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Aliases for GPX1 Gene

Aliases for GPX1 Gene

  • Glutathione Peroxidase 1 2 3 5
  • Cellular Glutathione Peroxidase 3 4
  • EC 1.11.1.9 4 58
  • GSHPx-1 3 4
  • EC 1.11.1 58
  • GSHPX1 3
  • GPx-1 4
  • GPXD 3

External Ids for GPX1 Gene

Previous GeneCards Identifiers for GPX1 Gene

  • GC03P048736
  • GC03P048542
  • GC03M049249
  • GC03M049353
  • GC03M049369
  • GC03M049360
  • GC03M049361
  • GC03M049362
  • GC03M049363
  • GC03M049365
  • GC03M049366

Summaries for GPX1 Gene

Entrez Gene Summary for GPX1 Gene

  • The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. This gene contains an in-frame GCG trinucleotide repeat in the coding region, and three alleles with 4, 5 or 6 repeats have been found in the human population. The allele with 4 GCG repeats has been significantly associated with breast cancer risk in premenopausal women. Alternatively spliced transcript variants have been found for this gene. Pseudogenes of this locus have been identified on chromosomes X and 21. [provided by RefSeq, Aug 2017]

GeneCards Summary for GPX1 Gene

GPX1 (Glutathione Peroxidase 1) is a Protein Coding gene. Diseases associated with GPX1 include Hemolytic Anemia Due To Glutathione Peroxidase Deficiency and Keshan Disease. Among its related pathways are Doxorubicin Pathway, Pharmacokinetics and Insulin secretion. GO annotations related to this gene include SH3 domain binding and selenium binding. An important paralog of this gene is GPX2.

UniProtKB/Swiss-Prot for GPX1 Gene

  • Protects the hemoglobin in erythrocytes from oxidative breakdown.

Gene Wiki entry for GPX1 Gene

Additional gene information for GPX1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPX1 Gene

Genomics for GPX1 Gene

Regulatory Elements for GPX1 Gene

Enhancers for GPX1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H049924 1.4 Ensembl ENCODE 4.7 -569.6 -569588 7 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 FOS RBM6 CDHR4 GPX1 SEMA3F-AS1 HYAL1 MON1A GC03P049904
GH03H049362 0.9 dbSUPER 0.7 -2.8 -2763 0 HDAC1 PKNOX1 ARNT CHAMP1 TCF12 ZNF766 GATA2 SMARCA5 NCOA1 ZEB2 GPX1 RHOA-IT1
GH03H049361 0.5 dbSUPER 0.7 -4.2 -4220 1 JUND ADNP FOS AMT GPX1 RHOA-IT1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPX1 on UCSC Golden Path with GeneCards custom track

Promoters for GPX1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000152207 900 1801 HDGF MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143

Genomic Location for GPX1 Gene

Chromosome:
3
Start:
49,357,176 bp from pter
End:
49,358,600 bp from pter
Size:
1,425 bases
Orientation:
Minus strand

Genomic View for GPX1 Gene

Genes around GPX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPX1 Gene

Proteins for GPX1 Gene

  • Protein details for GPX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07203-GPX1_HUMAN
    Recommended name:
    Glutathione peroxidase 1
    Protein Accession:
    P07203
    Secondary Accessions:
    • E9PAS1
    • Q7Z5H1
    • Q9BW12

    Protein attributes for GPX1 Gene

    Size:
    203 amino acids
    Molecular mass:
    22088 Da
    Quaternary structure:
    • Homotetramer. Interacts with MIEN1.

    Three dimensional structures from OCA and Proteopedia for GPX1 Gene

    Alternative splice isoforms for GPX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPX1 Gene

Selected DME Specific Peptides for GPX1 Gene

P07203:
  • EPDIEALL
  • WNFEKFL
  • YTQMNELQRRLG
  • WNFEKFLVG
  • LIENVASLUG
  • PVCRNDV
  • LMTDPKLI
  • FEKFLVGPDGVP
  • EVNGAGAH
  • LKYVRPGGGF
  • RRYSRRF
  • GGEPVSLG
  • LAAAAAQSVYAFSAR
  • NEEILNSLKYVR
  • LVVLGFPC
  • AWNFEKFL
  • FPCNQFG
  • AHPLFAFLRE

Post-translational modifications for GPX1 Gene

  • During periods of oxidative stress, Sec-49 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPX1 Gene

