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Aliases for GPSM3 Gene

Aliases for GPSM3 Gene

  • G-Protein Signaling Modulator 3 2 3 5
  • Activator Of G-Protein Signaling 4 2 3 4
  • G-Protein Signalling Modulator 3 (AGS3-Like, C. Elegans) 2 3
  • C6orf9 3 4
  • G18.1b 3 4
  • AGS4 3 4
  • G18 3 4
  • G-Protein Signaling Modulator 3 (AGS3-Like, C. Elegans) 3
  • Chromosome 6 Open Reading Frame 9 2
  • Protein G18 4
  • G18.1a 3
  • G18.2 3
  • NG1 3

External Ids for GPSM3 Gene

Previous HGNC Symbols for GPSM3 Gene

  • C6orf9

Previous GeneCards Identifiers for GPSM3 Gene

  • GC06M032229
  • GC06M032266
  • GC06M031912
  • GC06M032165

Summaries for GPSM3 Gene

GeneCards Summary for GPSM3 Gene

GPSM3 (G-Protein Signaling Modulator 3) is a Protein Coding gene. Diseases associated with GPSM3 include Aicardi-Goutieres Syndrome 4 and Prostate Leiomyosarcoma. GO annotations related to this gene include GTPase regulator activity and GDP-dissociation inhibitor activity.

UniProtKB/Swiss-Prot for GPSM3 Gene

  • Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPSM3 Gene

Genomics for GPSM3 Gene

Regulatory Elements for GPSM3 Gene

Enhancers for GPSM3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPSM3 on UCSC Golden Path with GeneCards custom track

Promoters for GPSM3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPSM3 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPSM3 Gene

32,190,766 bp from pter
32,195,523 bp from pter
4,758 bases
Minus strand

Genomic View for GPSM3 Gene

Genes around GPSM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPSM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPSM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for GPSM3 Gene

  • Protein details for GPSM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein-signaling modulator 3
    Protein Accession:
    Secondary Accessions:
    • A2BFJ3

    Protein attributes for GPSM3 Gene

    160 amino acids
    Molecular mass:
    17866 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPSM3 Gene

Proteomics data for GPSM3 Gene at MOPED

Post-translational modifications for GPSM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPSM3 Gene

No data available for DME Specific Peptides for GPSM3 Gene

Domains & Families for GPSM3 Gene

Protein Domains for GPSM3 Gene


Graphical View of Domain Structure for InterPro Entry



  • The GoLoco 1 and/or GoLoco 3 domains exhibit GDI activity towards GDP-bound G(i) alpha protein, but not the GoLoco 2 domain.
  • The GoLoco 1 and/or GoLoco 3 domains exhibit GDI activity towards GDP-bound G(i) alpha protein, but not the GoLoco 2 domain.
  • Contains 3 GoLoco domains.
genes like me logo Genes that share domains with GPSM3: view

No data available for Gene Families for GPSM3 Gene

Function for GPSM3 Gene

Molecular function for GPSM3 Gene

UniProtKB/Swiss-Prot Function:
Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins.
genes like me logo Genes that share phenotypes with GPSM3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPSM3 Gene

Localization for GPSM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPSM3 Gene


Subcellular locations from

Jensen Localization Image for GPSM3 Gene COMPARTMENTS Subcellular localization image for GPSM3 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for GPSM3 Gene

Pathways & Interactions for GPSM3 Gene

SuperPathways for GPSM3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPSM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002690 positive regulation of leukocyte chemotaxis IEA --
GO:0008150 biological_process ND --
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with GPSM3: view

No data available for Pathways by source and SIGNOR curated interactions for GPSM3 Gene

Drugs & Compounds for GPSM3 Gene

No Compound Related Data Available

Transcripts for GPSM3 Gene

Unigene Clusters for GPSM3 Gene

G-protein signaling modulator 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPSM3 Gene

No ASD Table

Relevant External Links for GPSM3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPSM3 Gene

mRNA expression in normal human tissues for GPSM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPSM3 Gene

This gene is overexpressed in Whole Blood (x35.1).

