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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPX3 Gene

protein-coding   GIFtS: 64
GCID: GC05P150381

glutathione peroxidase 3 (plasma)
 Explore 69 diseases affiliated with
GPX3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GPX3    

Aliases
for GPX3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Glutathione Peroxidase 3 (Plasma)1 2     GSHPx-P2 3
Extracellular Glutathione Peroxidase2 3     EC 1.11.1.93 8
Plasma Glutathione Peroxidase2 3     Glutathione Peroxidase 32
GPx-32 3     GPXP3
GPx-P2 3     EC 1.11.18
GSHPx-32 3     

External Ids:    HGNC: 45551   Entrez Gene: 28782   Ensembl: ENSG000002114457   OMIM: 1383215   UniProtKB: P223523   

Export aliases for GPX3 gene to outside databases

Previous GC identifers: GC05P150468 GC05P150997 GC05P150429 GC05P150430 GC05P145545


Summaries
for GPX3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GPX3:
This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen
peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA
codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop
structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather
than as a stop signal. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GPX3_HUMAN, P22352
Function: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid
peroxides and organic hydroperoxide, by glutathione

Gene Wiki entry for GPX3


Genomic Views
for GPX3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_029289.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPX3 gene promoter:
         GR   E2F-5   E2F-1   E2F   Sp1   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GPX3 promoter sequence
   Search SABiosciences Chromatin IP Primers for GPX3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23   Ensembl cytogenetic band:  5q33.1   HGNC cytogenetic band: 5q23

GPX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPX3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P150381:  view genomic region     (about GC identifiers)

Start:
 150,399,999 bp from pter      End:
 150,408,554 bp from pter
Size:
 8,556 bases      Orientation:
 plus strand

Proteins
for GPX3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GPX3_HUMAN, P22352 (See protein sequence)
Recommended Name: Glutathione peroxidase 3 precursor  
Size: 226 amino acids; 25552 Da
Subunit: Homotetramer
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for GPX3:
2R37 (3D)    
Secondary accessions: O43787 Q86W78 Q9NZ74 Q9UEL1

Explore the universe of human proteins at neXtProt for GPX3: NX_P22352

Post-translational modifications:

  • The N-terminus is blocked1
  • View neXtProt modification sites for NX_P22352

    • 4/11 DME Specific Peptides for GPX3 (P22352) (see all 11)
     KGDVNGE  WNFEKFL  ELNALQE  FPCNQFG 

    GPX3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002075.2  
    ENSEMBL proteins: 
     ENSP00000373477   ENSP00000427873   ENSP00000430508   ENSP00000429709   ENSP00000430743  
     ENSP00000429314  

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    Uscn Proteins for GPX3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA1897960
    GO:0005625soluble fraction ----


    GPX3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for GPX3

    Protein Domains /
    Families
    for GPX3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GPX3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR012336 Thioredoxin-like_fold
     IPR000889 Glutathione_peroxidase

    Graphical View of Domain Structure for InterPro Entry P22352

    ProtoNet protein and cluster: P22352

    1 Blocks protein family: IPB000889 Glutathione peroxidase

    UniProtKB/Swiss-Prot: GPX3_HUMAN, P22352
    Similarity: Belongs to the glutathione peroxidase family


    Function
    for GPX3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GPX3_HUMAN, P22352
    Function: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid
    peroxides and organic hydroperoxide, by glutathione
    Catalytic activity: 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O

         Genatlas biochemistry entry for GPX3:
    glutathione peroxidase 3,plasma,expressed in kidney,lung,breast,placenta,catabolic pathway of activated oxygen
    species,free radical detoxification

    Enzyme Numbers (IUBMB): EC 1.11.1.91 2 EC 1.11.12

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GPX3
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate GPX3 (see all 13):
    hsa-miR-2114 hsa-miR-1324 hsa-miR-3155 hsa-miR-650 hsa-miR-484 hsa-miR-873 hsa-miR-298 hsa-miR-378*
    SwitchGear 3'UTR luciferase reporter plasmid: GPX3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GPX3 (see all 7)
    OriGene shRNA RFP: GPX3
    OriGene siRNA: GPX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPX3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for GPX3

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPX3 (see all 3)
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    Sino Biological Human cDNA Clone for GPX3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPX3 

    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004602glutathione peroxidase activity IDA1897960
    GO:0008134transcription factor binding TAS8056346
    GO:0008430selenium binding IDA2491950
    GO:0043295glutathione binding ----


    GPX3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for GPX3: Gpx3tm1Hjco Gpx3tm1Jlos
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Gpx3):
     cardiovascular system  growth/size  hematopoietic system  homeostasis/metabolism  mortality/aging 
     nervous system  renal/urinary system 

    GPX3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GPX3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glutathione metabolism
    		Glutathione metabolism1.00
    		Glutathione metabolism0.70
    		Glutathione metabolism0.92
    		Glutathione metabolism0.44
    2Oxidative Stress
    		Oxidative Stress1.00
    3Selenium Metabolism and Selenoproteins
    		Selenium Metabolism and Selenoproteins1.00
    4Folate Metabolism
    		Folate Metabolism1.00
    5Selenium Pathway
    		Selenium Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for GPX3
        Glutathione metabolism


    1 GeneGo (Thomson Reuters) Pathway for GPX3
        Glutathione metabolism

    5/6 BioSystems Pathways for GPX3 (see all 6) 
        Selenium Metabolism and Selenoproteins
    Folate Metabolism
    Selenium Pathway
    Oxidative Stress
    Glutathione metabolism


    2         Kegg Pathways  (Kegg details for GPX3):
        Glutathione metabolism
    Arachidonic acid metabolism


    GPX3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPX3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/34 Interacting proteins for GPX3 (ENSP000003734774) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALOX15ENSP000002937614STRING: ENSP00000293761
    ALOX15BENSP000003695304STRING: ENSP00000369530
    ALOX5ENSP000003635124STRING: ENSP00000363512
    CYP2C19ENSP000003603724STRING: ENSP00000360372
    CYP2J2ENSP000003602474STRING: ENSP00000360247
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002238response to molecule of fungal origin ----
    GO:0006749glutathione metabolic process ----
    GO:0006982response to lipid hydroperoxide TAS2491950
    GO:0007565female pregnancy ----
    GO:0010033response to organic substance ----


    GPX3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GPX3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GPX3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GPX3

    10/11 HMDB Compounds for GPX3 (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    15(S)-HETE15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid (see all 17)54845-95-3--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--
    5(S)-Hydroperoxyeicosatetraenoic acid5-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid (see all 6)71774-08-8--
    5-HETE5(S)-HETE (see all 14)70608-72-9--
    5-HPETE5(S)-HPETE (see all 7)74581-83-2--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    Oxidized glutathioneGSSG (see all 4)27025-41-8--
    Seleniumselenium (see all 5)7782-49-2--
    Selenocysteine(2R)-2-amino-3-selanylpropanoate (see all 8)3614-08-2--

    1 DrugBank Compound for GPX3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8targetcofactor17578749 17558897

    10/40 Novoseek chemical compound relationships for GPX3 gene (see all 40)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenium 85.4 91 18598587 (3), 11922572 (2), 9363323 (2), 8942409 (2) (see all 48)
    ce-ooh 69.3 1 8503899 (1)
    selenocysteine 67.6 4 19219623 (1), 1339300 (1)
    selenomethionine 66.1 1 8237870 (1)
    linoleic acid hydroperoxide 64.4 2 8239661 (1)
    superoxide 56.6 26 7567818 (2), 10628902 (2), 10749294 (1), 12928050 (1) (see all 22)
    malondialdehyde 55.7 18 15607910 (2), 10749294 (1), 18279752 (1), 17558897 (1) (see all 11)
    vitamin-e 47.7 10 8654156 (1), 12928050 (1), 14967176 (1), 11778848 (1) (see all 7)
    h2o2 46.1 14 8239661 (5), 14671051 (1), 15749805 (1), 8056346 (1) (see all 8)
    thiobarbituric acid 43 3 7567818 (1), 12784046 (1), 12904636 (1)

    Search CenterWatch for drugs/clinical trials and news about GPX3 

    Transcripts
    for GPX3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GPX3 gene: 
    NM_002084.3  

    Unigene Cluster for GPX3:

    Glutathione peroxidase 3 (plasma)
    Hs.386793  [show with all ESTs]
    Unigene Representative Sequence: NM_002084
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000388825(uc021yga.1) ENST00000521722 ENST00000521650 ENST00000519214
    ENST00000517973 ENST00000522916 ENST00000521632 ENST00000521632 ENST00000521632
    ENST00000521632 ENST00000520597 ENST00000520059

    miRNA
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    hsa-miR-2114 hsa-miR-1324 hsa-miR-3155 hsa-miR-650 hsa-miR-484 hsa-miR-873 hsa-miR-298 hsa-miR-378*
    SwitchGear 3'UTR luciferase reporter plasmid: GPX3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF217787.1 AK310242.1 BC013218.1 BC013601.1 BC025956.1 BC035841.1 BC050378.1 BC066949.1 
    D00632.1 X58295.1 

