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Aliases for GPT Gene

Aliases for GPT Gene

  • Glutamic-Pyruvate Transaminase (Alanine Aminotransferase) 2 3
  • Glutamate Pyruvate Transaminase 1 3 4
  • Glutamic--Alanine Transaminase 1 3 4
  • Glutamic--Pyruvic Transaminase 1 3 4
  • EC 2.6.1.2 4 63
  • GPT 1 3 4
  • AAT1 3 4
  • ALT1 3 4
  • GPT1 3 4
  • Glutamic-Alanine Transaminase 1 3

External Ids for GPT Gene

Previous GeneCards Identifiers for GPT Gene

  • GC08P143295
  • GC08P145766
  • GC08P145333
  • GC08P145733
  • GC08P145734
  • GC08P145699
  • GC08P145632
  • GC08P145700
  • GC08P140843
  • GC08P145728

Summaries for GPT Gene

Entrez Gene Summary for GPT Gene

  • This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]

GeneCards Summary for GPT Gene

GPT (Glutamic-Pyruvate Transaminase (Alanine Aminotransferase)) is a Protein Coding gene. Diseases associated with GPT include paraquat poisoning and tinea unguium. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include pyridoxal phosphate binding and L-alanine:2-oxoglutarate aminotransferase activity. An important paralog of this gene is GPT2.

UniProtKB/Swiss-Prot for GPT Gene

  • Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPT Gene

Genomics for GPT Gene

Regulatory Elements for GPT Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GPT Gene

Chromosome:
8
Start:
144,502,221 bp from pter
End:
144,507,174 bp from pter
Size:
4,954 bases
Orientation:
Plus strand

Genomic View for GPT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPT Gene

Proteins for GPT Gene

  • Protein details for GPT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24298-ALAT1_HUMAN
    Recommended name:
    Alanine aminotransferase 1
    Protein Accession:
    P24298
    Secondary Accessions:
    • B0YJ18
    • D3DWM7
    • P78398
    • Q93076

    Protein attributes for GPT Gene

    Size:
    496 amino acids
    Molecular mass:
    54637 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer

neXtProt entry for GPT Gene

Proteomics data for GPT Gene at MOPED

Post-translational modifications for GPT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPT Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for GPT Gene

Suggested Antigen Peptide Sequences for GPT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P24298

UniProtKB/Swiss-Prot:

ALAT1_HUMAN :
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
Family:
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
genes like me logo Genes that share domains with GPT: view

No data available for Gene Families for GPT Gene

Function for GPT Gene

Molecular function for GPT Gene

GENATLAS Biochemistry:
glutamic-pyruvate transaminase (alanine aminotransferase)
UniProtKB/Swiss-Prot CatalyticActivity:
L-alanine + 2-oxoglutarate = pyruvate + L-glutamate
UniProtKB/Swiss-Prot Function:
Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity).
UniProtKB/Swiss-Prot Induction:
By glucocorticoids

Enzyme Numbers (IUBMB) for GPT Gene

Gene Ontology (GO) - Molecular Function for GPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity NAS 1931970
GO:0030170 pyridoxal phosphate binding IEA --
genes like me logo Genes that share ontologies with GPT: view
genes like me logo Genes that share phenotypes with GPT: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPT

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPT Gene

Localization for GPT Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPT Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPT Gene COMPARTMENTS Subcellular localization image for GPT gene
Compartment Confidence
extracellular 5
cytosol 4
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for GPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GPT: view

Pathways & Interactions for GPT Gene

genes like me logo Genes that share pathways with GPT: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot P24298-ALAT1_HUMAN

  • Pathway: Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1

Interacting Proteins for GPT Gene

Gene Ontology (GO) - Biological Process for GPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008652 cellular amino acid biosynthetic process TAS --
GO:0009058 biosynthetic process --
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0042853 L-alanine catabolic process IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with GPT: view

No data available for SIGNOR curated interactions for GPT Gene

Drugs & Compounds for GPT Gene

(97) Drugs for GPT Gene - From: HMDB, DrugBank, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenelzine Approved Pharma Target, inhibitor 6
L-Alanine Approved Nutra Full agonist, Agonist, Target Glycine receptor agonist 0
Famotidine Approved Pharma Histamine H2-receptor antagonist 51
Pyruvic acid Approved Nutra 0
Acarbose Approved, Investigational Pharma Alpha-glucosidase inhibitor 79

(43) Additional Compounds for GPT Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Oxoglutaric acid
  • 2-Ketoglutarate
  • 2-Ketoglutaric acid
  • 2-Oxo-1,5-pentanedioate
  • 2-Oxo-1,5-pentanedioic acid
  • 2-Oxoglutarate
328-50-7
2,5-Oligoadenylate
5-Hydroxytryptophol
  • 5-HTOL
  • 5-Hydroxy-1H-indole-3-ethanol
  • 5-Hydroxy-1H-Indole-3-ethanol(9CI)
  • 5-Hydroxy-3-indole
  • 5-Hydroxy-3-indoleacetic acid
154-02-9
6 mercaptopurine
6-phosphogluconate
genes like me logo Genes that share compounds with GPT: view

Transcripts for GPT Gene

Unigene Clusters for GPT Gene

Glutamic-pyruvate transaminase (alanine aminotransferase):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPT

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPT Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - - -
SP2: - -
SP3: - - -
SP4:
SP5:

Relevant External Links for GPT Gene

GeneLoc Exon Structure for
GPT
ECgene alternative splicing isoforms for
GPT

Expression for GPT Gene

mRNA expression in normal human tissues for GPT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPT Gene

This gene is overexpressed in Liver (x14.3) and Colon - Transverse (x6.5).

Protein differential expression in normal tissues from HIPED for GPT Gene

This gene is overexpressed in Liver, secretome (20.8), Skin (12.2), and Liver (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPT Gene



SOURCE GeneReport for Unigene cluster for GPT Gene Hs.103502

mRNA Expression by UniProt/SwissProt for GPT Gene

P24298-ALAT1_HUMAN
Tissue specificity: Liver, kidney, heart, and skeletal muscles. Expressed at moderate levels in the adipose tissue.
genes like me logo Genes that share expression patterns with GPT: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for GPT Gene

Orthologs for GPT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPT 35
  • 86.69 (n)
  • 88.51 (a)
GPT 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPT 35
  • 87.09 (n)
  • 88.74 (a)
GPT 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpt 35
  • 83 (n)
  • 87.3 (a)
Gpt 16
Gpt 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPT 35
  • 99.06 (n)
  • 99.39 (a)
GPT 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpt 35
  • 84.14 (n)
  • 87.9 (a)
oppossum
(Monodelphis domestica)
Mammalia GPT 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPT 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 71 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gpt2 35
  • 70.46 (n)
  • 72.88 (a)
zebrafish
(Danio rerio)
Actinopterygii gpt2l 35
  • 68.33 (n)
  • 70.62 (a)
gpt2l 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1640 37
  • 53 (a)
CG1640 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C32F10.8 36
  • 54 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR085W 35
  • 51.15 (n)
  • 47.18 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALT2 35
  • 48.36 (n)
  • 47.77 (a)
ALT1 36
  • 37 (a)
ManyToMany
ALT2 36
  • 43 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons GGT1 35
  • 50.65 (n)
  • 46.98 (a)
rice
(Oryza sativa)
Liliopsida Os07g0108300 35
  • 51.68 (n)
  • 46.88 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
OneToMany
Species with no ortholog for GPT:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPT Gene

ENSEMBL:
Gene Tree for GPT (if available)
TreeFam:
Gene Tree for GPT (if available)

Paralogs for GPT Gene

Paralogs for GPT Gene

(1) SIMAP similar genes for GPT Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPT: view

Variants for GPT Gene

Sequence variations from dbSNP and Humsavar for GPT Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
VAR_000561 -

Structural Variations from Database of Genomic Variants (DGV) for GPT Gene

Variant ID Type Subtype PubMed ID
nsv470249 CNV Loss 18288195
nsv515809 CNV Gain+Loss 19592680
nsv891807 CNV Loss 21882294
nsv428208 CNV Gain 18775914
nsv891817 CNV Loss 21882294
dgv7959n71 CNV Loss 21882294
nsv891846 CNV Loss 21882294
nsv831489 CNV Loss 17160897
dgv7966n71 CNV Loss 21882294
dgv7968n71 CNV Loss 21882294
dgv7969n71 CNV Loss 21882294
dgv7972n71 CNV Loss 21882294
dgv907n27 CNV Loss 19166990
dgv7975n71 CNV Loss 21882294
dgv7976n71 CNV Loss 21882294
dgv7977n71 CNV Loss 21882294
dgv7978n71 CNV Loss 21882294
nsv891897 CNV Loss 21882294
esv29999 CNV Loss 17803354
nsv891911 CNV Loss 21882294
nsv891912 CNV Loss 21882294
dgv7981n71 CNV Loss 21882294
dgv7982n71 CNV Loss 21882294
dgv7983n71 CNV Loss 21882294
dgv1207n67 CNV Gain 20364138
dgv7984n71 CNV Loss 21882294
nsv824810 CNV Loss 20364138

Variation tolerance for GPT Gene

Residual Variation Intolerance Score: 60.21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.61; 86.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPT Gene

HapMap Linkage Disequilibrium report
GPT
Human Gene Mutation Database (HGMD)
GPT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPT Gene

Disorders for GPT Gene

MalaCards: The human disease database

(60) MalaCards diseases for GPT Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
paraquat poisoning
tinea unguium
  • cellulitis and abscess of upper arm and forearm
choledocholithiasis
scrub typhus
  • tsutsugamushi disease
acute liver failure
  • liver failure acute
- elite association
Search GPT in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPT

Genetic Association Database (GAD)
GPT
Human Genome Epidemiology (HuGE) Navigator
GPT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPT
genes like me logo Genes that share disorders with GPT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPT Gene

Publications for GPT Gene

  1. Determination of the activities of glutamic oxaloacetic transaminase and glutamic pyruvic transaminase in a microfluidic system. (PMID: 16854580) Ohgami N. … Suzuki H. (Biosens Bioelectron 2007) 23 25 26 67
  2. Combining markers of nephrotoxicity and hepatotoxicity for improved monitoring and detection of chronic alcohol abuse. (PMID: 17163821) Taracha E. … PA8aA_nik A. (Clin. Chem. Lab. Med. 2006) 25 26 67
  3. Case-control study of multiple chemical sensitivity, comparing haematology, biochemistry, vitamins and serum volatile organic compound measures. (PMID: 15347780) Baines C.J. … Jazmaji V. (Occup Med (Lond) 2004) 23 25 67
  4. Interaction between pyridoxal kinase and pyridoxal-5-phosphate-dependent enzymes. (PMID: 14688239) Cheung P.Y. … Wong M.S. (J. Biochem. 2003) 23 25 67
  5. Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study. (PMID: 19297346) Jones G. … Genovese M.C. (Ann. Rheum. Dis. 2010) 23 67

Products for GPT Gene

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