Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPX1 Gene

protein-coding   GIFtS: 70
GCID: GC03M049369

Glutathione Peroxidase 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Glutathione Peroxidase 11 2     EC 1.11.1.93 8
Cellular Glutathione Peroxidase2 3     GPXD2
GPx-12 3     GSHPX12
GSHPx-12 3     EC 1.11.18

External Ids:    HGNC: 45531   Entrez Gene: 28762   Ensembl: ENSG000002332767   OMIM: 1383205   UniProtKB: P072033   

Export aliases for GPX1 gene to outside databases

Previous GC identifers: GC03P048736 GC03P048542 GC03M049249 GC03M049353


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GPX1 Gene:
This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the
detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein
is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active
site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon.
In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which
includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA
repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants
encoding distinct isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for GPX1 Gene: 
GPX1 (glutathione peroxidase 1) is a protein-coding gene. Diseases associated with GPX1 include keshan disease, and stress cardiomyopathy, and among its related super-pathways are Glutathione metabolism and Arachidonic acid metabolism. GO annotations related to this gene include SH3 domain binding and glutathione peroxidase activity. An important paralog of this gene is GPX6.

UniProtKB/Swiss-Prot: GPX1_HUMAN, P07203
Function: Protects the hemoglobin in erythrocytes from oxidative breakdown

Gene Wiki entry for GPX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPX1 gene promoter:
         PPAR-gamma1   AP-1   p53   ATF-2   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GPX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

GPX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPX1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M049369:  view genomic region     (about GC identifiers)

Start:
49,394,609 bp from pter      End:
49,396,033 bp from pter
Size:
1,425 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GPX1_HUMAN, P07203 (See protein sequence)
Recommended Name: Glutathione peroxidase 1  
Size: 203 amino acids; 22088 Da
Subunit: Homotetramer. Interacts with MIEN1
Subcellular location: Cytoplasm
1 PDB 3D structure from and Proteopedia for GPX1:
2F8A (3D)    
Secondary accessions: E9PAS1 Q7Z5H1 Q9BW12
Alternative splicing: 2 isoforms:  P07203-1   P07203-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for GPX1: NX_P07203

Explore proteomics data for GPX1 at MOPED 

Post-translational modifications:

  • UniProtKB: During periods of oxidative stress, Sec-49 may react with a superoxide radical, irreversibly lose hydroselenide
    and be converted to dehydroalanine (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P07203

  • 4/18 DME Specific Peptides for GPX1 (P07203) (see all 18)
     RRYSRRF  WNFEKFL  PVCRNDV  FPCNQFG 

    GPX1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GPX1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000572.2  NP_958799.1  

    ENSEMBL proteins: 
     ENSP00000407375   ENSP00000391316  
    Reactome Protein details: P07203
    Human Recombinant Protein Products for GPX1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for GPX1
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GPX1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for GPX1
    GenScript Custom Purified and Recombinant Proteins Services for GPX1
    Novus Biologicals GPX1 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for GPX1
    Cloud-Clone Corp. Proteins for GPX1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA10833429
    GO:0005739mitochondrion IDA10833429
    GO:0005829cytosol TAS--

    GPX1 for ontologies           About GeneDecksing



    GPX1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of GPX1
    R&D Systems Antibodies for GPX1 (Glutathione Peroxidase 1/GPX1)
    Cell Signaling Technology (CST) Antibodies for GPX1 
    OriGene Antibodies for GPX1
    OriGene Custom Antibody Services for GPX1
    GenScript Custom Superior Antibodies Services for GPX1
    Novus Biologicals GPX1 Antibodies
    Abcam antibodies for GPX1
    Cloud-Clone Corp. Antibodies for GPX1 
    ThermoFisher Antibody for GPX1
    LSBio Antibodies in human, mouse, rat for GPX1 

    Assay Products for GPX1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GPX1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GPX1
    Enzo Life Sciences assays for GPX1
    Cloud-Clone Corp. ELISAs for GPX1 
    Cloud-Clone Corp. CLIAs for GPX1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR000889 Glutathione_peroxidase