    24/51 DOTS entries (see all 51):

    DT.100887930  DT.95300461  DT.100887902  DT.91778285  DT.95347555  DT.455561  DT.100045685  DT.95329448 
    DT.92038100  DT.100887913  DT.100887937  DT.86997528  DT.100887940  DT.100887943  DT.95179238  DT.120865666 
    DT.91778274  DT.100045691  DT.100887905  DT.100887946  DT.99949810  DT.100034760  DT.91778332  DT.100045684 

    24/1685 AceView cDNA sequences (see all 1685):

    BF839709 BQ638057 CR621477 BU726787 BU185008 CR597434 BQ669727 BF724190 
    BQ640053 AL547202 CA395676 BF725235 AL548380 BF724299 CR594536 BF928273 
    AI300978 CR609961 BQ637912 AL542108 BM663521 BF848761 BG925289 BU687235 

    GeneLoc Exon Structure


    Expression
    for GPX3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGGAGGGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GPX3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeHindgutHindgut Endoderm CellsEndoderm
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    PancreasDorsal Pancreatic BudImmature Beta Progenitor CellsPancreas
    PancreasVentral Pancreatic BudImmature Beta Progenitor CellsPancreas
    Gut TubeHindgutGut Tube
    Gut TubeMidgutGut Tube
    HeartHeart TubeHeart
    HeartLeft AtriumHeart
    HeartRight AtriumHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    HyStem+BMP4-induced 7SMOO32 cells (HyStem+BMP4 inductio...)Adipose

    See GPX3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GPX3

    SOURCE GeneReport for Unigene cluster: Hs.386793

    UniProtKB/Swiss-Prot: GPX3_HUMAN, P22352
    Tissue specificity: Secreted in plasma

        SABiosciences Expression via Pathway-Focused PCR Arrays including GPX3: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Drug Metabolism in human mouse rat

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPX3

    Orthologs
    for GPX3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for GPX3 gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Gpx31 , 5 glutathione peroxidase 31, 5 87.02(n)1
    89.38(a)1    		   11 (32.13 cM)5
    147781  NM_008161.31  NP_032187.21 
     549024535 
    chicken
    (Gallus gallus)    		 Aves GPX31 glutathione peroxidase 3 (plasma) 73.87(n)
    70.42(a)    		   427638  NM_001163232.1  NP_001156704.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.220882 Xenopus laevis transcribed sequence with weak similarity more 78.64(n)    CD252886.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii gpx31 glutathione peroxidase 3 (plasma) 67.92(n)
    66.67(a)    		   798788  NM_001137555.1  NP_001131027.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea C11E4.23 glutathione peroxidase 43(a)
    (best of 2)    		   X(9622964-9624122)   --
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria btuE6
    		 glutathione peroxidase
    		 32(a)
    		 1 → many
    		 Chromosome(1791582-1792133)


    ENSEMBL Gene Tree for GPX3 (if available)
    TreeFam Gene Tree for GPX3 (if available) 

    Paralogs
    for GPX3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GPX3 gene
    GPX62  GPX52  GPX22  GPX72  GPX42  GPX12  GPX82  
    4 SIMAP similar genes for GPX3 using alignment to 8 protein entries:     GPX3_HUMAN (see all proteins):
    GPX5    GPX6    GPX1    GPX2

    GPX3 for paralogs           About GeneDecksing



    Genomic Variants
    for GPX3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/221 NCBI SNPs in GPX3 are shown (see all 221)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs750676691,2
    		F,--150398062(+) AGACAT/CAGAGG 1 -- us2k11Minor allele frequency- C:0.02EA 120
    rs1894011711,2
    		--150398112(+) CTGCAA/CTTGTG 1 -- us2k10--------
    rs20422361,2
    		C,F,A,H,--150398115(+) CACTTG/ATGTGA 1 -- us2k124Minor allele frequency- A:0.17NS EA NA WA 3158
    rs1385089111,2
    		--150398119(+) TGTGTA/GACCCT 1 -- us2k10--------
    rs1930073731,2
    		--150398362(+) AGAACA/GACATG 1 -- us2k10--------
    rs1853222351,2
    		--150398473(+) TCAGGA/GAAATG 1 -- us2k10--------
    rs1174184261,2
    		F,--150398496(+) AAAACG/ATATTG 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1899443121,2
    		--150398572(+) GGCCTC/TTGTGG 1 -- us2k10--------
    rs1415236201,2
    		--150398573(+) GCCTCC/TGTGGT 1 -- us2k10--------
    rs564108401,2
    		C,--150398640(+) AACTTG/AAGAGA 1 -- us2k12Minor allele frequency- A:0.04WA 120

