Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPRC6A Gene

protein-coding   GIFtS: 56
GCID: GC06M117158

G Protein-Coupled Receptor, Family C, Group 6, Member A

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
G Protein-Coupled Receptor, Family C, Group 6, Member A1 2     bA86F4.32
G-Protein Coupled Receptor GPCR332 3     G-Protein Coupled Receptor Family C Group 6 Member A2
hGPCR332 3     Predicted With SOSUI Analysis2
hGPRC6A2 3     Seven Transmembrane Helix Receptor2
GPCR2     

External Ids:    HGNC: 185101   Entrez Gene: 2225452   Ensembl: ENSG000001736127   OMIM: 6135725   UniProtKB: Q5T6X53   

Export aliases for GPRC6A gene to outside databases

Previous GC identifers: GC06M116948 GC06M117136 GC06M117219 GC06M114692


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GPRC6A Gene:
Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an
evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region.
Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain (summary by Pi et al.,
2005 (PubMed 16199532)).(supplied by OMIM, Nov 2010)

GeneCards Summary for GPRC6A Gene: 
GPRC6A (G protein-coupled receptor, family C, group 6, member A) is a protein-coding gene. Diseases associated with GPRC6A include endocrine diseases, and hyperaldosteronism, and among its related super-pathways are Signaling by GPCR and Gastrin-CREB signalling pathway via PKC and MAPK. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GRM7.

UniProtKB/Swiss-Prot: GPC6A_HUMAN, Q5T6X5
Function: Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and
L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent
cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11)
and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates
nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin,
divalents ions and its responsiveness to anabolic steroids

Gene Wiki entry for GPRC6A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPRC6A gene promoter:
         IRF-2   SRY   C/EBPbeta   HOXA3   AML1a   Nkx2-2   CUTL1   Pax-4a   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPRC6A promoter sequence
   Search SABiosciences Chromatin IP Primers for GPRC6A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPRC6A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.1   Ensembl cytogenetic band:  6q22.1   HGNC cytogenetic band: 6q22.31

GPRC6A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPRC6A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M117158:  view genomic region     (about GC identifiers)

Start:
117,113,248 bp from pter      End:
117,150,200 bp from pter
Size:
36,953 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GPC6A_HUMAN, Q5T6X5 (See protein sequence)
Recommended Name: G-protein coupled receptor family C group 6 member A precursor  
Size: 926 amino acids; 104753 Da
Subunit: Homodimer; disulfide-linked (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)
Sequence caution: Sequence=BAC05904.1; Type=Erroneous gene model prediction;
Secondary accessions: Q6JK43 Q6JK44 Q8NGU8 Q8NHZ9 Q8TDT6
Alternative splicing: 3 isoforms:  Q5T6X5-1   Q5T6X5-2   Q5T6X5-3   (Major isoform)

Explore the universe of human proteins at neXtProt for GPRC6A: NX_Q5T6X5

Explore proteomics data for GPRC6A at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5T6X5

  • GPRC6A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GPRC6A Protein Expression
    REFSEQ proteins: NP_683766.2  
    ENSEMBL proteins: 
     ENSP00000309493   ENSP00000357537   ENSP00000433465  
    Reactome Protein details: Q5T6X5
    Human Recombinant Protein Products for GPRC6A: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GPRC6A
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for GPRC6A
    GenScript Custom Purified and Recombinant Proteins Services for GPRC6A
    Novus Biologicals GPRC6A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GPRC6A 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IEA--
    GO:0016021integral to membrane IEA--

    GPRC6A for ontologies           About GeneDecksing



    GPRC6A Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for GPRC6A
    OriGene Custom Antibody Services for GPRC6A
    GenScript Custom Superior Antibodies Services for GPRC6A
    Novus Biologicals GPRC6A Antibodies
    Abcam antibodies for GPRC6A
    Cloud-Clone Corp. Antibodies for GPRC6A 
    ThermoFisher Antibodies for GPRC6A
    LSBio Antibodies in human, mouse, rat for GPRC6A 

