Aliases for GPX3 Gene
External Ids for GPX3 Gene
Previous GeneCards Identifiers for GPX3 Gene
This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]
GeneCards Summary for GPX3 Gene
GPX3 (Glutathione Peroxidase 3) is a Protein Coding gene. Diseases associated with GPX3 include steatitis and sulfhemoglobinemia. Among its related pathways are Cellular Senescence and Insulin secretion. GO annotations related to this gene include transcription factor binding and selenium binding. An important paralog of this gene is GPX4.
UniProtKB/Swiss-Prot for GPX3 Gene
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione