GPX1 Gene
protein-coding GIFtS: 68
GCID: GC03M049369
|
|
glutathione peroxidase 1
| |
Aliases
for GPX1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Glutathione Peroxidase 11 2 | | EC 1.11.1.93 8 | | Cellular Glutathione Peroxidase2 3 | | GPXD2 | | GPx-12 3 | | GSHPX12 | | GSHPx-12 3 | | EC 1.11.18 |
Export aliases for GPX1 gene to outside databasesPrevious GC identifers: GC03P048736 GC03P048542 GC03M049249 GC03M049353 |
Summaries
for GPX1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GPX1:
This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxificationof hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only afew proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathioneperoxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this proteinis characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles withfive, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantlyassociated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have beenfound for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: GPX1_HUMAN, P07203Function: Protects the hemoglobin in erythrocytes from oxidative breakdown
Gene Wiki entry for GPX1
|
Genomic Views
for GPX1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GPX1 gene promoter:
PPAR-gamma1 AP-1 p53 ATF-2 PPAR-gamma2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for GPX1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPX1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3GPX1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M049369: view genomic region
(about GC identifiers)
Start:
|
49,394,609 bp from pter |
End:
|
49,396,033 bp from pter |
Size:
|
1,425 bases |
Orientation:
|
minus strand |
|
Proteins
for GPX1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GPX1_HUMAN, P07203 (See
protein sequence)Recommended Name: Glutathione peroxidase 1 Size: 203 amino acids; 22088 Da
Subunit: Homotetramer. Interacts with MIEN1
Subcellular location: Cytoplasm
1 PDB 3D structure from  and Proteopedia  for GPX1:2F8A (3D)
Secondary accessions: Q7Z5H1 Q9BW12Explore the universe of human proteins at neXtProt for GPX1: NX_P07203
Post-translational modifications:
During periods of oxidative stress, Sec-49 may react with a superoxide radical, irreversibly lose hydroselenide and beconverted to dehydroalanine (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P07203
4/18 DME Specific Peptides for GPX1 (P07203) (see all 18)
GPX1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_000572.2 NP_958799.1
ENSEMBL proteins: ENSP00000407375 ENSP00000391316 Reactome Protein details: P07203
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
GPX1 for ontologies About GeneDecksing
GPX1 Antibody Products:
Assay Products for GPX1: |
Protein
Domains /
Families
for GPX1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GPX1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P07203ProtoNet protein and cluster: P07203 1 Blocks protein family: IPB000889 Glutathione peroxidase
UniProtKB/Swiss-Prot: GPX1_HUMAN, P07203Similarity: Belongs to the glutathione peroxidase family |
Function
for GPX1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GPX1_HUMAN, P07203Function: Protects the hemoglobin in erythrocytes from oxidative breakdownCatalytic activity: 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O Genatlas biochemistry entry for GPX1:glutathione peroxidase 1,selenium dependent,cellular,catabolic pathway of activated oxygen species,free radicaldetoxification
Enzyme Numbers (IUBMB): EC 1.11.1.91 2 EC 1.11.12
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPX1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPX1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): GPX1 (NM_201397) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GPX1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPX1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
GPX1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for GPX1:
Animal Models:
Mouse knock-outs for GPX1: Gpx1tm1Kola Gpx1tm1Ysh Gpx1tm1Mgr
12 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Gpx1):