    Assay Products for GPRC6A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GPRC6A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GPRC6A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GPRC6A 
    Cloud-Clone Corp. CLIAs for GPRC6A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CASR: GPCR / Class C : Calcium-sensing receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPRC6 receptor 
    Calcium-sensing receptors

    5 InterPro protein domains:
     IPR011500 GPCR_3_9-Cys_dom
     IPR000337 GPCR_3
     IPR017979 GPCR_3_CS
     IPR017978 GPCR_3_C
     IPR001828 ANF_lig-bd_rcpt

    Graphical View of Domain Structure for InterPro Entry Q5T6X5

    ProtoNet protein and cluster: Q5T6X5

    2 Blocks protein domains:
    IPB000337 G-protein coupled receptors family 3 (Metabotropic glutamate receptor-like)
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GPC6A_HUMAN, Q5T6X5
    Similarity: Belongs to the G-protein coupled receptor 3 family


    GPRC6A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPC6A_HUMAN, Q5T6X5
    Function: Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and
    L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent
    cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11)
    and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates
    nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin,
    divalents ions and its responsiveness to anabolic steroids

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
         
    GPRC6A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GPRC6A:
     Cell cycle / mitosis defect 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gprc6a):
     adipose tissue  cellular  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     integument  liver/biliary system  renal/urinary system  reproductive system  skeleton 

    GPRC6A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gprc6atm1Ldq for GPRC6A

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GPRC6A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GPRC6A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GPRC6A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GPRC6A 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GPRC6A
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GPRC6A
    SwitchGear 3'UTR luciferase reporter plasmidGPRC6A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GPRC6A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPRC6A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GPRC6A
    Sirion Biotech Customized adenovirus for overexpression of GPRC6A

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GPRC6A (see all 6)
    OriGene ORF clones in mouse, rat for GPRC6A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GPRC6A (NM_148963)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPRC6A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPRC6A
    Sirion Biotech Customized lentivirus for stable overexpression of GPRC6A 
                         Customized lentivirus expression plasmids for stable overexpression of GPRC6A 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GPRC6A
    Search LifeMap BioReagents cell lines for GPRC6A
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPRC6A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GPRC6A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    3Class A/1 (Rhodopsin-like receptors)
    GPCR ligand binding0.71
    4Class C/3 (Metabotropic glutamate/pheromone receptors)
    Class C/3 (Metabotropic glutamate/pheromone receptors)0.45

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/7        Reactome Pathways for GPRC6A (see all 7)
        GPCR downstream signaling
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signal Transduction
    Class C/3 (Metabotropic glutamate/pheromone receptors)
    G alpha (q) signalling events



    GPRC6A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPRC6A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/123 Interacting proteins for GPRC6A (ENSP000003094934) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASRENSP000002961544STRING: ENSP00000296154
    CCKARENSP000002955894STRING: ENSP00000295589
    CIDEBENSP000003377314STRING: ENSP00000337731
    FFAR1ENSP000002465534STRING: ENSP00000246553
    FFAR2ENSP000002465494STRING: ENSP00000246549
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0019722calcium-mediated signaling IEA--
    GO:0043200response to amino acid stimulus IDA17478059

    GPRC6A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GPRC6A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GPRC6A (GPC6A)

    2 HMDB Compounds for GPRC6A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    UreaCarbonyl diamine (see all 90)57-13-6--

    8 IUPHAR Ligands for GPRC6A (GPRC6 receptor)    About this table 
    LigandTypeActionAffinityPubmed IDs
    L-arginine
    AgonistFull agonist4.415576628
    L-ornithine
    AgonistFull agonist415576628
    L-alanine
    AgonistFull agonist3.815576628
    L-lysine
    AgonistFull agonist3.815576628
    glycine
    AgonistFull agonist3.615576628
    L-citrulline
    AgonistFull agonist3.615576628
    L-serine
    AgonistFull agonist3.215576628
    L-glutamine
    AgonistFull agonist3.215576628

    10/33 Novoseek inferred chemical compound relationships for GPRC6A gene (see all 33)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cinacalcet 64.1 4 19305800 (1), 17266540 (1), 18220773 (1)
    glutamate 48.6 16 17537956 (2), 11133983 (1), 17959251 (1), 16754330 (1) (see all 15)
    tryptamine 37.9 2 17888514 (1)
    ag 1478 37.3 1 19615971 (1)
    calcium 29.2 37 16456221 (3), 15761211 (3), 17623778 (1), 10940638 (1) (see all 14)
    dopamine 25.6 1 12769803 (1)
    tyrosine 20.8 11 15488194 (2), 15282267 (1), 16319133 (1), 10915788 (1) (see all 8)
    gtp 20.4 5 11356949 (2), 15488186 (1)
    gdp 18 4 11356949 (2), 15488186 (1)
    adenylate 14.3 1 15282267 (1)

    Search CenterWatch for drugs/clinical trials and news about GPRC6A / GPC6A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GPRC6A gene: 
    NM_148963.2  

    Unigene Cluster for GPRC6A:

    G protein-coupled receptor, family C, group 6, member A
    Hs.266745  [show with all ESTs]
    Unigene Representative Sequence: AF502962
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310357(uc003pxj.1 uc003pxk.1 uc003pxl.1) ENST00000368549
    ENST00000530250
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GPRC6A
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GPRC6A
    SwitchGear 3'UTR luciferase reporter plasmidGPRC6A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GPRC6A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPRC6A
    Clone
    Products:
         
    OriGene clones in human, mouse for GPRC6A (see all 6)
    OriGene ORF clones in mouse, rat for GPRC6A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GPRC6A (NM_148963)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPRC6A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPRC6A
    Sirion Biotech Customized lentivirus for stable overexpression of GPRC6A 
                         Customized lentivirus expression plasmids for stable overexpression of GPRC6A 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GPRC6A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GPRC6A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPRC6A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPRC6A

    Additional mRNA sequence: 

    AF502962.1 AY435125.1 AY435126.1 AY435127.1 

    2 DOTS entries:

    DT.100007950  DT.102820285 

    8 AceView cDNA sequences:

    NM_148963 AW771483 AF502962 AY435126 BX280688 AY435127 AY435125 BG182090 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GPRC6A    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
    SP1:                    -                     
    SP2:                                          
    SP3:                          -               


    ECgene alternative splicing isoforms for GPRC6A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPRC6A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGCAAATT
    GPRC6A Expression
    About this image


    See GPRC6A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GPRC6A

    SOURCE GeneReport for Unigene cluster: Hs.266745

    UniProtKB/Swiss-Prot: GPC6A_HUMAN, Q5T6X5
    Tissue specificity: Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria,
    osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low
    level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon.
    Isoform 1 and isoform 2 are expressed in kidney at the same level. Isoform 2 is expressed at lower level than
    isoform 1 in the other tissues

        SABiosciences Expression via Pathway-Focused PCR Array including GPRC6A: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for GPRC6A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GPRC6A
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPRC6A
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPRC6A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPRC6A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GPRC6A gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gprc6a1 , 5 G protein-coupled receptor, family C, group 6, member more1, 5 82.79(n)1
    80.13(a)1
      10 (25.66 cM)5
    2101981  NM_153071.11  NP_694711.11 
     516148235 
    chicken
    (Gallus gallus)
    Aves GPRC6A1 G protein-coupled receptor, family C, group 6, member more 68.1(n)
    63.95(a)
      428620  XM_426177.2  XP_426177.2 
    lizard
    (Anolis carolinensis)
    Reptilia GPRC6A6
    Uncharacterized protein
    61(a)
    1 ↔ 1
    1(185888884-185912961)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX705326.12   -- 69.76(n)    BX705326.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gprc6a1 G protein-coupled receptor, family C, group 6, member more 54.18(n)
    46.49(a)
      494131  NM_001008731.1  NP_001008731.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mgl-16
    mgl-26
    (see all 3)
    Protein MGL-2
    (see all 3)
    21(a)
    19(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    X(9968629-9974402)
    I(10384219-10391395)


    ENSEMBL Gene Tree for GPRC6A (if available)
    TreeFam Gene Tree for GPRC6A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GPRC6A gene
    GRM72  GRM42  TAS1R22  GRM82  TAS1R32  GRM22  GRM32  TAS1R12  
    GRM62  GRM52  GRM12  
    5 SIMAP similar genes for GPRC6A using alignment to 1 protein entry:     GPC6A_HUMAN:
    GPCR    CASR    TAS1R1    TAS1R2    TAS1R3

    GPRC6A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/800 SNPs in GPRC6A are shown (see all 800)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1418806821,2
    --117112896(+) CATAGG/TAATTG 1 -- ds50010--------
    rs1813508791,2
    --117112995(+) GTCGGA/GAATGG 1 -- ds50010--------
    rs1462643031,2
    C--117113062(+) TGCCTA/GAGAGG 1 -- ds50010--------
    rs1407974441,2
    C--117113189(+) TTGGT-/AAAGAT 1 -- ds50010--------
    rs1865428891,2
    --117113205(+) CAAGGA/TAATAT 1 -- ds50010--------
    rs412908521,2
    C,F--117113315(+) TACTTG/AACATT 2 /S /L mis12Minor allele frequency- A:0.02NA EU 5805
    rs412908541,2
    C,F--117113365(+) TCCCTG/ACATAT 2 /C syn13Minor allele frequency- A:0.01NA EU 5961
    rs1445458991,2
    C,F--117113382(+) AAATGC/GTTGTG 2 P A mis11Minor allele frequency- G:0.00NA 4540
    rs412919121,2
    C,F--117113430(+) GCCACT/CAGAGC 2 /S /G mis11Minor allele frequency- C:0.00NA 4546
    rs1425182381,2
    C,F--117113432(+) CACTAG/TAGCTG 2 Y S mis12Minor allele frequency- T:0.00NA EU 5869

    HapMap Linkage Disequilibrium report for GPRC6A (117113248 - 117150200 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GPRC6A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv523972CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GPRC6A
    DNA2.0 Custom Variant and Variant Library Synthesis for GPRC6A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613572    OMIM disorders: --

    19 diseases for GPRC6A:    About MalaCards
    endocrine diseases    hyperaldosteronism    ocular albinism    hypercalcemia
    albinism    hyperparathyroidism    testicular cancer    pituitary tumors
    kaposi's sarcoma    prostate cancer, progression of    asthma    prostate cancer
    sarcoma    prostatitis    pancreatic cancer    adenoma
    hypertension    pancreatitis    neuronitis


    GPRC6A for disorders           About GeneDecksing

    10/14 Novoseek inferred disease relationships for GPRC6A gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperparathyroidism 26.3 1 18220773 (1)
    immunodeficiency 4.5 2 9303305 (1), 12958314 (1)
    cancer 3.96 3 20043076 (1), 20388847 (1), 16101380 (1)
    stroke 2.76 1 12769803 (1)
    prostate cancer 1.74 1 16101380 (1)
    tumors 0.426 1 16211229 (1)
    cardiovascular diseases 0 1 12382069 (1)
    asthma 0 6 16828259 (3), 16670762 (1), 11402033 (1)
    hypercalcemia 0 2 12970167 (2)
    epilepsy 0 1 12769803 (1)

    Genetic Association Database (GAD): GPRC6A
    Human Genome Epidemiology (HuGE) Navigator: GPRC6A (2 documents)

