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Aliases for GPS2 Gene

Aliases for GPS2 Gene

  • G Protein Pathway Suppressor 2 2 3 5
  • GPS-2 3 4
  • AMF-1 3

External Ids for GPS2 Gene

Previous GeneCards Identifiers for GPS2 Gene

  • GC17M007614
  • GC17M007945
  • GC17M007158
  • GC17M007416
  • GC17M007156
  • GC17M007215
  • GC17M007112

Summaries for GPS2 Gene

Entrez Gene Summary for GPS2 Gene

  • This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPS2 Gene

GPS2 (G Protein Pathway Suppressor 2) is a Protein Coding gene. Diseases associated with GPS2 include Timothy Grass Allergy. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chromatin organization. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity and GTPase inhibitor activity.

UniProtKB/Swiss-Prot for GPS2 Gene

  • Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction (PubMed:8943324). May act as a regulator of adipogenisis (By similarity).

Gene Wiki entry for GPS2 Gene

Additional gene information for GPS2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPS2 Gene

Genomics for GPS2 Gene

GeneHancer (GH) Regulatory Elements for GPS2 Gene

Promoters and enhancers for GPS2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I007312 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 555.4 +1.0 1019 4 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 GPS2 GC17M007314 EIF5A ACAP1 SLC2A4 ENSG00000202251 CLDN7 CTDNEP1 ELP5 GABARAP
GH17I007571 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE dbSUPER 24.2 -262.6 -262595 14.2 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 SNORD10 EIF4A1 CD68 GC17P007735 GC17P007737 GC17P007739 GC17P007742 PIR46508 SNORA67 MPDU1
GH17I008172 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 24.1 -859.4 -859403 5.2 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF416 LOC105371520 GC17M008511 SNORD118 TMEM107 DVL2 CTC1 CNTROB POLR2A WRAP53 SNORD10
GH17I008149 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.8 -841.8 -841755 16 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 PER1 VAMP2 ENSG00000265749 CYB5D1 CTC1 DVL2 PFAS CNTROB SENP3 POLR2A
GH17I007833 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.8 -524.2 -524165 12.5 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 KDM6B DVL2 PFAS CTC1 WRAP53 CNTROB POLR2A SNORD10 SNORA48 PER1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPS2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPS2 gene promoter:

Genomic Locations for GPS2 Gene

Genomic Locations for GPS2 Gene
chr17:7,311,324-7,315,564
(GRCh38/hg38)
Size:
4,241 bases
Orientation:
Minus strand
chr17:7,214,643-7,218,883
(GRCh37/hg19)

Genomic View for GPS2 Gene

Genes around GPS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPS2 Gene

Proteins for GPS2 Gene

  • Protein details for GPS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13227-GPS2_HUMAN
    Recommended name:
    G protein pathway suppressor 2
    Protein Accession:
    Q13227
    Secondary Accessions:
    • B4DXA1
    • Q6FHM8

    Protein attributes for GPS2 Gene

    Size:
    327 amino acids
    Molecular mass:
    36689 Da
    Quaternary structure:
    • Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2 (PubMed:11931768). Interacts with ANKRD26 (PubMed:22666460).
    SequenceCaution:
    • Sequence=CAB75677.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GPS2 Gene

    Alternative splice isoforms for GPS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPS2 Gene

Post-translational modifications for GPS2 Gene

No Post-translational modifications

Other Protein References for GPS2 Gene

No data available for DME Specific Peptides for GPS2 Gene

Domains & Families for GPS2 Gene

Gene Families for GPS2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for GPS2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GPS2: view

No data available for UniProtKB/Swiss-Prot for GPS2 Gene

Function for GPS2 Gene

Molecular function for GPS2 Gene

UniProtKB/Swiss-Prot Function:
Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction (PubMed:8943324). May act as a regulator of adipogenisis (By similarity).

Phenotypes From GWAS Catalog for GPS2 Gene

Gene Ontology (GO) - Molecular Function for GPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IDA 11931768
GO:0005095 GTPase inhibitor activity TAS 8943324
GO:0005515 protein binding IPI 11931768
GO:0030332 cyclin binding IPI 15159402
genes like me logo Genes that share ontologies with GPS2: view

Phenotypes for GPS2 Gene

MGI mutant phenotypes for GPS2:
inferred from 1 alleles
GenomeRNAi human phenotypes for GPS2:
genes like me logo Genes that share phenotypes with GPS2: view

Animal Models for GPS2 Gene

MGI Knock Outs for GPS2:

Clone Products

  • Addgene plasmids for GPS2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPS2 Gene

Localization for GPS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPS2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPS2 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0017053 transcriptional repressor complex IDA 12628926
genes like me logo Genes that share ontologies with GPS2: view

