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Aliases for GPX3 Gene

Aliases for GPX3 Gene

  • Glutathione Peroxidase 3 2 3 5
  • Extracellular Glutathione Peroxidase 3 4
  • Glutathione Peroxidase 3 (Plasma) 2 3
  • Plasma Glutathione Peroxidase 3 4
  • EC 1.11.1.9 4 63
  • GSHPx-3 3 4
  • GSHPx-P 3 4
  • GPx-3 3 4
  • GPx-P 3 4
  • EC 1.11.1 63
  • GPXP 4

External Ids for GPX3 Gene

Previous GeneCards Identifiers for GPX3 Gene

  • GC05P150468
  • GC05P150429
  • GC05P150430
  • GC05P150381
  • GC05P145545

Summaries for GPX3 Gene

Entrez Gene Summary for GPX3 Gene

  • This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPX3 Gene

GPX3 (Glutathione Peroxidase 3) is a Protein Coding gene. Diseases associated with GPX3 include myocardial infarction and steatitis. Among its related pathways are Cellular Senescence and Folate Metabolism. GO annotations related to this gene include transcription factor binding and selenium binding. An important paralog of this gene is GPX5.

UniProtKB/Swiss-Prot for GPX3 Gene

  • Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.

Gene Wiki entry for GPX3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPX3 Gene

Genomics for GPX3 Gene

Regulatory Elements for GPX3 Gene

Promoters for GPX3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPX3 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPX3 Gene

Chromosome:
5
Start:
151,020,438 bp from pter
End:
151,028,993 bp from pter
Size:
8,556 bases
Orientation:
Plus strand

Genomic View for GPX3 Gene

Genes around GPX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPX3 Gene

Proteins for GPX3 Gene

  • Protein details for GPX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22352-GPX3_HUMAN
    Recommended name:
    Glutathione peroxidase 3
    Protein Accession:
    P22352
    Secondary Accessions:
    • O43787
    • Q86W78
    • Q9NZ74
    • Q9UEL1

    Protein attributes for GPX3 Gene

    Size:
    226 amino acids
    Molecular mass:
    25552 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for GPX3 Gene

neXtProt entry for GPX3 Gene

Proteomics data for GPX3 Gene at MOPED

Post-translational modifications for GPX3 Gene

Antibody Products

  • R&D Systems Antibodies for GPX3 (Glutathione Peroxidase 3/GPX3)

Domains & Families for GPX3 Gene

Protein Domains for GPX3 Gene

Suggested Antigen Peptide Sequences for GPX3 Gene

Graphical View of Domain Structure for InterPro Entry

P22352

UniProtKB/Swiss-Prot:

GPX3_HUMAN :
  • Belongs to the glutathione peroxidase family.
Family:
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX3: view

No data available for Gene Families for GPX3 Gene

Function for GPX3 Gene

Molecular function for GPX3 Gene

GENATLAS Biochemistry:
glutathione peroxidase 3,plasma,expressed in kidney,lung,breast,placenta,catabolic pathway of activated oxygen species,free radical detoxification
UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
UniProtKB/Swiss-Prot Function:
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.

Enzyme Numbers (IUBMB) for GPX3 Gene

Gene Ontology (GO) - Molecular Function for GPX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008430 selenium binding IDA 2491950
genes like me logo Genes that share ontologies with GPX3: view
genes like me logo Genes that share phenotypes with GPX3: view

Animal Models for GPX3 Gene

MGI Knock Outs for GPX3:

Animal Model Products

miRNA for GPX3 Gene

miRTarBase miRNAs that target GPX3

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPX3 Gene

Localization for GPX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPX3 Gene COMPARTMENTS Subcellular localization image for GPX3 gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 3
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
nucleus 2
peroxisome 2
plasma membrane 2
vacuole 2
chloroplast 1

No data available for Gene Ontology (GO) - Cellular Components for GPX3 Gene

Pathways & Interactions for GPX3 Gene

genes like me logo Genes that share pathways with GPX3: view

Pathways by source for GPX3 Gene

Gene Ontology (GO) - Biological Process for GPX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species TAS --
GO:0006979 response to oxidative stress IEA --
GO:0006982 response to lipid hydroperoxide TAS 2491950
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with GPX3: view

No data available for SIGNOR curated interactions for GPX3 Gene

Drugs & Compounds for GPX3 Gene

(21) Drugs for GPX3 Gene - From: Novoseek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target, cofactor 0
Selenocysteine Experimental Pharma 0
Selenium Pharma 166
Hydrogen peroxide Pharma 46

(28) Additional Compounds for GPX3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15(S)-HETE
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoic acid
54845-95-3
15(S)-HPETE
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • 15-Hydroperoxyeicosatetraenoate
  • 15-Hydroperoxyeicosatetraenoic acid
  • 15-Hydroperoxyicosatetraenoate
70981-96-3
5(S)-Hydroperoxyeicosatetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
71774-08-8
5-HETE
  • 5(S)-HETE
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5(S)-Hydroxyeicosatetraenoate
  • 5(S)-Hydroxyeicosatetraenoic acid
70608-72-9
5-Hpete
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-HPETE
74581-83-2
genes like me logo Genes that share compounds with GPX3: view

Transcripts for GPX3 Gene

Unigene Clusters for GPX3 Gene

Glutathione peroxidase 3 (plasma):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPX3 Gene

No ASD Table

Relevant External Links for GPX3 Gene

GeneLoc Exon Structure for
GPX3
ECgene alternative splicing isoforms for
GPX3

Expression for GPX3 Gene

mRNA expression in normal human tissues for GPX3 Gene

mRNA differential expression in normal tissues according to GTEx for GPX3 Gene

This gene is overexpressed in Kidney - Cortex (x9.2), Adipose - Visceral (Omentum) (x4.3), and Adipose - Subcutaneous (x4.1).

