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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPT2 Gene

protein-coding   GIFtS: 60
GCID: GC16P046918

glutamic pyruvate transaminase (alanine aminotransferase)...
 Explore 7 diseases affiliated with
GPT2 via
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Biological research products
for GPT2    

Aliases
for GPT2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Glutamic Pyruvate Transaminase (Alanine Aminotransferase) 21 2     GPT 22 3
ALT21 2 3 5     EC 2.6.1.23 8
Glutamate Pyruvate Transaminase 22 3     Alanine Aminotransferase 22
Glutamic--Alanine Transaminase 22 3     Glutamic-Pyruvate Transaminase 22
Glutamic--Pyruvic Transaminase 22 3     AAT23

External Ids:    HGNC: 180621   Entrez Gene: 847062   Ensembl: ENSG000001661237   OMIM: 1382105   UniProtKB: Q8TD303   

Export aliases for GPT2 gene to outside databases

Previous GC identifers: GC16P037329 GC16P046859 GC16P046658 GC16P046699 GC16P045475 GC16P032808


Summaries
for GPT2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GPT2:
This gene encodes one of the two pyridoxal enzymes which catalyze a reversible transamination reaction to yield
glutamate and pyruvate so these enzymes participate in amino acid metabolism and gluconeogenesis. Multiple transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: ALAT2_HUMAN, Q8TD30
Function: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate




Genomic Views
for GPT2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPT2 gene promoter:
         AREB6   NF-1   C/EBPbeta   SREBP-1a   ARP-1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GPT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for GPT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.1   Ensembl cytogenetic band:  16q11.2   HGNC cytogenetic band: 16q12.1

GPT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPT2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P046918:  view genomic region     (about GC identifiers)

Start:
 46,918,290 bp from pter      End:
 46,965,209 bp from pter
Size:
 46,920 bases      Orientation:
 plus strand

Proteins
for GPT2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ALAT2_HUMAN, Q8TD30 (See protein sequence)
Recommended Name: Alanine aminotransferase 2  
Size: 523 amino acids; 57904 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer (By similarity)
1 PDB 3D structure from and Proteopedia for GPT2:
3IHJ (3D)    
Secondary accessions: Q8N9E2
Alternative splicing: 2 isoforms:  Q8TD30-1   Q8TD30-2   

Explore the universe of human proteins at neXtProt for GPT2: NX_Q8TD30

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TD30

    • 4/12 DME Specific Peptides for GPT2 (Q8TD30) (see all 12)
     ELASFHS  SVRLCPP  YAVRGPIV  RILQACGG 

    GPT2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001135938.1  NP_597700.1  

    ENSEMBL proteins: 
     ENSP00000345282   ENSP00000457475   ENSP00000413804  
    Reactome Protein details: Q8TD30
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    Uscn Proteins for GPT2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005759mitochondrial matrix TAS--


    GPT2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for GPT2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GPT2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015422 PyrdxlP-dep_Trfase_major_sub2
     IPR004839 Aminotransferase_I/II
     IPR015424 PyrdxlP-dep_Trfase
     IPR015421 PyrdxlP-dep_Trfase_major_sub1

    Graphical View of Domain Structure for InterPro Entry Q8TD30

    ProtoNet protein and cluster: Q8TD30

    1 Blocks protein family: IPB004839 Aminotransferase

    UniProtKB/Swiss-Prot: ALAT2_HUMAN, Q8TD30
    Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase
    subfamily


    Function
    for GPT2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ALAT2_HUMAN, Q8TD30
    Function: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate
    Catalytic activity: L-alanine + 2-oxoglutarate = pyruvate + L-glutamate

    Enzyme Number (IUBMB): EC 2.6.1.21 2

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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004021L-alanine:2-oxoglutarate aminotransferase activity IDA11863375
    GO:0016740transferase activity ----
    GO:0030170pyridoxal phosphate binding IEA--


    GPT2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for GPT2:
     Increased number of cells in m 


    Pathways & Interactions
    for GPT2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    2Amino acid synthesis and interconversion (transamination)
    		Amino acid synthesis and interconversion (transamination)1.00
    3Metabolism of amino acids and derivatives
    		Metabolism of amino acids and derivatives1.00
    4Alanine, aspartate and glutamate metabolism
    		Alanine, aspartate and glutamate metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for GPT2
        Metabolism
    Amino acid synthesis and interconversion (transamination)
    Metabolism of amino acids and derivatives


    2         Kegg Pathways  (Kegg details for GPT2):
        Alanine, aspartate and glutamate metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: ALAT2_HUMAN, Q8TD30
    Pathway: Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1


