione Peroxidase-Like Protein 3 4
  • Epididymal Androgen-Related Protein 2 3
  • EC 1.11.1.9 4 61
  • GSHPx-5 3 4
  • GPx-5 3 4
  • EGLP 3 4
  • Epididymis Secretory Sperm Binding Protein Li 75p 3
  • Epididymal Secretory Glutathione Peroxidase 3
  • HEL-S-75p 3
  • EC 1.11.1 61

External Ids for GPX5 Gene

Previous GeneCards Identifiers for GPX5 Gene

  • GC06P028551
  • GC06P028602
  • GC06P028603
  • GC06P028604
  • GC06P028300

Summaries for GPX5 Gene

Entrez Gene Summary for GPX5 Gene

  • This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several other characterized glutathione peroxidases, this enzyme is not a selenoprotein, lacking the selenocysteine residue. Thus, it is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]

GeneCards Summary for GPX5 Gene

GPX5 (Glutathione Peroxidase 5) is a Protein Coding gene. Among its related pathways are Glutathione metabolism and Cellular Senescence. GO annotations related to this gene include glutathione peroxidase activity. An important paralog of this gene is GPX3.

UniProtKB/Swiss-Prot for GPX5 Gene

  • Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.

Gene Wiki entry for GPX5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPX5 Gene

Genomics for GPX5 Gene

Regulatory Elements for GPX5 Gene

Enhancers for GPX5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G028747 1.6 Ensembl ENCODE dbSUPER 9.2 +221.8 221761 1.1 CREB3L1 ARNT SIN3A ZNF2 ZNF766 CBX5 FOS ZNF263 SP3 ZHX2 TRIM27 ZKSCAN3 ZNF602P ENSG00000261839 ZFP57 ZKSCAN4 ZSCAN16-AS1 ZKSCAN8 ZNF603P ZNF192P1
GH06G028596 1.4 Ensembl ENCODE 10.5 +71.9 71879 1.8 PKNOX1 MLX ARNT FEZF1 DMAP1 ZNF2 ZNF766 CBX5 ZNF143 FOS ZNF603P ZKSCAN8 ZSCAN26 ZSCAN23 ZSCAN9 ZKSCAN3 ZKSCAN4 GPX5 OR2E1P COX11P1
GH06G028553 1.3 Ensembl ENCODE 11.2 +28.1 28086 1.5 HDGF PKNOX1 CREB3L1 ARNT YBX1 YY1 ZNF766 KLF13 ZHX2 MXD4 ZNF603P ZSCAN23 GPX5 OR2E1P COX11P1 ZBED9 TRR-TCG5-1 GC06M028544 PIR44110
GH06G028673 1.3 Ensembl ENCODE 10.5 +148.3 148324 1.1 ATF1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 GTF3C2 FOS ZKSCAN3 ZNF603P ZKSCAN4 ZKSCAN8 GPX5 GPX6 ZBED9 TRA-CGC2-1 GC06M028676 PIR43008
GH06G028474 1.3 Ensembl ENCODE 10.2 -51.0 -50993 1.3 FOXA2 PKNOX1 CREB3L1 ARNT SIN3A ARID4B ZNF2 SLC30A9 ZNF207 FOS ZKSCAN3 COX11P1 ZSCAN23 ZKSCAN4 ZKSCAN8 GPX6 GPX5 ZNF311 ZNF602P TRT-TGT1-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPX5 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPX5 Gene

Chromosome:
6
Start:
28,525,925 bp from pter
End:
28,534,952 bp from pter
Size:
9,028 bases
Orientation:
Plus strand

Genomic View for GPX5 Gene

Genes around GPX5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPX5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPX5 Gene

Proteins for GPX5 Gene

  • Protein details for GPX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75715-GPX5_HUMAN
    Recommended name:
    Epididymal secretory glutathione peroxidase
    Protein Accession:
    O75715
    Secondary Accessions:
    • A1A4Y0

    Protein attributes for GPX5 Gene

    Size:
    221 amino acids
    Molecular mass:
    25202 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GPX5 Gene

    Alternative splice isoforms for GPX5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPX5 Gene

Selected DME Specific Peptides for GPX5 Gene

O75715:
  • QYPELNALQ
  • LKYVRPGGGF
  • KGDVNGE
  • WNFEKFL
  • ELNALQE
  • WNFEKFLVG
  • NQFGKQEPG
  • LVVLGFPC
  • EILPGLKYVRPG
  • FPCNQFG
  • VNVATYC

Post-translational modifications for GPX5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPX5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GPX5 Gene

Protein Domains for GPX5 Gene

Suggested Antigen Peptide Sequences for GPX5 Gene

Graphical View of Domain Structure for InterPro Entry

O75715

UniProtKB/Swiss-Prot:

GPX5_HUMAN :
  • Belongs to the glutathione peroxidase family.
Family:
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX5: view

No data available for Gene Families for GPX5 Gene

Function for GPX5 Gene

Molecular function for GPX5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
UniProtKB/Swiss-Prot Function:
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.