    HapMap Linkage Disequilibrium report for GPX3 (150399999 - 150408554 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for GPX3: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPX3
    DNA2.0 Custom Variant and Variant Library Synthesis for GPX3

    Disorders / Diseases
    for GPX3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GPX3 for disorders           About GeneDecksing

    OMIM gene information: 138321    OMIM disorders: --

    20/69 diseases for GPX3 (see all 69):    About MalaCards
    focal segmental glomerulosclerosis    age related macular degeneration    cor pulmonale    pre-eclampsia
    familial mediterranean fever    acute myocardial infarction    clear cell adenocarcinoma    type 2 diabetes mellitus
    myocardial infarction    ovarian clear cell adenocarcinoma    glucose intolerance    macular degeneration
    diabetes mellitus    keshan disease    acquired immunodeficiency syndrome    esophageal squamous cell carcinoma
    squamous cell carcinoma    coronary heart disease    rheumatoid arthritis    glomerulosclerosis

    1 disease from the University of Copenhagen DISEASES database for GPX3:
    Keshan disease

    10/23 Novoseek disease relationships for GPX3 gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenium deficiency 63.8 2 9417500 (1), 9500709 (1)
    renal failure chronic 29.2 2 14742897 (1), 16937131 (1)
    preeclampsia 25.7 2 12607764 (1), 20303587 (1)
    cataract 15.1 5 9951468 (2), 14644713 (1), 9201431 (1)
    aqueous humor 11.7 2 9201431 (2)
    adenoma 10.3 2 11922572 (1), 14690787 (1)
    diabetes mellitus 0.693 1 12889514 (1)
    stroke 0 3 10446087 (2), 17122425 (1)
    asthma 0 4 17558897 (2)
    renal failure 0 1 7664470 (1)

    Genetic Association Database (GAD): GPX3
    Human Genome Epidemiology (HuGE) Navigator: GPX3 (23 documents)

    Export disorders for GPX3 gene to outside databases

    Publications
    for GPX3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GPX3 gene, integrated from 9 sources (see all 220):
    (articles sorted by number of sources associating them with GPX3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of plasma glutathione peroxidase in human liver in addition to kidney, heart, lung, and breast in humans and rodents. (PubMed id 1339300)1, 2, 9 Chu F.-F.... Liu X.F. (1992)
    2. Characterization and partial amino acid sequence of human plasma glutathione peroxidase. (PubMed id 1897960)1, 2, 9 Esworthy R.S.... Doroshow J.H. (1991)
    3. The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively. (PubMed id 8287691)1, 3, 9 Chu F.F. (1994)
    4. Differential induction of extracellular glutathione peroxidase and nitric oxide synthase 2 in airways of healthy individuals exposed to 100% O(2) or cigarette smoke. (PubMed id 10970826)1, 2, 9 Comhair S.A.A.... Erzurum S.C. (2000)
    5. Primary structure of human plasma glutathione peroxidase deduced from cDNA sequences. (PubMed id 2229017)1, 2, 9 Takahashi K....Koyama J. (1990)
    6. The human plasma glutathione peroxidase-encoding gene: organization, sequence and localization to chromosome 5q32. (PubMed id 8056346)1, 2, 9 Yoshimura S....Moriuchi T. (1994)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus. (PubMed id 12732844)1, 4 Watanabe I....Koga T. (2003)
    9. Purification and characterization of human plasma glutathione peroxidase: a selenoglycoprotein distinct from the known cellular enzyme. (PubMed id 3619451)1, 3 Takahashi K....Cohen H. (1987)
    10. Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma. (PubMed id 19020706)1, 9 Saga Y....Mano H. (2008)

    External Searches for GPX3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GPX3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2878 HGNC: 4555 AceView: GPX3 Ensembl:ENSG00000211445 euGenes: HUgn2878
    ECgene: GPX3 Kegg: 2878 H-InvDB: GPX3

    Other Databases showing GPX3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GPX3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GPX3 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/gpx3/
    Wikipedia http://en.wikipedia.org/wiki/Glutathione_peroxidase

    Intellectual Property
    for GPX3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GPX3 gene:
    Search GeneIP for patents involving GPX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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