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GPSM3 Gene

protein-coding   GIFtS: 47
GCID: GC06M032165

G-Protein Signaling Modulator 3

(Previous names: chromosome 6 open reading frame 9, G-protein signalling...)
(Previous symbol: C6orf9)
  Search for GPSM3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
G-Protein Signaling Modulator 31 2     Chromosome 6 Open Reading Frame 91
C6orf91 2 3     G18.1a2
Activator Of G-Protein Signaling 41 2 3     G18.22
G-Protein Signalling Modulator 3 (AGS3-Like, C. Elegans)1 2     NG12
AGS42 3     G-Protein Signaling Modulator 3 (AGS3-Like, C. Elegans)2
G182 3     G-Protein-Signaling Modulator 32
G18.1b2 3     Protein G183

External Ids:    HGNC: 139451   Entrez Gene: 639402   Ensembl: ENSG000002136547   UniProtKB: Q9Y4H43   

Export aliases for GPSM3 gene to outside databases

Previous GC identifers: GC06M032229 GC06M032266 GC06M031912


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GPSM3 Gene:
GPSM3 (G-protein signaling modulator 3) is a protein-coding gene. GO annotations related to this gene include GDP-dissociation inhibitor activity.

UniProtKB/Swiss-Prot: GPSM3_HUMAN, Q9Y4H4
Function: Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  NT_113891.3  NT_167244.2  NT_167246.2  NT_167247.2  NT_167248.2  
NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPSM3 gene promoter:
         HEN1   CREB   Pax-5   deltaCREB   STAT3   ITF-2   Tal-1beta   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for GPSM3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPSM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

GPSM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPSM3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M032165:  view genomic region     (about GC identifiers)

Start:
32,158,543 bp from pter      End:
32,163,300 bp from pter
Size:
4,758 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_167244 3,473,281-3,478,038      Chr6-,NT_167249 3,506,269-3,511,026      Chr6-,NT_167248 3,419,561-3,424,318     
Chr6-,NT_167246 3,501,364-3,506,121      Chr6-,NT_167247 3,538,367-3,543,124      Chr6-,NT_113891.2 3,629,221-3,633,978     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GPSM3_HUMAN, Q9Y4H4 (See protein sequence)
Recommended Name: G-protein-signaling modulator 3  
Size: 160 amino acids; 17866 Da
Secondary accessions: A2BFJ3

Explore the universe of human proteins at neXtProt for GPSM3: NX_Q9Y4H4

Explore proteomics data for GPSM3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GPSM3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_071390.1  NP_001263430.1  

    ENSEMBL proteins: 
     ENSP00000436358   ENSP00000432714   ENSP00000364180   ENSP00000364183  

    GPSM3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for GPSM3
    OriGene Protein Over-expression Lysate for GPSM3
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    Novus Biologicals GPSM3 Protein
    Novus Biologicals GPSM3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GPSM3

     
    Search eBioscience for Proteins for GPSM3 

    GPSM3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for GPSM3
    Cloud-Clone Corp. Antibodies for GPSM3
    ThermoFisher Antibodies for GPSM3
    Search LSBio for Antibodies for GPSM3

    GPSM3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GPSM3
    Cloud-Clone Corp. CLIAs for GPSM3
    Search eBioscience for ELISAs for GPSM3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003109 GoLoco_motif
     IPR024800 G_prot_signal_mod_3

    Graphical View of Domain Structure for InterPro Entry Q9Y4H4

    ProtoNet protein and cluster: Q9Y4H4

    UniProtKB/Swiss-Prot: GPSM3_HUMAN, Q9Y4H4
    Domain: The GoLoco 1 and/or GoLoco 3 domains exhibit GDI activity towards GDP-bound G(i) alpha protein, but not
    the GoLoco 2 domain
    Similarity: Contains 3 GoLoco domains


