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GPX3 Gene

protein-coding   GIFtS: 67
GCID: GC05P150381

Glutathione Peroxidase 3 (Plasma)

  See GPX3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutathione Peroxidase 3 (Plasma)1 2     GSHPx-P2 3
Extracellular Glutathione Peroxidase2 3     EC 1.11.1.93 8
Plasma Glutathione Peroxidase2 3     Glutathione Peroxidase 32
GPx-32 3     GPXP3
GPx-P2 3     EC 1.11.18
GSHPx-32 3     

External Ids:    HGNC: 45551   Entrez Gene: 28782   Ensembl: ENSG000002114457   OMIM: 1383215   UniProtKB: P223523   

Export aliases for GPX3 gene to outside databases

Previous GC identifers: GC05P150468 GC05P150997 GC05P150429 GC05P150430 GC05P145545


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GPX3 Gene:
This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen
peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA
codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop
structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon
rather than as a stop signal. (provided by RefSeq, Jul 2008)

GeneCards Summary for GPX3 Gene:
GPX3 (glutathione peroxidase 3 (plasma)) is a protein-coding gene. Diseases associated with GPX3 include keshan disease. GO annotations related to this gene include transcription factor binding and selenium binding. An important paralog of this gene is GPX6.

UniProtKB/Swiss-Prot: GPX3_HUMAN, P22352
Function: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide,
lipid peroxides and organic hydroperoxide, by glutathione

Gene Wiki entry for GPX3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_029289.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPX3 gene promoter:
         GR   E2F-5   E2F-1   E2F   Sp1   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPX3 promoter sequence
   Search Chromatin IP Primers for GPX3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23   Ensembl cytogenetic band:  5q33.1   HGNC cytogenetic band: 5q23

GPX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPX3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P150381:  view genomic region     (about GC identifiers)

Start:
150,399,999 bp from pter      End:
150,408,554 bp from pter
Size:
8,556 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GPX3_HUMAN, P22352 (See protein sequence)
Recommended Name: Glutathione peroxidase 3 precursor  
Size: 226 amino acids; 25552 Da
Subunit: Homotetramer
1 PDB 3D structure from and Proteopedia for GPX3:
2R37 (3D)    
Secondary accessions: O43787 Q86W78 Q9NZ74 Q9UEL1

Explore the universe of human proteins at neXtProt for GPX3: NX_P22352

Explore proteomics data for GPX3 at MOPED

Post-translational modifications: 

  • The N-terminus is blocked1
  • Modification sites at neXtProt
  • Selected DME Specific Peptides for GPX3 (P22352) (see all 11)
     KGDVNGE  WNFEKFL  ELNALQE  FPCNQFG 


    See GPX3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002075.2  
    ENSEMBL proteins: 
     ENSP00000373477   ENSP00000427873   ENSP00000430508   ENSP00000429709   ENSP00000430743  
     ENSP00000429314  
    Reactome Protein details: P22352

    GPX3 Human Recombinant Protein Products:

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    OriGene Custom Protein Services for GPX3
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    Novus Biologicals GPX3 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GPX3
    Cloud-Clone Corp. Proteins for GPX3

     
    Search eBioscience for Proteins for GPX3 

     
    antibodies-online proteins for GPX3 (8 products) 

     
    antibodies-online peptides for GPX3

    GPX3 Antibody Products:

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    antibodies-online antibodies for GPX3 (49 products) 

    GPX3 Assay Products:

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    Cloud-Clone Corp. ELISAs for GPX3
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    antibodies-online kits for GPX3 (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR000889 Glutathione_peroxidase

    Graphical View of Domain Structure for InterPro Entry P22352

    ProtoNet protein and cluster: P22352

    1 Blocks protein domain: IPB000889 Glutathione peroxidase

    UniProtKB/Swiss-Prot: GPX3_HUMAN, P22352
    Similarity: Belongs to the glutathione peroxidase family


    Find genes that share domains with GPX3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPX3_HUMAN, P22352
    Function: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide,
    lipid peroxides and organic hydroperoxide, by glutathione
    Catalytic activity: 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O

         Genatlas biochemistry entry for GPX3:
    glutathione peroxidase 3,plasma,expressed in kidney,lung,breast,placenta,catabolic pathway of activated oxygen
    species,free radical detoxification

         Enzyme Numbers (IUBMB): EC 1.11.1.91 2 EC 1.11.12

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004602glutathione peroxidase activity IDA1897960
    GO:0008134transcription factor binding TAS8056346
    GO:0008430selenium binding IDA2491950
         
