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Aliases for GPSM1 Gene

Aliases for GPSM1 Gene

  • G-Protein Signaling Modulator 1 2 3 5
  • G-Protein Signalling Modulator 1 (AGS3-Like, C. Elegans) 2 3
  • Activator Of G-Protein Signaling 3 3 4
  • AGS3 3 4
  • G-Protein-Signaling Modulator 1 3
  • AGS3 Homolog (C. Elegans) 2

External Ids for GPSM1 Gene

Previous GeneCards Identifiers for GPSM1 Gene

  • GC09P134606
  • GC09P136497
  • GC09P138348
  • GC09P139221
  • GC09P108682

Summaries for GPSM1 Gene

Entrez Gene Summary for GPSM1 Gene

  • G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for GPSM1 Gene

GPSM1 (G-Protein Signaling Modulator 1) is a Protein Coding gene. Diseases associated with GPSM1 include Drug Addiction. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include GTPase regulator activity and GDP-dissociation inhibitor activity. An important paralog of this gene is GPSM2.

UniProtKB/Swiss-Prot for GPSM1 Gene

  • Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.

Gene Wiki entry for GPSM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPSM1 Gene

Genomics for GPSM1 Gene

Regulatory Elements for GPSM1 Gene

Enhancers for GPSM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F136340 1.7 FANTOM5 Ensembl ENCODE 12.8 +15.0 15042 3.6 TBP HDAC1 PKNOX1 THRB GLIS2 EGR1 CREM KLF13 EGR2 ZNF263 DNLZ GPSM1 INPP5E
GH09F136266 1.2 Ensembl ENCODE 12.7 -59.5 -59527 2.3 HDGF PKNOX1 KLF17 ARID4B GLI4 RAD21 ZNF121 GTF3C2 ZNF143 KLF7 ANAPC2 GPSM1 SNHG7 LHX3 NDOR1 ENSG00000264527 LOC101928722 CCDC187
GH09F136408 0.9 ENCODE 11.9 +83.0 82977 3.6 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF548 SP3 INPP5E DNLZ SEC16A SNAPC4 SNHG7 GPSM1 CARD9 ANAPC2 GC09M136410 PIR36061
GH09F136344 1.2 Ensembl ENCODE 11.8 +18.5 18539 3.4 ELF3 HDAC1 ATF1 ARID4B DMAP1 THRB ZNF48 ZSCAN9 RAD21 ZNF143 DNLZ INPP5E GPSM1
GH09F136353 1.2 Ensembl ENCODE 10.9 +27.7 27723 3.4 TBP PKNOX1 KLF17 ARID4B ZNF48 RARA GLIS2 EGR2 SP5 GLIS1 DNLZ INPP5E SNAPC4 GPSM1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GPSM1 on UCSC Golden Path with GeneCards custom track

Promoters for GPSM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001475874 724 2001 KLF17 SIN3A ZNF2 ZEB1 GLIS2 ZNF391 CREM EGR2 ZNF263 SMAD5

Genomic Location for GPSM1 Gene

Chromosome:
9
Start:
136,327,476 bp from pter
End:
136,359,605 bp from pter
Size:
32,130 bases
Orientation:
Plus strand

Genomic View for GPSM1 Gene

Genes around GPSM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPSM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPSM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPSM1 Gene

Proteins for GPSM1 Gene

  • Protein details for GPSM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YR5-GPSM1_HUMAN
    Recommended name:
    G-protein-signaling modulator 1
    Protein Accession:
    Q86YR5
    Secondary Accessions:
    • A9Z1X4
    • B1B0W3
    • Q86SR5
    • Q969T1
    • Q9UFS8

    Protein attributes for GPSM1 Gene

    Size:
    675 amino acids
    Molecular mass:
    74510 Da
    Quaternary structure:
    • Interacts with GNAI1, GNAI2 and GNAI3 preferentially in their GDP-bound state. May also interact with GNAO1. Interacts with STK11/LKB1 and MACF1 (By similarity). Interacts with INSC/inscuteable and FRMPD1.
    SequenceCaution:
    • Sequence=AAH09979.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH17353.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB55951.1; Type=Frameshift; Positions=657; Evidence={ECO:0000305}; Sequence=CAI19339.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for GPSM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPSM1 Gene

