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GPS2 Gene

protein-coding   GIFtS: 52
GCID: GC17M007215

G Protein Pathway Suppressor 2

  Search for GPS2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
G Protein Pathway Suppressor 21 2
GPS-22 3
AMF-12

External Ids:    HGNC: 45501   Entrez Gene: 28742   Ensembl: ENSG000001325227   OMIM: 6019355   UniProtKB: Q132273   
ORGUL members:         

Export aliases for GPS2 gene to outside databases

Previous GC identifers: GC17M007614 GC17M007945 GC17M007158 GC17M007416 GC17M007156 GC17M007112


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GPS2 Gene:
This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When
overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere
with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an
integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was
shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an
alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. (provided by RefSeq,
Jul 2008)

GeneCards Summary for GPS2 Gene:
GPS2 (G protein pathway suppressor 2) is a protein-coding gene. GO annotations related to this gene include GTPase inhibitor activity and transcription corepressor activity.

UniProtKB/Swiss-Prot: GPS2_HUMAN, Q13227
Function: Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction

Gene Wiki entry for GPS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPS2 gene promoter:
         COUP-TF1   AP-1   ATF-2   COUP   HNF-4alpha2   HNF-4alpha1   COUP-TF   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GPS2 promoter sequence
   Search Chromatin IP Primers for GPS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

GPS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPS2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007215:  view genomic region     (about GC identifiers)

Start:
7,214,643 bp from pter      End:
7,218,883 bp from pter
Size:
4,241 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GPS2_HUMAN, Q13227 (See protein sequence)
Recommended Name: G protein pathway suppressor 2  
Size: 327 amino acids; 36689 Da
Subunit: Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A
and GPS2
Sequence caution: Sequence=CAB75677.2; Type=Erroneous translation; Note=Wrong choice of frame;
1 PDB 3D structure from and Proteopedia for GPS2:
2L5G (3D)    
Secondary accessions: Q6FHM8

Explore the universe of human proteins at neXtProt for GPS2: NX_Q13227

Explore proteomics data for GPS2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GPS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004480.1  
    ENSEMBL proteins: 
     ENSP00000460836   ENSP00000458837   ENSP00000379841   ENSP00000459357   ENSP00000370104  
     ENSP00000461624   ENSP00000438697  

    GPS2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for GPS2
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    Novus Biologicals GPS2 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GPS2

     
    Search eBioscience for Proteins for GPS2 

    GPS2 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for GPS2

    GPS2 Assay Products:

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    Cloud-Clone Corp. ELISAs for GPS2
    Cloud-Clone Corp. CLIAs for GPS2
    Search eBioscience for ELISAs for GPS2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026094 GPS2

    Graphical View of Domain Structure for InterPro Entry Q13227

    ProtoNet protein and cluster: Q13227


    Find genes that share domains with GPS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPS2_HUMAN, Q13227
    Function: Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity IDA11931768
    GO:0005095GTPase inhibitor activity TAS8943324
    GO:0005515protein binding IPI11931768
         
    Find genes that share ontologies with GPS2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GPS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GPS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GPS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GPS2

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for GPS2
    Predesigned siRNA for gene silencing in human, mouse, rat GPS2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for GPS2

    Clone
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    OriGene clones in human, mouse for GPS2 (see all 6)
    OriGene ORF clones in mouse, rat for GPS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GPS2 (NM_004489)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPS2

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0017053transcriptional repressor complex IDA12628926

    Find genes that share ontologies with GPS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GPS2 About    
    See pathways by source

    SuperPathContained pathways About
    1HTLV-I infection
    HTLV-I infection


    Find genes that share SuperPaths with GPS2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for GPS2):
        HTLV-I infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GPS2
    Interactions:

        GeneGlobe Interaction Network for GPS2

    Selected Interacting proteins for GPS2 (Q132271, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 588)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K7CLP570771, 2, 3EBI-713355,EBI-748831 MINT-68092 I2D: score=6 
    CHD3Q128732, 3MINT-64129 I2D: score=5 
    GOLGA2Q083792, 3MINT-64127 I2D: score=5 
    PBKQ96KB52, 3MINT-65224 I2D: score=5 
    SETDB1Q150472, 3MINT-64128 I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA11931768
    GO:0000188inactivation of MAPK activity TAS8943324
    GO:0007049cell cycle TAS8943324
    GO:0007254JNK cascade TAS8943324
    GO:0046329negative regulation of JNK cascade IDA11931768

    Find genes that share ontologies with GPS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPS2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GPS2 gene: 
    NM_004489.4  

    Unigene Cluster for GPS2:

    G protein pathway suppressor 2
    Hs.438219  [show with all ESTs]
    Unigene Representative Sequence: BC103902
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000570780 ENST00000573807 ENST00000572172 ENST00000571569(uc002gfw.1)
    ENST00000573684 ENST00000389167 ENST00000574458 ENST00000380728 ENST00000571697
    ENST00000577040 ENST00000572363 ENST00000571098 ENST00000573059 ENST00000572707
    ENST00000571695 ENST00000574201 ENST00000391950
    miRNA
    Products:
         
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    Search for qRT-PCR Assays for microRNAs that regulate GPS2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for GPS2
    Predesigned siRNA for gene silencing in human, mouse, rat GPS2
    Clone
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    OriGene clones in human, mouse for GPS2 (see all 6)
    OriGene ORF clones in mouse, rat for GPS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GPS2 (NM_004489)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPS2
    Primer
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    OriGene qPCR primer pairs and template standards for GPS2
    OriGene qSTAR qPCR primer pairs in human, mouse for GPS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GPS2
      QuantiTect SYBR Green Assays in human, mouse, rat GPS2
      QuantiFast Probe-based Assays in human, mouse, rat GPS2

    Additional mRNA sequence: 

    AK301877.1 BC013652.1 BC103901.1 BC103902.1 BC103903.1 BC107738.1 BT006998.1 CR541723.1 
    CR541750.1 U28963.1 

    24 DOTS entries:

    DT.214813  DT.95160654  DT.121004049  DT.100825984  DT.100825989  DT.100683224  DT.75110469  DT.92441596 
    DT.100825986  DT.121004050  DT.95160647  DT.95256955  DT.121004149  DT.95085354  DT.100030438  DT.121004020 
    DT.92441598  DT.100059680  DT.100670192  DT.101987519  DT.91651453  DT.92369501  DT.92406983  DT.95279163 

    Selected AceView cDNA sequences (see all 392):

    AI498420 AL042960 AX747847 BM998543 AA744026 BI761134 BM811042 T34812 
    NM_032442 BQ064836 BQ060827 BU521100 BC014192 BM052972 AI459479 CA866696 
    AL122080 BQ877093 AA256431 CA393786 BQ888998 CN478702 BQ636520 BM558413 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GPS2 (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
    SP1:                                                              -                       -                                                                     
    SP2:                                                                                                                                                            
    SP3:                                                              -           -           -                                                                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20b ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b · 24c · 24d ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b ^ 29a · 29b · 29c ^ 30a · 30b
    SP1:                                      -                                                     -                                       
    SP2:                                      -     -                                               -                                       
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:                                                                                            -                                       


    ECgene alternative splicing isoforms for GPS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCCCCAGG
    GPS2 Expression
    About this image

    GPS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.438219

    UniProtKB/Swiss-Prot: GPS2_HUMAN, Q13227
    Tissue specificity: Widely expressed

        Custom PCR Arrays for GPS2
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    QuantiFast Probe-based Assays in human, mouse, rat GPS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GPS2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gps21 , 5 G protein pathway suppressor 21, 5 91.13(n)1
    97.55(a)1
      11 (42.92 cM)5
    563101  NM_019726.31  NP_062700.21 
     699138885 
    lizard
    (Anolis carolinensis)
    Reptilia GPS26
    G protein pathway suppressor 2
    89(a)
    1 ↔ 1
    GL344643.1(14658-24498)
    African clawed frog
    (Xenopus laevis)
    Amphibia gps2-prov2 G protein pathway suppressor 2 78.8(n)    BC055966.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC054126.12   -- 76.71(n)   393948  BC054126.1 