GPX1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for GPX1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Glutathione metabolism | | | 2 | Arachidonic acid metabolism | | | 3 | Purine metabolism | | | 4 | Synthesis of 15-eicosatetraenoic acid derivatives | | | 5 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for GPX1
2 
Cell Signaling Technology (CST) Pathways for GPX1
2  GeneGo (Thomson Reuters) Pathways for GPX1
5/7  BioSystems Pathways for GPX1 (see all 7)
5/9 
Reactome Pathways for GPX1 (see all 9)
3  PharmGKB Pathways for GPX1
4 
Kegg Pathways (Kegg details for GPX1):
GPX1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GPX1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/40 Interacting proteins for GPX1 (P072032, 3 ENSP000004073754) via UniProtKB, MINT, STRING, and/or I2D (see all 40)About this table
Gene Ontology (GO): 5/48 biological process terms (GO ID links to tree view) (see all 48): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000302 | response to reactive oxygen species |
-- | -- | | GO:0001659 | temperature homeostasis |
IEA | -- | | GO:0001836 | release of cytochrome c from mitochondria |
IMP | 12221075 | | GO:0001885 | endothelial cell development |
IEA | -- | | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus |
IEA | -- |
GPX1 for ontologies About GeneDecksing
|
Drugs & Compounds
for GPX1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
GPX1 for compounds About GeneDecksing
 Browse Tocris compounds for GPX1
10/11 HMDB Compounds for GPX1 (see all 11) About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| 15(S)-HETE | 15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid (see all 17) | 54845-95-3 | -- | | 15(S)-HPETE | (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8) | 70981-96-3 | -- | | 5(S)-Hydroperoxyeicosatetraenoic acid | 5-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid (see all 6) | 71774-08-8 | -- | | 5-HETE | 5(S)-HETE (see all 14) | 70608-72-9 | -- | | 5-HPETE | 5(S)-HPETE (see all 7) | 74581-83-2 | -- | | Glutathione | 5-L-Glutamyl-L-cysteinylglycine (see all 32) | 70-18-8 | -- | | Hydrogen peroxide | Hydrogen peroxide (see all 44) | 7722-84-1 | -- | | Oxidized glutathione | GSSG (see all 4) | 27025-41-8 | -- | | Selenium | selenium (see all 5) | 7782-49-2 | -- | | Selenocysteine | (2R)-2-amino-3-selanylpropanoate (see all 8) | 3614-08-2 | -- |
1 DrugBank Compound for GPX1 About this table
10/50 Novoseek chemical compound relationships for GPX1 gene (see all 50) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| selenium |
82.2 |
102 |
18940188 (8), 19415410 (7), 17625244 (4), 17052796 (3) (see all 36) |
| selenocysteine |
80.9 |
20 |
9488664 (2), 10970865 (2), 16354666 (2), 16764674 (1) (see all 10) |
| selenite |
73.7 |
8 |
19033020 (3), 17150329 (2), 12896980 (1), 17115890 (1) (see all 5) |
| manganese superoxide |
71.3 |
16 |
16538174 (1), 15496407 (1), 16945136 (1), 18379781 (1) (see all 12) |
| h2o2 |
60.4 |
42 |
8824885 (3), 17886026 (2), 8597083 (1), 18853169 (1) (see all 18) |
| superoxide |
58.2 |
55 |
14633623 (2), 14573732 (2), 14962293 (2), 20083859 (2) (see all 34) |
| oxygen |
57.6 |
17 |
12398936 (2), 14633623 (1), 15082714 (1), 19415410 (1) (see all 13) |
| 12-hpete |
54.1 |
3 |
17608719 (1), 11115402 (1) |
| gsts |
48 |
3 |
12140174 (1), 18449862 (1), 18664505 (1) |
| 8-oxo-dg |
44.3 |
3 |
16615267 (1), 16448453 (1), 10657953 (1) |
Search CenterWatch for drugs/clinical trials and news about GPX1
|
Transcripts
for GPX1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GPX1 gene (2 alternative transcripts): NM_000581.2 NM_201397.1 Unigene Cluster for GPX1: Glutathione peroxidase 1 Hs.76686 [show with all ESTs]Unigene Representative Sequence: BM4786823 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000419783(uc021wxw.1) ENST00000419349(uc021wxx.1) ENST00000496791
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPX1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPX1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): GPX1 (NM_201397) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GPX1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPX1 |
Additional cDNA sequence: AK130160.1 AK225835.1 BC000742.2 BC007865.2 BC070258.1 M21304.1 X13709.1 X13710.1 Y00433.1 24/28 DOTS entries (see all 28): DT.100695209 DT.95377672 DT.120904358 DT.453375 DT.120904391 DT.120904697 DT.95377397 DT.100660428 DT.419998 DT.100660424 DT.120904690 DT.100853695 DT.100878930 DT.40133618 DT.120904378 DT.120904525 DT.100660420 DT.120904753 DT.100660421 DT.100660426 DT.101986123 DT.120904496 DT.120904805 DT.121133741 24/2393 AceView cDNA sequences (see all 2393): CR590795 BE550806 BM479295 AI359614 BM451075 BF343214 BE018854 F02985 N33344 BI833287 BC001360 BQ683364 BU165570 BQ935282 AU142544 BF437596 NM_201397 BM800293 BU627544 BM042413 AA295595 CR614049 BM672298 BG420058
GeneLoc Exon Structure
|
Expression
for GPX1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GPX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTTCGAGA
About this image
See GPX1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GPX1
SOURCE GeneReport for Unigene cluster: Hs.76686
SABiosciences Expression via Pathway-Focused PCR Arrays including GPX1 (see all 9):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPX1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GPX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPX1 |
Orthologs
for GPX1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for GPX1 gene from 6/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC1008571151 |
glutathione peroxidase 1-like |
74.07(n)
73.54(a) |
|
100857115 XM_003641995.1 XP_003642043.1 |
lizard
(Anolis carolinensis) |
Reptilia |
GPX16 |
-- |
72(a) |
1 ↔ 1 |
2(147492705-147499692) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.19062 |
Xenopus laevis transcribed sequence with weak similarity more |
75.69(n) |
|
CD302356.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufd42f122 |
Transcribed sequence with weak similarity to protein more |
77.57(n) |
|
57057448 |
worm
(Caenorhabditis elegans) |
Secernentea |
T09A12.26F55A3.56 |
Protein F55A3.5 |
30(a)20(a) |
possible orthologpossible ortholog |
IV(8222190-8223444) I(10781963-10782879) |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
btuE6 |
glutathione peroxidase |
35(a) |
1 → many |
Chromosome(1791582-1792133) |
ENSEMBL Gene Tree for GPX1 (if available)
TreeFam Gene Tree for GPX1 (if available) |
Paralogs
for GPX1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GPX1 gene
- GPX62 GPX52 GPX22 GPX72 GPX42 GPX32 GPX82
6 SIMAP similar genes for GPX1 using alignment to 4 protein entries: GPX1_HUMAN (see all proteins):GPX2 GPX3 GPX5 GPX6 GPX4 GPX8
GPX1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for GPX1
PGOHUM00000239055 PGOHUM00000241193
|
Genomic Variants
for GPX1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GPX1 (49394609 - 49396033 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GPX1: --
Human Gene Mutation Database (HGMD): GPX1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPX1 |
|
Disorders
/ Diseases
for GPX1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GPX1 for disorders About GeneDecksing
OMIM gene information: 138320
OMIM disorders: --
20/109  diseases for GPX1 (see all 109): About MalaCardshemolytic anemia due to glutathione peroxidase deficiency breast cancer spermatic cord torsion diffuse large b-cell lymphoma
age related macular degeneration amyotrophic lateral sclerosis (als) amyotrophic lateral sclerosis thoracic aortic aneurysm
b-cell lymphomas temporal lobe epilepsy non-hodgkin lymphoma tardive dyskinesia
type 2 diabetes mellitus aortic aneurysm type 1 diabetes mellitus hemolytic anemia
lateral sclerosis oral cavity cancer macular degeneration stress cardiomyopathy
2 diseases from the University of Copenhagen DISEASES database for GPX1:Keshan disease Vascular disease 10/29 Novoseek disease relationships for GPX1 gene (see all 29) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| selenium deficiency |
72.2 |
4 |
18940188 (3) |
| cancer |
28.4 |
18 |
16317164 (2), 9792801 (2), 15203190 (2), 19826042 (2) (see all 10) |
| hyperhomocysteinemia |
26.6 |
4 |
18237028 (1), 14656025 (1), 17822368 (1) |
| atherosclerosis |
26.3 |
18 |
17350371 (4), 17420349 (3), 15331559 (1), 17255533 (1) (see all 6) |
| hepatitis acute viral |
26.2 |
1 |
1803152 (1) |
| cardiovascular diseases |
19.7 |
3 |
17822368 (1), 19327385 (1), 18541150 (1) |
| insulinoma |
19.1 |
1 |
14962293 (1) |
| cancer lung |
15.5 |
14 |
16615267 (5), 17052796 (2), 8001233 (1), 14744747 (1) (see all 6) |
