Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPRC5A Gene

Aliases for GPRC5A Gene

  • G Protein-Coupled Receptor Class C Group 5 Member A 2 3
  • G Protein-Coupled Receptor, Class C, Group 5, Member A 2 3 5
  • G-Protein Coupled Receptor Family C Group 5 Member A 3 4
  • Retinoic Acid-Induced Gene 1 Protein 3 4
  • Phorbol Ester Induced Gene 1 3 4
  • Retinoic Acid Induced 3 2 3
  • GPCR5A 3 4
  • PEIG-1 3 4
  • RAIG1 3 4
  • RAI3 3 4
  • G Protein-Coupled Receptor, Family C, Group 5, Member A 3
  • Orphan G-Protein-Coupling Receptor PEIG-1 3
  • Phorbol Ester Induced Protein-1 3
  • Retinoic Acid Responsive 3
  • TPA Induced Gene 1 3
  • RAIG-1 4
  • TIG1 3

External Ids for GPRC5A Gene

Previous HGNC Symbols for GPRC5A Gene

  • RAI3

Previous GeneCards Identifiers for GPRC5A Gene

  • GC12P012937
  • GC12P013047
  • GC12P012813

Summaries for GPRC5A Gene

Entrez Gene Summary for GPRC5A Gene

  • This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPRC5A Gene

GPRC5A (G Protein-Coupled Receptor Class C Group 5 Member A) is a Protein Coding gene. Among its related pathways are Integrated Pancreatic Cancer Pathway and GPCRs, Class C Metabotropic glutamate, pheromone. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPRC5B.

UniProtKB/Swiss-Prot for GPRC5A Gene

  • Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218).

Gene Wiki entry for GPRC5A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPRC5A Gene

Genomics for GPRC5A Gene

Regulatory Elements for GPRC5A Gene

Promoters for GPRC5A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPRC5A on UCSC Golden Path with GeneCards custom track

Genomic Location for GPRC5A Gene

Chromosome:
12
Start:
12,890,782 bp from pter
End:
12,917,937 bp from pter
Size:
27,156 bases
Orientation:
Plus strand

Genomic View for GPRC5A Gene

Genes around GPRC5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPRC5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPRC5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPRC5A Gene

Proteins for GPRC5A Gene

  • Protein details for GPRC5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFJ5-RAI3_HUMAN
    Recommended name:
    Retinoic acid-induced protein 3
    Protein Accession:
    Q8NFJ5
    Secondary Accessions:
    • B3KV45
    • O95357

    Protein attributes for GPRC5A Gene

    Size:
    357 amino acids
    Molecular mass:
    40251 Da
    Quaternary structure:
    • Interacts (via its transmembrane domain) with EGFR.

neXtProt entry for GPRC5A Gene

Proteomics data for GPRC5A Gene at MOPED

Post-translational modifications for GPRC5A Gene

  • Phosphorylated in two conserved double-tyrosine motifs, TYR-317/TYR-320 and TYR-347/TYR-350, by EGFR; leading to inactivation of the tumor suppressive function of GPRC5A in lung cancer cells. TYR-317 and TYR-320 are the preferred residues responsible for EGFR-mediated GPRC5A phosphorylation.
  • Ubiquitination at Lys 348 and Lys 353
  • Glycosylation at Asn 158
  • Modification sites at PhosphoSitePlus

Other Protein References for GPRC5A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GPRC5A (RAIG1)

No data available for DME Specific Peptides for GPRC5A Gene

Domains & Families for GPRC5A Gene

Gene Families for GPRC5A Gene

Protein Domains for GPRC5A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPRC5A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NFJ5

UniProtKB/Swiss-Prot:

RAI3_HUMAN :
  • Belongs to the G-protein coupled receptor 3 family.
Family:
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GPRC5A: view

Function for GPRC5A Gene

Molecular function for GPRC5A Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218).
UniProtKB/Swiss-Prot Induction:
By all-trans retinoic acid (ATRA).

Gene Ontology (GO) - Molecular Function for GPRC5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25311788
genes like me logo Genes that share ontologies with GPRC5A: view
genes like me logo Genes that share phenotypes with GPRC5A: view

Animal Models for GPRC5A Gene

MGI Knock Outs for GPRC5A:

Animal Model Products

CRISPR Products

miRNA for GPRC5A Gene

miRTarBase miRNAs that target GPRC5A

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPRC5A Gene

Localization for GPRC5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPRC5A Gene

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localized in perinuclear vesicles, probably Golgi-associated vesicles. {ECO:0000269 PubMed:18000218}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPRC5A Gene COMPARTMENTS Subcellular localization image for GPRC5A gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPRC5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 18000218
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GPRC5A: view

Pathways & Interactions for GPRC5A Gene

genes like me logo Genes that share pathways with GPRC5A: view

Pathways by source for GPRC5A Gene

Interacting Proteins for GPRC5A Gene

Gene Ontology (GO) - Biological Process for GPRC5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity ISS --
genes like me logo Genes that share ontologies with GPRC5A: view

No data available for SIGNOR curated interactions for GPRC5A Gene

Drugs & Compounds for GPRC5A Gene

(1) Drugs for GPRC5A Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tretinoin Approved, Investigational Nutra Full agonist, Agonist, Target 210

(1) Additional Compounds for GPRC5A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GPRC5A: view

Transcripts for GPRC5A Gene

Unigene Clusters for GPRC5A Gene

G protein-coupled receptor, family C, group 5, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPRC5A Gene

No ASD Table

Relevant External Links for GPRC5A Gene

GeneLoc Exon Structure for
GPRC5A
ECgene alternative splicing isoforms for
GPRC5A

Expression for GPRC5A Gene

mRNA expression in normal human tissues for GPRC5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPRC5A Gene

This gene is overexpressed in Lung (x12.9).

