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GPX1 Gene

protein-coding   GIFtS: 70
GCID: GC03M049369

Glutathione Peroxidase 1

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutathione Peroxidase 11 2     EC 1.11.1.93 8
Cellular Glutathione Peroxidase2 3     GPXD2 5
GPx-12 3     GSHPX12
GSHPx-12 3     EC 1.11.18

External Ids:    HGNC: 45531   Entrez Gene: 28762   Ensembl: ENSG000002332767   OMIM: 1383205   UniProtKB: P072033   

Export aliases for GPX1 gene to outside databases

Previous GC identifers: GC03P048736 GC03P048542 GC03M049249 GC03M049353


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GPX1 Gene:
This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the
detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein
is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active
site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon.
In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which
includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA
repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants
encoding distinct isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for GPX1 Gene:
GPX1 (glutathione peroxidase 1) is a protein-coding gene. Diseases associated with GPX1 include stress cardiomyopathy, and keshan disease. GO annotations related to this gene include SH3 domain binding and glutathione peroxidase activity. An important paralog of this gene is GPX6.

UniProtKB/Swiss-Prot: GPX1_HUMAN, P07203
Function: Protects the hemoglobin in erythrocytes from oxidative breakdown

Gene Wiki entry for GPX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPX1 gene promoter:
         PPAR-gamma1   AP-1   p53   ATF-2   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPX1 promoter sequence
   Search Chromatin IP Primers for GPX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

GPX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPX1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M049369:  view genomic region     (about GC identifiers)

Start:
49,394,609 bp from pter      End:
49,396,033 bp from pter
Size:
1,425 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GPX1_HUMAN, P07203 (See protein sequence)
Recommended Name: Glutathione peroxidase 1  
Size: 203 amino acids; 22088 Da
Subunit: Homotetramer. Interacts with MIEN1
1 PDB 3D structure from and Proteopedia for GPX1:
2F8A (3D)    
Secondary accessions: E9PAS1 Q7Z5H1 Q9BW12
Alternative splicing: 2 isoforms:  P07203-1   P07203-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for GPX1: NX_P07203

Explore proteomics data for GPX1 at MOPED

Post-translational modifications: 

  • During periods of oxidative stress, Sec-49 may react with a superoxide radical, irreversibly lose hydroselenide
    and be converted to dehydroalanine (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GPX1 (P07203) (see all 18)
     RRYSRRF  WNFEKFL  PVCRNDV  FPCNQFG 


    See GPX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000572.2  NP_958799.1  

    ENSEMBL proteins: 
     ENSP00000407375   ENSP00000391316  
    Reactome Protein details: P07203

    GPX1 Human Recombinant Protein Products:

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    Novus Biologicals GPX1 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GPX1
    Cloud-Clone Corp. Proteins for GPX1

    GPX1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GPX1
    R&D Systems Antibodies for GPX1 (Glutathione Peroxidase 1/GPX1)
    Cell Signaling Technology (CST) Antibodies for GPX1 
    OriGene Antibodies for GPX1
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    Novus Biologicals GPX1 Antibodies
    Abcam antibodies for GPX1
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    ThermoFisher Antibody for GPX1
    LSBio Antibodies in human, mouse, rat for GPX1

    GPX1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems DNA Damage/Repair Kits & Reagents for GPX1 (Glutathione Peroxidase 1/GPX1)
    GenScript Custom Assay Services for GPX1
    Enzo Life Sciences assays for GPX1
    Cloud-Clone Corp. ELISAs for GPX1
    Cloud-Clone Corp. CLIAs for GPX1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR000889 Glutathione_peroxidase

    Graphical View of Domain Structure for InterPro Entry P07203

    ProtoNet protein and cluster: P07203

    1 Blocks protein domain: IPB000889 Glutathione peroxidase

    UniProtKB/Swiss-Prot: GPX1_HUMAN, P07203
    Similarity: Belongs to the glutathione peroxidase family


    GPX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPX1_HUMAN, P07203
    Function: Protects the hemoglobin in erythrocytes from oxidative breakdown
    Catalytic activity: 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O

         Genatlas biochemistry entry for GPX1:
    glutathione peroxidase 1,selenium dependent,cellular,catabolic pathway of activated oxygen species,free radical
    detoxification

         Enzyme Numbers (IUBMB): EC 1.11.1.91 2 EC 1.11.12

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004602glutathione peroxidase activity TAS--
    GO:0004866endopeptidase inhibitor activity ----
    GO:0005515protein binding ----
    GO:0008430selenium binding IEA--
    GO:0017124SH3 domain binding IPI12893824
         
    GPX1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GPX1:
     Increased viability after born 

         13 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Gpx1):
     behavior/neurological  cellular  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     nervous system  no phenotypic analysis  vision/eye 

    GPX1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GPX1: Gpx1tm1Kola Gpx1tm1Ysh Gpx1tm1Mgr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GPX1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GPX1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GPX1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GPX1

    miRNA
    Products:
        
    miRTarBase miRNAs that target GPX1:
    hsa-mir-92b-3p (MIRT040633)

    Block miRNA regulation of human, mouse, rat GPX1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate GPX1
    SwitchGear 3'UTR luciferase reporter plasmidGPX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GPX1
    Predesigned siRNA for gene silencing in human, mouse, rat GPX1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GPX1

    Clone
    Products:
         
    OriGene clones in human, mouse for GPX1 (see all 11)
    OriGene ORF clones in mouse, rat for GPX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GPX1 (NM_201397)
    Sino Biological Human cDNA Clone for GPX1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPX1

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GPX1_HUMAN, P07203: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion4
    extracellular3
    cytoskeleton2
    endoplasmic reticulum2
    nucleus2
    peroxisome2
    plasma membrane2
    vacuole2
    lysosome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA10833429
    GO:0005759mitochondrial matrix TAS--
    GO:0005829cytosol TAS--

    GPX1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GPX1 About   (see all 17)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.65
    Glutathione metabolism0.45
    Glutathione metabolism0.65
    glutathione redox reactions I0.00
    2Arachidonic acid metabolism
    Arachidonic acid metabolism0.41
    Synthesis of 12-eicosatetraenoic acid derivatives0.00
    Arachidonic acid metabolism0.40
    Synthesis of 5-eicosatetraenoic acids0.00
    HETE and HPETE biosynthesis and metabolism0.33
    Synthesis of 15-eicosatetraenoic acid derivatives0.00
    3Amyotrophic lateral sclerosis (ALS)
    Amyotrophic lateral sclerosis (ALS)0.63
    Amyotrophic lateral sclerosis (ALS)0.63
    4Detoxification of Reactive Oxygen Species
    Detoxification of Reactive Oxygen Species
    Oxidative Stress Regulatory Pathway (Erythrocyte)0.00
    5Purine metabolism (REACTOME)
    Purine metabolism0.42
    Purine catabolism0.00
    Metabolism of nucleotides0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for GPX1
        Lymphocyte Signaling
    Glucose / Energy Metabolism

    2 GeneGo (Thomson Reuters) Pathways for GPX1
        HETE and HPETE biosynthesis and metabolism
    Glutathione metabolism

    Selected BioSystems Pathways for GPX1 (see all 8)
        Selenium Metabolism and Selenoproteins
    Oxidative Stress
    Amyotrophic lateral sclerosis (ALS)
    Folate Metabolism
    Selenium Pathway


    5 Reactome Pathways for GPX1
        Detoxification of Reactive Oxygen Species
    Synthesis of 15-eicosatetraenoic acid derivatives
    Purine catabolism
    Synthesis of 12-eicosatetraenoic acid derivatives
    Synthesis of 5-eicosatetraenoic acids

    3 PharmGKB Pathways for GPX1
        Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
    Doxorubicin Pathway, Pharmacokinetics
    Oxidative Stress Regulatory Pathway (Erythrocyte)

    5 Kegg Pathways  (Kegg details for GPX1):
        Glutathione metabolism
    Arachidonic acid metabolism
    Thyroid hormone synthesis
    Amyotrophic lateral sclerosis (ALS)
    Huntington's disease


    GPX1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GPX1 (see all 9): 
              Multiple Sclerosis in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Drug Metabolism in human mouse rat
              Mitochondria in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GPX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GPX1 (P072032, 3 ENSP000004073754) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166592, 3MINT-8261197 I2D: score=2 
    ABL1P005193, ENSP000003614234I2D: score=3 STRING: ENSP00000361423
    ABL2P426843, ENSP000003565954I2D: score=1 STRING: ENSP00000356595
    ATG4BQ9Y4P13I2D: score=1 
    ALOX15BENSP000003695304STRING: ENSP00000369530
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 59):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000302response to reactive oxygen species ----
    GO:0001659temperature homeostasis IEA--
    GO:0001885endothelial cell development IEA--
    GO:0002862negative regulation of inflammatory response to antigenic stimulus IEA--
    GO:0006144purine nucleobase metabolic process TAS--

    GPX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPX1

    Selected HMDB Compounds for GPX1 (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    15(S)-HETE15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid (see all 17)54845-95-3--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--
    5(S)-Hydroperoxyeicosatetraenoic acid5-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid (see all 6)71774-08-8--
    5-HETE5(S)-HETE (see all 14)70608-72-9--
    5-HPETE5(S)-HPETE (see all 7)74581-83-2--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    Oxidized glutathioneGSSG (see all 4)27025-41-8--
    Seleniumselenium (see all 5)7782-49-2--
    Selenocysteine(2R)-2-amino-3-selanylpropanoate (see all 8)3614-08-2--

    1 DrugBank Compound for GPX1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17513408 17561443 17387467 17510403 17297093

    Selected Novoseek inferred chemical compound relationships for GPX1 gene (see all 50)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenium 82.2 102 18940188 (8), 19415410 (7), 17625244 (4), 17052796 (3) (see all 36)
    selenocysteine 80.9 20 9488664 (2), 10970865 (2), 16354666 (2), 16764674 (1) (see all 10)
    selenite 73.7 8 19033020 (3), 17150329 (2), 12896980 (1), 17115890 (1) (see all 5)
    manganese superoxide 71.3 16 16538174 (1), 15496407 (1), 16945136 (1), 18379781 (1) (see all 12)
    h2o2 60.4 42 8824885 (3), 17886026 (2), 8597083 (1), 18853169 (1) (see all 18)
    superoxide 58.2 55 14633623 (2), 14573732 (2), 14962293 (2), 20083859 (2) (see all 34)
    oxygen 57.6 17 12398936 (2), 14633623 (1), 15082714 (1), 19415410 (1) (see all 13)
    12-hpete 54.1 3 17608719 (1), 11115402 (1)
    gsts 48 3 12140174 (1), 18449862 (1), 18664505 (1)
    8-oxo-dg 44.3 3 16615267 (1), 16448453 (1), 10657953 (1)



    GPX1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GPX1 gene (2 alternative transcripts): 
    NM_000581.2  NM_201397.1  

    Unigene Cluster for GPX1:

    Glutathione peroxidase 1
    Hs.76686  [show with all ESTs]
    Unigene Representative Sequence: BM478682
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419783(uc021wxw.1) ENST00000419349(uc021wxx.1) ENST00000496791

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GPX1 (NM_201397)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPX1
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GPX1
      QuantiTect SYBR Green Assays in human, mouse, rat GPX1
      QuantiFast Probe-based Assays in human, mouse, rat GPX1

    Additional mRNA sequence: 

    AK130160.1 AK225835.1 BC000742.2 BC007865.2 BC070258.1 M21304.1 X13709.1 X13710.1 
    Y00433.1 

    Selected DOTS entries (see all 28):

    DT.100695209  DT.95377672  DT.120904358  DT.453375  DT.120904391  DT.120904697  DT.95377397  DT.100660428 
    DT.419998  DT.100660424  DT.120904690  DT.100853695  DT.100878930  DT.40133618  DT.120904378  DT.120904525 
    DT.100660420  DT.120904753  DT.100660421  DT.100660426  DT.101986123  DT.120904496  DT.120904805  DT.121133741 

    Selected AceView cDNA sequences (see all 2393):

    BE383307 NM_201397 BU159642 CD368422 BQ435346 BQ889768 BF797863 CR594903 
    BQ229770 BM042275 CR607713 BX420256 AA588820 BQ776172 BM768708 N43006 
    AW302382 BM994352 CR595947 BM542411 BX446488 AU121512 BF027317 CB107420 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    GPX1 expression in normal human tissues (normalized intensities)      GPX1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTTCGAGA
    GPX1 Expression
    About this image


