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Aliases for GPRIN1 Gene

Aliases for GPRIN1 Gene

  • G Protein Regulated Inducer Of Neurite Outgrowth 1 2 3 5
  • GRIN1 3 4
  • G Protein-Regulated Inducer Of Neurite Outgrowth 1 3
  • KIAA1893 4

External Ids for GPRIN1 Gene

Previous GeneCards Identifiers for GPRIN1 Gene

  • GC05M175956
  • GC05M175957
  • GC05M176022
  • GC05M170947

Summaries for GPRIN1 Gene

GeneCards Summary for GPRIN1 Gene

GPRIN1 (G Protein Regulated Inducer Of Neurite Outgrowth 1) is a Protein Coding gene. Diseases associated with GPRIN1 include Psoriasis 14, Pustular. GO annotations related to this gene include phosphoprotein binding. An important paralog of this gene is GPRIN3.

UniProtKB/Swiss-Prot for GPRIN1 Gene

  • May be involved in neurite outgrowth.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPRIN1 Gene

Genomics for GPRIN1 Gene

Regulatory Elements for GPRIN1 Gene

Enhancers for GPRIN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F176580 0.6 ENCODE 11.6 +36.1 36105 1.6 CDHR2 RN7SL684P CLTB HIGD2A NOP16 GPRIN1 PIR54069 ENSG00000207420
GH05F176646 0.2 ENCODE 10.9 -30.6 -30590 3.0 HDGF ATF1 PKNOX1 SIN3A ZNF48 YY1 GLIS2 GATA2 ZNF143 KLF7 TSPAN17 GRK6 ENSG00000248996 GPRIN1 DOK3 HK3 ENSG00000248484
GH05F176423 0.2 ENCODE 10.5 +191.3 191299 5.6 ATF1 MLX ARID4B SIN3A ZNF48 YY1 MXD4 ZHX2 MIER2 PPARG FAF2 CDHR2 RN7SL684P MIR1271 ARL10 KIAA1191 GPRIN1 ENSG00000251414 HIGD2A CLTB
GH05F177308 0.6 ENCODE 4.5 -693.7 -693656 4.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF207 ZNF143 FOS MXD3 RGS14 RAB24 TSPAN17 GPRIN1 PIR37372
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GPRIN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPRIN1 Gene

176,595,802 bp from pter
176,617,338 bp from pter
21,537 bases
Minus strand

Genomic View for GPRIN1 Gene

Genes around GPRIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPRIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPRIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPRIN1 Gene

Proteins for GPRIN1 Gene

  • Protein details for GPRIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G protein-regulated inducer of neurite outgrowth 1
    Protein Accession:
    Secondary Accessions:
    • C9JM70
    • Q8ND74
    • Q96PZ4

    Protein attributes for GPRIN1 Gene

    1008 amino acids
    Molecular mass:
    102399 Da
    Quaternary structure:
    • Interacts with activated forms of GNAI1, GNAO1 and GNAZ.
    • Sequence=BAB67786.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for GPRIN1 Gene


neXtProt entry for GPRIN1 Gene

Post-translational modifications for GPRIN1 Gene

  • Palmitoylation on Cys-999 and/or Cys-1000 is required for membrane targeting.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPRIN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPRIN1 Gene

Domains & Families for GPRIN1 Gene

Protein Domains for GPRIN1 Gene


Suggested Antigen Peptide Sequences for GPRIN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GPRIN1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GPRIN1 Gene

Function for GPRIN1 Gene

Molecular function for GPRIN1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in neurite outgrowth.

Gene Ontology (GO) - Molecular Function for GPRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051219 phosphoprotein binding IEA --
genes like me logo Genes that share ontologies with GPRIN1: view
genes like me logo Genes that share phenotypes with GPRIN1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPRIN1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPRIN1 Gene

Localization for GPRIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPRIN1 Gene

Cell membrane; Lipid-anchor. Cell projection, growth cone. Note=Highly enriched in growth cone. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for GPRIN1 Gene COMPARTMENTS Subcellular localization image for GPRIN1 gene
Compartment Confidence
nucleus 4
plasma membrane 4
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GPRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0030426 growth cone IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with GPRIN1: view

