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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPRC5D Gene

protein-coding   GIFtS: 52
GCID: GC12M013093

G Protein-Coupled Receptor, Family C, Group 5, Member D

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
G Protein-Coupled Receptor, Family C, Group 5, Member D1 2
G-Protein Coupled Receptor Family C Group 5 Member D2
Orphan G-Protein Coupled Receptor2

External Ids:    HGNC: 133101   Entrez Gene: 555072   Ensembl: ENSG000001112917   OMIM: 6074375   UniProtKB: Q9NZD13   

Export aliases for GPRC5D gene to outside databases

Previous GC identifers: GC12M012824 GC12M013238 GC12M012993 GC12M012985 GC12M012986 GC12M012987


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GPRC5D Gene:
The protein encoded by this gene is a member of the G protein-coupled receptor family; however, the specific
function of this gene has not yet been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for GPRC5D Gene: 
GPRC5D (G protein-coupled receptor, family C, group 5, member D) is a protein-coding gene. Diseases associated with GPRC5D include hyperparathyroidism, and multiple myeloma, and among its related super-pathways are Synaptic Neurotransmission: Glutamatergic Excitation. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPRC5A.

Gene Wiki entry for GPRC5D Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPRC5D gene promoter:
         RP58   CUTL1   Gfi-1   FAC1   PPAR-gamma1   POU2F1   POU2F1b   POU2F1a   POU2F1c   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPRC5D promoter sequence
   Search SABiosciences Chromatin IP Primers for GPRC5D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPRC5D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3   Ensembl cytogenetic band:  12p13.1   HGNC cytogenetic band: 12p13.3

GPRC5D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPRC5D gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M013093:  view genomic region     (about GC identifiers)

Start:
13,093,709 bp from pter      End:
13,105,081 bp from pter
Size:
11,373 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GPC5D_HUMAN, Q9NZD1 (See protein sequence)
Recommended Name: G-protein coupled receptor family C group 5 member D  
Size: 345 amino acids; 38791 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q3KNV3 Q7Z5J9 Q8TDS6
Alternative splicing: 3 isoforms:  Q9NZD1-1   Q9NZD1-2   Q9NZD1-3   

Explore the universe of human proteins at neXtProt for GPRC5D: NX_Q9NZD1

Explore proteomics data for GPRC5D at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NZD1

  • GPRC5D Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GPRC5D Protein Expression
    REFSEQ proteins: NP_061124.1  
    ENSEMBL proteins: 
     ENSP00000228887   ENSP00000379624   ENSP00000440530  

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    Cloud-Clone Corp. Proteins for GPRC5D 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane NAS11311935
    GO:0016021integral to membrane IEA--

    GPRC5D for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GPCRCO: GPCR / Class C : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPRC5D 
    Class C Orphans

    1 InterPro protein domain:
     IPR017978 GPCR_3_C

    Graphical View of Domain Structure for InterPro Entry Q9NZD1

    ProtoNet protein and cluster: Q9NZD1

    UniProtKB/Swiss-Prot: GPC5D_HUMAN, Q9NZD1
    Similarity: Belongs to the G-protein coupled receptor 3 family


    GPRC5D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
         
    GPRC5D for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GPRC5D:
     Increased 8N DNA content 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GPRC5D About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Synaptic Neurotransmission: Glutamatergic Excitation
    GPCRs, Class C Metabotropic glutamate, pheromone0.33


    1 BioSystems Pathway for GPRC5D
        GPCRs, Class C Metabotropic glutamate, pheromone


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPRC5D

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    GPRC5D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GPRC5D (GPC5D)

    Search CenterWatch for drugs/clinical trials and news about GPRC5D / GPC5D

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GPRC5D gene: 
    NM_018654.1  

    Unigene Cluster for GPRC5D:

    G protein-coupled receptor, family C, group 5, member D
    Hs.644599  [show with all ESTs]
    Unigene Representative Sequence: BC069341
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000228887(uc010shp.2) ENST00000396333 ENST00000541128
    miRNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPRC5D
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    Additional mRNA sequence: 

    AB099817.1 AF209923.1 BC069341.1 BC107077.1 BC107078.1 

    3 DOTS entries:

    DT.91712671  DT.99990800  DT.91887162 

    11 AceView cDNA sequences:

    NM_018654 AF209923 BC069341 AB099817 BI039311 CD246158 BV187540 BF175459 
    BF371560 BF371549 BQ317906 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPRC5D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTTTTCCTG
    GPRC5D Expression
    About this image