    Graphical View of Domain Structure for InterPro Entry P07203

    ProtoNet protein and cluster: P07203

    1 Blocks protein domain: IPB000889 Glutathione peroxidase

    UniProtKB/Swiss-Prot: GPX1_HUMAN, P07203
    Similarity: Belongs to the glutathione peroxidase family


    GPX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPX1_HUMAN, P07203
    Function: Protects the hemoglobin in erythrocytes from oxidative breakdown
    Catalytic activity: 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O

         Genatlas biochemistry entry for GPX1:
    glutathione peroxidase 1,selenium dependent,cellular,catabolic pathway of activated oxygen species,free radical
    detoxification

         Enzyme Numbers (IUBMB): EC 1.11.1.91 2 EC 1.11.12

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004602glutathione peroxidase activity TAS--
    GO:0004866endopeptidase inhibitor activity IDA12751788
    GO:0005515protein binding ----
    GO:0017124SH3 domain binding IPI12893824
         
    GPX1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GPX1:
     Increased viability after born 

         12 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Gpx1):
     cellular  digestive/alimentary  endocrine/exocrine gland  growth/size  hearing/vestibular/ear 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  nervous system 
     no phenotypic analysis  vision/eye 

    GPX1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GPX1: Gpx1tm1Kola Gpx1tm1Ysh Gpx1tm1Mgr

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GPX1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GPX1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GPX1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GPX1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GPX1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GPX1
    SwitchGear 3'UTR luciferase reporter plasmidGPX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GPX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPX1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GPX1
    Sirion Biotech Customized adenovirus for overexpression of GPX1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GPX1 (see all 9)
    OriGene ORF clones in mouse, rat for GPX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GPX1 (NM_201397)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPX1
    Sirion Biotech Customized lentivirus for stable overexpression of GPX1 
                         Customized lentivirus expression plasmids for stable overexpression of GPX1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GPX1
    Search LifeMap BioReagents cell lines for GPX1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPX1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GPX1 About   (see all 18)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.92
    Glutathione metabolism0.45
    Glutathione metabolism0.67
    2Arachidonic acid metabolism
    Arachidonic acid metabolism0.44
    HETE and HPETE biosynthesis and metabolism0.35
    Arachidonic acid metabolism0.44
    3Synthesis of 15-eicosatetraenoic acid derivatives
    Synthesis of 15-eicosatetraenoic acid derivatives0.50
    Synthesis of 5-eicosatetraenoic acids0.33
    Synthesis of 12-eicosatetraenoic acid derivatives0.50
    4Purine metabolism
    Purine metabolism0.42
    Purine catabolism0.30
    Metabolism of nucleotides0.42
    5Doxorubicin Pathway, Pharmacokinetics
    Doxorubicin Pathway (Cancer Cell), Pharmacodynamics0.43
    Doxorubicin Pathway, Pharmacokinetics0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for GPX1
        HETE and HPETE biosynthesis and metabolism
    Glutathione metabolism


    2 Cell Signaling Technology (CST) Pathways for GPX1
        Lymphocyte Signaling
    Glucose / Energy Metabolism

    2 GeneGo (Thomson Reuters) Pathways for GPX1
        HETE and HPETE biosynthesis and metabolism
    Glutathione metabolism

    5/7 BioSystems Pathways for GPX1 (see all 7)
        Selenium Metabolism and Selenoproteins
    Oxidative Stress
    Selenium Pathway
    Folate Metabolism
    Direct p53 effectors

    5/9        Reactome Pathways for GPX1 (see all 9)
        Metabolism of nucleotides
    Metabolism
    Purine metabolism
    Arachidonic acid metabolism
    Purine catabolism

    3 PharmGKB Pathways for GPX1
        Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
    Doxorubicin Pathway, Pharmacokinetics
    Oxidative Stress Regulatory Pathway (Erythrocyte)

