GPX4 Gene
protein-coding GIFtS: 69
GCID: GC19P001103
|
|
glutathione peroxidase 4(Previous name: glutathione peroxidase 4 (phospholipid hydroperoxidase)...)
| |
Aliases
for GPX4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Glutathione Peroxidase 41 2 3 | | Phospholipid Hydroperoxidase2 | | PHGPx1 2 3 | | Phospholipid Hydroperoxide Glutathione Peroxidase, Mitochondrial2 | | MCSP1 2 | | SnGPx1 | | GPx-42 3 | | SnPHGPx1 | | GSHPx-42 3 | | Sperm Nucleus Glutathione Peroxidase2 | | EC 1.11.1.123 8 | | EC 1.11.18 | | Glutathione Peroxidase 4 (Phospholipid Hydroperoxidase)1 | | |
Export aliases for GPX4 gene to outside databasesPrevious GC identifers: GC19P001181 GC19P001043 GC19P001054 GC19P000878 |
Summaries
for GPX4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GPX4:
Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides byreduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathioneperoxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine.Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus,mitochondrion, and cytoplasm. In humans, experimental evidence for alternative splicing exists; alternativetranscription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to beexperimentally verified. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: GPX4_HUMAN, P36969Function: Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development andmale fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides.Essential for embryonic development. Protects from radiation and oxidative damage (By similarity)
Gene Wiki entry for GPX4
|
Genomic Views
for GPX4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GPX4 gene promoter:
p53 Sp1
Other transcription factors
Search SABiosciences Chromatin IP Primers for GPX4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPX4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3GPX4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P001103: view genomic region
(about GC identifiers)
Start:
|
1,103,936 bp from pter |
End:
|
1,106,787 bp from pter |
Size:
|
2,852 bases |
Orientation:
|
plus strand |
|
Proteins
for GPX4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GPX4_HUMAN, P36969 (See
protein sequence)Recommended Name: Phospholipid hydroperoxide glutathione peroxidase, mitochondrial precursor Size: 197 amino acids; 22175 Da
Subunit: Monomer. Has a tendency to form higher mass oligomers
Subcellular location: Isoform Mitochondrial: Mitochondrion
Subcellular location: Isoform Cytoplasmic: Cytoplasm
2 PDB 3D structures from  and Proteopedia  for GPX4:2GS3 (3D)
2OBI (3D)
Secondary accessions: O43381 Q6PJ59 Q9UPK2Alternative initiation: 2 isoforms: P36969-1 P36969-2 Explore the universe of human proteins at neXtProt for GPX4: NX_P36969
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P36969
4/10 DME Specific Peptides for GPX4 (P36969) (see all 10)
GPX4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001034936.1 NP_001034937.1 NP_002076.2
ENSEMBL proteins: ENSP00000346103 ENSP00000466872 ENSP00000465828 ENSP00000464989 ENSP00000468349 ENSP00000467900 Reactome Protein details: P36969
Human Recombinant Protein Products for GPX4:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
GPX4 for ontologies About GeneDecksing
GPX4 Antibody Products:
Assay Products for GPX4: |
Protein
Domains /
Families
for GPX4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GPX4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P36969ProtoNet protein and cluster: P36969 1 Blocks protein family: IPB000889 Glutathione peroxidase
UniProtKB/Swiss-Prot: GPX4_HUMAN, P36969Similarity: Belongs to the glutathione peroxidase family |
Function
for GPX4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: GPX4_HUMAN, P36969Function: Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development andmale fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides.Essential for embryonic development. Protects from radiation and oxidative damage (By similarity)Catalytic activity: 2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H(2)O Genatlas biochemistry entry for GPX4:glutathione peroxidase 4,expressed in testis,catabolic pathway of activated oxygen species,free radical detoxification
Enzyme Numbers (IUBMB): EC 1.11.1.121 2 EC 1.11.12
