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Aliases for GPRC5D Gene

Aliases for GPRC5D Gene

  • G Protein-Coupled Receptor, Class C, Group 5, Member D 2 3
  • G Protein-Coupled Receptor, Family C, Group 5, Member D 2

External Ids for GPRC5D Gene

Summaries for GPRC5D Gene

Entrez Gene Summary for GPRC5D Gene

  • The protein encoded by this gene is a member of the G protein-coupled receptor family; however, the specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPRC5D Gene

GPRC5D (G Protein-Coupled Receptor, Class C, Group 5, Member D) is a Protein Coding gene. Among its related pathways are GPCRs, Class C Metabotropic glutamate, pheromone. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPRC5B.

Gene Wiki entry for GPRC5D Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPRC5D Gene

Genomics for GPRC5D Gene

Genomic Location for GPRC5D Gene

Start:
12,940,473 bp from pter
End:
12,953,894 bp from pter
Size:
13,422 bases
Orientation:
Minus strand

Genomic View for GPRC5D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPRC5D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPRC5D Gene

Regulatory Elements for GPRC5D Gene

Proteins for GPRC5D Gene

  • Protein details for GPRC5D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZD1-GPC5D_HUMAN
    Recommended name:
    G-protein coupled receptor family C group 5 member D
    Protein Accession:
    Q9NZD1
    Secondary Accessions:
    • Q3KNV3
    • Q7Z5J9
    • Q8TDS6

    Protein attributes for GPRC5D Gene

    Size:
    345 amino acids
    Molecular mass:
    38791 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPRC5D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPRC5D Gene

Proteomics data for GPRC5D Gene at MOPED

Post-translational modifications for GPRC5D Gene

No Post-translational modifications

Other Protein References for GPRC5D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPRC5D Gene

Domains for GPRC5D Gene

Gene Families for GPRC5D Gene

HGNC:
  • GPCRCO :GPCR / Class C : Orphans
IUPHAR :

Protein Domains for GPRC5D Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

GPC5D_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 3 family.:
    • Q9NZD1
genes like me logo Genes that share domains with GPRC5D: view

Function for GPRC5D Gene

Gene Ontology (GO) - Molecular Function for GPRC5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPRC5D: view

Phenotypes for GPRC5D Gene

GenomeRNAi human phenotypes for GPRC5D:
genes like me logo Genes that share phenotypes with GPRC5D: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GPRC5D Gene

Localization for GPRC5D Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPRC5D Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPRC5D Gene COMPARTMENTS Subcellular localization image for GPRC5D gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPRC5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane NAS 11311935
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPRC5D: view

Pathways for GPRC5D Gene

genes like me logo Genes that share pathways with GPRC5D: view

Pathways by source for GPRC5D Gene

1 BioSystems pathway for GPRC5D Gene

Interacting Proteins for GPRC5D Gene

Gene Ontology (GO) - Biological Process for GPRC5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPRC5D: view

Transcripts for GPRC5D Gene

mRNA/cDNA for GPRC5D Gene

(7) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPRC5D Gene

G protein-coupled receptor, family C, group 5, member D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPRC5D Gene

No ASD Table

Relevant External Links for GPRC5D Gene

GeneLoc Exon Structure for
GPRC5D
ECgene alternative splicing isoforms for
GPRC5D

Expression for GPRC5D Gene

mRNA expression in normal human tissues for GPRC5D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPRC5D Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (33.9) and Skin - Sun Exposed (Lower leg) (6.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for GPRC5D Gene

SOURCE GeneReport for Unigene cluster for GPRC5D Gene Hs.644599

mRNA Expression by UniProt/SwissProt for GPRC5D Gene

Q9NZD1-GPC5D_HUMAN
Tissue specificity: Widely expressed in the peripheral system. Expression pattern is high in pancreas, medium in kidney, small intestine, spleen and testis, low in lung, colon, leukocyte, prostate and thymus and not detectable in brain, heart, liver, placenta, skeletal muscle and ovary.
genes like me logo Genes that share expressions with GPRC5D: view

Orthologs for GPRC5D Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPRC5D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPRC5D 36
  • 99.13 (n)
  • 99.13 (a)
GPRC5D 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPRC5D 36
  • 85.46 (n)
  • 85.57 (a)
GPRC5D 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPRC5D 36
  • 88.21 (n)
  • 85.96 (a)
GPRC5D 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gprc5d 36
  • 84.45 (n)
  • 81.63 (a)
Gprc5d 16
Gprc5d 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPRC5D 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 44 (a)
OneToMany
-- 37
  • 56 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gprc5d 36
  • 83.53 (n)
  • 82.53 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 38 (a)
ManyToMany
-- 37
  • 45 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii GPRC5A 37
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 19 (a)
OneToMany
Species with no ortholog for GPRC5D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPRC5D Gene

ENSEMBL:
Gene Tree for GPRC5D (if available)
TreeFam:
Gene Tree for GPRC5D (if available)

Paralogs for GPRC5D Gene

Paralogs for GPRC5D Gene

Selected SIMAP similar genes for GPRC5D Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPRC5D: view

Variants for GPRC5D Gene

Sequence variations from dbSNP and Humsavar for GPRC5D Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs704226 -- 12,941,401(-) TTATT(A/G)TCCCC intron-variant
rs1291344 -- 12,940,451(-) AGGGC(A/T)TTCTA downstream-variant-500B
rs1291345 -- 12,940,408(-) TGGGT(C/T)ACATG downstream-variant-500B
rs1291346 -- 12,940,345(-) ctcaa(C/T)catgt downstream-variant-500B
rs1291370 -- 12,955,627(-) ggggt(A/G)tgaat upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPRC5D Gene

Variant ID Type Subtype PubMed ID
esv2745567 CNV Deletion 23290073
nsv832333 CNV Gain 17160897
nsv520173 CNV Loss 19592680
nsv898814 CNV Gain 21882294

Relevant External Links for GPRC5D Gene

HapMap Linkage Disequilibrium report
GPRC5D

Disorders for GPRC5D Gene

Relevant External Links for GPRC5D

Genetic Association Database (GAD)
GPRC5D
Human Genome Epidemiology (HuGE) Navigator
GPRC5D
genes like me logo Genes that share disorders with GPRC5D: view

No data available for UniProtKB/Swiss-Prot for GPRC5D Gene

Publications for GPRC5D Gene

  1. Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. (PMID: 11311935) Braeuner-Osborne H. … O'Hara P. (Biochim. Biophys. Acta 2001) 3 4 23
  2. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S. … Mitaku S. (FEBS Lett. 2002) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 3 49
  5. Overexpression of G protein-coupled receptor 5D in the bone marrow is associated with poor prognosis in patients with multiple myeloma. (PMID: 22591013) Atamaniuk J. … Gaiger A. (Eur. J. Clin. Invest. 2012) 3

Products for GPRC5D Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate GPRC5D
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for GPRC5D
    • Block miRNA regulation of GPRC5D using miScript Target Protectors
    • antibodies-online proteins for GPRC5D
    • antibodies-online antibodies for GPRC5D
    • antibodies-online kits for GPRC5D

    Sources for GPRC5D Gene

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