    5         Kegg Pathways  (Kegg details for GPX1):
        Glutathione metabolism
    Arachidonic acid metabolism
    Thyroid hormone synthesis
    Amyotrophic lateral sclerosis (ALS)
    Huntington's disease


    GPX1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GPX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/40 Interacting proteins for GPX1 (P072032, 3 ENSP000004073754) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166592, 3MINT-8261197 I2D: score=2 
    ABL1P005193, ENSP000003614234I2D: score=3 STRING: ENSP00000361423
    ABL2P426843, ENSP000003565954I2D: score=1 STRING: ENSP00000356595
    ATG4BQ9Y4P13I2D: score=1 
    ALOX15BENSP000003695304STRING: ENSP00000369530
    About this table

    Gene Ontology (GO): 5/50 biological process terms (GO ID links to tree view) (see all 50):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000302response to reactive oxygen species ----
    GO:0001659temperature homeostasis IEA--
    GO:0001885endothelial cell development IEA--
    GO:0002862negative regulation of inflammatory response to antigenic stimulus IEA--
    GO:0006144purine nucleobase metabolic process TAS--

    GPX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GPX1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GPX1

    10/11 HMDB Compounds for GPX1 (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    15(S)-HETE15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid (see all 17)54845-95-3--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--
    5(S)-Hydroperoxyeicosatetraenoic acid5-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid (see all 6)71774-08-8--
    5-HETE5(S)-HETE (see all 14)70608-72-9--
    5-HPETE5(S)-HPETE (see all 7)74581-83-2--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    Oxidized glutathioneGSSG (see all 4)27025-41-8--
    Seleniumselenium (see all 5)7782-49-2--
    Selenocysteine(2R)-2-amino-3-selanylpropanoate (see all 8)3614-08-2--

    1 DrugBank Compound for GPX1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17513408 17561443 17387467 17510403 17297093

    10/50 Novoseek inferred chemical compound relationships for GPX1 gene (see all 50)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenium 82.2 102 18940188 (8), 19415410 (7), 17625244 (4), 17052796 (3) (see all 36)
    selenocysteine 80.9 20 9488664 (2), 10970865 (2), 16354666 (2), 16764674 (1) (see all 10)
    selenite 73.7 8 19033020 (3), 17150329 (2), 12896980 (1), 17115890 (1) (see all 5)
    manganese superoxide 71.3 16 16538174 (1), 15496407 (1), 16945136 (1), 18379781 (1) (see all 12)
    h2o2 60.4 42 8824885 (3), 17886026 (2), 8597083 (1), 18853169 (1) (see all 18)
    superoxide 58.2 55 14633623 (2), 14573732 (2), 14962293 (2), 20083859 (2) (see all 34)
    oxygen 57.6 17 12398936 (2), 14633623 (1), 15082714 (1), 19415410 (1) (see all 13)
    12-hpete 54.1 3 17608719 (1), 11115402 (1)
    gsts 48 3 12140174 (1), 18449862 (1), 18664505 (1)
    8-oxo-dg 44.3 3 16615267 (1), 16448453 (1), 10657953 (1)

    Search CenterWatch for drugs/clinical trials and news about GPX1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GPX1 gene (2 alternative transcripts): 
    NM_000581.2  NM_201397.1  

    Unigene Cluster for GPX1:

    Glutathione peroxidase 1
    Hs.76686  [show with all ESTs]
    Unigene Representative Sequence: BM478682
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419783(uc021wxw.1) ENST00000419349(uc021wxx.1) ENST00000496791

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GPX1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GPX1
    SwitchGear 3'UTR luciferase reporter plasmidGPX1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GPX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPX1
    Clone
    Products:
         
    OriGene clones in human, mouse for GPX1 (see all 9)
    OriGene ORF clones in mouse, rat for GPX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GPX1 (NM_201397)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPX1
    Sirion Biotech Customized lentivirus for stable overexpression of GPX1 
                         Customized lentivirus expression plasmids for stable overexpression of GPX1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GPX1
    OriGene qSTAR qPCR primer pairs in human, mouse for GPX1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GPX1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPX1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPX1