    Find genes that share ontologies with GPX3           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gpx3):
     cardiovascular system  growth/size/body  hematopoietic system  homeostasis/metabolism  mortality/aging 
     nervous system  renal/urinary system 

    Find genes that share phenotypes with GPX3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GPX3: Gpx3tm1Hjco Gpx3tm1Jlos

       genOway: Develop your customized and physiologically relevant rodent model for GPX3

    miRNA
    Products:
        
    miRTarBase miRNAs that target GPX3:
    hsa-mir-92a-3p (MIRT049503)

    Block miRNA regulation of human, mouse, rat GPX3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GPX3 (see all 13):
    hsa-miR-2114 hsa-miR-1324 hsa-miR-3155 hsa-miR-650 hsa-miR-484 hsa-miR-873 hsa-miR-298 hsa-miR-378*
    SwitchGear 3'UTR luciferase reporter plasmidGPX3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat GPX3

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for GPX3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GPX3 (NM_002084)
    Sino Biological Human cDNA Clone for GPX3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPX3
    Addgene plasmids for GPX3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPX3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GPX3_HUMAN, P22352: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA1897960
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with GPX3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GPX3 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.65
    Glutathione metabolism0.45
    Glutathione metabolism0.65
    glutathione redox reactions I0.00
    2Cellular Senescence
    Cellular responses to stress0.81
    3Folate Metabolism
    Folate Metabolism0.54
    4Biological oxidations
    metapathway biotransformation0.42
    5Arachidonic acid metabolism
    Arachidonic acid metabolism0.41


    Find genes that share SuperPaths with GPX3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for GPX3
        Glutathione metabolism

    Selected BioSystems Pathways for GPX3 (see all 7)
        Selenium Metabolism and Selenoproteins
    Oxidative Stress
    Folate Metabolism
    Selenium Pathway
    Glutathione metabolism


    1 Reactome Pathway for GPX3
        Detoxification of Reactive Oxygen Species


    3 Kegg Pathways  (Kegg details for GPX3):
        Glutathione metabolism
    Arachidonic acid metabolism
    Thyroid hormone synthesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GPX3: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GPX3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GPX3 (ENSP000003734774) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALOX15ENSP000002937614STRING: ENSP00000293761
    ALOX15BENSP000003695304STRING: ENSP00000369530
    ALOX5ENSP000003635124STRING: ENSP00000363512
    CYP2C19ENSP000003603724STRING: ENSP00000360372
    CYP2J2ENSP000003602474STRING: ENSP00000360247
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006979response to oxidative stress ----
    GO:0006982response to lipid hydroperoxide TAS2491950
    GO:0042744hydrogen peroxide catabolic process TAS2491950
    GO:0051289protein homotetramerization IDA3693360
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with GPX3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPX3

    Selected HMDB Compounds for GPX3 (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    15(S)-HETE15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid (see all 17)54845-95-3--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--
    5(S)-Hydroperoxyeicosatetraenoic acid5-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid (see all 6)71774-08-8--
    5-HETE5(S)-HETE (see all 14)70608-72-9--
    5-HPETE5(S)-HPETE (see all 7)74581-83-2--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    Oxidized glutathioneGSSG (see all 4)27025-41-8--
    Seleniumselenium (see all 5)7782-49-2--
    Selenocysteine(2R)-2-amino-3-selanylpropanoate (see all 8)3614-08-2--

    1 DrugBank Compound for GPX3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8targetcofactor17578749 17558897

    Selected Novoseek inferred chemical compound relationships for GPX3 gene (see all 40)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenium 85.4 91 18598587 (3), 11922572 (2), 9363323 (2), 8942409 (2) (see all 48)
    ce-ooh 69.3 1 8503899 (1)
    selenocysteine 67.6 4 19219623 (1), 1339300 (1)
    selenomethionine 66.1 1 8237870 (1)
    linoleic acid hydroperoxide 64.4 2 8239661 (1)
    superoxide 56.6 26 7567818 (2), 10628902 (2), 10749294 (1), 12928050 (1) (see all 22)
    malondialdehyde 55.7 18 15607910 (2), 10749294 (1), 18279752 (1), 17558897 (1) (see all 11)
    vitamin-e 47.7 10 8654156 (1), 12928050 (1), 14967176 (1), 11778848 (1) (see all 7)
    h2o2 46.1 14 8239661 (5), 14671051 (1), 15749805 (1), 8056346 (1) (see all 8)
    thiobarbituric acid 43 3 7567818 (1), 12784046 (1), 12904636 (1)