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004602 | glutathione peroxidase activity |
TAS | 9705830 | | GO:0047066 | phospholipid-hydroperoxide glutathione peroxidase activity |
IEA | -- |
GPX4 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for GPX4:
9 MGI mutant phenotypes (inferred from 8 alleles ) (MGI details for Gpx4):
GPX4 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for GPX4: Gpx4tm1Yana Gpx4tm2.1Marc Gpx4tm1Marc Gpx4tm1Prol
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPX4 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPX4 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): GPX4 (NM_001039848) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GPX4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPX4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPX4 |
|
Pathways & Interactions
for GPX4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Glutathione metabolism | | | 2 | Synthesis of 15-eicosatetraenoic acid derivatives | | | 3 | Arachidonic acid metabolism | | | 4 | Metabolism | | | 5 | Selenium Metabolism and Selenoproteins | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for GPX4
2  GeneGo (Thomson Reuters) Pathways for GPX4
5  BioSystems Pathways for GPX4
5/6 
Reactome Pathways for GPX4 (see all 6)
1 
Kegg Pathway (Kegg details for GPX4):
GPX4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GPX4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/56 Interacting proteins for GPX4 (P369693 ENSP000003461034) via UniProtKB, MINT, STRING, and/or I2D (see all 56)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
GPX4 for ontologies About GeneDecksing
|
Drugs & Compounds
for GPX4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
GPX4 for compounds About GeneDecksing
 Browse Tocris compounds for GPX4
10/11 HMDB Compounds for GPX4 (see all 11) About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| 15(S)-HETE | 15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid (see all 17) | 54845-95-3 | -- | | 15(S)-HPETE | (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8) | 70981-96-3 | -- | | 5(S)-Hydroperoxyeicosatetraenoic acid | 5-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid (see all 6) | 71774-08-8 | -- | | 5-HETE | 5(S)-HETE (see all 14) | 70608-72-9 | -- | | 5-HPETE | 5(S)-HPETE (see all 7) | 74581-83-2 | -- | | Glutathione | 5-L-Glutamyl-L-cysteinylglycine (see all 32) | 70-18-8 | -- | | Hydrogen peroxide | Hydrogen peroxide (see all 44) | 7722-84-1 | -- | | Oxidized glutathione | GSSG (see all 4) | 27025-41-8 | -- | | Selenium | selenium (see all 5) | 7782-49-2 | -- | | Selenocysteine | (2R)-2-amino-3-selanylpropanoate (see all 8) | 3614-08-2 | -- |
1 DrugBank Compound for GPX4 About this table
10/51 Novoseek chemical compound relationships for GPX4 gene (see all 51) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| malic acid, diethyl ester |
87.2 |
4 |
10506188 (1), 9442035 (1) |
| selenocysteine |
83.1 |
6 |
16764674 (1), 17634480 (1), 1778506 (1), 9370288 (1) (see all 5) |
| selenium |
82.2 |
74 |
17052796 (4), 14642406 (3), 9914487 (3), 9285063 (2) (see all 36) |
| cholesterol hydroperoxide |
79.2 |
2 |
8679629 (1) |
| selenite |
73.1 |
12 |
17150329 (2), 17052796 (1), 12431787 (1), 14642406 (1) (see all 7) |
| lipid hydroperoxide |
71.6 |
11 |
15256721 (3), 19769463 (2), 15577264 (2), 10560610 (1) |
| linoleic acid hydroperoxide |
71.2 |
2 |
7851631 (2) |
| selenophosphate |
69.2 |
2 |
9359853 (1) |
| 12-hpete |
68.7 |
6 |
17997296 (1), 11115402 (1) |
| 13-hydroperoxyoctadecadienoic acid |
65.7 |
2 |
12218361 (1) |
Search CenterWatch for drugs/clinical trials and news about GPX4
|
Transcripts
for GPX4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GPX4 gene (3 alternative transcripts): NM_001039847.1 NM_001039848.1 NM_002085.3 Unigene Cluster for GPX4: Glutathione peroxidase 4 Hs.433951 [show with all ESTs]Unigene Representative Sequence: BG11586111 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000354171(uc021umf.1 uc021umg.1 uc021umh.1) ENST00000589115
ENST00000589115 ENST00000593032 ENST00000588919 ENST00000588919 ENST00000585362
ENST00000587648 ENST00000592940 ENST00000585480 ENST00000587932
