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Aliases for GPX1 Gene

Aliases for GPX1 Gene

  • Glutathione Peroxidase 1 2 3
  • Cellular Glutathione Peroxidase 3 4
  • EC 4 63
  • GSHPx-1 3 4
  • GPx-1 3 4
  • EC 1.11.1 63
  • GSHPX1 3
  • GPXD 3

External Ids for GPX1 Gene

Previous GeneCards Identifiers for GPX1 Gene

  • GC03P048736
  • GC03P048542
  • GC03M049249
  • GC03M049353
  • GC03M049369
  • GC03M049360

Summaries for GPX1 Gene

Entrez Gene Summary for GPX1 Gene

  • This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPX1 Gene

GPX1 (Glutathione Peroxidase 1) is a Protein Coding gene. Diseases associated with GPX1 include hemolytic anemia due to glutathione peroxidase deficiency and keshan disease. Among its related pathways are Metabolism and Glucose / Energy Metabolism. GO annotations related to this gene include SH3 domain binding and selenium binding. An important paralog of this gene is GPX4.

UniProtKB/Swiss-Prot for GPX1 Gene

  • Protects the hemoglobin in erythrocytes from oxidative breakdown

Gene Wiki entry for GPX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPX1 Gene

Genomics for GPX1 Gene

Regulatory Elements for GPX1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GPX1 Gene

49,357,176 bp from pter
49,358,600 bp from pter
1,425 bases
Minus strand

Genomic View for GPX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPX1 Gene

Proteins for GPX1 Gene

  • Protein details for GPX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutathione peroxidase 1
    Protein Accession:
    Secondary Accessions:
    • E9PAS1
    • Q7Z5H1
    • Q9BW12

    Protein attributes for GPX1 Gene

    203 amino acids
    Molecular mass:
    22088 Da
    Quaternary structure:
    • Homotetramer. Interacts with MIEN1

    Three dimensional structures from OCA and Proteopedia for GPX1 Gene

    Alternative splice isoforms for GPX1 Gene


neXtProt entry for GPX1 Gene

Proteomics data for GPX1 Gene at MOPED

Post-translational modifications for GPX1 Gene

  • During periods of oxidative stress, Sec-49 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPX1 Gene

Antibody Products

  • R&D Systems Antibodies for GPX1 (Glutathione Peroxidase 1/GPX1)
  • Cell Signaling Technology (CST) Antibodies for GPX1 (GPX1)

Domains & Families for GPX1 Gene

Protein Domains for GPX1 Gene

Suggested Antigen Peptide Sequences for GPX1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glutathione peroxidase family.
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX1: view

No data available for Gene Families for GPX1 Gene

Function for GPX1 Gene

Molecular function for GPX1 Gene

GENATLAS Biochemistry:
glutathione peroxidase 1,selenium dependent,cellular,catabolic pathway of activated oxygen species,free radical detoxification
UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O
UniProtKB/Swiss-Prot Function:
Protects the hemoglobin in erythrocytes from oxidative breakdown

Enzyme Numbers (IUBMB) for GPX1 Gene

Gene Ontology (GO) - Molecular Function for GPX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004602 glutathione peroxidase activity TAS --
GO:0005515 protein binding --
GO:0008430 selenium binding IEA --
GO:0017124 SH3 domain binding IPI 12893824
GO:0043295 glutathione binding IEA --
genes like me logo Genes that share ontologies with GPX1: view
genes like me logo Genes that share phenotypes with GPX1: view

Animal Models for GPX1 Gene

MGI Knock Outs for GPX1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPX1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for GPX1 Gene

Localization for GPX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX1 Gene


Subcellular locations from

Jensen Localization Image for GPX1 Gene COMPARTMENTS Subcellular localization image for GPX1 gene
Compartment Confidence
extracellular 5
cytosol 4
mitochondrion 4
endoplasmic reticulum 2
lysosome 2
nucleus 2
peroxisome 2
plasma membrane 2
vacuole 2
chloroplast 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GPX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 10833429
GO:0005739 mitochondrion IDA 10833429
GO:0005759 mitochondrial matrix TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with GPX1: view

Pathways & Interactions for GPX1 Gene

genes like me logo Genes that share pathways with GPX1: view

PCR Array Products

SIGNOR curated interactions for GPX1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GPX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species TAS --
GO:0001659 temperature homeostasis IEA --
GO:0001885 endothelial cell development IEA --
GO:0002862 negative regulation of inflammatory response to antigenic stimulus IEA --
GO:0006144 purine nucleobase metabolic process TAS --
genes like me logo Genes that share ontologies with GPX1: view

Drugs & Compounds for GPX1 Gene

(26) Drugs for GPX1 Gene - From: NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target, Target, cofactor 0
Doxorubicin Approved, Investigational Pharma Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1525
Iron Approved Pharma 957
Nitric Oxide Approved Pharma 540
Menadione Approved Nutra 183

(33) Additional Compounds for GPX1 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoic acid
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • 15-Hydroperoxyeicosatetraenoate
  • 15-Hydroperoxyeicosatetraenoic acid
  • 15-Hydroperoxyicosatetraenoate
5(S)-Hydroperoxyeicosatetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-HETE
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5(S)-Hydroxyeicosatetraenoate
  • 5(S)-Hydroxyeicosatetraenoic acid
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-HPETE
genes like me logo Genes that share compounds with GPX1: view

Transcripts for GPX1 Gene

mRNA/cDNA for GPX1 Gene

Unigene Clusters for GPX1 Gene

Glutathione peroxidase 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPX1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPX1 Gene

No ASD Table

Relevant External Links for GPX1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPX1 Gene

mRNA expression in normal human tissues for GPX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPX1 Gene

This gene is overexpressed in Whole Blood (x6.8).