Protein differential expression in normal tissues from HIPED for GPSM3 Gene

This gene is overexpressed in NK cells (18.1), Cervix (14.5), Peripheral blood mononuclear cells (7.5), and CD4 Tcells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPSM3 Gene

SOURCE GeneReport for Unigene cluster for GPSM3 Gene Hs.520046

mRNA Expression by UniProt/SwissProt for GPSM3 Gene

Tissue specificity: Expressed in heart, placenta, lung and liver.
genes like me logo Genes that share expression patterns with GPSM3: view

Protein tissue co-expression partners for GPSM3 Gene

- Elite partner

Primer Products

Orthologs for GPSM3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPSM3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPSM3 35
  • 90.83 (n)
  • 91.25 (a)
(Canis familiaris)
Mammalia GPSM3 35
  • 91.04 (n)
  • 92.5 (a)
GPSM3 36
  • 93 (a)
(Mus musculus)
Mammalia Gpsm3 35
  • 86.58 (n)
  • 88.68 (a)
Gpsm3 16
Gpsm3 36
  • 89 (a)
(Pan troglodytes)
Mammalia GPSM3 35
  • 99.37 (n)
  • 100 (a)
GPSM3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gpsm3 35
  • 87.13 (n)
  • 87.97 (a)
(Monodelphis domestica)
Mammalia GPSM3 36
  • 77 (a)
(Anolis carolinensis)
Reptilia GPSM3 36
  • 46 (a)
(Danio rerio)
Actinopterygii GPSM3 36
  • 14 (a)
Species with no ortholog for GPSM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPSM3 Gene

Gene Tree for GPSM3 (if available)
Gene Tree for GPSM3 (if available)

Paralogs for GPSM3 Gene

No data available for Paralogs for GPSM3 Gene

Variants for GPSM3 Gene

Sequence variations from dbSNP and Humsavar for GPSM3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs9501605 -- 32,192,747(+) CTCTC(A/G)CCCCA intron-variant, utr-variant-5-prime
rs204989 -- 32,194,075(-) tgctt(C/T)attac intron-variant, upstream-variant-2KB
rs204990 -- 32,193,653(-) TCATT(G/T)TTCCA intron-variant, upstream-variant-2KB
rs204991 -- 32,193,589(-) AAACT(A/G)TAAGT intron-variant, upstream-variant-2KB
rs2269420 -- 32,192,376(-) GAAAG(C/G/T)CTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPSM3 Gene

Variant ID Type Subtype PubMed ID
dgv1929e1 CNV Complex 17122850
nsv830629 CNV Loss 17160897
nsv462877 CNV Loss 19166990
dgv6643n71 CNV Loss 21882294
dgv6644n71 CNV Loss 21882294
dgv6645n71 CNV Loss 21882294
nsv884712 CNV Loss 21882294
nsv884715 CNV Loss 21882294

Variation tolerance for GPSM3 Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.43% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPSM3 Gene

Disorders for GPSM3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPSM3 Gene - From: OMIM and DISEASES

Disorder Aliases PubMed IDs
aicardi-goutieres syndrome 4
  • cree encephalitis
prostate leiomyosarcoma
  • leiomyosarcoma of the prostate
- elite association - COSMIC cancer census association via MalaCards
Search GPSM3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPSM3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GPSM3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPSM3 Gene

Publications for GPSM3 Gene

  1. Identification and characterization of AGS4: a protein containing three G-protein regulatory motifs that regulate the activation state of Gialpha. (PMID: 15096500) Cao X. … Lanier S.M. (J. Biol. Chem. 2004) 2 3 4 67
  2. Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif. (PMID: 14656218) Kimple R.J. … Siderovski D.P. (Biochem. J. 2004) 3 23
  3. Human major histocompatibility complex contains a new cluster of genes between the HLA-D and complement C4 loci. (PMID: 2259622) Kendall E. … Campbell R.D. (Nucleic Acids Res. 1990) 2 3
  4. G Protein signaling modulator-3 inhibits the inflammasome activity of NLRP3. (PMID: 25271165) GiguA"re P.M. … Duncan J.A. (J. Biol. Chem. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for GPSM3 Gene

Sources for GPSM3 Gene