Pathways & Interactions for GPRIN1 Gene

SuperPathways for GPRIN1 Gene

No Data Available

Interacting Proteins for GPRIN1 Gene

Selected Interacting proteins: Q7Z2K8-GRIN1_HUMAN for GPRIN1 Gene via IID

Gene Ontology (GO) - Biological Process for GPRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031175 neuron projection development IEA,IBA --
genes like me logo Genes that share ontologies with GPRIN1: view

No data available for Pathways by source and SIGNOR curated interactions for GPRIN1 Gene

Transcripts for GPRIN1 Gene

mRNA/cDNA for GPRIN1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(93) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPRIN1 Gene

G protein regulated inducer of neurite outgrowth 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPRIN1 Gene

No ASD Table

Relevant External Links for GPRIN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPRIN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPRIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPRIN1 Gene

This gene is overexpressed in Brain - Cortex (x5.8), Brain - Anterior cingulate cortex (BA24) (x5.8), Brain - Cerebellar Hemisphere (x5.7), Brain - Frontal Cortex (BA9) (x5.7), Brain - Amygdala (x5.1), Brain - Cerebellum (x4.4), and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for GPRIN1 Gene

This gene is overexpressed in Brain (27.6), Pancreas (15.3), Fetal Brain (12.6), and Frontal cortex (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPRIN1 Gene

Protein tissue co-expression partners for GPRIN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPRIN1 Gene:


SOURCE GeneReport for Unigene cluster for GPRIN1 Gene:


mRNA Expression by UniProt/SwissProt for GPRIN1 Gene:

Tissue specificity: Widely expressed in the central nervous system, with highest levels in spinal cord.
genes like me logo Genes that share expression patterns with GPRIN1: view

Primer Products

Orthologs for GPRIN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPRIN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPRIN1 34 35
  • 79.39 (n)
(Canis familiaris)
Mammalia GPRIN1 34 35
  • 78.03 (n)
(Rattus norvegicus)
Mammalia Gprin1 34
  • 73.03 (n)
(Mus musculus)
Mammalia Gprin1 34 16 35
  • 72.6 (n)
(Pan troglodytes)
Mammalia GPRIN1 35
  • 50 (a)
(Monodelphis domestica)
Mammalia GPRIN1 35
  • 41 (a)
(Gallus gallus)
Aves GPRIN1 35
  • 27 (a)
(Anolis carolinensis)
Reptilia GPRIN1 35
  • 46 (a)
(Danio rerio)
Actinopterygii GPRIN1 35
  • 19 (a)
Species where no ortholog for GPRIN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPRIN1 Gene

Gene Tree for GPRIN1 (if available)
Gene Tree for GPRIN1 (if available)

Paralogs for GPRIN1 Gene

Paralogs for GPRIN1 Gene

genes like me logo Genes that share paralogs with GPRIN1: view

Variants for GPRIN1 Gene

Sequence variations from dbSNP and Humsavar for GPRIN1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10037225 -- 176,598,825(+) GAGCC(C/G)CGGTC reference, missense
rs10044781 -- 176,606,662(+) CAATC(A/G)TGGAA intron-variant
rs10055756 -- 176,604,283(+) GAGCT(A/G)GAGTG intron-variant
rs10057790 -- 176,605,023(+) ctacc(A/G)cgccc intron-variant
rs10057792 -- 176,605,044(+) TCCAT(A/G)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPRIN1 Gene

Variant ID Type Subtype PubMed ID
nsv1073939 CNV deletion 25765185
nsv1126732 CNV deletion 24896259
nsv471056 CNV loss 18288195
nsv600345 CNV loss 21841781
nsv600346 CNV loss 21841781

Variation tolerance for GPRIN1 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.91; 87.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPRIN1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPRIN1 Gene

Disorders for GPRIN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPRIN1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
psoriasis 14, pustular
  • pustulosis of palm and sole
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GPRIN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GPRIN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPRIN1 Gene

Publications for GPRIN1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. A candidate target for G protein action in brain. (PMID: 10480904) Chen L.T. … Kozasa T. (J. Biol. Chem. 1999) 3 4 64
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for GPRIN1 Gene

Sources for GPRIN1 Gene

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