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GPRIN1 Gene

protein-coding   GIFtS: 47
GCID: GC05M176022

G Protein Regulated Inducer Of Neurite Outgrowth 1

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disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section


Aliases
G Protein Regulated Inducer Of Neurite Outgrowth 11 2
GRIN12 3 5
KIAA18933 5
G Protein-Regulated Inducer Of Neurite Outgrowth 12

External Ids:    HGNC: 248351   Entrez Gene: 1147872   Ensembl: ENSG000001692587   OMIM: 6112395   UniProtKB: Q7Z2K83   

Export aliases for GPRIN1 gene to outside databases

Previous GC identifiers: GC05M175956 GC05M175957 GC05M170947


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section


GeneCards Summary for GPRIN1 Gene:
GPRIN1 (G protein regulated inducer of neurite outgrowth 1) is a protein-coding gene. GO annotations related to this gene include phosphoprotein binding. An important paralog of this gene is GPRIN3.

UniProtKB/Swiss-Prot: GRIN1_HUMAN, Q7Z2K8
Function: May be involved in neurite outgrowth (By similarity)

summary for GPRIN1 Gene:
NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and
AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B)
subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane
potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA
receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the
postsynaptic region where it activates several signaling cascades, including pathways leading to the
induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in
excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions
including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and
neuropathic pain syndromes.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPRIN1 gene promoter:
         SRF   Meis-1b   POU2F1   POU2F1a   POU2F1b   FOXO1a   POU2F1c   Meis-1a   FOXO1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPRIN1 promoter sequence
   Search Chromatin IP Primers for GPRIN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPRIN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35.2

GPRIN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPRIN1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M176022:  view genomic region     (about GC identifiers)

Start:
176,022,803 bp from pter      End:
176,037,134 bp from pter
Size:
14,332 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section


UniProtKB/Swiss-Prot: GRIN1_HUMAN, Q7Z2K8 (See protein sequence)
Recommended Name: G protein-regulated inducer of neurite outgrowth 1  
Size: 1008 amino acids; 102399 Da
Subunit: Interacts with activated forms of GNAI1, GNAO1 and GNAZ (By similarity)
Sequence caution: Sequence=BAB67786.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: C9JM70 Q8ND74 Q96PZ4
Alternative splicing: 2 isoforms:  Q7Z2K8-1   Q7Z2K8-2   

Explore the universe of human proteins at neXtProt for GPRIN1: NX_Q7Z2K8

Explore proteomics data for GPRIN1 at MOPED

Post-translational modifications: 

  • Palmitoylation on Cys-999 and/or Cys-1000 is required for membrane targeting (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GPRIN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_443131.2  
    ENSEMBL proteins: 
     ENSP00000305839  

    GPRIN1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GPRIN1
    GenScript Custom Purified and Recombinant Proteins Services for GPRIN1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GPRIN1

     
    Search eBioscience for Proteins for GPRIN1 

     
    Search antibodies-online for proteins for GPRIN1 

     
    Search antibodies-online for peptides for GPRIN1

     
    Search GeneTex for Proteins for GPRIN1 

    GPRIN1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals GPRIN1 Antibodies
    Abcam antibodies for GPRIN1
    Cloud-Clone Corp. Antibodies for GPRIN1
    Search ThermoFisher Antibodies for GPRIN1
    antibodies-online antibodies for GPRIN1 (22 products) 

     
    GeneTex Antibodies for GPRIN1:  
                        GPRIN1 Antibodies

    GPRIN1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GPRIN1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GPRIN1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GPRIN1
    Cloud-Clone Corp. CLIAs for GPRIN1
    Search eBioscience for ELISAs for GPRIN1 
    antibodies-online kits for GPRIN1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    1 InterPro protein domain:
     IPR026601 GPRIN1

    Graphical View of Domain Structure for InterPro Entry Q7Z2K8

    ProtoNet protein and cluster: Q7Z2K8


    Find genes that share domains with GPRIN1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section


    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRIN1_HUMAN, Q7Z2K8
    Function: May be involved in neurite outgrowth (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051219phosphoprotein binding IEA--
         
    Find genes that share ontologies with GPRIN1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GPRIN1:
     Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Gprin1 (no phenotypes)

    Find genes that share phenotypes with GPRIN1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Gprin1tm1Lex for GPRIN1

       genOway: Develop your customized and physiologically relevant rodent model for GPRIN1

        Taconic Biosciences Mouse Models for GPRIN1:  
                        TF0277 - Gprin1

    CRISPR Knockouts: 
       OriGene CRISPR knockouts for GPRIN1

    miRNA
    Products:
        
    miRTarBase miRNAs that target GPRIN1:
    hsa-mir-125b-5p (MIRT045959)

    Block miRNA regulation of human, mouse, rat GPRIN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GPRIN1 (see all 10):
    hsa-miR-596 hsa-miR-4324 hsa-miR-4271 hsa-miR-1266 hsa-miR-4251 hsa-miR-2110 hsa-miR-3150a-3p hsa-miR-513b
    SwitchGear 3'UTR luciferase reporter plasmidGPRIN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GPRIN1
    Predesigned siRNA for gene silencing in human, mouse, rat GPRIN1

    Clone
    Products:
         
    OriGene clones in human, mouse for GPRIN1 (see all 5)
    OriGene ORF clones in mouse, rat for GPRIN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GPRIN1 (NM_052899)
    Browse Sino Biological Human cDNA Clones
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPRIN1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GPRIN1
    Browse ESI BIO Cell Lines and PureStem Progenitors for GPRIN1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPRIN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section


    Subcellular locations from UniProtKB/Swiss-Prot
    GRIN1_HUMAN, Q7Z2K8: Cell membrane; Lipid-anchor (By similarity). Cell projection, growth cone (By similarity).
    Note=Highly enriched in growth cone (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus3
    cytosol2
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0030426growth cone IEA--

    Find genes that share ontologies with GPRIN1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section




    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GPRIN1 (see all 8)
        Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Pathogenesis of ALS
    Transcriptional Regulatory Network in Embryonic Stem Cell
    Intracellular Calcium Signaling
    Huntington's Disease Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GPRIN1
    Interactions:

        Search GeneGlobe Interaction Network for GPRIN1

    2 Interacting proteins for GPRIN1 (Q7Z2K83) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PXNP490233I2D: score=1 
    YWHABP319463I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031175neuron projection development IEA--

    Find genes that share ontologies with GPRIN1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GPRIN1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DL-AP5 Sodium saltSodium salt of DL-AP5 (Cat. No. 0105)[1303993-72-7]
    (+)-MK 801 maleate Non-competitive NMDA antagonist, acts at ion channel site [77086-22-7]
    D-AP5 Potent, selective NMDA antagonist. More active form of DL-AP5 (Cat. No. 0105) [79055-68-8]
    QNZ 46NR2C/NR2D-selective NMDA receptor non-competitive antagonist[1237744-13-6]
    DL-AP5 Potent, selective NMDA antagonist [76326-31-3]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section


    REFSEQ mRNAs for GPRIN1 gene (2 alternative transcripts): 
    NM_052899.2  XM_005265806.2  

    Unigene Cluster for GPRIN1:

    G protein regulated inducer of neurite outgrowth 1
    Hs.150549  [show with all ESTs]
    Unigene Representative Sequence: BC052950
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000303991(uc003meo.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GPRIN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GPRIN1 (see all 10):
    hsa-miR-596 hsa-miR-4324 hsa-miR-4271 hsa-miR-1266 hsa-miR-4251 hsa-miR-2110 hsa-miR-3150a-3p hsa-miR-513b
    SwitchGear 3'UTR luciferase reporter plasmidGPRIN1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GPRIN1
    Predesigned siRNA for gene silencing in human, mouse, rat GPRIN1
    Clone
    Products:
         
    OriGene clones in human, mouse for GPRIN1 (see all 5)
    OriGene ORF clones in mouse, rat for GPRIN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GPRIN1 (NM_052899)
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPRIN1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GPRIN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GPRIN1
      QuantiTect SYBR Green Assays in human, mouse, rat GPRIN1
      QuantiFast Probe-based Assays in human, mouse, rat GPRIN1

    Additional mRNA sequence: 

    AB067480.1 AL834165.1 BC052950.1 

    6 DOTS entries:

    DT.100660670  DT.97844356  DT.95293761  DT.120839723  DT.120839732  DT.92029607 

    Selected AceView cDNA sequences (see all 93):

    AA773544 BQ069517 CR609945 AW161048 BQ070533 AI824128 BF984077 BQ953107 
    BQ894607 BQ899174 BQ068316 BQ882632 AW162614 D60025 AI379236 BM804010 
    AW161877 BM927054 BQ888019 BX433031 BQ071418 BQ962162 AW161457 BQ070611 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPRIN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GPRIN1 Expression
    About this image


    GPRIN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Zeugopod Long Bone
     
     Cartilage (Muscoskeletal System)
             Meckel's Cartilage
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Midbrain tegmentum
    GPRIN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPRIN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.150549

    UniProtKB/Swiss-Prot: GRIN1_HUMAN, Q7Z2K8
    Tissue specificity: Widely expressed in the central nervous system, with highest levels in spinal cord

        Custom PCR Arrays for GPRIN1
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    QuantiFast Probe-based Assays in human, mouse, rat GPRIN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPRIN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section


    This gene was present in the common ancestor of chordates.

    Orthologs for GPRIN1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gprin11 , 5 G protein-regulated inducer of neurite outgrowth 11, 5 72.6(n)1
    62.31(a)1
      13 (29.18 cM)5
    269131  NM_012014.31  NP_036144.21 
     547366715 
    chicken
    (Gallus gallus)
    Aves GPRIN16
    G protein regulated inducer of neurite outgrowth 1...
    27(a)
    1 ↔ 1
    13(9685099-9687474)
    lizard
    (Anolis carolinensis)
    Reptilia GPRIN16
    G protein regulated inducer of neurite outgrowth 1...
    46(a)
    1 ↔ 1
    GL343548.1(84374-85096)
    zebrafish
    (Danio rerio)
    Actinopterygii GPRIN16
    G protein regulated inducer of neurite outgrowth 1...
    19(a)
    1 ↔ 1
    13(53360099-53361751) ENSDARG00000086973


    ENSEMBL Gene Tree for GPRIN1 (if available)
    TreeFam Gene Tree for GPRIN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for GPRIN1 gene
    GPRIN32  GPRIN22  

    Find genes that share paralogs with GPRIN1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section


    Selected SNPs for GPRIN1 (see all 362)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1434133191,2
    --176023309(+) CTCACG/TTGCTG 1 -- ut310--------
    rs1158700951,2
    C,F--176023326(+) ACCTCA/GCATTC 1 -- ut311Minor allele frequency- G:0.01WA 118
    rs68621871,2
    C,F,H--176023466(+) TAGACA/GTCTCA 1 -- ut31 ese35Minor allele frequency- G:0.03NS EA WA 536
    rs1121642391,2
    C,F--176023647(+) TCTGTA/CTTTGT 1 -- ut312Minor allele frequency- C:0.06CSA WA 120
    rs1442184051,2
    C--176023984(+) CTTGGC/GGGCCG 2 P R mis11Minor allele frequency- G:0.00NA 2620
    rs1477805121,2
    --176023997(+) CTCCTC/GGATCT 2 Q E mis10--------
    rs1397403611,2
    C,F--176024119(+) CAGCCG/AGCTCC 2 /P /L mis12Minor allele frequency- A:0.00NA EU 3721
    rs2005883871,2
    --176024166(+) CGCACC/GCGCAC 2 R syn10--------
    rs1913787161,2
    --176024478(+) GGCCCC/TGGCGG 2 P syn10--------
    rs2001599611,2
    --176024677(+) AGGACA/GGCTTG 2 P L mis10--------

    HapMap Linkage Disequilibrium report for GPRIN1 (176022803 - 176037134 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GPRIN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv471056CNV Loss18288195
    nsv883145CNV Loss21882294
    dgv6375n71CNV Loss21882294
    nsv883144CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPRIN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 611239    OMIM disorders: --


    Find genes that share disorders with GPRIN1           About GenesLikeMe


    Export disorders for GPRIN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section


    PubMed articles for GPRIN1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with GPRIN1)

    1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. A candidate target for G protein action in brain. (PubMed id 10480904)1, 2 Chen L.T.... Kozasa T. (J. Biol. Chem. 1999)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    6. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)
    7. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1 Beausoleil S.A.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    8. Identification and biochemical analysis of GRIN1 and GRIN2. (PubMed id 15488195)1 Iida N. and Kozasa T. (Meth. Enzymol. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 114787 HGNC: 24835 AceView: KIAA1893 Ensembl:ENSG00000169258 euGenes: HUgn114787
    ECgene: GPRIN1 H-InvDB: GPRIN1

    (According to HUGE)
    About This Section
    HUGE: KIAA1893

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GPRIN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GPRIN1 gene:
    Search GeneIP for patents involving GPRIN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Clones from OriGene, GenScript, Sino Biological, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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