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Aliases for GPX3 Gene

Aliases for GPX3 Gene

  • Glutathione Peroxidase 3 2 3 5
  • Extracellular Glutathione Peroxidase 3 4
  • Glutathione Peroxidase 3 (Plasma) 2 3
  • Plasma Glutathione Peroxidase 3 4
  • EC 1.11.1.9 4 56
  • GSHPx-3 3 4
  • GSHPx-P 3 4
  • GPx-3 3 4
  • GPx-P 3 4
  • EC 1.11.1 56
  • GPXP 4

External Ids for GPX3 Gene

Previous GeneCards Identifiers for GPX3 Gene

  • GC05P150468
  • GC05P150429
  • GC05P150430
  • GC05P150381
  • GC05P145545

Summaries for GPX3 Gene

Entrez Gene Summary for GPX3 Gene

  • The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]

GeneCards Summary for GPX3 Gene

GPX3 (Glutathione Peroxidase 3) is a Protein Coding gene. Diseases associated with GPX3 include Glutathione Peroxidase Deficiency and Pre-Eclampsia. Among its related pathways are Glutathione metabolism and Detoxification of Reactive Oxygen Species. Gene Ontology (GO) annotations related to this gene include transcription factor binding and selenium binding. An important paralog of this gene is GPX6.

UniProtKB/Swiss-Prot for GPX3 Gene

  • Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.

Gene Wiki entry for GPX3 Gene

Additional gene information for GPX3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPX3 Gene

Genomics for GPX3 Gene

GeneHancer (GH) Regulatory Elements for GPX3 Gene

Promoters and enhancers for GPX3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I151019 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 558.5 +3.5 3547 8 FOXA2 PKNOX1 ARID4B SIN3A YY1 SP3 SP5 NFYC MXD4 REST GPX3 ZNF300 ZNF300P1 TCOF1 RPL7P1 G3BP1 RBM22 TNIP1 GC05P151021 GC05P151028
GH05I151147 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 +133.0 133024 12 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF766 ZNF213 ZNF143 ANXA6 GPX3 ENSG00000254298 TNIP1
GH05I151091 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +76.7 76680 10.6 HDGF PKNOX1 SMAD1 FOXA2 ARNT IRF4 YY1 ZNF766 E2F8 ZNF207 TNIP1 ANXA6 GPX3 RBM22 CCDC69 DCTN4 SLC36A1 SMIM3
GH05I151138 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 10.3 +122.1 122149 9.1 SMAD1 BACH1 SIN3A ZMYM3 EBF1 RELA GATA3 POLR2A NFATC1 SCRT2 ANXA6 ZNF300P1 GPX3 TNIP1
GH05I150846 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 10.4 -173.3 -173333 1.4 ATF1 ARID4B SIN3A ZNF2 IRF4 ZNF143 ATF7 RUNX3 JUNB REST IRGM ZNF300P1 SMIM3 DCTN4 GPX3 ZNF300
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPX3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPX3 gene promoter:

Genomic Locations for GPX3 Gene

Genomic Locations for GPX3 Gene
chr5:151,020,438-151,028,993
(GRCh38/hg38)
Size:
8,556 bases
Orientation:
Plus strand
chr5:150,399,999-150,408,554
(GRCh37/hg19)

Genomic View for GPX3 Gene

Genes around GPX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPX3 Gene

Proteins for GPX3 Gene

  • Protein details for GPX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22352-GPX3_HUMAN
    Recommended name:
    Glutathione peroxidase 3
    Protein Accession:
    P22352
    Secondary Accessions:
    • O43787
    • Q86W78
    • Q9NZ74
    • Q9UEL1

    Protein attributes for GPX3 Gene

    Size:
    226 amino acids
    Molecular mass:
    25552 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for GPX3 Gene

neXtProt entry for GPX3 Gene

Selected DME Specific Peptides for GPX3 Gene

P22352:
  • HRTTVSNVKMDILSYMRRQAAL
  • WNFEKFL
  • ELNALQE
  • WNFEKFLVG
  • NQFGKQEPG
  • LKYVRPGGGF
  • KGDVNGE
  • MRWHHRTT
  • LFVNVASYUGLT
  • KSKMDCHGG
  • FPCNQFG

Post-translational modifications for GPX3 Gene

Domains & Families for GPX3 Gene

Gene Families for GPX3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for GPX3 Gene

Suggested Antigen Peptide Sequences for GPX3 Gene

Graphical View of Domain Structure for InterPro Entry

P22352

UniProtKB/Swiss-Prot:

GPX3_HUMAN :
  • Belongs to the glutathione peroxidase family.
Family:
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX3: view

Function for GPX3 Gene

Molecular function for GPX3 Gene

GENATLAS Biochemistry:
glutathione peroxidase 3,plasma,expressed in kidney,lung,breast,placenta,catabolic pathway of activated oxygen species,free radical detoxification
UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
UniProtKB/Swiss-Prot Function:
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.

Enzyme Numbers (IUBMB) for GPX3 Gene

Phenotypes From GWAS Catalog for GPX3 Gene

Gene Ontology (GO) - Molecular Function for GPX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004602 glutathione peroxidase activity IDA,IEA 1897960
GO:0005515 protein binding IPI 25416956
GO:0008134 transcription factor binding TAS 8056346
GO:0008430 selenium binding IDA 2491950
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with GPX3: view
genes like me logo Genes that share phenotypes with GPX3: view

Animal Models for GPX3 Gene

MGI Knock Outs for GPX3:

miRNA for GPX3 Gene

miRTarBase miRNAs that target GPX3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPX3 Gene

Localization for GPX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPX3 gene
Compartment Confidence
extracellular 5
mitochondrion 2
nucleus 2
cytosol 2
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for GPX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA,IEA 1897960
GO:0070062 extracellular exosome IDA,HDA 19199708
genes like me logo Genes that share ontologies with GPX3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPX3 Gene

Pathways & Interactions for GPX3 Gene

genes like me logo Genes that share pathways with GPX3: view

Pathways by source for GPX3 Gene

Gene Ontology (GO) - Biological Process for GPX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IEA --
GO:0006982 response to lipid hydroperoxide TAS 2491950
GO:0034599 cellular response to oxidative stress TAS --
GO:0042744 hydrogen peroxide catabolic process TAS,IEA 2491950
GO:0051289 protein homotetramerization IDA 3693360
genes like me logo Genes that share ontologies with GPX3: view

No data available for SIGNOR curated interactions for GPX3 Gene

Drugs & Compounds for GPX3 Gene

(26) Drugs for GPX3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target, cofactor 0
Selenium Approved, Investigational, Vet_approved Pharma 193
Hydrogen peroxide Approved, Vet_approved Pharma 73
Oxidized glutathione Approved, Experimental, Investigational Pharma 0
Water Approved Pharma 0

(23) Additional Compounds for GPX3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15(S)-HETE
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoic acid
54845-95-3
15(S)-HPETE
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • 15-Hydroperoxyeicosatetraenoate
  • 15-Hydroperoxyeicosatetraenoic acid
  • 15-Hydroperoxyicosatetraenoate
70981-96-3
5(S)-Hydroperoxyeicosatetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
71774-08-8
5-HETE
  • 5(S)-HETE
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5(S)-Hydroxyeicosatetraenoate
  • 5(S)-Hydroxyeicosatetraenoic acid
70608-72-9
5-Hpete
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-HPETE
74581-83-2
genes like me logo Genes that share compounds with GPX3: view

Transcripts for GPX3 Gene

Unigene Clusters for GPX3 Gene

Glutathione peroxidase 3 (plasma):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPX3 Gene

No ASD Table

Relevant External Links for GPX3 Gene

GeneLoc Exon Structure for
GPX3
ECgene alternative splicing isoforms for
GPX3

Expression for GPX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPX3 Gene

mRNA differential expression in normal tissues according to GTEx for GPX3 Gene

This gene is overexpressed in Kidney - Cortex (x9.2), Adipose - Visceral (Omentum) (x4.3), and Adipose - Subcutaneous (x4.1).

