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GPRC5D Gene

protein-coding   GIFtS: 51
GCID: GC12M013093

G Protein-Coupled Receptor, Class C, Group 5, Member D

(Previous names: G protein-coupled receptor, family C, group 5, member D)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
G Protein-Coupled Receptor, Class C, Group 5, Member D1 2
G Protein-Coupled Receptor, Family C, Group 5, Member D1 2
G-Protein Coupled Receptor Family C Group 5 Member D2
Orphan G-Protein Coupled Receptor2

External Ids:    HGNC: 133101   Entrez Gene: 555072   Ensembl: ENSG000001112917   OMIM: 6074375   UniProtKB: Q9NZD13   

Export aliases for GPRC5D gene to outside databases

Previous GC identifers: GC12M012824 GC12M013238 GC12M012993 GC12M012985 GC12M012986 GC12M012987


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GPRC5D Gene:
The protein encoded by this gene is a member of the G protein-coupled receptor family; however, the specific
function of this gene has not yet been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for GPRC5D Gene:
GPRC5D (G protein-coupled receptor, class C, group 5, member D) is a protein-coding gene. Diseases associated with GPRC5D include hyperparathyroidism, and multiple myeloma. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPRC5A.

Gene Wiki entry for GPRC5D Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPRC5D gene promoter:
         RP58   CUTL1   Gfi-1   FAC1   PPAR-gamma1   POU2F1   POU2F1b   POU2F1a   POU2F1c   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPRC5D promoter sequence
   Search Chromatin IP Primers for GPRC5D

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPRC5D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3   Ensembl cytogenetic band:  12p13.1   HGNC cytogenetic band: 12p13.3

GPRC5D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPRC5D gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M013093:  view genomic region     (about GC identifiers)

Start:
13,093,709 bp from pter      End:
13,105,081 bp from pter
Size:
11,373 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GPC5D_HUMAN, Q9NZD1 (See protein sequence)
Recommended Name: G-protein coupled receptor family C group 5 member D  
Size: 345 amino acids; 38791 Da
Secondary accessions: Q3KNV3 Q7Z5J9 Q8TDS6
Alternative splicing: 3 isoforms:  Q9NZD1-1   Q9NZD1-2   Q9NZD1-3   

Explore the universe of human proteins at neXtProt for GPRC5D: NX_Q9NZD1

Explore proteomics data for GPRC5D at MOPED


See GPRC5D Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_061124.1  
ENSEMBL proteins: 
 ENSP00000228887   ENSP00000379624   ENSP00000440530  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
GPCRCO: GPCR / Class C : Orphans

IUPHAR Guide to PHARMACOLOGY protein family classification: GPRC5D
Class C Orphans

1 InterPro protein domain:
 IPR017978 GPCR_3_C

Graphical View of Domain Structure for InterPro Entry Q9NZD1

ProtoNet protein and cluster: Q9NZD1

UniProtKB/Swiss-Prot: GPC5D_HUMAN, Q9NZD1
Similarity: Belongs to the G-protein coupled receptor 3 family


GPRC5D for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
     
GPRC5D for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for GPRC5D:
 Increased 8N DNA content 

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
GPC5D_HUMAN, Q9NZD1: Cell membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane NAS11311935
GO:0016021integral component of membrane IEA--

GPRC5D for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for GPRC5D About                                                                                                See pathways by source

SuperPathContained pathways About
1GPCRs, Class C Metabotropic glutamate, pheromone
GPCRs, Class C Metabotropic glutamate, pheromone


1 BioSystems Pathway for GPRC5D
    GPCRs, Class C Metabotropic glutamate, pheromone


    Pathway & Disease-focused RT2 Profiler PCR Array including GPRC5D: 
          G Protein Coupled Receptors 384HT in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for GPRC5D

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

GPRC5D for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for GPRC5D (GPC5D)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for GPRC5D gene: 
NM_018654.1  

Unigene Cluster for GPRC5D:

G protein-coupled receptor, family C, group 5, member D
Hs.644599  [show with all ESTs]
Unigene Representative Sequence: BC069341
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000228887(uc010shp.2) ENST00000396333 ENST00000541128
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GenScript: all cDNA clones in your preferred vector: GPRC5D (NM_018654)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPRC5D
Primer
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  QuantiTect SYBR Green Assays in human, mouse, rat GPRC5D
  QuantiFast Probe-based Assays in human, mouse, rat GPRC5D

Additional mRNA sequence: 

AB099817.1 AF209923.1 BC069341.1 BC107077.1 BC107078.1 

3 DOTS entries:

DT.91712671  DT.99990800  DT.91887162 

11 AceView cDNA sequences:

NM_018654 BC069341 AF209923 BV187540 AB099817 BI039311 CD246158 BF175459 
BF371560 BF371549 BQ317906 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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GPRC5D expression in normal human tissues (normalized intensities)      GPRC5D embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGTTTTCCTG
GPRC5D Expression
About this image


