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Aliases for GPSM3 Gene

Aliases for GPSM3 Gene

  • G Protein Signaling Modulator 3 2 3
  • Activator Of G-Protein Signaling 4 2 3 4
  • G-Protein Signalling Modulator 3 (AGS3-Like, C. Elegans) 2 3
  • G-Protein Signaling Modulator 3 2 5
  • C6orf9 3 4
  • G18.1b 3 4
  • AGS4 3 4
  • G18 3 4
  • G-Protein Signaling Modulator 3 (AGS3-Like, C. Elegans) 3
  • Chromosome 6 Open Reading Frame 9 2
  • G-Protein-Signaling Modulator 3 3
  • Protein G18 4
  • G18.1a 3
  • G18.2 3
  • NG1 3

External Ids for GPSM3 Gene

Previous HGNC Symbols for GPSM3 Gene

  • C6orf9

Previous GeneCards Identifiers for GPSM3 Gene

  • GC06M032229
  • GC06M032266
  • GC06M031912
  • GC06M032165

Summaries for GPSM3 Gene

GeneCards Summary for GPSM3 Gene

GPSM3 (G Protein Signaling Modulator 3) is a Protein Coding gene. Diseases associated with GPSM3 include Prostate Leiomyosarcoma and Griscelli Syndrome, Type 1. GO annotations related to this gene include GTPase regulator activity and GDP-dissociation inhibitor activity.

UniProtKB/Swiss-Prot for GPSM3 Gene

  • Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPSM3 Gene

Genomics for GPSM3 Gene

Regulatory Elements for GPSM3 Gene

Enhancers for GPSM3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G031733 1.9 FANTOM5 ENCODE dbSUPER 6.7 +458.1 458069 8.5 MLX CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF263 SP3 LY6G5C LSM2 LY6G5B VARS ABHD16A MICA EHMT2 PRRC2A C4A CLIC1
GH06G031792 2 FANTOM5 Ensembl ENCODE dbSUPER 5.4 +399.8 399829 6.7 CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D SSRP1 SKIV2L ATF6B LSM2 LY6G5B DDX39B BAG6 C4A VARS HLA-DRB5 RPL3P2
GH06G032435 1.9 FANTOM5 Ensembl ENCODE dbSUPER 1.4 -243.9 -243915 7.5 HDGF PKNOX1 ATF1 WRNIP1 SIN3A YY1 CBX5 ZNF143 ZNF207 FOS HLA-DRB1 HLA-DQB1 HLA-DRB5 HLA-DQA2 HLA-DRB6 C4A HLA-DQA1 HLA-DQB1-AS1 HLA-DRA PSMB8
GH06G032602 1.9 FANTOM5 Ensembl ENCODE dbSUPER 1.3 -411.7 -411650 10.3 HDGF PKNOX1 ATF1 ZNF143 FOS ZNF263 NFYC JUNB ZNF623 TBX21 HLA-DRB1 HLA-DRB5 HLA-DQA1 HLA-DQA2 HLA-DRB6 C4A HLA-DQB2 HLA-DOB HLA-DQB1 HLA-DMA
GH06G032633 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.3 -441.5 -441482 7.2 HDGF WRNIP1 FEZF1 GLI4 ZNF2 ZNF121 GLIS2 ZNF416 ZNF143 ZNF662 HLA-DQA1 HLA-DQB1 HLA-DQA2 HLA-DRB1 HLA-DQB2 HLA-DRB5 HLA-DRB6 PPT2 CYP21A1P HLA-DQB1-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPSM3 on UCSC Golden Path with GeneCards custom track

Promoters for GPSM3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000320274 -477 1601 CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21

Genomic Location for GPSM3 Gene

Chromosome:
6
Start:
32,190,766 bp from pter
End:
32,195,523 bp from pter
Size:
4,758 bases
Orientation:
Minus strand

Genomic View for GPSM3 Gene

Genes around GPSM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPSM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPSM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for GPSM3 Gene

  • Protein details for GPSM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4H4-GPSM3_HUMAN
    Recommended name:
    G-protein-signaling modulator 3
    Protein Accession:
    Q9Y4H4
    Secondary Accessions:
    • A2BFJ3

    Protein attributes for GPSM3 Gene

    Size:
    160 amino acids
    Molecular mass:
    17866 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPSM3 Gene

Post-translational modifications for GPSM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPSM3 Gene

No data available for DME Specific Peptides for GPSM3 Gene

Domains & Families for GPSM3 Gene

Protein Domains for GPSM3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9Y4H4

UniProtKB/Swiss-Prot:

GPSM3_HUMAN :
  • The GoLoco 1 and/or GoLoco 3 domains exhibit GDI activity towards GDP-bound G(i) alpha protein, but not the GoLoco 2 domain.
Domain:
  • The GoLoco 1 and/or GoLoco 3 domains exhibit GDI activity towards GDP-bound G(i) alpha protein, but not the GoLoco 2 domain.
genes like me logo Genes that share domains with GPSM3: view

No data available for Gene Families for GPSM3 Gene

Function for GPSM3 Gene

Molecular function for GPSM3 Gene

UniProtKB/Swiss-Prot Function:
Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins.

