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Aliases for GPX2 Gene

Aliases for GPX2 Gene

  • Glutathione Peroxidase 2 2 3 5
  • Glutathione Peroxidase 2 (Gastrointestinal) 2 3
  • Glutathione Peroxidase-Related Protein 2 3 4
  • Gastrointestinal Glutathione Peroxidase 3 4
  • EC 1.11.1.9 4 61
  • GSHPX-GI 3 4
  • GSHPx-2 3 4
  • GPRP-2 3 4
  • GPx-GI 3 4
  • GPx-2 3 4
  • Glutathione Peroxidase-Gastrointestinal 4
  • EC 1.11.1 61
  • GI-GPx 3
  • GPRP 3

External Ids for GPX2 Gene

Previous GeneCards Identifiers for GPX2 Gene

  • GC14M062733
  • GC14M059199
  • GC14M063395
  • GC14M064475
  • GC14M065405
  • GC14M045575

Summaries for GPX2 Gene

Entrez Gene Summary for GPX2 Gene

  • The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]

GeneCards Summary for GPX2 Gene

GPX2 (Glutathione Peroxidase 2) is a Protein Coding gene. Diseases associated with GPX2 include Colorectal Cancer. Among its related pathways are Cytochrome P450 - arranged by substrate type and Arachidonic acid metabolism. GO annotations related to this gene include electron carrier activity and glutathione peroxidase activity. An important paralog of this gene is GPX1.

UniProtKB/Swiss-Prot for GPX2 Gene

  • Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.

Gene Wiki entry for GPX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPX2 Gene

Genomics for GPX2 Gene

Regulatory Elements for GPX2 Gene

Enhancers for GPX2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F064917 0.7 Ensembl ENCODE 11.8 +24.4 24404 2.6 SOX13 ZNF316 TEAD1 CEBPA CEBPG EMSY MAFK TEAD3 CHURC1 GPX2 SPTB CHURC1-FNTB GC14P064933
GH14F064915 0.2 ENCODE 11.6 +26.9 26920 0.1 CBX3 ATF3 CEBPB ZBTB33 TRIM24 GPX2 CHURC1 CHURC1-FNTB GC14P064933
GH14F064913 1 ENCODE 11.6 +28.1 28123 2.0 ATF1 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 BRCA1 YY1 CHURC1 GPX2 SPTB LOC100506321 CHURC1-FNTB GC14P064933
GH14F064976 0.2 ENCODE 10.9 -34.3 -34336 0.9 JUNB TCF7 ZBTB33 ETV6 RFX5 RAB15 GPX2 FNTB
GH14F065001 0.2 ENCODE 10.9 -59.0 -58953 0.2 JUNB GPX2 CHURC1 CHURC1-FNTB RPPH1-2P ENSG00000272158 GC14P064987
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GPX2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPX2 Gene

Chromosome:
14
Start:
64,939,152 bp from pter
End:
64,942,905 bp from pter
Size:
3,754 bases
Orientation:
Minus strand

Genomic View for GPX2 Gene

Genes around GPX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPX2 Gene

Proteins for GPX2 Gene

  • Protein details for GPX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18283-GPX2_HUMAN
    Recommended name:
    Glutathione peroxidase 2
    Protein Accession:
    P18283
    Secondary Accessions:
    • Q6PJ52
    • Q8WWI7
    • Q9NRP9

    Protein attributes for GPX2 Gene

    Size:
    190 amino acids
    Molecular mass:
    21954 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for GPX2 Gene

neXtProt entry for GPX2 Gene

Selected DME Specific Peptides for GPX2 Gene

Post-translational modifications for GPX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPX2 Gene

Antibody Products

  • R&D Systems Antibodies for GPX2 (Glutathione Peroxidase 2/GPX2)

Domains & Families for GPX2 Gene

Gene Families for GPX2 Gene

Protein Domains for GPX2 Gene

Suggested Antigen Peptide Sequences for GPX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18283

UniProtKB/Swiss-Prot:

GPX2_HUMAN :
  • Belongs to the glutathione peroxidase family.
Family:
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX2: view

Function for GPX2 Gene

Molecular function for GPX2 Gene

GENATLAS Biochemistry:
glutathione peroxidase 2,expressed in liver and gastrointestinal tissues,catabolic pathway of activated oxygen species,free radical detoxification
UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
UniProtKB/Swiss-Prot Function:
Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.

Enzyme Numbers (IUBMB) for GPX2 Gene

Gene Ontology (GO) - Molecular Function for GPX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity IEA --
GO:0004602 glutathione peroxidase activity IEA,TAS --
GO:0009055 electron carrier activity TAS 8428933
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with GPX2: view
genes like me logo Genes that share phenotypes with GPX2: view

Animal Models for GPX2 Gene

MGI Knock Outs for GPX2:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPX2

miRNA for GPX2 Gene

miRTarBase miRNAs that target GPX2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPX2

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPX2 Gene

Localization for GPX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX2 Gene

Cytoplasm. Note=Mainly cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPX2 Gene COMPARTMENTS Subcellular localization image for GPX2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 4
mitochondrion 3
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
peroxisome 2
plasma membrane 2
vacuole 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for GPX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,TAS 8428933
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with GPX2: view

Pathways & Interactions for GPX2 Gene

genes like me logo Genes that share pathways with GPX2: view

Gene Ontology (GO) - Biological Process for GPX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species TAS --
GO:0006979 response to oxidative stress IEA --
GO:0055114 oxidation-reduction process IEA --
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with GPX2: view

