Free for academic non-profit institutions. Other users need a Commercial license

GPRC5B Gene(Protein Coding)

G Protein-Coupled Receptor Class C Group 5 Member B

GCID:
GC16M019868
GIFtS:
54
Genes Participants
UDN Logo

Aliases for GPRC5B Gene

Aliases for GPRC5B Gene

  • G Protein-Coupled Receptor Class C Group 5 Member B 2 3
  • G Protein-Coupled Receptor, Class C, Group 5, Member B 2 3 5
  • G Protein-Coupled Receptor, Family C, Group 1, Member B 2 3
  • Retinoic Acid-Induced Gene 2 Protein 3 4
  • RAIG-2 3 4
  • RAIG2 3 4
  • G Protein-Coupled Receptor, Family C, Group 5, Member B 2
  • Retinoic Acid Responsive Gene Protein 3
  • A-69G12.1 4

External Ids for GPRC5B Gene

Previous GeneCards Identifiers for GPRC5B Gene

  • GC16M019362
  • GC16M019797
  • GC16M019836
  • GC16M019777
  • GC16M018406

Summaries for GPRC5B Gene

Entrez Gene Summary for GPRC5B Gene

  • This gene encodes a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The encoded protein may modulate insulin secretion and increased protein expression is associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for GPRC5B Gene

GPRC5B (G Protein-Coupled Receptor Class C Group 5 Member B) is a Protein Coding gene. Among its related pathways are GPCRs, Class C Metabotropic glutamate, pheromone. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled receptor binding. An important paralog of this gene is GPRC5A.

UniProtKB/Swiss-Prot for GPRC5B Gene

  • Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.

Gene Wiki entry for GPRC5B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPRC5B Gene

Genomics for GPRC5B Gene

Products:

  1. Regulatory Element

Regulatory Elements for GPRC5B Gene

Enhancers for GPRC5B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPRC5B on UCSC Golden Path with GeneCards custom track

Promoters for GPRC5B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPRC5B on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the GPRC5B gene promoter:

Genomic Location for GPRC5B Gene

Chromosome:
16
Start:
19,856,691 bp from pter
End:
19,886,167 bp from pter
Size:
29,477 bases
Orientation:
Minus strand

Genomic View for GPRC5B Gene

Genes around GPRC5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPRC5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPRC5B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GPRC5B Gene

Proteins for GPRC5B Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GPRC5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZH0-GPC5B_HUMAN
    Recommended name:
    G-protein coupled receptor family C group 5 member B
    Protein Accession:
    Q9NZH0
    Secondary Accessions:
    • D2DFB0
    • O75205
    • Q8NBZ8

    Protein attributes for GPRC5B Gene

    Size:
    403 amino acids
    Molecular mass:
    44795 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPRC5B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPRC5B Gene

Proteomics data for GPRC5B Gene at MOPED

Protein Expression for GPRC5B Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GPRC5B Gene

Other Protein References for GPRC5B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPRC5B Gene

Domains & Families for GPRC5B Gene

Gene Families for GPRC5B Gene

HGNC:
IUPHAR :

Protein Domains for GPRC5B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPRC5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZH0

UniProtKB/Swiss-Prot:

GPC5B_HUMAN :
  • Belongs to the G-protein coupled receptor 3 family.
Family:
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GPRC5B: view

Function for GPRC5B Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for GPRC5B Gene

UniProtKB/Swiss-Prot Function:
Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.
UniProtKB/Swiss-Prot Induction:
By all-trans retinoic acid (ATRA).

Gene Ontology (GO) - Molecular Function for GPRC5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding ISS --
genes like me logo Genes that share ontologies with GPRC5B: view

Phenotypes for GPRC5B Gene

MGI mutant phenotypes for GPRC5B:
inferred from 1 alleles
GenomeRNAi human phenotypes for GPRC5B:
genes like me logo Genes that share phenotypes with GPRC5B: view

Animal Models for GPRC5B Gene

MGI Knock Outs for GPRC5B:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPRC5B

miRNA for GPRC5B Gene

miRTarBase miRNAs that target GPRC5B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPRC5B Gene

Localization for GPRC5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPRC5B Gene

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localized in the plasma membrane and perinuclear vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPRC5B Gene COMPARTMENTS Subcellular localization image for GPRC5B gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPRC5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
GO:0045121 membrane raft IEA --
genes like me logo Genes that share ontologies with GPRC5B: view

Pathways & Interactions for GPRC5B Gene

genes like me logo Genes that share pathways with GPRC5B: view

Pathways by source for GPRC5B Gene

1 BioSystems pathway for GPRC5B Gene

Interacting Proteins for GPRC5B Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000300571%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000305372%0d%0a9606.ENSP00000325508%0d%0a
Selected Interacting proteins: ENSP00000300571 for GPRC5B Gene via STRING

Gene Ontology (GO) - Biological Process for GPRC5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0010976 positive regulation of neuron projection development IEA --
GO:0045860 positive regulation of protein kinase activity IEA --
GO:0060907 positive regulation of macrophage cytokine production ISS --
GO:0061098 positive regulation of protein tyrosine kinase activity ISS --
genes like me logo Genes that share ontologies with GPRC5B: view

No data available for SIGNOR curated interactions for GPRC5B Gene

Drugs & Compounds for GPRC5B Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for GPRC5B Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for GPRC5B Gene