    GPT2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GPT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/26 Interacting proteins for GPT2 (Q8TD303 ENSP000003452824) via UniProtKB, MINT, STRING, and/or I2D (see all 26)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    BABAM1Q9NWV83, ENSP000003524084I2D: score=2 STRING: ENSP00000352408
    USP20Q9Y2K63, ENSP000003138114I2D: score=2 STRING: ENSP00000313811
    PSAT1Q9Y6173, ENSP000003657734I2D: score=1 STRING: ENSP00000365773
    THNSL2Q86YJ63, ENSP000003273234I2D: score=1 STRING: ENSP00000327323
    USP7Q930093I2D: score=4 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00061032-oxoglutarate metabolic process IDA11863375
    GO:0008652cellular amino acid biosynthetic process TAS--
    GO:0009058biosynthetic process ----
    GO:0034641cellular nitrogen compound metabolic process TAS--
    GO:0042851L-alanine metabolic process IDA11863375


    GPT2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GPT2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GPT2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for GPT2

    6 HMDB Compounds for GPT2    About this table
    CompoundSynonyms CAS #PubMed Ids
    FamotidineAmfamox (see all 83)76824-35-6--
    L-Alanine(2S)-2-Aminopropanoate (see all 35)56-41-7--
    L-Glutamic acid(2S)-2-Aminopentanedioate (see all 49)56-86-0--
    Oxoglutaric acid2-Ketoglutarate (see all 9)328-50-7--
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--
    Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--

    4 DrugBank Compounds for GPT2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Alanine(2S)-2-Aminopropanoic acid (see all 15)56-41-7target--11863375 17139284 16495081 17016423 15122758
    Phenelzine-- 51-71-8targetinhibitor11775064 1881457 19203467
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor241701 17139284 17016423
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--17139284 17016423

    3 Novoseek chemical compound relationships for GPT2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alanine 69.6 5 11863375 (1), 18515302 (1), 12698502 (1), 15122758 (1)
    aspartate 29.8 1 12698502 (1)
    glucose 0 2 11863375 (1), 12698502 (1)

    Search CenterWatch for drugs/clinical trials and news about GPT2 / ALAT2 

    Transcripts
    for GPT2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GPT2 gene (2 alternative transcripts): 
    NM_001142466.1  NM_133443.2  

    Unigene Cluster for GPT2:

    Glutamic pyruvate transaminase (alanine aminotransferase) 2
    Hs.460693  [show with all ESTs]
    Unigene Representative Sequence: NM_133443
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340124(uc002eel.3) ENST00000562132 ENST00000440783(uc002eem.3)
    ENST00000562801 ENST00000569193(uc002een.3)

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    hsa-miR-3938 hsa-miR-30d hsa-miR-374a hsa-miR-301a hsa-miR-519a hsa-miR-766 hsa-miR-30a hsa-miR-3122
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK090957.1 AK094971.1 AL833351.1 AY029173.2 BC051364.1 BC062555.1 

    9 DOTS entries:

    DT.419329  DT.97818312  DT.100783490  DT.95077707  DT.120722391  DT.92435788  DT.95077656  DT.95306842 
    DT.95104528 

    24/228 AceView cDNA sequences (see all 228):

    BE504165 BQ011073 BQ649725 BM456416 BM671701 BQ422838 BE048491 AI799908 
    BE298184 BE327751 AI202436 AI393575 BQ651331 BF794537 BG740729 BC051364 
    CF132507 BQ083340 BQ649232 CB269036 CA425054 AA401242 AW732477 BQ068786 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GPT2 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
    SP1:                                                                    -                                                   
    SP2:              -     -     -                                                                                             
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                                                            -                           


    ECgene alternative splicing isoforms for GPT2

    Expression
    for GPT2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCTGAGGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GPT2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeVisceral White AdiposeAdipose
    BrainHypothalamusBrain
    BrainMedulla OblongataBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See GPT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GPT2

    SOURCE GeneReport for Unigene cluster: Hs.460693

    UniProtKB/Swiss-Prot: ALAT2_HUMAN, Q8TD30
    Tissue specificity: Expressed at high levels in muscle, adipose tissue, kidney and brain and at lower levels in the
    liver and breast

