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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GPSM1 Gene

protein-coding GIFtS: 53
GCID: GC09P139221

G-protein signaling modulator 1

(Previous names: G-protein signalling modulator 1 (AGS3-like, C. elegans)...)

Explore 7 diseases affiliated with
GPSM1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
G-Protein Signaling Modulator 1¹ ²		DKFZP727I051¹
AGS3¹ ² ³		AGS3 Homolog²
G-Protein Signalling Modulator 1 (AGS3-Like, C. Elegans)¹ ²		G-Protein-Signaling Modulator 1²
Activator Of G-Protein Signaling 3² ³

External Ids:	HGNC: 17858¹	Entrez Gene: 26086²	Ensembl: ENSG00000160360⁷	OMIM: 609491⁵	UniProtKB: Q86YR5³

Export aliases for GPSM1 gene to outside databases

Previous GC identifers: GC09P134606 GC09P136497 GC09P138348 GC09P108682

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GPSM1:

G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits.

This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that

influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in

its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced

transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: GPSM1_HUMAN, Q86YR5

Function: Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of

heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric

G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of

cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug

addiction

Gene Wiki entry for GPSM1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_024000.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GPSM1 gene promoter:
SREBP-1c CUTL1 SREBP-1b Max SREBP-1a HSF2 NF-kappaB1 LyF-1 Zic3 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GPSM1 promoter sequence

Search SABiosciences Chromatin IP Primers for GPSM1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPSM1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34.3

GPSM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPSM1 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P139221: view genomic region (about GC identifiers)

Start:	139,221,932 bp from pter	End:	139,254,057 bp from pter
Size:	32,126 bases	Orientation:	plus strand

1 alternative location:

Chr9+,PATCHES 139,235,377-139,266,277

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GPSM1_HUMAN, Q86YR5 (See protein sequence)

Recommended Name: G-protein-signaling modulator 1

Size: 675 amino acids; 74510 Da

Subunit: Interacts with GNAI1, GNAI2 and GNAI3 preferentially in their GDP-bound state. May also interact with GNAO1.

Interacts with STK11/LKB1 and MACF1 (By similarity). Interacts with INSC/inscuteable and FRMPD1

Subcellular location: Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic

side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane

protein; Cytoplasmic side

Sequence caution: Sequence=AAH09979.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=AAH17353.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAB55951.1;

Type=Frameshift; Positions=657; Sequence=CAI19339.1; Type=Erroneous gene model prediction;

Secondary accessions: A9Z1X4 B1B0W3 Q86SR5 Q969T1 Q9UFS8

Alternative splicing: 4 isoforms: Q86YR5-1 Q86YR5-2 Q86YR5-3 Q86YR5-4 (Major isoform)

Explore the universe of human proteins at neXtProt for GPSM1: NX_Q86YR5

Post-translational modifications:

Phosphorylation regulates interaction with G(i/o) alpha (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86YR5

GPSM1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001139110.1 NP_001139111.1 NP_001186932.1 NP_056412.4

ENSEMBL proteins:

ENSP00000376674 ENSP00000346797 ENSP00000376673 ENSP00000291775 ENSP00000392828

ENSP00000390705

Human Recombinant Protein Products:

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	Novus Biologicals GPSM1 Proteins Novus Biologicals GPSM1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for GPSM1

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005794	Golgi apparatus	IDA	--

GPSM1 for ontologies About GeneDecksing

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	Uscn Antibodies for GPSM1
	Search ThermoFisher Antibodies for GPSM1

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	GenScript Custom Assay Services for GPSM1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for GPSM1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GPSM1 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR011990 TPR-like_helical

IPR003109 GoLoco_motif

IPR001440 TPR-1

IPR024804 G_prot_signal_mod_1

IPR013026 TPR-contain_dom

Graphical View of Domain Structure for InterPro Entry Q86YR5

ProtoNet protein and cluster: Q86YR5

UniProtKB/Swiss-Prot: GPSM1_HUMAN, Q86YR5

Domain: The GoLoco domains mediate interaction with G(i/o) alpha (By similarity). The GoLoco domains are essential for

the GDI activity toward G(i/o) alpha

Similarity: Belongs to the GPSM family

Similarity: Contains 4 GoLoco domains

Similarity: Contains 9 TPR repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GPSM1_HUMAN, Q86YR5

Function: Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of

heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric

G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of

cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug

addiction

miRNA Products:		OriGene 3'-UTR Clone (see all 3): GPSM1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GPSM1
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate GPSM1 (see all 14):
		hsa-miR-181c hsa-miR-130a* hsa-miR-3065-3p hsa-miR-181a hsa-miR-23c hsa-miR-181d hsa-miR-1297 hsa-miR-23b