Enzyme Numbers (IUBMB) for GPX5 Gene

Gene Ontology (GO) - Molecular Function for GPX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity IEA --
GO:0004602 glutathione peroxidase activity TAS --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with GPX5: view
genes like me logo Genes that share phenotypes with GPX5: view

Animal Models for GPX5 Gene

MGI Knock Outs for GPX5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPX5 Gene

Localization for GPX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPX5 gene
Compartment Confidence
extracellular 5
plasma membrane 2
mitochondrion 2
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GPX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0097524 sperm plasma membrane IEA --
genes like me logo Genes that share ontologies with GPX5: view

Pathways & Interactions for GPX5 Gene

genes like me logo Genes that share pathways with GPX5: view

Pathways by source for GPX5 Gene

1 GeneGo (Thomson Reuters) pathway for GPX5 Gene

Interacting Proteins for GPX5 Gene

Gene Ontology (GO) - Biological Process for GPX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process NAS 9639555
GO:0006979 response to oxidative stress IEA --
GO:0034599 cellular response to oxidative stress IEA,TAS --
GO:0055114 oxidation-reduction process IEA --
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with GPX5: view

No data available for SIGNOR curated interactions for GPX5 Gene

Drugs & Compounds for GPX5 Gene

(7) Drugs for GPX5 Gene - From: DrugBank, PharmGKB, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target, cofactor 0
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 2050
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2770
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 2018
Selenium Approved, Vet_approved Pharma 180

(8) Additional Compounds for GPX5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15(S)-HETE
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoic acid
54845-95-3
15(S)-HPETE
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • 15-Hydroperoxyeicosatetraenoate
  • 15-Hydroperoxyeicosatetraenoic acid
  • 15-Hydroperoxyicosatetraenoate
70981-96-3
5(S)-Hydroperoxyeicosatetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
71774-08-8
5-HETE
  • 5(S)-HETE
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5(S)-Hydroxyeicosatetraenoate
  • 5(S)-Hydroxyeicosatetraenoic acid
70608-72-9
5-Hpete
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-HPETE
74581-83-2
genes like me logo Genes that share compounds with GPX5: view

Transcripts for GPX5 Gene

mRNA/cDNA for GPX5 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPX5 Gene

Glutathione peroxidase 5 (epididymal androgen-related protein):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPX5 Gene

No ASD Table

Relevant External Links for GPX5 Gene

GeneLoc Exon Structure for
GPX5
ECgene alternative splicing isoforms for
GPX5

Expression for GPX5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPX5 Gene

mRNA differential expression in normal tissues according to GTEx for GPX5 Gene

This gene is overexpressed in Testis (x50.3).

Protein differential expression in normal tissues from HIPED for GPX5 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPX5 Gene



Protein tissue co-expression partners for GPX5 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPX5 Gene:

GPX5

SOURCE GeneReport for Unigene cluster for GPX5 Gene:

Hs.248129

mRNA Expression by UniProt/SwissProt for GPX5 Gene:

O75715-GPX5_HUMAN
Tissue specificity: Epididymis.
genes like me logo Genes that share expression patterns with GPX5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPX5 Gene

Orthologs for GPX5 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPX5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPX5 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPX5 34 35
  • 84.32 (n)
rat
(Rattus norvegicus)
Mammalia Gpx5 34
  • 82.42 (n)
mouse
(Mus musculus)
Mammalia Gpx5 34 16 35
  • 81.97 (n)
dog
(Canis familiaris)
Mammalia GPX5 34 35
  • 81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 65 (a)
OneToMany
chicken
(Gallus gallus)
Aves GPX3 35
  • 60 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii gpx3 35
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y94H6A.4 34
  • 49.62 (n)
C11E4.2 36
  • 39 (a)
C11E4.1 36
  • 37 (a)
Species where no ortholog for GPX5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GPX5 Gene

ENSEMBL:
Gene Tree for GPX5 (if available)
TreeFam:
Gene Tree for GPX5 (if available)

Paralogs for GPX5 Gene

Paralogs for GPX5 Gene

(5) SIMAP similar genes for GPX5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPX5: view

Variants for GPX5 Gene

Sequence variations from dbSNP and Humsavar for GPX5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs386352313 Uncertain significance 28,526,041(+) TCCAT(C/T)TGCTT reference, synonymous-codon
rs1000182346 -- 28,530,724(+) GAATC(G/T)ATTTA intron-variant
rs1000423731 -- 28,531,094(+) GATTT(A/C)TCTGT intron-variant
rs1000433964 -- 28,529,605(+) TCCTG(A/G)TAAGA splice-donor-variant
rs1000744226 -- 28,524,898(+) ACACA(G/T)AGAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPX5 Gene

Variant ID Type Subtype PubMed ID
dgv3296n106 CNV deletion 24896259
esv3576110 CNV gain 25503493
nsv1074388 CNV deletion 25765185
nsv601210 CNV gain 21841781
nsv601211 CNV loss 21841781
nsv830621 CNV gain 17160897

Variation tolerance for GPX5 Gene

Residual Variation Intolerance Score: 85.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPX5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPX5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPX5 Gene

Disorders for GPX5 Gene

Relevant External Links for GPX5

Genetic Association Database (GAD)
GPX5
Human Genome Epidemiology (HuGE) Navigator
GPX5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPX5

No disorders were found for GPX5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPX5 Gene

Publications for GPX5 Gene

  1. The majority of human glutathione peroxidase type 5 (GPX5) transcripts are incorrectly spliced: implications for the role of GPX5 in the male reproductive tract. (PMID: 9639555) Hall L. … Jury J.A. (Biochem. J. 1998) 2 3 4 22 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. (PMID: 20200426) Moyer A.M. … Weinshilboum R.M. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64
  4. Crystal structures of a poplar thioredoxin peroxidase that exhibits the structure of glutathione peroxidases: insights into redox-driven conformational changes. (PMID: 17531267) Koh C.S. … Corbier C. (J. Mol. Biol. 2007) 22 25 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64

Products for GPX5 Gene

Sources for GPX5 Gene

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