    Additional mRNA sequence: 

    AK130160.1 AK225835.1 BC000742.2 BC007865.2 BC070258.1 M21304.1 X13709.1 X13710.1 
    Y00433.1 

    24/28 DOTS entries (see all 28):

    DT.100695209  DT.95377672  DT.120904358  DT.453375  DT.120904391  DT.120904697  DT.95377397  DT.100660428 
    DT.419998  DT.100660424  DT.120904690  DT.100853695  DT.100878930  DT.40133618  DT.120904378  DT.120904525 
    DT.100660420  DT.120904753  DT.100660421  DT.100660426  DT.101986123  DT.120904496  DT.120904805  DT.121133741 

    24/2393 AceView cDNA sequences (see all 2393):

    BM976767 BM751450 CB137459 CA394686 AA630985 BM461463 BU628811 BU174214 
    BU628124 BI258857 BM787053 BM788083 W94542 NM_001664 AI818316 AI359614 
    BQ721697 CR598647 AW157503 CK430592 BM473468 AA588820 AU121512 AW576281 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPX1 expression in normal human tissues (normalized intensities)      GPX1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTTCGAGA
    GPX1 Expression
    About this image


    GPX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             brain/midbrain   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             sensory organ/ear/inner ear   

    See GPX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GPX1

    SOURCE GeneReport for Unigene cluster: Hs.76686
        SABiosciences Expression via Pathway-Focused PCR Arrays including GPX1 (see all 9): 
              Multiple Sclerosis in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Drug Metabolism in human mouse rat
              Mitochondria in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GPX1
    OriGene qSTAR qPCR primer pairs in human, mouse for GPX1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GPX1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPX1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPX1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GPX1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpx11 , 5 glutathione peroxidase 11, 5 85.71(n)1
    88.27(a)1
      9 (59.24 cM)5
    147751  NM_008160.61  NP_032186.21 
     1083390805 
    chicken
    (Gallus gallus)
    Aves LOC1008571151 glutathione peroxidase 1-like 74.07(n)
    73.54(a)
      100857115  XM_003641995.1  XP_003642043.1 
    lizard
    (Anolis carolinensis)
    Reptilia GPX16
    Glutathione peroxidase
    71(a)
    1 ↔ 1
    2(147492705-147499692)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.19062 Xenopus laevis transcribed sequence with weak similarity more 75.69(n)    CD302356.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd42f122 Transcribed sequence with weak similarity to protein more 77.57(n)    57057448 
    worm
    (Caenorhabditis elegans)
    Secernentea gpx-36
    gpx-46
    (see all 3)
    Protein Y94H6A.4
    (see all 3)
    29(a)
    28(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    X(9587942-9588879)
    IV(2673098-2674734)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HYR16
    GPX26
    (see all 3)
    Thiol peroxidase that functions as a hydroperoxide...
    Phospholipid hydroperoxide glutathione peroxidase ...
    (see all 3)
    35(a)
    33(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    IX(423128-423619)
    II(707528-708016)


    ENSEMBL Gene Tree for GPX1 (if available)
    TreeFam Gene Tree for GPX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GPX1 gene
    GPX62  GPX52  GPX22  GPX72  GPX42  GPX32  GPX82  
    4 SIMAP similar genes for GPX1 using alignment to 3 protein entries:     GPX1_HUMAN (see all proteins):
    GPX2    GPX3    GPX5    GPX6

    GPX1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for GPX1
    PGOHUM00000239055 PGOHUM00000241193