Protein differential expression in normal tissues from HIPED for GPX1 Gene

This gene is overexpressed in Nasal epithelium (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPX1 Gene

SOURCE GeneReport for Unigene cluster for GPX1 Gene Hs.76686

genes like me logo Genes that share expression patterns with GPX1: view

Protein tissue co-expression partners for GPX1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GPX1 Gene

Orthologs for GPX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPX1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPX1 35
  • 85.99 (n)
  • 90.96 (a)
(Canis familiaris)
Mammalia GPX1 35
  • 90.18 (n)
  • 95.26 (a)
GPX1 36
  • 95 (a)
(Mus musculus)
Mammalia Gpx1 35
  • 86.23 (n)
  • 89.13 (a)
Gpx1 16
Gpx1 36
  • 86 (a)
(Pan troglodytes)
Mammalia GPX1 35
  • 99.65 (n)
  • 100 (a)
GPX1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gpx1 35
  • 83.69 (n)
  • 88.83 (a)
(Monodelphis domestica)
Mammalia GPX1 36
  • 81 (a)
(Gallus gallus)
Aves GPX1 35
  • 74.68 (n)
  • 75.41 (a)
GPX1 36
  • 75 (a)
(Anolis carolinensis)
Reptilia GPX1 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpx1 35
  • 68.11 (n)
  • 67.03 (a)
Str.9465 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1906 35
(Danio rerio)
Actinopterygii gpx1a 35
  • 67.21 (n)
  • 70.11 (a)
wufd42f12 35
gpx1a 36
  • 71 (a)
Species with no ortholog for GPX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPX1 Gene

Gene Tree for GPX1 (if available)
Gene Tree for GPX1 (if available)

Paralogs for GPX1 Gene

Paralogs for GPX1 Gene

(4) SIMAP similar genes for GPX1 Gene using alignment to 3 proteins: Pseudogenes for GPX1 Gene

genes like me logo Genes that share paralogs with GPX1: view

Variants for GPX1 Gene

Sequence variations from dbSNP and Humsavar for GPX1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1050450 Benign, - 49,357,401(-) AGGGC(C/T)CAGCT reference, missense, utr-variant-3-prime
rs1050569 -- 49,357,287(-) GGAAC(A/C)CCTTG utr-variant-3-prime
rs1050593 -- 49,357,230(-) CCAGT(A/C/G/T)TRTGC utr-variant-3-prime
rs1050596 -- 49,357,228(-) AGTRT(A/C/G/T)TGCCA utr-variant-3-prime
rs1050614 -- 49,357,203(-) TCCCC(A/C/G)CTAAT utr-variant-3-prime

Variation tolerance for GPX1 Gene

Residual Variation Intolerance Score: 62.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.57; 77.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPX1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPX1 Gene

Disorders for GPX1 Gene

MalaCards: The human disease database

(15) MalaCards diseases for GPX1 Gene - From: OMIM, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
hemolytic anemia due to glutathione peroxidase deficiency
  • glutathione peroxidase deficiency
keshan disease
  • caused by deficiency of selenium in the diet
  • iieocolitis
pthirus pubis infestation
  • infestation by phthirus pubis
- elite association
Search GPX1 in MalaCards View complete list of genes associated with diseases

Genatlas disease for GPX1 Gene

hemolytic anemia

Relevant External Links for GPX1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GPX1: view

No data available for UniProtKB/Swiss-Prot for GPX1 Gene

Publications for GPX1 Gene

  1. Native specific activity of glutathione peroxidase (GPx-1), phospholipid hydroperoxide glutathione peroxidase (PHGPx) and glutathione reductase (GR) does not differ between normo- and hypomotile human sperm samples. (PMID: 15679624) Ursini F. … Maiorino M. (Int. J. Androl. 2005) 25 26 67
  2. Genetic variant of glutathione peroxidase 1 in autism. (PMID: 19195803) Ming X. … Buyske S. (Brain Dev. 2010) 23 67
  3. Hydroxyurea-induced expression of glutathione peroxidase 1 in red blood cells of individuals with sickle cell anemia. (PMID: 19951064) Cho C.S. … Rhee S.G. (Antioxid. Redox Signal. 2010) 23 67
  4. Missense polymorphisms in three oxidative-stress enzymes (GSTP1, SOD2, and GPX1) and dyskinesias in Russian psychiatric inpatients from Siberia. (PMID: 20041472) Al Hadithy A.F. … Loonen A.J. (Hum Psychopharmacol 2010) 23 67
  5. Irreversible inactivation of glutathione peroxidase 1 and reversible inactivation of peroxiredoxin II by H2O2 in red blood cells. (PMID: 20070187) Cho C.S. … Rhee S.G. (Antioxid. Redox Signal. 2010) 23 67

Products for GPX1 Gene

Sources for GPX1 Gene

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