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Aliases for GPX2 Gene

Aliases for GPX2 Gene

  • Glutathione Peroxidase 2 2 3 5
  • Glutathione Peroxidase 2 (Gastrointestinal) 2 3
  • Glutathione Peroxidase-Related Protein 2 3 4
  • Gastrointestinal Glutathione Peroxidase 3 4
  • EC 1.11.1.9 4 63
  • GSHPX-GI 3 4
  • GSHPx-2 3 4
  • GPRP-2 3 4
  • GPx-GI 3 4
  • GPx-2 3 4
  • Glutathione Peroxidase-Gastrointestinal 4
  • EC 1.11.1 63
  • GI-GPx 3
  • GPRP 3

External Ids for GPX2 Gene

Previous GeneCards Identifiers for GPX2 Gene

  • GC14M062733
  • GC14M059199
  • GC14M063395
  • GC14M064475
  • GC14M065405
  • GC14M045575

Summaries for GPX2 Gene

Entrez Gene Summary for GPX2 Gene

  • This gene is a member of the glutathione peroxidase family and encodes a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. The protein encoded by this locus contains a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

GeneCards Summary for GPX2 Gene

GPX2 (Glutathione Peroxidase 2) is a Protein Coding gene. Diseases associated with GPX2 include steatitis and toxic encephalopathy. Among its related pathways are Linoleic acid metabolism and Glutathione metabolism. GO annotations related to this gene include electron carrier activity and glutathione peroxidase activity. An important paralog of this gene is GPX5.

UniProtKB/Swiss-Prot for GPX2 Gene

  • Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.

Gene Wiki entry for GPX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPX2 Gene

Genomics for GPX2 Gene

Regulatory Elements for GPX2 Gene

Enhancers for GPX2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPX2 on UCSC Golden Path with GeneCards custom track

Promoters for GPX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPX2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPX2 Gene

Chromosome:
14
Start:
64,939,152 bp from pter
End:
64,942,905 bp from pter
Size:
3,754 bases
Orientation:
Minus strand

Genomic View for GPX2 Gene

Genes around GPX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPX2 Gene

Proteins for GPX2 Gene

  • Protein details for GPX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18283-GPX2_HUMAN
    Recommended name:
    Glutathione peroxidase 2
    Protein Accession:
    P18283
    Secondary Accessions:
    • Q6PJ52
    • Q8WWI7
    • Q9NRP9

    Protein attributes for GPX2 Gene

    Size:
    190 amino acids
    Molecular mass:
    21954 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for GPX2 Gene

neXtProt entry for GPX2 Gene

Proteomics data for GPX2 Gene at MOPED

Selected DME Specific Peptides for GPX2 Gene

Post-translational modifications for GPX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPX2 Gene

Antibody Products

  • R&D Systems Antibodies for GPX2 (Glutathione Peroxidase 2/GPX2)

Domains & Families for GPX2 Gene

Protein Domains for GPX2 Gene

Suggested Antigen Peptide Sequences for GPX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18283

UniProtKB/Swiss-Prot:

GPX2_HUMAN :
  • Belongs to the glutathione peroxidase family.
Family:
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX2: view

No data available for Gene Families for GPX2 Gene

Function for GPX2 Gene

Molecular function for GPX2 Gene

GENATLAS Biochemistry:
glutathione peroxidase 2,expressed in liver and gastrointestinal tissues,catabolic pathway of activated oxygen species,free radical detoxification
UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
UniProtKB/Swiss-Prot Function:
Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.

Enzyme Numbers (IUBMB) for GPX2 Gene

Gene Ontology (GO) - Molecular Function for GPX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004602 glutathione peroxidase activity IEA,TAS --
genes like me logo Genes that share ontologies with GPX2: view
genes like me logo Genes that share phenotypes with GPX2: view

Animal Models for GPX2 Gene

MGI Knock Outs for GPX2:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPX2

miRNA for GPX2 Gene

miRTarBase miRNAs that target GPX2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPX2 Gene

Localization for GPX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX2 Gene

Cytoplasm. Note=Mainly cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPX2 Gene COMPARTMENTS Subcellular localization image for GPX2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 4
mitochondrion 3
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
peroxisome 2
plasma membrane 2
vacuole 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for GPX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 8428933
genes like me logo Genes that share ontologies with GPX2: view

Pathways & Interactions for GPX2 Gene

genes like me logo Genes that share pathways with GPX2: view

Interacting Proteins for GPX2 Gene

Gene Ontology (GO) - Biological Process for GPX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006979 response to oxidative stress IEA --
GO:0055114 oxidation-reduction process IEA --
GO:0098869 cellular oxidant detoxification IEA,TAS 8428933
genes like me logo Genes that share ontologies with GPX2: view

No data available for SIGNOR curated interactions for GPX2 Gene

Drugs & Compounds for GPX2 Gene

(4) Drugs for GPX2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target, cofactor 0
Selenocysteine Experimental Pharma 0
Selenium Pharma 168
Hydrogen peroxide Pharma 47

