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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GPRC5D Gene

protein-coding GIFtS: 49
GCID: GC12M013093

G protein-coupled receptor, family C, group 5, member D

Explore 1 disease affiliated with
GPRC5D via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
G Protein-Coupled Receptor, Family C, Group 5, Member D¹ ²
G-Protein Coupled Receptor Family C Group 5 Member D²
Orphan G-Protein Coupled Receptor²

External Ids:	HGNC: 13310¹	Entrez Gene: 55507²	Ensembl: ENSG00000111291⁷	OMIM: 607437⁵	UniProtKB: Q9NZD1³

Export aliases for GPRC5D gene to outside databases

Previous GC identifers: GC12M012824 GC12M013238 GC12M012993 GC12M012985 GC12M012986 GC12M012987

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GPRC5D:

The protein encoded by this gene is a member of the G protein-coupled receptor family; however, the specific function

of this gene has not yet been determined. (provided by RefSeq, Jul 2008)

Gene Wiki entry for GPRC5D

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GPRC5D gene promoter:
RP58 CUTL1 Gfi-1 FAC1 PPAR-gamma1 POU2F1 POU2F1b POU2F1a POU2F1c PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GPRC5D promoter sequence

Search SABiosciences Chromatin IP Primers for GPRC5D

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPRC5D

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3 Ensembl cytogenetic band: 12p13.1 HGNC cytogenetic band: 12p13.3

GPRC5D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPRC5D gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M013093: view genomic region (about GC identifiers)

Start:	13,093,709 bp from pter	End:	13,105,081 bp from pter
Size:	11,373 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GPC5D_HUMAN, Q9NZD1 (See protein sequence)

Recommended Name: G-protein coupled receptor family C group 5 member D

Size: 345 amino acids; 38791 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q3KNV3 Q7Z5J9 Q8TDS6

Alternative splicing: 3 isoforms: Q9NZD1-1 Q9NZD1-2 Q9NZD1-3

Explore the universe of human proteins at neXtProt for GPRC5D: NX_Q9NZD1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NZD1

GPRC5D Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_061124.1

ENSEMBL proteins:

ENSP00000228887 ENSP00000379624 ENSP00000440530

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	NAS	11311935
GO:0016021	integral to membrane	IEA	--

GPRC5D for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GPRC5D for domains About GeneDecksing

1 InterPro domain/family:

IPR017978 GPCR_3_C

Graphical View of Domain Structure for InterPro Entry Q9NZD1

ProtoNet protein and cluster: Q9NZD1

UniProtKB/Swiss-Prot: GPC5D_HUMAN, Q9NZD1

Similarity: Belongs to the G-protein coupled receptor 3 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	IEA	--

GPRC5D for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for GPRC5D:

Increased 8N DNA content

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class C/3 (Metabotropic glutamate/pheromone receptors)

GPCRs, Class C Metabotropic glutamate, pheromone

0.58

1 BioSystems Pathway for GPRC5D

GPCRs, Class C Metabotropic glutamate, pheromone

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GPRC5D

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for GPRC5D
Search CenterWatch for drugs/clinical trials and news about GPRC5D / GPC5D

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for GPRC5D gene:

NM_018654.1

Unigene Cluster for GPRC5D:

G protein-coupled receptor, family C, group 5, member D

Hs.644599 [show with all ESTs]

Unigene Representative Sequence: BC069341

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000228887(uc010shp.2) ENST00000396333 ENST00000541128

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Additional cDNA sequence:

AB099817.1 AF209923.1 BC069341.1 BC107077.1 BC107078.1

3 DOTS entries:

DT.91712671 DT.99990800 DT.91887162

11 AceView cDNA sequences:

BC069341 AF209923 NM_018654 BV187540 AB099817 CD246158 BI039311 BF175459

BF371560 BF371549 BQ317906

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GPRC5D expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTTTTCCTG

About this image
See GPRC5D Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GPRC5D

SOURCE GeneReport for Unigene cluster: Hs.644599

UniProtKB/Swiss-Prot: GPC5D_HUMAN, Q9NZD1

Tissue specificity: Widely expressed in the peripheral system. Expression pattern is high in pancreas, medium in

kidney, small intestine, spleen and testis, low in lung, colon, leukocyte, prostate and thymus and not detectable in

brain, heart, liver, placenta, skeletal muscle and ovary

SABiosciences Expression via Pathway-Focused PCR Array including GPRC5D:

