Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPS1 Gene

Aliases for GPS1 Gene

  • G Protein Pathway Suppressor 1 2 3 4 5
  • JAB1-Containing Signalosome Subunit 1 3 4
  • COPS1 3 4
  • SGN1 3 4
  • CSN1 3 4
  • COP9 Signalosome Complex Subunit 1 3
  • COP9 Signalosome Subunit 1 2
  • Signalosome Subunit 1 4
  • Protein MFH 4
  • GPS-1 4

External Ids for GPS1 Gene

Previous GeneCards Identifiers for GPS1 Gene

  • GC17P079433
  • GC17P9J0051
  • GC17P080545
  • GC17P077603
  • GC17P080009
  • GC17P075409

Summaries for GPS1 Gene

Entrez Gene Summary for GPS1 Gene

  • This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. [provided by RefSeq, Mar 2016]

GeneCards Summary for GPS1 Gene

GPS1 (G Protein Pathway Suppressor 1) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Transcription-Coupled Nucleotide Excision Repair (TC-NER). GO annotations related to this gene include GTPase inhibitor activity. An important paralog of this gene is PSMD6.

UniProtKB/Swiss-Prot for GPS1 Gene

  • Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

Gene Wiki entry for GPS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPS1 Gene

Genomics for GPS1 Gene

Regulatory Elements for GPS1 Gene

Enhancers for GPS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F082492 1.9 FANTOM5 Ensembl ENCODE 15.2 +445.3 445314 7.0 CREB3L1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 SP3 NARF ARL2BPP9 ALYREF ENSG00000262049 OGFOD3 ENSG00000262652 HGS LOC105371942 NARF-IT1 SECTM1
GH17F081089 1.7 FANTOM5 Ensembl ENCODE 12 -956.4 -956382 8.8 HDGF PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF766 ENSG00000262049 LOC100294362 ARL16 HGS EIF4A3 CEP131 ALYREF TEPSIN GPS1 SLC38A10
GH17F082870 1.7 FANTOM5 Ensembl ENCODE 12 +824.5 824544 9.5 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 FOS FN3KRP RAB40B GPS1 ENSG00000265678 LOC101929552 RFNG ZNF750 TBCD C17orf62 HEXDC
GH17F081990 1.6 FANTOM5 Ensembl ENCODE 12.2 -58.8 -58845 2.9 MLX ZFP64 ARID4B DMAP1 ZNF48 BRCA1 ZNF121 SLC30A9 PAF1 SP5 ENSG00000262049 ASPSCR1 GPS1 CEP131 ENSG00000265678 ARL16 RFNG ENSG00000262877 SLC25A10 DCXR
GH17F081048 1.6 FANTOM5 Ensembl ENCODE 12 -999.7 -999665 5.3 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 FOS ZNF263 LOC100294362 ENSG00000262049 CEP131 GPS1 ARL16 ENSG00000262877 BAIAP2 LOC105371924 SLC38A10 GC17M081121
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPS1 on UCSC Golden Path with GeneCards custom track

Promoters for GPS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001355528 1209 2601 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 ZNF263 SP3 SP5

Genomic Location for GPS1 Gene

Chromosome:
17
Start:
82,050,691 bp from pter
End:
82,057,470 bp from pter
Size:
6,780 bases
Orientation:
Plus strand

Genomic View for GPS1 Gene

Genes around GPS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPS1 Gene

Proteins for GPS1 Gene

  • Protein details for GPS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13098-CSN1_HUMAN
    Recommended name:
    COP9 signalosome complex subunit 1
    Protein Accession:
    Q13098
    Secondary Accessions:
    • Q8NA10
    • Q9BWL1

    Protein attributes for GPS1 Gene

    Size:
    491 amino acids
    Molecular mass:
    55537 Da
    Quaternary structure:
    • Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:11337588, PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS2, COPS3, COPS4 and COPS5 (PubMed:11114242). Interacts directly with inositol kinase ITPK1 (PubMed:12324474). Interacts with CAPN8 (By similarity).
    SequenceCaution:
    • Sequence=AAC50906.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GPS1 Gene

    Alternative splice isoforms for GPS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPS1 Gene

Post-translational modifications for GPS1 Gene

  • Ubiquitination at Lys 183, Lys 224, Lys 248, Lys 268, Lys 422, Lys 438, Lys 444, and Lys 467
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPS1 Gene

Domains & Families for GPS1 Gene

Gene Families for GPS1 Gene

Suggested Antigen Peptide Sequences for GPS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13098

UniProtKB/Swiss-Prot:

CSN1_HUMAN :
  • The PCI domain is necessary and sufficient for the interactions with other CSN subunits of the complex. Mediates the interaction with CAPN8 (By similarity).
  • Belongs to the CSN1 family.
Domain:
  • The PCI domain is necessary and sufficient for the interactions with other CSN subunits of the complex. Mediates the interaction with CAPN8 (By similarity).
  • The N-terminal part (1-216), which is not required for deneddylating activity and CSN complex formation, is nevertheless essential for other aspects of CSN complex function, such as repression of c-fos/FOS expression.
  • Contains 1 PCI domain.
Family:
  • Belongs to the CSN1 family.
genes like me logo Genes that share domains with GPS1: view

Function for GPS1 Gene

Molecular function for GPS1 Gene

UniProtKB/Swiss-Prot Function:
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

Gene Ontology (GO) - Molecular Function for GPS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005095 GTPase inhibitor activity TAS 8943324
GO:0005515 protein binding IPI 18850735
genes like me logo Genes that share ontologies with GPS1: view
genes like me logo Genes that share phenotypes with GPS1: view