| breast carcinoma |
13.5 |
3 |
11502879 (1), 12398936 (1), 12810669 (1) |
| breast cancer |
11.2 |
23 |
12810669 (4), 16945136 (4), 7850813 (3), 14744747 (3) (see all 10) |
Genatlas disease: GPX1 hemolytic anemia
Genetic Association Database (GAD): GPX1
Human Genome Epidemiology (HuGE) Navigator: GPX1 (123 documents)
Export disorders for GPX1 gene to outside databases
|
Publications
for GPX1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GPX1 gene, integrated from 9 sources (see all 419):
(articles sorted by number of sources associating them with GPX1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in Japanese type 2 diabetic patients. (PubMed id 15331559)1, 2, 4, 9 Hamanishi T.... Nanjo K. (2004)
- Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant. (PubMed id 15247771)1, 2, 4, 9 Ichimura Y.... Kato T. (2004)
- Association between the GCG polymorphism of the selenium dependent GPX1 gene and the risk of young onset prostate cancer. (PubMed id 12496980)1, 2, 4, 9 Kote-Jarai Z.... Eeles R. (2002)
- Association between polymorphisms of the GPX1 gene and second primary tumours after index squamous cell cancer of the head and neck. (PubMed id 15878749)1, 4, 9 Jefferies S.... . (2005)
- Functional polymorphism of the glutathione peroxidase 1 gene is associated with personality traits in healthy subjects. (PubMed id 15990458)1, 4, 9 Matsuzawa D....Iyo M. (2005)
- Genetic variants of GPX1 and SOD2 and breast cancer risk at the Ontario site of the Breast Cancer Family Registry. (PubMed id 14744747)1, 4, 9 Knight J.A....Ozcelik H. (2004)
- Glutathione pathway genes and lung cancer risk in young and old populations. (PubMed id 15192016)1, 4, 9 Yang P....de Andrade M. (2004)
- Phenotype determination of a common Pro-Leu polymorphism in human glutathione peroxidase 1. (PubMed id 11112379)1, 4, 9 Forsberg L....Morgenstern R. (2000)
- Associations between GPX1 Pro198Leu polymorphism, erythrocyte GPX activity, alcohol consumption and breast cancer risk in a prospective cohort study. (PubMed id 16287877)1, 4, 9 Ravn-Haren G....Vogel U. (2006)
- Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway. (PubMed id 15829318)1, 4, 9 Skuladottir H....Olsen J.H. (2005)
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External Searches for GPX1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing GPX1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing GPX1 gene
(According to HUGE)
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Specialized Databases showing GPX1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for GPX1 | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for GPX1 | Genetics and Cytogenetics in Oncology and Haematology | | NIEHS-SNPs | http://egp.gs.washington.edu/data/gpx1/ | | Wikipedia | http://en.wikipedia.org/wiki/Glutathione_peroxidase |
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| Patent Information for GPX1 gene:
Search GeneIP for patents involving GPX1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for GPX1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for GPX1 | | OriGene shRNA RFP for GPX1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GPX1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPX1 | | | OriGene Protein Over-expression Lysate for GPX1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GPX1 | | OriGene 3'-UTR Clone for GPX1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPX1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPX1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GPX1 | | OriGene Custom Protein Services for GPX1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GPX1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPX1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPX1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPX1 |
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| | Antibodies & Assays for GPX1 |
| | | | Search Tocris compounds for GPX1 |
| |  |  |  |  | | | | | | Recombinant Protein for GPX1 |
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 | | | GPX1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibody for GPX1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPX1 |
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