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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPT Gene

protein-coding   GIFtS: 65
GCID: GC08P145728

Glutamic-Pyruvate Transaminase (Alanine Aminotransferase)

Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Glutamic-Pyruvate Transaminase (Alanine Aminotransferase)1 2     ALT12 3
AAT12 3 5     GPT 12 3
GPT12 3 5     EC 2.6.1.23 8
Glutamate Pyruvate Transaminase 12 3     Alanine Aminotransferase 12
Glutamic--Alanine Transaminase 12 3     Glutamic-Alanine Transaminase 12
Glutamic--Pyruvic Transaminase 12 3     

External Ids:    HGNC: 45521   Entrez Gene: 28752   Ensembl: ENSG000001677017   OMIM: 1382005   UniProtKB: P242983   

Export aliases for GPT gene to outside databases

Previous GC identifers: GC08P143295 GC08P145766 GC08P145333 GC08P145733 GC08P145734 GC08P145699 GC08P145632 GC08P145700 GC08P140843


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GPT Gene:
This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1.
This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and
glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum
activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity,
infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine
aminotransaminase.(provided by RefSeq, Nov 2009)

GeneCards Summary for GPT Gene: 
GPT (glutamic-pyruvate transaminase (alanine aminotransferase)) is a protein-coding gene. Diseases associated with GPT include typhus, and paraquat poisoning, and among its related super-pathways are Metabolic pathways and alanine biosynthesis II. GO annotations related to this gene include pyridoxal phosphate binding and L-alanine:2-oxoglutarate aminotransferase activity. An important paralog of this gene is GPT2.

UniProtKB/Swiss-Prot: ALAT1_HUMAN, P24298
Function: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and
glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with
precursors transported from skeletal muscles (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_037704.5  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPT gene promoter:
         Sp1   p53   COUP   Nkx2-5   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPT promoter sequence
   Search SABiosciences Chromatin IP Primers for GPT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

GPT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPT gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P145728:  view genomic region     (about GC identifiers)

Start:
145,728,356 bp from pter      End:
145,732,557 bp from pter
Size:
4,202 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ALAT1_HUMAN, P24298 (See protein sequence)
Recommended Name: Alanine aminotransferase 1  
Size: 496 amino acids; 54637 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer
Subcellular location: Cytoplasm
Secondary accessions: B0YJ18 D3DWM7 P78398 Q93076

Explore the universe of human proteins at neXtProt for GPT: NX_P24298

Explore proteomics data for GPT at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P24298

  • 4/13 DME Specific Peptides for GPT (P24298) (see all 13)
     ELASFHS  SVRLCPP  YAVRGPIV  RILQACGG 

    GPT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GPT Protein Expression
    REFSEQ proteins: NP_005300.1  
    ENSEMBL proteins: 
     ENSP00000433586   ENSP00000378408  
    Reactome Protein details: P24298
    Human Recombinant Protein Products for GPT: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS--
    GO:0005829cytosol TAS--

    GPT for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR015422 PyrdxlP-dep_Trfase_major_sub2
     IPR004839 Aminotransferase_I/II
     IPR015424 PyrdxlP-dep_Trfase
     IPR015421 PyrdxlP-dep_Trfase_major_sub1

    Graphical View of Domain Structure for InterPro Entry P24298

    ProtoNet protein and cluster: P24298

    2 Blocks protein domains:
    IPB001176 1-aminocyclopropane-1-carboxylate synthase signature
    IPB004839 Aminotransferase


    UniProtKB/Swiss-Prot: ALAT1_HUMAN, P24298
    Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase
    subfamily


    GPT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALAT1_HUMAN, P24298
    Function: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and
    glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with
    precursors transported from skeletal muscles (By similarity)
    Catalytic activity: L-alanine + 2-oxoglutarate = pyruvate + L-glutamate
    Induction: By glucocorticoids

         Genatlas biochemistry entry for GPT:
    glutamic-pyruvate transaminase (alanine aminotransferase)

         Enzyme Number (IUBMB): EC 2.6.1.21 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004021L-alanine:2-oxoglutarate aminotransferase activity NAS1931970
    GO:0030170pyridoxal phosphate binding IEA--
         
    GPT for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GPT About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    2alanine degradation III
    alanine degradation III1.00
    alanine biosynthesis II1.00
    3Carbon metabolism
    Biosynthesis of amino acids0.37
    4Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    5Amino acid synthesis and interconversion (transamination)
    Amino acid synthesis and interconversion (transamination)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for GPT
        Alanine and aspartate metabolism
    alanine degradation III
    alanine biosynthesis II