Protein differential expression in normal tissues from HIPED for GPRC5A Gene

This gene is overexpressed in Urine (29.5), Lung (20.8), Amniocyte (7.7), and Cervix (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPRC5A Gene



SOURCE GeneReport for Unigene cluster for GPRC5A Gene Hs.631733

mRNA Expression by UniProt/SwissProt for GPRC5A Gene

Q8NFJ5-RAI3_HUMAN
Tissue specificity: Expressed at high level in fetal and adult lung tissues but repressed in most human lung cancers (PubMed:9857033, PubMed:18000218). Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to moderate levels. Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes. According to PubMed:10783259, expressed at low but detectable level in pancreas and heart.
genes like me logo Genes that share expression patterns with GPRC5A: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for GPRC5A Gene

Orthologs for GPRC5A Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPRC5A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPRC5A 35
  • 80.3 (n)
  • 76.47 (a)
GPRC5A 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPRC5A 35
  • 82.63 (n)
  • 77.59 (a)
GPRC5A 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gprc5a 35
  • 79.27 (n)
  • 76.79 (a)
Gprc5a 16
Gprc5a 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPRC5A 35
  • 99.16 (n)
  • 98.6 (a)
GPRC5A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gprc5a 35
  • 79.43 (n)
  • 75.71 (a)
oppossum
(Monodelphis domestica)
Mammalia GPRC5A 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPRC5A 35
  • 61.33 (n)
  • 54.29 (a)
-- 36
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 41 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gprc5a 35
  • 55.98 (n)
  • 48.4 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68729 35
zebrafish
(Danio rerio)
Actinopterygii GPRC5A 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToMany
Species with no ortholog for GPRC5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPRC5A Gene

ENSEMBL:
Gene Tree for GPRC5A (if available)
TreeFam:
Gene Tree for GPRC5A (if available)

Paralogs for GPRC5A Gene

Paralogs for GPRC5A Gene

(3) SIMAP similar genes for GPRC5A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GPRC5A: view

Variants for GPRC5A Gene

Sequence variations from dbSNP and Humsavar for GPRC5A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs850932 - 12,908,601(-) CAGAC(C/T)GACAG reference, missense
rs11550683 - 12,908,275(+) TGGTT(G/T)CCGCA reference, missense
rs12368599 - 12,908,793(+) TGCTC(A/G)CCTAC reference, missense
rs850933 -- 12,906,986(+) gaggc(A/G)gaggt intron-variant
rs850934 -- 12,906,847(+) GAGGT(C/T)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPRC5A Gene

Variant ID Type Subtype PubMed ID
esv2745567 CNV Deletion 23290073
nsv832333 CNV Gain 17160897

Variation tolerance for GPRC5A Gene

Residual Variation Intolerance Score: 82.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.34; 63.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPRC5A Gene

HapMap Linkage Disequilibrium report
GPRC5A
Human Gene Mutation Database (HGMD)
GPRC5A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPRC5A Gene

Disorders for GPRC5A Gene

Relevant External Links for GPRC5A

Genetic Association Database (GAD)
GPRC5A
Human Genome Epidemiology (HuGE) Navigator
GPRC5A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPRC5A

No disorders were found for GPRC5A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPRC5A Gene

Publications for GPRC5A Gene

  1. Molecular cloning and characterization of a novel retinoic acid- inducible gene that encodes a putative G protein-coupled receptor. (PMID: 9857033) Cheng Y. … Lotan R. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. Identification of the retinoic acid-inducible Gprc5a as a new lung tumor suppressor gene. (PMID: 18000218) Tao Q. … Lotan R. (J. Natl. Cancer Inst. 2007) 3 23
  3. Sequence and expression pattern of a novel human orphan G-protein- coupled receptor, GPRC5B, a family C receptor with a short amino- terminal domain. (PMID: 10783259) Braeuner-Osborne H. … Krogsgaard-Larsen P. (Genomics 2000) 3 23
  4. Molecular cloning and characterization of two novel retinoic acid- inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). (PMID: 10945465) Robbins M.J. … Pangalos M.N. (Genomics 2000) 3 23
  5. Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells. (PMID: 8832110) Cafferata E.G. … Santa-Coloma T.A. (Cell. Mol. Biol. (Noisy-le-grand) 1996) 2 3

Products for GPRC5A Gene

Sources for GPRC5A Gene

Back to Top

Content