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Aliases for GPRC6A Gene

Aliases for GPRC6A Gene

  • G Protein-Coupled Receptor Class C Group 6 Member A 2 3
  • G Protein-Coupled Receptor, Class C, Group 6, Member A 2 3 5
  • G Protein-Coupled Receptor, Family C, Group 6, Member A 2 3
  • G-Protein Coupled Receptor GPCR33 3 4
  • Seven Transmembrane Helix Receptor 3
  • Predicted With SOSUI Analysis 3
  • BA86F4.3 3
  • HGPCR33 4
  • HGPRC6A 4
  • GPCR 3

External Ids for GPRC6A Gene

Previous GeneCards Identifiers for GPRC6A Gene

  • GC06M116948
  • GC06M117136
  • GC06M117158
  • GC06M117219
  • GC06M114692

Summaries for GPRC6A Gene

Entrez Gene Summary for GPRC6A Gene

  • Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain (summary by Pi et al., 2005 [PubMed 16199532]).[supplied by OMIM, Nov 2010]

GeneCards Summary for GPRC6A Gene

GPRC6A (G Protein-Coupled Receptor Class C Group 6 Member A) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GRM1.

UniProtKB/Swiss-Prot for GPRC6A Gene

  • Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids.

Gene Wiki entry for GPRC6A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPRC6A Gene

Genomics for GPRC6A Gene

Regulatory Elements for GPRC6A Gene

Genomic Location for GPRC6A Gene

Chromosome:
6
Start:
116,792,085 bp from pter
End:
116,829,057 bp from pter
Size:
36,973 bases
Orientation:
Minus strand

Genomic View for GPRC6A Gene

Genes around GPRC6A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPRC6A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPRC6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPRC6A Gene

Proteins for GPRC6A Gene

  • Protein details for GPRC6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T6X5-GPC6A_HUMAN
    Recommended name:
    G-protein coupled receptor family C group 6 member A
    Protein Accession:
    Q5T6X5
    Secondary Accessions:
    • Q6JK43
    • Q6JK44
    • Q8NGU8
    • Q8NHZ9
    • Q8TDT6

    Protein attributes for GPRC6A Gene

    Size:
    926 amino acids
    Molecular mass:
    104753 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.
    SequenceCaution:
    • Sequence=BAC05904.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for GPRC6A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPRC6A Gene

Proteomics data for GPRC6A Gene at MOPED

Post-translational modifications for GPRC6A Gene

Other Protein References for GPRC6A Gene

Antibody Products

No data available for DME Specific Peptides for GPRC6A Gene

Domains & Families for GPRC6A Gene

Gene Families for GPRC6A Gene

Suggested Antigen Peptide Sequences for GPRC6A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T6X5

UniProtKB/Swiss-Prot:

GPC6A_HUMAN :
  • Belongs to the G-protein coupled receptor 3 family.
Family:
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GPRC6A: view

Function for GPRC6A Gene

Molecular function for GPRC6A Gene

UniProtKB/Swiss-Prot Function:
Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids.
genes like me logo Genes that share phenotypes with GPRC6A: view

Animal Models for GPRC6A Gene

MGI Knock Outs for GPRC6A:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPRC6A Gene

Localization for GPRC6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPRC6A Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPRC6A Gene COMPARTMENTS Subcellular localization image for GPRC6A gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for GPRC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with GPRC6A: view

Pathways & Interactions for GPRC6A Gene

genes like me logo Genes that share pathways with GPRC6A: view

Interacting Proteins for GPRC6A Gene

Gene Ontology (GO) - Biological Process for GPRC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPRC6A: view

No data available for SIGNOR curated interactions for GPRC6A Gene

Drugs & Compounds for GPRC6A Gene

(23) Drugs for GPRC6A Gene - From: IUPHAR, DGIdb, Novoseek, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ornithine Approved Nutra Full agonist, Agonist 63
Citrulline Approved Nutra Full agonist, Agonist 0
Glycine Approved Nutra Full agonist, Agonist, antagonist Endogenous potentiator, co-transmitter 94
L-Alanine Approved Nutra Full agonist, Agonist, inhibitor Glycine receptor agonist 0
L-Arginine Approved Nutra Full agonist, Agonist 0

(18) Additional Compounds for GPRC6A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GPRC6A: view

Transcripts for GPRC6A Gene

mRNA/cDNA for GPRC6A Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPRC6A Gene

G protein-coupled receptor, family C, group 6, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPRC6A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: -
SP2:
SP3: -

Relevant External Links for GPRC6A Gene

GeneLoc Exon Structure for
GPRC6A
ECgene alternative splicing isoforms for
GPRC6A

Expression for GPRC6A Gene

mRNA expression in normal human tissues for GPRC6A Gene

mRNA differential expression in normal tissues according to GTEx for GPRC6A Gene

This gene is overexpressed in Minor Salivary Gland (x25.2), Adrenal Gland (x12.4), and Kidney - Cortex (x7.3).