Gene Ontology (GO) - Molecular Function for GPSM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
GO:0030695 GTPase regulator activity IEA --
genes like me logo Genes that share ontologies with GPSM3: view
genes like me logo Genes that share phenotypes with GPSM3: view

Animal Models for GPSM3 Gene

MGI Knock Outs for GPSM3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPSM3 Gene

Localization for GPSM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPSM3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPSM3 gene
Compartment Confidence
plasma membrane 3
nucleus 3
extracellular 2
cytosol 2

Gene Ontology (GO) - Cellular Components for GPSM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with GPSM3: view

Pathways & Interactions for GPSM3 Gene

SuperPathways for GPSM3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPSM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002690 positive regulation of leukocyte chemotaxis IEA --
GO:0006955 immune response NAS --
GO:0008150 biological_process ND --
GO:0050729 positive regulation of inflammatory response IEA --
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with GPSM3: view

No data available for Pathways by source and SIGNOR curated interactions for GPSM3 Gene

Drugs & Compounds for GPSM3 Gene

No Compound Related Data Available

Transcripts for GPSM3 Gene

Unigene Clusters for GPSM3 Gene

G-protein signaling modulator 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPSM3 Gene

No ASD Table

Relevant External Links for GPSM3 Gene

GeneLoc Exon Structure for
GPSM3
ECgene alternative splicing isoforms for
GPSM3

Expression for GPSM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPSM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPSM3 Gene

This gene is overexpressed in Whole Blood (x35.1).

Protein differential expression in normal tissues from HIPED for GPSM3 Gene

This gene is overexpressed in NK cells (18.1), Cervix (14.5), Peripheral blood mononuclear cells (7.5), and CD4 Tcells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPSM3 Gene



Protein tissue co-expression partners for GPSM3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPSM3 Gene:

GPSM3

SOURCE GeneReport for Unigene cluster for GPSM3 Gene:

Hs.520046

mRNA Expression by UniProt/SwissProt for GPSM3 Gene:

Q9Y4H4-GPSM3_HUMAN
Tissue specificity: Expressed in heart, placenta, lung and liver.

Evidence on tissue expression from TISSUES for GPSM3 Gene

  • Blood(4.5)
  • Lung(4.2)
  • Liver(4.1)
  • Adrenal gland(4)
genes like me logo Genes that share expression patterns with GPSM3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPSM3 Gene

Orthologs for GPSM3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPSM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPSM3 34 35
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia GPSM3 34 35
  • 91.04 (n)
cow
(Bos Taurus)
Mammalia GPSM3 34
  • 90.83 (n)
rat
(Rattus norvegicus)
Mammalia Gpsm3 34
  • 87.13 (n)
mouse
(Mus musculus)
Mammalia Gpsm3 34 16 35
  • 86.58 (n)
oppossum
(Monodelphis domestica)
Mammalia GPSM3 35
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPSM3 35
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii GPSM3 35
  • 14 (a)
OneToOne
Species where no ortholog for GPSM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPSM3 Gene

ENSEMBL:
Gene Tree for GPSM3 (if available)
TreeFam:
Gene Tree for GPSM3 (if available)

Paralogs for GPSM3 Gene

No data available for Paralogs for GPSM3 Gene

Variants for GPSM3 Gene

Sequence variations from dbSNP and Humsavar for GPSM3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs148746475 Uncertain significance 32,197,424(+) GAATC(A/G)GGCAG nc-transcript-variant, upstream-variant-2KB, reference, stop-gained
rs1000931193 -- 32,194,571(+) CAGTT(A/C)CTAAG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001796081 -- 32,190,465(+) TGTCA(C/G)CTGGG intron-variant, upstream-variant-2KB
rs1001845749 -- 32,196,452(+) ACCCC(A/C)GTTGG intron-variant, upstream-variant-2KB
rs1002210751 -- 32,190,532(+) CCGGC(A/G)GCTCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPSM3 Gene

Variant ID Type Subtype PubMed ID
dgv10404n54 CNV loss 21841781
dgv10463n54 CNV loss 21841781
dgv10472n54 CNV loss 21841781
dgv10486n54 CNV loss 21841781
esv2759415 CNV gain+loss 17122850
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv462877 CNV loss 19166990
nsv602104 CNV loss 21841781
nsv602105 CNV loss 21841781
nsv602109 CNV loss 21841781
nsv830629 CNV loss 17160897

Variation tolerance for GPSM3 Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPSM3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPSM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPSM3 Gene

Disorders for GPSM3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPSM3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
prostate leiomyosarcoma
  • leiomyosarcoma of the prostate
griscelli syndrome, type 1
  • griscelli syndrome type 1
- elite association - COSMIC cancer census association via MalaCards
Search GPSM3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPSM3

Genetic Association Database (GAD)
GPSM3
Human Genome Epidemiology (HuGE) Navigator
GPSM3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPSM3
genes like me logo Genes that share disorders with GPSM3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPSM3 Gene

Publications for GPSM3 Gene

  1. Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif. (PMID: 14656218) Kimple R.J. … Siderovski D.P. (Biochem. J. 2004) 3 4 22 64
  2. Identification and characterization of AGS4: a protein containing three G-protein regulatory motifs that regulate the activation state of Gialpha. (PMID: 15096500) Cao X. … Lanier S.M. (J. Biol. Chem. 2004) 2 3 4 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
  5. Confirmation of the novel association at the BTNL2 locus with ulcerative colitis. (PMID: 19659809) Pathan S. … Jewell D.P. (Tissue Antigens 2009) 3 46 64

Products for GPSM3 Gene

Sources for GPSM3 Gene

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