Aliases for GPT Gene
External Ids for GPT Gene
Previous GeneCards Identifiers for GPT Gene
This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]
GeneCards Summary for GPT Gene
GPT (Glutamic-Pyruvate Transaminase (Alanine Aminotransferase)) is a Protein Coding gene. Diseases associated with GPT include Hepatitis and Choledocholithiasis. Among its related pathways are Alanine and aspartate metabolism and Amino acid synthesis and interconversion (transamination). GO annotations related to this gene include pyridoxal phosphate binding and L-alanine:2-oxoglutarate aminotransferase activity. An important paralog of this gene is GPT2.
UniProtKB/Swiss-Prot for GPT Gene
Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity).