Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPRC5D Gene

Aliases for GPRC5D Gene

  • G Protein-Coupled Receptor Class C Group 5 Member D 2 3
  • G Protein-Coupled Receptor, Class C, Group 5, Member D 2 5
  • G Protein-Coupled Receptor, Family C, Group 5, Member D 2

External Ids for GPRC5D Gene

Previous GeneCards Identifiers for GPRC5D Gene

  • GC12M012824
  • GC12M013238
  • GC12M012993
  • GC12M012985
  • GC12M012986
  • GC12M012987
  • GC12M013093

Summaries for GPRC5D Gene

Entrez Gene Summary for GPRC5D Gene

  • The protein encoded by this gene is a member of the G protein-coupled receptor family; however, the specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPRC5D Gene

GPRC5D (G Protein-Coupled Receptor Class C Group 5 Member D) is a Protein Coding gene. Among its related pathways are GPCRs, Class C Metabotropic glutamate, pheromone. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPRC5B.

Gene Wiki entry for GPRC5D Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPRC5D Gene

Genomics for GPRC5D Gene

Regulatory Elements for GPRC5D Gene

Enhancers for GPRC5D Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPRC5D on UCSC Golden Path with GeneCards custom track

Genomic Location for GPRC5D Gene

12,940,554 bp from pter
12,979,517 bp from pter
38,964 bases
Minus strand

Genomic View for GPRC5D Gene

Genes around GPRC5D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPRC5D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPRC5D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPRC5D Gene

Proteins for GPRC5D Gene

  • Protein details for GPRC5D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor family C group 5 member D
    Protein Accession:
    Secondary Accessions:
    • Q3KNV3
    • Q7Z5J9
    • Q8TDS6

    Protein attributes for GPRC5D Gene

    345 amino acids
    Molecular mass:
    38791 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPRC5D Gene


neXtProt entry for GPRC5D Gene

Proteomics data for GPRC5D Gene at MOPED

Post-translational modifications for GPRC5D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPRC5D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPRC5D Gene

Domains & Families for GPRC5D Gene

Gene Families for GPRC5D Gene

Protein Domains for GPRC5D Gene


Suggested Antigen Peptide Sequences for GPRC5D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 3 family.
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GPRC5D: view

Function for GPRC5D Gene

genes like me logo Genes that share phenotypes with GPRC5D: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPRC5D

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPRC5D Gene

Localization for GPRC5D Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPRC5D Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPRC5D Gene COMPARTMENTS Subcellular localization image for GPRC5D gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPRC5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane NAS 11311935
genes like me logo Genes that share ontologies with GPRC5D: view

Pathways & Interactions for GPRC5D Gene

genes like me logo Genes that share pathways with GPRC5D: view

Pathways by source for GPRC5D Gene

1 BioSystems pathway for GPRC5D Gene

Interacting Proteins for GPRC5D Gene

Gene Ontology (GO) - Biological Process for GPRC5D Gene


No data available for SIGNOR curated interactions for GPRC5D Gene

Drugs & Compounds for GPRC5D Gene

No Compound Related Data Available

Transcripts for GPRC5D Gene

mRNA/cDNA for GPRC5D Gene

(7) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPRC5D Gene

G protein-coupled receptor, family C, group 5, member D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPRC5D Gene

No ASD Table

Relevant External Links for GPRC5D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPRC5D Gene

mRNA expression in normal human tissues for GPRC5D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPRC5D Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x33.9) and Skin - Sun Exposed (Lower leg) (x6.0).

Protein differential expression in normal tissues from HIPED for GPRC5D Gene

This gene is overexpressed in Hair follicle (45.2) and Serum (23.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPRC5D Gene

SOURCE GeneReport for Unigene cluster for GPRC5D Gene Hs.644599

mRNA Expression by UniProt/SwissProt for GPRC5D Gene

Tissue specificity: Widely expressed in the peripheral system. Expression pattern is high in pancreas, medium in kidney, small intestine, spleen and testis, low in lung, colon, leukocyte, prostate and thymus and not detectable in brain, heart, liver, placenta, skeletal muscle and ovary.
genes like me logo Genes that share expression patterns with GPRC5D: view

Protein tissue co-expression partners for GPRC5D Gene

Primer Products

Orthologs for GPRC5D Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPRC5D Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPRC5D 35
  • 85.46 (n)
  • 85.57 (a)
  • 85 (a)
(Canis familiaris)
Mammalia GPRC5D 35
  • 88.21 (n)
  • 85.96 (a)
  • 85 (a)
(Mus musculus)
Mammalia Gprc5d 35
  • 84.45 (n)
  • 81.63 (a)
Gprc5d 16
Gprc5d 36
  • 81 (a)
(Pan troglodytes)
Mammalia GPRC5D 35
  • 99.13 (n)
  • 99.13 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Gprc5d 35
  • 83.53 (n)
  • 82.53 (a)
(Monodelphis domestica)
Mammalia GPRC5D 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
-- 36
  • 56 (a)
(Gallus gallus)
Aves -- 36
  • 47 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
-- 36
  • 45 (a)
(Danio rerio)
Actinopterygii GPRC5A 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
Species with no ortholog for GPRC5D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPRC5D Gene

Gene Tree for GPRC5D (if available)
Gene Tree for GPRC5D (if available)

Paralogs for GPRC5D Gene

Paralogs for GPRC5D Gene

(3) SIMAP similar genes for GPRC5D Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPRC5D: view

Variants for GPRC5D Gene

Sequence variations from dbSNP and Humsavar for GPRC5D Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs3741822 - 12,950,332(-) TGACG(A/C)CGAGG reference, missense
rs2024516 -- 12,950,535(-) gccac(C/T)gcacc intron-variant, upstream-variant-2KB
rs7134402 -- 12,944,393(+) TGTAA(C/T)TTGAG intron-variant
rs7135352 -- 12,945,371(+) AGTCT(A/C)AAACA intron-variant
rs7138555 -- 12,945,330(+) GGTCT(C/T)AGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPRC5D Gene

Variant ID Type Subtype PubMed ID
esv2745567 CNV Deletion 23290073
nsv832333 CNV Gain 17160897
nsv520173 CNV Loss 19592680
nsv898814 CNV Gain 21882294

Variation tolerance for GPRC5D Gene

Residual Variation Intolerance Score: 39.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.25; 40.39% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPRC5D Gene

Disorders for GPRC5D Gene

Relevant External Links for GPRC5D

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPRC5D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPRC5D Gene

Publications for GPRC5D Gene

  1. Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. (PMID: 11311935) Braeuner-Osborne H. … O'Hara P. (Biochim. Biophys. Acta 2001) 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. GPRC5D is a promising marker for monitoring the tumor load and to target multiple myeloma cells. (PMID: 23510526) Cohen Y. … Kornberg A. (Hematology 2013) 3
  4. Overexpression of G protein-coupled receptor 5D in the bone marrow is associated with poor prognosis in patients with multiple myeloma. (PMID: 22591013) Atamaniuk J. … Gaiger A. (Eur. J. Clin. Invest. 2012) 3
  5. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 3

Products for GPRC5D Gene

Sources for GPRC5D Gene