G Protein Coupled Receptors 384HT in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for GPRC5D gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Gprc5d^{1 , 5}	G protein-coupled receptor, family C, group 5, member more^{1, 5}	84.45(n)¹ 81.63(a)¹		6 (65.89 cM)⁵ 93746¹ NM_001205396.1¹ NP_001192325.1¹ 135105991⁵
chicken (Gallus gallus)	Aves	GPRC5A⁶	Uncharacterized protein	45(a)	1 → many	1(50100860-50103948)
lizard (Anolis carolinensis)	Reptilia	-- --	--	45(a) 44(a)	many ↔ many many ↔ many	5(27500180-27500995) 5(27527761-27532414)
zebrafish (Danio rerio)	Actinopterygii	CABZ01109019.1⁶	--	28(a)	1 → many	3(2111841-2114005)

ENSEMBL Gene Tree for GPRC5D (if available)
TreeFam Gene Tree for GPRC5D (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GPRC5D gene

GPRC5A² GPRC5B² GPRC5C²

3 SIMAP similar genes for GPRC5D using alignment to 2 protein entries: GPC5D_HUMAN (see all proteins):

GPRC5A GPRC5C GPRC5B

GPRC5D for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142627612^1,2	C	other	13102545(+)	`GGGACG/AATGTA`	2	/I	syn¹		1		NA	4552
rs1291346^1,2	C,F,A,H,	--	13093279(-)	`CTCAAC/TCATGT`	1	--	ds500¹		24		NS EA NA WA CSA	2345
rs140890013^1,2		--	13093288(+)	`AGATGA/GTGAAG`	1	--	ds500¹		0	--	--	--	--
rs188796802^1,2		--	13093305(+)	`TTCTGC/TGTTTT`	1	--	ds500¹		0	--	--	--	--
rs1291345^1,2	C,F,O,A,H,	--	13093342(-)	`TGGGTT/CACATG`	1	--	ds500¹		30		NS EA NA WA CSA	2911
rs181482640^1,2		--	13093348(+)	`ACCCAC/GTAGTA`	1	--	ds500¹		0	--	--	--	--
rs1291344^1,2	C,F,A,H,	--	13093385(-)	`AGGGCA/TTTCTA`	1	--	ds500¹		30		MN NS EA NA CSA WA	3303
rs187076314^1,2		--	13093495(+)	`AAAGAG/TACACA`	1	--	ds500¹		0	--	--	--	--
rs73288552^1,2	C,	--	13093657(+)	`GGGCTG/ATGCTA`	1	--	ds500¹		1		WA	2
rs74528839^1,2	C,	--	13093670(+)	`CAGGAC/TGGTCT`	1	--	ds500¹		2		CSA WA	120

HapMap Linkage Disequilibrium report for GPRC5D (13093709 - 13105081 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GPRC5D: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GPRC5D for disorders           About GeneDecksing

OMIM gene information: 607437    OMIM disorders: --

1 disease for GPRC5D:    About MalaCards

prostatitis

Human Genome Epidemiology (HuGE) Navigator: GPRC5D (1 document)

Export disorders for GPRC5D gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for GPRC5D gene integrated from 9 sources:
(articles sorted by number of sources associating them with GPRC5D)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. (PubMed id 11311935)^{1, 2, 9} Braeuner-Osborne H.... O'Hara P. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)^{1, 2} Takeda S.... Mitaku S. (2002)
Overexpression of G protein-coupled receptor 5D in the bone marrow is associated with poor prognosis in patients with multiple myeloma . (PubMed id 22591013)¹ Atamaniuk J....Gaiger A. (2012)
L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)¹ Yokoyama K....Hosoya T. (2010)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55507	HGNC: 13310	AceView: GPRC5D	Ensembl:ENSG00000111291	euGenes: HUgn55507
ECgene: GPRC5D	H-InvDB: GPRC5D

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GPRC5D	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GPRC5D gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for GPRC5D gene:
Search GeneIP for patents involving GPRC5D

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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GPRC5D Gene

G protein-coupled receptor, family C, group 5, member D

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GPRC5D Gene

G protein-coupled receptor, family C, group 5, member D

Aliasesfor GPRC5D gene

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for GPRC5D gene

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