Antibody Products

  • R&D Systems Antibodies for GPX1 (Glutathione Peroxidase 1/GPX1)
  • Cell Signaling Technology (CST) Antibodies for GPX1 (GPX1)

Assay Products

  • Cloud-Clone Corp. Assay Kits for GPX1

Domains & Families for GPX1 Gene

Gene Families for GPX1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GPX1 Gene

Suggested Antigen Peptide Sequences for GPX1 Gene

Graphical View of Domain Structure for InterPro Entry

P07203

UniProtKB/Swiss-Prot:

GPX1_HUMAN :
  • Belongs to the glutathione peroxidase family.
Family:
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX1: view

Function for GPX1 Gene

Molecular function for GPX1 Gene

GENATLAS Biochemistry:
glutathione peroxidase 1,selenium dependent,cellular,catabolic pathway of activated oxygen species,free radical detoxification
UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
UniProtKB/Swiss-Prot Function:
Protects the hemoglobin in erythrocytes from oxidative breakdown.

Enzyme Numbers (IUBMB) for GPX1 Gene

Phenotypes From GWAS Catalog for GPX1 Gene

Gene Ontology (GO) - Molecular Function for GPX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity IEA --
GO:0004602 glutathione peroxidase activity IEA,TAS --
GO:0016491 oxidoreductase activity IEA --
GO:0017124 SH3 domain binding IPI 12893824
genes like me logo Genes that share ontologies with GPX1: view
genes like me logo Genes that share phenotypes with GPX1: view

Human Phenotype Ontology for GPX1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GPX1 Gene

MGI Knock Outs for GPX1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPX1
  • Applied Biological Materials Clones for GPX1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Transcription Factor Targets and HOMER Transcription for GPX1 Gene

Localization for GPX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPX1 gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 5
plasma membrane 2
peroxisome 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GPX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 10833429
GO:0005739 mitochondrion IDA 10833429
GO:0005759 mitochondrial matrix TAS --
GO:0005829 cytosol IDA,TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with GPX1: view

Pathways & Interactions for GPX1 Gene

genes like me logo Genes that share pathways with GPX1: view

SIGNOR curated interactions for GPX1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GPX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis IEA --
GO:0001885 endothelial cell development IEA --
GO:0002862 negative regulation of inflammatory response to antigenic stimulus IEA --
GO:0006195 purine nucleotide catabolic process TAS --
GO:0006629 lipid metabolic process IEA --
genes like me logo Genes that share ontologies with GPX1: view

Drugs & Compounds for GPX1 Gene

(30) Drugs for GPX1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target, Target, cofactor 0
Selenium Approved, Vet_approved Pharma 185
Hydrogen peroxide Approved, Vet_approved Pharma 68
Water Approved Pharma 0
Selenocysteine Experimental Pharma 0

(29) Additional Compounds for GPX1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15(S)-HETE
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoic acid
54845-95-3
15(S)-HPETE
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • 15-Hydroperoxyeicosatetraenoate
  • 15-Hydroperoxyeicosatetraenoic acid
  • 15-Hydroperoxyicosatetraenoate
70981-96-3
5(S)-Hydroperoxyeicosatetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
71774-08-8
5-HETE
  • 5(S)-HETE
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5(S)-Hydroxyeicosatetraenoate
  • 5(S)-Hydroxyeicosatetraenoic acid
70608-72-9
5-Hpete
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-HPETE
74581-83-2
genes like me logo Genes that share compounds with GPX1: view

Transcripts for GPX1 Gene

Unigene Clusters for GPX1 Gene

Glutathione peroxidase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GPX1
  • Applied Biological Materials Clones for GPX1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GPX1 Gene

No ASD Table

Relevant External Links for GPX1 Gene

GeneLoc Exon Structure for
GPX1
ECgene alternative splicing isoforms for
GPX1

Expression for GPX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPX1 Gene

This gene is overexpressed in Whole Blood (x6.8).

Protein differential expression in normal tissues from HIPED for GPX1 Gene

This gene is overexpressed in Nasal epithelium (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GPX1 Gene



Protein tissue co-expression partners for GPX1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPX1 Gene:

GPX1

SOURCE GeneReport for Unigene cluster for GPX1 Gene:

Hs.76686

Evidence on tissue expression from TISSUES for GPX1 Gene

  • Liver(4.8)
  • Kidney(4.6)
  • Skin(4.2)
  • Lung(4.1)
  • Nervous system(4.1)
  • Blood(3.3)
  • Stomach(3.2)
  • Eye(3.1)
  • Pancreas(3.1)
  • Intestine(3)
  • Heart(2.9)
  • Muscle(2.7)
  • Spleen(2.5)
  • Thyroid gland(2.3)
  • Adrenal gland(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for GPX1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • cardiovascular
  • integumentary
  • nervous
Organs:
Head and neck:
  • brain
  • head
General:
  • blood
  • red blood cell
  • skin
genes like me logo Genes that share expression patterns with GPX1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GPX1 Gene

Orthologs for GPX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPX1 34 33
  • 99.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPX1 34 33
  • 90.18 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gpx1 16 34 33
  • 86.23 (n)
cow
(Bos Taurus)
Mammalia GPX1 33
  • 85.99 (n)
rat
(Rattus norvegicus)
Mammalia Gpx1 33
  • 83.69 (n)
oppossum
(Monodelphis domestica)
Mammalia GPX1 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPX1 34 33
  • 74.68 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPX1 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpx1 33
  • 68.11 (n)
Str.9465 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.1906 33
zebrafish
(Danio rerio)
Actinopterygii gpx1a 34 33
  • 67.21 (n)
ManyToMany
wufd42f12 33
Species where no ortholog for GPX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPX1 Gene

ENSEMBL:
Gene Tree for GPX1 (if available)
TreeFam:
Gene Tree for GPX1 (if available)

Paralogs for GPX1 Gene

Paralogs for GPX1 Gene

(4) SIMAP similar genes for GPX1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for GPX1 Gene

genes like me logo Genes that share paralogs with GPX1: view

Variants for GPX1 Gene

Sequence variations from dbSNP and Humsavar for GPX1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1050450 Benign 49,357,401(-) AGGGC(C/T)CAGCT reference, missense, utr-variant-3-prime
rs1000444187 -- 49,358,421(+) CCGGC(C/T)CCCGC utr-variant-5-prime
rs1000612014 -- 49,358,259(+) CCGCC(G/T)CTAGC reference, missense
rs1000738694 -- 49,358,627(+) GAGTT(A/G)GGATG upstream-variant-2KB
rs1002388962 -- 49,358,119(+) GTCCC(A/G)GACCG intron-variant, reference, missense

Variation tolerance for GPX1 Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.57; 77.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPX1 Gene

Human Gene Mutation Database (HGMD)
GPX1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPX1 Gene

Disorders for GPX1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for GPX1 Gene - From: HGMD, OMIM, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hemolytic anemia due to glutathione peroxidase deficiency
  • glutathione peroxidase deficiency; gpxd
keshan disease
  • caused by deficiency of selenium in the diet
vulvar leiomyosarcoma
vulvar sarcoma
  • sarcoma of vulva
ileocolitis
  • iieocolitis
- elite association - COSMIC cancer census association via MalaCards
Search GPX1 in MalaCards View complete list of genes associated with diseases

Genatlas disease for GPX1 Gene

hemolytic anemia

Relevant External Links for GPX1

Genetic Association Database (GAD)
GPX1
Human Genome Epidemiology (HuGE) Navigator
GPX1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPX1
genes like me logo Genes that share disorders with GPX1: view

No data available for UniProtKB/Swiss-Prot for GPX1 Gene

Publications for GPX1 Gene

  1. Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in japanese type 2 diabetic patients. (PMID: 15331559) Hamanishi T … Nanjo K (Diabetes 2004) 3 4 22 45 60
  2. Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant. (PMID: 15247771) Ichimura Y … Kato T (The Journal of urology 2004) 3 4 22 45 60
  3. Association between the GCG polymorphism of the selenium dependent GPX1 gene and the risk of young onset prostate cancer. (PMID: 12496980) Kote-Jarai Z … CRC/BPG UK Familial Prostrate Cancer Collaborators (Prostate cancer and prostatic diseases 2002) 3 4 22 45 60
  4. Genetic variant of glutathione peroxidase 1 in autism. (PMID: 19195803) Ming X … Buyske S (Brain & development 2010) 3 22 45 60
  5. Missense polymorphisms in three oxidative-stress enzymes (GSTP1, SOD2, and GPX1) and dyskinesias in Russian psychiatric inpatients from Siberia. (PMID: 20041472) Al Hadithy AF … Loonen AJ (Human psychopharmacology 2010) 3 22 45 60

Products for GPX1 Gene

  • Addgene plasmids for GPX1

Sources for GPX1 Gene

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