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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPS2 Gene

protein-coding   GIFtS: 52
GCID: GC17M007215

G Protein Pathway Suppressor 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
G Protein Pathway Suppressor 21 2
GPS-22 3
AMF-12

External Ids:    HGNC: 45501   Entrez Gene: 28742   Ensembl: ENSG000001325227   OMIM: 6019355   UniProtKB: Q132273   

Export aliases for GPS2 gene to outside databases

Previous GC identifers: GC17M007614 GC17M007945 GC17M007158 GC17M007416 GC17M007156 GC17M007112


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GPS2 Gene:
This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When
overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere
with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an
integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was
shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an
alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. (provided by RefSeq,
Jul 2008)

GeneCards Summary for GPS2 Gene: 
GPS2 (G protein pathway suppressor 2) is a protein-coding gene. Diseases associated with GPS2 include thyroiditis, and melanoma. GO annotations related to this gene include GTPase inhibitor activity and transcription corepressor activity.

UniProtKB/Swiss-Prot: GPS2_HUMAN, Q13227
Function: Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction

Gene Wiki entry for GPS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPS2 gene promoter:
         COUP-TF1   AP-1   ATF-2   COUP   HNF-4alpha2   HNF-4alpha1   COUP-TF   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GPS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for GPS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

GPS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPS2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007215:  view genomic region     (about GC identifiers)

Start:
7,214,643 bp from pter      End:
7,218,883 bp from pter
Size:
4,241 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GPS2_HUMAN, Q13227 (See protein sequence)
Recommended Name: G protein pathway suppressor 2  
Size: 327 amino acids; 36689 Da
Subunit: Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A
and GPS2
Sequence caution: Sequence=CAB75677.2; Type=Erroneous translation; Note=Wrong choice of frame;
1 PDB 3D structure from and Proteopedia for GPS2:
2L5G (3D)    
Secondary accessions: Q6FHM8

Explore the universe of human proteins at neXtProt for GPS2: NX_Q13227

Explore proteomics data for GPS2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13227

  • GPS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GPS2 Protein Expression
    REFSEQ proteins: NP_004480.1  
    ENSEMBL proteins: 
     ENSP00000460836   ENSP00000458837   ENSP00000379841   ENSP00000459357   ENSP00000370104  
     ENSP00000461624   ENSP00000438697  

    Human Recombinant Protein Products for GPS2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GPS2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for GPS2
    GenScript Custom Purified and Recombinant Proteins Services for GPS2
    Novus Biologicals GPS2 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GPS2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0017053transcriptional repressor complex IDA12628926

    GPS2 for ontologies           About GeneDecksing



    GPS2 Antibody Products: 
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    Abcam antibodies for GPS2
    Cloud-Clone Corp. Antibodies for GPS2 
    ThermoFisher Antibodies for GPS2
    LSBio Antibodies in human, mouse, rat for GPS2 

    Assay Products for GPS2: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GPS2 
    Cloud-Clone Corp. CLIAs for GPS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026094 GPS2

    Graphical View of Domain Structure for InterPro Entry Q13227

    ProtoNet protein and cluster: Q13227


    GPS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPS2_HUMAN, Q13227
    Function: Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity IDA11931768
    GO:0005095GTPase inhibitor activity TAS8943324
    GO:0005515protein binding IPI11931768
         
    GPS2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GPS2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GPS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GPS2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GPS2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GPS2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GPS2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GPS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPS2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for GPS2
    Sirion Biotech Customized adenovirus for overexpression of GPS2

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GPS2 (see all 7)
    OriGene ORF clones in mouse, rat for GPS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GPS2 (NM_004489)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPS2
    Sirion Biotech Customized lentivirus for stable overexpression of GPS2 
                         Customized lentivirus expression plasmids for stable overexpression of GPS2 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for GPS2
    Search LifeMap BioReagents cell lines for GPS2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPS2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GPS2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1HTLV-I infection
    HTLV-I infection

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for GPS2):
        HTLV-I infection


    GPS2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GPS2

    5/588 Interacting proteins for GPS2 (Q132271, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 588)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K7CLP570771, 2, 3EBI-713355,EBI-748831 MINT-68092 I2D: score=6 
    CHD3Q128732, 3MINT-64129 I2D: score=5 
    GOLGA2Q083792, 3MINT-64127 I2D: score=5 
    PBKQ96KB52, 3MINT-65224 I2D: score=5 
    SETDB1Q150472, 3MINT-64128 I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA11931768
    GO:0000188inactivation of MAPK activity TAS8943324
    GO:0007049cell cycle TAS8943324
    GO:0007254JNK cascade TAS8943324
    GO:0046329negative regulation of JNK cascade IDA11931768

    GPS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GPS2

    Search CenterWatch for drugs/clinical trials and news about GPS2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GPS2 gene: 
    NM_004489.4  

    Unigene Cluster for GPS2:

    G protein pathway suppressor 2
    Hs.438219  [show with all ESTs]
    Unigene Representative Sequence: BC103902
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000570780 ENST00000573807 ENST00000572172 ENST00000571569(uc002gfw.1)
    ENST00000573684 ENST00000389167 ENST00000574458 ENST00000380728 ENST00000571697
    ENST00000577040 ENST00000572363 ENST00000571098 ENST00000573059 ENST00000572707
    ENST00000571695 ENST00000574201 ENST00000391950
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GPS2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GPS2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GPS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPS2
    Clone
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    OriGene clones in human, mouse for GPS2 (see all 7)
    OriGene ORF clones in mouse, rat for GPS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GPS2 (NM_004489)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPS2
    Sirion Biotech Customized lentivirus for stable overexpression of GPS2 
                         Customized lentivirus expression plasmids for stable overexpression of GPS2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GPS2
    OriGene qSTAR qPCR primer pairs in human, mouse for GPS2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GPS2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPS2

    Additional mRNA sequence: 

    AK301877.1 BC013652.1 BC103901.1 BC103902.1 BC103903.1 BC107738.1 BT006998.1 CR541723.1 
    CR541750.1 U28963.1 

    24 DOTS entries:

    DT.214813  DT.95160654  DT.121004049  DT.100825984  DT.100825989  DT.100683224  DT.75110469  DT.92441596 
    DT.100825986  DT.121004050  DT.95160647  DT.95256955  DT.121004149  DT.95085354  DT.100030438  DT.121004020 
    DT.92441598  DT.100059680  DT.100670192  DT.101987519  DT.91651453  DT.92369501  DT.92406983  DT.95279163 

    24/392 AceView cDNA sequences (see all 392):

    BM997954 CN478702 AA256431 BC014192 BE888169 AA744026 CA866696 AB058690 
    BQ710279 BI761134 AI498420 BM711044 AI287585 CK430714 BM558413 BQ888998 
    AW340974 BM828588 BQ686133 BM904318 AX747847 BM545598 BM559396 AL833570 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for GPS2 (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
    SP1:                                                              -                       -                                                                     
    SP2:                                                                                                                                                            
    SP3:                                                              -           -           -                                                                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20b ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b · 24c · 24d ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b ^ 29a · 29b · 29c ^ 30a · 30b
    SP1:                                      -                                                     -                                       
    SP2:                                      -     -                                               -                                       
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:                                                                                            -                                       


    ECgene alternative splicing isoforms for GPS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCCCCAGG
    GPS2 Expression
    About this image


    See GPS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GPS2

    SOURCE GeneReport for Unigene cluster: Hs.438219

    UniProtKB/Swiss-Prot: GPS2_HUMAN, Q13227
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for GPS2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GPS2 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gps21 , 5 G protein pathway suppressor 21, 5 91.13(n)1
    97.55(a)1
      11 (42.92 cM)5
    563101  NM_019726.31  NP_062700.21 
     699138885 
    lizard
    (Anolis carolinensis)
    Reptilia GPS26
    Uncharacterized protein
    88(a)
    1 ↔ 1
    GL344643.1(14658-24498)
    African clawed frog
    (Xenopus laevis)
    Amphibia gps2-prov2 G protein pathway suppressor 2 78.8(n)    BC055966.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC054126.12   -- 76.71(n)   393948  BC054126.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG170026
    --
    18(a)
    1 ↔ 1
    2R(2873568-2876427)