Post-translational modifications for GPSM1 Gene

No data available for DME Specific Peptides for GPSM1 Gene

Domains & Families for GPSM1 Gene

Gene Families for GPSM1 Gene

Suggested Antigen Peptide Sequences for GPSM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YR5

UniProtKB/Swiss-Prot:

GPSM1_HUMAN :
  • The GoLoco domains mediate interaction with G(i/o) alpha (By similarity). The GoLoco domains are essential for the GDI activity toward G(i/o) alpha.
  • Belongs to the GPSM family.
  • Contains 9 TPR repeats.
Domain:
  • The GoLoco domains mediate interaction with G(i/o) alpha (By similarity). The GoLoco domains are essential for the GDI activity toward G(i/o) alpha.
  • Contains 4 GoLoco domains.
Family:
  • Belongs to the GPSM family.
Similarity:
  • Contains 9 TPR repeats.
genes like me logo Genes that share domains with GPSM1: view

Function for GPSM1 Gene

Molecular function for GPSM1 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.

Gene Ontology (GO) - Molecular Function for GPSM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005092 GDP-dissociation inhibitor activity IEA --
GO:0030695 GTPase regulator activity IEA --
genes like me logo Genes that share ontologies with GPSM1: view
genes like me logo Genes that share phenotypes with GPSM1: view

Animal Models for GPSM1 Gene

MGI Knock Outs for GPSM1:

Animal Model Products

miRNA for GPSM1 Gene

miRTarBase miRNAs that target GPSM1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPSM1 Gene

Localization for GPSM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPSM1 Gene

Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPSM1 Gene COMPARTMENTS Subcellular localization image for GPSM1 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 5
nucleus 4

Gene Ontology (GO) - Cellular Components for GPSM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with GPSM1: view

Pathways & Interactions for GPSM1 Gene

genes like me logo Genes that share pathways with GPSM1: view

Pathways by source for GPSM1 Gene

Gene Ontology (GO) - Biological Process for GPSM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA --
GO:0030154 cell differentiation IEA --
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with GPSM1: view

No data available for SIGNOR curated interactions for GPSM1 Gene

Drugs & Compounds for GPSM1 Gene

(4) Drugs for GPSM1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(3) Additional Compounds for GPSM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GPSM1: view

Transcripts for GPSM1 Gene

Unigene Clusters for GPSM1 Gene

G-protein signaling modulator 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPSM1 Gene

No ASD Table

Relevant External Links for GPSM1 Gene

GeneLoc Exon Structure for
GPSM1
ECgene alternative splicing isoforms for
GPSM1

Expression for GPSM1 Gene

mRNA expression in normal human tissues for GPSM1 Gene

Protein differential expression in normal tissues from HIPED for GPSM1 Gene

This gene is overexpressed in Fetal Brain (31.2), Heart (13.9), and Frontal cortex (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPSM1 Gene



Protein tissue co-expression partners for GPSM1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPSM1 Gene:

GPSM1

SOURCE GeneReport for Unigene cluster for GPSM1 Gene:

Hs.239370

mRNA Expression by UniProt/SwissProt for GPSM1 Gene:

Q86YR5-GPSM1_HUMAN
Tissue specificity: Expressed in intestinal cells.
genes like me logo Genes that share expression patterns with GPSM1: view

Primer Products

No data available for mRNA differential expression in normal tissues for GPSM1 Gene

Orthologs for GPSM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPSM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPSM1 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPSM1 34 35
  • 89.38 (n)
dog
(Canis familiaris)
Mammalia GPSM1 34 35
  • 88.62 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 88 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 86 (a)
OneToMany
-- 35
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gpsm1 34
  • 85.84 (n)
mouse
(Mus musculus)
Mammalia Gpsm1 34 16 35
  • 85.59 (n)
chicken
(Gallus gallus)
Aves GPSM1 34 35
  • 73.23 (n)
lizard
(Anolis carolinensis)
Reptilia GPSM1 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpsm1 34
  • 72.67 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8244 34
zebrafish
(Danio rerio)
Actinopterygii gpsm1b 34 35
  • 70.1 (n)
gpsm1a 35
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta raps 35
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ags-3 35
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5850 35
  • 57 (a)
ManyToMany
CSA.9104 35
  • 32 (a)
ManyToMany
Species where no ortholog for GPSM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPSM1 Gene