Protein differential expression in normal tissues from HIPED for GPX3 Gene

This gene is overexpressed in Vitreous humor (25.7), Kidney (8.2), and Serum (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPX3 Gene



SOURCE GeneReport for Unigene cluster for GPX3 Gene Hs.386793

mRNA Expression by UniProt/SwissProt for GPX3 Gene

P22352-GPX3_HUMAN
Tissue specificity: Secreted in plasma.
genes like me logo Genes that share expression patterns with GPX3: view

Protein tissue co-expression partners for GPX3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GPX3 Gene

Orthologs for GPX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPX3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPX3 35
  • 88.2 (n)
  • 88.05 (a)
GPX3 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPX3 35
  • 90.86 (n)
  • 92.04 (a)
GPX3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpx3 35
  • 87.02 (n)
  • 89.38 (a)
Gpx3 16
Gpx3 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPX3 35
  • 100 (n)
  • 100 (a)
GPX3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpx3 35
  • 87.61 (n)
  • 90.71 (a)
oppossum
(Monodelphis domestica)
Mammalia GPX3 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves GPX3 35
  • 73.93 (n)
  • 71.29 (a)
GPX3 36
  • 66 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gpx3 35
  • 65.32 (n)
  • 67.17 (a)
MGC75694 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.22088 35
zebrafish
(Danio rerio)
Actinopterygii gpx3 35
  • 67.92 (n)
  • 66.67 (a)
gpx3 36
  • 58 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C11E4.1 37
  • 42 (a)
C11E4.2 37
  • 43 (a)
Species with no ortholog for GPX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPX3 Gene

ENSEMBL:
Gene Tree for GPX3 (if available)
TreeFam:
Gene Tree for GPX3 (if available)

Paralogs for GPX3 Gene

Paralogs for GPX3 Gene

(4) SIMAP similar genes for GPX3 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with GPX3: view

Variants for GPX3 Gene

Sequence variations from dbSNP and Humsavar for GPX3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs8177445 - 151,027,454(+) GAGGC(C/T)TTGTC reference, missense
rs4661 -- 151,028,754(+) TGTGA(C/T)AGCAA utr-variant-3-prime
rs11548 -- 151,028,222(+) CATCA(C/T)AGACC utr-variant-3-prime
rs869975 -- 151,026,811(+) CCAGC(A/G)GCACA intron-variant
rs869976 -- 151,026,876(+) CCCAC(A/G)TCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPX3 Gene

Variant ID Type Subtype PubMed ID
nsv526224 CNV Gain 19592680

Variation tolerance for GPX3 Gene

Residual Variation Intolerance Score: 42.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPX3 Gene

HapMap Linkage Disequilibrium report
GPX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPX3 Gene

Disorders for GPX3 Gene

MalaCards: The human disease database

(11) MalaCards diseases for GPX3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myocardial infarction
  • myocardial infarction, protection against
steatitis
toxic encephalopathy
  • neurotoxicity
sulfhemoglobinemia
  • sulfemoglobinemia
diabetes mellitus, insulin-dependent
  • diabetes, type 1
- elite association - COSMIC cancer census association via MalaCards
Search GPX3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPX3

Genetic Association Database (GAD)
GPX3
Human Genome Epidemiology (HuGE) Navigator
GPX3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPX3
genes like me logo Genes that share disorders with GPX3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPX3 Gene

Publications for GPX3 Gene

  1. Expression of plasma glutathione peroxidase in human liver in addition to kidney, heart, lung, and breast in humans and rodents. (PMID: 1339300) Chu F.-F. … Liu X.F. (Blood 1992) 3 4 23 67
  2. Elevated plasma glutathione peroxidase concentration in acute severe asthma: comparison with plasma glutathione peroxidase activity, selenium and malondialdehyde. (PMID: 17558897) Jacobson G.A. … Ng C.H. (Scand. J. Clin. Lab. Invest. 2007) 23 25 26
  3. The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively. (PMID: 8287691) Chu F.F. (Cytogenet. Cell Genet. 1994) 2 3 23
  4. An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer. (PMID: 20043075) Zhang X. … Yang S. (Int. J. Oncol. 2010) 3 23
  5. Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy. (PMID: 20303587) Mistry H.D. … Broughton Pipkin F. (Placenta 2010) 3 23

Products for GPX3 Gene

Sources for GPX3 Gene

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