External Ids for GPS2 Gene
Previous GeneCards Identifiers for GPS2 Gene
This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]
GeneCards Summary for GPS2 Gene
GPS2 (G Protein Pathway Suppressor 2) is a Protein Coding gene. Diseases associated with GPS2 include Timothy Grass Allergy. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chromatin organization. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity and GTPase inhibitor activity.
UniProtKB/Swiss-Prot for GPS2 Gene
Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction (PubMed:8943324). May act as a regulator of adipogenisis (By similarity).