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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPSM3 Gene

protein-coding   GIFtS: 48
GCID: GC06M032229

G-Protein Signaling Modulator 3

(Previous names: chromosome 6 open reading frame 9, G-protein signalling...)
(Previous symbol: C6orf9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
G-Protein Signaling Modulator 31 2     Chromosome 6 Open Reading Frame 91
C6orf91 2 3     G18.1a2
Activator Of G-Protein Signaling 41 2 3     G18.22
G-Protein Signalling Modulator 3 (AGS3-Like, C. Elegans)1 2     NG12
AGS42 3     G-Protein Signaling Modulator 3 (AGS3-Like, C. Elegans)2
G182 3     G-Protein-Signaling Modulator 32
G18.1b2 3     Protein G183

External Ids:    HGNC: 139451   Entrez Gene: 639402   Ensembl: ENSG000002136547   UniProtKB: Q9Y4H43   

Export aliases for GPSM3 gene to outside databases

Previous GC identifers: GC06M032266 GC06M031912


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for GPSM3 Gene: 
GPSM3 (G-protein signaling modulator 3) is a protein-coding gene. Diseases associated with GPSM3 include prostate leiomyosarcoma, and leiomyosarcoma. GO annotations related to this gene include GTPase regulator activity and molecular_function.

UniProtKB/Swiss-Prot: GPSM3_HUMAN, Q9Y4H4
Function: Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NT_113891.2  NT_167244.1  NT_167246.1  NT_167247.1  NT_167248.1  NT_167249.1  
NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPSM3 gene promoter:
         HEN1   CREB   Pax-5   deltaCREB   STAT3   ITF-2   Tal-1beta   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for GPSM3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPSM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

GPSM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPSM3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M032229:  view genomic region     (about GC identifiers)

Start:
32,158,543 bp from pter      End:
32,163,300 bp from pter
Size:
4,758 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_167248 3,419,561-3,424,318      Chr6-,NT_167246 3,501,364-3,506,121      Chr6-,NT_167249 3,506,269-3,511,026     
Chr6-,NT_167244 3,473,281-3,478,038      Chr6-,NT_167247 3,538,367-3,543,124      Chr6-,NT_113891.2 3,629,221-3,633,978     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GPSM3_HUMAN, Q9Y4H4 (See protein sequence)
Recommended Name: G-protein-signaling modulator 3  
Size: 160 amino acids; 17866 Da
Subcellular location: Cytoplasm
Secondary accessions: A2BFJ3

Explore the universe of human proteins at neXtProt for GPSM3: NX_Q9Y4H4

Explore proteomics data for GPSM3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y4H4

  • GPSM3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GPSM3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_071390.1  NP_001263430.1  

    ENSEMBL proteins: 
     ENSP00000436358   ENSP00000432714   ENSP00000364180   ENSP00000364183  

    Human Recombinant Protein Products for GPSM3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for GPSM3
    OriGene Protein Over-expression Lysate for GPSM3
    OriGene MassSpec for GPSM3 
    OriGene Custom Protein Services for GPSM3
    GenScript Custom Purified and Recombinant Proteins Services for GPSM3
    Novus Biologicals GPSM3 Protein
    Novus Biologicals GPSM3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GPSM3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005737cytoplasm IEA--

    GPSM3 for ontologies           About GeneDecksing



    GPSM3 Antibody Products: 
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    Novus Biologicals GPSM3 Antibody
    Abcam antibodies for GPSM3
    Cloud-Clone Corp. Antibodies for GPSM3 
    ThermoFisher Antibodies for GPSM3
    LSBio Antibodies in human, mouse, rat for GPSM3 

    Assay Products for GPSM3: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GPSM3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GPSM3 
    Cloud-Clone Corp. CLIAs for GPSM3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003109 GoLoco_motif

    Graphical View of Domain Structure for InterPro Entry Q9Y4H4

    ProtoNet protein and cluster: Q9Y4H4

    UniProtKB/Swiss-Prot: GPSM3_HUMAN, Q9Y4H4
    Domain: The GoLoco 1 and/or GoLoco 3 domains exhibit GDI activity towards GDP-bound G(i) alpha protein, but not
    the GoLoco 2 domain
    Similarity: Contains 3 GoLoco domains