    Find genes that share compounds with GPX3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GPX3 gene: 
    NM_002084.3  

    Unigene Cluster for GPX3:

    Glutathione peroxidase 3 (plasma)
    Hs.386793  [show with all ESTs]
    Unigene Representative Sequence: NM_002084
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000388825(uc021yga.1) ENST00000521722 ENST00000521650 ENST00000519214
    ENST00000517973 ENST00000521632 ENST00000521632 ENST00000521632 ENST00000521632
    ENST00000520597 ENST00000520059
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate GPX3 (see all 13):
    hsa-miR-2114 hsa-miR-1324 hsa-miR-3155 hsa-miR-650 hsa-miR-484 hsa-miR-873 hsa-miR-298 hsa-miR-378*
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    Addgene plasmids for GPX3 
    Primer
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    OriGene qPCR primer pairs and template standards for GPX3
    OriGene qSTAR qPCR primer pairs in human, mouse for GPX3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GPX3
      QuantiTect SYBR Green Assays in human, mouse, rat GPX3
      QuantiFast Probe-based Assays in human, mouse, rat GPX3

    Additional mRNA sequence: 

    AF217787.1 AK310242.1 BC013218.1 BC013601.1 BC025956.1 BC035841.1 BC050378.1 BC066949.1 
    D00632.1 X58295.1 

    Selected DOTS entries (see all 50):

    DT.100887930  DT.95300461  DT.100887902  DT.91778285  DT.95347555  DT.455561  DT.100045685  DT.95329448 
    DT.92038100  DT.100887913  DT.100887937  DT.86997528  DT.100887940  DT.100887943  DT.120865666  DT.91778274 
    DT.100045691  DT.100887946  DT.99949810  DT.100034760  DT.91778332  DT.95179238  DT.100669530  DT.100808777 

    Selected AceView cDNA sequences (see all 1685):

    BQ636614 CA391810 BC035841 BM687633 BQ639113 BG927217 CB216344 CR603874 
    BM999133 CR591749 CA397386 H86375 BM671862 BU687235 BQ640053 CR594135 
    CR590594 AA364628 CR596721 BF725020 CR612826 BQ355606 BF839709 BQ639671 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    GPX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGAGGGGC
    GPX3 Expression
    About this image


    GPX3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Membranous Facial Bones
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Heart Tube
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced E15 cells
    GPX3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPX3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.386793

    UniProtKB/Swiss-Prot: GPX3_HUMAN, P22352
    Tissue specificity: Secreted in plasma

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GPX3: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for GPX3
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    QuantiFast Probe-based Assays in human, mouse, rat GPX3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for GPX3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpx31 , 5 glutathione peroxidase 31, 5 87.02(n)1
    89.38(a)1
      11 (32.13 cM)5
    147781  NM_008161.31  NP_032187.21 
     549024535 
    chicken
    (Gallus gallus)
    Aves GPX31 glutathione peroxidase 3 73.93(n)
    71.29(a)
      427638  NM_001163232.2  NP_001156704.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.220882 Xenopus laevis transcribed sequence with weak similarity more 78.64(n)    CD252886.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gpx31 glutathione peroxidase 3 (plasma) 67.92(n)
    66.67(a)
      798788  NM_001137555.1  NP_001131027.1 


    ENSEMBL Gene Tree for GPX3 (if available)
    TreeFam Gene Tree for GPX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GPX3 gene
    GPX62  GPX52  GPX22  GPX72  GPX42  GPX12  GPX82  
    4 SIMAP similar genes for GPX3 using alignment to 8 protein entries:     GPX3_HUMAN (see all proteins):
    GPX5    GPX6    GPX1    GPX2

