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GPRC6A Gene

protein-coding   GIFtS: 56
GCID: GC06M117158

G Protein-Coupled Receptor, Class C, Group 6, Member A

(Previous names: G protein-coupled receptor, family C, group 6, member A)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
G Protein-Coupled Receptor, Class C, Group 6, Member A1 2     G-Protein Coupled Receptor Family C Group 6 Member A2
G Protein-Coupled Receptor, Family C, Group 6, Member A1 2     Predicted With SOSUI Analysis2
G-Protein Coupled Receptor GPCR332 3     Seven Transmembrane Helix Receptor2
GPCR2     hGPCR333
bA86F4.32     hGPRC6A3

External Ids:    HGNC: 185101   Entrez Gene: 2225452   Ensembl: ENSG000001736127   OMIM: 6135725   UniProtKB: Q5T6X53   

Export aliases for GPRC6A gene to outside databases

Previous GC identifers: GC06M116948 GC06M117136 GC06M117219 GC06M114692


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GPRC6A Gene:
Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an
evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region.
Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain (summary by Pi et al.,
2005 (PubMed 16199532)).(supplied by OMIM, Nov 2010)

GeneCards Summary for GPRC6A Gene:
GPRC6A (G protein-coupled receptor, class C, group 6, member A) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GRM7.

UniProtKB/Swiss-Prot: GPC6A_HUMAN, Q5T6X5
Function: Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and
L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent
cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11)
and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates
nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin,
divalents ions and its responsiveness to anabolic steroids

Gene Wiki entry for GPRC6A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPRC6A gene promoter:
         IRF-2   SRY   C/EBPbeta   HOXA3   AML1a   Nkx2-2   CUTL1   Pax-4a   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPRC6A promoter sequence
   Search Chromatin IP Primers for GPRC6A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPRC6A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.1   Ensembl cytogenetic band:  6q22.1   HGNC cytogenetic band: 6q22.31

GPRC6A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPRC6A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M117158:  view genomic region     (about GC identifiers)

Start:
117,113,248 bp from pter      End:
117,150,200 bp from pter
Size:
36,953 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GPC6A_HUMAN, Q5T6X5 (See protein sequence)
Recommended Name: G-protein coupled receptor family C group 6 member A precursor  
Size: 926 amino acids; 104753 Da
Subunit: Homodimer; disulfide-linked (By similarity)
Sequence caution: Sequence=BAC05904.1; Type=Erroneous gene model prediction;
Secondary accessions: Q6JK43 Q6JK44 Q8NGU8 Q8NHZ9 Q8TDT6
Alternative splicing: 3 isoforms:  Q5T6X5-1   Q5T6X5-2   Q5T6X5-3   (Major isoform)

Explore the universe of human proteins at neXtProt for GPRC6A: NX_Q5T6X5

Explore proteomics data for GPRC6A at MOPED

Post-translational modifications: 

  • N-glycosylated (By similarity)1
  • Glycosylation2 at Asn332, Asn567, Asn590, Asn733
  • Modification sites at PhosphoSitePlus

  • See GPRC6A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001273283.1  NP_001273284.1  NP_683766.2  

    ENSEMBL proteins: 
     ENSP00000309493   ENSP00000357537   ENSP00000433465  
    Reactome Protein details: Q5T6X5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CASR: GPCR / Class C : Calcium-sensing receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPRC6 receptor
    Calcium-sensing receptors

    Selected InterPro protein domains (see all 6):
     IPR011500 GPCR_3_9-Cys_dom
     IPR028082 Peripla_BP_I
     IPR000337 GPCR_3
     IPR017979 GPCR_3_CS
     IPR017978 GPCR_3_C

    Graphical View of Domain Structure for InterPro Entry Q5T6X5

    ProtoNet protein and cluster: Q5T6X5

    2 Blocks protein domains:
    IPB000337 G-protein coupled receptors family 3 (Metabotropic glutamate receptor-like)
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GPC6A_HUMAN, Q5T6X5
    Similarity: Belongs to the G-protein coupled receptor 3 family


    Find genes that share domains with GPRC6A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPC6A_HUMAN, Q5T6X5
    Function: Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and
    L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent
    cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11)
    and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates
    nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin,
    divalents ions and its responsiveness to anabolic steroids

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
         
    Find genes that share ontologies with GPRC6A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GPRC6A:
     Cell cycle / mitosis defect 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gprc6a):
     adipose tissue  cellular  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     integument  liver/biliary system  renal/urinary system  reproductive system  skeleton 

    Find genes that share phenotypes with GPRC6A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Gprc6atm1Ldq for GPRC6A

       genOway: Develop your customized and physiologically relevant rodent model for GPRC6A

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GPC6A_HUMAN, Q5T6X5: Cell membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with GPRC6A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GPRC6A About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    3Peptide ligand-binding receptors
    GPCR ligand binding0.71
    4Taste transduction
    Class C/3 (Metabotropic glutamate/pheromone receptors)0.45


    Find genes that share SuperPaths with GPRC6A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for GPRC6A
        G alpha (q) signalling events
    Class C/3 (Metabotropic glutamate/pheromone receptors)


        Pathway & Disease-focused RT2 Profiler PCR Array including GPRC6A: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GPRC6A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GPRC6A (ENSP000003094934) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASRENSP000002961544STRING: ENSP00000296154
    CCKARENSP000002955894STRING: ENSP00000295589
    CIDEBENSP000003377314STRING: ENSP00000337731
    FFAR1ENSP000002465534STRING: ENSP00000246553
    FFAR2ENSP000002465494STRING: ENSP00000246549
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0019722calcium-mediated signaling IEA--
    GO:0043200response to amino acid IDA17478059

    Find genes that share ontologies with GPRC6A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPRC6A (GPC6A)

    2 HMDB Compounds for GPRC6A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    UreaCarbonyl diamine (see all 90)57-13-6--

    8 IUPHAR Ligands for GPRC6A (GPRC6 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    L-arginine
    AgonistFull agonist4.415576628
    L-ornithine
    AgonistFull agonist415576628
    L-alanine
    AgonistFull agonist3.815576628
    L-lysine
    AgonistFull agonist3.815576628
    glycine
    AgonistFull agonist3.615576628
    L-citrulline
    AgonistFull agonist3.615576628
    L-serine
    AgonistFull agonist3.215576628
    L-glutamine
    AgonistFull agonist3.215576628

    Selected Novoseek inferred chemical compound relationships for GPRC6A gene (see all 33)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cinacalcet 64.1 4 19305800 (1), 17266540 (1), 18220773 (1)
    glutamate 48.6 16 17537956 (2), 11133983 (1), 17959251 (1), 16754330 (1) (see all 15)
    tryptamine 37.9 2 17888514 (1)
    ag 1478 37.3 1 19615971 (1)
    calcium 29.2 37 16456221 (3), 15761211 (3), 17623778 (1), 10940638 (1) (see all 14)
    dopamine 25.6 1 12769803 (1)
    tyrosine 20.8 11 15488194 (2), 15282267 (1), 16319133 (1), 10915788 (1) (see all 8)
    gtp 20.4 5 11356949 (2), 15488186 (1)
    gdp 18 4 11356949 (2), 15488186 (1)
    adenylate 14.3 1 15282267 (1)



    Find genes that share compounds with GPRC6A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GPRC6A gene (3 alternative transcripts): 
    NM_001286354.1  NM_001286355.1  NM_148963.3  

    Unigene Cluster for GPRC6A:

    G protein-coupled receptor, family C, group 6, member A
    Hs.266745  [show with all ESTs]
    Unigene Representative Sequence: AF502962
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310357(uc003pxj.1 uc003pxk.1 uc003pxl.1) ENST00000368549
    ENST00000530250
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    Additional mRNA sequence: 

    AF502962.1 AY435125.1 AY435126.1 AY435127.1 

    2 DOTS entries:

    DT.100007950  DT.102820285 

    8 AceView cDNA sequences:

    NM_148963 AF502962 AW771483 AY435125 AY435126 BX280688 AY435127 BG182090 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GPRC6A    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
    SP1:                    -                     
    SP2:                                          
    SP3:                          -               


    ECgene alternative splicing isoforms for GPRC6A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPRC6A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGCAAATT
    GPRC6A Expression
    About this image

    GPRC6A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPRC6A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.266745

    UniProtKB/Swiss-Prot: GPC6A_HUMAN, Q5T6X5
    Tissue specificity: Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria,
    osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low
    level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon.
    Isoform 1 and isoform 2 are expressed in kidney at the same level. Isoform 2 is expressed at lower level than
    isoform 1 in the other tissues

        Pathway & Disease-focused RT2 Profiler PCR Array including GPRC6A: 
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GPRC6A gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gprc6a1 , 5 G protein-coupled receptor, family C, group 6, member more1, 5 82.79(n)1
    80.13(a)1
      10 (25.66 cM)5
    2101981  NM_153071.11  NP_694711.11 
     516148235 
    chicken
    (Gallus gallus)
    Aves GPRC6A1 G protein-coupled receptor, family C, group 6, member more 67.25(n)
    62.36(a)
      428620  XM_426177.3  XP_426177.3 
    lizard
    (Anolis carolinensis)
    Reptilia GPRC6A6
    G protein-coupled receptor, family C, group 6, mem...
    61(a)
    1 ↔ 1
    1(185888884-185912961)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX705326.12   -- 69.76(n)    BX705326.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gprc6a1 G protein-coupled receptor, family C, group 6, member more 54.95(n)
    46.75(a)
      494131  NM_001008731.1  NP_001008731.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mtt6
    mangetout
    16(a)
    1 ↔ 1
    2R(4361461-4419799)


    ENSEMBL Gene Tree for GPRC6A (if available)
    TreeFam Gene Tree for GPRC6A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GPRC6A gene
    GRM72  GRM42  TAS1R22  GRM82  TAS1R32  GRM22  GRM32  TAS1R12  
    GRM62  GRM52  GRM12  
    5 SIMAP similar genes for GPRC6A using alignment to 1 protein entry:     GPC6A_HUMAN:
    GPCR    CASR    TAS1R1    TAS1R2    TAS1R3

    Find genes that share paralogs with GPRC6A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GPRC6A (see all 800)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1418806821,2
    --117112896(+) CATAGG/TAATTG 1 -- ds50010--------
    rs1813508791,2
    --117112995(+) GTCGGA/GAATGG 1 -- ds50010--------
    rs1462643031,2
    C--117113062(+) TGCCTA/GAGAGG 1 -- ds50010--------
    rs1407974441,2
    C--117113189(+) TTGGT-/AAAGAT 1 -- ds50010--------
    rs1865428891,2
    --117113205(+) CAAGGA/TAATAT 1 -- ds50010--------
    rs412908521,2
    C,F--117113315(+) TACTTG/AACATT 2 /S /L mis12Minor allele frequency- A:0.02NA EU 5805
    rs412908541,2
    C,F--117113365(+) TCCCTG/ACATAT 2 /C syn13Minor allele frequency- A:0.01NA EU 5961
    rs1445458991,2
    C,F--117113382(+) AAATGC/GTTGTG 2 P A mis11Minor allele frequency- G:0.00NA 4540
    rs412919121,2
    C,F--117113430(+) GCCACT/CAGAGC 2 /S /G mis11Minor allele frequency- C:0.00NA 4546
    rs1425182381,2
    C,F--117113432(+) CACTAG/TAGCTG 2 Y S mis12Minor allele frequency- T:0.00NA EU 5869

    HapMap Linkage Disequilibrium report for GPRC6A (117113248 - 117150200 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GPRC6A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv523972CNV Gain19592680

    Human Gene Mutation Database (HGMD): GPRC6A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPRC6A
    DNA2.0 Custom Variant and Variant Library Synthesis for GPRC6A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613572    OMIM disorders: --


    Find genes that share disorders with GPRC6A           About GenesLikeMe

    Selected Novoseek inferred disease relationships for GPRC6A gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperparathyroidism 26.3 1 18220773 (1)
    immunodeficiency 4.5 2 9303305 (1), 12958314 (1)
    cancer 3.96 3 20043076 (1), 20388847 (1), 16101380 (1)
    stroke 2.76 1 12769803 (1)
    prostate cancer 1.74 1 16101380 (1)
    tumors 0.426 1 16211229 (1)
    cardiovascular diseases 0 1 12382069 (1)
    asthma 0 6 16828259 (3), 16670762 (1), 11402033 (1)
    hypercalcemia 0 2 12970167 (2)
    epilepsy 0 1 12769803 (1)

    Genetic Association Database (GAD): GPRC6A
    Human Genome Epidemiology (HuGE) Navigator: GPRC6A (2 documents)

    Export disorders for GPRC6A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPRC6A gene, integrated from 10 sources (see all 207):
    (articles sorted by number of sources associating them with GPRC6A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor. (PubMed id 15194188)1, 2, 9 Wellendorph P. and Braeuner-Osborne H. (Gene 2004)
    2. Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. (PubMed id 15576628)1, 2, 9 Wellendorph P.... Brauener-Osborne H. (Mol. Pharmacol. 2005)
    3. Meta-analysis of genome-wide association studies in &gt;80 000 subjects identifies multiple loci for C-reactive protein levels. (PubMed id 21300955)1, 4 Dehghan A....Chasman D.I. (Circulation 2011)
    4. Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. (PubMed id 20676098)1, 4 Takata R....Nakagawa H. (Nat. Genet. 2010)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    6. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (FEBS Lett. 2002)
    7. Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis. (PubMed id 23728177)1 Oury F....Karsenty G. (J. Clin. Invest. 2013)
    8. The G protein-coupled receptor family C group 6 subtype A (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells. (PubMed id 23269670)1 Oya M....Tsuboi T. (J. Biol. Chem. 2013)
    9. Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors. (PubMed id 23271661)1 Rossol M....Wagner U. (Nat Commun 2012)
    10. Replication and fine mapping for association of the C2orf43, FOXP4, GPRC6A and RFX6 genes with prostate cancer in the Chinese population. (PubMed id 22662242)1 Long Q.Z....Liu X.G. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 222545 HGNC: 18510 AceView: GPRC6A Ensembl:ENSG00000173612 euGenes: HUgn222545
    ECgene: GPRC6A H-InvDB: GPRC6A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GPRC6A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GPRC6A gene:
    Search GeneIP for patents involving GPRC6A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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