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Aliases for GPX4 Gene

Aliases for GPX4 Gene

  • Glutathione Peroxidase 4 2 3 4
  • Phospholipid Hydroperoxidase 2 3
  • EC 1.11.1.12 4 63
  • GSHPx-4 3 4
  • GPx-4 3 4
  • PHGPx 3 4
  • Phospholipid Hydroperoxide Glutathione Peroxidase, Mitochondrial 3
  • Glutathione Peroxidase 4 (Phospholipid Hydroperoxidase) 2
  • Sperm Nucleus Glutathione Peroxidase 3
  • EC 1.11.1 63
  • SnPHGPx 3
  • SnGPx 3
  • MCSP 3

External Ids for GPX4 Gene

Previous GeneCards Identifiers for GPX4 Gene

  • GC19P001181
  • GC19P001043
  • GC19P001054
  • GC19P000878

Summaries for GPX4 Gene

Entrez Gene Summary for GPX4 Gene

  • This gene encodes a member of the glutathione peroxidase protein family. Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. The encoded protein has been identified as a moonlighting protein based on its ability to serve dual functions as a peroxidase as well as a structural protein in mature spermatozoa. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for GPX4 Gene

GPX4 (Glutathione Peroxidase 4) is a Protein Coding gene. Diseases associated with GPX4 include spondylometaphyseal dysplasia sedaghatian type and keshan disease. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include glutathione peroxidase activity and phospholipid-hydroperoxide glutathione peroxidase activity. An important paralog of this gene is GPX5.

UniProtKB/Swiss-Prot for GPX4 Gene

  • Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).

Gene Wiki entry for GPX4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPX4 Gene

Genomics for GPX4 Gene

Regulatory Elements for GPX4 Gene

Transcription factor binding sites by QIAGEN in the GPX4 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GPX4 Gene

Start:
1,103,926 bp from pter
End:
1,106,791 bp from pter
Size:
2,866 bases
Orientation:
Plus strand

Genomic View for GPX4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPX4 Gene

Proteins for GPX4 Gene

  • Protein details for GPX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36969-GPX4_HUMAN
    Recommended name:
    Phospholipid hydroperoxide glutathione peroxidase, mitochondrial
    Protein Accession:
    P36969
    Secondary Accessions:
    • O43381
    • Q6PJ59
    • Q9UPK2

    Protein attributes for GPX4 Gene

    Size:
    197 amino acids
    Molecular mass:
    22175 Da
    Quaternary structure:
    • Monomer. Has a tendency to form higher mass oligomers.

    Three dimensional structures from OCA and Proteopedia for GPX4 Gene

    Alternative splice isoforms for GPX4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPX4 Gene

Proteomics data for GPX4 Gene at MOPED

Post-translational modifications for GPX4 Gene

  • Ubiquitination at Lys162 and Lys167
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for GPX4 (Glutathione Peroxidase 4/GPX4)

Domains for GPX4 Gene

Protein Domains for GPX4 Gene

Suggested Antigen Peptide Sequences for GPX4 Gene

Graphical View of Domain Structure for InterPro Entry

P36969

UniProtKB/Swiss-Prot:

GPX4_HUMAN :
  • P36969
Family:
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX4: view

No data available for Gene Families for GPX4 Gene

Function for GPX4 Gene

Molecular function for GPX4 Gene

GENATLAS Biochemistry: glutathione peroxidase 4,expressed in testis,catabolic pathway of activated oxygen species,free radical detoxification
UniProtKB/Swiss-Prot CatalyticActivity: 2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H(2)O
UniProtKB/Swiss-Prot Function: Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).

Enzyme Numbers (IUBMB) for GPX4 Gene

Gene Ontology (GO) - Molecular Function for GPX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004602 glutathione peroxidase activity TAS 9705830
GO:0008430 selenium binding IEA --
GO:0043295 glutathione binding IEA --
GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity IEA --
genes like me logo Genes that share ontologies with GPX4: view
genes like me logo Genes that share phenotypes with GPX4: view

Animal Models for GPX4 Gene

MGI Knock Outs for GPX4:

Animal Model Products

CRISPR Products

miRNA for GPX4 Gene

miRTarBase miRNAs that target GPX4

No data available for Transcription Factor Targeting and HOMER Transcription for GPX4 Gene

Localization for GPX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX4 Gene

Isoform Mitochondrial: Mitochondrion.
Isoform Cytoplasmic: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPX4 Gene COMPARTMENTS Subcellular localization image for GPX4 gene
Compartment Confidence
mitochondrion 5
cytosol 4
extracellular 3
plasma membrane 3
cytoskeleton 2
endoplasmic reticulum 2
nucleus 2
peroxisome 2
vacuole 2
lysosome 1