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GPSM1 (see all 7) OriGene shRNA RFP: GPSM1 OriGene siRNA: GPSM1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPSM1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for GPSM1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 4): GPSM1 (NM_001145638)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPSM1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GPSM1
		Search LifeMap BioReagents cell lines for GPSM1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPSM1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001965	G-protein alpha-subunit binding	--	--
GO:0005092	GDP-dissociation inhibitor activity	IEA	--
GO:0005515	protein binding	--	--

GPSM1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for GPSM1:

Decreased melanin production

Animal Models:
Mouse knock-out Gpsm1^tm1.1Lajb for GPSM1
8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Gpsm1):

adipose tissue	behavior/neurological	cardiovascular system	growth/size	homeostasis/metabolism
muscle	nervous system	no phenotypic analysis

GPSM1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GPSM1

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/14 Interacting proteins for GPSM1 (Q86YR5^{2, 3} ENSP00000392828⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ZBED1	O96006²^,³, ENSP00000370616⁴	MINT-67402 I2D: score=5 STRING: ENSP00000370616
CCDC158	Q5M9N0²^,³, ENSP00000373566⁴	MINT-66166 I2D: score=4 STRING: ENSP00000373566
DAZAP2	Q15038²^,³, ENSP00000404968⁴	MINT-68318 I2D: score=4 STRING: ENSP00000404968
TRIP13	Q15645²^,³, ENSP00000166345⁴	MINT-66636 I2D: score=5 STRING: ENSP00000166345
USP9X	Q93008³, ENSP00000316357⁴	I2D: score=1 STRING: ENSP00000316357

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0007399	nervous system development	IEA	--
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	IEA	--
GO:0030154	cell differentiation	IEA	--

GPSM1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GPSM1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GPSM1

3 HMDB Compounds for GPSM1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

4 Novoseek chemical compound relationships for GPSM1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
guanosine 5'-o-(3-thiotriphosphate)	56.9	1	10969064 (1)
gdp	41.3	3	11121039 (3)
gtp	39.7	2	11121039 (1), 14530282 (1)
guanine	34.4	1	11121039 (1)

Search CenterWatch for drugs/clinical trials and news about GPSM1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GPSM1 gene (4 alternative transcripts):

NM_001145638.1 NM_001145639.1 NM_001200003.1 NM_015597.4

Unigene Cluster for GPSM1:

G-protein signaling modulator 1

Hs.239370 [show with all ESTs]

Unigene Representative Sequence: NM_001145638

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000392945(uc004chc.3) ENST00000354753 ENST00000392944 ENST00000291775(uc004che.2)

ENST00000440944(uc004chd.2) ENST00000429455(uc011mdu.1 uc022bpn.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): GPSM1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GPSM1
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate GPSM1 (see all 14):
		hsa-miR-181c hsa-miR-130a* hsa-miR-3065-3p hsa-miR-181a hsa-miR-23c hsa-miR-181d hsa-miR-1297 hsa-miR-23b

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GPSM1 (see all 7) OriGene shRNA RFP: GPSM1 OriGene siRNA: GPSM1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPSM1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPSM1 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPSM1 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): GPSM1 (NM_001145638)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPSM1

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat GPSM1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPSM1
		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPSM1

Additional cDNA sequence:

AL117478.1 AY173053.1 BC009943.2 BC009979.1 BC017257.2 BC017353.1 BC048343.1

11 DOTS entries:

DT.112195 DT.75107553 DT.95154432 DT.100715502 DT.95271079 DT.95271082 DT.100028755 DT.100659536

DT.92433935 DT.95271075 DT.97798297

24/152 AceView cDNA sequences (see all 152):

BG056767 AL545250 CR603710 AL043358 CN482348 BM451234 AI276542 AI198064

BX327850 AY173053 BQ878339 AA720922 BC017257 AA479910 BM967301 NM_015597

BQ129314 BM720048 BG741212 BQ925410 BQ434449 BC009943 BM709382 AL548667

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GPSM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTCAATGG

About this image

GPSM1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GPSM1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GPSM1

SOURCE GeneReport for Unigene cluster: Hs.239370

UniProtKB/Swiss-Prot: GPSM1_HUMAN, Q86YR5

Tissue specificity: Expressed in intestinal cells

SABiosciences Custom PCR Arrays for GPSM1

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		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPSM1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPSM1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for GPSM1 gene from 7/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Gpsm1^{1 , 5}	G-protein signalling modulator 1 (AGS3-like, C. elegans)^{1, 5}	85.91(n)¹ 92.56(a)¹		2 (18.73 cM)⁵ 67839¹ NM_153410.5¹ NP_700459.2¹ 26315515⁵
chicken (Gallus gallus)	Aves	GPSM1¹	G-protein signaling modulator 1	73.17(n) 77.73(a)		417132 XM_415415.3 XP_415415.3
lizard (Anolis carolinensis)	Reptilia	GPSM1⁶	--	73(a)	1 ↔ 1	GL344810.1(10251-18733)
African clawed frog (Xenopus laevis)	Amphibia	Xl.8244²	Xenopus laevis transcribed sequence with weak similarity more	76.94(n)		BJ069879.1
zebrafish (Danio rerio)	Actinopterygii	gpsm1b¹	G-protein signaling modulator 1b	70.11(n) 71.59(a)		493623 NM_001007778.1 NP_001007779.1
fruit fly (Drosophila melanogaster)	Insecta	raps⁶	rapsynoid	45(a)	1 → many	3R(23408562-23412098)
worm (Caenorhabditis elegans)	Secernentea	ags-3⁶	Activator of G protein Signalling family member (a...	26(a)	possible ortholog	X(5289696-5298008)