    Find genes that share paralogs with GPX3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GPX3 (see all 274)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs750676691,2
    C,F--150398062(+) AGACAT/CAGAGG 1 -- us2k11Minor allele frequency- C:0.02EA 120
    rs1894011711,2
    --150398112(+) CTGCAA/CTTGTG 1 -- us2k10--------
    rs20422361,2
    C,F,A,H--150398115(+) CACTTG/ATGTGA 1 -- us2k124Minor allele frequency- A:0.17NS EA NA WA 3158
    rs1385089111,2
    C--150398119(+) TGTGTA/GACCCT 1 -- us2k10--------
    rs1930073731,2
    --150398362(+) AGAACA/GACATG 1 -- us2k10--------
    rs1853222351,2
    --150398473(+) TCAGGA/GAAATG 1 -- us2k10--------
    rs1174184261,2
    F--150398496(+) AAAACG/ATATTG 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1899443121,2
    --150398572(+) GGCCTC/TTGTGG 1 -- us2k10--------
    rs1415236201,2
    C--150398573(+) GCCTCC/TGTGGT 1 -- us2k10--------
    rs564108401,2
    C--150398640(+) AACTTG/AAGAGA 1 -- us2k12Minor allele frequency- A:0.04WA 120

    HapMap Linkage Disequilibrium report for GPX3 (150399999 - 150408554 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GPX3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv526224CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPX3
    DNA2.0 Custom Variant and Variant Library Synthesis for GPX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138321    OMIM disorders: --

    1 disease for GPX3:    
    About MalaCards
    keshan disease

    1 disease from the University of Copenhagen DISEASES database for GPX3:
    Keshan disease

    Find genes that share disorders with GPX3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for GPX3 gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenium deficiency 63.8 2 9417500 (1), 9500709 (1)
    renal failure chronic 29.2 2 14742897 (1), 16937131 (1)
    preeclampsia 25.7 2 12607764 (1), 20303587 (1)
    cataract 15.1 5 9951468 (2), 14644713 (1), 9201431 (1)
    aqueous humor 11.7 2 9201431 (2)
    adenoma 10.3 2 11922572 (1), 14690787 (1)
    diabetes mellitus 0.693 1 12889514 (1)
    stroke 0 3 10446087 (2), 17122425 (1)
    asthma 0 4 17558897 (2)
    renal failure 0 1 7664470 (1)

    Genetic Association Database (GAD): GPX3
    Human Genome Epidemiology (HuGE) Navigator: GPX3 (23 documents)

    Export disorders for GPX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPX3 gene, integrated from 10 sources (see all 228):
    (articles sorted by number of sources associating them with GPX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of plasma glutathione peroxidase in human liver in addition to kidney, heart, lung, and breast in humans and rodents. (PubMed id 1339300)1, 2, 9 Chu F.-F.... Liu X.F. (Blood 1992)
    2. Characterization and partial amino acid sequence of human plasma glutathione peroxidase. (PubMed id 1897960)1, 2, 9 Esworthy R.S.... Doroshow J.H. (Arch. Biochem. Biophys. 1991)
    3. The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively. (PubMed id 8287691)1, 3, 9 Chu F.F. (Cytogenet. Cell Genet. 1994)
    4. Glutathione peroxidase 3 gene polymorphisms and risk of differentiated thyroid cancer. (PubMed id 19375609)1, 4, 9 Lin J.C....Juo S.H. (Surgery 2009)
    5. Differential induction of extracellular glutathione peroxidase and nitric oxide synthase 2 in airways of healthy individuals exposed to 100% O(2) or cigarette smoke. (PubMed id 10970826)1, 2, 9 Comhair S.A.A.... Erzurum S.C. (Am. J. Respir. Cell Mol. Biol. 2000)
    6. Primary structure of human plasma glutathione peroxidase deduced from cDNA sequences. (PubMed id 2229017)1, 2, 9 Takahashi K....Koyama J. (J. Biochem. 1990)
    7. Simultaneous genotyping of 11 non-synonymous SNPs in the 4 glutathione peroxidase genes using the multiplex single base extension method. (PubMed id 19161995)1, 4, 9 Iida R....Yasuda T. ( international journal of clinical chemistry 2009)
    8. Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma. (PubMed id 18483336)1, 4, 9 Peters U....Foster C.B. (amp 2008)
    9. Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children. (PubMed id 17122425)1, 4, 9 Voetsch B....Loscalzo J. ( a journal of cerebral circulation 2007)
    10. The human plasma glutathione peroxidase-encoding gene: organization, sequence and localization to chromosome 5q32. (PubMed id 8056346)1, 2, 9 Yoshimura S....Moriuchi T. (Gene 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2878 HGNC: 4555 AceView: GPX3 Ensembl:ENSG00000211445 euGenes: HUgn2878
    ECgene: GPX3 Kegg: 2878 H-InvDB: GPX3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GPX3 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/gpx3/
    Wikipedia http://en.wikipedia.org/wiki/Glutathione_peroxidase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GPX3 gene:
    Search GeneIP for patents involving GPX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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