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Aliases for GPSM1 Gene

Aliases for GPSM1 Gene

  • G-Protein Signaling Modulator 1 2 3
  • G-Protein Signalling Modulator 1 (AGS3-Like, C. Elegans) 2 3
  • Activator Of G-Protein Signaling 3 3 4
  • AGS3 3 4
  • G-Protein-Signaling Modulator 1 3
  • AGS3 Homolog (C. Elegans) 2

External Ids for GPSM1 Gene

Previous GeneCards Identifiers for GPSM1 Gene

  • GC09P134606
  • GC09P136497
  • GC09P138348
  • GC09P139221
  • GC09P108682

Summaries for GPSM1 Gene

Entrez Gene Summary for GPSM1 Gene

  • G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for GPSM1 Gene

GPSM1 (G-Protein Signaling Modulator 1) is a Protein Coding gene. Among its related pathways are Amphetamine addiction. GO annotations related to this gene include GDP-dissociation inhibitor activity. An important paralog of this gene is GPSM2.

UniProtKB/Swiss-Prot for GPSM1 Gene

  • Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.

Gene Wiki entry for GPSM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPSM1 Gene

Genomics for GPSM1 Gene

Regulatory Elements for GPSM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GPSM1 Gene

Start:
136,327,476 bp from pter
End:
136,359,605 bp from pter
Size:
32,130 bases
Orientation:
Plus strand

Genomic View for GPSM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPSM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPSM1 Gene

Proteins for GPSM1 Gene

  • Protein details for GPSM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YR5-GPSM1_HUMAN
    Recommended name:
    G-protein-signaling modulator 1
    Protein Accession:
    Q86YR5
    Secondary Accessions:
    • A9Z1X4
    • B1B0W3
    • Q86SR5
    • Q969T1
    • Q9UFS8

    Protein attributes for GPSM1 Gene

    Size:
    675 amino acids
    Molecular mass:
    74510 Da
    Quaternary structure:
    • Interacts with GNAI1, GNAI2 and GNAI3 preferentially in their GDP-bound state. May also interact with GNAO1. Interacts with STK11/LKB1 and MACF1 (By similarity). Interacts with INSC/inscuteable and FRMPD1.
    SequenceCaution:
    • Sequence=AAH09979.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH17353.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB55951.1; Type=Frameshift; Positions=657; Evidence={ECO:0000305}; Sequence=CAI19339.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for GPSM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPSM1 Gene

Proteomics data for GPSM1 Gene at MOPED

Post-translational modifications for GPSM1 Gene

No data available for DME Specific Peptides for GPSM1 Gene

Domains for GPSM1 Gene

Gene Families for GPSM1 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for GPSM1 Gene

Suggested Antigen Peptide Sequences for GPSM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YR5

UniProtKB/Swiss-Prot:

GPSM1_HUMAN :
  • Q86YR5
Domain:
  • The GoLoco domains mediate interaction with G(i/o) alpha (By similarity). The GoLoco domains are essential for the GDI activity toward G(i/o) alpha.
  • Contains 4 GoLoco domains.
Family:
  • Belongs to the GPSM family.
Similarity:
  • Contains 9 TPR repeats.
genes like me logo Genes that share domains with GPSM1: view

Function for GPSM1 Gene

Molecular function for GPSM1 Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.

Gene Ontology (GO) - Molecular Function for GPSM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005092 GDP-dissociation inhibitor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0030695 GTPase regulator activity --
genes like me logo Genes that share ontologies with GPSM1: view
genes like me logo Genes that share phenotypes with GPSM1: view

Animal Models for GPSM1 Gene

MGI Knock Outs for GPSM1:

Animal Model Products

CRISPR Products

miRNA for GPSM1 Gene

miRTarBase miRNAs that target GPSM1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GPSM1 Gene

Localization for GPSM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPSM1 Gene

Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPSM1 Gene COMPARTMENTS Subcellular localization image for GPSM1 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 5
nucleus 4

Gene Ontology (GO) - Cellular Components for GPSM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005654 nucleoplasm IDA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with GPSM1: view

Pathways for GPSM1 Gene

SuperPathways for GPSM1 Gene

Superpath Contained pathways
1 Amphetamine addiction
genes like me logo Genes that share pathways with GPSM1: view

Pathways by source for GPSM1 Gene

1 KEGG pathway for GPSM1 Gene

Gene Ontology (GO) - Biological Process for GPSM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA --
GO:0030154 cell differentiation IEA --
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with GPSM1: view

Compounds for GPSM1 Gene

(3) HMDB Compounds for GPSM1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1

(4) Novoseek inferred chemical compound relationships for GPSM1 Gene

Compound -log(P) Hits PubMed IDs
guanosine 5-o-(3-thiotriphosphate) 56.9 1
gdp 41.3 3
gtp 39.7 2
guanine 34.4 1
genes like me logo Genes that share compounds with GPSM1: view

Transcripts for GPSM1 Gene

Unigene Clusters for GPSM1 Gene

G-protein signaling modulator 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPSM1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPSM1 Gene

No ASD Table

Relevant External Links for GPSM1 Gene

GeneLoc Exon Structure for
GPSM1
ECgene alternative splicing isoforms for
GPSM1

Expression for GPSM1 Gene

mRNA expression in normal human tissues for GPSM1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GPSM1 Gene