    3        Reactome Pathways for GPT
        Metabolism
    Amino acid synthesis and interconversion (transamination)
    Metabolism of amino acids and derivatives


    4         Kegg Pathways  (Kegg details for GPT):
        Alanine, aspartate and glutamate metabolism
    Metabolic pathways
    2-Oxocarboxylic acid metabolism
    Biosynthesis of amino acids

    UniProtKB/Swiss-Prot: ALAT1_HUMAN, P24298
    Pathway: Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1


    GPT for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for GPT (P242983 ENSP000003784084) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAPN1P073843, ENSP000002792474I2D: score=3 STRING: ENSP00000279247
    CAPN3ENSP000003803494STRING: ENSP00000380349
    CDC7ENSP000002346264STRING: ENSP00000234626
    THNSL2ENSP000003273234STRING: ENSP00000327323
    HSPD1ENSP000003400194STRING: ENSP00000340019
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006094gluconeogenesis NAS--
    GO:0006807nitrogen compound metabolic process NAS--
    GO:0008652cellular amino acid biosynthetic process TAS--
    GO:0009058biosynthetic process ----
    GO:0034641cellular nitrogen compound metabolic process TAS--

    GPT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GPT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GPT (ALAT1)

    6 HMDB Compounds for GPT    About this table
    CompoundSynonyms CAS #PubMed Ids
    FamotidineAmfamox (see all 83)76824-35-6--
    L-Alanine(2S)-2-Aminopropanoate (see all 35)56-41-7--
    L-Glutamic acid(2S)-2-Aminopentanedioate (see all 49)56-86-0--
    Oxoglutaric acid2-Ketoglutarate (see all 9)328-50-7--
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--
    Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--

    4 DrugBank Compounds for GPT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor11330835 12537583 15347780 14688239 16179747
    L-Alanine(2S)-2-Aminopropanoic acid (see all 15)56-41-7target--17353078 17163821 17319845 17403374
    Phenelzine-- 51-71-8targetinhibitor11775064 1881457 19203467
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--16854580

    10/133 Novoseek inferred chemical compound relationships for GPT gene (see all 133)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alanine 98.5 5513 17058711 (6), 9551672 (5), 8831054 (5), 8740843 (5) (see all 99)
    aspartate 96.2 2037 8831054 (5), 18339592 (5), 16917217 (4), 1352485 (4) (see all 99)
    lamivudine 86.9 82 18931274 (2), 18094378 (2), 16393286 (2), 16525138 (2) (see all 68)
    entecavir 81.7 19 16525138 (2), 20028815 (2), 19053898 (1), 16525137 (1) (see all 14)
    adefovir 80.4 23 12606735 (2), 17321635 (2), 18771054 (1), 18367858 (1) (see all 17)
    creatinine 78.7 589 17938134 (4), 12241024 (3), 19084848 (3), 9526816 (3) (see all 99)
    ribavirin 76.3 36 7865717 (2), 10342322 (2), 17971091 (2), 17412448 (2) (see all 27)
    telbivudine 73.7 10 18094378 (2), 20028815 (2), 19408969 (1), 19225726 (1) (see all 6)
    ursodeoxycholic acid 72.3 37 8808432 (1), 9641646 (1), 10680665 (1), 17763401 (1) (see all 33)
    lactate 71.2 339 12241024 (3), 20017420 (3), 2205108 (2), 11601675 (2) (see all 99)

    Search CenterWatch for drugs/clinical trials and news about GPT / ALAT1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for GPT gene: 
    NM_005309.2  

    Unigene Cluster for GPT:

    Glutamic-pyruvate transaminase (alanine aminotransferase)
    Hs.103502  [show with all ESTs]
    Unigene Representative Sequence: NM_005309
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528431 ENST00000527165(uc011llj.1) ENST00000531330 ENST00000354769
    ENST00000534702 ENST00000527961 ENST00000394955(uc003zdh.4)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK225562.1 BC018207.1 BT006992.1 D10355.1 

    5 DOTS entries:

    DT.121491846  DT.108879  DT.95368785  DT.87046215  DT.91806472 

    24/30 AceView cDNA sequences (see all 30):