No data available for SIGNOR curated interactions for GPX2 Gene

Drugs & Compounds for GPX2 Gene

(6) Drugs for GPX2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target, cofactor 0
Water Approved Pharma 0
Selenocysteine Experimental Pharma 0
Selenium Pharma 175
Hydrogen peroxide Pharma 55

(12) Additional Compounds for GPX2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15(S)-HETE
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoic acid
54845-95-3
15(S)-HPETE
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • 15-Hydroperoxyeicosatetraenoate
  • 15-Hydroperoxyeicosatetraenoic acid
  • 15-Hydroperoxyicosatetraenoate
70981-96-3
5(S)-Hydroperoxyeicosatetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
71774-08-8
5-HETE
  • 5(S)-HETE
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5(S)-Hydroxyeicosatetraenoate
  • 5(S)-Hydroxyeicosatetraenoic acid
70608-72-9
5-Hpete
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-HPETE
74581-83-2
genes like me logo Genes that share compounds with GPX2: view

Transcripts for GPX2 Gene

Unigene Clusters for GPX2 Gene

Glutathione peroxidase 2 (gastrointestinal):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPX2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPX2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1: -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for GPX2 Gene

GeneLoc Exon Structure for
GPX2
ECgene alternative splicing isoforms for
GPX2

Expression for GPX2 Gene

mRNA expression in normal human tissues for GPX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPX2 Gene

This gene is overexpressed in Liver (x17.2), Colon - Transverse (x8.7), Bladder (x7.0), and Stomach (x5.0).

Protein differential expression in normal tissues from HIPED for GPX2 Gene

This gene is overexpressed in Salivary gland (14.0), Stomach (11.7), Cardia (7.6), and Rectum (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GPX2 Gene



Protein tissue co-expression partners for GPX2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPX2 Gene:

GPX2

SOURCE GeneReport for Unigene cluster for GPX2 Gene:

Hs.2704

mRNA Expression by UniProt/SwissProt for GPX2 Gene:

P18283-GPX2_HUMAN
Tissue specificity: Mostly in liver and gastrointestinal tract, not found in heart or kidney.
genes like me logo Genes that share expression patterns with GPX2: view

Primer Products

Orthologs for GPX2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPX2 34 35
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia GPX2 34 35
  • 95.61 (n)
cow
(Bos Taurus)
Mammalia GPX2 34 35
  • 92.98 (n)
oppossum
(Monodelphis domestica)
Mammalia GPX2 35
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpx2 34
  • 90 (n)
mouse
(Mus musculus)
Mammalia Gpx2 34 16 35
  • 89.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GPX2 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPX2 34 35
  • 74.37 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpx2 34
  • 68.96 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7237 34
zebrafish
(Danio rerio)
Actinopterygii gpx1b 35
  • 64 (a)
ManyToMany
gpx1 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8637 34
Species where no ortholog for GPX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPX2 Gene

ENSEMBL:
Gene Tree for GPX2 (if available)
TreeFam:
Gene Tree for GPX2 (if available)

Paralogs for GPX2 Gene

Paralogs for GPX2 Gene

(6) SIMAP similar genes for GPX2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for GPX2 Gene

genes like me logo Genes that share paralogs with GPX2: view

Variants for GPX2 Gene

Sequence variations from dbSNP and Humsavar for GPX2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10145845 -- 64,941,255(+) TAGAA(A/G)CAAGG intron-variant
rs112035063 -- 64,943,483(+) CCATC(C/T)CCTAT intron-variant, upstream-variant-2KB
rs113991216 -- 64,941,717(+) TTGTA(C/T)GTTAA intron-variant
rs11623705 -- 64,939,004(+) CCTTG(G/T)CCAGC intron-variant, downstream-variant-500B
rs11628603 -- 64,942,968(+) GCAAC(C/T)TGGGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPX2 Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV deletion 23290073

Variation tolerance for GPX2 Gene

Residual Variation Intolerance Score: 56.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPX2 Gene

Disorders for GPX2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPX2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search GPX2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPX2

Genetic Association Database (GAD)
GPX2
Human Genome Epidemiology (HuGE) Navigator
GPX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPX2
genes like me logo Genes that share disorders with GPX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPX2 Gene

Publications for GPX2 Gene

  1. Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI. (PMID: 8428933) Chu F.-F. … Esworthy R.S. (J. Biol. Chem. 1993) 2 3 4 22 64
  2. Simultaneous genotyping of 11 non-synonymous SNPs in the 4 glutathione peroxidase genes using the multiplex single base extension method. (PMID: 19161995) Iida R. … Yasuda T. (Clin. Chim. Acta 2009) 3 22 46 64
  3. Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma. (PMID: 18483336) Peters U. … Foster C.B. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 22 46 64
  4. A population-based association study of SNPs of GSTP1, MnSOD, GPX2 and Barrett's esophagus and esophageal adenocarcinoma. (PMID: 17277236) Murphy S.J. … Murray L.J. (Carcinogenesis 2007) 3 22 46 64
  5. Structural organization of the human gastrointestinal glutathione peroxidase (GPX2) promoter and 3'-nontranscribed region: transcriptional response to exogenous redox agents. (PMID: 10806356) Kelner M.J. … Lanham K.A. (Gene 2000) 3 4 22 64

Products for GPX2 Gene

Sources for GPX2 Gene

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