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Aliases for GPS1 Gene

Aliases for GPS1 Gene

  • G Protein Pathway Suppressor 1 2 3 4
  • JAB1-Containing Signalosome Subunit 1 3 4
  • COP9 Signalosome Subunit 1 2 3
  • Signalosome Subunit 1 3 4
  • COPS1 3 4
  • GPS-1 3 4
  • CSN1 3 4
  • SGN1 3 4
  • COP9 Signalosome Complex Subunit 1 3
  • Protein MFH 4

External Ids for GPS1 Gene

Summaries for GPS1 Gene

Entrez Gene Summary for GPS1 Gene

  • This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPS1 Gene

GPS1 (G Protein Pathway Suppressor 1) is a Protein Coding gene. GO annotations related to this gene include GTPase inhibitor activity. An important paralog of this gene is PSMD6.

UniProtKB/Swiss-Prot for GPS1 Gene

  • Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

Gene Wiki entry for GPS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPS1 Gene

Genomics for GPS1 Gene

Genomic Location for GPS1 Gene

Start:
82,050,691 bp from pter
End:
82,057,470 bp from pter
Size:
6,780 bases
Orientation:
Plus strand

Genomic View for GPS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPS1 Gene

Regulatory Elements for GPS1 Gene

Proteins for GPS1 Gene

  • Protein details for GPS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13098-CSN1_HUMAN
    Recommended name:
    COP9 signalosome complex subunit 1
    Protein Accession:
    Q13098
    Secondary Accessions:
    • Q8NA10
    • Q9BWL1

    Protein attributes for GPS1 Gene

    Size:
    491 amino acids
    Molecular mass:
    55537 Da
    Quaternary structure:
    • Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS2, COPS3, COPS4 and COPS5. Interacts directly with inositol kinase ITPK1. Interacts with CAPN8 (By similarity).
    SequenceCaution:
    • Sequence=AAC50906.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GPS1 Gene

    Alternative splice isoforms for GPS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPS1 Gene

Proteomics data for GPS1 Gene at MOPED

Post-translational modifications for GPS1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys183, Lys224, Lys248, Lys268, Lys422, Lys438, Lys444, and Lys467

No data available for DME Specific Peptides for GPS1 Gene

Domains for GPS1 Gene

Suggested Antigen Peptide Sequences for GPS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13098

UniProtKB/Swiss-Prot:

CSN1_HUMAN
Domain:
  • The PCI domain is necessary and sufficient for the interactions with other CSN subunits of the complex. Mediates the interaction with CAPN8 (By similarity).:
    • Q13098
  • The N-terminal part (1-216), which is not required for deneddylating activity and CSN complex formation, is nevertheless essential for other aspects of CSN complex function, such as repression of c-fos/FOS expression.:
    • Q13098
  • Contains 1 PCI domain.:
    • Q13098
Family:
  • Belongs to the CSN1 family.:
    • Q13098
genes like me logo Genes that share domains with GPS1: view

No data available for Gene Families for GPS1 Gene

Function for GPS1 Gene

Molecular function for GPS1 Gene

UniProtKB/Swiss-Prot Function: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

Gene Ontology (GO) - Molecular Function for GPS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005095 GTPase inhibitor activity TAS 8943324
GO:0005515 protein binding IPI 18850735
genes like me logo Genes that share ontologies with GPS1: view
genes like me logo Genes that share phenotypes with GPS1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GPS1 Gene

Localization for GPS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPS1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPS1 Gene COMPARTMENTS Subcellular localization image for GPS1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GPS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0008180 COP9 signalosome IDA 18850735
genes like me logo Genes that share ontologies with GPS1: view

Pathways for GPS1 Gene

SuperPathways for GPS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity TAS 8943324
GO:0007049 cell cycle TAS 8943324
GO:0007254 JNK cascade TAS 8943324
GO:0010388 cullin deneddylation IDA 19141280
GO:0034260 negative regulation of GTPase activity TAS 8943324
genes like me logo Genes that share ontologies with GPS1: view

No data available for Pathways by source for GPS1 Gene

Transcripts for GPS1 Gene

Unigene Clusters for GPS1 Gene

G protein pathway suppressor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPS1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ·
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - -
SP7:
SP8:
SP9: - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - -
SP13: - - - - - - - - - - - -
SP14: - - - - - -
SP15: - - - - - - -
SP16: - - - - - -
SP17: - - - - - - -
SP18: - - - - -
SP19: - - - - - -
SP20: - -
SP21: - - - - - - - -
SP22: - - - - -
SP23:
SP24:
SP25: - -
SP26:
SP27: - - - - - - -
SP28:

ExUns: 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b · 17c
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23: -
SP24: -
SP25:
SP26:
SP27:
SP28: - -

Relevant External Links for GPS1 Gene

GeneLoc Exon Structure for
GPS1
ECgene alternative splicing isoforms for
GPS1

Expression for GPS1 Gene

mRNA expression in normal human tissues for GPS1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for GPS1 Gene

SOURCE GeneReport for Unigene cluster for GPS1 Gene Hs.268530

mRNA Expression by UniProt/SwissProt for GPS1 Gene

Q13098-CSN1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with GPS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GPS1 Gene

Orthologs for GPS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPS1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPS1 35
  • 89.73 (n)
  • 97.06 (a)
GPS1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPS1 35
  • 90.28 (n)
  • 97.92 (a)
GPS1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gps1 35
  • 86.63 (n)
  • 95.82 (a)
Gps1 16
Gps1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPS1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPS1 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gps1 35
  • 87.07 (n)
  • 95.63 (a)
chicken
(Gallus gallus)
Aves GPS1 35
  • 80.92 (n)
  • 95.81 (a)
GPS1 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPS1 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15278 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gps1 35
  • 77.01 (n)
  • 92.45 (a)
Str.10225 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12745 35
zebrafish
(Danio rerio)
Actinopterygii Dr.764 35
gps1 35
  • 78.87 (n)
  • 92.68 (a)
gps1 36
  • 90 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004953 35
  • 68.64 (n)
  • 70.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CSN1b 35
  • 66.52 (n)
  • 67.1 (a)
CSN1b 36
  • 58 (a)
OneToOne
CSN1b 37
  • 60 (a)
BG:DS06874.2 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea csn-1 36
  • 20 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN7 36
  • 20 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.2471 35
thale cress
(Arabidopsis thaliana)
eudicotyledons FUS6 35
  • 52.81 (n)
  • 48.66 (a)
rice
(Oryza sativa)
Liliopsida Os03g0116500 35
  • 52.78 (n)
  • 47.22 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8905 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6603 36
  • 60 (a)
OneToOne
Species with no ortholog for GPS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPS1 Gene

ENSEMBL:
Gene Tree for GPS1 (if available)
TreeFam:
Gene Tree for GPS1 (if available)

Paralogs for GPS1 Gene

Paralogs for GPS1 Gene

Pseudogenes.org Pseudogenes for GPS1 Gene

genes like me logo Genes that share paralogs with GPS1: view

Variants for GPS1 Gene

Sequence variations from dbSNP and Humsavar for GPS1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs10013 -- 82,057,352(+) GTCCC(C/G)AGGGA utr-variant-3-prime
rs12841 -- 82,057,209(-) CCGCA(C/G)GCAGC utr-variant-3-prime
rs4969464 -- 82,055,359(+) CATGT(A/G)CAGGT intron-variant
rs4969484 -- 82,056,985(+) CTGGC(G/T)TGAGG intron-variant, missense, reference
rs11077966 -- 82,054,573(+) GACAC(A/G)GCCTG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for GPS1 Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
dgv3333n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
dgv3339n71 CNV Loss 21882294
nsv909151 CNV Gain+Loss 21882294
dgv3340n71 CNV Loss 21882294
dgv3341n71 CNV Loss 21882294
dgv3343n71 CNV Loss 21882294
nsv909166 CNV Loss 21882294
nsv457975 CNV Loss 19166990
nsv909167 CNV Gain+Loss 21882294
dgv3344n71 CNV Loss 21882294
dgv3345n71 CNV Loss 21882294
dgv3347n71 CNV Loss 21882294
nsv909181 CNV Loss 21882294
dgv3349n71 CNV Loss 21882294
nsv457976 CNV Gain 19166990
nsv470621 CNV Gain 18288195
nsv909186 CNV Loss 21882294
dgv3350n71 CNV Loss 21882294
nsv909188 CNV Loss 21882294
dgv3351n71 CNV Loss 21882294
dgv3352n71 CNV Loss 21882294
nsv909192 CNV Gain 21882294
dgv3353n71 CNV Loss 21882294

Relevant External Links for GPS1 Gene

HapMap Linkage Disequilibrium report
GPS1
Human Gene Mutation Database (HGMD)
GPS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPS1 Gene

Disorders for GPS1 Gene

No disorders were found for GPS1 Gene.

No data available for UniProtKB/Swiss-Prot for GPS1 Gene

Publications for GPS1 Gene

  1. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PMID: 9535219) Seeger M. … Dubiel W. (FASEB J. 1998) 2 3 4
  2. Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1. (PMID: 12324474) Sun Y. … Majerus P.W. (J. Biol. Chem. 2002) 3 4
  3. Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. (PMID: 12628923) Uhle S. … Dubiel W. (EMBO J. 2003) 3 4
  4. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (PMID: 12732143) Groisman R. … Nakatani Y. (Cell 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for GPS1 Gene

Sources for GPS1 Gene

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