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/118 SNPs in GPX1 are shown (see all 118)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10504501,2,4
    C,F,Anon-pathogenic149327125(-) AGGGCC/TCAGCT 3 P L ut31 mis114Minor allele frequency- T:0.26MN NS NA EU 2130
    rs1159669101,2
    F--49326407(+) CAGGCC/TAGGAG 2 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1472588191,2
    C--49326548(+) TCGCCA/GGGCCG 2 -- ds50010--------
    rs1868588571,2
    --49326687(+) TAGCCA/GGGCGT 2 -- ds50010--------
    rs1118125491,2
    C,F--49326691(+) CGGGCG/TTGGTG 2 -- ds50011Minor allele frequency- T:0.50NA 2
    rs3770716841,2
    C--49326851(+) AAAAA-/GAAAAG 2 -- ds50010--------
    rs2009084681,2
    C--49326856(-) TTTTTC/TTTTTC 2 -- ds50010--------
    rs1407251681,2
    --49326879(+) GACAAC/TGACAC 2 -- ds50010--------
    rs10506141,2
    C,F--49326927(-) TCCCCA/C/GCTAAT 4 -- ut312NS NA 178
    rs10505961,2
    C--49326952(-) AGTRTA/C/G/
            
    TGCCA
    6 -- ut315MN 404

    HapMap Linkage Disequilibrium report for GPX1 (49394609 - 49396033 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for GPX1: --

    Human Gene Mutation Database (HGMD): GPX1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GPX1
    DNA2.0 Custom Variant and Variant Library Synthesis for GPX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 138320    OMIM disorders: --

    20/97 diseases for GPX1 (see all 97):    About MalaCards
    keshan disease    stress cardiomyopathy    oral cavity cancer    spermatic cord torsion
    diabetic polyneuropathy    thoracic aortic aneurysm    barrett's adenocarcinoma    hyperhomocysteinemia
    tardive dyskinesia    diabetic neuropathy    toxic encephalopathy    sickle cell anemia
    bronchopulmonary dysplasia    phenylketonuria    hemolytic anemia    mastitis
    polyneuropathy    insulinoma    viral hepatitis    breast cancer

    12 diseases from the University of Copenhagen DISEASES database for GPX1:
    Vascular disease     Diabetes mellitus     Keshan disease     Toxic encephalopathy
    Cancer     Heart disease     Neurodegenerative disease     Brain disease
    Hyperglycemia     Kidney failure     Lung disease     Liver disease

    GPX1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/29 Novoseek inferred disease relationships for GPX1 gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenium deficiency 72.2 4 18940188 (3)
    cancer 28.4 18 16317164 (2), 9792801 (2), 15203190 (2), 19826042 (2) (see all 10)
    hyperhomocysteinemia 26.6 4 18237028 (1), 14656025 (1), 17822368 (1)
    atherosclerosis 26.3 18 17350371 (4), 17420349 (3), 15331559 (1), 17255533 (1) (see all 6)
    hepatitis acute viral 26.2 1 1803152 (1)
    cardiovascular diseases 19.7 3 17822368 (1), 19327385 (1), 18541150 (1)
    insulinoma 19.1 1 14962293 (1)
    cancer lung 15.5 14 16615267 (5), 17052796 (2), 8001233 (1), 14744747 (1) (see all 6)
    breast carcinoma 13.5 3 11502879 (1), 12398936 (1), 12810669 (1)
    breast cancer 11.2 23 12810669 (4), 16945136 (4), 7850813 (3), 14744747 (3) (see all 10)

    Genatlas disease: GPX1
    hemolytic anemia

    Genetic Association Database (GAD): GPX1
    Human Genome Epidemiology (HuGE) Navigator: GPX1 (123 documents)