Protein differential expression in normal tissues from HIPED for GPX3 Gene

This gene is overexpressed in Vitreous humor (25.7), Kidney (8.2), and Serum (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GPX3 Gene



Protein tissue co-expression partners for GPX3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPX3 Gene:

GPX3

SOURCE GeneReport for Unigene cluster for GPX3 Gene:

Hs.386793

mRNA Expression by UniProt/SwissProt for GPX3 Gene:

P22352-GPX3_HUMAN
Tissue specificity: Secreted in plasma.

Evidence on tissue expression from TISSUES for GPX3 Gene

  • Kidney(5)
  • Eye(4.9)
  • Lung(4.9)
  • Pancreas(4.7)
  • Blood(4.6)
  • Thyroid gland(4.6)
  • Intestine(4.5)
  • Nervous system(4.4)
  • Liver(3.8)
  • Heart(3.5)
  • Muscle(3.3)
  • Spleen(2.4)
  • Gall bladder(2.3)
  • Stomach(2.3)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with GPX3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPX3 Gene

Orthologs for GPX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPX3 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia GPX3 33 34
  • 90.86 (n)
cow
(Bos Taurus)
Mammalia GPX3 33 34
  • 88.2 (n)
rat
(Rattus norvegicus)
Mammalia Gpx3 33
  • 87.61 (n)
mouse
(Mus musculus)
Mammalia Gpx3 33 16 34
  • 87.02 (n)
oppossum
(Monodelphis domestica)
Mammalia GPX3 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves GPX3 33 34
  • 73.93 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpx3 33
  • 65.32 (n)
MGC75694 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.22088 33
zebrafish
(Danio rerio)
Actinopterygii gpx3 33 34
  • 67.92 (n)
worm
(Caenorhabditis elegans)
Secernentea C11E4.2 35
  • 43 (a)
C11E4.1 35
  • 42 (a)
Species where no ortholog for GPX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPX3 Gene

ENSEMBL:
Gene Tree for GPX3 (if available)
TreeFam:
Gene Tree for GPX3 (if available)

Paralogs for GPX3 Gene

Paralogs for GPX3 Gene

(4) SIMAP similar genes for GPX3 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with GPX3: view

Variants for GPX3 Gene

Sequence variations from dbSNP and Humsavar for GPX3 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000129515 -- 151,028,141(+) T/C 3_prime_UTR_variant
rs1000469429 -- 151,019,031(+) A/G upstream_transcript_variant
rs1000521136 -- 151,019,437(+) C/T upstream_transcript_variant
rs1000743591 -- 151,021,971(+) G/A intron_variant
rs1000985869 -- 151,025,828(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPX3 Gene

Variant ID Type Subtype PubMed ID
nsv526224 CNV gain 19592680

Variation tolerance for GPX3 Gene

Residual Variation Intolerance Score: 42.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPX3 Gene

Disorders for GPX3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GPX3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
glutathione peroxidase deficiency
  • gpxd
pre-eclampsia
  • toxemia of pregnancy
anemia of prematurity
- elite association - COSMIC cancer census association via MalaCards
Search GPX3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPX3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPX3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPX3 Gene

Publications for GPX3 Gene

  1. Glutathione peroxidase 3 gene polymorphisms and risk of differentiated thyroid cancer. (PMID: 19375609) Lin JC … Juo SH (Surgery 2009) 3 22 44 58
  2. Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children. (PMID: 17122425) Voetsch B … Loscalzo J (Stroke 2007) 3 22 44 58
  3. Differential induction of extracellular glutathione peroxidase and nitric oxide synthase 2 in airways of healthy individuals exposed to 100% O(2) or cigarette smoke. (PMID: 10970826) Comhair SA … Erzurum SC (American journal of respiratory cell and molecular biology 2000) 3 4 22 58
  4. The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively. (PMID: 8287691) Chu FF (Cytogenetics and cell genetics 1994) 2 3 22 58
  5. The human plasma glutathione peroxidase-encoding gene: organization, sequence and localization to chromosome 5q32. (PMID: 8056346) Yoshimura S … Moriuchi T (Gene 1994) 3 4 22 58

Products for GPX3 Gene

  • Addgene plasmids for GPX3

Sources for GPX3 Gene

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