(14) Additional Compounds for GPX2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15(S)-HETE
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoic acid
54845-95-3
15(S)-HPETE
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • 15-Hydroperoxyeicosatetraenoate
  • 15-Hydroperoxyeicosatetraenoic acid
  • 15-Hydroperoxyicosatetraenoate
70981-96-3
5(S)-Hydroperoxyeicosatetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
71774-08-8
5-HETE
  • 5(S)-HETE
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5(S)-Hydroxyeicosatetraenoate
  • 5(S)-Hydroxyeicosatetraenoic acid
70608-72-9
5-Hpete
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-HPETE
74581-83-2
genes like me logo Genes that share compounds with GPX2: view

Transcripts for GPX2 Gene

Unigene Clusters for GPX2 Gene

Glutathione peroxidase 2 (gastrointestinal):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPX2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1: -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for GPX2 Gene

GeneLoc Exon Structure for
GPX2
ECgene alternative splicing isoforms for
GPX2

Expression for GPX2 Gene

mRNA expression in normal human tissues for GPX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPX2 Gene

This gene is overexpressed in Liver (x17.2), Colon - Transverse (x8.7), Bladder (x7.0), and Stomach (x5.0).

Protein differential expression in normal tissues from HIPED for GPX2 Gene

This gene is overexpressed in Salivary gland (14.0), Stomach (11.7), Cardia (7.6), and Rectum (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPX2 Gene



SOURCE GeneReport for Unigene cluster for GPX2 Gene Hs.2704

mRNA Expression by UniProt/SwissProt for GPX2 Gene

P18283-GPX2_HUMAN
Tissue specificity: Mostly in liver and gastrointestinal tract, not found in heart or kidney.
genes like me logo Genes that share expression patterns with GPX2: view

Protein tissue co-expression partners for GPX2 Gene

- Elite partner

Orthologs for GPX2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPX2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPX2 35
  • 92.98 (n)
  • 96.84 (a)
GPX2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPX2 35
  • 95.61 (n)
  • 97.89 (a)
GPX2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpx2 35
  • 89.65 (n)
  • 93.68 (a)
Gpx2 16
Gpx2 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPX2 35
  • 99.82 (n)
  • 100 (a)
GPX2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpx2 35
  • 90 (n)
  • 94.21 (a)
oppossum
(Monodelphis domestica)
Mammalia GPX2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPX2 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPX2 35
  • 74.37 (n)
  • 75.27 (a)
GPX2 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpx2 35
  • 68.96 (n)
  • 74.07 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7237 35
zebrafish
(Danio rerio)
Actinopterygii gpx1 35
gpx1b 36
  • 64 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8637 35
Species with no ortholog for GPX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPX2 Gene

ENSEMBL:
Gene Tree for GPX2 (if available)
TreeFam:
Gene Tree for GPX2 (if available)

Paralogs for GPX2 Gene

Paralogs for GPX2 Gene

(6) SIMAP similar genes for GPX2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GPX2: view

Variants for GPX2 Gene

Sequence variations from dbSNP and Humsavar for GPX2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_003615 -
VAR_003616 -
VAR_020916 -
VAR_020917 -

Structural Variations from Database of Genomic Variants (DGV) for GPX2 Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV Deletion 23290073

Variation tolerance for GPX2 Gene

Residual Variation Intolerance Score: 56.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPX2 Gene

HapMap Linkage Disequilibrium report
GPX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPX2 Gene

Disorders for GPX2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for GPX2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
steatitis
toxic encephalopathy
  • neurotoxicity
sulfhemoglobinemia
  • sulfemoglobinemia
vitreous syneresis
  • vitreous degeneration
swayback
  • swayback of sheep
- elite association - COSMIC cancer census association via MalaCards
Search GPX2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPX2

Genetic Association Database (GAD)
GPX2
Human Genome Epidemiology (HuGE) Navigator
GPX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPX2
genes like me logo Genes that share disorders with GPX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPX2 Gene

Publications for GPX2 Gene

  1. Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI. (PMID: 8428933) Chu F.-F. … Esworthy R.S. (J. Biol. Chem. 1993) 2 3 4 23 67
  2. Simultaneous genotyping of 11 non-synonymous SNPs in the 4 glutathione peroxidase genes using the multiplex single base extension method. (PMID: 19161995) Iida R. … Yasuda T. (Clin. Chim. Acta 2009) 3 23
  3. GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells. (PMID: 18479189) Banning A. … Brigelius-FlohAc R. (Antioxid. Redox Signal. 2008) 3 23
  4. Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma. (PMID: 18483336) Peters U. … Foster C.B. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 23
  5. Glutathione Peroxidase 2 Inhibits Cyclooxygenase-2-Mediated Migration and Invasion of HT-29 Adenocarcinoma Cells but Supports Their Growth as Tumors in Nude Mice. (PMID: 19047153) Banning A. … Brigelius-FlohAc R. (Cancer Res. 2008) 3 23

Products for GPX2 Gene

Sources for GPX2 Gene

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