(4) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(346) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPRC5B Gene

G protein-coupled receptor, family C, group 5, member B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPRC5B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - - -
SP2: - - - - -
SP3: - - -
SP4: -
SP5:

Relevant External Links for GPRC5B Gene

GeneLoc Exon Structure for
GPRC5B
ECgene alternative splicing isoforms for
GPRC5B

Expression for GPRC5B Gene

Products:

  1. Primer

mRNA expression in normal human tissues for GPRC5B Gene

mRNA expression in normal human tissues for GPRC5B Gene
mRNA expression by BioGPS for GPRC5B GenemRNA expression by GTEx for GPRC5B Gene

mRNA differential expression in normal tissues according to GTEx for GPRC5B Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.3), Brain - Substantia nigra (x4.3), and Brain - Caudate (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for GPRC5B Gene

This gene is overexpressed in Urine (59.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPRC5B Gene



SOURCE GeneReport for Unigene cluster for GPRC5B Gene Hs.148685

mRNA Expression by UniProt/SwissProt for GPRC5B Gene

Q9NZH0-GPC5B_HUMAN
Tissue specificity: Expression is high in kidney, pancreas, and testis, medium in brain, heart, prostate, small intestine, and spleen, low in liver, placenta, skeletal muscle, colon, ovary, and thymus, and not detectable in lung and peripheral leukocyte. According to PubMed:10945465, highly expressed in most brain areas examined, with the highest levels observed in corpus callosum, caudate nucleus, putamen, substantia nigra, thalamus, hippocampus, and spinal chord as well as in dorsal root ganglia (DRG). In the periphery, expression levels are relatively low, compared to the CNS, with the strongest expression detected in pancreas, testis, uterus, and stomach.
genes like me logo Genes that share expression patterns with GPRC5B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for GPRC5B Gene

Orthologs for GPRC5B Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPRC5B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia GPRC5B 35
  • 89.92 (n)
  • 90.18 (a)
GPRC5B 36
  • 90 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia GPRC5B 35
  • 89.75 (n)
  • 91.47 (a)
GPRC5B 36
  • 91 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Gprc5b 35
  • 86.32 (n)
  • 87.56 (a)
Gprc5b 16
Gprc5b 36
  • 85 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia GPRC5B 35
  • 99.34 (n)
  • 99.75 (a)
GPRC5B 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Gprc5b 35
  • 85.54 (n)
  • 87.27 (a)
oppossum
(Monodelphis domestica)
 Mammalia GPRC5B 36
  • 84 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves GPRC5B 35
  • 72.57 (n)
  • 80 (a)
GPRC5B 36
  • 80 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia GPRC5B 36
  • 76 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia gprc5b 35
  • 70.11 (n)
  • 78.04 (a)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.3029 35
zebrafish
(Danio rerio)
 Actinopterygii LOC570207 35
  • 58.48 (n)
  • 48.85 (a)
gprc5ba 36
  • 47 (a)
 OneToMany
gprc5bb 36
  • 43 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 31 (a)
 OneToMany
Species with no ortholog for GPRC5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPRC5B Gene

ENSEMBL:
Gene Tree for GPRC5B (if available)
TreeFam:
Gene Tree for GPRC5B (if available)

Paralogs for GPRC5B Gene

Paralogs for GPRC5B Gene

(3) SIMAP similar genes for GPRC5B Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with GPRC5B: view

Variants for GPRC5B Gene

Sequence variations from dbSNP and Humsavar for GPRC5B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs170575 -- 19,868,204(+) acccc(A/G)tctct intron-variant
rs172907 -- 19,871,760(+) AGAGT(A/G)TCTTT intron-variant
rs183452 -- 19,870,678(+) GGTTG(A/C)AGACT intron-variant
rs227758 -- 19,869,785(+) AACAC(C/T)GGGGg intron-variant
rs227759 -- 19,865,959(+) gagtc(C/T)cactc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPRC5B Gene

Variant ID Type Subtype PubMed ID
nsv436835 CNV Insertion 17901297
nsv428321 CNV Loss 18775914
nsv103121 CNV Loss 16902084

Variation tolerance for GPRC5B Gene

Residual Variation Intolerance Score: 44.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPRC5B Gene

Disorders for GPRC5B Gene

Relevant External Links for GPRC5B

Genetic Association Database (GAD)
GPRC5B
Human Genome Epidemiology (HuGE) Navigator
GPRC5B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPRC5B

No disorders were found for GPRC5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPRC5B Gene

Publications for GPRC5B Gene

  1. Sequence and expression pattern of a novel human orphan G-protein- coupled receptor, GPRC5B, a family C receptor with a short amino- terminal domain. (PMID: 10783259) Braeuner-Osborne H. … Krogsgaard-Larsen P. (Genomics 2000) 2 3 4 23 67
  2. Molecular cloning and characterization of two novel retinoic acid- inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). (PMID: 10945465) Robbins M.J. … Pangalos M.N. (Genomics 2000) 3 23
  3. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Intercellular transfer of GPRC5B via exosomes drives HGF-mediated outward growth. (PMID: 24412205) Kwon S.H. … Mostov K.E. (Curr. Biol. 2014) 3

Products for GPRC5B Gene

Sources for GPRC5B Gene

Content