Protein differential expression in normal tissues from HIPED for GPRC6A Gene

This gene is overexpressed in Monocytes (64.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPRC6A Gene



SOURCE GeneReport for Unigene cluster for GPRC6A Gene Hs.266745

mRNA Expression by UniProt/SwissProt for GPRC6A Gene

Q5T6X5-GPC6A_HUMAN
Tissue specificity: Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon. Isoform 1 and isoform 2 are expressed in kidney at the same level. Isoform 2 is expressed at lower level than isoform 1 in the other tissues.
genes like me logo Genes that share expression patterns with GPRC6A: view

Protein tissue co-expression partners for GPRC6A Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GPRC6A Gene

Orthologs for GPRC6A Gene

This gene was present in the common ancestor of animals.

Orthologs for GPRC6A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPRC6A 35
  • 99.32 (n)
  • 98.7 (a)
GPRC6A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPRC6A 35
  • 83.93 (n)
  • 76.26 (a)
dog
(Canis familiaris)
Mammalia GPRC6A 35
  • 89.13 (n)
  • 87.04 (a)
GPRC6A 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gprc6a 16
Gprc6a 36
  • 80 (a)
OneToOne
Gprc6a 35
  • 82.79 (n)
  • 80.13 (a)
oppossum
(Monodelphis domestica)
Mammalia GPRC6A 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 22 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Gprc6a 35
  • 81.86 (n)
  • 80.13 (a)
chicken
(Gallus gallus)
Aves GPRC6A 35
  • 67.25 (n)
  • 62.36 (a)
GPRC6A 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPRC6A 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487890 35
  • 62.28 (n)
  • 55.74 (a)
zebrafish
(Danio rerio)
Actinopterygii gprc6a 36
  • 42 (a)
OneToOne
gprc6a 35
  • 54.95 (n)
  • 46.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta mtt 36
  • 16 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToOne
Species with no ortholog for GPRC6A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPRC6A Gene

ENSEMBL:
Gene Tree for GPRC6A (if available)
TreeFam:
Gene Tree for GPRC6A (if available)

Paralogs for GPRC6A Gene

Paralogs for GPRC6A Gene

(5) SIMAP similar genes for GPRC6A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPRC6A: view

Variants for GPRC6A Gene

Sequence variations from dbSNP and Humsavar for GPRC6A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2274911 - 116,809,541(-) TCTTA(C/T)CTGGA reference, missense
rs28360548 - 116,809,381(+) AACCT(A/C)TGACA reference, missense
rs35937022 - 116,793,127(+) AGAGA(A/G)TCAGG reference, missense
rs615199 -- 116,792,490(+) ACAGC(C/T)GGTAC reference, synonymous-codon
rs1512657 -- 116,796,465(+) GAACC(C/G)TAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPRC6A Gene

Variant ID Type Subtype PubMed ID
nsv523972 CNV Gain 19592680

Variation tolerance for GPRC6A Gene

Residual Variation Intolerance Score: 97.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.80; 97.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPRC6A Gene

HapMap Linkage Disequilibrium report
GPRC6A
Human Gene Mutation Database (HGMD)
GPRC6A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPRC6A Gene

Disorders for GPRC6A Gene

Relevant External Links for GPRC6A

Genetic Association Database (GAD)
GPRC6A
Human Genome Epidemiology (HuGE) Navigator
GPRC6A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPRC6A

No disorders were found for GPRC6A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPRC6A Gene

Publications for GPRC6A Gene

  1. Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor. (PMID: 15194188) Wellendorph P. … Braeuner-Osborne H. (Gene 2004) 3 4 23 67
  2. Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. (PMID: 15576628) Wellendorph P. … Brauener-Osborne H. (Mol. Pharmacol. 2005) 3 23
  3. Testosterone stimulates Duox1 activity through GPRC6A in skin keratinocytes. (PMID: 25164816) Ko E. … Bae Y.S. (J. Biol. Chem. 2014) 3
  4. L-arginine stimulates fibroblast proliferation through the GPRC6A-ERK1/2 and PI3K/Akt pathway. (PMID: 24651445) Fujiwara T. … Hosokawa K. (PLoS ONE 2014) 3
  5. Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis. (PMID: 23728177) Oury F. … Karsenty G. (J. Clin. Invest. 2013) 3

Products for GPRC6A Gene

Sources for GPRC6A Gene

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