Aliases for GPSM2 Gene
External Ids for GPSM2 Gene
Previous HGNC Symbols for GPSM2 Gene
Previous GeneCards Identifiers for GPSM2 Gene
The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82).[provided by RefSeq, Jan 2011]
GeneCards Summary for GPSM2 Gene
GPSM2 (G-Protein Signaling Modulator 2) is a Protein Coding gene. Diseases associated with GPSM2 include chudley-mccullough syndrome and prostate carcinoma in situ. GO annotations related to this gene include identical protein binding and GDP-dissociation inhibitor activity. An important paralog of this gene is GPSM1.
UniProtKB/Swiss-Prot for GPSM2 Gene
Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions.