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Aliases for GPRIN1 Gene

Aliases for GPRIN1 Gene

  • G Protein Regulated Inducer Of Neurite Outgrowth 1 2 3
  • GRIN1 3 4 6
  • KIAA1893 4 6
  • G Protein-Regulated Inducer Of Neurite Outgrowth 1 3

External Ids for GPRIN1 Gene

Previous GeneCards Identifiers for GPRIN1 Gene

  • GC05M175956
  • GC05M175957
  • GC05M176022
  • GC05M170947

Summaries for GPRIN1 Gene

GeneCards Summary for GPRIN1 Gene

GPRIN1 (G Protein Regulated Inducer Of Neurite Outgrowth 1) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Ras signaling pathway. GO annotations related to this gene include phosphoprotein binding. An important paralog of this gene is GPRIN3.

UniProtKB/Swiss-Prot for GPRIN1 Gene

  • May be involved in neurite outgrowth.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPRIN1 Gene

Genomics for GPRIN1 Gene

Regulatory Elements for GPRIN1 Gene

Genomic Location for GPRIN1 Gene

Start:
176,595,802 bp from pter
End:
176,617,357 bp from pter
Size:
21,556 bases
Orientation:
Minus strand

Genomic View for GPRIN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPRIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPRIN1 Gene

Proteins for GPRIN1 Gene

  • Protein details for GPRIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z2K8-GRIN1_HUMAN
    Recommended name:
    G protein-regulated inducer of neurite outgrowth 1
    Protein Accession:
    Q7Z2K8
    Secondary Accessions:
    • C9JM70
    • Q8ND74
    • Q96PZ4

    Protein attributes for GPRIN1 Gene

    Size:
    1008 amino acids
    Molecular mass:
    102399 Da
    Quaternary structure:
    • Interacts with activated forms of GNAI1, GNAO1 and GNAZ.
    SequenceCaution:
    • Sequence=BAB67786.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for GPRIN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPRIN1 Gene

Proteomics data for GPRIN1 Gene at MOPED

Post-translational modifications for GPRIN1 Gene

  • Palmitoylation on Cys-999 and/or Cys-1000 is required for membrane targeting.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPRIN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPRIN1 Gene

Domains for GPRIN1 Gene

Protein Domains for GPRIN1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for GPRIN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GPRIN1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GPRIN1 Gene

Function for GPRIN1 Gene

Molecular function for GPRIN1 Gene

UniProtKB/Swiss-Prot Function: May be involved in neurite outgrowth.

Gene Ontology (GO) - Molecular Function for GPRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051219 phosphoprotein binding IEA --
genes like me logo Genes that share ontologies with GPRIN1: view

Phenotypes for GPRIN1 Gene

GenomeRNAi human phenotypes for GPRIN1:
genes like me logo Genes that share phenotypes with GPRIN1: view

miRNA for GPRIN1 Gene

miRTarBase miRNAs that target GPRIN1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GPRIN1 Gene

Localization for GPRIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPRIN1 Gene

Cell membrane; Lipid-anchor. Cell projection, growth cone. Note=Highly enriched in growth cone. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPRIN1 Gene COMPARTMENTS Subcellular localization image for GPRIN1 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GPRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0030426 growth cone IEA --
GO:0042995 cell projection --
genes like me logo Genes that share ontologies with GPRIN1: view

Pathways for GPRIN1 Gene

genes like me logo Genes that share pathways with GPRIN1: view

Interacting Proteins for GPRIN1 Gene

Selected Interacting proteins: Q7Z2K8-GRIN1_HUMAN for GPRIN1 Gene via I2D

Symbol External ID(s) Details
PXN
YWHAB

Gene Ontology (GO) - Biological Process for GPRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031175 neuron projection development IEA --
genes like me logo Genes that share ontologies with GPRIN1: view

Transcripts for GPRIN1 Gene

mRNA/cDNA for GPRIN1 Gene

(93) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPRIN1 Gene

G protein regulated inducer of neurite outgrowth 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPRIN1 Gene

No ASD Table

Relevant External Links for GPRIN1 Gene

GeneLoc Exon Structure for
GPRIN1
ECgene alternative splicing isoforms for
GPRIN1

Expression for GPRIN1 Gene

mRNA expression in normal human tissues for GPRIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPRIN1 Gene

This gene is overexpressed in Brain - Cortex (5.8), Brain - Anterior cingulate cortex (BA24) (5.8), Brain - Cerebellar Hemisphere (5.7), Brain - Frontal Cortex (BA9) (5.7), Brain - Amygdala (5.1), Brain - Cerebellum (4.4), and Brain - Hypothalamus (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for GPRIN1 Gene

SOURCE GeneReport for Unigene cluster for GPRIN1 Gene Hs.150549

mRNA Expression by UniProt/SwissProt for GPRIN1 Gene

Q7Z2K8-GRIN1_HUMAN
Tissue specificity: Widely expressed in the central nervous system, with highest levels in spinal cord.
genes like me logo Genes that share expressions with GPRIN1: view

Orthologs for GPRIN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPRIN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPRIN1 36
  • 50 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPRIN1 35
  • 79.39 (n)
  • 69.58 (a)
GPRIN1 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPRIN1 35
  • 78.03 (n)
  • 65.21 (a)
GPRIN1 36
  • 41 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gprin1 35
  • 72.6 (n)
  • 62.31 (a)
Gprin1 16
Gprin1 36
  • 48 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPRIN1 36
  • 41 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gprin1 35
  • 73.03 (n)
  • 61.8 (a)
chicken
(Gallus gallus)
Aves GPRIN1 36
  • 27 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPRIN1 36
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii GPRIN1 36
  • 19 (a)
OneToOne
Species with no ortholog for GPRIN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPRIN1 Gene

ENSEMBL:
Gene Tree for GPRIN1 (if available)
TreeFam:
Gene Tree for GPRIN1 (if available)

Paralogs for GPRIN1 Gene

Paralogs for GPRIN1 Gene

genes like me logo Genes that share paralogs with GPRIN1: view

Variants for GPRIN1 Gene

Sequence variations from dbSNP and Humsavar for GPRIN1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs901743 -- 176,619,336(+) GCAGG(G/T)GCGGG upstream-variant-2KB
rs923323 -- 176,615,114(-) CGGGG(A/G)TAGTG intron-variant
rs1124715 -- 176,614,930(+) TAGAA(A/G)GTAAT intron-variant
rs1532032 -- 176,614,363(-) GTTGT(C/G)TTGGG intron-variant
rs1532033 -- 176,614,176(-) tgCGC(A/G)CGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPRIN1 Gene

Variant ID Type Subtype PubMed ID
nsv471056 CNV Loss 18288195
dgv6375n71 CNV Loss 21882294
nsv883144 CNV Loss 21882294
nsv883145 CNV Loss 21882294

Relevant External Links for GPRIN1 Gene

HapMap Linkage Disequilibrium report
GPRIN1
Human Gene Mutation Database (HGMD)
GPRIN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPRIN1 Gene

Disorders for GPRIN1 Gene

No disorders were found for GPRIN1 Gene.

No data available for UniProtKB/Swiss-Prot for GPRIN1 Gene

Publications for GPRIN1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A candidate target for G protein action in brain. (PMID: 10480904) Chen L.T. … Kozasa T. (J. Biol. Chem. 1999) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4

Products for GPRIN1 Gene

Sources for GPRIN1 Gene

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