GPRC5D expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Epithelial Cells
         Fetal Matrix Cells Hair Follicle
 
 Hair (Integumentary System)
         Fetal Matrix Cells Hair Follicle
GPRC5D Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

GPRC5D Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.644599

UniProtKB/Swiss-Prot: GPC5D_HUMAN, Q9NZD1
Tissue specificity: Widely expressed in the peripheral system. Expression pattern is high in pancreas, medium in
kidney, small intestine, spleen and testis, low in lung, colon, leukocyte, prostate and thymus and not detectable
in brain, heart, liver, placenta, skeletal muscle and ovary

    Pathway & Disease-focused RT2 Profiler PCR Array including GPRC5D: 
          G Protein Coupled Receptors 384HT in human mouse rat

Primer
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QuantiFast Probe-based Assays in human, mouse, rat GPRC5D
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPRC5D

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for GPRC5D gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Gprc5d1 , 5 G protein-coupled receptor, family C, group 5, member more1, 5 84.45(n)1
81.63(a)1
  6 (65.89 cM)5
937461  NM_001205396.11  NP_001192325.11 
 1351059915 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
47(a)
1 → many
1(48080775-48086278)
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
45(a)
38(a)
many ↔ many
many ↔ many
5(27524193-27540301)
5(27489654-27503740)
zebrafish
(Danio rerio)
Actinopterygii GPRC5A6
G protein-coupled receptor, family C, group 5, mem...
29(a)
1 → many
3(2111841-2114005) ENSDARG00000090051


ENSEMBL Gene Tree for GPRC5D (if available)
TreeFam Gene Tree for GPRC5D (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for GPRC5D gene
GPRC5A2  GPRC5B2  GPRC5C2  
3 SIMAP similar genes for GPRC5D using alignment to 2 protein entries:     GPC5D_HUMAN (see all proteins):
GPRC5A    GPRC5C    GPRC5B

GPRC5D for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for GPRC5D (see all 386)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1426276121,2
Cuntested113102545(+) GGGACG/AATGTA 2 /I syn11Minor allele frequency- A:0.00NA 4552
rs12913461,2
C,F,A,H--13093279(-) ctcaaC/Tcatgt 1 -- ds500124Minor allele frequency- T:0.45NS EA NA WA CSA 2345
rs1408900131,2
--13093288(+) AGATGA/GTGAAG 1 -- ds50010--------
rs1887968021,2
--13093305(+) TTCTGC/TGTTTT 1 -- ds50010--------
rs12913451,2
C,F,O,A,H--13093342(-) TGGGTT/CACATG 1 -- ds500130Minor allele frequency- C:0.45NS EA NA WA CSA 2911
rs1814826401,2
--13093348(+) ACCCAC/GTAGTA 1 -- ds50010--------
rs12913441,2
C,F,A,H--13093385(-) AGGGCA/TTTCTA 1 -- ds500130Minor allele frequency- T:0.16MN NS EA NA CSA WA 3303
rs1870763141,2
--13093495(+) AAAGAG/TACACA 1 -- ds50010--------
rs732885521,2
C,F--13093657(+) GGGCTG/ATGCTA 1 -- ds50011Minor allele frequency- A:0.50WA 2
rs745288391,2
C--13093670(+) CAGGAC/TGGTCT 1 -- ds50012Minor allele frequency- T:0.08CSA WA 120

HapMap Linkage Disequilibrium report for GPRC5D (13093709 - 13105081 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for GPRC5D:    About this table    
Variant IDTypeSubtypePubMed ID
esv2745567CNV Deletion23290073
nsv520173CNV Loss19592680
nsv832333CNV Gain17160897
nsv898814CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing GPRC5D
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607437    OMIM disorders: --

4 diseases for GPRC5D:    About MalaCards
hyperparathyroidism    multiple myeloma    myeloma    prostatitis


GPRC5D for disorders           About GeneDecksing

Genetic Association Database (GAD): GPRC5D
Human Genome Epidemiology (HuGE) Navigator: GPRC5D (1 document)

Export disorders for GPRC5D gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for GPRC5D gene integrated from 10 sources:
(articles sorted by number of sources associating them with GPRC5D)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. (PubMed id 11311935)1, 2, 9 Braeuner-Osborne H.... O'Hara P. (Biochim. Biophys. Acta 2001)
  2. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (FEBS Lett. 2002)
  5. Overexpression of G protein-coupled receptor 5D in the bone marrow is associated with poor prognosis in patients with multiple myeloma. (PubMed id 22591013)1 Atamaniuk J....Gaiger A. (Eur. J. Clin. Invest. 2012)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55507 HGNC: 13310 AceView: GPRC5D Ensembl:ENSG00000111291 euGenes: HUgn55507
ECgene: GPRC5D H-InvDB: GPRC5D

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for GPRC5D Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for GPRC5D gene:
Search GeneIP for patents involving GPRC5D

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 EMD Millipore genomic analysis products

  
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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