ENSEMBL Gene Tree for GPSM1 (if available)
TreeFam Gene Tree for GPSM1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GPSM1 gene

TTC28² GPSM2² TTC24²

2 SIMAP similar genes for GPSM1 using alignment to 1 protein entry: GPSM1_HUMAN:

GPSM2 PCP2

GPSM1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78751002^1,2	F,	--	108679521(+)	`GCCCTC/TGGGGG`	2	--	us2k¹		1	WA	118
rs35007939^1,2	C,F,H,	--	108679887(+)	`GTGCCC/TGAAGC`	2	--	us2k¹		7	NS NA	832
rs73670225^1,2	C,	--	108680173(+)	`CAGCCC/TGGGGC`	2	--	us2k¹		2	WA	120
rs72775735^1,2	C,F,	--	108680943(+)	`TAGGAC/ACCCCG`	2	--	us2k¹		2	WA NA	238
rs62579957^1,2	C,	--	108681658(+)	`GGGCCA/GGGGCC`	2	--	int¹		1	NA	2
rs62579958^1,2		--	108681675(+)	`GGGGCT/CGGGGC`	2	--	int¹		1	NA	2
rs35813596^1,2	C,	--	108682049(+)	`TCCACG/CAGCCC`	2	--	int¹		4	NA CSA WA	241
rs35319705^1,2	C,	--	108682211(+)	`GTGGCG/ATGCCT`	2	--	int¹		1	NA	2
rs34242208^1,2	C,	--	108682246(+)	`CAGGGG/TCTGCC`	2	--	int¹		3	NA WA	240
rs80284195^1,2		--	108682324(+)	`CCACAC/TGAGCG`	2	--	int¹		2	CSA WA	120

HapMap Linkage Disequilibrium report for GPSM1 (139221932 - 139254057 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for GPSM1
2 CNVs: 3785 0133

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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GPSM1 for disorders           About GeneDecksing

OMIM gene information: 609491    OMIM disorders: --

7 diseases for GPSM1:    About MalaCards

aicardi-goutieres syndrome hepatitis b periodontitis hepatitis

cerebritis neuronitis drug addiction

1 Novoseek disease relationship for GPSM1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
colon cancer	19.6	1	15488168 (1)

Human Genome Epidemiology (HuGE) Navigator: GPSM1 (1 document)

Export disorders for GPSM1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GPSM1 gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with GPSM1)

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The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells. (PubMed id 12642577)^{1, 2, 9} Pattingre S.... Codogno P. (2003)
Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3. (PubMed id 10969064)^{1, 3, 9} Peterson Y.K....Lanier S.M. (2000)
Identification of a truncated form of the G-protein regulator AGS3 in heart that lacks the tetratricopeptide repeat domains. (PubMed id 11278352)^{1, 3, 9} Pizzinat N....Lanier S.M. (2001)
The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins. (PubMed id 18566450)^{1, 2} An N....Lanier S.M. (2008)
Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3. (PubMed id 16458856)^{1, 2} Izaki T.... Sumimoto H. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
AGS3 inhibits GDP dissociation from galpha subunits of the Gi family and rhodopsin-dependent activation of transducin. (PubMed id 11024022)^{1, 2} Natochin M....Artemyev N.O. (2000)
Distribution of activator of G-protein signaling 3 wi thin the aggresomal pathway: role of specific residues in the tetratricopeptide repeat domain and differential regulation by the AGS3 binding partners Gi(alph a) and mammalian inscuteable. (PubMed id 20065032)^{1, 9} Vural A....Lanier S.M. (2010)
A specific role of AGS3 in the surface expression of plasma membrane proteins. (PubMed id 17991770)^{1, 9} Groves B....Ma D. (2007)
An inhibitory role of the G-protein regulator AGS3 in mTOR-dependent macroautophagy. (PubMed id 20126274)^{1, 9} Groves B....Ma D. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 26086	HGNC: 17858	AceView: GPSM1	Ensembl:ENSG00000160360	euGenes: HUgn26086
ECgene: GPSM1	H-InvDB: GPSM1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GPSM1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for GPSM1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for GPSM1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GPSM1 gene:
Search GeneIP for patents involving GPSM1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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