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPX4 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPX4 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): GPX4 (NM_001039848) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GPX4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPX4 |
Additional cDNA sequence: AK225859.1 BC010157.2 BC011836.2 BC021567.1 BC022071.1 BC032695.1 BC039849.1 BC046163.1 BC058329.1 X71973.1 24/25 DOTS entries (see all 25): DT.100638890 DT.455124 DT.95105474 DT.100867363 DT.100688494 DT.95171936 DT.70103777 DT.100867364 DT.91766252 DT.95171922 DT.97862488 DT.100848200 DT.86847533 DT.100045145 DT.121442151 DT.91766251 DT.95171920 DT.100637854 DT.91651583 DT.91766253 DT.91766256 DT.95171921 DT.95208957 DT.97862487 24/870 AceView cDNA sequences (see all 870): BE795966 BC039849 BU845044 BQ962510 BQ109510 F32122 CR618930 BM841534 BU507135 AI371989 BF834757 BG476519 BQ940927 BM664778 CK904844 CA393961 AA662692 BM541349 BX387209 BM928713 BM841416 BE267508 BP370909 AA453376
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GPX4 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | | | - | | | | - | | | | | | - | | | | | | |
| SP3: | | | | | | | - | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for GPX4
|
Expression
for GPX4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GPX4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTGCTGGG
About this image
See GPX4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GPX4
SOURCE GeneReport for Unigene cluster: Hs.433951
UniProtKB/Swiss-Prot: GPX4_HUMAN, P36969Tissue specificity: Present primarily in testis
SABiosciences Expression via Pathway-Focused PCR Arrays including GPX4:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPX4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GPX4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPX4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPX4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPX4 |
Orthologs
for GPX4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for GPX4 gene from 10/37 species (see all 37) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
GPX41 |
glutathione peroxidase 4 (phospholipid hydroperoxidase) |
74.56(n)
76.32(a) |
|
374056 XM_003642871.1 XP_003642919.1 |
lizard
(Anolis carolinensis) |
Reptilia |
GPX46 |
-- |
74(a) |
1 ↔ 1 |
AAWZ02041081(2345-4258) |
African clawed frog
(Xenopus laevis) |
Amphibia |
480278212 |
-- |
74.4(n) |
|
48027821 |
zebrafish
(Danio rerio) |
Actinopterygii |
gpx4b2 |
glutathione peroxidase 4b |
75.25(n) |
|
352929 AY216591.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG120133
PHGPx1 |
glutathione peroxidase3
CG12013-PA1 |
44(a)3
54.33(n)1
41.83(a)1 |
|
63D13
384131 NM_168025.11 NP_728869.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
F26E4.123
R05H10.51 |
glutathione peroxidase3
Protein R05H10.51 |
48(a)
(best of 3)3
57.62(n)1
49.67(a)1 |
|
I(9788403-9789394)3
1876301 NM_064677.31 NP_497078.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
HYR11 |
Hyr1p |
51.88(n)
45.07(a) |
|
854855 NP_012303.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
GPX61 |
glutathione peroxidase |
58.39(n)
51.63(a) |
|
826765 NM_117229.3 NP_192897.2 |
rice
(Oryza sativa) |
Liliopsida |
Os.48332 |
Oryza sativa (japonica cultivar-group) cDNA clone0 more |
77.85(n) |
|
AK105165.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
btuE6 |
glutathione peroxidase |
33(a) |
1 → many |
Chromosome(1791582-1792133) |
ENSEMBL Gene Tree for GPX4 (if available)
TreeFam Gene Tree for GPX4 (if available) |
Paralogs
for GPX4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GPX4 gene
- GPX62 GPX52 GPX22 GPX72 GPX12 GPX82 GPX32
4 SIMAP similar genes for GPX4 using alignment to 8 protein entries: GPX4_HUMAN (see all proteins):GPX7 GPX8 GPX2 GPX1
GPX4 for paralogs About GeneDecksing
|
Genomic Variants
for GPX4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GPX4 (1103936 - 1106787 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for GPX4
5 CNVs: 4066 2237 29682 5065 30885
Human Gene Mutation Database (HGMD): GPX4
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPX4 |
|
Disorders
/ Diseases
for GPX4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GPX4 for disorders About GeneDecksing