Pathways & Interactions for GPS2 Gene

genes like me logo Genes that share pathways with GPS2: view

Pathways by source for GPS2 Gene

1 KEGG pathway for GPS2 Gene

Gene Ontology (GO) - Biological Process for GPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 11931768
GO:0000188 inactivation of MAPK activity TAS 8943324
GO:0007049 cell cycle TAS 8943324
GO:0007254 JNK cascade TAS 8943324
GO:0034260 negative regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with GPS2: view

No data available for SIGNOR curated interactions for GPS2 Gene

Drugs & Compounds for GPS2 Gene

No Compound Related Data Available

Transcripts for GPS2 Gene

Unigene Clusters for GPS2 Gene

G protein pathway suppressor 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for GPS2

Alternative Splicing Database (ASD) splice patterns (SP) for GPS2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
SP1: - -
SP2:
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 20b ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b · 24c · 24d ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b ^ 29a · 29b · 29c ^ 30a · 30b
SP1: - -
SP2: - - -
SP3:
SP4:
SP5: -
SP6: - - - -
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for GPS2 Gene

GeneLoc Exon Structure for
GPS2
ECgene alternative splicing isoforms for
GPS2

Expression for GPS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPS2 Gene

Protein differential expression in normal tissues from HIPED for GPS2 Gene

This gene is overexpressed in Ovary (39.6), CD4 Tcells (8.7), and Spleen (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPS2 Gene



NURSA nuclear receptor signaling pathways regulating expression of GPS2 Gene:

GPS2

SOURCE GeneReport for Unigene cluster for GPS2 Gene:

Hs.438219

mRNA Expression by UniProt/SwissProt for GPS2 Gene:

Q13227-GPS2_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for GPS2 Gene

  • Nervous system(3.3)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with GPS2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPS2 Gene

Orthologs for GPS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPS2 33 34
  • 99.49 (n)
oppossum
(Monodelphis domestica)
Mammalia GPS2 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPS2 33 34
  • 91.54 (n)
mouse
(Mus musculus)
Mammalia Gps2 33 16 34
  • 91.13 (n)
rat
(Rattus norvegicus)
Mammalia Gps2 33
  • 91.13 (n)
dog
(Canis familiaris)
Mammalia GPS2 33 34
  • 90.01 (n)
lizard
(Anolis carolinensis)
Reptilia GPS2 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gps2 33
  • 69.33 (n)
Str.4949 33
African clawed frog
(Xenopus laevis)
Amphibia gps2-prov 33
zebrafish
(Danio rerio)
Actinopterygii gps2 33 34
  • 66.25 (n)
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2137 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9458 34
  • 33 (a)
OneToOne
Species where no ortholog for GPS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPS2 Gene

ENSEMBL:
Gene Tree for GPS2 (if available)
TreeFam:
Gene Tree for GPS2 (if available)

Paralogs for GPS2 Gene

(1) SIMAP similar genes for GPS2 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for GPS2 Gene

genes like me logo Genes that share paralogs with GPS2: view

No data available for Paralogs for GPS2 Gene

Variants for GPS2 Gene

Sequence variations from dbSNP and Humsavar for GPS2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000263544 -- 7,315,770(-) G/A upstream_transcript_variant
rs1000454241 -- 7,315,448(-) G/A upstream_transcript_variant
rs1000600861 -- 7,314,847(-) C/T intron_variant
rs1000800737 -- 7,315,548(-) T/G upstream_transcript_variant
rs1003523035 -- 7,313,204(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPS2 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
esv2665200 CNV deletion 23128226
esv3639865 CNV loss 21293372
esv3639866 CNV gain 21293372
nsv1963 CNV deletion 18451855
nsv457659 CNV loss 19166990
nsv509650 CNV insertion 20534489
nsv574322 CNV loss 21841781
nsv952118 CNV deletion 24416366

Variation tolerance for GPS2 Gene

Residual Variation Intolerance Score: 17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPS2 Gene

Disorders for GPS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPS2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
timothy grass allergy
- elite association - COSMIC cancer census association via MalaCards
Search GPS2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPS2

genes like me logo Genes that share disorders with GPS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPS2 Gene

Publications for GPS2 Gene

  1. Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells. (PMID: 8943324) Spain BH … Colicelli J (Molecular and cellular biology 1996) 2 3 4 58
  2. ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells. (PMID: 22666460) Liu XF … Pastan I (PloS one 2012) 3 4 58
  3. G protein pathway suppressor 2 (GPS2) is a transcriptional corepressor important for estrogen receptor alpha-mediated transcriptional regulation. (PMID: 19858209) Cheng X … Kao HY (The Journal of biological chemistry 2009) 3 22 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for GPS2 Gene

  • Addgene plasmids for GPS2

Sources for GPS2 Gene