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Aliases for GPS1 Gene

Aliases for GPS1 Gene

  • G Protein Pathway Suppressor 1 2 3 4 5
  • JAB1-Containing Signalosome Subunit 1 3 4
  • COPS1 3 4
  • SGN1 3 4
  • CSN1 3 4
  • COP9 Signalosome Complex Subunit 1 3
  • COP9 Signalosome Subunit 1 2
  • Signalosome Subunit 1 4
  • Protein MFH 4
  • GPS-1 4

External Ids for GPS1 Gene

Previous GeneCards Identifiers for GPS1 Gene

  • GC17P079433
  • GC17P9J0051
  • GC17P080545
  • GC17P077603
  • GC17P080009
  • GC17P075409

Summaries for GPS1 Gene

Entrez Gene Summary for GPS1 Gene

  • This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. [provided by RefSeq, Mar 2016]

GeneCards Summary for GPS1 Gene

GPS1 (G Protein Pathway Suppressor 1) is a Protein Coding gene. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and Clathrin-mediated endocytosis. GO annotations related to this gene include GTPase inhibitor activity. An important paralog of this gene is PSMD6.

UniProtKB/Swiss-Prot for GPS1 Gene

  • Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

Gene Wiki entry for GPS1 Gene

Additional gene information for GPS1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPS1 Gene

Genomics for GPS1 Gene

Regulatory Elements for GPS1 Gene

Enhancers for GPS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H082492 2.1 FANTOM5 Ensembl ENCODE dbSUPER 41.4 +444.8 444802 6 ZFP64 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC ZFP41 MEF2D TBCD HGS NARF ALYREF ENSG00000260563 GPS1 ARL2BPP9 FOXK2 NARF-IT1 ENSG00000262652
GH17H082281 1.8 FANTOM5 Ensembl ENCODE dbSUPER 28.9 +232.1 232097 2 HDGF ARNT ZNF493 YBX1 GLI4 ZNF48 ZBTB7B GLIS2 ELK1 ZNF207 TBCD FAAP100 OGFOD3 ENSG00000260563 ENSG00000262877 NARF-IT1 ENSG00000262652 ENSG00000265678 ARL2BPP9 GPS1
GH17H081384 2.1 FANTOM5 Ensembl ENCODE dbSUPER 20.6 -654.6 -654588 22 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 SP3 NFYC MEF2D ZNF610 ENSG00000262877 CEP131 ARL16 GPS1 HGS ENDOV ALYREF CCDC57 TSPAN10 TMEM105
GH17H082671 1.1 ENCODE dbSUPER 28.8 +620.5 620469 0 ARNT ZNF473 ZNF493 ZSCAN4 NFRKB ZNF195 YBX1 PLRG1 ZNF207 KLF7 TBCD WDR45B OGFOD3 GPS1 HEXDC ENSG00000260563 ENSG00000263321 ENSG00000262652 ARL2BPP9 NARF-IT1
GH17H082715 1 ENCODE 25 +666.4 666358 2 HDGF ATF1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B FN3KRP TBCD LOC101929552 GPS1 FOXK2 ENSG00000263321 CCDC57 ENSG00000265678 OGFOD3 ENSG00000264548
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPS1 on UCSC Golden Path with GeneCards custom track

Promoters for GPS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000099527 1209 1801 TBL1XR1 RB1 ARID4B SIN3A DMAP1 ZBTB40 ETS1 GLIS2 ELK1 CREM

Genomic Location for GPS1 Gene

Chromosome:
17
Start:
82,050,691 bp from pter
End:
82,057,470 bp from pter
Size:
6,780 bases
Orientation:
Plus strand

Genomic View for GPS1 Gene

Genes around GPS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPS1 Gene

Proteins for GPS1 Gene

  • Protein details for GPS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13098-CSN1_HUMAN
    Recommended name:
    COP9 signalosome complex subunit 1
    Protein Accession:
    Q13098
    Secondary Accessions:
    • Q8NA10
    • Q9BWL1