    AW001265 BC018207 CB266898 BI820187 AI283141 R49523 NM_005309 AI016602 
    BT006992 BG697397 BG741866 BG698409 AU076466 BP342813 D10355 BP334517 
    BG740047 BF529332 AW242645 AA862992 BE267022 AI271988 AI935397 BP381463 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for GPT    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:        -     -     -                 -                 -                                                         
    SP2:                                      -                 -                                                         
    SP3:                                      -     -           -                                                         
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for GPT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPT expression in normal human tissues (normalized intensities)      GPT embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAGTTCAC
    GPT Expression
    About this image


    GPT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Thalamus
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             Immature hepatocytes ( Functional, immature hepatocyte differentiation from human...
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Kidney (Urinary System)
             kidney ; cells in tubules   

    See GPT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GPT

    SOURCE GeneReport for Unigene cluster: Hs.103502

    UniProtKB/Swiss-Prot: ALAT1_HUMAN, P24298
    Tissue specificity: Liver, kidney, heart, and skeletal muscles. Expressed at moderate levels in the adipose tissue

        SABiosciences Expression via Pathway-Focused PCR Arrays including GPT: 
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GPT gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpt1 , 5 glutamic pyruvic transaminase, soluble1, 5 83(n)1
    87.3(a)1
      15 (36.28 cM)5
    762821  NM_182805.21  NP_877957.11 
     766967645 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    71(a)
    70(a)
    many → 1
    many → 1
    AAWZ02036629(2465-23878)
    GL343750.1(4321-26696)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL883531.22   -- 74.8(n)    AL883531.2 
    zebrafish
    (Danio rerio)
    Actinopterygii gpt2l1 glutamic pyruvate transaminase (alanine aminotransferase) more 68.33(n)
    70.62(a)
      403086  NM_001142774.1  NP_001136246.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG16403 alanine aminotransferase 53(a)   11F1   --
    worm
    (Caenorhabditis elegans)
    Secernentea C32F10.86
    Protein C32F10.8, isoform a
    54(a)
    1 → many
    I(5822841-5826155)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ALT11 Alt1p 46.91(n)
    46.91(a)
      850778   NP_013190.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ALAAT21 alanine aminotransferase 2 51(n)
    49.36(a)
      843565  NM_105892.4  NP_565040.2 
    rice
    (Oryza sativa)
    Liliopsida Os10g03905001 hypothetical protein 50.53(n)
    46.95(a)
      4348524  NM_001071039.1  NP_001064504.1 


    ENSEMBL Gene Tree for GPT (if available)
    TreeFam Gene Tree for GPT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GPT gene
    GPT22  
    1 SIMAP similar gene for GPT using alignment to 1 protein entry:     ALAT1_HUMAN:
    GPT2

    GPT for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/229 SNPs in GPT are shown (see all 229)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10637391,2,4
    C,F,A,Hnon-pathogenic1146002486(+) TGAGGA/C/GATGGA 2 H D mis1 ese325MN NS EA NA CSA WA EU 7995
    rs1845071751,2
    --146000307(+) CCCACA/GGTGGG 1 -- us2k10--------
    rs1893935851,2
    --146000368(+) AAGCCC/TGTAGG 1 -- us2k10--------
    rs27211971,2
    C,F,A,H--146000464(-) GAGCAT/CGGGAG 1 -- us2k123Minor allele frequency- C:0.37NS EA NA WA 2562
    rs1157002651,2
    C,F--146000655(+) AGAGGG/AGCAAA 1 -- us2k11Minor allele frequency- A:0.15WA 118
    rs1822269761,2
    --146000672(+) ACAAGC/GCTGTG 1 -- us2k10--------
    rs454928951,2
    C,F--146000897(+) GTGGGC/TGGCTT 1 -- us2k11Minor allele frequency- T:0.05NS 38
    rs1436415151,2
    --146000946(+) GTTCTC/TCCTCC 1 -- us2k10--------
    rs1891102091,2
    --146000969(+) GGCCCA/GTCAGC 1 -- us2k10--------
    rs1439427221,2
    C--146001077(+) AGTGT-/GGGGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GPT (145728356 - 145732557 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/27 variations for GPT (see all 27):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv907n27CNV Loss19166990
    dgv7966n71CNV Loss21882294
    dgv7977n71CNV Loss21882294
    dgv7976n71CNV Loss21882294
    dgv7978n71CNV Loss21882294
    dgv7983n71CNV Loss21882294
    dgv7982n71CNV Loss21882294
    nsv891911CNV Loss21882294
    nsv891846CNV Loss21882294
    nsv891817CNV Loss21882294


    Human Gene Mutation Database (HGMD): GPT
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GPT
    DNA2.0 Custom Variant and Variant Library Synthesis for GPT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 138200    OMIM disorders: --