OMIM gene information: 138322
OMIM disorders: --
20/44  diseases for GPX4 (see all 44): About MalaCardsspermatic cord torsion type 2 diabetes mellitus keshan disease toxic encephalopathy
diabetes mellitus male infertility cerebral palsy infertility
fanconi's anemia burkitt's lymphoma glanders phenylketonuria
mastitis rheumatoid arthritis down syndrome brain disease
hypercholesterolemia acute pancreatitis breast cancer anemia
1 disease from the University of Copenhagen DISEASES database for GPX4:Male infertility 10/12 Novoseek disease relationships for GPX4 gene (see all 12) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| selenium deficiency |
76.5 |
3 |
10464096 (1), 17937612 (1), 9914487 (1) |
| infertility male |
59.9 |
7 |
20104259 (1), 12193409 (1), 19783653 (1), 17937612 (1) (see all 5) |
| leukemia l1210 |
51.9 |
4 |
7779866 (1), 8342949 (1) |
| cell damage |
19.7 |
4 |
11295525 (2), 9285063 (1) |
| infertility |
19.7 |
7 |
12606444 (1), 15577264 (1), 17937612 (1), 12695510 (1) (see all 5) |
| carcinoma squamous cell |
10.6 |
9 |
10428483 (2), 12958179 (2), 12218361 (1), 10882192 (1) (see all 5) |
| cancer |
8.42 |
14 |
17431126 (3), 15280629 (1), 11295525 (1), 14695942 (1) (see all 7) |
| leukemia |
0 |
3 |
16223606 (1), 1394132 (1) |
| necrosis |
0 |
3 |
17688422 (1) |
| inflammation |
0 |
5 |
16223606 (1), 12490284 (1), 15577264 (1), 12521597 (1) (see all 5) |
Genetic Association Database (GAD): GPX4
Human Genome Epidemiology (HuGE) Navigator: GPX4 (31 documents)
Export disorders for GPX4 gene to outside databases
|
Publications
for GPX4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GPX4 gene, integrated from 9 sources (see all 224):
(articles sorted by number of sources associating them with GPX4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genetic variations of gpx-4 and male infertility in humans. (PubMed id 12606444)1, 2, 4, 9 Maiorino M.... Flohe L. (2003)
- Cloning and sequencing of the cDNA encoding a human testis phospholipid hydroperoxide glutathione peroxidase. (PubMed id 8039723)1, 2, 3 Esworthy R.S.... Chu F.-F. (1994)
- Phospholipid hydroperoxide glutathione peroxidase (PHGPx) expression is downregulated in poorly differentiated breast invasive ductal carcinoma. (PubMed id 17516241)1, 7, 9 Cejas P....Gonzalez-Baron M. (2007)
- Structural basis for catalytic activity and enzyme polymerization of phospholipid hydroperoxide glutathione peroxidase-4 (GPx4). (PubMed id 17630701)1, 2, 9 Scheerer P....Kuhn H. (2007)
- Structural organization of the human selenium-dependent phospholipid hydroperoxide glutathione peroxidase gene (GPX4): chromosomal localization to 19p13.3. (PubMed id 9705830)1, 2, 9 Kelner M.J. and Montoya M.A. (1998)
- Dual function of the selenoprotein PHGPx during sperm maturation. (PubMed id 10464096)1, 3, 9 Ursini F....FlohAc L. (1999)
- The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively. (PubMed id 8287691)1, 3, 9 Chu F.F. (1994)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus. (PubMed id 12732844)1, 4 Watanabe I....Koga T. (2003)
|
External Searches for GPX4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GPX4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GPX4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GPX4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GPX4 | Pharmacogenomics, SNPs, Pathways | | NIEHS-SNPs | http://egp.gs.washington.edu/data/gpx4/ |
|
| | |
About This Section
| Patent Information for GPX4 gene:
Search GeneIP for patents involving GPX4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GPX4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
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| | |  | OriGene Antibodies for GPX4 | | OriGene shRNA RFP for GPX4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GPX4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPX4 | | | OriGene Protein Over-expression Lysate for GPX4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GPX4 | | OriGene 3'-UTR Clone for GPX4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPX4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPX4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPX4 |
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