    Export disorders for GPX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GPX1 gene, integrated from 9 sources (see all 434):
    (articles sorted by number of sources associating them with GPX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in Japanese type 2 diabetic patients. (PubMed id 15331559)1, 2, 4, 9 Hamanishi T.... Nanjo K. (2004)
    2. Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant. (PubMed id 15247771)1, 2, 4, 9 Ichimura Y.... Kato T. (2004)
    3. Association between the GCG polymorphism of the selenium dependent GPX1 gene and the risk of young onset prostate cancer. (PubMed id 12496980)1, 2, 4, 9 Kote-Jarai Z.... Eeles R. (2002)
    4. Association between GPx1 Pro198Leu polymorphism, GPx1 activity and plasma selenium concentration in humans. (PubMed id 19415410)1, 4, 9 Jablonska E....Boffetta P. (2009)
    5. Interaction of glutathione peroxidase-1 and selenium in endemic dilated cardiomyopathy. (PubMed id 18940188)1, 4, 9 Lei C....Zhu Y. (2009)
    6. [Effects of oxidative DNA damage and genetic polymorphism of the glutathione peroxidase 1 (GPX1) and 8-oxoguanine glycosylase 1 (hOGG1) on lung cancer] (PubMed id 16615267)1, 4, 9 Lee C.H....Kim Y.D. (2006)
    7. Glutathione peroxidase 1 (GPX1) genetic polymorphism, erythrocyte GPX activity, and prostate cancer risk. (PubMed id 18563616)1, 4, 9 Arsova-Sarafinovska Z....Dimovski A.J. (2008)
    8. Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography. (PubMed id 17825092)1, 4, 9 Nemoto M....Tajima N. (2007)
    9. Genotype-activity relationship for Mn-superoxide dismutase, glutathione peroxidase 1 and catalase in humans. (PubMed id 16538174)1, 4, 9 Bastaki M....Holland N. (2006)
    10. Sex determines the influence of smoking and gene polymorphism on glutathione peroxidase activity in erythrocytes. (PubMed id 19125369)1, 4, 9 Malling T.H....Omland A.9. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2876 HGNC: 4553 AceView: RHOA Ensembl:ENSG00000233276 euGenes: HUgn2876
    ECgene: GPX1 Kegg: 2876 H-InvDB: GPX1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GPX1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GPX1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/gpx1/
    Wikipedia http://en.wikipedia.org/wiki/Glutathione_peroxidase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GPX1 gene:
    Search GeneIP for patents involving GPX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of GPX1
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for GPX1 (Glutathione Peroxidase 1/GPX1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GPX1   OriGene RNAi products in human, mouse, rat for GPX1  
     OriGene qPCR primer pairs and template standards for GPX1   OriGene Protein Over-expression Lysate for GPX1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GPX1  
     OriGene qSTAR qPCR primer pairs in human, mouse for GPX1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GPX1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GPX1   OriGene Custom Protein Services for GPX1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GPX1
     QIAGEN SeqTarget long-range PCR primers for resequencing GPX1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPX1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPX1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPX1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPX1
     GenScript Custom Purified and Recombinant Proteins Services for GPX1 GenScript cDNA clones with any tag delivered in your preferred vector for GPX1
     GenScript Custom Assay Services for GPX1 GenScript Custom Superior Antibodies Services for GPX1
     GenScript Custom overexpressing Cell Line Services for GPX1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for GPX1 

     Regulatory tfbs in GPX1 promoter
     Search Chromatin IP Primers for GPX1
     RT2 qPCR Primer Assay in human, mouse, rat GPX1
     GNC Network for GPX1
     SABiosciences PCR Arrays including human, mouse, rat GPX1
     Search Tocris compounds for GPX1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Assays/Proteins for GPX1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GPX1 antibodies
     GPX1 proteins
     Antibodies for GPX1
     See all of Abcam's Antibodies, Kits and Proteins for GPX1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for GPX1




     Proteins for GPX1
     Antibodies for GPX1
     ELISAs for GPX1
     CLIAs for GPX1
     Search LifeMap BioReagents cell lines for GPX1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPX1
     SwitchGear 3'UTR luciferase reporter plasmids for GPX1
     SwitchGear Promoter luciferase reporter plasmids for GPX1
     ThermoFisher Antibody for GPX1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPX1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GPX1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GPX1
    Customized:
     lentivirus for stable overexpression of GPX1
     lentivirus expression plasmids for stable overexpression of GPX1
     adenovirus for overexpression of GPX1
     LSBio Antibodies in human, mouse, rat for GPX1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GPX1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4