    See GPRC5D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GPRC5D

    SOURCE GeneReport for Unigene cluster: Hs.644599

    UniProtKB/Swiss-Prot: GPC5D_HUMAN, Q9NZD1
    Tissue specificity: Widely expressed in the peripheral system. Expression pattern is high in pancreas, medium in
    kidney, small intestine, spleen and testis, low in lung, colon, leukocyte, prostate and thymus and not detectable
    in brain, heart, liver, placenta, skeletal muscle and ovary

        SABiosciences Expression via Pathway-Focused PCR Array including GPRC5D: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPRC5D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GPRC5D gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gprc5d1 , 5 G protein-coupled receptor, family C, group 5, member more1, 5 84.45(n)1
    81.63(a)1
      6 (65.89 cM)5
    937461  NM_001205396.11  NP_001192325.11 
     1351059915 
    chicken
    (Gallus gallus)
    Aves GPRC5A6
    Uncharacterized protein
    46(a)
    1 → many
    1(48080775-48086278)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    45(a)
    38(a)
    many ↔ many
    many ↔ many
    5(27524193-27540301)
    5(27489654-27503740)
    zebrafish
    (Danio rerio)
    Actinopterygii GPRC5D6
    G protein-coupled receptor, family C, group 5, mem...
    28(a)
    1 → many
    3(2111841-2114005)


    ENSEMBL Gene Tree for GPRC5D (if available)
    TreeFam Gene Tree for GPRC5D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GPRC5D gene
    GPRC5A2  GPRC5B2  GPRC5C2  
    3 SIMAP similar genes for GPRC5D using alignment to 2 protein entries:     GPC5D_HUMAN (see all proteins):
    GPRC5A    GPRC5C    GPRC5B

    GPRC5D for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/386 SNPs in GPRC5D are shown (see all 386)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1426276121,2
    Cuntested113102545(+) GGGACG/AATGTA 2 /I syn11Minor allele frequency- A:0.00NA 4552
    rs12913461,2
    C,F,A,H--13093279(-) ctcaaC/Tcatgt 1 -- ds500124Minor allele frequency- T:0.45NS EA NA WA CSA 2345
    rs1408900131,2
    --13093288(+) AGATGA/GTGAAG 1 -- ds50010--------
    rs1887968021,2
    --13093305(+) TTCTGC/TGTTTT 1 -- ds50010--------
    rs12913451,2
    C,F,O,A,H--13093342(-) TGGGTT/CACATG 1 -- ds500130Minor allele frequency- C:0.45NS EA NA WA CSA 2911
    rs1814826401,2
    --13093348(+) ACCCAC/GTAGTA 1 -- ds50010--------
    rs12913441,2
    C,F,A,H--13093385(-) AGGGCA/TTTCTA 1 -- ds500130Minor allele frequency- T:0.16MN NS EA NA CSA WA 3303
    rs1870763141,2
    --13093495(+) AAAGAG/TACACA 1 -- ds50010--------
    rs732885521,2
    C,F--13093657(+) GGGCTG/ATGCTA 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs745288391,2
    C--13093670(+) CAGGAC/TGGTCT 1 -- ds50012Minor allele frequency- T:0.08CSA WA 120

    HapMap Linkage Disequilibrium report for GPRC5D (13093709 - 13105081 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GPRC5D:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745567CNV Deletion23290073
    nsv520173CNV Loss19592680
    nsv832333CNV Gain17160897
    nsv898814CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607437    OMIM disorders: --

    4 diseases for GPRC5D:    About MalaCards
    hyperparathyroidism    multiple myeloma    myeloma    prostatitis


    GPRC5D for disorders           About GeneDecksing

    Genetic Association Database (GAD): GPRC5D
    Human Genome Epidemiology (HuGE) Navigator: GPRC5D (1 document)

    Export disorders for GPRC5D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GPRC5D gene integrated from 9 sources:
    (articles sorted by number of sources associating them with GPRC5D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. (PubMed id 11311935)1, 2, 9 Braeuner-Osborne H.... O'Hara P. (2001)
    2. L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (2002)
    5. Overexpression of G protein-coupled receptor 5D in the bone marrow is associated with poor prognosis in patients with multiple myeloma . (PubMed id 22591013)1 Atamaniuk J....Gaiger A. (2012)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55507 HGNC: 13310 AceView: GPRC5D Ensembl:ENSG00000111291 euGenes: HUgn55507
    ECgene: GPRC5D H-InvDB: GPRC5D

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GPRC5D Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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