    GPX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Eye (Sensory Organs)
             Lens
    GPX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.76686
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GPX1 (see all 9): 
              Multiple Sclerosis in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Drug Metabolism in human mouse rat
              Mitochondria in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GPX1
    OriGene qSTAR qPCR primer pairs in human, mouse for GPX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GPX1
    QuantiTect SYBR Green Assays in human, mouse, rat GPX1
    QuantiFast Probe-based Assays in human, mouse, rat GPX1
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GPX1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpx11 , 5 glutathione peroxidase 11, 5 86.23(n)1
    89.13(a)1
      9 (59.24 cM)5
    147751  NM_008160.61  NP_032186.21 
     1083390805 
    chicken
    (Gallus gallus)
    Aves GPX11 glutathione peroxidase 1 74.68(n)
    75.41(a)
      100857115  NM_001277853.1  NP_001264782.1 
    lizard
    (Anolis carolinensis)
    Reptilia GPX16
    glutathione peroxidase 1
    71(a)
    1 ↔ 1
    2(147492705-147499692)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.19062 Xenopus laevis transcribed sequence with weak similarity more 75.69(n)    CD302356.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd42f122 Transcribed sequence with weak similarity to protein more 77.57(n)    57057448 


    ENSEMBL Gene Tree for GPX1 (if available)
    TreeFam Gene Tree for GPX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GPX1 gene
    GPX62  GPX52  GPX22  GPX72  GPX42  GPX32  GPX82  
    4 SIMAP similar genes for GPX1 using alignment to 3 protein entries:     GPX1_HUMAN (see all proteins):
    GPX2    GPX3    GPX5    GPX6

    GPX1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for GPX1
    PGOHUM00000239055 PGOHUM00000241193


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GPX1 (see all 118)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10504501,2,,4
    C,F,Anon-pathogenic149327125(-) AGGGCC/TCAGCT 3 P L ut31 mis114Minor allele frequency- T:0.26MN NS NA EU 2130
    rs1159669101,2
    F--49326407(+) CAGGCC/TAGGAG 2 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1472588191,2
    C--49326548(+) TCGCCA/GGGCCG 2 -- ds50010--------
    rs1868588571,2
    --49326687(+) TAGCCA/GGGCGT 2 -- ds50010--------
    rs1118125491,2
    C,F--49326691(+) CGGGCG/TTGGTG 2 -- ds50011Minor allele frequency- T:0.50NA 2
    rs3770716841,2
    C--49326851(+) AAAAA-/GAAAAG 2 -- ds50010--------
    rs2009084681,2
    C--49326856(-) TTTTTC/TTTTTC 2 -- ds50010--------
    rs1407251681,2
    --49326879(+) GACAAC/TGACAC 2 -- ds50010--------
    rs10506141,2
    C,F--49326927(-) TCCCCA/C/GCTAAT 4 -- ut312NS NA 178
    rs10505961,2
    C--49326952(-) AGTRTA/C/G/
            
    TGCCA
    6 -- ut315MN 404

    HapMap Linkage Disequilibrium report for GPX1 (49394609 - 49396033 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for GPX1: --
    Human Gene Mutation Database (HGMD): GPX1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPX1
    DNA2.0 Custom Variant and Variant Library Synthesis for GPX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138320   
    OMIM disorders: 614164  
    Selected diseases for GPX1 (see all 104):    About MalaCards
    stress cardiomyopathy    keshan disease    hemolytic anemia due to glutathione peroxidase deficiency    oral cavity cancer
    spermatic cord torsion    diabetic polyneuropathy    barrett's adenocarcinoma    pseudoxanthoma elasticum
    hyperhomocysteinemia    thoracic aortic aneurysm    tardive dyskinesia    toxic encephalopathy
    diabetic neuropathy    sickle cell anemia    bronchopulmonary dysplasia    mastitis
    phenylketonuria    polyneuropathy    insulinoma    coronary artery disease

    12 diseases from the University of Copenhagen DISEASES database for GPX1:
    Vascular disease     Diabetes mellitus     Keshan disease     Toxic encephalopathy
    Cancer     Heart disease     Neurodegenerative disease     Brain disease
    Hyperglycemia     Kidney failure     Lung disease     Liver disease

    GPX1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for GPX1 gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenium deficiency 72.2 4 18940188 (3)
    cancer 28.4 18 16317164 (2), 9792801 (2), 15203190 (2), 19826042 (2) (see all 10)
    hyperhomocysteinemia 26.6 4 18237028 (1), 14656025 (1), 17822368 (1)
    atherosclerosis 26.3 18 17350371 (4), 17420349 (3), 15331559 (1), 17255533 (1) (see all 6)
    hepatitis acute viral 26.2 1 1803152 (1)
    cardiovascular diseases 19.7 3 17822368 (1), 19327385 (1), 18541150 (1)
    insulinoma 19.1 1 14962293 (1)
    cancer lung 15.5 14 16615267 (5), 17052796 (2), 8001233 (1), 14744747 (1) (see all 6)
    breast carcinoma 13.5 3 11502879 (1), 12398936 (1), 12810669 (1)
    breast cancer 11.2 23 12810669 (4), 16945136 (4), 7850813 (3), 14744747 (3) (see all 10)

    Genatlas disease: GPX1
    hemolytic anemia

    Genetic Association Database (GAD): GPX1
    Human Genome Epidemiology (HuGE) Navigator: GPX1 (123 documents)

    Export disorders for GPX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPX1 gene, integrated from 10 sources (see all 442):
    (articles sorted by number of sources associating them with GPX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in Japanese type 2 diabetic patients. (PubMed id 15331559)1, 2, 4, 9 Hamanishi T.... Nanjo K. (Diabetes 2004)
    2. Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant. (PubMed id 15247771)1, 2, 4, 9 Ichimura Y.... Kato T. (J. Urol. 2004)
    3. Association between the GCG polymorphism of the selenium dependent GPX1 gene and the risk of young onset prostate cancer. (PubMed id 12496980)1, 2, 4, 9 Kote-Jarai Z.... Eeles R. (Prostate Cancer Prostatic Dis. 2002)
    4. Association between GPx1 Pro198Leu polymorphism, GPx1 activity and plasma selenium concentration in humans. (PubMed id 19415410)1, 4, 9 Jablonska E....Boffetta P. (Eur J Nutr 2009)
    5. Interaction of glutathione peroxidase-1 and selenium in endemic dilated cardiomyopathy. (PubMed id 18940188)1, 4, 9 Lei C....Zhu Y. ( international journal of clinical chemistry 2009)
    6. [Effects of oxidative DNA damage and genetic polymorphism of the glutathione peroxidase 1 (GPX1) and 8-oxoguanine glycosylase 1 (hOGG1) on lung cancer]. (PubMed id 16615267)1, 4, 9 Lee C.H....Kim Y.D. (J Prev Med Public Health 2006)
    7. Glutathione peroxidase 1 (GPX1) genetic polymorphism, erythrocyte GPX activity, and prostate cancer risk. (PubMed id 18563616)1, 4, 9 Arsova-Sarafinovska Z....Dimovski A.J. (Int Urol Nephrol 2009)
    8. Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography. (PubMed id 17825092)1, 4, 9 Nemoto M....Tajima N. (Cardiovasc Diabetol 2007)
    9. Genotype-activity relationship for Mn-superoxide dismutase, glutathione peroxidase 1 and catalase in humans. (PubMed id 16538174)1, 4, 9 Bastaki M....Holland N. (Pharmacogenet. Genomics 2006)
    10. Sex determines the influence of smoking and gene polymorphism on glutathione peroxidase activity in erythrocytes. (PubMed id 19125369)1, 4, 9 Malling T.H....Omland A.9. (Scand. J. Clin. Lab. Invest. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2876 HGNC: 4553 AceView: RHOA Ensembl:ENSG00000233276 euGenes: HUgn2876
    ECgene: GPX1 Kegg: 2876 H-InvDB: GPX1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GPX1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GPX1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/gpx1/
    Wikipedia http://en.wikipedia.org/wiki/Glutathione_peroxidase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GPX1 gene:
    Search GeneIP for patents involving GPX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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