    GPSM3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPSM3_HUMAN, Q9Y4H4
    Function: Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005092GDP-dissociation inhibitor activity IEA--
    GO:0030695GTPase regulator activity ----
         
    GPSM3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GPSM3:
     Decreased cell number, increas 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gpsm3):
     cellular  hematopoietic system  immune system  skeleton 

    GPSM3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GPSM3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GPSM3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GPSM3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GPSM3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GPSM3
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate GPSM3:
    hsa-miR-1233 hsa-miR-525-5p hsa-miR-593 hsa-miR-1324 hsa-miR-520a-5p hsa-miR-1224-5p hsa-miR-3616-3p
    SwitchGear 3'UTR luciferase reporter plasmidGPSM3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GPSM3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPSM3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GPSM3
    Sirion Biotech Customized adenovirus for overexpression of GPSM3

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GPSM3 (see all 8)
    OriGene ORF clones in mouse, rat for GPSM3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GPSM3 (NM_022107)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPSM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPSM3
    Sirion Biotech Customized lentivirus for stable overexpression of GPSM3 
                         Customized lentivirus expression plasmids for stable overexpression of GPSM3 

    Cell Line
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    Search LifeMap BioReagents cell lines for GPSM3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPSM3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPSM3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for GPSM3 (Q9Y4H42, 3 ENSP000003641804) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR3P226072, 3, ENSP000002607954MINT-62616 MINT-62790 MINT-62714 I2D: score=4 STRING: ENSP00000260795
    GNAI1P630963, ENSP000003430274I2D: score=2 STRING: ENSP00000343027
    SVILO954253, ENSP000003481284I2D: score=1 STRING: ENSP00000348128
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway IEA--

    GPSM3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GPSM3

    Search CenterWatch for drugs/clinical trials and news about GPSM3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GPSM3 gene (2 alternative transcripts): 
    NM_022107.1  NM_001276501.1  

    Unigene Cluster for GPSM3:

    G-protein signaling modulator 3
    Hs.520046  [show with all ESTs]
    Unigene Representative Sequence: NM_001276501
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487761 ENST00000472768 ENST00000375040(uc003oay.4) ENST00000375043(uc003oaz.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GPSM3
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate GPSM3:
    hsa-miR-1233 hsa-miR-525-5p hsa-miR-593 hsa-miR-1324 hsa-miR-520a-5p hsa-miR-1224-5p hsa-miR-3616-3p
    SwitchGear 3'UTR luciferase reporter plasmidGPSM3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GPSM3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPSM3
    Clone
    Products:
         
    OriGene clones in human, mouse for GPSM3 (see all 8)
    OriGene ORF clones in mouse, rat for GPSM3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GPSM3 (NM_022107)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPSM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPSM3
    Sirion Biotech Customized lentivirus for stable overexpression of GPSM3 
                         Customized lentivirus expression plasmids for stable overexpression of GPSM3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GPSM3
    OriGene qSTAR qPCR primer pairs in human, mouse for GPSM3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GPSM3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPSM3
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPSM3

    Additional mRNA sequence: 

    AF155657.1 AJ243937.1 AJ243938.1 AK313922.1 BC018724.1 

    9 DOTS entries:

    DT.40106718  DT.100768197  DT.97861850  DT.86846834  DT.308880  DT.121378203  DT.102839413  DT.86846833 
    DT.95083137 

    24/222 AceView cDNA sequences (see all 222):

    BM811035 AI244789 BQ053714 BQ933211 CK821917 AJ243938 AI355714 BU146559 
    BG490215 BC018724 AI300614 BQ023076 BC063815 BM352627 BQ711693 AI093309 
    BQ183096 AL705928 CR604341 BI769793 BG743359 AJ243937 AI673445 BE858452 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPSM3 expression in normal human tissues (normalized intensities)      GPSM3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGCTTGAG
    GPSM3 Expression
    About this image


    GPSM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 8 entries
             Double Negative 2 Thymocytes Thymus
             Peripheral blood Pan-T Cells   
             neutrophils   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 4 entries
             Cord Blood CD133- Cells   
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Negative 2 Thymocytes Thymus
             Thymus
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Lymph (Hematopoietic System)
             Lymphnode   

    See GPSM3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GPSM3

    SOURCE GeneReport for Unigene cluster: Hs.520046

    UniProtKB/Swiss-Prot: GPSM3_HUMAN, Q9Y4H4
    Tissue specificity: Expressed in heart, placenta, lung and liver