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    Orthologs
    for GPT2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for GPT2 gene from 10/36 species (see all 36)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GPT21 glutamic pyruvate transaminase (alanine aminotransferase) more 76.12(n)
    86.22(a)    		   415746  XM_414111.3  XP_414111.3 
    lizard
    (Anolis carolinensis)    		 Reptilia GPT26
    		 --
    		 89(a)
    		 1 ↔ 1
    		 LGc(3460129-3483331)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BU906297.12   -- 75.03(n)    BU906297.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufd46f012 Danio rerio cDNA clone IMAGE6791811, partial cds 75.79(n)    BC061955.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG16401 , 3 alanine aminotransferase3
    CG16401    		 55(a)3
    60.15(n)1
    55.46(a)1    		   11F13
    322921  NM_132651.21  NP_572879.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea CELE_C32F10.81 Protein C32F10.8 55.6(n)
    54.76(a)    		   172252  NM_001025850.3  NP_001021021.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes ALT1(YLR089C)4
    ALT21    		 Alanine transaminase (glutamic pyruvic transaminase); more4
    Alt2p1    		 50.96(n)1
    48.82(a)1    		   12(320015-318237)4
    8516901  NP_010396.11  8507784 
     NP_013190.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons GGT11 glutamate:glyoxylate aminotransferase 52.66(n)
    47.63(a)    		   838940  NM_102180.3  NP_564192.2 
    rice
    (Oryza sativa)    		 Liliopsida Os07g01083001 hypothetical protein 53.75(n)
    48.05(a)    		   4342210  NM_001065251.1  NP_001058716.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria malY6
    		 bifunctional beta-cystathionase, PLP-dependent/ re...
    		 14(a)
    		 possible ortholog
    		 Chromosome(1698981-1700153)


    ENSEMBL Gene Tree for GPT2 (if available)
    TreeFam Gene Tree for GPT2 (if available) 

    Paralogs
    for GPT2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GPT2 gene
    GPT2  
    1 SIMAP similar gene for GPT2 using alignment to 2 protein entries:     ALAT2_HUMAN (see all proteins):
    GPT

    GPT2 for paralogs           About GeneDecksing



    Genomic Variants
    for GPT2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/660 NCBI SNPs in GPT2 are shown (see all 660)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs49675941,2
    		C,F,A,H,--46916594(+) TGACAA/CGTGGG 1 -- us2k1 tfbs324Minor allele frequency- C:0.02NS EA NA WA CSA 1659
    rs1395150241,2
    		--46916611(+) GCAAGG/TGACTG 1 -- us2k10--------
    rs1496813881,2
    		--46916647(+) TCAAGC/TGTGTT 1 -- us2k10--------
    rs1914612271,2
    		--46916679(+) TGTGTC/TTCAAC 1 -- us2k10--------
    rs49667061,2
    		C,F,A,H,--46916727(+) AGCTCT/ACTGGG 1 -- us2k117Minor allele frequency- A:0.17NS EA NA WA CSA 796
    rs49675951,2
    		C,F,H,--46916747(+) TACCTG/AGAGAC 1 -- us2k117Minor allele frequency- A:0.02NS NA WA CSA EA 1166
    rs1150077341,2
    		--46916821(+) GCCCAA/GATAAC 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1462172061,2
    		--46916889(+) TCTTCG/TGTTTC 1 -- us2k10--------
    rs1390624121,2
    		--46917038(+) GTGCAC/TGGCTG 1 -- us2k10--------
    rs1854993921,2
    		--46917151(+) GCTCTG/TGGCTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for GPT2 (46918290 - 46965209 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for GPT2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPT2
    DNA2.0 Custom Variant and Variant Library Synthesis for GPT2

    Disorders / Diseases
    for GPT2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GPT2 for disorders           About GeneDecksing

    OMIM gene information: 138210    OMIM disorders: --

    7 diseases for GPT2:    About MalaCards
    kwashiorkor    elephantiasis    lymphangitis    filariasis
    hepatitis c    hepatitis    immunodeficiency

    1 Novoseek disease relationship for GPT2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    liver damage 67 2 19085960 (1)

    Human Genome Epidemiology (HuGE) Navigator: GPT2 (1 document)

    Export disorders for GPT2 gene to outside databases

    Publications
    for GPT2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GPT2 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with GPT2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase. (PubMed id 11863375)1, 2, 7, 9 Yang R.-Z.... Gong D.-W. (2002)
    2. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Murine alanine aminotransferase: cDNA cloning, functional expression, and differential gene regulation in mouse fatty liver. (PubMed id 15122758)7, 9 Jadhao S.B....Jadaho S.B. (2004)
    6. cDNA cloning, expression, purification, distribution, and characterization of biologically active canine alanine aminotransferase-1. (PubMed id 16495081)7, 9 Rajamohan F....Lawton M. (2006)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    10. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)

    External Searches for GPT2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GPT2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84706 HGNC: 18062 AceView: GPT2 Ensembl:ENSG00000166123 euGenes: HUgn84706
    ECgene: GPT2 Kegg: 84706 H-InvDB: GPT2

    Other Databases showing GPT2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GPT2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GPT2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for GPT2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GPT2 gene:
    Search GeneIP for patents involving GPT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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