ENSEMBL:
Gene Tree for GPSM1 (if available)
TreeFam:
Gene Tree for GPSM1 (if available)

Paralogs for GPSM1 Gene

Paralogs for GPSM1 Gene

(2) SIMAP similar genes for GPSM1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPSM1: view

Variants for GPSM1 Gene

Sequence variations from dbSNP and Humsavar for GPSM1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10870125 -- 136,358,616(+) GGCCA(C/T)CAAGG utr-variant-3-prime
rs111274959 -- 136,333,662(+) ACGGC(A/G)GAGTT intron-variant, upstream-variant-2KB
rs111368544 -- 136,332,434(+) GAGGC(A/G)GGAGG intron-variant
rs111451417 -- 136,337,171(+) CTCCC(A/G)ACAGC intron-variant
rs11145776 -- 136,356,554(+) AGGTG(A/G)GCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPSM1 Gene

Variant ID Type Subtype PubMed ID
esv1008862 CNV deletion 20482838
esv2656654 CNV deletion 23128226
esv2739355 CNV deletion 23290073
esv2739356 CNV deletion 23290073
esv2739357 CNV deletion 23290073
esv2739358 CNV deletion 23290073
esv2759720 CNV loss 17122850
esv3545636 CNV deletion 23714750
nsv1046074 CNV gain 25217958
nsv1122251 CNV deletion 24896259
nsv473617 CNV novel sequence insertion 20440878
nsv475917 CNV novel sequence insertion 20440878
nsv479104 CNV novel sequence insertion 20440878
nsv480016 CNV novel sequence insertion 20440878
nsv481115 CNV novel sequence insertion 20440878
nsv509333 CNV insertion 20534489
nsv615962 CNV loss 21841781
nsv6764 CNV deletion 18451855
nsv825173 CNV gain 20364138
nsv951202 CNV deletion 24416366

Variation tolerance for GPSM1 Gene

Residual Variation Intolerance Score: 28.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.64; 78.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPSM1 Gene

Human Gene Mutation Database (HGMD)
GPSM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPSM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPSM1 Gene

Disorders for GPSM1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPSM1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
drug addiction
  • drug dependence
- elite association - COSMIC cancer census association via MalaCards
Search GPSM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPSM1

Human Genome Epidemiology (HuGE) Navigator
GPSM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPSM1
genes like me logo Genes that share disorders with GPSM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPSM1 Gene

Publications for GPSM1 Gene

  1. The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells. (PMID: 12642577) Pattingre S. … Codogno P. (J. Biol. Chem. 2003) 3 4 22 64
  2. Identification of a truncated form of the G-protein regulator AGS3 in heart that lacks the tetratricopeptide repeat domains. (PMID: 11278352) Pizzinat N. … Lanier S.M. (J. Biol. Chem. 2001) 2 3 22 64
  3. Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3. (PMID: 10969064) Peterson Y.K. … Lanier S.M. (J. Biol. Chem. 2000) 2 3 22 64
  4. Distribution of activator of G-protein signaling 3 within the aggresomal pathway: role of specific residues in the tetratricopeptide repeat domain and differential regulation by the AGS3 binding partners Gi(alpha) and mammalian inscuteable. (PMID: 20065032) Vural A. … Lanier S.M. (Mol. Cell. Biol. 2010) 3 22 64
  5. An inhibitory role of the G-protein regulator AGS3 in mTOR-dependent macroautophagy. (PMID: 20126274) Groves B. … Ma D. (PLoS ONE 2010) 3 22 64

Products for GPSM1 Gene

Sources for GPSM1 Gene

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