Gene Ontology (GO) - Cellular Components for GPX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion TAS 9705830
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GPX4: view

Pathways for GPX4 Gene

genes like me logo Genes that share pathways with GPX4: view

PCR Array Products

Gene Ontology (GO) - Biological Process for GPX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS 8039723
GO:0006749 glutathione metabolic process IEA --
GO:0006979 response to oxidative stress IEA --
GO:0007275 multicellular organismal development IEA --
GO:0007568 aging IEA --
genes like me logo Genes that share ontologies with GPX4: view

Compounds for GPX4 Gene

(11) HMDB Compounds for GPX4 Gene

Compound Synonyms Cas Number PubMed IDs
15(S)-HETE
  • 15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid
54845-95-3
15(S)-HPETE
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
70981-96-3
5(S)-Hydroperoxyeicosatetraenoic acid
  • 5-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid
71774-08-8
5-HETE
  • 5(S)-HETE
70608-72-9
5-HPETE
  • 5(S)-HPETE
74581-83-2

(1) Drugbank Compounds for GPX4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Glutathione
  • 5-L-Glutamyl-L-cysteinylglycine
70-18-8 target cofactor

(51) Novoseek inferred chemical compound relationships for GPX4 Gene

Compound -log(P) Hits PubMed IDs
malic acid, diethyl ester 87.2 2
selenocysteine 83.1 5
selenium 82.2 54
cholesterol hydroperoxide 79.2 1
selenite 73.1 8
genes like me logo Genes that share compounds with GPX4: view

Transcripts for GPX4 Gene

Unigene Clusters for GPX4 Gene

Glutathione peroxidase 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPX4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPX4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - -
SP5: -
SP6:
SP7:

Relevant External Links for GPX4 Gene

GeneLoc Exon Structure for
GPX4
ECgene alternative splicing isoforms for
GPX4

Expression for GPX4 Gene

mRNA expression in normal human tissues for GPX4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPX4 Gene

This gene is overexpressed in Testis (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPX4 Gene

SOURCE GeneReport for Unigene cluster for GPX4 Gene Hs.433951

mRNA Expression by UniProt/SwissProt for GPX4 Gene

P36969-GPX4_HUMAN
Tissue specificity: Present primarily in testis
genes like me logo Genes that share expressions with GPX4: view

In Situ Assay Products

Orthologs for GPX4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPX4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPX4 36
  • 76 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPX4 35
  • 89.17 (n)
  • 92.39 (a)
GPX4 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpx4 35
  • 83.42 (n)
  • 88.11 (a)
Gpx4 16
Gpx4 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPX4 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPX4 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpx4 35
  • 86.13 (n)
  • 91.37 (a)
lizard
(Anolis carolinensis)
Reptilia GPX4 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpx4 35
  • 64.94 (n)
  • 67.36 (a)
Str.6328 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.584 35
zebrafish
(Danio rerio)
Actinopterygii gpx4a 36
  • 71 (a)
OneToMany
gpx4b 35
  • 68.78 (n)
  • 69.84 (a)
gpx4b 36
  • 77 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG15116 36
  • 34 (a)
OneToMany
PHGPx 36
  • 34 (a)
OneToMany
CG12013 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea gpx-1 36
  • 44 (a)
OneToMany
gpx-2 36
  • 41 (a)
OneToMany
gpx-6 36
  • 40 (a)
OneToMany
gpx-7 36
  • 37 (a)
OneToMany
T09A12.2 35
  • 50.1 (n)
  • 45.4 (a)
T09A12.2 37
  • 44 (a)
R05H10.5 37
  • 48 (a)
F26E4.12 37
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPX1 36
  • 36 (a)
ManyToMany
GPX2 35
  • 50.54 (n)
  • 43.14 (a)
GPX2 36
  • 41 (a)
ManyToMany
HYR1 36
  • 40 (a)
ManyToMany
soybean
(Glycine max)
eudicotyledons Gma.2160 35
thale cress
(Arabidopsis thaliana)
eudicotyledons GPX7 35
  • 54.47 (n)
  • 51.63 (a)
corn
(Zea mays)
Liliopsida Zm.6203 35
rice
(Oryza sativa)
Liliopsida Os.4833 35
wheat
(Triticum aestivum)
Liliopsida Ta.5358 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
ManyToMany
Species with no ortholog for GPX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for GPX4 Gene

ENSEMBL:
Gene Tree for GPX4 (if available)
TreeFam:
Gene Tree for GPX4 (if available)

Paralogs for GPX4 Gene

Paralogs for GPX4 Gene

Selected SIMAP similar genes for GPX4 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with GPX4: view

Variants for GPX4 Gene

Sequence variations from dbSNP and Humsavar for GPX4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs4851 -- 1,106,636(+) GCACT(C/T)ATGAC reference, missense, utr-variant-3-prime
rs14283 -- 1,106,263(+) TTCAC(C/T)AAGGT reference, synonymous-codon
rs713041 -- 1,106,616(+) GCCCT(C/T)GGAGC synonymous-codon, reference, utr-variant-3-prime
rs757228 -- 1,101,993(+) AACAG(A/G)CTTAT upstream-variant-2KB
rs757229 -- 1,102,115(+) GTGGC(C/G)GGGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPX4 Gene

Variant ID Type Subtype PubMed ID
dgv3513n71 CNV Loss 21882294
dgv3552n71 CNV Loss 21882294
nsv910292 CNV Loss 21882294
nsv910310 CNV Loss 21882294
dgv3555n71 CNV Loss 21882294
nsv9662 CNV Gain 18304495
nsv469845 CNV Loss 16826518
essv258 CNV CNV 17122850
nsv833704 CNV Gain 17160897
dgv1055e1 CNV Complex 17122850
dgv3569n71 CNV Loss 21882294
dgv3574n71 CNV Loss 21882294
dgv3575n71 CNV Loss 21882294
nsv470102 CNV Loss 18288195
dgv3579n71 CNV Loss 21882294
nsv910412 CNV Loss 21882294
nsv910413 CNV Gain 21882294
dgv3580n71 CNV Loss 21882294
nsv470103 CNV Gain 18288195
nsv828366 CNV Loss 20364138
dgv3581n71 CNV Loss 21882294
dgv3582n71 CNV Loss 21882294
nsv910420 CNV Loss 21882294
dgv3583n71 CNV Loss 21882294
dgv3584n71 CNV Loss 21882294
nsv828367 CNV Gain 20364138

Relevant External Links for GPX4 Gene

HapMap Linkage Disequilibrium report
GPX4
Human Gene Mutation Database (HGMD)
GPX4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPX4 Gene

Disorders for GPX4 Gene

UniProtKB/Swiss-Prot

GPX4_HUMAN
  • Spondylometaphyseal dysplasia, Sedaghatian type (SMDS) [MIM:250220]: A form of spondylometaphyseal dysplasia, a group of short stature disorders distinguished by abnormalities in the vertebrae and the metaphyses of the tubular bones. SMDS is a neonatal lethal form characterized by severe metaphyseal chondrodysplasia with mild limb shortening, platyspondyly, cardiac conduction defects, and central nervous system abnormalities. {ECO:0000269 PubMed:24706940}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(12) Novoseek inferred disease relationships for GPX4 Gene

Disease -log(P) Hits PubMed IDs
selenium deficiency 76.5 3
infertility male 59.9 5
leukemia l1210 51.9 2
cell damage 19.7 3
infertility 19.7 5

Relevant External Links for GPX4

Genetic Association Database (GAD)
GPX4
Human Genome Epidemiology (HuGE) Navigator
GPX4
genes like me logo Genes that share disorders with GPX4: view

Publications for GPX4 Gene

  1. Genetic variations of gpx-4 and male infertility in humans. (PMID: 12606444) Maiorino M. … Flohe L. (Biol. Reprod. 2003) 3 4 23 48
  2. Structural basis for catalytic activity and enzyme polymerization of phospholipid hydroperoxide glutathione peroxidase-4 (GPx4). (PMID: 17630701) Scheerer P. … Kuhn H. (Biochemistry 2007) 3 4 23
  3. Common germline genetic variation in antioxidant defense genes and survival after diagnosis of breast cancer. (PMID: 17634480) Udler M. … Pharoah P. (J. Clin. Oncol. 2007) 3 23 48
  4. Functional effects of a common single-nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene: interaction with sex. (PMID: 18400727) MAcplan C. … Hesketh J.E. (Am. J. Clin. Nutr. 2008) 3 23 48
  5. Genetic variants in selenoprotein genes increase risk of colorectal cancer. (PMID: 20378690) MAcplan C. … Hesketh J.E. (Carcinogenesis 2010) 3 23 48

Products for GPX4 Gene

Sources for GPX4 Gene

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