    ENSEMBL Gene Tree for GPS2 (if available)
    TreeFam Gene Tree for GPS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GPS2 gene
    1 SIMAP similar gene for GPS2 using alignment to 9 protein entries:     GPS2_HUMAN (see all proteins):
    NEURL4

    Find genes that share paralogs with GPS2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for GPS2
    PGOHUM00000238295 PGOHUM00000235944


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GPS2 (see all 130)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1997122121,2
    --7216313(+) TGTAGA/GGATTC 1 -- int10--------
    rs2011623241,2
    C--7216375(+) ACAGGG/CAGCTG 2 /L syn11Minor allele frequency- C:0.00EU 989
    rs1395746771,2
    C--7216381(+) AGCTGG/CGGGGA 2 /P syn11Minor allele frequency- C:0.00NA 4244
    rs1920502251,2
    C--7216434(+) GGGGCA/GCAGAG 2 R C mis10--------
    rs2016305511,2
    --7216504(+) CTAACC/TCTGAC 1 -- int10--------
    rs22709811,2
    C,F,H--7216540(-) GGCTTC/TTCCGA 2 F syn1 ese323Minor allele frequency- T:0.14EA MN NS NA WA EU 5398
    rs1442094481,2
    C--7216564(+) GCATGT/CTCCAT 2 /E syn11Minor allele frequency- C:0.00EU 1323
    rs1479832051,2
    F--7216579(+) TTTTGC/TAAGGA 2 L syn11Minor allele frequency- T:0.00NA 4552
    rs2006208181,2
    C--7216639(+) GAGATA/GAGAAT 1 -- int10--------
    rs1416499361,2
    F--7216727(+) CCATGC/TACAGC 2 V syn11Minor allele frequency- T:0.00NA 4552

    HapMap Linkage Disequilibrium report for GPS2 (7214643 - 7218883 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for GPS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422288CNV Deletion17116639
    esv2665200CNV Deletion23128226
    nsv509650CNV Insertion20534489
    nsv907641CNV Loss21882294
    nsv907637CNV Loss21882294
    dgv3053n71CNV Loss21882294
    nsv907642CNV Loss21882294
    nsv457659CNV Loss19166990
    nsv1963CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601935    OMIM disorders: --


    Find genes that share disorders with GPS2           About GenesLikeMe


    Export disorders for GPS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPS2 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with GPS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells. (PubMed id 8943324)1, 2, 3 Spain B.H.... Colicelli J. (Mol. Cell. Biol. 1996)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. (PubMed id 11931768)1, 2 Zhang J.... Roeder R.G. (Mol. Cell 2002)
    4. AMF1 (GPS2) modulates p53 transactivation. (PubMed id 11486030)1, 9 Peng Y.C....Androphy E.J. (Mol. Cell. Biol. 2001)
    5. G protein pathway suppressor 2 (GPS2) is a transcriptional corepressor important for estrogen receptor alpha-mediated transcriptional regulation. (PubMed id 19858209)1, 9 Cheng X. and Kao H.Y. (J. Biol. Chem. 2009)
    6. AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins. (PubMed id 10846067)1, 9 Peng Y.C....Androphy E.J. (J. Virol. 2000)
    7. SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation. (PubMed id 23221346)1 Toubal A....Venteclef N. (J. Clin. Invest. 2013)
    8. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    9. Vif hijacks CBF-I^ to degrade APOBEC3G and promote HIV-1 infection. (PubMed id 22190037)1 JAoger S....Krogan N.J. (Nature 2012)
    10. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2874 HGNC: 4550 AceView: GPS2 Ensembl:ENSG00000132522 euGenes: HUgn2874
    ECgene: GPS2 Kegg: 2874 H-InvDB: GPS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GPS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GPS2 gene:
    Search GeneIP for patents involving GPS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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