Animal Models for GPS1 Gene

MGI Knock Outs for GPS1:
  • Gps1 tm1b(KOMP)Wtsi

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPS1 Gene

Localization for GPS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPS1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPS1 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GPS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0008180 COP9 signalosome IEA,IDA 18850735
genes like me logo Genes that share ontologies with GPS1: view

Pathways & Interactions for GPS1 Gene

genes like me logo Genes that share pathways with GPS1: view

Gene Ontology (GO) - Biological Process for GPS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity TAS 8943324
GO:0000715 nucleotide-excision repair, DNA damage recognition TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0007049 cell cycle TAS 8943324
GO:0007254 JNK cascade TAS 8943324
genes like me logo Genes that share ontologies with GPS1: view

No data available for SIGNOR curated interactions for GPS1 Gene

Transcripts for GPS1 Gene

Unigene Clusters for GPS1 Gene

G protein pathway suppressor 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPS1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ·
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - -
SP7:
SP8:
SP9: - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - -
SP13: - - - - - - - - - - - -
SP14: - - - - - -
SP15: - - - - - - -
SP16: - - - - - -
SP17: - - - - - - -
SP18: - - - - -
SP19: - - - - - -
SP20: - -
SP21: - - - - - - - -
SP22: - - - - -
SP23:
SP24:
SP25: - -
SP26:
SP27: - - - - - - -
SP28:

ExUns: 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b · 17c
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23: -
SP24: -
SP25:
SP26:
SP27:
SP28: - -

Relevant External Links for GPS1 Gene

GeneLoc Exon Structure for
GPS1
ECgene alternative splicing isoforms for
GPS1

Expression for GPS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPS1 Gene

Protein differential expression in normal tissues from HIPED for GPS1 Gene

This gene is overexpressed in Lymph node (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPS1 Gene



Protein tissue co-expression partners for GPS1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPS1 Gene:

GPS1

SOURCE GeneReport for Unigene cluster for GPS1 Gene:

Hs.268530

mRNA Expression by UniProt/SwissProt for GPS1 Gene:

Q13098-CSN1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with GPS1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GPS1 Gene

Orthologs for GPS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPS1 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPS1 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPS1 34 35
  • 90.28 (n)
cow
(Bos Taurus)
Mammalia GPS1 34 35
  • 89.73 (n)
rat
(Rattus norvegicus)
Mammalia Gps1 34
  • 87.07 (n)
mouse
(Mus musculus)
Mammalia Gps1 34 16 35
  • 86.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GPS1 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPS1 34 35
  • 80.92 (n)
lizard
(Anolis carolinensis)
Reptilia GPS1 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gps1 34
  • 77.01 (n)
Str.10225 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15278 34
zebrafish
(Danio rerio)
Actinopterygii gps1 34 35
  • 78.87 (n)
Dr.764 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12745 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004953 34
  • 68.64 (n)
fruit fly
(Drosophila melanogaster)
Insecta CSN1b 36 34 35
  • 66.52 (n)
BG:DS06874.2 36
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea csn-1 35
  • 20 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN7 35
  • 20 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons FUS6 34
  • 52.81 (n)
soybean
(Glycine max)
eudicotyledons Gma.2471 34
rice
(Oryza sativa)
Liliopsida Os03g0116500 34
  • 52.78 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6603 35
  • 60 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8905 34
Species where no ortholog for GPS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPS1 Gene

ENSEMBL:
Gene Tree for GPS1 (if available)
TreeFam:
Gene Tree for GPS1 (if available)

Paralogs for GPS1 Gene

Paralogs for GPS1 Gene

Pseudogenes.org Pseudogenes for GPS1 Gene

genes like me logo Genes that share paralogs with GPS1: view

Variants for GPS1 Gene

Sequence variations from dbSNP and Humsavar for GPS1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10013 -- 82,057,352(+) GTCCC(C/G)AGGGA utr-variant-3-prime
rs11077966 -- 82,054,573(+) GACAC(A/G)GCCTG reference, synonymous-codon
rs111290822 -- 82,053,551(+) AGCTT(C/T)AGATG intron-variant, upstream-variant-2KB
rs111309938 -- 82,057,217(+) CGGCC(C/T)AGCTA utr-variant-3-prime
rs111627972 -- 82,051,966(+) GCAGG(G/T)AACGA intron-variant, upstream-variant-2KB, splice-donor-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GPS1 Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
nsv1112723 CNV deletion 24896259
nsv428351 CNV gain 18775914
nsv457975 CNV loss 19166990
nsv457976 CNV gain 19166990
nsv470620 CNV loss 18288195
nsv470621 CNV gain 18288195
nsv576183 CNV loss 21841781
nsv576187 CNV gain 21841781
nsv576188 CNV loss 21841781
nsv576189 CNV loss 21841781
nsv952392 CNV deletion 24416366

Variation tolerance for GPS1 Gene

Residual Variation Intolerance Score: 17.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPS1 Gene

Human Gene Mutation Database (HGMD)
GPS1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPS1 Gene

Disorders for GPS1 Gene

Relevant External Links for GPS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPS1

No disorders were found for GPS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPS1 Gene

Publications for GPS1 Gene

  1. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PMID: 9535219) Seeger M. … Dubiel W. (FASEB J. 1998) 2 3 4 64
  2. CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome. (PMID: 26456823) Rozen S. … Sharon M. (Cell Rep 2015) 3 4 64
  3. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PMID: 18850735) Fang L. … Huang L. (J. Proteome Res. 2008) 3 4 64
  4. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) interacts with GPS1 (CSN1) and inhibits c-Jun NH2-terminal kinase activity. (PMID: 17276034) Li J.Y. … Mulholland M.W. (Cell. Signal. 2007) 3 22 64
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64

Products for GPS1 Gene

Sources for GPS1 Gene

Content
Loading form....