    Export disorders for GPRC6A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GPRC6A gene, integrated from 9 sources (see all 207):
    (articles sorted by number of sources associating them with GPRC6A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor. (PubMed id 15194188)1, 2, 9 Wellendorph P. and Braeuner-Osborne H. (2004)
    2. Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. (PubMed id 15576628)1, 2, 9 Wellendorph P.... Brauener-Osborne H. (2005)
    3. Meta-analysis of genome-wide association studies in & gt;80 000 subjects identifies multiple loci for C-reactive protein levels. (PubMed id 21300955)1, 4 Dehghan A....Chasman D.I. (2011)
    4. Genome-wide association study identifies five new sus ceptibility loci for prostate cancer in the Japanese population. (PubMed id 20676098)1, 4 Takata R....Nakagawa H. (2010)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (2002)
    7. Osteocalcin regulates murine and human fertility throu gh a pancreas-bone-testis axis. (PubMed id 23728177)1 Oury F....Karsenty G. (2013)
    8. The G protein-coupled receptor family C group 6 subtyp e A (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells. (PubMed id 23269670)1 Oya M....Tsuboi T. (2013)
    9. Extracellular Ca2+ is a danger signal activating the N LRP3 inflammasome through G protein-coupled calcium sensing receptors. (PubMed id 23271661)1 Rossol M....Wagner U. (2012)
    10. Replication and fine mapping for association of the C2 orf43, FOXP4, GPRC6A and RFX6 genes with prostate cancer in the Chinese populati on. (PubMed id 22662242)1 Long Q.Z....Liu X.G. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 222545 HGNC: 18510 AceView: GPRC6A Ensembl:ENSG00000173612 euGenes: HUgn222545
    ECgene: GPRC6A H-InvDB: GPRC6A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GPRC6A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GPRC6A gene:
    Search GeneIP for patents involving GPRC6A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GPRC6A   OriGene RNAi products in human, mouse, rat for GPRC6A  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for GPRC6A  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GPRC6A  
     OriGene qSTAR qPCR primer pairs in human, mouse for GPRC6A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GPRC6A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GPRC6A   OriGene Custom Protein Services for GPRC6A  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GPRC6A
     QIAGEN SeqTarget long-range PCR primers for resequencing GPRC6A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPRC6A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPRC6A
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPRC6A
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPRC6A
     GenScript Custom Purified and Recombinant Proteins Services for GPRC6A GenScript cDNA clones with any tag delivered in your preferred vector for GPRC6A
     GenScript Custom Assay Services for GPRC6A GenScript Custom Superior Antibodies Services for GPRC6A
     GenScript Custom overexpressing Cell Line Services for GPRC6A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in GPRC6A promoter
     Search Chromatin IP Primers for GPRC6A
     RT2 qPCR Primer Assay in human, mouse, rat GPRC6A
     Search GNC Networks for GPRC6A
     SABiosciences PCR Arrays including human, mouse, rat GPRC6A
     Search Tocris compounds for GPRC6A (GPC6A)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GPRC6A antibodies
     GPRC6A lysates
     Antibodies for GPRC6A
     See all of Abcam's Antibodies, Kits and Proteins for GPRC6A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for GPRC6A
     Antibodies for GPRC6A
     ELISAs for GPRC6A
     CLIAs for GPRC6A
     Search LifeMap BioReagents cell lines for GPRC6A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPRC6A
     SwitchGear 3'UTR luciferase reporter plasmids for GPRC6A
     SwitchGear Promoter luciferase reporter plasmids for GPRC6A
     ThermoFisher Antibodies for GPRC6A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPRC6A
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GPRC6A
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GPRC6A
    Customized:
     lentivirus for stable overexpression of GPRC6A
     lentivirus expression plasmids for stable overexpression of GPRC6A
     adenovirus for overexpression of GPRC6A
     LSBio Antibodies in human, mouse, rat for GPRC6A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GPRC6A gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4