    ENSEMBL Gene Tree for GPS2 (if available)
    TreeFam Gene Tree for GPS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GPS2 gene
    1 SIMAP similar gene for GPS2 using alignment to 10 protein entries:     GPS2_HUMAN (see all proteins):
    NEURL4

    GPS2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for GPS2
    PGOHUM00000238295 PGOHUM00000235944


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/130 SNPs in GPS2 are shown (see all 130)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0219724
    ----see VAR_0219722 T A mis40--------
    rs1997122121,2
    --7216313(+) TGTAGA/GGATTC 1 -- int10--------
    rs2011623241,2
    C--7216375(+) ACAGGG/CAGCTG 2 /L syn11Minor allele frequency- C:0.00EU 989
    rs1395746771,2
    C--7216381(+) AGCTGG/CGGGGA 2 /P syn11Minor allele frequency- C:0.00NA 4244
    rs1920502251,2
    C--7216434(+) GGGGCA/GCAGAG 2 R C mis10--------
    rs2016305511,2
    --7216504(+) CTAACC/TCTGAC 1 -- int10--------
    rs22709811,2
    C,F,H--7216540(-) GGCTTC/TTCCGA 2 F syn1 ese323Minor allele frequency- T:0.14EA MN NS NA WA EU 5398
    rs1442094481,2
    C--7216564(+) GCATGT/CTCCAT 2 /E syn11Minor allele frequency- C:0.00EU 1323
    rs1479832051,2
    F--7216579(+) TTTTGC/TAAGGA 2 L syn11Minor allele frequency- T:0.00NA 4552
    rs2006208181,2
    C--7216639(+) GAGATA/GAGAAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for GPS2 (7214643 - 7218883 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for GPS2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422288CNV Deletion17116639
    esv2665200CNV Deletion23128226
    nsv509650CNV Insertion20534489
    nsv907641CNV Loss21882294
    nsv907637CNV Loss21882294
    dgv3053n71CNV Loss21882294
    nsv907642CNV Loss21882294
    nsv457659CNV Loss19166990
    nsv1963CNV Loss18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601935    OMIM disorders: --

    3 diseases for GPS2:    About MalaCards
    thyroiditis    melanoma    hepatitis


    GPS2 for disorders           About GeneDecksing


    Export disorders for GPS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GPS2 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with GPS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells. (PubMed id 8943324)1, 2, 3 Spain B.H.... Colicelli J. (1996)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. (PubMed id 11931768)1, 2 Zhang J....Roeder R.G. (2002)
    4. AMF1 (GPS2) modulates p53 transactivation. (PubMed id 11486030)1, 9 Peng Y.C....Androphy E.J. (2001)
    5. G protein pathway suppressor 2 (GPS2) is a transcript ional corepressor important for estrogen receptor alpha-mediated transcriptiona l regulation. (PubMed id 19858209)1, 9 Cheng X. and Kao H.Y. (2009)
    6. AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins. (PubMed id 10846067)1, 9 Peng Y.C....Androphy E.J. (2000)
    7. SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation. (PubMed id 23221346)1 Toubal A....Venteclef N. (2013)
    8. The functional interactome landscape of the human hist one deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (2013)
    9. Vif hijacks CBF-b to degrade APOBEC3G and promote HIV- 1 infection. (PubMed id 22190037)1 Jager S....Krogan N.J. (2012)
    10. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2874 HGNC: 4550 AceView: GPS2 Ensembl:ENSG00000132522 euGenes: HUgn2874
    ECgene: GPS2 Kegg: 2874 H-InvDB: GPS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GPS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GPS2 gene:
    Search GeneIP for patents involving GPS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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