Aliases for GPX2 Gene
External Ids for GPX2 Gene
Previous GeneCards Identifiers for GPX2 Gene
This gene is a member of the glutathione peroxidase family and encodes a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. The protein encoded by this locus contains a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]
GeneCards Summary for GPX2 Gene
GPX2 (Glutathione Peroxidase 2) is a Protein Coding gene. Diseases associated with GPX2 include steatitis and toxic encephalopathy. Among its related pathways are Linoleic acid metabolism and Glutathione metabolism. GO annotations related to this gene include electron carrier activity and glutathione peroxidase activity. An important paralog of this gene is GPX5.
UniProtKB/Swiss-Prot for GPX2 Gene
Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.