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Aliases for GPRIN2 Gene

Aliases for GPRIN2 Gene

  • G Protein Regulated Inducer Of Neurite Outgrowth 2 2 3 5
  • KIAA0514 2 3 4
  • GRIN2 3 4
  • G Protein-Regulated Inducer Of Neurite Outgrowth 2 3

External Ids for GPRIN2 Gene

Previous HGNC Symbols for GPRIN2 Gene

  • KIAA0514

Previous GeneCards Identifiers for GPRIN2 Gene

  • GC10P046414
  • GC10P046993
  • GC10M046548

Summaries for GPRIN2 Gene

GeneCards Summary for GPRIN2 Gene

GPRIN2 (G Protein Regulated Inducer Of Neurite Outgrowth 2) is a Protein Coding gene. An important paralog of this gene is GPRIN1.

UniProtKB/Swiss-Prot for GPRIN2 Gene

  • May be involved in neurite outgrowth.

Gene Wiki entry for GPRIN2 Gene

Additional gene information for GPRIN2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPRIN2 Gene

Genomics for GPRIN2 Gene

Regulatory Elements for GPRIN2 Gene

Enhancers for GPRIN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H046538 1.3 FANTOM5 Ensembl ENCODE 7.4 +16.4 16355 3.2 CTCF ZNF146 KLF1 CHD4 SIN3A DMAP1 CHD7 YY1 TEAD3 CCNT2 SYT15 WASHC2C PARGP1 FAM21FP GPRIN2 ANXA8L1 PIR31182 GC10P046518
GH10H046516 0.8 Ensembl ENCODE 7.8 +39.9 39948 1.3 JUND ZNF157 SIN3A FOS RAD21 ZFX MAFK GPRIN2 GC10P046518 PIR56474
GH10H046468 1.1 FANTOM5 ENCODE 3.2 +88.4 88412 1.2 BCOR CTCF RB1 CHD4 ZMYM3 SIN3A RAD21 CC2D1A SMC3 PRDM10 LINC00842 GPRIN2 PIR43306 NPY4R
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPRIN2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for GPRIN2 Gene

Genomic Locations for GPRIN2 Gene
12,985 bases
Minus strand

Genomic View for GPRIN2 Gene

Genes around GPRIN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPRIN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPRIN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPRIN2 Gene

Proteins for GPRIN2 Gene

  • Protein details for GPRIN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G protein-regulated inducer of neurite outgrowth 2
    Protein Accession:
    Secondary Accessions:
    • Q5SVF0

    Protein attributes for GPRIN2 Gene

    458 amino acids
    Molecular mass:
    47450 Da
    Quaternary structure:
    • Interacts with activated forms of GNAO1 and GNAZ.
    • Sequence=BAA25440.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPRIN2 Gene

Post-translational modifications for GPRIN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GPRIN2 Gene

Domains & Families for GPRIN2 Gene

Gene Families for GPRIN2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GPRIN2 Gene


Suggested Antigen Peptide Sequences for GPRIN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GPRIN2: view

No data available for UniProtKB/Swiss-Prot for GPRIN2 Gene

Function for GPRIN2 Gene

Molecular function for GPRIN2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in neurite outgrowth.

Gene Ontology (GO) - Molecular Function for GPRIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15778465
genes like me logo Genes that share ontologies with GPRIN2: view
genes like me logo Genes that share phenotypes with GPRIN2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPRIN2 Gene

Localization for GPRIN2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPRIN2 gene
Compartment Confidence
nucleus 3
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GPRIN2 Gene

Pathways & Interactions for GPRIN2 Gene

SuperPathways for GPRIN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPRIN2 Gene


No data available for Pathways by source and SIGNOR curated interactions for GPRIN2 Gene

Drugs & Compounds for GPRIN2 Gene

No Compound Related Data Available

Transcripts for GPRIN2 Gene

mRNA/cDNA for GPRIN2 Gene

Unigene Clusters for GPRIN2 Gene

G protein regulated inducer of neurite outgrowth 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPRIN2 Gene

No ASD Table

Relevant External Links for GPRIN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPRIN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPRIN2 Gene

mRNA differential expression in normal tissues according to GTEx for GPRIN2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x6.8), Skin - Not Sun Exposed (Suprapubic) (x6.6), Lung (x5.0), Brain - Cerebellar Hemisphere (x4.7), and Brain - Cerebellum (x4.5).