    Protein attributes for GPS1 Gene

    Size:
    491 amino acids
    Molecular mass:
    55537 Da
    Quaternary structure:
    • Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:11337588, PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS2, COPS3, COPS4 and COPS5 (PubMed:11114242). Interacts directly with inositol kinase ITPK1 (PubMed:12324474). Interacts with CAPN8 (By similarity).
    SequenceCaution:
    • Sequence=AAC50906.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GPS1 Gene

    Alternative splice isoforms for GPS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPS1 Gene

Post-translational modifications for GPS1 Gene

  • Ubiquitination at isoforms=7, 6, 5183, posLast=224224, posLast=248248, posLast=268268, isoforms=7, 6, 5422, posLast=438438, isoforms=7, 6, 5444, and isoforms=7, 5467
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPS1 Gene

Domains & Families for GPS1 Gene

Gene Families for GPS1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GPS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13098

UniProtKB/Swiss-Prot:

CSN1_HUMAN :
  • The PCI domain is necessary and sufficient for the interactions with other CSN subunits of the complex. Mediates the interaction with CAPN8 (By similarity).
  • Belongs to the CSN1 family.
Domain:
  • The PCI domain is necessary and sufficient for the interactions with other CSN subunits of the complex. Mediates the interaction with CAPN8 (By similarity).
  • The N-terminal part (1-216), which is not required for deneddylating activity and CSN complex formation, is nevertheless essential for other aspects of CSN complex function, such as repression of c-fos/FOS expression.
Family:
  • Belongs to the CSN1 family.
genes like me logo Genes that share domains with GPS1: view

Function for GPS1 Gene

Molecular function for GPS1 Gene

UniProtKB/Swiss-Prot Function:
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

Phenotypes From GWAS Catalog for GPS1 Gene

Gene Ontology (GO) - Molecular Function for GPS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005095 GTPase inhibitor activity TAS 8943324
GO:0005515 protein binding IPI 15304329
genes like me logo Genes that share ontologies with GPS1: view
genes like me logo Genes that share phenotypes with GPS1: view

Animal Models for GPS1 Gene

MGI Knock Outs for GPS1:
  • Gps1 tm1b(KOMP)Wtsi

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPS1 Gene

Localization for GPS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPS1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPS1 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GPS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0008180 COP9 signalosome IEA,IDA 18850735
genes like me logo Genes that share ontologies with GPS1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPS1 Gene

Pathways & Interactions for GPS1 Gene

genes like me logo Genes that share pathways with GPS1: view

Gene Ontology (GO) - Biological Process for GPS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity TAS 8943324
GO:0000338 protein deneddylation IDA,IEA 19141280
GO:0000715 nucleotide-excision repair, DNA damage recognition TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0007049 cell cycle TAS 8943324
genes like me logo Genes that share ontologies with GPS1: view

No data available for SIGNOR curated interactions for GPS1 Gene

Drugs & Compounds for GPS1 Gene

No Compound Related Data Available

Transcripts for GPS1 Gene

Unigene Clusters for GPS1 Gene

G protein pathway suppressor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPS1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ·
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - -
SP7:
SP8:
SP9: - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - -
SP13: - - - - - - - - - - - -
SP14: - - - - - -
SP15: - - - - - - -
SP16: - - - - - -
SP17: - - - - - - -
SP18: - - - - -
SP19: - - - - - -
SP20: - -
SP21: - - - - - - - -
SP22: - - - - -
SP23:
SP24:
SP25: - -
SP26:
SP27: - - - - - - -
SP28:

ExUns: 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b · 17c
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23: -
SP24: -
SP25:
SP26:
SP27:
SP28: - -

Relevant External Links for GPS1 Gene

GeneLoc Exon Structure for
GPS1
ECgene alternative splicing isoforms for
GPS1

Expression for GPS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPS1 Gene

Protein differential expression in normal tissues from HIPED for GPS1 Gene

This gene is overexpressed in Lymph node (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPS1 Gene



Protein tissue co-expression partners for GPS1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPS1 Gene:

GPS1

SOURCE GeneReport for Unigene cluster for GPS1 Gene:

Hs.268530

mRNA Expression by UniProt/SwissProt for GPS1 Gene:

Q13098-CSN1_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for GPS1 Gene

  • Nervous system(4.8)
  • Intestine(3.6)
  • Lung(3.2)
  • Kidney(2.6)
  • Eye(2.5)
  • Skin(2.5)
  • Blood(2.4)
  • Liver(2.4)
  • Muscle(2.4)
  • Lymph node(2.2)
genes like me logo Genes that share expression patterns with GPS1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPS1 Gene

Orthologs for GPS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPS1 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPS1 34
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPS1 33 34
  • 90.28 (n)
cow
(Bos Taurus)
Mammalia GPS1 33 34
  • 89.73 (n)
rat
(Rattus norvegicus)
Mammalia Gps1 33
  • 87.07 (n)
mouse
(Mus musculus)
Mammalia Gps1 33 16 34
  • 86.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GPS1 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPS1 34 33
  • 80.92 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPS1 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gps1 33
  • 77.01 (n)
Str.10225 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15278 33
zebrafish
(Danio rerio)
Actinopterygii gps1 33 34
  • 78.87 (n)
Dr.764 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12745 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004953 33
  • 68.64 (n)
fruit fly
(Drosophila melanogaster)
Insecta CSN1b 33 34 35
  • 66.52 (n)
BG:DS06874.2 35
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea csn-1 34
  • 20 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN7 34
  • 20 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons FUS6 33
  • 52.81 (n)
soybean
(Glycine max)
eudicotyledons Gma.2471 33
rice
(Oryza sativa)
Liliopsida Os03g0116500 33
  • 52.78 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6603 34
  • 60 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8905 33
Species where no ortholog for GPS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPS1 Gene

ENSEMBL:
Gene Tree for GPS1 (if available)
TreeFam:
Gene Tree for GPS1 (if available)

Paralogs for GPS1 Gene

Paralogs for GPS1 Gene

Pseudogenes.org Pseudogenes for GPS1 Gene

genes like me logo Genes that share paralogs with GPS1: view

Variants for GPS1 Gene

Sequence variations from dbSNP and Humsavar for GPS1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000349452 -- 82,052,652(+) AGGAG(C/T)GCGGG intron-variant, upstream-variant-2KB
rs1000364181 -- 82,052,246(+) TCTTT(C/T)TCCCT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000457989 -- 82,055,675(+) TTAGC(A/G)GCTTC intron-variant
rs10013 -- 82,057,352(+) GTCCC(C/G)AGGGA utr-variant-3-prime
rs1001889356 -- 82,051,306(+) GAGCT(C/G)GAGCT upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GPS1 Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
nsv1112723 CNV deletion 24896259
nsv428351 CNV gain 18775914
nsv457975 CNV loss 19166990
nsv457976 CNV gain 19166990
nsv470620 CNV loss 18288195
nsv470621 CNV gain 18288195
nsv576183 CNV loss 21841781
nsv576187 CNV gain 21841781
nsv576188 CNV loss 21841781
nsv576189 CNV loss 21841781
nsv952392 CNV deletion 24416366

Variation tolerance for GPS1 Gene

Residual Variation Intolerance Score: 17.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPS1 Gene

Human Gene Mutation Database (HGMD)
GPS1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPS1 Gene

Disorders for GPS1 Gene

Relevant External Links for GPS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPS1

No disorders were found for GPS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPS1 Gene

Publications for GPS1 Gene

  1. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PMID: 9535219) Seeger M … Dubiel W (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998) 2 3 4 60
  2. CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome. (PMID: 26456823) Rozen S … Sharon M (Cell reports 2015) 3 4 60
  3. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PMID: 18850735) Fang L … Huang L (Journal of proteome research 2008) 3 4 60
  4. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) interacts with GPS1 (CSN1) and inhibits c-Jun NH2-terminal kinase activity. (PMID: 17276034) Li JY … Mulholland MW (Cellular signalling 2007) 3 22 60
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 60

Products for GPS1 Gene

Sources for GPS1 Gene

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