    20/270 diseases for GPT (see all 270):    About MalaCards
    typhus    paraquat poisoning    hemorrhagic shock and encephalopathy syndrome    tinea unguium
    epidemic typhus    kidney cortex necrosis    pyomyositis    fatty liver disease
    viral hepatitis    hepatitis a    nonalcoholic steatohepatitis    hepatitis e
    hemorrhagic fever    choledocholithiasis    non-a-e hepatitis    afferent loop syndrome
    coronary aneurysm    bile duct disease    liver cirrhosis    alcohol abuse

    1 disease from the University of Copenhagen DISEASES database for GPT:
    Vitelliform macular dystrophy

    GPT for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/98 Novoseek inferred disease relationships for GPT gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis b chronic 92 78 16042881 (2), 19585616 (2), 19032864 (2), 12828081 (2) (see all 59)
    hepatitis c chronic 89.7 95 16487620 (4), 15921043 (2), 10773739 (2), 9641644 (2) (see all 83)
    hepatitis b 89.6 350 20028815 (3), 8243482 (2), 10192613 (2), 12584227 (2) (see all 99)
    hepatitis c 89.5 203 12870728 (3), 8243482 (2), 11426070 (2), 16460486 (2) (see all 99)
    liver diseases 88.7 141 10500955 (2), 18763311 (2), 17272484 (2), 15810122 (2) (see all 99)
    fatty liver 87.3 103 16917217 (3), 7643460 (2), 18763311 (2), 17272484 (2) (see all 84)
    hepatitis 86.7 148 17639161 (2), 8803450 (2), 15462195 (2), 8158817 (2) (see all 99)
    liver damage 84.8 50 7516951 (2), 8395606 (1), 17591075 (1), 12430760 (1) (see all 42)
    hepatitis chronic 83.6 33 11895556 (1), 10336003 (1), 10342322 (1), 2132352 (1) (see all 32)
    cirrhosis 82.4 73 9443106 (2), 18339592 (2), 7845310 (1), 9118030 (1) (see all 62)

    Genetic Association Database (GAD): GPT
    Human Genome Epidemiology (HuGE) Navigator: GPT (70 documents)

    Export disorders for GPT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GPT gene, integrated from 9 sources (see all 2476):
    (articles sorted by number of sources associating them with GPT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human glutamate pyruvate transaminase (GPT): localization to 8q24.3, cDNA and genomic sequences, and polymorphic sites. (PubMed id 9119391)1, 2, 9 Sohocki M.M.... Daiger S.P. (1997)
    2. cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase. (PubMed id 11863375)1, 2, 9 Yang R.-Z.... Gong D.-W. (2002)
    3. Complete amino acid sequence of human liver cytosolic alanine aminotransferase (GPT) determined by a combination of conventional and mass spectral methods. (PubMed id 1931970)1, 2, 9 Ishiguro M.... Titani K. (1991)
    4. Typing classical polymorphisms by real-time PCR: Analysis of the GPT and ALAD protein polymorphisms in the Jewish populations. (PubMed id 18432999)1, 4, 9 Zoossmann-Diskin A....Turner D. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Usefulness of GPT for diagnosis of metabolic syndrome in obese Japanese children. (PubMed id 20032584)1, 9 Abe Y....Uchiyama M. (2009)
    7. Expression, purification, and initial characterization of human alanine aminotransferase (ALT) isoenzyme 1 and 2 in High-five insect cells. (PubMed id 18508279)1, 9 Liu L....Gong D.W. (2008)
    8. Determination of the activities of glutamic oxaloacet ic transaminase and glutamic pyruvic transaminase in a microfluidic system. (PubMed id 16854580)7, 9 Ohgami N....Suzuki H. (2007)
    9. A better parameter in predicting insulin resistance: obesity plus elevated alanine aminotransferase. (PubMed id 19938201)1, 9 Chen P.H....Lin Y.C. (2009)
    10. Relationship between alanine aminotransferase levels and metabolic syndrome in nonalcoholic fatty liver disease. (PubMed id 18763311)1, 9 Chen Z.W....Fang L.Z. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2875 HGNC: 4552 AceView: GPT Ensembl:ENSG00000167701 euGenes: HUgn2875
    ECgene: GPT Kegg: 2875 H-InvDB: GPT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GPT Pharmacogenomics, SNPs, Pathways
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=GPT
    Wikipedia http://en.wikipedia.org/wiki/Alanine_transaminase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GPT gene:
    Search GeneIP for patents involving GPT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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