Protein differential expression in normal tissues from HIPED for GPRIN2 Gene

This gene is overexpressed in Heart (66.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPRIN2 Gene

Protein tissue co-expression partners for GPRIN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPRIN2 Gene:


SOURCE GeneReport for Unigene cluster for GPRIN2 Gene:


mRNA Expression by UniProt/SwissProt for GPRIN2 Gene:

Tissue specificity: Expressed specifically in the cerebellum.
genes like me logo Genes that share expression patterns with GPRIN2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPRIN2 Gene

Orthologs for GPRIN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPRIN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPRIN2 33 34
  • 94.91 (n)
(Bos Taurus)
Mammalia GPRIN2 33 34
  • 83.22 (n)
(Mus musculus)
Mammalia Gprin2 33 16 34
  • 78.9 (n)
(Rattus norvegicus)
Mammalia Gprin2 33
  • 77.95 (n)
(Canis familiaris)
Mammalia GPRIN2 34
  • 67 (a)
(Monodelphis domestica)
Mammalia GPRIN2 34
  • 38 (a)
(Ornithorhynchus anatinus)
Mammalia GPRIN2 34
  • 33 (a)
(Gallus gallus)
Aves GPRIN2 34
  • 26 (a)
(Anolis carolinensis)
Reptilia GPRIN2 34
  • 27 (a)
(Danio rerio)
Actinopterygii si:ch211-149b19.2 34
  • 9 (a)
Dr.23013 33
Species where no ortholog for GPRIN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPRIN2 Gene

Gene Tree for GPRIN2 (if available)
Gene Tree for GPRIN2 (if available)

Paralogs for GPRIN2 Gene

Paralogs for GPRIN2 Gene

genes like me logo Genes that share paralogs with GPRIN2: view

Variants for GPRIN2 Gene

Sequence variations from dbSNP and Humsavar for GPRIN2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000155995 -- 46,555,124(+) TATTT(G/T)TAGTA intron-variant
rs1000565599 -- 46,544,846(+) AAACT(A/G)ATTTG intron-variant, utr-variant-3-prime
rs1000957539 -- 46,547,764(+) CCTGG(C/T)ACCAT intron-variant, utr-variant-3-prime
rs1000976129 -- 46,543,665(+) TCCCC(C/T)GCCCT intron-variant, downstream-variant-500B
rs1001052525 -- 46,547,903(+) ACTTT(C/G)TCCTT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GPRIN2 Gene

Variant ID Type Subtype PubMed ID
nsv438172 CNV loss 16468122
nsv482145 CNV gain 20164927
nsv550722 CNV gain 21841781
nsv550723 CNV gain 21841781
nsv820817 CNV duplication 20802225
nsv947929 CNV duplication 23825009
nsv951576 CNV duplication 24416366
nsv437670 CNV loss 16327808
nsv1152446 CNV duplication 26484159
nsv1075819 CNV duplication 25765185
nsv1050696 CNV gain 25217958
nsv1050225 CNV gain+loss 25217958
nsv1049394 CNV loss 25217958
nsv1047710 CNV gain+loss 25217958
nsv1044044 CNV gain+loss 25217958
nsv1041409 CNV loss 25217958
esv3891799 CNV gain 25118596
esv3584617 CNV loss 24956385
esv3578829 CNV loss 25503493
esv3576928 CNV gain 25503493
esv3440422 CNV duplication 20981092
esv3385822 CNV duplication 20981092
esv3330359 CNV duplication 20981092
esv2736152 CNV deletion 23290073
esv2632472 CNV gain 19546169
dgv8n68 CNV gain 17160897
dgv783n100 CNV gain 25217958
dgv782n100 CNV loss 25217958
dgv781n100 CNV loss 25217958
dgv780n100 CNV gain 25217958
dgv771n100 CNV loss 25217958
dgv768n100 CNV loss 25217958
dgv767n100 CNV gain 25217958
dgv765n100 CNV loss 25217958
dgv764n100 CNV loss 25217958
dgv763n100 CNV gain 25217958
dgv760n100 CNV gain 25217958
dgv759n100 CNV loss 25217958
dgv753n100 CNV gain 25217958
dgv752n100 CNV loss 25217958
dgv751n100 CNV gain 25217958
dgv750n100 CNV loss 25217958
dgv749n100 CNV gain+loss 25217958
dgv748n100 CNV gain 25217958
dgv747n100 CNV gain+loss 25217958
dgv743n100 CNV gain 25217958
dgv742n100 CNV loss 25217958
dgv740n100 CNV gain+loss 25217958
dgv739n100 CNV gain 25217958
dgv738n100 CNV loss 25217958
dgv737n100 CNV loss 25217958
dgv734n100 CNV gain 25217958
dgv440n106 CNV duplication 24896259
dgv412e59 CNV duplication 20981092
dgv409e59 CNV duplication 20981092
dgv22e55 CNV gain 17911159
dgv223e212 CNV loss 25503493
dgv219e212 CNV gain 25503493
dgv218e212 CNV loss 25503493
dgv216e212 CNV loss 25503493
dgv148n67 CNV gain 20364138
dgv147n67 CNV gain 20364138
dgv116e214 CNV gain 21293372

Variation tolerance for GPRIN2 Gene

Residual Variation Intolerance Score: 99.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.81; 97.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPRIN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPRIN2 Gene

Disorders for GPRIN2 Gene

Relevant External Links for GPRIN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPRIN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPRIN2 Gene

Publications for GPRIN2 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 60
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. A candidate target for G protein action in brain. (PMID: 10480904) Chen LT … Kozasa T (The Journal of biological chemistry 1999) 3 4 60
  5. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart AE … Wells CM (The Journal of cell biology 2015) 3 60

Products for GPRIN2 Gene

Sources for GPRIN2 Gene

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