        SABiosciences Custom PCR Arrays for GPSM3
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPSM3
    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPSM3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPSM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GPSM3 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpsm31 , 5 G-protein signalling modulator 3 (AGS3-like, C. elegans)1, 5 86.58(n)1
    88.68(a)1
      17 (18.17 cM)5
    1065121  NM_134116.51  NP_598877.11 
     345898065 
    lizard
    (Anolis carolinensis)
    Reptilia GPSM36
    G-protein signaling modulator 3
    40(a)
    1 ↔ 1
    2(198788406-198804680)
    zebrafish
    (Danio rerio)
    Actinopterygii GPSM36
    G-protein signaling modulator 3
    14(a)
    1 ↔ 1
    16(51935066-51947619)


    ENSEMBL Gene Tree for GPSM3 (if available)
    TreeFam Gene Tree for GPSM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/42 SNPs in GPSM3 are shown (see all 42)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2002902431,2
    --32159999(+) GAGGGG/TGCCAG 4 H P mis10--------
    rs2002744201,2
    --32160011(+) CTTCCG/TCATCC 4 E A mis10--------
    rs22694201,2
    C,F,H--32160153(-) GAAAGG/TCTTGG 2 -- int15Minor allele frequency- T:0.05NS EA 536
    rs1883507951,2
    --32160355(+) ACCTTC/GGGTTC 2 -- int1 ut510--------
    rs1922476041,2
    --32160438(+) GGGTTC/TCTGGT 2 -- int1 ut510--------
    rs1160673941,2
    F--32160448(+) TCAGCC/GCCCCC 2 -- int1 ut511Minor allele frequency- G:0.01WA 118
    rs95016051,2
    C,F,H--32160524(+) CTCTCG/ACCCCA 2 -- int1 ut5110Minor allele frequency- A:0.02NS EA WA 1298
    rs1409792261,2
    C--32160658(+) CCCTCC/TACCCC 2 -- int1 ut510--------
    rs1831631941,2
    --32160735(+) AATCCC/TCCTCC 2 -- int1 us2k10--------
    rs1455459631,2
    C--32160762(+) TCCCT-/CCCTAA 2 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for GPSM3 (32158543 - 32163300 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for GPSM3:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv6643n71CNV Loss21882294
    nsv884712CNV Loss21882294
    dgv6645n71CNV Loss21882294
    nsv830629CNV Loss17160897
    dgv6644n71CNV Loss21882294
    nsv884715CNV Loss21882294
    nsv462877CNV Loss19166990
    dgv1929e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GPSM3
    DNA2.0 Custom Variant and Variant Library Synthesis for GPSM3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    7 diseases for GPSM3:    About MalaCards
    prostate leiomyosarcoma    leiomyosarcoma    ulcerative colitis    hypercalcemia
    systemic lupus erythematosus    lupus erythematosus    prostatitis


    GPSM3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GPSM3
    Human Genome Epidemiology (HuGE) Navigator: GPSM3 (6 documents)

    Export disorders for GPSM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GPSM3 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with GPSM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of AGS4: a protein containing three G-protein regulatory motifs that regulate the activation state of Gialpha. (PubMed id 15096500)1, 2, 3 Cao X.... Lanier S.M. (2004)
    2. Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif. (PubMed id 14656218)1, 2, 9 Kimple R.J....Siderovski D.P. (2004)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (2009)
    5. Confirmation of the novel association at the BTNL2 lo cus with ulcerative colitis. (PubMed id 19659809)1, 4 Pathan S....Jewell D.P. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    8. Human major histocompatibility complex contains a new cluster of genes between the HLA-D and complement C4 loci. (PubMed id 2259622)1, 3 Kendall E.... Campbell R.D. (1990)
    9. Genome-wide association study identifies eight new sus ceptibility loci for atopic dermatitis in the Japanese population. (PubMed id 23042114)1 Hirota T....Tamari M. (2012)
    10. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 63940 HGNC: 13945 AceView: NOTCH4 Ensembl:ENSG00000213654 euGenes: HUgn63940
    ECgene: GPSM3 H-InvDB: GPSM3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GPSM3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GPSM3 gene:
    Search GeneIP for patents involving GPSM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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