SOURCE GeneReport for Unigene cluster for GPSM1 Gene Hs.239370

mRNA Expression by UniProt/SwissProt for GPSM1 Gene

Q86YR5-GPSM1_HUMAN
Tissue specificity: Expressed in intestinal cells.
genes like me logo Genes that share expressions with GPSM1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for GPSM1 Gene

Orthologs for GPSM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPSM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPSM1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPSM1 35
  • 89.38 (n)
  • 92.92 (a)
GPSM1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPSM1 35
  • 88.62 (n)
  • 91.85 (a)
GPSM1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpsm1 35
  • 85.59 (n)
  • 92.77 (a)
Gpsm1 16
Gpsm1 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 55 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gpsm1 35
  • 85.84 (n)
  • 93.47 (a)
chicken
(Gallus gallus)
Aves GPSM1 35
  • 73.23 (n)
  • 78.27 (a)
GPSM1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPSM1 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8244 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gpsm1 35
  • 72.67 (n)
  • 74.72 (a)
zebrafish
(Danio rerio)
Actinopterygii gpsm1a 36
  • 50 (a)
OneToMany
gpsm1b 35
  • 70.1 (n)
  • 71.69 (a)
gpsm1b 36
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta raps 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ags-3 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5850 36
  • 57 (a)
ManyToMany
CSA.9104 36
  • 32 (a)
ManyToMany
Species with no ortholog for GPSM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPSM1 Gene

ENSEMBL:
Gene Tree for GPSM1 (if available)
TreeFam:
Gene Tree for GPSM1 (if available)

Paralogs for GPSM1 Gene

Paralogs for GPSM1 Gene

Selected SIMAP similar genes for GPSM1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPSM1: view

Variants for GPSM1 Gene

Sequence variations from dbSNP and Humsavar for GPSM1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1128905 -- 136,359,387(+) CCTGG(C/T)GAGGT utr-variant-3-prime
rs1128908 -- 136,359,550(+) CCCAA(A/G)AGGTA utr-variant-3-prime
rs3125013 -- 136,357,801(+) CCTGC(A/G/T)GGTTG intron-variant
rs3812547 -- 136,358,043(+) TGCCC(A/G)CCACC synonymous-codon, reference
rs3812548 -- 136,358,082(+) CCGGA(C/T)GAGGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for GPSM1 Gene

Variant ID Type Subtype PubMed ID
nsv825173 CNV Gain 20364138
nsv894294 CNV Loss 21882294
dgv8383n71 CNV Loss 21882294
dgv8384n71 CNV Loss 21882294
dgv8385n71 CNV Loss 21882294
nsv894319 CNV Gain 21882294
dgv8386n71 CNV Loss 21882294
dgv8387n71 CNV Loss 21882294
dgv8389n71 CNV Loss 21882294
dgv8390n71 CNV Loss 21882294
dgv8392n71 CNV Loss 21882294
dgv8393n71 CNV Loss 21882294
nsv894357 CNV Loss 21882294
nsv894359 CNV Loss 21882294
nsv894360 CNV Loss 21882294
nsv6764 CNV Loss 18451855
nsv509333 CNV Insertion 20534489
esv2656654 CNV Deletion 23128226
esv2739355 CNV Deletion 23290073
esv2739356 CNV Deletion 23290073
esv2739357 CNV Deletion 23290073
esv1008862 CNV Deletion 20482838
esv2739358 CNV Deletion 23290073
nsv482928 CNV Loss 15286789
dgv2426e1 CNV Complex 17122850
nsv894361 CNV Loss 21882294

Relevant External Links for GPSM1 Gene

HapMap Linkage Disequilibrium report
GPSM1
Human Gene Mutation Database (HGMD)
GPSM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPSM1 Gene

Disorders for GPSM1 Gene

(1) Novoseek inferred disease relationships for GPSM1 Gene

Disease -log(P) Hits PubMed IDs
colon cancer 19.6 1

Relevant External Links for GPSM1

Human Genome Epidemiology (HuGE) Navigator
GPSM1
genes like me logo Genes that share disorders with GPSM1: view

No data available for UniProtKB/Swiss-Prot for GPSM1 Gene

Publications for GPSM1 Gene

  1. Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3. (PMID: 10969064) Peterson Y.K. … Lanier S.M. (J. Biol. Chem. 2000) 2 3 23
  2. Identification of a truncated form of the G-protein regulator AGS3 in heart that lacks the tetratricopeptide repeat domains. (PMID: 11278352) Pizzinat N. … Lanier S.M. (J. Biol. Chem. 2001) 2 3 23
  3. The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells. (PMID: 12642577) Pattingre S. … Codogno P. (J. Biol. Chem. 2003) 3 4 23
  4. Distribution of activator of G-protein signaling 3 within the aggresomal pathway: role of specific residues in the tetratricopeptide repeat domain and differential regulation by the AGS3 binding partners Gi(alpha) and mammalian inscuteable. (PMID: 20065032) Vural A. … Lanier S.M. (Mol. Cell. Biol. 2010) 3 23
  5. An inhibitory role of the G-protein regulator AGS3 in mTOR-dependent macroautophagy. (PMID: 20126274) Groves B. … Ma D. (PLoS ONE 2010) 3 23

Products for GPSM1 Gene

Sources for GPSM1 Gene

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