    Find genes that share domains with GPSM3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPSM3_HUMAN, Q9Y4H4
    Function: Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005092GDP-dissociation inhibitor activity ----
    GO:0030695GTPase regulator activity IEA--
         
    Find genes that share ontologies with GPSM3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GPSM3:
     Decreased cell number, increas 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gpsm3):
     cellular  hematopoietic system  immune system  skeleton 

    Find genes that share phenotypes with GPSM3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GPSM3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GPSM3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GPSM3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GPSM3

    miRNA
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    Block miRNA regulation of human, mouse, rat GPSM3 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate GPSM3:
    hsa-miR-1233 hsa-miR-525-5p hsa-miR-593 hsa-miR-1324 hsa-miR-520a-5p hsa-miR-1224-5p hsa-miR-3616-3p
    SwitchGear 3'UTR luciferase reporter plasmidGPSM3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for GPSM3
    Predesigned siRNA for gene silencing in human, mouse, rat GPSM3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: GPSM3 (NM_022107)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPSM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPSM3

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPSM3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GPSM3_HUMAN, Q9Y4H4: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    extracellular2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with GPSM3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GPSM3
    Interactions:

        Search GeneGlobe Interaction Network for GPSM3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for GPSM3 (Q9Y4H42, 3 ENSP000003641804) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR3P226072, 3, ENSP000002607954MINT-62616 MINT-62790 MINT-62714 I2D: score=4 STRING: ENSP00000260795
    GNAI1P630963, ENSP000003430274I2D: score=2 STRING: ENSP00000343027
    SVILO954253, ENSP000003481284I2D: score=1 STRING: ENSP00000348128
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway ----

    Find genes that share ontologies with GPSM3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPSM3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GPSM3 gene (2 alternative transcripts): 
    NM_022107.1  NM_001276501.1  

    Unigene Cluster for GPSM3:

    G-protein signaling modulator 3
    Hs.520046  [show with all ESTs]
    Unigene Representative Sequence: NM_001276501
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487761 ENST00000472768 ENST00000375040(uc003oay.4) ENST00000375043(uc003oaz.3)

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate GPSM3:
    hsa-miR-1233 hsa-miR-525-5p hsa-miR-593 hsa-miR-1324 hsa-miR-520a-5p hsa-miR-1224-5p hsa-miR-3616-3p
    SwitchGear 3'UTR luciferase reporter plasmidGPSM3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for GPSM3
    Predesigned siRNA for gene silencing in human, mouse, rat GPSM3
    Clone
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    OriGene clones in human, mouse for GPSM3 (see all 7)
    OriGene ORF clones in mouse, rat for GPSM3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GPSM3 (NM_022107)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPSM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPSM3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GPSM3
    OriGene qSTAR qPCR primer pairs in human, mouse for GPSM3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GPSM3
      QuantiTect SYBR Green Assays in human, mouse, rat GPSM3
      Search QuantiFast Probe-based Assays in human, mouse, rat GPSM3

    Additional mRNA sequence: 

    AF155657.1 AJ243937.1 AJ243938.1 AK313922.1 BC018724.1 

    9 DOTS entries:

    DT.40106718  DT.100768197  DT.97861850  DT.86846834  DT.308880  DT.121378203  DT.102839413  DT.86846833 
    DT.95083137 

    Selected AceView cDNA sequences (see all 222):

    AA984885 BQ057520 BQ023880 BM705319 BP340382 AW572963 BQ447238 BU855923 
    BU163550 AJ705578 BU580994 AI093309 BQ933211 AA868548 BQ711693 AI673445 
    BM352627 CK821917 AI355714 CR623296 BM811035 BG490215 CR604341 BQ011648 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPSM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGCTTGAG
    GPSM3 Expression
    About this image


    GPSM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Negative 2 Thymocytes Thymus
             Thymus
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Spleen (Hematopoietic System)
    GPSM3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPSM3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.520046

    UniProtKB/Swiss-Prot: GPSM3_HUMAN, Q9Y4H4
    Tissue specificity: Expressed in heart, placenta, lung and liver

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPSM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GPSM3 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpsm31 , 5 G-protein signalling modulator 3 (AGS3-like, C. elegans)1, 5 86.58(n)1
    88.68(a)1
      17 (18.17 cM)5
    1065121  NM_134116.51  NP_598877.11 
     345898065 
    lizard
    (Anolis carolinensis)
    Reptilia GPSM36
    G-protein signaling modulator 3
    46(a)
    1 ↔ 1
    2(198788406-198804680)
    zebrafish
    (Danio rerio)
    Actinopterygii GPSM36
    G-protein signaling modulator 3
    14(a)
    1 ↔ 1
    16(51935066-51947619) ENSDARG00000086246


    ENSEMBL Gene Tree for GPSM3 (if available)
    TreeFam Gene Tree for GPSM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GPSM3 (see all 42)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2002902431,2
    --32159999(+) GAGGGG/TGCCAG 4 H P mis10--------
    rs2002744201,2
    --32160011(+) CTTCCG/TCATCC 4 E A mis10--------
    rs22694201,2
    C,F,H--32160153(-) GAAAGG/TCTTGG 2 -- int15Minor allele frequency- T:0.05NS EA 536
    rs1883507951,2
    --32160355(+) ACCTTC/GGGTTC 2 -- int1 ut510--------
    rs1922476041,2
    --32160438(+) GGGTTC/TCTGGT 2 -- int1 ut510--------
    rs1160673941,2
    F--32160448(+) TCAGCC/GCCCCC 2 -- int1 ut511Minor allele frequency- G:0.01WA 118
    rs95016051,2
    C,F,H--32160524(+) CTCTCG/ACCCCA 2 -- int1 ut5110Minor allele frequency- A:0.02NS EA WA 1298
    rs1409792261,2
    C--32160658(+) CCCTCC/TACCCC 2 -- int1 ut510--------
    rs1831631941,2
    --32160735(+) AATCCC/TCCTCC 2 -- int1 us2k10--------
    rs1455459631,2
    C--32160762(+) TCCCT-/CCCTAA 2 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for GPSM3 (32158543 - 32163300 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for GPSM3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv6643n71CNV Loss21882294
    nsv884712CNV Loss21882294
    dgv6645n71CNV Loss21882294
    nsv830629CNV Loss17160897
    dgv6644n71CNV Loss21882294
    nsv884715CNV Loss21882294
    nsv462877CNV Loss19166990
    dgv1929e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPSM3
    DNA2.0 Custom Variant and Variant Library Synthesis for GPSM3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with GPSM3           About GenesLikeMe

    Genetic Association Database (GAD): GPSM3
    Human Genome Epidemiology (HuGE) Navigator: GPSM3 (6 documents)

    Export disorders for GPSM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPSM3 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with GPSM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of AGS4: a protein containing three G-protein regulatory motifs that regulate the activation state of Gialpha. (PubMed id 15096500)1, 2, 3 Cao X.... Lanier S.M. (J. Biol. Chem. 2004)
    2. Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif. (PubMed id 14656218)1, 2, 9 Kimple R.J....Siderovski D.P. (Biochem. J. 2004)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    5. Confirmation of the novel association at the BTNL2 locus with ulcerative colitis. (PubMed id 19659809)1, 4 Pathan S....Jewell D.P. (Tissue Antigens 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    8. Human major histocompatibility complex contains a new cluster of genes between the HLA-D and complement C4 loci. (PubMed id 2259622)1, 3 Kendall E.... Campbell R.D. (Nucleic Acids Res. 1990)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 63940 HGNC: 13945 AceView: NOTCH4 Ensembl:ENSG00000213654 euGenes: HUgn63940
    ECgene: GPSM3 H-InvDB: GPSM3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GPSM3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GPSM3 gene:
    Search GeneIP for patents involving GPSM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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